CD49d Antibody [R1-2] Cat. No.: 76-809
CD49d Antibody [R1-2]
Specifications
HOST SPECIES: Rat
SPECIES REACTIVITY: Mouse
TESTED APPLICATIONS: Flow, Func
The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), SPECIFICITY: which forms the VLA-4 complex with CD29 (integrin beta 1).
Properties
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin PURIFICATION: level is determined by LAL test to be less than 0.01 EU/µg of the protein.
CLONALITY: Monoclonal
ISOTYPE: Rat IgG2b, kappa
CONJUGATE: Unconjugated
PHYSICAL STATE: liquid
BUFFER: Phosphate-buffered aqueous solution, ph7.2.
CONCENTRATION: batch dependent
STORAGE CONDITIONS: The product should be stored undiluted at 4˚C . Do not freeze.
September 27, 2021 1 https://www.prosci-inc.com/cd49d-antibody-r1-2-76-809.html Additional Info
OFFICIAL SYMBOL: Itga4
ALTERNATE NAMES: CD49D, Itga4B, Itga4
GENE ID: 16401
USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background and References
The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), which forms the VLA-4 complex with CD29 (integrin beta 1). VLA-4 is expressed on BACKGROUND: thymocytes, monocytes, and a subset of peripheral lymphocytes. It is the receptor for fibronectin and CD106 (VCAM-1). CD49d also forms a receptor for mucosal vascular addressin (MAdCAM-1) with integrin beta 7.
1) Deckert, M., Kubar, J., Zoccola, D., Bernard‐Pomier, G., Angelisova, P., Horejsi, V., REFERENCES: Bernard, A. (1992). CD59 molecule: a second ligand for CD2 in T cell adhesion.European journal of immunology,22(11), 2943-2947.
2) Korty, P. E., Brando, C. L. A. R. A., Shevach, E. M. (1991). CD59 functions as a signal- transducing molecule for human T cell activation.The Journal of immunology,146(12), 4092-4098.
3) Davies, A., Simmons, D. L., Hale, G., Harrison, R. A., Tighe, H., Lachmann, P. J., Waldmann, H. (1989). CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.The Journal of experimental medicine,170(3), 637-654.
ANTIBODIES FOR RESEARCH USE ONLY.
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