CD49d Antibody [R1-2] Cat. No.: 76-809

CD49d Antibody [R1-2]

Specifications

HOST SPECIES: Rat

SPECIES REACTIVITY: Mouse

TESTED APPLICATIONS: Flow, Func

The R1-2 monoclonal antibody specifically reacts with mouse CD49d ( alpha 4), SPECIFICITY: which forms the VLA-4 complex with CD29 ().

Properties

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin PURIFICATION: level is determined by LAL test to be less than 0.01 EU/µg of the .

CLONALITY: Monoclonal

ISOTYPE: Rat IgG2b, kappa

CONJUGATE: Unconjugated

PHYSICAL STATE: liquid

BUFFER: Phosphate-buffered aqueous solution, ph7.2.

CONCENTRATION: batch dependent

STORAGE CONDITIONS: The product should be stored undiluted at 4˚C . Do not freeze.

September 27, 2021 1 https://www.prosci-inc.com/cd49d-antibody-r1-2-76-809.html Additional Info

OFFICIAL SYMBOL: Itga4

ALTERNATE NAMES: CD49D, Itga4B, Itga4

GENE ID: 16401

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

The R1-2 monoclonal antibody specifically reacts with mouse CD49d (), which forms the VLA-4 complex with CD29 (integrin beta 1). VLA-4 is expressed on BACKGROUND: thymocytes, monocytes, and a subset of peripheral lymphocytes. It is the for fibronectin and CD106 (VCAM-1). CD49d also forms a receptor for mucosal vascular (MAdCAM-1) with .

1) Deckert, M., Kubar, J., Zoccola, D., Bernard‐Pomier, G., Angelisova, P., Horejsi, V., REFERENCES: Bernard, A. (1992). CD59 molecule: a second for CD2 in T cell adhesion.European journal of immunology,22(11), 2943-2947.

2) Korty, P. E., Brando, C. L. A. R. A., Shevach, E. M. (1991). CD59 functions as a signal- transducing molecule for human T cell activation.The Journal of immunology,146(12), 4092-4098.

3) Davies, A., Simmons, D. L., Hale, G., Harrison, R. A., Tighe, H., Lachmann, P. J., Waldmann, H. (1989). CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.The Journal of experimental medicine,170(3), 637-654.

ANTIBODIES FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.

September 27, 2021 2 https://www.prosci-inc.com/cd49d-antibody-r1-2-76-809.html