CD49d Antibody [R1-2] Cat. No.: 76-809 CD49d Antibody [R1-2] Specifications HOST SPECIES: Rat SPECIES REACTIVITY: Mouse TESTED APPLICATIONS: Flow, Func The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), SPECIFICITY: which forms the VLA-4 complex with CD29 (integrin beta 1). Properties The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin PURIFICATION: level is determined by LAL test to be less than 0.01 EU/µg of the protein. CLONALITY: Monoclonal ISOTYPE: Rat IgG2b, kappa CONJUGATE: Unconjugated PHYSICAL STATE: liquid BUFFER: Phosphate-buffered aqueous solution, ph7.2. CONCENTRATION: batch dependent STORAGE CONDITIONS: The product should be stored undiluted at 4˚C . Do not freeze. September 27, 2021 1 https://www.prosci-inc.com/cd49d-antibody-r1-2-76-809.html Additional Info OFFICIAL SYMBOL: Itga4 ALTERNATE NAMES: CD49D, Itga4B, Itga4 GENE ID: 16401 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), which forms the VLA-4 complex with CD29 (integrin beta 1). VLA-4 is expressed on BACKGROUND: thymocytes, monocytes, and a subset of peripheral lymphocytes. It is the receptor for fibronectin and CD106 (VCAM-1). CD49d also forms a receptor for mucosal vascular addressin (MAdCAM-1) with integrin beta 7. 1) Deckert, M., Kubar, J., Zoccola, D., Bernard‐Pomier, G., Angelisova, P., Horejsi, V., REFERENCES: Bernard, A. (1992). CD59 molecule: a second ligand for CD2 in T cell adhesion.European journal of immunology,22(11), 2943-2947. 2) Korty, P. E., Brando, C. L. A. R. A., Shevach, E. M. (1991). CD59 functions as a signal- transducing molecule for human T cell activation.The Journal of immunology,146(12), 4092-4098. 3) Davies, A., Simmons, D. L., Hale, G., Harrison, R. A., Tighe, H., Lachmann, P. J., Waldmann, H. (1989). CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.The Journal of experimental medicine,170(3), 637-654. ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 27, 2021 2 https://www.prosci-inc.com/cd49d-antibody-r1-2-76-809.html.