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Cancer Metabolism: Molecular Targeting and Implications for Therapy CANCER METABOLISM: MOLECULAR TARGETING AND IMPLICATIONS FOR THERAPY EDITED BY : Shanmugasundaram Ganapathy-Kanniappan PUBLISHED IN : Frontiers in Oncology and Frontiers in Pharmacology Frontiers Copyright Statement About Frontiers © Copyright 2007-2017 Frontiers Media SA. All rights reserved. Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering All content included on this site, approach to the world of academia, radically improving the way scholarly research such as text, graphics, logos, button icons, images, video/audio clips, is managed. The grand vision of Frontiers is a world where all people have an equal downloads, data compilations and software, is the property of or is opportunity to seek, share and generate knowledge. 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All copyright, and all rights therein, Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: are protected by national and international copyright laws. they are collections of at least ten articles, all centered on a particular subject. With their The above represents a summary unique mix of varied contributions from Original Research to Review Articles, Frontiers only. For the full conditions see the Research Topics unify the most influential researchers, the latest key findings and historical Conditions for Authors and the Conditions for Website Use. advances in a hot research area! Find out more on how to host your own Frontiers ISSN 1664-8714 Research Topic or contribute to one as an author by contacting the Frontiers Editorial ISBN 978-2-88945-322-1 DOI 10.3389/978-2-88945-322-1 Office:[email protected] Frontiers in Oncology and Frontiers in Pharmacology 1 October 2017 | Cancer Metabolism CANCER METABOLISM: MOLECULAR TARGETING AND IMPLICATIONS FOR THERAPY Topic Editor: Shanmugasundaram Ganapathy-Kanniappan, Johns Hopkins University School of Medicine, United States Development of an effective anticancer therapeutic necessitates the selection of cancer-related or cancer-specific pathways or molecules that are sensitive to intervention. Several such critical yet sensitive molecular targets have been recognized, and their specific antagonists or inhibitors validated as potential therapeutics in preclinical models. Yet, majority of anticancer principles or therapeutics show limited success in the clinical translation. Thus, the need for the development of an effective therapeutic strategy persists. “Altered energy metabolism” in cancer is one of the earliest known biochemical phenotypes which dates back to the early 20th century. Illustration of the cooperativity between The German scientist, Otto Warburg and oncogenic events (blue wheel) and metabolic his team (Warburg, Wind, Negelein 1926; reprogramming (green wheel) in cancer Warburg, Wind, Negelein 1927) provided the progression (brown wheel). first evidence that the glucose metabolism Cover image by Shanmugasundaram of cancer cells diverge from normal cells. Ganapathy-Kanniappan This phenomenal discovery on deregulated glucose metabolism or cellular bioenergetics is frequently witnessed in majority of solid malignancies. Currently, the altered glucose metabolism is used in the clinical diagnosis of cancer through positron emission tomography (PET) imaging. Thus, the “deregulated bioenergetics” is a clinically relevant metabolic signature of cancer cells, hence recognized as one of the hallmarks of cancer (Hanahan and Weinberg 2011). Accumulating data unequivocally demonstrate that, besides cellular bioenergetics, cancer metabolism facilitates several cancer-related processes including metastasis, therapeutic Frontiers in Oncology and Frontiers in Pharmacology 2 October 2017 | Cancer Metabolism resistance and so on. Recent reports also demonstrate the oncogenic regulation of glucose metabolism (e.g. glycolysis) indicating a functional link between neoplastic growth and cancer metabolism. Thus, cancer metabolism, which is already exploited in cancer diagnosis, remains an attractive target for therapeutic intervention as well. The Frontiers in Oncology Research Topic “Cancer Metabolism: Molecular Targeting and Implications for Therapy” emphases on recent advances in our understanding of metabolic reprogramming in cancer, and the recognition of key molecules for therapeutic targeting. Besides, the topic also deliberates the implications of metabolic targeting beyond the energy metabolism of cancer. The research topic integrates a series of reviews, mini-reviews and original research articles to share current perspectives on cancer metabolism, and to stimulate an open forum to discuss potential challenges and future directions of research necessary to develop effective anticancer strategies. Acknowledgment I sincerely thank the Frontiers for providing the opportunity and constant support throughout the process of this research topic and eBook production. I gratefully acknowledge all the authors for their valuable contributions. Finally, I would like to thank my brother, Saravana Kumar, G.K., whose personal sacrifices and unflinching encouragement made my career in science possible. References Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: The next generation. Cell. 144(5):646-74. Warburg O, Wind F, Negelein E. 1926. Über den stoffwechsel der tumoren in körper. Klinische Wochenschrift. 5:829-32. Warburg O, Wind F, Negelein E. 1927. The metabolism of tumors in the body. J Gen Physiol. 8(6):519-30. Citation: Ganapathy-Kanniappan, S., ed. (2017). Cancer Metabolism: Molecular Targeting and Implications for Therapy. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-322-1 Frontiers in Oncology and Frontiers in Pharmacology 3 October 2017 | Cancer Metabolism Table of Contents 05 Editorial: Cancer Metabolism: Molecular Targeting and Implications for Therapy Shanmugasundaram Ganapathy-Kanniappan 07 Time and Circumstances: Cancer Cell Metabolism at Various Stages of Disease Progression Georg F. Weber 16 The Metabolic Phenotype of Prostate Cancer Eric Eidelman, Jeffrey Twum-Ampofo, Jamal Ansari and Mohummad Minhaj Siddiqui 22 Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming Jeffrey A. Nickerson, Qiong Wu and Anthony N. Imbalzano 31 Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy Seema Gupta, Amrita Roy and Bilikere S. Dwarakanath 55 Taming Tumor Glycolysis and Potential Implications for Immunotherapy Shanmugasundaram Ganapathy-Kanniappan 62 Aldo–Keto Reductase AKR1C1–AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy Chen-Ming Zeng, Lin-Lin Chang, Mei-Dan Ying, Ji Cao, Qiao-Jun He, Hong Zhu and Bo Yang 71 Prostate Cancer and Aspirin Use: Synopsis of the Proposed Molecular Mechanisms Nadeem Bilani, Hisham Bahmad
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