1. Indicate the mechanism of broncholytic action of Ipratropii D. Glaucinum. bromidum: E. Falimint. A. Myotropic influence. B. Blockade of M-cholinoceptors. 9. Indicate the oppressing a peripheral link of cough C. Stimulation of -receptors. reflex: D. Inhibition of phosphodiasterase. A. Atropini sulfas. E. Activation of adenilatcyclase. B. Codeini phosphas. C. Ethylmorphini hydrochloridum. 2. Indicate the mechanism of bronchodilator – Salbutamolum D. Bromhexinum. action: E. Libexinum.

A. Stimulation of 2-receptors. B. Stimulation of -receptors. 10. The mechanism of expectorant action of Thermopsis herb infusion is: C. Inhibition of 2-receptors. D. Inhibition of phosphodiasterase. A. Irritates bronchial glands during excretion that leads to E. Blockade of adenosine receptors. stimulation of their secretion. B. Directly stimulates peristalsis of bronchial smooth 3. Indicate the of with effect and muscles. anti-inflammatory properties: C. It destroys proteins of sputum. A. Bemegridum. D. It stimulates bronchial secretion reflexively irritating B. Aethimizolum. the stomach receptors. C. Coffeinum-natrii benzoas. E. It inhibits the cough center. D. Cordiaminum. E. Lobelini hydrochloridum. 11. Indicate an expectorant agent possessing the reflex type of action: 4. Indicate the antitussive agent with central non-narcotic type A. Bromhexinum. of action: B. Infusum herbae Thermopsidis. A. Codeini phosphas. C. Acetylcysteinum. B. Aethylmorphini hydrochloridum. D. Trypsinum. C. Libexinum. E. Kalii iodidum. D. Oxeladini citras. E. Bromhexinum. 12. Mark the group of used for elimination of bronchial attacks. 5. Indicate the antitussive agent of peripheral action: A. M-cholinomimetics. A. Codeini phosphas. B. N-cholinomimetics. B. Aethylmorphini hydrochloridum. C. Sympatholytics. C. Libexinum. D. Beta-adrenoblockers. D. Glaucini hydrochloridum. E. Beta-adrenomimetics. E. Bromhexinum. 13. Indicate the mechanism of broncholytic effect of 6. A child was born with asphyxia. What agent is it necessary : to introduce for stimulation of breath? A. Blockade of -2-adrenoreceptors. A. Lidocainum. B. Stimulation of -1-adrenoreceptors. B. Lobelini hydrochloridum. C. Stimulation -2-adrenoreceptors. C. Prazosinum. D. Stimulation of -1 and -2-adrenoreceptors. D. Atropini sulfas. E. Blockade of N-cholinoreceptors. E. Proserinum. 14. Activation of what receptor formations should be produced 7. To specify an which possesses sedative activity at the patient with bronchial asthma to eliminate ? and can be used as desensibilizing agent in bronchial A. -adrenoreceptors asthma: B. -adrenoreceptors and -adrenoreceptors A. Carbogenum. C. M-cholinoreceptors B. Camphora. D. N-cholinoreceptors C. Cordiaminum. E. -adrenoreceptors D. Aethimizolum. E. Dimedrolum. 15. What from the listed below effects of explains their effectiveness in the case of pulmonary edema? 8. Indicate antitussive agent possessing properties of opioid A. Reduce the pressure in the systemic circulation. : B. Reduce the excitability of . A. Codeini phosphas. C. Increase osmotic pressure of the blood. B. Libexinum. D. Cause the blood redistribution in the organism. C. Tussuprex. E. Improve systemic hemodynamix. 1 16. Indicate the agent which should be used to treat A. Propranololum. pulmonary edema: B. Anaesthesinum. A. Spironolactonum. C. Verapamilum. B. Hydrochlorthiazidum (dichlothiazidum). D. Pananginum. C. Triamterenum. E. Lidocainum. D. Furosemidum. E. Acetazolamidum (diacarbum). 23. A patient complains of edemas, rapid pulse, short breath, cyanosis of mucous tunics. The diagnosis is chronic cardiac 17. Benzohexonium was introduced to a patient with insufficiency. What is it necessary to prescribe to the pulmonary edema caused by systemic arterial hypertension. patient? Indicate the mechanism of action of this agent? A. Mesatonum. A. Activation of -adrenoreceptors of vessels. B. Papaverini hydrochloridum. B. Blockade of dopamine receptors in the CNS. C. Digoxinum. C. Stimulation of M-cholinoreceptors. D. Cordiaminum. D. Activation of adrenoreceptors of vasomotor center. E. Nitroglycerinum. E. Blockade of N-cholinoreceptors of vegetative ganglions. 24. A patient with signs of acute cardiac insufficiency is delivered to a hospital. Which drug is it necessary to 18. A patient with bronchial asthma attack has a concomitant prescribe urgently? disease – angina pectoris. What bronchodilator is to be A. Corglyconum. prescribed in this case? B. Aethimizolum. A. Salbutamolum. C. Dithylinum. B. Adrenalini hydrochloridum. D. Piridostigmini bromidum. C. Isadrinum. E. Digitoxinum. D. Aminophyllinum. E. Atropini sulfas. 25. A patient with myocardial infarction and cardiac insufficiency has ventricular arrhythmia. What 19. A 42-year-old patient has bronchial asthma. To relieve antiarrhythmic drug is a medicine of choice in this case? the attacks of bronchospasm a doctor has prescribed A. Novocainamidum. . What is its medical effect? B. Chinidini sulfas.

A. Stimulation of 1-adrenoreceptors C. Nifedipinum. B. Stimulation of 2-adrenoreceptors D. Lidocainum. E. Aimalinum. C. Stimulation of 2-adrenoreceptors

D. Blockade of 1-adrenoreceptors 26. Acute cardiovascular insufficiency is accompanied by E. Blockade of 1-adrenoreceptors edema of . What medicine of group 20. Indicate the drug which is used as prophylactic agent of should be prescribed to the patient? bronchial asthma attacks: A. Acetazolamidum (Diacarbum). A. Adrenalini hydrochloridum. B. Spironolactonum. B. Euphyllinum. C. Dichlothiazidum. C. Cromolinum-sodium. D. Corglyconum. D. Aethimizolum. E. Triamterenum. E. Bromhexinum. 27. A patient with cardiogenic shock, hypotension, asthma, 21. A patient with chronic cardiovascular insufficiency during and edemas was prescribed a nonglycosidic cardiotonic. digitalization demonstrated the following symptoms: Which drug was injected to the patient? headache, fatigue, nausea, color vision impairment A. Coffeinum-natrii benzoas. (surrounding objects are perceived in green color). On B. Dobutaminum. ECG the sinus bradycardia and signs of impairment of C. Cordiaminum. atrioventricular conductivity were detected. What can be D. Aethimizolum. prescribed to relieve the symptoms of intoxication. E. Bemegridum. A. Dipiroximum. B. Naloxonum. C. Bemegridum. D. Unithiolum. E. Atropini sulfas.

22. Ventricular arrhythmia followed myocardial infarction of a patient. Cardiac rhythm was normalized by the introduction of antiarrhythmic drug with local anesthesia effect. What drug was prescribed. 2 28. A 68-year-old patient with cardiac insufficiency, who had B. Blockade of -adrenoreceptors of the myocardium. been taking Digitalis medicines for a long time, had C. Blockade of - and -adrenoreceptors of the symptoms of intoxication, which were quickly eliminated myocardium. by the application of the donator of the sulphhydric groups D. Blockade of calcium channels of the cardiomyocyte of unithiol. What is the mechanism of the therapeutic effect membranes. of this drug? E. Blockade of M-cholinoreceptors of the myocardium. A. Inhibition of potassium release from cardiac hystiocytes. B. Reduction of accumulation of ionized calcium. 34.Specify the cardiac glycoside which possesses the fastest C. Reactivation of Na/K-ATP-ase of cardiac hystiocytes onset of the action: membranes. A. Strophanthinum. D. Slowing-down of sodium coming into cardiac B. Celanidum (lanatosidum). hystiocytes. C. Digitoxinum. E. Increase of energy supply to the myocardium. D. Digoxinum. E. Adonisidum. 29. A cardiotonic drug was prescribed to a 50-year-old patient with chronic cardiac insufficiency and tachyarrhythmia. 35.What effect of cardiac glycosides is of greatest Which of these medicines was prescribed to the patient. importance? A. Dobutaminum. A. Increase of diuresis and elimination of edemas. B. Dophaminum. B. Increase of myocardium excitability. C. Digoxinum. C. Decrease of myocardium automatism. D. Amiodaronum. D. Decrease of myocardium conductivity. E. Mildronatum. E. Increase of myocardium contractility.

30. A patient with complaints of frequent pulse, dyspnea, 36.Indicate the mechanism of cardiotonic action of cardiac cyanosis of mucous tunics was hospitalized to a glycosides: cardiological department. Examination revealed edemas A. Excitation of -adrenoreceptors of myocardium. on the lower extremities, ascites. Chronic cardiac B. Activation of calcium channels of cardiomyocyte insufficiency was diagnosed. Which of the drugs should membranes. be prescribed to the patient? C. Inhibition of Na/K-ATP-ase of cardiac hystocytes A. Digitoxinum. membranes. B. Cordiaminum. D. Oppression of phosphodiesterase of cardiomyocytes. C. Adrenalini hydrochloridum. E. Activation of potassium channels of cardiomyocytes. D. Corglyconum. E. Drotaverini hydrochloridum. 37.Indicate the group of drugs which is the most expedient for treatment of paroxysmal atrial tachycardia: 31. A patient with pulmonary edema caused by acute left A. M-cholinoblockers. ventricular insufficiency patient was treated with cardiac B. Cardiac glycosides. glycoside. In 10-15 min, his condition improved and C. Na-channels blockers. maximal effect was in 1-1,5 hours, after that the action D. -adrenomimetics. gradually decreased. What drug has been injected? E. -adrenoblockers. A. Strophanthinum. B. Digoxinum. 38.Indicate the group of drugs, overdosage of which is C. Celanidum. accompanied by following signs: anorexia, nausea, vomiting, D. Digitoxinum. diarrhea, bradiarrhythmia, headache, vision impairment E. Adonisidum. (xanthopsia, diplopia). A. Ca-channels blockers. 32.Indicate the mechanism of antiarrhythmic action of B. Organic nitrates. Chinidini sulfas: C. Cardiac glycosides. A. Blockade of calcium channels of the cardiomyocyte D. -adrenoblockers. membranes. E. Angiotensin converting enzyme inhibitors. B. Blockade of sodium channels of the cardiomyocyte membranes. 39.Why do strophanthin and corglycon possess fast action C. Blockade of -adrenoreceptors of the myocardium. after the introduction into the organism? D. Blockade of - and -adrenoreceptors of the A. They have short half-life period. myocardium. B. They have high molecular weight. E. Blockade of M-cholinoreceptors of the myocardium. C. They have low molecular weight. D. They have high affinity to plasma proteins. 33.Specify the mechanism of antiarrhythmical action of E. They are not connected with plasma proteins and not Verapamile: biotransformated in organism. A. Blockade of sodium channels of the cardiomyocyte membranes.

3 40.What antiarrhythmic preparation does not belong to A. Natrii chloridum. membrane stabilizers? B. Metoprololum. A. Dipheninum. C. Octadinum. B. Amiodaronum. D.Clophelinum. C. Novocainamidum. E. Salbutamolum. D. Chinidini sulfas. E. Disopyramidum. 47. A 65-year-old patient felt retrosternal pain while waiting in a queue during the visit to a dermatologist. What drug is the most 41. A patient with angina pectoris developed bronchospasm effective in this case? after taking medicine. What drug could provoke it? A. Cordiaminum. A. Nifedipinum. B. Validolum. B. Nitroglycerinum. C. Sustac-forte. C. Sustac-forte. D. Nitroglycerinum. D. Dipyridamolum. E. Analginum. E. Propranololum. 48. A drug in the form of aerosol was prescribed to a patient 42. A doctor recommended a patient, who had an acute with angina pectoris. The patient had retrosternal pain and used myocardial infarction, to take acidum acetylsalicylicum in the an antianginal drug. The pain disappeared, but the patient began dose of 0.25 g once per 2 - 3 days during 3 - 4 months. What to complain of headache and vertigo. What drug has been used effect did the doctor count on? by the patient? A. Antiaggregant. A. Nitroglycerinum. B. Antiinflammatory. B. Propranololum. C. Antipyretic. C. Metoprololum. D. . D. Validolum. E. Vasodilative. E. Verapamilum.

43. A patient with ischemic disease has not informed the doctor 49. A patient who had been suffering from stable stenocardia that he had attacks of bronchospasm. The doctor prescribed a was treated with anapriline in the dosage of 0,02 g 3 times a day. drug, which has made the attacks of angina pectoris less fre- In a week the patient had felt better, but began to complaint of quent, but the attacks of bronchospasm have become more difficulty of respiration. Specify which drug from the group of frequent. What medicine has been prescribed? beta-adrenoblockers should be appointed instead anapriline. A. Atenololum. A. The antagonist of calcium – Verapamilum. B. Propranololum. B. Cardioselective beta-adrenobiocker – Metoprololum. C. Verapamilum. C. Long acting drug of nitroglycerine – Sustac-forte. D. Diltiazemum. D. The antagonist of calcium –Nifediplnum. E. Nitrosorbidum. E. Organic nitrate – Nitrogiycerinum.

44. A 53-year-old woman suffers from attacks. The patient 50. Determine an antianginal agent by its pharmacological is bothered by severe chest pain, arrhythmia and short breath. effect. It insignificantly improves coronary circulation What drug is the most expedient for prescription in this case to (especially in subendocardial layers), but the main cause of provide first aid? elimination of stenocardia is dilation of peripheral veins and A. Nitrosorbidum. arteries, that leads to decrease of cardiac work and myocardial B. Nitroglycerinum. oxygen demand. Besides, it oppresses the central links of C. Amiodaronum. cardiostimulating reflexes. D. Propranololum. A. Amiodaronum. E. Sustac-forte. B. Phenihydinum. C. Nitrogiycerinum. 45. Acidum acetylsalicylicum (75 mg, daily) is prescribed to a D. Validolum. patient, who had a myocardial infarction. With what purpose is E Anaplilinum. the drug prescribed? A. Reduction of body temperature. 51. A patient who had been suffering from stenocardia B. Reduction of inflammation. accompanied by cardiac arrhythmia (paroxysmal tachycardia) C. Reduction of pain. and arterial hypertension was admitted to the hospital. Specify D. Dilatation of coronary vessels. antianginal drug and the group which it belongs to, which E. Reduction of thrombocytes aggregation. should be administered taking into account the patient's diseases. 46. A 50-year-old man has appeal led to a doctor with A. β-adrenoblocker – Anaprilinum. complaints of chest pain, which occurs in the street, on his way B. Organic nitrate – Nitroglycerinum. to work, during physical activity. He has been ill for one year. C. Myotropic coronarodilating agent – Carbocromenum. The pain disappeared after taking validol, but recently its D. Caicium antagonist – Nifedipinum. application has become inefficient. What drug should be pre- E. Potassium channel activator - Nicorandilum. scribed? 4 52. Indicate the nitroglycerin's drug with prolonged action A. The substance is destroyed under the action of gastric juice. A. Natrii nitroprussidum. B. The substance is badly absorbed in the . B. Validolum. C The substance operates reflexly from oral cavity receptors. C. Amyl nitrite. D. The substance is being considerably destroyed during its D. Sustac-forte. first passage through the fiver. E. Dipiridamolum. E. It causes less side-effect in such way of introduction.

53. Indicate the drug which exerts antianginal action because of 60. Indicate the which belongs to the decrease of oxygen demand and increase of oxygen delivery to group of derivatives of phenylalkylamines: the myocardium. A. Nifedipinum. A. Nitrogiycerinum. B. Diltiazemum. B. Anapnlinum. C. Nicardipinum. C. Dipiridamolum. D. Clentiazemum. D. Talinololum. E. Verapamilum. E Carbocromenum. 61. Among special hypolipidemic agents the most effective ones are those which block synthesis of endogenous cholesterol in the liver. What drug from listed below has such mechanism of 54. Indicate the state which requires administration of action? nitroglycerine. A. Probucolum. A. Chronic cardiac insufficiency. B. Clofibratum. B. Acute cardiac failure. C. Cholestyraminum. C. Hypertensive crisis. D. Parmidinum. D. An attack of stenocardia. E. Lovastatinum. E. Endarteritis obliterans. 62. A patient has the family hypercholesterolemia. Indicate the drug which may be used due to ability to inhibit the main 55. Indicate the drug which should be used in the attack of enzyme of cholesterol synthesis? angina pectoris: A. Lovastatinum. A. Strophanthinum. B. Colestipolum. B. Bemegridum. C. Cholestyraminum. C. Nitrong D. Nicotinic acid. D. Benzohexonium. E. Probucolum. E. Nitroglycerinum. 63. Indicate the hypolipidemic agent which may be used in 56. Indicate the mechanism of action of nitroglycerine. atherosclerosis of brain arteries A. Release of NO groups which activate guanylyl cyclase. A. Cinnarizinum. B. Blockade of calcium channels. B. Lovastatinum. C. Blockade of adenosine receptors. C. Pyracetamum. D. Activation of adenylyl cyclase. D. Tocopheroli acetas. E. Inhibition of phosphodiesterase. E. Ascorbinic acid.

57. A patient with ischemic heart disease complaints of 64. Clofibrate was administered to a patient with worsening of his state that is caused by overdosage of anti- atherosclerosis. What is the most typical effect of this drug? anginal agent. What group of drugs can cause this state if it is A. Oppression of 3-hydroxy-3-methylglutaryl-cqenzyme A- known that concentration of methemoglobin in patients blood is reductase activity. increased? B. Increase of removal from the organism of the bile acids and A. Beta-adrenoblockers. cholesterol. B. Organic nitrates. C. Diminution of very low density apoproteins maintenance C. Blockers of calcium channels. in blood mainly. D. Activators of potassium channels. D. Antioxidant action. E. Myotropic coronary dilators. E. Angio-protective action.

58. After sublingual introduction of nitroglycerine its maximal 65. Specify the principle of antihyperlipidemic action of concentration in blood is developed in: lovastatine. A. 1 minute. A. Inhibition of synthesis of endogenous cholesterol in the B. 15 minutes. liver. C. 2-5 minutes. B. Impairment of creation of superoxide radicals. D. 30 minutes. C. Impairment of absorption of cholesterol in the intestine. E. 1 hour. D. Impairment of lipolysis in the fatty tissue. E. Impairment of binding of atherogenous lipoproteins with 59. Why are the tablets of nitroglycerine introduced sublingually endotneliocytes. only? 5 66. A patient with hypertensive disease with an accompanying D. Blockade of cyclooxygenase. obstructive receives propranolol in complex therapy. E. Blockade of calcium channels. After a while attacks of asthma occured. What is the cause of the side effect? 73. A doctor recommended a patient with chronic cardiac A. Blockade of β2-adrenoreceptors of bronchi. insufficiency and essential hypertension to include into the B. Blockade of β1-adrenoreceptors of bronchi. treatment regimen a potassium sparing diuretic, which is the C. Stimulation β2-adrenoreceptors of bronchi. antagonist of aldosterone, but its therapeutic effect develops D. Blockade of α2-adrenoreceptors of bronchi. slowly. Which of these drugs has been recommended to the E. Stimulation of α1-adrenoreceptors of bronchi. patient? A. Strophanthinum. 67. A patient suffers from hypertensive crisis. What is it B. Amiodaronum. necessary to prescribe to the patient for the normalization of C. Triamterenum. arterial pressure? D. Furosemidum. A. Propranololum. E. Spironolactonum. B. Reserpinum. C. Prazosinum. 74. One of antihypertensive drugs had been prescribed to a D. Atropini sulfas. patient with arterial hypertension. Arterial pressure was E. Magnesii sulfas. normalized, however, constant dry cough began to bother the patient. Which of the medicines possesses such side effect? 68. Increased renin level in the blood of a 55-year-old patient A. Nifedipinum. with hypertensive disease was detected. What hypotensive B. Propranololum. medicine should be preferred for the treatment of the patient? C. Clophelinum. A. Magnesii sulfas. D. Enalaprilum. B. Clophelinum. E. Reserpinum. C. Enalaprilum. D. Papaverini hydrochloridum. 75. The patient suffering from arterial hypertension with E. Prazosinum. hyperkinetic type of circulation and the high contents of renin, accompanied by stenocardia and sinus tachycardia has been 69. A patient with increased arterial pressure caused by treating for 10 years. Indicate the group of drugs should be peripheral vessels spasm is admitted to a therapeutics de- administered in this situation. partment. What hypotensive drug (the group of α-adrenoceptor A. β-adrenoblockers. antagonists) is the most expedient to be prescribed to the B. Organic nitrates. patient? C. α-adrenoblockers. A. Captoprilum. D. Sympatholytics. B. Prazosinum. E. Ganglioblockers. C. Aminazinum. D. Propranololum. 76. A 45 year old patient, who had been suffering from E. Clophelinum. idiopathic hypertension, was treated by an . After 4 days his arterial pressure decreased, but he 70. A patient with hypertensive disease has an attack of complained of sleepiness and psychological suppression. With bronchial asthma. What medicine should be taken to stop the which drug was the patient treated? attack? A. Captoprilum. A. Adrenalini hydrochloridum. B. Prazozinum. B. Isadrinum. C. Clophelinum. C. Salbutamolum. D. Enalaprilum. D. Aminophyllinum. E. Apressinum. E. Ephedrini hydrochloridum. 77. A patient had been suffering from hypertonic disease 71. A doctor has prescribed losartan to a patient with essential accompanied by chronic bronchitis with asthmatical component. hypertention. What pharmacological property of this drug Indicate the drug which is contraindicated due to it's action on provides therapeutic effect? the bronchi. A. Blockade of β-adrenoreceptors. A. Anaprilinum. B. Blockade of α-adrenoreceptors. B. Captoprilum. C. Blockade of angiotensin receptors. C. Prazosinum. D. Blockade of angiotensin-converting enzyme. D. Nifedipinum. E. Antagonism with calcium ions. E. Dichlothiazidum.

72. A patient with essential hypertension takes enalapril. What is the mechanism of the action of this drug? A. Blockade of angiotensin-converting enzyme. B. Blockade with angiotensin receptors. C. Blockade of phosphodiesterase. 6 78. A doctor has administered to a patient clonidine 84. A patient has been treated for a long time with cardiac (clophelinum) for elimination of hypertensive crisis. What class glycoside digoxinum in connection with congestive heart of hypotensive drugs does the named agent belong to? failure. Now the patient's state is stable, but there are remaining A. Peripheral neurotropic. edemas on the legs and face. What diuretic should be taken to B. Central neurotropic. avoid side-effects caused by simultaneous administration of C. Diuretics. cardiac glycosides and diuretics? D. Drugs affecting the renin-angiotensin system. A. Diacarbum. E. Myotropic (vasotropic) hypotensive agents. B. Mannitum. C. Dichlothiazidum. D. Spironoiactonum. 79. Indicate the drug which inhibits activity of vasomotor E. Urodanum. centre. 85. Which of the following drugs is an ACE inhibitor: A. Apressinum. A. Nifedipinum. B. Enalaprilum. B. Euphyllinum. C. Verapamilum. C. Diltiazemum. D. Clophelinum (clonidinum). D. Amlodipinum. E. Hydrochlorthiazidum (dichlothiazidum). E. Captoprilum.

80. Hypertensive crisis characterized by sharp headache, 86. Famotidine is prescribed to a patient with gastric ulcer. The dizziness, hyperemia of face, pains in the region of heart, rapid acidity of gastric juice has considerably decreased. What pulse, arterial pressure of 220/110 mm Hg has developed in a mechanism underlies the action of the drug? patient suffering from essential hypertension during the visit to A. Blockade of M-cholinoreceptors. the dentist. What agent is it necessary to introduce to the B. Blockade of H1-histaminic receptors. patient? C. Blockade of H2-histaminic receptors. A. Propranololum (Anaprilinum). D. Suppression of the activity of Na+/ K+-ATP-ase. B. Pirilenum. E. Blockade of N-cholinoreceptors in ganglions. C. Timololum. D. Furosemidum. 87. A 40-year-old patient suffers from gastric ulcer at the stage E. Clophelinum (clonidinum). of exacerbation accompanied by a substantial increase of the acidity of gastric juice, pain, and dyspeptic syndrome. Choose a 81. It was observed primary short-term increase of arterial corresponding drug: pressure in a patient after taking of a hypotensive agent. Indicate A. Allocholum. this preparation. B. Famotidinum. A. Prazosinum. C. Papaverini hydrochloridum. B. Reserpinum. D. Drotaverini hydrochloridum. C. Clophelinum (clonidinum). E. Platyphyllini hydrotartras. D. Propranololum (Anaprilinum). E. Hydrochlortniazidum (dichlothiazidum). 88. A patient complains of stomachache, heartburn. Tests revealed the increase of gastric juice acidity. What should be 82. The diuretic agent in dosage 0,025 g 2 times a day had been prescribed to the patient for the neutralization of the excessive prescribed to the patient with the beginning stage of idiopathic acidity of gastric juice? hypertension. In 7-8 days, the arterial pressure had slightly A. Benzohexonium. decreased, but he began to complain of pain in the heart region, B. Atropini sulfas. muscle weakness, and tremor. The analysis of blood has C. Papaverini hydrochloridum. revealed hypokalemia. Which from the listed drugs may cause D. Proserinum. this side effect. E. Almagelum. A. Mannitum. B. Spironolactonum. 89. A patient with biliary dyskinesia and constipations has been C. Triamterenum. prescribed a cholagogue, which has a significant effect. D. Amiloridum. What drug was prescribed by the doctor? E. Hydrochlorthiazidum (dichlothiazidum). A. Allocholum. B. Magnesii sulfas. 83. A patient had taken celanidum for long time due to chronic C. Cholosasum. heart failure. The physician administered to him D. Cholenzymum. dichlothiazidum to eliminate leg edemas. Which drug should be E. Chinidini sulfas. taken together with the diuretic to prevent hypokalemia? A. Unithiolum. B. Calcii chloridum. C. Pananginum. D. Calcii dobesilas. E. Magnii sulfas.

7 90. The patient was admitted to the hospital with the diagnosis: B. Misoprostolum. peptic ulcer of the duodenum bulbus. Analysis of his gastric C. Ranitidinum. juice revealed increased acidity. Choose the agent which D. Contrycalum. decreases the secretory ability of gastric glands due to blockade E. Drotaverini hydrochloridum (No-Spa). of H2-histaminic receptors. A. Ranitidinum. 97. Indicate the agent which may be used in an attack of biliary B. EXtracti Belladonnae. colic to relax smooth muscles? C. Atropini sulfas. A. Panzinormum. D. Methacinum. B. Atropini sulfas. E. Platyphyllini hydrotartras. C. Analginum. D. Pentazocinum. E. Cholosasum. 98. A 40 years old patient was admitted to the hospital with the biliary colic attack. What agent should be administered parenterally in this case? 91. A 25 year-old man, suffering from peptic ulcer of the A. Pancreatinum. stomach, has been treated with omeprasole. In 3 weeks the ulcer B. Almagelum. was healed. What mechanism of action does this drug produce? C. Drotaverini hydrochloridum (No-spa). A. Blockade of synthesis of Gastrin. D. Contrycalum. B. Blockade or M-cholinoceptors. E. Metoclopramidum. C. Blockade of H+ -K+ -ATP-ase (the proton pump). D. Blockade of Na+-K+-ATPase. 99. Indicate the drug from the group of myotropic spasmolytics E. Blockade of H2-histaminic receptors. which is suitable to eliminate pain in intestinal colic. A. Papaverini hydrochloridum. 92. Indicate the drug to stimulate appetite, mechanism of action B. Proserinum. of which is associated with of the membrane of C. Piridostigmini hydrobromidum. the oral cavity, which leads to reflex excitation of the hunger D. Pilocarpini hydrochloridum. center in the hypothalamus. E. Prazosinum. A. Fenfluraminum. B. Phepranonum. 100. Indicate a cholagogic agent used for treatment of chronic C. Desopimonum. cholecystitis. D. Tinctura Absinthii. A. Almagelum. E. Orlistatum. B. Tinctura Absinthii. C. Metoclopramidum. 93. A 32 year old patient had been suffering from the ulcer of D. Allocholum. the duodenal bulb was treated with Famotidine which caused E. Plathyphyllini hydrotartras. him to feel better. Indicate the mechanism of action of this agent. 101. Specify an agent from the group of hepatoprotectors which A. Inhibition of gastrin release. restores normal structure and function of hepatocytes, used in B. Blockade of H2-histaminic receptors. different liver deseases. C. Suppression of the function of the gastric mucosal cells. A. Allochoium. D. Decrease of release of hydrochloric acid. B. Tetracyclinum. E. Decrease of pepsin release. C. Cholenzymum. D. Tocopheroli acetas. 94. Indicate the mechanism of action of Phepranone. E. Essentiale. A. Oppresses the afferent endings of the vagus nerve. B. Blocks M- cholinoceptors. 102. Indicate the drug, which is used in chronic pancreatitis, C. Activates H2-histamine receptors in the stomach. accompanied by enzymes insufficiency, for improvement of D. Blocks N-cholinoceptors of vegetative ganglions. digestion processes. E. Inhibit hunger center. A. Festalum B. Pepsinum. 95. Indicate the synthetic drug increasing bile secretion: C. Ranitidinum. A. Drotaverini hydrochloridum (No-Spa). D. Pirenzepinum. B. Apomorphini hydrochloridum. E. Cholosasum. C. Cimetidinum. D. Oxaphenamidum. 103. Why is contrycal used in the case of acute pancreatitis? E. Almagelum. A. It opens Oddies sphincter. B. It inactivates trypsin which causes autolysis of pancreas. 96. Indicate the agent which stimulates contraction of gall C. It reduces the activity of hyaluronidase. bladder smooth muscle and causes evacuation of bile into the D. It impairs secretion of trypsinogen. intestine? E. It oppresses secretion or bile. A. Magnesium sulfas. 8 104. Indicate the drug used in acute pancreatitis to reduce B. Reduction of inflammation. autolysis of the gland. C. Reduction of pain. A. Pepsinum. D. Dilatation of coronary vessels. B. Chymotrypsinum. E. Reduction of thrombocytes aggregation. C. Pancreatinum. D. Contrycalum. 111. A pregnant woman's blood analysis revealed megaloblasts E. Fibrinolysinum. and a high Color Index. The diagnosis is megaloblastic anemia. What drug should be prescribed to the patient? 105. A 37-year-old man was admitted to the surgical department A. Acidium nicotinicum. with the symptoms of pancreatitis: vomiting, diarrhea, B. Pyridoxini hydrochloridum. bradicardia, hypotension, weakness, dehydration. What drug C. Acidium ascorbinicum. should be used first of all? D. Cyanocobalaminum. A. Drotaverini hydrochloridum. E. Coamidum. B. Famotidinum. C. Contrycalum. 112. Long cyancobalamine treatment was prescribed to a patient D. Platyphyllini hydrotartras. with megaloblastic anemia developed after gastroectomy. A E. Atropini sulfas. drug was injected intramuscularly. What advantage does the parenteral way have over the enteral? 106. A patient with thromboembolism of veins of lower A. The drug is quickly eliminated. extremities had been prescribed some medicine. In 2 days B. The drug is quickly absorbed. hemorrhages appeared on his skin. What drug can cause such C. The drug circulates in blood for a long time. complication? D. The drug is not metabolized in the liver. A. Neodicumarinum. E. This way is effective in the absence of gastromucoprotein. B. Dipyridamolum. C. Acidum acetylsalicylicum. 113. The patient was admitted to the traumatologic department D. Heparinum. due to fracture of chin , damages of soft tissues and E. Phenylinum. massive bleeding. Examination revealed paleness of the skin, pain in palpation of area of trauma, swelling of the skin, 107. After the examination of a 40-year-old man the diagnosis bleeding on the whole surface of the wound. Specify a drug for was made: hypochromic anemia. What drug should be local use to stop the bleeding. prescribed for treatment? A. Thrombinum. A. Cyanocobalaminum. B. Caicii chloridum. B. Fercovenum. C. Vikasolum. C. Pentoxylum. D. Acidum aminocapronicum. D. Heparinum. E. Fercovenum. E. Vikasolum. 114. Drugs delaying blood () are used 108. A doctor recommended a patient, who had an acute for prevention and treatment of thrombosis. Specify an myocardial infarction, to take aside acetylsalicylice in the dose which antagonist is protamine sulfate. of 0.25 g once per 2 - 3 days during 3 - 4 months. What effect A. Phenilinum. did the doctor count on? B. Neodicumarinum. A. Antiaggregant. C. Syncumarum. B. Antiinflammatory. D. Heparinum. C. Antipyretic. E. Natrii hydrocitras. D. Analgesic. E. Vasodilative. 115. A patient was delivered to a hospital with complaints of loss of appetite, decrease of body weight, fatigue, pain around 109. An 8-year-old child is being prepared for tonsilectomy. The the epigastric area. Examination of the blood revealed analysis of blood has shown that the time of blood coagulation megaloblastic anemia. Specify the main agent for the treatment is increased (up to 7 minutes). What drug should be included (5 of this disease. days before the operation) into the complex of therapeutic A. Ferri lastas. agents of the preparatory period first of all? B. Cyanocobalaminum. A. Acidium aminocapronicum. C. Acidum acethylsalicylicum. B. Natrii chloridum. D. Fercovenum. C. Vikasolum. E. Coamidum. D. Fibrinogenum. 116. Specify the antagonist of the anticoagulants with indirect E. Alteplasum. action. A. Pentoxylum. 110. Acidum acetylsalicylicum (75 mg, daily) is prescribed to a B. Fercovenum. patient, who had a myocardial infarction. With what purpose is C. Vikasolum. the drug prescribed? D. Protamini suifas. A. Reduction of body temperature. E. Contrykalum. 9 117. Specify the coagulant agent available for local use only (to 125. Indicate the mechanism of streptokinase action: stop bleedings from small blood vessels). A. Inhibition of synthesis of the clotting factors in the liver. A. Hemostatic sponge. B. Inhibition of thrombin. B. Vikasolum. C. Inhibition of the conversion of prothrombin to thrombin. C. Calcii chloridum. D. Inhibition of proteolytic enzymes. D. Fibrinogenum. E. Facilitate the conversion of plasminogen to plasmin. E. Aminocapronic acid. 126. A patient, who has a mastectomy because of the mammary 118. Inhibition of leukopoiesis is observed in a 43 years old gland cancer, is prescribed a course of radiotherapy. What roentgenologist. Specify the agent to be used for stimulation of drug has antiradiation effect caused by antioxidant leucopoiesis. activity? A. Acidum ascorbinicum. A. Cyanocobalaminum. B. Fercovenum. B. Ergocalciferolum. C. Acidum folicum. C. Riboflavinum. D. Cyanocobalaminum. D. Tocopheroli acetas. E. Pentoxylum. E. Acidi follicum.

119. Indicate the cumarine derivatives, anticoagulant of indirect 127. Tetany has developed after thyreoidectomy. Using what action: drug is it possible to eliminate the problem? A. Heparinum. A. Triiodothyroninum. B. Syncumar. B. Calcii chloridum. C. Dipyridamolum. C. Mellictinum. D. Vikasolum. D. Calcitrinum. E. Thrombinum. E. Ergocalciferolum.

120. Antagonist () of heparine is: 128. A 39-year-old man appealed to a hospital. Recently he A. Syncumar. noticed susceptibility to infectious diseases and impairment of B. Protamini sulfas. twilight vision. During the examination a doctor diagnosed C. Vikasolum. hyperkeratosis. What vitamin drug should be prescribed? D. Alteplasum. A. Pyridoxini hydrochloridum. E. Calcii chloridum. B. Retinoli acetas. C. Riboflavinum. 121. A patient with hypochromic anemia has splitting and loss D. Ergoealciferolum. of hair, increased nail brittleness and taste alteration. What is the E. Tocopheroli acetas. mechanism of the symptoms development? A. Decreased production of calcitonine. 129. A patient came to a doctor with complaints of twilight B. Deficiency of vitamin A. adaptation impairment (night blindness). What vitamin drug is C. Deficiency of iron-containing enzymes. to be prescribed to the patient for the restoration of his sight? D. Decreased production of . A. Thiamini chloridum. E. Deficiency of vitamin B12. B. Vikasolum. C. Pyridoxini hydrochloridum. 122. Indicate the mechanism of action of heparine: D. Retinoli acetas. A. Inhibition of synthesis of the clotting factors in the liver. E. Tocopheroli acetas. B. Inhibition of thrombin. C. Inhibition of the conversion of prothrombin to thrombin. 130. The deficiency of prothrombin in blood was detected D. Activation of profibrinolysin. during a preoperative examination of a patient. What drug is E. Causes proteolysis of plasminogen molecules to plasmin. needed for the preliminary use by the patient for reducing blood loss during operation? 123. Indicate the clinical use of cyanocobalamine: A. Phenylinum. A. Leucopoenia. B. Thrombinum. B. Malignant megaloblastic anemia. C. Acidum aminocapronicum. C. Acute leucosis. D. Vicasolum. D. Gout. E. Contrycal. E. Thyrotoxicosis.

124. Indicate the drug used locally for the arrest of hemorrhages from small vessels: A. Calcii chloridum. B. Heparinum. C. Protamini sulfas. D. Thrombinum. E. Vikasolum. 10 131. A patient who had been taking a vitamin drug for the 137. Hydroxilation of endogenous substrates and xenobiotics prevention of cerebrovascular spastic reactions began to requires a donor of protons. Which of the following complain of unpleasnt feelings: hyperemia of the face and upper can play this role? part of the body, vertigo, feeling of blood influx into the head. A. Vitamin C. What drug may cause these side-effects. B. Vitamin A. A. Acidum nicotinicum. C. Vitamin P. B. Tocopheroli acetas. D. Vitamin B6. C. Nicotinamidum. E. Vitamin E. D. Thiamini bromidum. E. Calcii pangamas. 138. A patient suffers from chronic alcoholism with the following 132. A patient had been taking vitamin D for a long time for symptoms: pain in arms and legs, impairment of skin sensitivity, treatment of rickets. Soon the signs of vitamin D intoxication muscle weakness, edemas and increased amount of pyruvate. developed: loss of appetite, nausea, headache, fatigue, increase Which vitamin drug should be prescribed to the patient? of body temperature, etc. What vitamin decreasing the toxic A. Ergpcalcipherolum. influence of vitamin D should be administered? B. Thiamini chloridum. A. Vitamin A. C. Retinoli acetas. B. Vitamin C. D. Rutinum. C. Vitamin B1. E. Vicasolum. D. Vitamin PP. E. Vitamin B6. 139.Which of the acids below decreases permeability of connective tissue structures, possesses antioxidant activity due 133. A 55 year old patient was admitted to the haemotological to ability to be transformed from the oxydized form into reduced department with signs of acute anemia. After laboratory and on the contrary? examination megaloblastic hyperchromic anemia was A. Aspirinum. diagnosed. Which drug must be administered to the patient first B. Hydrochloric acid. of all? C. Mefenamic acid. A. Cyanocobaiaminum. D. Ascorbinic acid. B. Vitamin B1. E. Aminocapronic acid. C. Ferroplexum. D. Ferrum-Lek 140. Radiation therapy is performed to the patient. What vitamin E. Acidum folicum. drug with antioxidant properties is necessary for administration to increase stability of tissues in this case? 134. A 55 year old patient suffering from hyperchromic anemia A. Thiamini chloridum. obtained long-term treatment with vitamin B12 parenterally. B. Vitamin B6. Why the parenteral way of introduction of vitamin B12 is C. Ascorutinum. prefered more than the peroral way? D. Cyanocobalaminum. A. It isn 't absorbed in the intestine in oral introduction due E. Acidum folicum. to deficit of gastromucoprotein. B. It is faster absored. 141. The patient who was treated by a vitaminic drug for C. It is longer circulated in the blood. prophylaxis of vasospasms of the brain, has developed D. It is faster penetrated to the marrow. complaints of the unpleasant sensations related to taking of this E. It isn't destroied in the liver. medicine: reddening of the face and the upper half of a trunk, giddiness, of flush of blood to a head. For what drug the 135. A patient has diarrhoea, and dermatitis. What specified side-effects are characteristic? vitamin has to be included into the complex pharmacotherapy? A. Tocoferoli acetas. A. Nicotinic acid. B. Nicotinamidum. B. Thiaminum. C. Thiamini bromidum. C. Cyanocobalaminum. D. Acidum nicotinicum. D. Panthotenic acid. E. Calcii pangamas. E. Riboflavinum. 142. What vitamin promotes growth and development of 136. There is an inhibited coagulation in the patient with bile epithelial cells, including epidermal ones? ducts obstruction, bleeding due to the low level of absorbtion of A. Retinoli acetas. a vitamin. What vitamin is in deficiency? B. Ergocalciferolum. A. Vitamin K. C. Acidum ascorbicum. B. Vitamin D. D. Acidum nicotinicum. C. Carotin. E. Lipoic acid. D. Vitamin. E. Vitamin E.

11 143. To the child with signs of rachitis the pediatrist and the B. Insulinum of average duration action. dentist administered a liposoluble vitamin which influences an C. Insulinum of brief action. exchange of phosphorus and calcium in an organism, promotes D. Metforminum. sedimentation of calcium in bone tissue and dentine. Determine E. Glibutidum. a drug. A. Retinoli acetas. 150. A patient with rheumatoid arthritis had been taking B. Tocoferoli acetas. glucocorticosteroid during several weeks. Then he suddenly C. Ergocalciferolum. stopped taking these drugs. What complication can occur in this D. Vicasolum. case? E. Thyreoidinum. A. Hyperglycemia. B. Hypertension. 144. A doctor administered tocoferol acetate to a patient with C. Withdrawal syndrome. ischemic heart disease. What effect of a drug does the doctor D. Exacerbation of chronic processes. expect? E. Formation of ulcers on the mucous coat of the stomach and A. Hypotensive. duodenum. B. Spasmolytic. C. Antioxidant. 151. Because of a long-term application of a drug such D. Increase of oxygen delivery to myocardium. complications as osteoporosis, erosive ulcers of the mucous coat E Positive inotropic. of stomach, edemas, increase of arterial pressure, insomnia have developed. Laboratory tests detected hypernatremia, 145. What enzymatic drug is used with the purpose of dropping hypokalemia and hyperglycemia. What drug has been applied? of density and rising of permeability of connective tissue A. Digoxinum. structures? B. Hypothiazidum. A. Amylasum C. Prednisolonum. B. Lipasum D. Indometacinum. C. Carboxylasum. E. Reserpinum. D. Cholinesterasum. E. Lidasum. 152. The condition of a patient with diabetes worsened after a routine injection of insulin. There was anxiety, cold sweat, 146. Cardiac arrhythmia, expressed muscle weakness, diarrhea, tremor of limbs, general weakness, loss of consciousness. What vomiting, impairment of vision, headache have developed to the drug is a pharmacological antagonist of insulin? patient under the treatment by digitoxin. What drugs can A. Adrenalini hydrochloridum. attenuate the above-mentioned phenomena? B. Butamidum. A. Drugs of potassium. C. Coffeinum-natrii benzoas. B. Drugs of calcium. D. Noradrenalini hydrotartras. C. Iron preparations. E. Glibutidum. D. Drugs of sodium. E. Drugs of magnesium. 153. An endocrinologist has prescribed glibenclamide to a patient with type II diabetes. What is the basic mechanism of 147.Which of plasma substitutes listed below circulates in the this drug action? blood for a long time? A. Increasing of glucose . A. Rheopolyglucinum. B. Depression of gluconeogenesis. B. 5 % Glucose Solution. C. Stimulation of insulin secretion by β-cells of Langerhans' C. 0,9 % solution of Sodium chloride. islets. D. Ringer-Locke solution. D. Enchancement of glucose capture by peripheral tissues. E. Polydesum. E. Activation of glucose transport into the cell.

148. A patient with hypothyroidism was treated with a drug — 154. Type II diabetes was revealed during an examination of a synthetic sinistrorotatory thyroxin . The following 70-year-old patient. What drug is expedient for use in this case? concomitant complications are possible: tachycardia, A. Cortisonum. arrhythmia, trembling of the limbs. Which of the listed drugs B. Insulinum. has such action? C. Mercazolilum. A. Retabolilum. D. Parathyreoidinum. B. Ergocalciferolum. E. Glibenclamidum. C. Mercazolilum. D. Levothyroxinum. 155. Having a serious infection a patient needs an anabolic drug E. Prednisolonum. for the improvement of appetite. Which one? A. Heparinum. 149. Diabetic coma has been diagnosed. Concentration of sugar B. Thiamini chloridum. in blood is 18.44 millimole/l. What drug with glucose C. Tinctura Absinthii. decreasing effect should be prescribed to this patient? D. Retabolilum. A. Insulinum of prolonged action. E. Acidi folicum. 12 156. A medicine was prescribed for the treatment of arthritis. It 163. Insulin was introduced to the patient, suffering from has the following pharmacological characteristics: it increases diabetes mellitus. What is the main mechanism of action of this the production of lipomodu-line, reduces phospholipase A2 agent? activity, reduces the synthesis of arachidonic acid metabolism A. Oppression of giycogenesis. products (cyclic endoperoxides, ). What drug is B. Activation of glucose transport from blood to tissues. this? C. Inhibition of transport of aminoacids. A. Isadrinum. D. Activation of synthesis of triglycerides. B. Adrenalini hydrochloridum. E. Activation of glycogen synthesis. C. Prednisolonum. D. Butadionum. 164. The state of the patient, suffering from diabetes mellitus E. Glibenclamidum. was worsened after the injection of insulin: general asthenia, cold sweat, tremor of extremities developed. What drug should 157. A drug oppressing enzymatic systems, participating in be used in this situation? synthesis of hormones of thyroid gland was administered to a 47 A. Butamidum. years old patient, suffering from thyrotoxicosis. Indicate this B. Hydrocortisoni acetas. drug. C. Glucosum. A. Triiodthironini hydrochloridum. D. Noradrenalini hydrotartras. B. Sol. Lugoli. E. Metforminum. C. Mercazolilum. D. L-Thyroxinum. 165. Indicate the synthetic antidiabetic drug from the group of E. Radioactive iodine. biguanide derivatives. A. Butamidum. 158. Specify a synthetic analogue of hormones. B. Acarbosa. A. Prednisolonum. C. Metforminum. B. Adrenalinum. D. Glibenclamidum. C. Pituitrinum. E. Glipizidum. D. Fluorocortisonum. E. Testosteronum. 166. The doctor has administered an ointment containing glucocorticoid to the patient suffering from allergic dermatitis. 159. A woman, 28 years old, was admitted to a hospital in The advantage of this drug is - it is not absorbed into the blood relation with danger of miscarriage. Earlier she had two cases of from the skin. Specify this drug. preliminary labor. Specify the drug of the hormone of corpus A. Hydrocortisoni acetas. luteum that needs to be introduced in this case. B. Dexamethasonum. A. Progesteronum. C. Beclomethasoni dipropionas. B. Synoestrolum. D. Flumethasoni pivalas. C. Diazepamum. E. Prednisolonum. D. Magnii sulfas. E. Tocopheroli acetas 167. The patient of 45 years complains of constant thirst and expressed polyuria. The level of glucose in blood plasma is 160. Specify the drug of posterior pituitary hormone applied to normal, and in urine glucose misses. What drug should be stimulation of labor activity of uterus. chosen for his treatment? A. Progesteronum. A. Insulinum. B. Synoestrolum. B. Dexamethasonum. C. L-Thyroxinum. C. Adiurecrinum D. Oxytocinum. D. Hydrocortisoni acetas. E. Salbutamolum. E. Prednisolonum.

161. What hormonal drug is used for treatment of diabetes 168. A 40-year-old woman appealed to a doctor with a insipidus? complaint of pain in the knee . During examination the A. Hydrocortisoni acetas. doctor revealed swelling, reddening, hyperthermia in these joints B. Desmopressinum. area. Laboratory tests showed positive acute phase reactants. C. L-Thyroxinum. What drugs have to be used for the treatment of the patient? D. Oxytocinum. A. Narcotic analgesics. E. Insulinum. B. Antiinflammatory agents of nonsteroid structure. 162. Mercazolilum had been administered to the patient, C. . suffering from thyrotoxicosis. What effect underlies antithyroid D. . activity of a drug? E. Sulfanamides. A. Depression of production of thyrotropic hormone. B. Decrease of thyroid hormones production. C. Depression of uptake of iodine by thyroid gland. D. Destruction of cells of thyroid gland. E. Oppression of metabolism in thyroid gland. 13 169. A patient with rheumatoid arthritis had been taking antihistamine drug should be administered to a patient, taking glucocorticosteroid during several weeks. Then he suddenly into account his profession? stopped taking these drugs. What complication can occur in this A. Diazolinum. case? B. Dimedrolum. A. Hyperglycemia. C. Diprazinum. B. Hypertension. D. Suprastinum. C. Withdrawal syndrome. E. Ketotifenum. D. Exacerbation of chronic infection processes. E. Formation of ulcers on the mucous coat of the stomach and 176. After prolonged taking of a drug in relation with acute duodenum. a patient began to complain of headache, vertigo, noise in ears, nausea, epigastric pain. Specify this drug 170. A 62-years-old man has been suffering from coxitis for a that might cause such clinical picture. long time. A doctor prescribed him a new nonsteroid A. Acetylsalicylic acid. antiinflammatory agent celecoxib. It improved the patient's B. Vitamin C. state. What is the advantage of this drug? C. Prednisolonum. A. Depression of choline esterase. D. Bromhexinum. B. Depression of phosphodiesterase. E. Midantanum. C. Activation of adenylate cyclase. D. Selective blockade of cyclooxygenase-2. 177. Which drug is the most preferable for local treatment of E. Activation of phosphodiesterase. allergic dermatitis? A. Hydrocortisoni acetas. 171. Allergic dermatitis produces itching, hypostasis, reddening, B. Paracetamolum. and insomnia. What drug is expedient for prescribing to the C. Furacilinum. patient? D. Methylsalicylas. A. Dimedrolum. E. Ichthyolum. B. Phenobarbitalum. C. Nitrazepamum. 178. The doctor has administered an ointment containing anti- D. Chlorali hydras. inflammatory agent from the group of pyrazolone derivatives to E. Natrii oxybutyras. the patient with arthritis of maxillofacial . What agent is contained in the ointment? 172. A patient has urticaria, which is treated with dimedrol. A. Butadionum. Which element of allergy pathogenesis is the therapeutic effect B. Acidum mefenamicum. of dimedrol connected with? C. Ibuprofenum. A. Synthesis of immunoglobulins. D. Indomethacinum. B. Histamine secretion. E. Diclofenac-natrium. C. Formation of the antigen-antibody complex. D. Interaction of histamine with receptors in organs. 179. Indicate the drug from the group of nonsteroid anti- E. Activation of B-lymphocytes. inflammatory agents which exerts the most prominent anti- inflammatory action in collagenoses? 173. For treatment of joints arthritis a physician prescribed a A. Butadionum. drug which belongs to nonsteroid antiinflammatory medicines. B. Aspirinum. It mainly influences cyclooxy-genase-2. It has no irritative C. Ibuprofenum. influence on the mucous coat of the digestive system. What drug D. Indomethacinum. is it? E. Diclofenac-natrium. A. Indometacinum. B. Celecoxibum. 180. Reduce of influence on which molecular substrate leads to C. Diclofenac-natrium. decrease of ulcerogenic action of nonsteroid anti-inflammatory D. Acidum acetylsalicylicum. agents? E. Ibuprofenum. A. Cyclooxygenase-2. B. Kallikreine. 174. A second generation antihistaminic drug is a derivative of C. Lysosomal enzymes. piperidine, taken once a day. It has no M-anti-cholinergic and D. Cyclooxygenase-l. adrenergic blocking effect. It shows antiallergenic, E. Adenylate cyclase. antiexudative, action. What drug is this? A. Retinoli acetas. B. Dimedrolum. C. Diazolinum. D. Suprastinum. E. Loratadinum.

175. A 40 year-old patient working as a driver suffers from chronic conjunctivitis of an allergic genesis. Which 14 181. The 63 years old patient with arthritis on a background of he began to complain about muscle weakness, skin treatment by aspirin (acetytsalicylic acid) has complained of sensitivity, vision disorder, and movement’s coordination nausea, gravity in epigastrium. The doctor has abolished aspirin disorder. Which of the following should be recommended? and has administered the antiinflammatory agent from the group A. Vitamin B12 of selective COG -2 inhibitors. Indicate this drug. B. Vitamin A A. Butadionum. C. Vitamin D B. Diclofenac-natrium. D. Vitamin B6 C. Indomethacinum. E. Vitamin C D. Acidum mefenamicum. E. Meloxycamum. 189. A 25-year-old woman during a month was keeping a diet to 182. Indicate "day time" antihistaminic agent (with the least loose weight. The diet was of two cups of coffee without expressed sedative and activity). sugar, three dried crusts, and two sausages or two eggs per A. Dimedrolum. day. She lost 5 kilograms and developed bad headache, B. Diprazinum. nosebleed, gingival hemorrhage, loosening of teeth, C. Tavegilum. desquamation. Which vitamin drug would be appropriate in D. Suprastinum. this case? E. Diazolinum. A. Acidum folicum B. Cyanocobalaminum 183. A girl was treated with from the group of C. Acidum ascorbinicum semisynthetic Penicillins due to acute bronchitis. On the 3rd day D. Retinolum of treatment allergic dermatosis has developed. Indicate an E. Vikasolum antiallergic drug which should be administered to the patient. A. Suprastinum. 190. Abnormality of bone calcification, deformation of spinal B. Analginum. column and thorax, and deviation of lower extremities are C. Aspirinum. observed in a 3-year-old child. Which drug is the most D. Biseptolum. effective in this case? E. Mefenamic acid. A. Thiaminum 184. Indicate the group of antiallergic agents to which loratadine B. Tocopheroli acetas belongs. C. Ergocalciferolum A. . B. Membrane stabilizers. D. Glucosum C. Antagonists of leucotriene receptors. E. Adiurecrinum D. Blockers of histamine receptors. E. Blockers of serotonine receptors. 191. As a result of uncontrolled ingestion of a vitamin drug a child developed anorexia, nausea, vomiting, diarrhea, 185. The immunodepressive effect of Prednisolone is caused by: hyperthermia and meningism. Hematomas on skin and A. Inhibition of protein synthesis due to activation of mucous coats appeared. Which drug was the child tacking? gluconeogenesis. A. Retinolum B. Inhibition of collagen synthesis. B. Somatotropinum C. Activation of synthesis of inhibitors of proteases. C. Nicotinamid D. Inhlbition of synthesis of mucopolysaccharides. D. Rutinum E. Diminution of activity of pfasmin. E. Tocopheroli acetas 186. A 48 years old woman who is suffering from exacerbation of chronic pneumonia requires treatment with 192. A woman complained to a pediatrician that her 8-month-old agent. Indicate this drug. child was having anxiety, two wide fontanel, and retarded A. Sulfocamphocainum. teeth eruption (only two teeth). Which drug shall be B. Thymalinum. prescribed first of all? C. Biseptolum. A. Calcii pangamas D. Dimedrolum. B. Thiaminum E. Levamisolum. C. Cyanocobalaminum D. Acidum folicum 187. Indicate the immunostimulant drug which is also well E. Ergocalciferolum known as agent. 193. A patient is having dementia, diarrhea, and dermatitis. A. Levamisolum. Pellagra is diagnosed. Which vitamin should be used for B. Interferonum. treatment? C. Methyluracilum. A. Acidum nicotinicum D. Pyrantelum. B. Thiaminum E. Natrii nucleinas. C. Tocopheroli acetas

D. Cocarboxylasum 188. A patient diagnosed with focal tuberculosis is taking E. Riboflavinum isoniazidum as part of combined . In some time 15