Anti-MAML2 Polyclonal Antibody (CABT-BL2262) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Anti-MAML2 polyclonal antibody (CABT-BL2262) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Immunogen Synthetic peptide, corresponding to a region between residue 1100 and the C-terminus (residue 1153) of Human MAML2 (AAK93831.1). Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Immunogen affinity purified Conjugate Unconjugated Applications IHC-P Cellular Localization Nucleus speckle. Nuclear, in a punctate manner. Format Liquid Buffer 0.1% BSA, Tris buffered saline Preservative 0.09% Sodium Azide Storage Store at +4°C. BACKGROUND Introduction Diphtheria is a bacterial infectious disease which appears predominantly during the childhood. The disease leads particularly to an inflammation of the pharynx, larynx and nasal mucosa. The etiologic agent is the Corynebacterium diphtheriae. Its pathogenicity is based on the secretion of an exotoxin that is circulating in the blood and effecting the heart muscle, kidneys and CNS. Only the toxigenic strains are pathogenic. Depending on the stage of disease, the three types 'slight, middle and serious' can be distinguished. The grade of disease depends on the immune status of the child. Usually, a limited Diphtheria arises, whereas in case of an immune suppression, a severe Diphtheria is observed. As a result of this course of disease, the patient may die. In most cases children will be vaccinated (e.g. DTP = Diphtheria-Tetanus-Pertussis) after the third month of life. The state of immunity can be monitored by determining the antitoxin IgG. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved GENE INFORMATION Entrez Gene ID 84441 Protein Refseq NP_115803 UniProt ID Q8IZL2 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

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A Systems Genomics Approach to Uncover Patient-Specific Pathogenic Pathways and Proteins in a Complex Disease
bioRxiv preprint doi: https://doi.org/10.1101/692269; this version posted July 4, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in a complex disease 1,2,3,4,§ 5,§ 1,4,6,§ 4,7 Johanne Brooks , Dezso Modos , Padhmanand Sudhakar , David Fazekas , Azedine 5 8 4 1,4 6,9 Zoufir , Orsolya Kapuy , Mate Szalay-Beko , Matthew Madgwick , Bram Verstockt , Lindsay 1,2 1,2,3 3 10 6,9 Hall Alastair Watson , Mark Tremelling , Miles Parkes , Severine Vermeire , Andreas 5 1,2,* 1,4,* Bender , Simon R. Carding , Tamas Korcsmaros 1 Gut Health and Microbes Programme, The Quadram Institute Bioscience, Norwich Research Park, Norwich, UK 2 Norwich Medical School, University of East Anglia, Norwich, UK 3 Department of Gastroenterology, Norfolk and Norwich University Hospitals, Norwich, UK 4 Earlham Institute, Norwich Research Park, Norwich, UK 5 Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK 6 KU Leuven, Department of Chronic diseases, Metabolism and Ageing, Leuven, Belgium 7 Department of Genetics, Eötvös Loránd University, Budapest, Hungary 8 Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary 9 University Hospitals Leuven, Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium 10 Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. § equal contribution * joint corresponding authors bioRxiv preprint doi: https://doi.org/10.1101/692269; this version posted July 4, 2019.
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