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Drug-Induced Immune Thrombocytopenia Results of the Testing for Drug-Dependent -Reactive by the BloodCenter of Wisconsin

Data are from 1995-2018, provided with the permission of Daniel Bougie PhD, Janice McFarland MD, Brian Curtis, PhD and Richard Aster, MD

[+]: Indicates drugs for which drug-dependent platelet reactive antibodies [DDAb] were detected. [-]: Indicates drugs for which samples were submitted for testing but no DDAb were detected * Indicates drugs for which DDAb were identified in ten or more patients. ¹Indicates drugs for which DDAb were detected only with drug metabolites. ²Indicated drugs for which DDab were dected for both intact, parent drug and metabolites. Information about DDAb testing is available from the Platelet Neutrophil Laboratory ( https://www.versiti.org/medical-professionals/precision-medicine-expertise/platelet-white-cell- disorders)

DRUG DDAB * + * + * + * + *OXALIPLATIN + * + * + *PIPERACILLIN/ + * + * + *RIFAMPIN + *SULFAMETHOXAZOLE/ + *TIROFIBAN + * +

ACETAMINOPHEN + ACETAMINOPHEN/HYDROCODONE - ACETAMINOPHEN/OXYCODONE - ACETAMINOPHEN/PROPOXYPHENE - ACYCLOVIR - ALBUTEROL - ALENDRONATE - - ALPRAZOLAM - DRUG DDAB + + - AMLODIPINE/BENAZEPRIL - + AMOXICILLIN/CLAVULANATE - - + + + + ATORVASTATIN - ATOVAQUONE - + AZITHROMYCIN - + BENAZEPRIL - BENZTROPINE - - BUDESONIDE - + + - - CARBIDOPA - - CASPOFUNGIN - + + + + + + CEFTRIAXONE + - CELECOXIB + CEPHALEXIN + - - CILASTATIN/ - DRUG DDAB - + CITALOPRAM - - CLAVULANATE POTASSIUM - + CLONAZEPAM - - - - CYCLOSPORINE + DAPSONE - + + - DICLOFENAC - DIGOXIN - - + + - DONEPEZIL - - - + ENALAPRIL - ENOXAPARIN - EPOETIN ALFA - ESCITALOPRAM - ESOMEPRAZOLE + ETHAMBUTOL + /NORGESTIMATE - ETHOXISUXIMIDE + EXENATIDE + EZETIMIBE - FAMOTIDINE - FELBAMATE + + FENOFIBRATE - + DRUG DDAB FEXOFENADINE + - - - - FLUVASTATIN - - + - GENTAMICIN - - - GLYBURIDE - + - - HYDROCHLOROTHIAZIDE/LOSARTAN - - HYDROMORPHONE - HYDROXYCHLOROQUINE + IBRUTINIB + + IMIPENEM (see CILASTATIN/IMIPENEM) - INSULIN - IPRATROPIUM - IRBESARTAN - IRINOTECAN + - ISOSORBIDE - - - + LANSOPRAZOLE + - LEUCOVORIN + - LEVOFLOXACIN + - - DRUG DDAB - LISINOPRIL + - + - + LOSARTAN + - LOVASTATIN/ - - MELOXICAM - - METFORMIN - - - METHYLPHENIDATE - + METOCLOPRAMIDE - - - + MIDAZOLAM - MILRINONE - - - - - - MOXIFLOXACIN - MYCOPHENOLATE - + NAPROXEN + - - NITROFURANTOIN + NITROGLYCERIN - NIZATIDINE + - NYSTATIN - + DRUG DDAB OLMESARTAN + - ONDANSETRON + - OXAPROZIN + + OXYCODONE - + + + - + PIOGLITAZONE - PRAVASTATIN - PREDNISONE - - + PROPOXYPHENE + + PROPYLTHIOURACIL + PROTAMINE + + QUINAPRIL - RABEPRAZOLE - RALOXIFENE - RAMIPRIL - + RIFABUTIN - RIFAXIM + RISEDRONIC ACID - - RITUXIMAB + ROSUVASTATIN - SERTRALINE + SILDENAFIL - + - + SUCRALFATE - SULFISOXAZOLE + DRUG DDAB + + - - - - TOBRAMYCIN - - - TRAMADOL - + - TRIAZOLAM - TRIMETHOPRIM + URSODIOL - VALACYCLOVIR - - VALPROIC ACID + VALSARTAN - VENLAFAXINE - + VORICONAZOLE + WALNUTS (ENGLISH) + - ZOLMITRIPTAN + -