Oral Presentations September 23Rd - Rooms 1,2 and 3

Total Page:16

File Type:pdf, Size:1020Kb

Oral Presentations September 23Rd - Rooms 1,2 and 3 Oral Presentations September 23rd - Rooms 1,2 and 3 Presentation Date Abstract Authors Presenter´s name - Theme Title Code indicated by the author 18498 Thomas Smits; Femke Gresnigt; Thomas Smits Clinical Toxicology/drugs of PERFORMANCE OF AN IMMUNOASSAY Eric Franssen; Milly Attema-de abuse METHOD FOR GAMMA-HYDROXYBUTYRIC Jonge ACID (GHB) IN PATIENTS PRESENTED AT THE EMERGENCY DEPARTMENT, A PROSPECTIVE STUDY 18499 Thomas Smits; Femke Gresnigt; Thomas Smits Clinical Toxicology/drugs of DO WE NEED POINT-OF-CARE TESTING OF Milly Attema-de Jonge; Eric abuse GAMMA-HYDROXYBUTYRIC ACID (GHB) AT Fransse THE EMERGENCY DEPARTMENT? September 23 18730 Lilian H.J. Richter; Julia Menges; Lea Wagmann Clinical Toxicology/drugs of NEW PSYCHOACTIVE SUBSTANCES: Lea Wagmann; Simon D. Brandt; abuse METABOLIC FATE, ISOZYME-MAPPING, 13:30 - 14:45 Folker Westphal; Veit Flockerzi; AND PLASMA PROTEIN BINDING OF 5-APB- ROOM 1 Markus R. Meyer NBOME, 2C-B-FLY-NB2ETO5CL, AND 2C-B- FLY-NBOME 18985 Annelies Cannaert; Marie Annelies Cannaert Clinical Toxicology/drugs of HIDE AND SEEK: OVERCOMING THE Deventer; Melissa Fogarty; abuse MASKING EFFECT OF OPIOID Amanda L.A. Mohr; Christophe P. ANTAGONISTS IN ACTIVITY-BASED Stove SCREENING TESTS 18740 Souleiman El Balkhi ; Roland Souleiman El Balkhi Clinical Toxicology/drugs of METABOLIC INTERACTIONS BETWEEN Lawson; Franck Saint-Marcoux abuse OXYCODONE, BENZODIAZEPINES OR DESIGNER BENZODIAZEPINES PLAY AN IMPORTANT ROLE IN OXYCODONE INTOXICATIONS 19050 Brenda de Winter F de Velde; MN Brenda de Winter Anti-infective drugs POPULATION PHARMACOKINETICS OF Neely; WM Yamada; BCP Koch; S IMIPENEM IN CRITICALLY ILL PATIENTS: A Harbarth; E von Dach; T van COMPARISON BETWEEN PARAMETRIC AND Gelder; A Huttner; JW Mouton NONPARAMETRIC METHODS September 23 13:30 - 14:45 ROOM 2 18941 Léonard De Vinci Kanda Kupa; Léonard de Vinci Kanda Anti-infective drugs ASSESSMENT OF MEROPENEM Camila Salinas Guillaux; Edvaldo Kupa PHARMACOKINETICS AT THE EARLIER Vieira de Campos; João Manoel da VERSUS LATE PERIOD SEPTIC SHOCK IN Silva Junior; Amanda Maria Ribas ADULT CRITICALLY BURN PATIENTS BASED Rosa de Oliveira; Elson Mendes ON DRUG SERUM MEASUREMENTS DONE Silva Junior; Gabriela Aparecida IN A REALtime Ferreira ; Thiago Camara Oliveira; Silvia Regina Cavani Jorge Santos; David de Souza Gomez September 23 19011 Jean-Baptiste FOULQUIER; Fabilen Florian Lemaitre Anti-infective drugs DEVELOPMENT OF A TOOL FOR OFLOXACIN FILY; Marie-Clémence VERDIER; AND LEVOFLOXACIN THERAPEUTIC DRUG 13:30 - 14:45 Matthieu REVEST; Camille TRON; MONITORING IN BONE AND JOINT ROOM 2 Cédric ARVIEUX; Antoine INFECTIONS PETITCOLLIN; Pierre TATTEVIN; Jean-LOUIS POLARD; Denis HUTEN; Eric Bellissant; Bruno LAVIOLLE; Florian LEMAITRE 19014 Paul Ken Leong Chin; Sharon Jane Paul Chin Anti-infective drugs VANCOMYCIN DOSING TARGETING Gardiner; Philip George Drennan; TROUGH CONCENTRATIONS LEADS TO Michael Maze; Michaela Beattie; UNNECESSARILY HIGH DRUG EXPOSURE Daniel Frank Broughton Wright; Stephen Chambers 19100 Miao Yan; Dan Tang; Bai-Li Song; Miao Yan Anti-infective drugs VORICONAZOL THERAPY OPTIMIZATION Min Zhang; Feng Wang; Da-Xiong BASED ON TOTAL BILIRUBIN IN PATIENTS Xiang WITH LIVER DYSFUNCTION 19047 Vikram Suryaprakash Gota; Murari Vikram Suryaprakash Gota TDM in Oncology PRETREATMENT TPMT ACTIVITY AND Gurjar; Hasmukh Jain; Manju ERYTHROCYTE 6-TGN LEVELS ARE Sengar PREDICTORS OF TOXICITY OF 6- MERCAPTOPURINE IN ACUTE LYMPHOBLASTIC LEUKEMIA September 23 13:30 - 14:45 ROOM 3 18907 Brenda Marisol Del Valle Monge; Brenda Marisol Del Valle TDM in Oncology COMPARISON OF TWO PHARMACOKINETIC Patricia Kleiner; Ulrich Jaehde Monge SOFTWARE TOOLS FOR THERAPEUTIC DRUG MONITORING OF FLUOROURACIL (5- FU) 18263 Lisa Stamp; Peter Chapman; Murray Barclay Pharmacogenetics RELATIONSHIPS BETWEEN ALLOPURINOL Murray Barclay; Anne Horne; Tony DOSE, OXYPURINOL LEVELS AND SERUM Merriman; Daniel Wright; Jill URATE Drake; Nicola Dalbeth 18928 Natalie Espinoza Giacomozzi; Natalie Espinoza Pharmacogenetics FREQUENCY OF THE CYP2C19*17 Carolina Salas Palma; Mauricio Giacomozzi POLYMORPHISM IN A CHILEAN Farfán Urzúa POPULATION AND ITS EFFECT ON September 23 VORICONAZOLE PLASMA CONCENTRATION 13:30 - 14:45 IN IMMUNOCOMPROMISED CHILDREN ROOM 3 18992 Nicolas Picard; Chantal Barin-Le Nicolas Picard Pharmacogenetics A CONSENSUAL PANEL FOR NEXT- Guellec; Séverine Cunat; Tiphaine GENERATION SEQUENCING IN De Beaumais; Alexandre Evrard; PHARMACOGENETICS FROM THE FRENCH Xavier Fonrose; Marie-Claude NATIONAL NETWORK OF Gagnieu; Elodie Gautier; Vincent PHARMACOGENETICS (RNPGX) Haufroid; Fabien Lamoureux; Litaty Mbatchi; Céline Narjoz; Léa Payen; Sylvie Quaranta; Fabienne Thomas; Céline Verstuyft; Marie- Anne Loriot; Jean-Christophe Boyer 18299 Lisa Stamp; Paula Keating; Paul Murray Barclay Other theme RELATIONSHIP BETWEEN ADALIMUMAB Hessian; Murray Barclay; John CONCENTRATIONS, ANTI-DRUG O'Donnell ANTIBODIES AND DISEASE ACTIVITY IN A CROSS SECTION OF RHEUMATOID ARTHRITIS PATIENTS.
Recommended publications
  • Anthem Blue Cross Drug Formulary
    Erythromycin/Sulfisoxazole (generic) INTRODUCTION Penicillins ...................................................................... Anthem Blue Cross uses a formulary Amoxicillin (generic) (preferred list of drugs) to help your doctor Amoxicillin/Clavulanate (generic/Augmentin make prescribing decisions. This list of drugs chew/XR) is updated quarterly, by a committee Ampicillin (generic) consisting of doctors and pharmacists, so that Dicloxacillin (generic) the list includes drugs that are safe and Penicillin (generic) effective in the treatment of diseases. If you Quinolones ..................................................................... have any questions about the accessibility of Ciprofloxacin/XR (generic) your medication, please call the phone number Levofloxacin (Levaquin) listed on the back of your Anthem Blue Cross Sulfonamides ................................................................ member identification card. Erythromycin/Sulfisoxazole (generic) In most cases, if your physician has Sulfamethoxazole/Trimethoprim (generic) determined that it is medically necessary for Sulfisoxazole (generic) you to receive a brand name drug or a drug Tetracyclines .................................................................. that is not on our list, your physician may Doxycycline hyclate (generic) indicate “Dispense as Written” or “Do Not Minocycline (generic) Substitute” on your prescription to ensure Tetracycline (generic) access to the medication through our network ANTIFUNGAL AGENTS (ORAL) _________________ of community
    [Show full text]
  • Critical Access COVID-19 Drugs Shortages (156-40)
    Resilient Drug Supply Project: Critical Acute Drug List & Critical COVID-19 Drug List Drug Shortages Reported by ASHP & FDA Shortages as of 8/22/2021 UMN RDSP UMN RDSP ASHP FDA Drug Critical Acute Drugs Drug Category List of 156 List of 40 Drug Drug # Generic Name Critical Acute Critical Shortage Shortage Drugs COVID-19 List List Drugs 1 Cisatracurium Paralytic X X Yes 2 Rocuronium Paralytic X X Yes 3 Vecuronium Paralytic X X Yes Yes 4 Succinylcholine Paralytic X X 5 Atracurium Paralytic X 6 Propofol Sedation X X Yes Yes 7 Midazolam Sedation X X Yes Yes 8 Lorazepam Sedation X X Yes Yes 9 Dexmedetomidine Sedation/Anesthesia X X Yes Yes 10 Phenobarbital Sedation X 11 Ketamine Sedation/Anesthesia X X Yes Yes 12 Diazepam Sedation X 13 Lidocaine Local Anesthetic X Yes Yes 14 Bupivacaine Local Anesthetic X Yes Yes 15 Fentanyl Pain X X Yes Yes 16 Hydromorphone Pain X X Yes Yes 17 Morphine Pain X X Yes Yes 18 Oxycodone Pain X X 19 Acetaminophen Pain & Fever X 20 Ketorolac Pain X Yes Yes 21 Anakinra Pain X 22 Oxygen Medical Gas X X 23 Nitric Oxide Medical Gas X 24 Sevoflurane Medical Gas X 25 Albuterol Bronchodilator X X Yes 26 Ipratropium (Inhaler) Bronchodilator X 27 Azithromycin Anti-infective X X 28 Piperacillin-Tazobactam Anti-infective X X 29 Cefepime Anti-infective X X Yes 30 Ceftriaxone Anti-infective X 31 Vancomycin Anti-infective X X Yes 32 Doxycycline Anti-infective X 33 Meropenem Anti-infective X X 34 Cefazolin Anti-infective X X Yes Yes 35 Levofloxacin Anti-infective X 36 Linezolid Anti-infective X 37 Ampicillin-Sulbactam Anti-infective
    [Show full text]
  • EAU-EANM-ESUR-ESTRO-SIOG Guidelines on Prostate Cancer 2019
    EAU - EANM - ESTRO - ESUR - SIOG Guidelines on Prostate Cancer N. Mottet (Chair), R.C.N. van den Bergh, E. Briers (Patient Representative), P. Cornford (Vice-chair), M. De Santis, S. Fanti, S. Gillessen, J. Grummet, A.M. Henry, T.B. Lam, M.D. Mason, T.H. van der Kwast, H.G. van der Poel, O. Rouvière, D. Tilki, T. Wiegel Guidelines Associates: T. Van den Broeck, M. Cumberbatch, N. Fossati, T. Gross, M. Lardas, M. Liew, L. Moris, I.G. Schoots, P-P.M. Willemse © European Association of Urology 2019 TABLE OF CONTENTS PAGE 1. INTRODUCTION 9 1.1 Aims and scope 9 1.2 Panel composition 9 1.2.1 Acknowledgement 9 1.3 Available publications 9 1.4 Publication history and summary of changes 9 1.4.1 Publication history 9 1.4.2 Summary of changes 9 2. METHODS 12 2.1 Data identification 12 2.2 Review 13 2.3 Future goals 13 3. EPIDEMIOLOGY AND AETIOLOGY 13 3.1 Epidemiology 13 3.2 Aetiology 14 3.2.1 Family history / genetics 14 3.2.2 Risk factors 14 3.2.2.1 Metabolic syndrome 14 3.2.2.1.1 Diabetes/metformin 14 3.2.2.1.2 Cholesterol/statins 14 3.2.2.1.3 Obesity 14 3.2.2.2 Dietary factors 14 3.2.2.3 Hormonally active medication 15 3.2.2.3.1 5-alpha-reductase inhibitors 15 3.2.2.3.2 Testosterone 15 3.2.2.4 Other potential risk factors 15 3.2.3 Summary of evidence and guidelines for epidemiology and aetiology 16 4.
    [Show full text]
  • TRACON Pharmaceuticals, Inc. IND 132664 5.3.3.2 Clinical Study
    TRACON Pharmaceuticals, Inc. IND 132664 5.3.3.2 Clinical Study Protocol 253PC101 Protocol Amendment #4 Dated 30May2019 IN CASE OF EMERGENCY Table 1: Emergency Contact Information Role in Study Name Address and Telephone number Primary Medical Monitor James Freddo, MD 4350 La Jolla Village Drive, Suite 800 San Diego, CA 92122 Mobile Phone: 1.858.472.2330 Facsimile: 1.858.550.0786 Email: [email protected] Secondary Medical Monitor Charles Theuer, MD, PhD 4350 La Jolla Village Drive, Suite 800 San Diego, CA 92122 Office: 1.858.550.0780 x233 Mobile Phone: 1.858.344.9400 Email: [email protected] Confidential Page 2 of 102 TRACON Pharmaceuticals, Inc. IND 132664 5.3.3.2 Clinical Study Protocol 253PC101 Protocol Amendment #4 Dated 30May2019 1. SYNOPSIS Name of Sponsor/Company: TRACON Pharmaceuticals, Inc. Name of Investigational Product: TRC253 Name of Active Ingredient: TRC253-HCl Title of Study: AN OPEN-LABEL PHASE 1/2A STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, PHARMACODYNAMICS, AND PRELIMINARY EFFICACY OF TRC253, AN ANDROGEN RECEPTOR ANTAGONIST, IN PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER Study center(s): 6 centers in Part 1, and approximately 20 centers in Part 2, in the United States Studied period: Phase of development: 1/2A Date first patient enrolled: May 2017 Date of determination of recommended phase 2 dose (RP2D): July 2018 Estimated date last patient enrolled: April 2021 Estimated date last patient completed: October 2021 Rationale: TRC253 is a high-affinity, small molecule antagonist of the androgen receptor (AR) with inhibitory activity against wild type AR and specific mutated variants of AR.
    [Show full text]
  • Here Is a Range of New Agents, Molecular Markers Ethics and Human Rights
    European Urology Today First Edition EUT Congress News 32nd33rd AnnualAnnual CongressCongress ofof thethe EuropeanEuropean AssociationAssociation ofof UrologyUrology Saturday, 2517 MarchMarch 20182017 Copenhagen,London, 24-2816-20 March 20182017 Meeting the challenges in urogenital diseases EU Health Commissioner Andriukaitis urges stronger collaboration By Joel Vega and Erika de Groot currently numbers 29 active units in 11 EU member Dr. Deepansh Dalela (US) received the Hans EAU Ernest Desnos Prize for his contributions to states. Marberger Award for the best European paper urological history, while Hashim Ahmed (GB) To the rhythmic, high energy beat of the published on minimally invasive surgery in was awarded the EAU Prostate Cancer Research synchronized, four-man Copenhagen Drummers Chapple also highlighted the crucial role of the EU in urology. Prof. Sergio Musitelli (IT) received the first Award. band, the 33rd Annual EAU Congress opened creating the ERNs which he said will lead to better data yesterday with European Commissioner for Health collection and mutual collaboration among European and Food Safety, Prof. Vytenis Andriukaitis (LT) scientists and clinical professionals. “To ensure the urging the audience to collaborate in the European sustainability of this project we need to form Reference Networks (ERNs). partnerships and work on common goals,” he said. “This flagship project reflects not only the need The Opening Ceremony traditionally highlights the to further strengthen our collaboration, but also EAU’s honorary members and awardees. Chapple the fact that we can and have achieved a lot if we conferred the title of Honorary Members to Gunnar put together our resources, knowledge and Aus (SE), Patrick Coloby (FR), Mani Menon (US) and commitment,” said Andriukaitis.
    [Show full text]
  • Fluoroquinolones-Associated Disability: It Is Not All in Your Head
    Review Fluoroquinolones-Associated Disability: It Is Not All in Your Head Maya Z. Freeman , Deanna N. Cannizzaro, Lydia F. Naughton and Cecilia Bove * Department of Biology, Bucknell University, Lewisburg, PA 17837, USA; [email protected] (M.Z.F.); [email protected] (D.N.C.); [email protected] (L.F.N.) * Correspondence: [email protected] Abstract: Fluoroquinolones (FQs) are a broad class of antibiotics typically prescribed for bacterial infections, including infections for which their use is discouraged. The FDA has proposed the existence of a permanent disability (Fluoroquinolone Associated Disability; FQAD), which is yet to be formally recognized. Previous studies suggest that FQs act as selective GABAA receptor inhibitors, preventing the binding of GABA in the central nervous system. GABA is a key regulator of the vagus nerve, involved in the control of gastrointestinal (GI) function. Indeed, GABA is released from the Nucleus of the Tractus Solitarius (NTS) to the Dorsal Motor Nucleus of the vagus (DMV) to tonically regulate vagal activity. The purpose of this review is to summarize the current knowledge on FQs in the context of the vagus nerve and examine how these drugs could lead to dysregulated signaling to the GI tract. Since there is sufficient evidence to suggest that GABA transmission is hindered by FQs, it is reasonable to postulate that the vagal circuit could be compromised at the NTS-DMV synapse after FQ use, possibly leading to the development of permanent GI disorders in FQAD. Keywords: fluoroquinolones; fluoroquinolones-associated-disability; vagus; gastrointestinal; digestion; DMV; NTS; FQAD Citation: Freeman, M.Z.; Cannizzaro, D.N.; Naughton, L.F.; Bove, C.
    [Show full text]
  • OCUFLOX (Ofloxacin Ophthalmic Solution) 0.3% Sterile
    ® OCUFLOX (ofloxacin ophthalmic solution) 0.3% sterile DESCRIPTION OCUFLOX® (ofloxacin ophthalmic solution) 0.3% is a sterile ophthalmic solution. It is a fluorinated carboxyquinolone anti-infective for topical ophthalmic use. Chemical Name: (±)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6- carboxylic acid. Contains: Active: ofloxacin 0.3% (3 mg/mL). Preservative: benzalkonium chloride (0.005%). Inactives: sodium chloride and purified water. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH. OCUFLOX® solution is unbuffered and formulated with a pH of 6.4 (range - 6.0 to 6.8). It has an osmolality of 300 mOsm/kg. Ofloxacin is a fluorinated 4-quinolone which differs from other fluorinated 4-quinolones in that there is a six member (pyridobenzoxazine) ring from positions 1 to 8 of the basic ring structure. CLINICAL PHARMACOLOGY Pharmacokinetics Serum, urine and tear concentrations of ofloxacin were measured in 30 healthy women at various time points during a ten-day course of treatment with OCUFLOX® solution. The mean serum ofloxacin concentration ranged from 0.4 ng/mL to 1.9 ng/mL. Maximum ofloxacin concentration increased from 1.1 ng/mL on day one to 1.9 ng/mL on day 11 after QID dosing for 10 1/2 days. Maximum serum ofloxacin concentrations after ten days of topical ophthalmic dosing were more than 1000 times lower than those reported after standard oral doses of ofloxacin. Tear ofloxacin concentrations ranged from 5.7 to 31 mcg/g during the 40 minute period following the last dose on day 11.
    [Show full text]
  • Penicillin Allergy Guidance Document
    Penicillin Allergy Guidance Document Key Points Background Careful evaluation of antibiotic allergy and prior tolerance history is essential to providing optimal treatment The true incidence of penicillin hypersensitivity amongst patients in the United States is less than 1% Alterations in antibiotic prescribing due to reported penicillin allergy has been shown to result in higher costs, increased risk of antibiotic resistance, and worse patient outcomes Cross-reactivity between truly penicillin allergic patients and later generation cephalosporins and/or carbapenems is rare Evaluation of Penicillin Allergy Obtain a detailed history of allergic reaction Classify the type and severity of the reaction paying particular attention to any IgE-mediated reactions (e.g., anaphylaxis, hives, angioedema, etc.) (Table 1) Evaluate prior tolerance of beta-lactam antibiotics utilizing patient interview or the electronic medical record Recommendations for Challenging Penicillin Allergic Patients See Figure 1 Follow-Up Document tolerance or intolerance in the patient’s allergy history Consider referring to allergy clinic for skin testing Created July 2017 by Macey Wolfe, PharmD; John Schoen, PharmD, BCPS; Scott Bergman, PharmD, BCPS; Sara May, MD; and Trevor Van Schooneveld, MD, FACP Disclaimer: This resource is intended for non-commercial educational and quality improvement purposes. Outside entities may utilize for these purposes, but must acknowledge the source. The guidance is intended to assist practitioners in managing a clinical situation but is not mandatory. The interprofessional group of authors have made considerable efforts to ensure the information upon which they are based is accurate and up to date. Any treatments have some inherent risk. Recommendations are meant to improve quality of patient care yet should not replace clinical judgment.
    [Show full text]
  • Subject Index to Abstracts
    003 1-3998/84/1804-429ASO2.00 PEDIATRIC RESEARCH Vol. 18 No. 4, 1984 Copyright 0 1984 International Pediatric Research Foundation, Inc. Prinled in U.S.A. Subject Index to Abstracts Abortion 767 Adenosine 2 15, 389 Aminoglycoside 342, 1140 Arachidonic acid 295, 925, 1125, Absorption, gastrointestinal 7 15 Adenosine deaminase deficiency Aminonucleoside nephrosis 1598 1 139, 1254 Absorption, passive 706 888 Aminophylline 137 1, 1853 Arginine 134 1 Abstinence 140 1 Adenosine triphosphate 839 Aminopyrine 388 Arginine vasopressin 234,235,249 Abuse 24, 28, 37, 105 Adenovirus 542, 1044, 1073, 1133 Ammonia 1 397, 1707 Argininosuccinicaciduria 78 1 Abuse, sexual 1085 Adenylate kinase 1648 Amnesia 825 Argininosuccinate 742, 1 166 Abuse, substance 62 Adipocytes 44 1 Amniotic fluid 229, 618, 779, Arrhythmia 179, 195, 222, 223, Acanthosis 12 17 Adipose tissue 23 1, 69 1 1304, 1535 377,857,9 13, 1796 Accidents 5 1 1, 5 18 Adiposity 673 Amniotic leak, prolonged 1739 Arteriohepatic dysplasia 1642 Accretion 300 Admissions 825 Amoxicillin 8 19 Artery 1753 Acetaldehyde 777 Adolescence 1, 3, 4, 9, 10, 12, 16, Amphotericin 900, 1350, 1369 Artery, carotid 20 1 Acetaminophen 282, 297, 38 1, 19, 22, 24, 25 Ampicillin 11 14, 1147 Artery, mesenteric 372 390 Adrenal 14, 315,405,413,446 Amrinone 175,345 Artery, pulmonary 186, 2 17, 328, Acetylcholine 277 Adrenal hormones 18 Androgen 14,449, 465, 12 17 5 10 Acetyl-CoA 1200 Adrenal medulla 270 Anemia 20, 140, 143, 500, 545, Arthritis 1 167 N-Acetyl-P-D-glucosaminidase Adrenarche 4 13, 502 816, 835, 846, 888, 896, 904,
    [Show full text]
  • PRIMAXIN (Imipenem and Cilastatin)
    • Known hypersensitivity to any component of PRIMAXIN (4) HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use ----------------------- WARNINGS AND PRECAUTIONS ----------------------­ PRIMAXIN safely and effectively. See full prescribing information • Hypersensitivity Reactions: Serious and occasionally fatal for PRIMAXIN. hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. If an allergic reaction PRIMAXIN® (imipenem and cilastatin) for Injection, for to PRIMAXIN occurs, discontinue the drug immediately (5.1). intravenous use • Seizure Potential: Seizures and other CNS adverse reactions, such Initial U.S. Approval: 1985 as confusional states and myoclonic activity, have been reported during treatment with PRIMAXIN. If focal tremors, myoclonus, or --------------------------- RECENT MAJOR CHANGES --------------------------­ seizures occur, patients should be evaluated neurologically, placed Indications and Usage (1.9) 12/2016 on anticonvulsant therapy if not already instituted, and the dosage of Dosage and Administration (2) 12/2016 PRIMAXIN re-examined to determine whether it should be decreased or the antibacterial drug discontinued (5.2). ----------------------------INDICATIONS AND USAGE ---------------------------­ • Increased Seizure Potential Due to Interaction with Valproic Acid: PRIMAXIN for intravenous use is a combination of imipenem, a penem Co-administration of PRIMAXIN, to patients receiving valproic acid antibacterial, and cilastatin, a renal dehydropeptidase inhibitor, or divalproex sodium results in a reduction in valproic acid indicated for the treatment of the following serious infections caused by concentrations. The valproic acid concentrations may drop below designated susceptible bacteria: the therapeutic range as a result of this interaction, therefore • Lower respiratory tract infections. (1.1) increasing the risk of breakthrough seizures. The concomitant use of • Urinary tract infections.
    [Show full text]
  • Swedres-Svarm 2019
    2019 SWEDRES|SVARM Sales of antibiotics and occurrence of antibiotic resistance in Sweden 2 SWEDRES |SVARM 2019 A report on Swedish Antibiotic Sales and Resistance in Human Medicine (Swedres) and Swedish Veterinary Antibiotic Resistance Monitoring (Svarm) Published by: Public Health Agency of Sweden and National Veterinary Institute Editors: Olov Aspevall and Vendela Wiener, Public Health Agency of Sweden Oskar Nilsson and Märit Pringle, National Veterinary Institute Addresses: The Public Health Agency of Sweden Solna. SE-171 82 Solna, Sweden Östersund. Box 505, SE-831 26 Östersund, Sweden Phone: +46 (0) 10 205 20 00 Fax: +46 (0) 8 32 83 30 E-mail: [email protected] www.folkhalsomyndigheten.se National Veterinary Institute SE-751 89 Uppsala, Sweden Phone: +46 (0) 18 67 40 00 Fax: +46 (0) 18 30 91 62 E-mail: [email protected] www.sva.se Text, tables and figures may be cited and reprinted only with reference to this report. Images, photographs and illustrations are protected by copyright. Suggested citation: Swedres-Svarm 2019. Sales of antibiotics and occurrence of resistance in Sweden. Solna/Uppsala ISSN1650-6332 ISSN 1650-6332 Article no. 19088 This title and previous Swedres and Svarm reports are available for downloading at www.folkhalsomyndigheten.se/ Scan the QR code to open Swedres-Svarm 2019 as a pdf in publicerat-material/ or at www.sva.se/swedres-svarm/ your mobile device, for reading and sharing. Use the camera in you’re mobile device or download a free Layout: Dsign Grafisk Form, Helen Eriksson AB QR code reader such as i-nigma in the App Store for Apple Print: Taberg Media Group, Taberg 2020 devices or in Google Play.
    [Show full text]
  • Penetration of 0.3% Ciprofloxacin, 0.3% Ofloxacin, and 0.5
    Brazilian Journal of Medical and Biological Research (2017) 50(7): e5901, http://dx.doi.org/10.1590/1414-431X20175901 ISSN 1414-431X 1/6 Penetration of 0.3% ciprofloxacin, 0.3% ofloxacin, and 0.5% moxifloxacin into the cornea and aqueous humor of enucleated human eyes G.C.M. Silva1, V.A.P. Jabor2, P.S. Bonato2, E.Z. Martinez3 and S.J. Faria-e-Sousa1 1Departamento de Oftalmologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil 2Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil 3Departamento de Medicina Social, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil Abstract We aimed to quantify the penetration of ciprofloxacin, ofloxacin, and moxifloxacin into the cornea and aqueous humor of cadaver eyes. A total of 60 enucleated eyes, not eligible for corneal transplantation, were divided into three groups and immersed in commercial solutions of 0.3% ciprofloxacin, 0.3% ofloxacin, or 0.5% moxifloxacin for 10 min. Whole corneas and samples of aqueous humor were then harvested and frozen, and drug concentrations analyzed by liquid chromatography tandem mass spectrometry. The mean corneal concentration of moxifloxacin was twice as high as ofloxacin, and the latter was twice as high as ciprofloxacin. The mean concentration of moxifloxacin in the aqueous humor was four times higher than the other antibiotics, and the mean concentrations of ciprofloxacin and ofloxacin were statistically similar. The amount of drug that penetrated the anterior chamber after a 10-min immersion was far below the safe limit of endothelial toxicity of each preparation.
    [Show full text]