Author Manuscript Published OnlineFirst on April 17, 2018; DOI: 10.1158/1078-0432.CCR-18-0123 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. A Gallium-67/68-labeled antibody fragment for immuno-SPECT/PET shows low renal radioactivity without loss of tumor uptake Authors: Tomoya Uehara1*, Miki Yokoyama1, Hiroyuki Suzuki1, Hirofumi Hanaoka2, Yasushi Arano1. Affiliations: 1 Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675 Japan. 2 Graduate School of Medicine, Gunma University, 3-39-15 Showa-chou, Maebashi, 371-8511 Japan. Running title: 67/68Ga-labeled Fab of low renal radioactivity levels Keywords: gallium-67/68, renal radioactivity, antibody fragment, renal brush border enzymes, immunoPET/SPECT. *To whom correspondence should be addressed: Tomoya Uehara Ph.D. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675 Japan. TEL: +81-43-226-2898 E-mail:
[email protected] 1 Downloaded from clincancerres.aacrjournals.org on September 24, 2021. © 2018 American Association for Cancer Research. Author Manuscript Published OnlineFirst on April 17, 2018; DOI: 10.1158/1078-0432.CCR-18-0123 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. The word count: 5511 The total number of figure and tables: 4 The authors declare no potential conflicts of interest. 2 Downloaded from clincancerres.aacrjournals.org on September 24, 2021. © 2018 American Association for Cancer Research. Author Manuscript Published OnlineFirst on April 17, 2018; DOI: 10.1158/1078-0432.CCR-18-0123 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.