Journal of Clinical Medicine Review The Role of MET Inhibitor Therapies in the Treatment of Advanced Non-Small Cell Lung Cancer Ramon Andrade De Mello 1,2,3,* , Nathália Moisés Neves 2 , Giovanna Araújo Amaral 2, Estela Gudin Lippo 4, Pedro Castelo-Branco 1, Daniel Humberto Pozza 5 , Carla Chizuru Tajima 6 and Georgios Antoniou 7 1 Algarve Biomedical Centre, Department of Biomedical Sciences and Medicine University of Algarve (DCBM UALG), 8005-139 Faro, Portugal;
[email protected] 2 Division of Medical Oncology, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo 04037-004, Brazil;
[email protected] (N.M.N.);
[email protected] (G.A.A.) 3 Precision Oncology and Health Economics Group (ONCOPRECH), Post-Graduation Program in Medicine, Nine of July University (UNINOVE), São Paulo 01525-000, Brazil 4 School of Biomedical Sciences, Santo Amaro University, São Paulo 01525-000, Brazil;
[email protected] 5 Department of Biomedicine & I3S, Faculty of Medicine, University of Porto (FMUP), 4200-317 Porto, Portugal;
[email protected] 6 Hospital São José & Hospital São Joaquim, A Beneficência Portuguesa de São Paulo, São Paulo 01323-001, Brazil;
[email protected] 7 Division of Medical Oncology, Mount Vernon Cancer Center, London HA6 2RN, UK;
[email protected] * Correspondence:
[email protected] Received: 15 May 2020; Accepted: 10 June 2020; Published: 19 June 2020 Abstract: Introduction: Non-small cell lung cancer (NSCLC) is the second most common cancer globally. The mesenchymal-epithelial transition (MET) proto-oncogene can be targeted in NSCLC patients. Methods: We performed a literature search on PubMed in December 2019 for studies on MET inhibitors and NSCLC.