A Systematic Review and Meta-Analysis Comparing The
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TV Channel Distribution in Europe: Table of Contents
TV Channel Distribution in Europe: Table of Contents This report covers 238 international channels/networks across 152 major operators in 34 EMEA countries. From the total, 67 channels (28%) transmit in high definition (HD). The report shows the reader which international channels are carried by which operator – and which tier or package the channel appears on. The report allows for easy comparison between operators, revealing the gaps and showing the different tiers on different operators that a channel appears on. Published in September 2012, this 168-page electronically-delivered report comes in two parts: A 128-page PDF giving an executive summary, comparison tables and country-by-country detail. A 40-page excel workbook allowing you to manipulate the data between countries and by channel. Countries and operators covered: Country Operator Albania Digitalb DTT; Digitalb Satellite; Tring TV DTT; Tring TV Satellite Austria A1/Telekom Austria; Austriasat; Liwest; Salzburg; UPC; Sky Belgium Belgacom; Numericable; Telenet; VOO; Telesat; TV Vlaanderen Bulgaria Blizoo; Bulsatcom; Satellite BG; Vivacom Croatia Bnet Cable; Bnet Satellite Total TV; Digi TV; Max TV/T-HT Czech Rep CS Link; Digi TV; freeSAT (formerly UPC Direct); O2; Skylink; UPC Cable Denmark Boxer; Canal Digital; Stofa; TDC; Viasat; You See Estonia Elion nutitv; Starman; ZUUMtv; Viasat Finland Canal Digital; DNA Welho; Elisa; Plus TV; Sonera; Viasat Satellite France Bouygues Telecom; CanalSat; Numericable; Orange DSL & fiber; SFR; TNT Sat Germany Deutsche Telekom; HD+; Kabel -
William H. Gordon Associates
976 1986 OUR FIRST DECADE 1976 William H. Gordon Associates (WHGA) is founded as a civil Jimmy Carter is elected President engineering firm by William “Hank” Gordon with 2 employees The first 4.6 miles of the Washington Metro Subway system opens First office opens at 11480 Sunset Hills Road in Reston, VA U.S. celebrates its bicentennial WHGA is awarded its first project providing engineering services for Gallows Estates (Residential subdivision) The world’s first VCR is released 1977 OUNTY FIRST C ITS Hank Gordon purchases first company cell phone for $2500 Elvis Presley dies in Memphis, TN THE ON TO WHGA holds its first company picnic at Algonkian Regional Park U.S. Department of Energy is created NOTABLE PROJECTS Tysons Corner Marriott (Fairfax County, VA) APPROVED Lake Fairfax Business Park (Fairfax County, VA) SUBMISSION Jefferson District Park (Fairfax County, VA) NASA shuttle makes its first test flight on back of jet liner 1978 Polish Cardinal Karol Wojtyla elected Pope Saint John Paul II WHGA is officially incorporated Louise Joy Brown becomes first human born by in vitro fertilization NOTABLE PROJECTS Pohick Estates Park (Fairfax County, VA) The first legal casino in the eastern U.S. opens in Atlantic City, NJ St. Bernadette’s Church (Fairfax County, VA) Bowman Green (Reston, VA) Double Eagle II becomes the first hot air balloon to cross the Atlantic Ocean (137 hour flight) 1979 U.S. Embassy in Iran is stormed by Iranian students, beginning the Iranian hostage crisis WHGA purchases its first computer ESPN, America’s first 24-hour sports network, airs NOTABLE PROJECTS National Business Education Association (Reston, VA) Mother Teresa is awarded the Nobel Peace Prize for work undertaken in the struggle to overcome poverty & distress in India CIA Reston Office China implements the “One Child Policy” after registering as the first country with a population of 1 billion 1980 Ronald Reagan is elected President Work begins on Woodland Park as an industrial office park Mount St. -
MAINE PROJECTED STARTERS 12/10 MAINE-MACHIAS ESPN+ 7:00 P.M
RYAN LONG - MAINE MEN’S BASKETBALL CONTACT November 6, 2018 - Vs. Denver - game notes OFFICE: (207) 581-4849 | CELL: (570) 332-3078 | [email protected] @Blackbearsmbb #BlackBearNation SCHEDULE/RESULTS Maine TALE OF THE TAPE denver DATE OPPONENT TV TIME/RES. 0-0/0-0 record/conf. 0-0/0-0 11/1 MAINE-PRESQUE ISLE& -- W, 82-40 66.9 points per game 73.1 75.2 opponent points per game 73.0 11/6 @ Denver Pioneers All-Access 9:00 p.m. -8.3 scoring margin +0.1 11/8 @ Utah Pac-12 Network 9:00 p.m. .408 field goal percentage .473 11/10 @ San Francisco TBD 5:00 p.m. .302 3-point field goal percentage .400 .689 free throw percentage .694 11/17 @ NC State ^ ACC Network Extra 2:00 p.m. -3.4 rebounds per game 36.9 11/20 @ North Texas ^ C-USA.TV 8:00 p.m. 35.3 REBOUND MARGIN +6.0 11/25 @ Quinnipiac ESPN+ 2:00 p.m. 11.8 ASSISTS PER GAME 15.1 15.5 TURNOVERS PER GAME 15.0 11/28 PRINCETON ^ ESPN+ 7:00 p.m. 2.9 BLOCKS PER GAME 2.4 12/1 @ Saint Peter’s ^ Peacocks All-Acess 3:00 p.m. 6.4 STEALS PER GAME 4.3 12/4 FORDHAM ESPN 3 7:00 p.m. 12/8 @ Dartmouth ESPN+ 2:00 p.m. HOW TO FOLLOW MAINE PROJECTED STARTERS 12/10 MAINE-MACHIAS ESPN+ 7:00 p.m. 12/16 @ Duquesne ESPN+ Noon G SERGIO EL DARWICH 12/22 CENTRAL CONN. -
Challenging ESPN: How Fox Sports Can Play in ESPN's Arena
Challenging ESPN: How Fox Sports can play in ESPN’s Arena Kristopher M. Gundersen May 1, 2014 Professor Richard Linowes – Kogod School of Business University Honors Spring 2014 Gundersen 1 Abstract The purpose of this study is to explore the relationship ESPN has with the sports broadcasting industry. The study focuses on future prospects for the industry in relation to ESPN and its most prominent rival Fox Sports. It introduces significant players in the market aside from ESPN and Fox Sports and goes on to analyze the current industry conditions in the United States and abroad. To explore the future conditions for the market, the main method used was a SWOT analysis juxtaposing ESPN and Fox Sports. Ultimately, the study found that ESPN is primed to maintain its monopoly on the market for many years to come but Fox Sports is positioned well to compete with the industry behemoth down the road. In order to position itself alongside ESPN as a sports broadcasting power, Fox Sports needs to adjust its time horizon, improve its bids for broadcast rights, focus on the personalities of its shows, and partner with current popular athletes. Additionally, because Fox Sports has such a strong regional persona and presence outside of sports, it should leverage the relationship it has with those viewers to power its national network. Gundersen 2 Introduction The world of sports is a fast-paced and exciting one that attracts fanatics from all over. They are attracted to specific sports as a whole, teams within a sport, and traditions that go along with each sport. -
Full Text of the Decision Regarding the Anticipated
Anticipated acquisition by British Telecommunications plc of ESPN Global Limited ME/6004/13 The OFT’s decision on reference under section 33(1) given on 5 July 2013. Full text of decision published 18 July 2013. Please note that the square brackets indicate figures or text which have been deleted or replaced in ranges at the request of the parties or third parties for reasons of commercial confidentiality. PARTIES 1. British Telecommunications plc (BT) is an international provider of telecommunications solutions and IT services in the UK and worldwide. BT’s UK turnover for the financial year ending March 2012 was £14.9 billion. 2. ESPN Global Limited (ESPN) is a private limited company limited by shares incorporated under the laws of the Republic of Ireland. ESPN is wholly owned by ESPN, Inc. ESPN broadcasts channels dedicated to sports coverage. At the time of the transaction ESPN operated three sports channels in the UK, namely ESPN, ESPN America and ESPN classic. ESPN’s UK turnover for the financial year ending 30 September 2012 was £131 million. TRANSACTION 3. The parties signed a Share Purchase Agreement on 25 February 2013. The transaction is due to complete on or around 31 July 2013. BT is due to pay a consideration of [ ] million, with adjustments, for the entire issued share capital of ESPN. The assets being transferred include the rights and content associated with two of ESPN’s channels (namely ESPN and ESPN America), but not the third channel (namely ESPN Classic).1 1 ESPN classic is planned to cease to broadcast before completion of the transaction. -
Daiichi Sankyo Group Value Report 2019
External Evaluations (as of June 30,2019) ™ Daiichi Sankyo Group Value Report 2019 Value Daiichi Sankyo Group MSCI Japan Empowering Women Select Index THE INCLUSION OF DAIICHI SANKYO CO.,LTD. IN ANY MSCI INDEX, AND THE USE OF MSCI LOGOS, TRADEMARKS, SERVICE MARKS OR INDEX NAMES HEREIN, DO NOT CONSTITUTE A SPONSORSHIP, ENDORSEMENT OR PROMOTION OF DAIICHI SANKYO CO.,LTD. BY MSCI OR ANY OF ITS AFFILIATES. THE MSCI INDEXES ARE THE EXCLUSIVE PROPERTY OF MSCI. MSCI AND THE MSCI INDEX NAMES AND LOGOS ARE TRADE- MARKS OR SERVICE MARKS OF MSCI OR ITS AFFILIATES. “Eruboshi” Certification Mark “Kurumin” Certification Mark Logo given to Certified Health and Productivity Management Organization (White500) This report uses FSC® certified paper, which indicates that the paper used to print this Paper report was produced from properly managed forests. 3-5-1, Nihonbashi-honcho, Chuo-ku, Tokyo 103-8426, Japan This report was printed using 100% Inks biodegradable printing inks from vegetable Corporate Communications Department oil. Daiichi Sankyo Group Tel: +81-3-6225-1126 CSR Department The waterless printing method used for this Value Report 2019 Tel: +81-3-6225-1067 Printing report minimized the use and release of harmful liquid wastes. https://www.daiichisankyo.com/ Printed in Japan 005_7045687911909.indd 1 2019/09/27 18:22:19 Introduction Our Mission The Core Values and Commitments serve as the criteria for business activities and In addition, we have established the DAIICHI SANKYO Group Corporate Conduct Charter . decision-making used by executive officers and employees in working to fulfill Our Mission . This charter calls on us to fulfill our social responsibilities by acting with the highest ethical Our Corporate Slogan succinctly explains the spirit of Our Mission, Core Values and standards and a good social conscience appropriate for a company engaged in business Commitments. -
Targeted Therapies in Melanoma: Knowledge, Resistance And
ooggeenneessii iinn ss && rrcc aa MM CC uu tt ff aa Journal ofJournal of oo gg ll ee ee aa aa nn nn nn nn ee ee rr rr ss ss uu uu ii ii Colombino et al., J Carcinog Mutagen 2014, S4:S4 ss ss oo oo JJ JJ ISSN: 2157-2518 CarCarcinogenesiscinogenesis & Mutagenesis DOI: 10.4172/2157-2518.S4-004 Review Article Open Access Targeted Therapies in Melanoma: Knowledge, Resistance and Perspectives Maria Colombino1*, Maria Cristina Sini1, Amelia Lissia2, Antonio Cossu2, and Giuseppe Palmieri1 1Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Italy 2University Hospital Health Unit - Azienda Ospedaliero Universitaria (AOU), Via Matteotti, 07100 Sassari, Italy *Corresponding author: Dr. Maria Colombino, Unit of Cancer Genetics, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Traversa La Crucca, 3 - Baldinca Li Punti, 07100 Sassari, Italy, Tel. +39 079 2841239; Fax +39 079 2841299; E-mail: [email protected] Received date: Mar 18, 2014, Accepted date: May 25, 2014, Published date: May 31, 2014 Copyright: © 2014 Colombino M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Several molecular mechanisms appear to play a major role in melanoma genesis and progression. Current targeted therapies focus on contrasting the activation of RAS/RAF/MEK/ERK and, to a less extent, PI3K/AKT pathways. Development of inhibitors of key effectors (mainly, BRAF mutant and MEK) has significantly improved treatment of patients with advanced melanoma. -
Novel Drug Candidates for Blast Phase Chronic Myeloid Leukemia from High-Throughput Drug Sensitivity and Resistance Testing
OPEN Citation: Blood Cancer Journal (2015) 5, e309; doi:10.1038/bcj.2015.30 www.nature.com/bcj ORIGINAL ARTICLE Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing PO Pietarinen1, T Pemovska2, M Kontro1, B Yadav2, JP Mpindi2, EI Andersson1, MM Majumder2, H Kuusanmäki2, P Koskenvesa1, O Kallioniemi2, K Wennerberg2, CA Heckman2, S Mustjoki1,3 and K Porkka1,3 Chronic myeloid leukemia in blast crisis (CML BC) remains a challenging disease to treat despite the introduction and advances in tyrosine kinase inhibitor (TKI) therapy. In this study we set out to identify novel candidate drugs for CML BC by using an unbiased high-throughput drug testing platform. We used three CML cell lines representing different types of CML blast phases (K562, EM-2 and MOLM-1) and primary leukemic cells from three CML BC patients. Profiling of drug responses was performed with a drug sensitivity and resistance testing platform comprising 295 anticancer agents. Overall, drug sensitivity scores and the drug response profiles of cell line and primary cell samples correlated well and were distinct from other types of leukemia samples. The cell lines were highly sensitive to TKIs and the clinically TKI-resistant patient samples were also resistant ex vivo. Comparison of cell line and patient sample data identified new candidate drugs for CML BC, such as vascular endothelial growth factor receptor and nicotinamide phosphoribosyltransferase inhibitors. Our results indicate that these drugs in particular warrant further evaluation by analyzing a larger set of primary patient samples. The results also pave way for designing rational combination therapies. -
Tivozanib for Advanced Renal Cell Carcinoma – First Line January 2011
Tivozanib for advanced renal cell carcinoma – first line January 2011 This technology summary is based on information available at the time of research and a limited literature search. It is not intended to be a definitive statement on the safety, efficacy or effectiveness of the health technology covered and should not be used for commercial purposes. The National Horizon Scanning Centre Research Programme is part of the National Institute for Health Research January 2011 Tivozanib for advanced renal cell carcinoma – first line Target group • Renal cell carcinoma (RCC): advanced – first line. Technology description Tivozanib (AV-951; KRN-951) is a selective inhibitor of vascular endothelial growth factor (VEGF) receptors 1, 2 and 3, which are involved in angiogenesis. Inhibition of VEGF driven angiogenesis has been demonstrated to reduce vascularisation of tumours, thereby suppressing tumour growth. Tivozanib is intended to substitute current therapies for the first line treatment of patients with advanced RCC. It is administered orally at 1.5mg once daily for 3 weeks in a 4 week cycle. Tivozanib is in phase I/II clinical trials for the treatment of breast cancer, gastrointestinal cancer and non-small cell lung cancer. Innovation and/or advantages If licensed, tivozanib will offer an additional first line treatment option for advanced RCC, a condition where current therapies offer relatively limited benefit. Developer AVEO Pharma Limited. Availability, launch or marketing dates, and licensing plans In phase III clinical trials. NHS or Government priority area This topic is relevant to the NHS Cancer Plan (2000) and Cancer Reform Strategy (2007). Relevant guidance • NICE technology appraisal in development. -
A Phase I Dose Escalation Study of Tivantinib (ARQ 197) in Adult
Author Manuscript Published OnlineFirst on October 5, 2011; DOI: 10.1158/1078-0432.CCR-11-1002 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. A Phase I Dose Escalation Study of Tivantinib (ARQ 197) in Adult Patients with Metastatic Solid Tumors Lee S. Rosen,1* Neil Senzer,2 Tarek Mekhail,3 Ram Ganapathi,3 Feng Chai,4 Ronald E Savage,4 Carol Waghorne,4 Giovanni Abbadessa,4 Brian Schwartz,4 Robert Dreicer3 1Premiere Oncology, 2020 Santa Monica Boulevard, Suite 600, Santa Monica, CA 90404. 2Mary Crowley Cancer Research Centers, 1700 Pacific St, Suite 1100, Dallas, TX 75201. 3 Department of Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue R35, Cleveland, OH 44195. Dr. Mekhail is now with Florida Hospital Cancer Institute, 2501 North Orange Avenue, Orlando FL 32804. 4ArQule, Inc., Woburn, MA. *Corresponding author: Lee Rosen Tel: (310) 633-8400 Fax: (310) 633-8419 E-mail: [email protected] Running Title: Phase I Trial of Tivantinib in Patients with Metastatic Solid Tumors Key words: tivantinib, ARQ 197, pharmacokinetics, phase I, safety Word count: 3657 (not including Abstract and references) 41 references 5 tables and 1 figure 1 Downloaded from clincancerres.aacrjournals.org on September 23, 2021. © 2011 American Association for Cancer Research. Author Manuscript Published OnlineFirst on October 5, 2011; DOI: 10.1158/1078-0432.CCR-11-1002 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Translational Relevance Inhibitors of the receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), have demonstrated activity in select cancer types. -
Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia
Published OnlineFirst September 20, 2013; DOI: 10.1158/2159-8290.CD-13-0350 RESEARCH ARTICLE Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia Tea Pemovska 1 , Mika Kontro 2 , Bhagwan Yadav 1 , Henrik Edgren 1 , Samuli Eldfors1 , Agnieszka Szwajda 1 , Henrikki Almusa 1 , Maxim M. Bespalov 1 , Pekka Ellonen 1 , Erkki Elonen 2 , Bjørn T. Gjertsen5 , 6 , Riikka Karjalainen 1 , Evgeny Kulesskiy 1 , Sonja Lagström 1 , Anna Lehto 1 , Maija Lepistö1 , Tuija Lundán 3 , Muntasir Mamun Majumder 1 , Jesus M. Lopez Marti 1 , Pirkko Mattila 1 , Astrid Murumägi 1 , Satu Mustjoki 2 , Aino Palva 1 , Alun Parsons 1 , Tero Pirttinen 4 , Maria E. Rämet 4 , Minna Suvela 1 , Laura Turunen 1 , Imre Västrik 1 , Maija Wolf 1 , Jonathan Knowles 1 , Tero Aittokallio 1 , Caroline A. Heckman 1 , Kimmo Porkka 2 , Olli Kallioniemi 1 , and Krister Wennerberg 1 ABSTRACT We present an individualized systems medicine (ISM) approach to optimize cancer drug therapies one patient at a time. ISM is based on (i) molecular profi ling and ex vivo drug sensitivity and resistance testing (DSRT) of patients’ cancer cells to 187 oncology drugs, (ii) clinical implementation of therapies predicted to be effective, and (iii) studying consecutive samples from the treated patients to understand the basis of resistance. Here, application of ISM to 28 samples from patients with acute myeloid leukemia (AML) uncovered fi ve major taxonomic drug-response sub- types based on DSRT profi les, some with distinct genomic features (e.g., MLL gene fusions in subgroup IV and FLT3 -ITD mutations in subgroup V). Therapy based on DSRT resulted in several clinical responses. -
VEGF) Inhibitors
Understanding and managing toxicities of vascular endothelial growth factor (VEGF) inhibitors Manuela Schmidinger * Medical University of Vienna, Vienna, Austria 1. Introduction than bevacizumab. Interestingly, the newest VEGFR–tyrosine kinase inhibitor (TKI) tivozanib appears to have little effect Vascular-endothelial growth-factor (receptor) (VEGF)(R)-inhib- on fatigue levels (all grades: up to 18%, grade P3: 5%). iting agents – sunitinib [1–3], sorafenib [4,5], pazopanib [2,6], Gastrointestinal side-effects are extremely common in pa- bevacizumab [7,8], axitinib [5] and tivozanib [9,10] –have tients on VEGFR–TKI treatment. In particular, sunitinib and changed the therapeutic landscape in metastatic renal-cell axitinib were shown to cause reduced appetite and/or anorex- carcinoma (mRCC). Five out of six agents have been approved ia in up to 34% of the patients. In the case of sunitinib, this for either first-line (sunitinib, pazopanib and bev- may be caused partly by the high incidence of stomatitis acizumab + interferon-alpha) or second-line (sorafenib, axiti- and/or dysgeusia (30% and 46%, respectively). Diarrhoea is an- nib) treatment of metastatic or advanced RCC. With these other frequent gastrointestinal toxicity: high incidences of all novel strategies, the median overall survival of patients has grades of diarrhoea were reported from patients on sunitinib increased considerably, often, however, at the expense of (61%), sorafenib (53%), pazopanib (63%) and axitinib 55%, chronic side-effects. Common treatment-related side-effects again with quite a favourable profile for tivozanib (22%). include: (1) general symptoms such as fatigue and asthenia, The most common skin toxicities caused by VEGFR inhib- (2) gastrointestinal symptoms such as diarrhoea and stomati- itors are hand–foot syndrome (HFS), skin- and/or hair-depig- tis, (3) skin toxicities, (4) cardiovascular toxicities and (5) a mentation and rash.