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Fraunhofer IME Annual Report 2019

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Fraunhofer IME Annual Report 2019 FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME Years ANNUAL REPORT 2019 60 YEARS OF RESEARCH FOR TODAY, TO- MORROW AND THE DAY AFTER TOMORROW Welcome The Institute Our Research In Dialog In Focus Selected P e o p l e a n d E v e n t s Facts 2019 Publications E d i t o r i a l n o t e s 4 | 5 6 | 27 28 | 41 42 | 47 48 | 53 54 | 61 62 | 73 74 | 116 60 years of history The radiokitchen – Quo Biological plant protection: Understanding flower Plant cell packs named Brief reports Publications vadis, molecule? With microbes against development - Targeted cookies Employees, meetings, Fraunhofer IME profile insect pests increase of plant biomass! suc cesses and new per- Patents Colorful potato PD Dr. Gundula Noll Characterization of spectives at Fraunhofer IME Fraunhofer IME within the An interview with protein interactions in Bachelor’s, Master’s, Fraunhofer-Gesellschaft Translation of research Dr. Kwang-Zin Lee living cells State Examination into medical applications and Doctoral Theses Advisory Board Deciphering the mecha- Insect virulence inhibitors nisms of rubber biosyn- Networks in science Business fields/areas for the therapy of lung thesis in dandelions and industry Molecular Biotechnology, infections Applied Ecology and Bio- Impact of insect meal on Photo acknowledgments resources, Recycling CO2 emissions fat metabolism Translational Medicine with bacteria Editorial notes Novel insights into the Institute management and Using artificial intelligence mechanism of caspase-6 locations to predict biological age Bioconcentration studies Institute data with the crustacean Hyalella azteca 60 YEARS: TEMPORA MUTANTUR, NOS ET MUTAMUR IN ILLIS 70 years of the Fraunhofer-Gesellschaft, 60 years of Fraunhofer at Schmallenberg, two digitization for sustainable (bio)production. A further highlight is the market launch of a bicycle good reasons to celebrate. On December 1, 1959, the Fraunhofer-Gesellschaft integrated tire made from latex of the Russian dandelion - the optimization of the plant and the process the research laboratory founded two years earlier by Dr. Karl Bisa in Schmallenberg into the for extracting the valuable material were established at Fraunhofer IME in Münster. Fraunhofer Institute for Aerobiology IAe. In cooperation with other Fraunhofer Institutes, the Translational Medicine division located in In 2019, the division “Applied Ecology and Bioresources” celebrated the 60th anniversary Frankfurt am Main and Hamburg fosters medical progress through transdisciplinary cutting- of the founding of the Fraunhofer site Schmallenberg. Initially with a focus on inhalation edge research. The so-called 4D concept plays a significant role in this regard. In order to toxicology, it can be regarded as the origin of Fraunhofer health research. As the Institute for optimally address the 4D (“Drugs”, “Diagnostics”, “Data”, “Devices”) to the benefit of the toxicology and aerosol research ITA moved to Hannover in 1985 (today Fraunhofer ITEM), patient, experts from various scientific disciplines (physicians, natural scientists, computer in Schmallenberg environmental risk assessment of substances became the dominant issue scientists, engineers) need to work together. Based on the diversity of its constituent institutes, (Institute for Environmental Chemistry and Ecotoxicology IUCT). Today, the branch of Applied Fraunhofer is the only research organization that, is able to optimally apply all 4D in health Ecology holds a leading position in Europe regarding research for and development of research and thus constitutes the ideal partner for innovative development projects. Artificial substance-related test methods (OECD, EU, DIN/ISO), test strategies and evaluation concepts intelligence and machine learning methods are increasingly being employed, for example, in for environmental risk and consumer exposure assessment. It is acknowledged as scientific the development of a digital twin in the Fraunhofer lighthouse project MED²ICIN together mediator between regulatory authorities and industry. Our success is reflected by the steady with an algorithm for testing biological age. In the course of expansion of a biobank, a growth in business volume and staff. Both were doubled in the last 11 years at routinely high strategic cooperation in the field of spondyloarthritides has been established with the German industry yields of more than 50 percent, triggering the current construction of new laboratory Rheumatism Research Center Berlin. Fraunhofer IME is also the strategic research partner of a capacities and meeting rooms. US biotech company for the development of a drug for a rare disease. Our efforts to establish The branch Bioresources, funded by the LOEWE programme in Gießen, developed to become an inflammation clinic as an integrative concept for the effective treatment of immune- the leading research centre for insect biotechnology and will move into its new building in mediated diseases is of major importance. The aim is to connect excellent transdisciplinary 2020. A core business is the valorization of biodiversity as a resource for the bioeconomy. research with interdisciplinary care, in an innovative and cost intelligent way, for the well-being Example platforms are the microbial strain collection taken over from Sanofi and a library of of patients and to contribute to the development of sustainable healthcare in Germany. animal toxins. The division Bioresources develops innovative technologies for the sustainable control of detrimental and vector insects, for the industrial use of insects (insect farming) and Finally, we wish to thank all those who, through their continued commitment and support, the conservation of biodiversity. have contributed to our success in 2019. We are most grateful to our business and research partners for their excellent and dependable cooperation, and to our staff for their dedication. The “Molecular Biotechnology“ division was established 20 years ago and has further We wish everyone involved an equally successful year in 2020, stay healthy! expanded its activities in white and green biotechnology. Together with industrial partners, a number of bio-economic processes and products have been transferred to commercial Frankfurt am Main, Schmallenberg and Aachen in March 2020 application, such as plant stem cells for the cosmetics industry, a cell-free expression system, an amylose-free potato variety and tires with natural rubber from alternative plant sources. A further focus at the Aachen location is the utilization of anaerobic bacteria to produce various alcohols and jet fuel from off-gases from the steel industry. Another focus is the High Performance Center “Networked, Adaptive Production“ which has the aim to enable a much more flexible and efficient design of demanding value-added chains for the manufacture of Prof. Dr. Dr. Gerd Geißlinger Prof. Dr. Christoph Schäfers Prof. Dr. Stefan Schillberg technical and biological products. After three successful years, the three Fraunhofer Institutes IME, ILT and IPT in Aachen were granted a project extension of initially one more year with a planned consolidation from 2021 onwards, in order to exploit the opportunities offered by 4 5 »1« 60 years ago, the research laboratory at the Schmallen- berg location was inte- grated into the Fraunhofer- Gesellschaft. 7 GESCHICHTE AUS 60 JAHREN 60 YEARS OF HISTORY 2006 The division Molecular Biology moves into its own new 2015 Prof. Prüfer and Dr. Schulze Gronover, both Fraunhofer building near the RWTH Aachen University. IME, together with Dr. Recker from Continental Reifen Deutschland GmbH are awarded the Joseph von Fraunhofer The foundation of the Fraunhofer-Gesellschaft on March 1985 The Schmallenberg and Hanover locations are split 2008 The Fraunhofer Food Chain Management Alliance is Prize for their research on the Russian dandelion and the 26, 1949 laid the groundwork for the leading organization into two independent Fraunhofer Institutes. Renaming the founded. Under the leadership of the Fraunhofer IME division development of its application. in the field of applied research and development in Europe. Schmallenberg location Fraunhofer Institute for Environmental “Applied Ecology“, several Fraunhofer Institutes are working Fraunhofer IME is one of the first ten Fraunhofer Institutes. Chemistry and Ecotoxicology IUCT reflects the institute's new jointly to improve food safety. 2017 Prof. Fischer leaves Fraunhofer IME and hands over the research priorities. acting management to the head of the locations in Frankfurt 1959 On December 1, a research laboratory set up by Dr. 2009 A new Fraunhofer IME project group “Bioresources“ am Main, Schmallenberg und Aachen: Prof. Geißlinger, Prof. Bisa in Schmallenberg is integrated into the Fraunhofer- 1992 The Central Institute of Nutrition of the former Academy headed by Prof. Vilcinskas is established at the Justus Liebig Schäfers and Prof. Schillberg. Prof. Geißlinger is executive Gesellschaft named Fraunhofer Institute for Aerobiology IAe. of Sciences of the German Democratic Republic (GDR) is the University Gießen (JLU). In the following years insect biotech- director of Fraunhofer IME as well as Health Research Officer Construction of the main building begins in the same year. origin of the Fraunhofer IUCT branch “Department Biochem i- nology is established at the JLU and Fraunhofer. The location of the Fraunhofer-Gesellschaft. The institute is restructured cal Ecotoxicology“ in Potsdam. It is closed seven years later. in Gießen is appointed as a LOEWE
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