SSDI Manual: Appendix A

Effective with Cases Diagnosed 1/1/2018 and Forward

Published September 2019

Version 1.7

Table of Contents

Introduction ...... 6 Schema ID 00060: Cervical Lymph Nodes and Unknown Primary ...... 7 Schema ID 00071: Lip ...... 8 Schema ID 00072: Tongue Anterior ...... 9 Schema ID 00073: Gum ...... 10 Schema ID 00074: Floor of Mouth ...... 11 Schema ID 00075: Palate Hard ...... 12 Schema ID 00076: Buccal Mucosa ...... 13 Schema ID 00077: Mouth Other...... 14 Schema ID 00080: Major Salivary Glands ...... 15 Schema ID 00090: Nasopharynx ...... 16 Schema ID 00100: Oropharynx HPV-Mediated (p16+) ...... 17 Schema ID 00111: Oropharynx (p16-) ...... 18 Schema ID 00112: Hypopharynx ...... 19 Schema ID 00118: Pharynx Other ...... 20 Schema ID 00119: Middle Ear ...... 21 Schema ID 00121: Maxillary Sinus ...... 22 Schema ID 00122: Nasal Cavity and Ethmoid Sinus ...... 23 Schema ID 00128: Sinus Other ...... 24 Schema ID 00130: Larynx Other ...... 25 Schema ID 00131: Larynx Supraglottic ...... 26 Schema ID 00132: Larynx Glottic ...... 27 Schema ID 00133: Larynx Subglottic ...... 28 Schema ID 00140: Melanoma Head and Neck...... 29 Schema ID 00150: Cutaneous Carcinoma of Head and Neck ...... 31 Schema ID 00161: Esophagus (including GE junction) Squamous...... 32 Schema ID 00169: Esophagus (including GE junction) (excluding Squamous) ...... 33 Schema ID 00170: Stomach ...... 35 Schema ID 00180: Small Intestine ...... 36 Schema ID 00190: Appendix ...... 37 Schema ID 00200: Colon and Rectum ...... 38 Schema ID 00210: Anus ...... 39

2 | Page Version 1.7 Schema ID 00220: Liver ...... 40 Schema ID 00230: Bile Ducts Intrahepat ...... 41 Schema ID 00241: Gallbladder ...... 42 Schema ID 00242: Cystic Duct ...... 43 Schema ID 00250: Bile Ducts Perihilar ...... 44 Schema ID 00260: Bile Duct Distal ...... 45 Schema ID 00270: Ampulla of Vater ...... 46 Schema ID 00278: Biliary Other ...... 47 Schema ID 00280: Pancreas ...... 48 Schema ID 00288: Digestive Other ...... 49 Schema ID 00290: NET Stomach ...... 50 Schema ID 00301: NET Duodenum ...... 51 Schema ID 00302: NET Ampulla of Vater ...... 52 Schema ID 00310: NET Jejunum and Ileum ...... 53 Schema ID 00320: NET Appendix ...... 54 Schema ID 00330: NET Colon and Rectum ...... 55 Schema ID 00340: NET Pancreas ...... 56 Schema ID 00350: Thymus ...... 57 Schema ID 00358: Trachea ...... 58 Schema ID 00360: Lung ...... 59 Schema ID 00370: Pleural Mesothelioma ...... 60 Schema ID 00378: Respiratory Other ...... 61 Schema ID 00381: Bone Appendicular Skeleton ...... 62 Schema ID 00382: Bone Spine ...... 63 Schema ID 00383: Bone Pelvis ...... 64 Schema ID 00400: Soft Tissue Head and Neck ...... 65 Schema ID 00410: Soft Tissue Trunk and Extremities ...... 67 Schema ID 00421: Soft Tissue Abdomen and Thoracic ...... 68 Schema ID 00422: Heart, Mediastinum, and Pleura ...... 71 Schema ID 00430: GIST ...... 72 Schema ID 00440: Retroperitoneum ...... 74 Schema ID 00450: Soft Tissue Other ...... 75 Schema ID 00458: Kaposi Sarcoma ...... 79 Schema ID 00460: Merkel Cell Skin ...... 80

3 | Page Version 1.7 Schema ID 00470: Melanoma Skin ...... 81 Schema ID 00478: Skin Other ...... 82 Schema ID 00480: Breast ...... 83 Schema ID 00500: Vulva ...... 85 Schema ID 00510: Vagina ...... 86 Schema ID 00520: Cervix ...... 87 Schema ID 00530: Corpus Carcinoma and Carcinosarcoma...... 88 Schema ID 00541: Corpus Sarcoma ...... 89 Schema ID 00542: Corpus Adenosarcoma ...... 90 Schema ID 00551: Ovary ...... 91 Schema ID 00552: Primary Peritoneal Carcinoma ...... 93 Schema ID 00553: Fallopian Tube ...... 95 Schema ID 00558: Adnexa Uterine Other ...... 97 Schema ID 00559: Genital Female Other ...... 98 Schema ID 00560: Placenta ...... 99 Schema ID 00570: Penis ...... 100 Schema ID 00580: Prostate ...... 101 Schema ID 00590: Testis ...... 102 Schema ID 00598: Genital Male Other ...... 103 Schema ID 00600: Kidney Parenchyma ...... 104 Schema ID 00610: Kidney Renal Pelvis ...... 105 Schema ID 00620: Bladder ...... 106 Schema ID 00631: Urethra ...... 107 Schema ID 00633: Urethra-Prostatic ...... 108 Schema ID 00638: Urinary Other ...... 109 Schema ID 00640: Skin Eyelid ...... 110 Schema ID 00650: Conjunctiva ...... 111 Schema ID 00660: Melanoma Conjunctiva ...... 112 Schema ID 00671: Melanoma Iris...... 113 Schema ID 00672: Melanoma Choroid and Ciliary Body ...... 114 Schema ID 00680: Retinoblastoma ...... 115 Schema ID 00690: Lacrimal Gland ...... 116 Schema ID 00698: Lacrimal Sac ...... 117 Schema ID 00700: Orbital Sarcoma ...... 118

4 | Page Version 1.7 Schema ID 00710: Lymphoma Ocular Adnexa ...... 120 Schema ID 00718: Eye Other ...... 121 Schema ID 00721: Brain ...... 122 Schema ID 00722: CNS Other ...... 124 Schema ID 00723: Intracranial Gland ...... 127 Schema ID 00730: Thyroid ...... 129 Schema ID 00740: Thyroid Medullary ...... 130 Schema ID 00750: Parathyroid ...... 131 Schema ID 00760: Adrenal Gland ...... 132 Schema ID 00770: NET Adrenal Gland...... 133 Schema ID 00778: Endocrine Other ...... 134 Schema ID 00790: Lymphoma (excluding CLL/SLL) ...... 135 Schema ID 00795: Lymphoma-CLL/SLL ...... 137 Schema ID 00811: Mycosis Fungoides ...... 138 Schema ID 00812: Primary Cutaneous Lymphomas (excluding MF and SS) ...... 139 Schema ID 00821: Plasma Cell Myeloma ...... 140 Schema ID 00822: Plasma Cell Disorders ...... 141 Schema ID 00830: HemeRetic ...... 142 Schema ID 99999: Ill-Defined Other ...... 144

5 | Page Version 1.7 Introduction

Appendix A of the SSDI Manual is a listing of all the Schema ID’s and relevant schema ID information. The information included in this appendix is part of the cancer registry software. This document can be used for a reference.

For surveillance and software purposes, every combination of primary site and histology must be accounted for in Summary Stage. The Summary Stage 2018 update was based on changes in AJCC 8th edition and how data has been collected historically.

Schema ID defines the assignment of the following as it applies to primary site(s), histology(ies) and Schema Discriminator fields-based results for:

• AJCC Chapter • EOD Schema • Summary Stage 2018 • Applicable site-specific data items (SSDIs) • Grade Table • AJCC ID o The AJCC ID identifies which of the primary site/histology combinations within the schema ID are eligible for AJCC 8th edition stage

6 | Page Version 1.7 Schema ID 00060: Cervical Lymph Nodes and Unknown Primary

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C760 8000-8700, 8720-8790, 8941, 9700-9701 2, 3, 4, 5

AJCC Chapter 6: Cervical Lymph Nodes and Unknown Primary Tumors of the Head and Neck EOD Schema: Cervical Lymph Nodes and Unknown Primary Summary Stage 2018 Chapter: Cervical Lymph Nodes and Unknown Primary Tumors of Head and Neck

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3876: LN Head and Neck Levels I-III • NAACCR # 3877: LN Head and Neck Levels IV-V • NAACCR # 3878: LN Head and Neck Levels VI-VII • NAACCR # 3879: LN Head and Neck Other • NAACCR # 3883: LN Size • NAACCR # 3926: Schema Discriminator 1 (Occult Head and Neck Lymph Nodes)

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 6: Cervical Lymph Nodes and Unknown Primary Tumors of Head and Neck

Histology Behavior AJCC ID Description 8010, 8046, 8051-8052, 8070-8074, 8082-8084, 3 6 Cervical Lymph Nodes 8121, 8140, 8147, 8200, 8310, 8430, 8450, 8480, and Unknown Primary 8525, 8550, 8562, 8941 Tumors of the Head and Neck 8010, 8046, 8051-8052, 8070-8074, 8082-8084, 2 XX Other Cervical Lymph 8121, 8140, 8147, 8200, 8310, 8430, 8450, 8480, Nodes and Unknown 8525, 8550, 8562, 8941 Primary Tumors of the Head and Neck 8000-8005, 8011-8045, 8050, 8053-8060, 8075- Nodes and Unknown 8191, 8201-8300, 8311-8420, 8440-8444, 8451- Primary Tumors of the 8474, 8481-8524, 8530-8543, 8551-8561, 8570- Head and Neck 8700, 8720-8790, 9700-9701

7 | Page Version 1.7 Schema ID 00071: Lip

Primary Site(s)/Histology(ies) Primary Site Histology C003-C005, C008, C009 8000-8040, 8042-8180, 8191-8246, 8248-8700, 8982, 9700-9701

AJCC Chapter 7: Oral Cavity EOD Schema: Lip Summary Stage 2018 Chapter: Lip

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 7: Oral Cavity

Histology AJCC ID Description 8000, 8010, 8051-8052, 8070-8072, 8074-8075, 8082-8083, 8140, 8147, 7 Oral Cavity 8200, 8290, 8310, 8430, 8480, 8500, 8525, 8550, 8560, 8562, 8982 8001-8005, 8011-8040, 8042-8050, 8053-8060, 8073, 8076-8081, 8084- XX Other Oral 8131, 8141-8146, 8148-8180, 8191, 8201-8246, 8248-8281, 8300, 8311- Cavity 8420, 8440-8474, 8481-8490, 8501-8524, 8530-8543, 8551-8552, 8561, 8570-8700, 9700-9701

8 | Page Version 1.7 Schema ID 00072: Tongue Anterior

Primary Site(s)/Histology(ies) Primary Site Histology C020-C023, C028-C029 8000-8700, 8982, 9700-9701

AJCC Chapter 7: Oral Cavity EOD Schema: Tongue Anterior Summary Stage 2018 Chapter: Tongue Anterior

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 7: Oral Cavity

Histology AJCC ID Description 8000, 8010, 8051-8052, 8070-8072, 8074-8075, 8082-8083, 8140, 8147, 7 Oral Cavity 8200, 8290, 8310, 8430, 8480, 8500, 8525, 8550, 8560, 8562, 8982 8001-8005, 8011-8050, 8053-8060, 8073, 8076-8081, 8084-8131, 8141- XX Other Oral 8146, 8148-8191, 8201-8281, 8300, 8311-8420, 8440-8474, 8481-8490, Cavity 8501-8524, 8530-8543, 8551-8552, 8561, 8570-8700, 9700-9701

9 | Page Version 1.7 Schema ID 00073: Gum

Primary Site(s)/Histology(ies) Primary Site Histology C030, C031, C039, C062 8000-8700, 8982, 9700-9701

AJCC Chapter 7: Oral Cavity EOD Schema: Gum Summary Stage 2018 Chapter: Gum

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 7: Oral Cavity

Histology AJCC ID Description 8000, 8010, 8051-8052, 8070-8072, 8074-8075, 8082-8083, 8140, 8147, 7 Oral Cavity 8200, 8290, 8310, 8430, 8480, 8500, 8525, 8550, 8560, 8562, 8982 8001-8005, 8011-8050, 8053-8060, 8073, 8076-8081, 8084-8131, 8141-8146, XX Other Oral 8148-8191, 8201-8281, 8300, 8311-8420, 8440-8474, 8481-8490, 8501-8524, Cavity 8530-8543, 8551-8552, 8561, 8570-8700, 9700-9701

10 | Page Version 1.7 Schema ID 00074: Floor of Mouth

Primary Site(s)/Histology(ies) Primary Site Histology C040-C041, C048-C049 8000-8700, 8982, 9700-9701

AJCC Chapter 7: Oral Cavity EOD Schema: Floor of Mouth Summary Stage 2018 Chapter: Floor of Mouth

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 7: Oral Cavity

Histology AJCC ID Description 8000, 8010, 8051-8052, 8070-8072, 8074-8075, 8082-8083, 8140, 8147, 7 Oral Cavity 8200, 8290, 8310, 8430, 8480, 8500, 8525, 8550, 8560, 8562, 8982 8001-8005, 8011-8050, 8053-8060, 8073, 8076-8081, 8084-8131, 8141-8146, XX Other Oral 8148-8191, 8201-8281, 8300, 8311-8420, 8440-8474, 8481-8490, 8501-8524, Cavity 8530-8543, 8551-8552, 8561, 8570-8700, 9700-9701

11 | Page Version 1.7 Schema ID 00075: Palate Hard

Primary Site(s)/Histology(ies) Primary Site Histology C050 8000-8700, 8982, 9700-9701

AJCC Chapter 7: Oral Cavity EOD Schema: Palate Hard Summary Stage 2018 Chapter: Palate Hard

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 7: Oral Cavity

Histology AJCC ID Description 8000, 8010, 8051-8052, 8070-8072, 8074-8075, 8082-8083, 8140, 8147, 7 Oral Cavity 8200, 8290, 8310, 8430, 8480, 8500, 8525, 8550, 8560, 8562, 8982 8001-8005, 8011-8050, 8053-8060, 8073, 8076-8081, 8084-8131, 8141-8146, XX Other Oral 8148-8191, 8201-8281, 8300, 8311-8420, 8440-8474, 8481-8490, 8501-8524, Cavity 8530-8543, 8551-8552, 8561, 8570-8700, 9700-9701

12 | Page Version 1.7 Schema ID 00076: Buccal Mucosa

Primary Site(s)/Histology(ies) Primary Site Histology C060-C061 8000-8700, 8982, 9700-9701

AJCC Chapter 7: Oral Cavity EOD Schema: Buccal Mucosa Summary Stage 2018 Chapter: Buccal Mucosa

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 7: Oral Cavity

Histology AJCC ID Description 8000, 8010, 8051-8052, 8070-8072, 8074-8075, 8082-8083, 8140, 8147, 7 Oral Cavity 8200, 8290, 8310, 8430, 8480, 8500, 8525, 8550, 8560, 8562, 8982 8001-8005, 8011-8050, 8053-8060, 8073, 8076-8081, 8084-8131, 8141-8146, XX Other Oral 8148-8191, 8201-8281, 8300, 8311-8420, 8440-8474, 8481-8490, 8501-8524, Cavity 8530-8543, 8551-8552, 8561, 8570-8700, 9700-9701

13 | Page Version 1.7 Schema ID 00077: Mouth Other

Primary Site(s)/Histology(ies) Primary Site Histology C058-C059, C068-C069 8000-8700, 8982, 9700-9701

AJCC Chapter 7: Oral Cavity EOD Schema: Mouth Other Summary Stage 2018 Chapter: Mouth Other

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 7: Oral Cavity

Histology AJCC ID Description 8000, 8010, 8051-8052, 8070-8072, 8074-8075, 8082-8083, 8140, 8147, 7 Oral Cavity 8200, 8290, 8310, 8430, 8480, 8500, 8525, 8550, 8560, 8562, 8982 8001-8005, 8011-8050, 8053-8060, 8073, 8076-8081, 8084-8131, 8141-8146, XX Other Oral 8148-8191, 8201-8281, 8300, 8311-8420, 8440-8474, 8481-8490, 8501-8524, Cavity 8530-8543, 8551-8552, 8561, 8570-8700, 9700-9701

14 | Page Version 1.7 Schema ID 00080: Major Salivary Glands

Primary Site(s)/Histology(ies) Primary Site Histology C079, C080-C081, C088-C089 8000-8700, 8720-8790, 8941, 8974, 8980, 8982, 9700-9701

AJCC Chapter 8: Major Salivary Glands EOD Schema: Major Salivary Glands Summary Stage 2018 Chapter: Major Salivary Glands

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 8: Major Salivary Glands

Histology AJCC ID Description 8000, 8010, 8013, 8041, 8046, 8070-8072, 8074, 8082-8083, 8140, 8147, 8 Major Salivary 8200, 8246, 8290, 8310, 8410, 8430, 8500, 8502, 8525, 8550, 8560, Glands 8562, 8941, 8974, 8980, 8982 8001-8005, 8011-8012, 8014-8040, 8042-8045, 8050-8060, 8073, 8075- XX Other Major 8081, 8084-8131, 8141-8146, 8148-8191, 8201-8245, 8247-8281, 8300, Salivary 8311-8409, 8413-8420, 8440-8490, 8501, 8503-8524, 8530-8543, 8551- Glands 8552, 8561, 8570-8700, 8720-8790, 9700-9701

15 | Page Version 1.7 Schema ID 00090: Nasopharynx

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C110, C112-C113, C118-C119 8000-8700, 9700-9701 C111 8000-8700, 9700-9701 1

AJCC Chapter 9: Nasopharynx EOD Schema: Nasopharynx Summary Stage 2018 Chapter: Nasopharynx

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size • NAACCR # 3926: Schema Discriminator 1 (Nasopharynx/PharyngealTonsil)

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 9: Nasopharynx

Histology AJCC ID Description 8000, 8010, 8020, 8052, 8070-8073, 8083, 8140, 8200 9 Nasopharynx 8001-8005, 8011-8015, 8021-8051, 8053-8060, 8074-8082, 8084-8131, XX Other 8141-8191, 8201-8700, 9700-9701 Nasopharynx

16 | Page Version 1.7 Schema ID 00100: Oropharynx HPV-Mediated (p16+)

Primary Site(s)/Histology(ies) Primary Site Histology Schema Schema Discriminator 1 Discriminator 2 C019, C024, C051-C052, C090-C091, 8000-8700, 9700- 2 C098-C099, C100, C102-C104, C108-C109 9701 C111 8000-8700, 9700- 2 2 9701

AJCC Chapter 10: HPV-Mediated (p16+) Oropharyngeal Cancer EOD Schema: Oropharynx HPV-Mediated (p16+) Summary Stage 2018 Chapter: Oropharynx

Applicable SSDIs

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 10: Oropharynx HPV-Mediated (p16+)

Primary Site Histology Behavior AJCC ID Description C019, C024, C051-C052, 8070, 8072, 8083, 3 10 HPV-Mediated (p16+) C090-C099, C100, C102- 8085 Oropharyngeal Cancer C103, C108-C109, C111 C019, C024, C051-C052, 8070, 8072, 8083, 2 XX Other HPV-Mediated C090-C099, C100, C102- 8085 (p16+) Oropharyngeal C103, C108-C109, C111 Cancer C104 8070, 8072, 8083, (p16+) Oropharyngeal Cancer C019, C024, C051-C052, 8000-8060, 8071, (p16+) Oropharyngeal C104, C108-C109, C111 8086-8700, 9700-9701 Cancer

17 | Page Version 1.7 Schema ID 00111: Oropharynx (p16-)

Primary Site(s)/Histology(ies) Primary Site Histology Schema Schema Discriminator 1 Discriminator 2 C019, C024, C051-C052, C090-C091, 8000-8700, 9700- 1,9 C098-C099, C100, C102-C104, C108-C109 9701 C111 8000-8700, 9700- 2 1,9 9701

AJCC Chapter 11: Oropharynx (p16-) and Hypopharynx EOD Schema: Oropharynx (p16-) Summary Stage 2018 Chapter: Oropharynx

Applicable SSDIs

Grade Table 02:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 4 G4: Undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 11.1: Oropharynx (p16-)

Primary Site Histology AJCC ID Description C019, C024, C051-C052, C090- 8051-8052, 8070, 8074-8075, 8082- 11.1 Oropharynx C099, C100, C102-C103, C108- 8083, 8086, 8560 (p16-) C109, C111 C104 8051-8052, 8070, 8074-8075, 8082- XX Other 8083, 8086, 8560 Oropharynx (p16-) C019, C024, C051-C052, C090- 8000-8050, 8053-8060, 8071-8073, XX Other C099, C100, C102-C104, C108- 8076-8081, 8084-8085, 8090-8552, Oropharynx C109, C111 8561-8700, 9700-9701 (p16-)

18 | Page Version 1.7 Schema ID 00112: Hypopharynx

Primary Site(s)/Histology(ies) Primary Site Histology C129, C130-C132, C138-C139 8000-8700, 9700-9701

AJCC Chapter 11: Oropharynx (p16-) and Hypopharynx EOD Schema: Hypopharynx Summary Stage 2018 Chapter: Hypopharynx

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 02:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 4 G4: Undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 11.2: Hypopharynx

Histology AJCC ID Description 8051-8052, 8070, 8074-8075, 8082-8083, 8086, 8560 11.2 Hypopharynx 8000-8050, 8053-8060, 8071-8073, 8076-8081, 8084-8085, 8090-8552, XX Other 8561-8700, 9700-9701 Hypopharynx

19 | Page Version 1.7 Schema ID 00118: Pharynx Other

Primary Site(s)/Histology(ies) Primary Site Histology C140, C142, C148 8000-8700, 9700-9701

AJCC Chapter: None EOD Schema: Pharynx Other Summary Stage 2018 Chapter: Pharynx Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

20 | Page Version 1.7 Schema ID 00119: Middle Ear

Primary Site(s)/Histology(ies) Primary Site Histology C301 8000-8700, 9700-9701

AJCC Chapter: None EOD Schema: Middle Ear Summary Stage 2018 Chapter: Middle Ear

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

21 | Page Version 1.7 Schema ID 00121: Maxillary Sinus

Primary Site(s)/Histology(ies) Primary Site Histology C310 8000-8700, 8941, 8982, 9700-9701

AJCC Chapter 12: Nasal Cavity and Paranasal Sinuses EOD Schema: Maxillary Sinus Summary Stage 2018 Chapter: Nasal Cavity and Paranasal Sinuses

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 12.1: Maxillary Sinus

Histology AJCC ID Description 8000, 8010, 8013, 8020, 8023, 8041, 8051-8052, 8070-8072, 8074-8075, 12.1 Maxillary 8082-8083, 8140, 8144, 8200, 8240, 8249, 8310, 8430, 8525, 8560, 8562, Sinus 8941, 8982 8001-8005, 8011-8012, 8014-8015, 8021-8022, 8030-8040, 8042-8050, XX Other 8053-8060, 8073, 8076-8081, 8084-8131, 8141-8143, 8145-8191, 8201-8231, Maxillary 8241-8248, 8250-8300, 8311-8420, 8440-8524, 8530-8552, 8561, 8570-8700, Sinus 9700-9701

22 | Page Version 1.7 Schema ID 00122: Nasal Cavity and Ethmoid Sinus

Primary Site(s)/Histology(ies) Primary Site Histology C300, C311 8000-8700, 8941, 8982, 9700-9701

AJCC Chapter 12: Nasal Cavity and Paranasal Sinuses EOD Schema: Nasal Cavity and Ethmoid Sinus Summary Stage 2018 Chapter: Nasal Cavity and Paranasal Sinuses

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 12.2: Nasal Cavity and Ethmoid Sinus

Histology AJCC ID Description 8000, 8010, 8013, 8020, 8023, 8041, 8051-8052, 8070-8072, 8074-8075, 12.2 Nasal Cavity and 8082-8083, 8140, 8144, 8200, 8240, 8249, 8310, 8430, 8525, 8560, Ethmoid Sinus 8562, 8941, 8982 8001-8005, 8011-8012, 8014-8015, 8021-8022, 8030-8040, 8042-8050, XX Other Nasal Cavity 8053-8060, 8073, 8076-8081, 8084-8131, 8141-8143, 8145-8191, 8201- and Ethmoid Sinus 8231, 8241-8248, 8250-8300, 8311-8420, 8440-8524, 8530-8552, 8561, 8570-8700, 9700-9701

23 | Page Version 1.7 Schema ID 00128: Sinus Other

Primary Site(s)/Histology(ies) Primary Site Histology C312-C313, C318-C319 8000-8700, 9700-9701

AJCC Chapter: None EOD Schema: Sinus Other Summary Stage 2018 Chapter: Sinus Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

24 | Page Version 1.7 Schema ID 00130: Larynx Other

Primary Site(s)/Histology(ies) Primary Site Histology C323, C328-C329 8000-8700, 9700-9701

AJCC Chapter 13: Larynx EOD Schema: Larynx Other Summary Stage 2018 Chapter: Larynx Other

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 13.0: Larynx Other

Primary Site Histology AJCC ID Description C328-C329 8000, 8010, 8013, 8041, 8045, 8051-8052, 8070-8072, 8074- 13.0 Larynx: NOS 8075, 8082-8083, 8200, 8240, 8249, 8430, 8560 C323 8000, 8010, 8013, 8041, 8045, 8051-8052, 8070-8072, 8074- XX Other Larynx: 8075, 8082-8083, 8200, 8240, 8249, 8430, 8560 NOS C323, C328- 8001-8005, 8011-8012, 8014-8040, 8042-8044, 8046-8050, XX Other Larynx: C329 8053-8060, 8073, 8076-8081, 8084-8191, 8201-8231, 8241- NOS 8248, 8250-8420, 8440-8552, 8561-8700, 9700-9701

25 | Page Version 1.7 Schema ID 00131: Larynx Supraglottic

Primary Site(s)/Histology(ies) Primary Site Histology C101, C321 8000-8700, 9700-9701

AJCC Chapter 13: Larynx EOD Schema: Larynx Supraglottic Summary Stage 2018 Chapter: Larynx Supraglottic

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 13.1: Larynx Supraglottic

Histology AJCC ID Description 8000, 8010, 8013, 8041, 8045, 8051-8052, 8070-8072, 8074-8075, 8082- 13.1 Larynx: 8083, 8200, 8240, 8249, 8430, 8560 Supraglottis 8001-8005, 8011-8012, 8014-8040, 8042-8044, 8046-8050, 8053-8060, XX Other Larynx: 8073, 8076-8081, 8084-8191, 8201-8231, 8241-8248, 8250-8420, 8440- Supraglottis 8552, 8561-8700, 9700-9701

26 | Page Version 1.7 Schema ID 00132: Larynx Glottic

Primary Site(s)/Histology(ies) Primary Site Histology C320 8000-8700, 9700-9701

AJCC Chapter 13: Larynx EOD Schema: Larynx Glottic Summary Stage 2018 Chapter: Larynx Glottic

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 13.2: Larynx Glottic

Histology AJCC ID Description 8000, 8010, 8013, 8041, 8045, 8051-8052, 8070-8072, 8074-8075, 8082- 13.2 Larynx: Glottis 8083, 8200, 8240, 8249, 8430, 8560 8001-8005, 8011-8012, 8014-8040, 8042-8044, 8046-8050, 8053-8060, XX Other Larynx: 8073, 8076-8081, 8084-8191, 8201-8231, 8241-8248, 8250-8420, 8440- Glottis 8552, 8561-8700, 9700-9701

27 | Page Version 1.7 Schema ID 00133: Larynx Subglottic

Primary Site(s)/Histology(ies) Primary Site Histology C322 8000-8700, 9700-9701

AJCC Chapter 13: Larynx EOD Schema: Larynx Subglottic Summary Stage 2018 Chapter: Larynx Subglottic

Applicable SSDIs

• NAACCR # 3831: Extranodal Extension Head and Neck Clinical • NAACCR # 3832: Extranodal Extension Head and Neck Pathological • NAACCR # 3883: LN Size

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 13.2: Larynx Glottic

Histology AJCC ID Description 8000, 8010, 8013, 8041, 8045, 8051-8052, 8070-8072, 8074-8075, 8082- 13.3 Larynx: 8083, 8200, 8240, 8249, 8430, 8560 Subglottis 8001-8005, 8011-8012, 8014-8040, 8042-8044, 8046-8050, 8053-8060, XX Other Larynx: 8073, 8076-8081, 8084-8191, 8201-8231, 8241-8248, 8250-8420, 8440- Subglottis 8552, 8561-8700, 9700-9701

28 | Page Version 1.7 Schema ID 00140: Melanoma Head and Neck

Primary Site(s)/Histology(ies) Primary Site Histology C003-C005, C008-C009, C019, C020-C024, C028-C029, C030-C031, C039, C040-C041, 8720- C048-C049, C050-C052, C058-C059, C060-C062, C068-C069, C079-C81, C088-C089, C090- 8790 C091, C098-C099, C100-C104, C108-C109, C110-C113, C118-C119, C129, C130-C132, C138-C139, C140, C142, C148, C300-C313, C318-C319, C320-C323, C328-C329

AJCC Chapter 14: Mucosal Melanoma of the Head and Neck EOD Schema: Melanoma of the Head and Neck Summary Stage 2018 Chapter: Melanoma of the Head and Neck

Applicable SSDIs

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 14: Melanoma Head and Neck

Primary Site Histology Behavior AJCC ID Description C003-C005, C008-C009, C019-C069, 8720-8722, 8730, 3 14 Mucosal Melanoma C090-C091, C098-C099, C100-C103, 8745-8746, 8770- of the Head and C108-C109, C110-C148, C300, C310- 8772 Neck C311, C320-C322, C328-C329 C003-C005, C008-C009, C019-C069, 8720-8722, 8730, 2 XX Other Mucosal C090-C091, C098-C099, C100-C103, 8745-8746, 8770- Melanoma of the C108-C109, C110-C148, C300, C310- 8772 Head and Neck C311, C320-C322, C328-C329 C104, C301, C312-C313, C318-C319, 8720-8722, 8730, Melanoma of the 8772 Head and Neck C003-C005, C008-C009, C019-C069, 8723-8728, 8740- Melanoma of the 8773-8790 Head and Neck

29 | Page Version 1.7 Primary Site Histology Behavior AJCC ID Description C079-C082, C088-C089 8723-8728, 8740- 2, 3 XX Other Mucosal 8744, 8750-8762, Melanoma of the 8773-8790 Head and Neck

30 | Page Version 1.7 Schema ID 00150: Cutaneous Carcinoma of Head and Neck

Primary Site(s)/Histology(ies) Primary Site Histology C000-C002, C006, C440, C442-C444 8000-8040, 8042-8180, 8191-8246, 8248-8700, 8940, 8982

AJCC Chapter 15: Cutaneous Head and Neck EOD Schema: Cutaneous Carcinoma of Head and Neck Summary Stage 2018 Chapter: Skin (except Eyelid)

Applicable SSDIs

• NAACCR # 3858: High Risk Histologic Features • NAACCR # 3883: LN Size • NAACCR # 3909: Perineural Invasion

Grade Table 02:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 4 G4: Undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 15: Cutaneous Carcinoma of the Head and Neck

Primary Site Histology AJCC ID Description C000-C002, 8070, 8090-8093, 8103, 8110, 8200, 8211, 8400- 15 Cutaneous Carcinoma C006, C440, 8401, 8403, 8407-8410, 8480, 8940, 8982 of the Head and Neck C442-C444 C000-C002, 8000-8040, 8042-8060, 8071-8086, 8094-8102, XX Other Cutaneous C006, C440, 8120-8180, 8191, 8201-8210, 8212-8246, 8248- Carcinoma of the Head C442-C444 8392, 8402, 8404-8406, 8413-8474, 8481-8700 and Neck

31 | Page Version 1.7 Schema ID 00161: Esophagus (including GE junction) Squamous

Primary Site(s)/Histology(ies) Primary Site Histology Schema Schema Discriminator 1 Discriminator 2 C150-C155, C158- 8050-8054, 8070, 8074, 8077, C159 8083, 8560 C160 8050-8054, 8070, 8074, 8077, 2 8083, 8560 C150-C155, C158- 8020 1, 9 C159 C160 8020 2 1, 9

AJCC Chapter 16: Esophagus and Esophagogastric Junction EOD Schema: Esophagus (including GE junction) Squamous Summary Stage 2018 Chapter: Esophagus

Applicable SSDIs

• NAACCR # 3829: Esophagus and EGJ Tumor Epicenter • NAACCR # 3926: Schema Discriminator 1 (EsophagusGEJunction (EGJ)/Stomach) (primary site C160) • NAACCR # 3927: Schema Discriminator 2 (Histology Discriminator for 8020/3)

Grade Table 03:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated, undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 16.1: Esophagus and Esophagogastric Junction: Squamous Cell Carcinoma

Histology Behavior AJCC ID Description 8020 3 16.1 Esophagus and Esophagogastric Junction: Squamous Cell Carcinoma 8020 2 XX Other Esophagus and Esophagogastric Junction: Squamous Cell Carcinoma 8051, 8070, 8074, 8077, Squamous Cell Carcinoma 8050, 8052-8054 Squamous Cell Carcinoma

32 | Page Version 1.7 Schema ID 00169: Esophagus (including GE junction) (excluding Squamous)

Primary Site(s)/Histology(ies) Primary Site Histology Schema Schema Discriminator 1 Discriminator 2 C150-C155, 8000-8015, 8021-8046, 8060, 8071-8073, 8075- C158-C159 8076, 8078-8082, 8084-8552, 8561-8700, 8720- 8790, 9700-9701 C160 8000-8015, 8021-8046, 8060, 8071-8073, 8075- 2 8076, 8078-8082, 8084-8149, 8154, 8157, 8160- 8231, 8243-8248, 8250-8552, 8561-8682, 8690- 8700, 8720-8790, 9700-9701 C150-C155, 8020 2 C158-C159 C160 8020 2 2

AJCC Chapter 16: Esophagus and Esophagogastric Junction EOD Schema: Esophagus (including GE junction) (excluding Squamous) Summary Stage 2018 Chapter: Esophagus

Applicable SSDIs

• NAACCR # 3926: Schema Discriminator 1 (EsophagusGEJunction (EGJ)/Stomach) (primary site C160) • NAACCR # 3927: Schema Discriminator 2 (Histology Discriminator for 8020/3)

Grade Table 03:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated, undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 16.2: Esophagus and Esophagogastric Junction: Adenocarcinoma AJCC ID 16.3: Esophagus and Esophagogastric Junction: Other Histologies

Primary Site Histology Behavior AJCC ID Description C150-C155, C158- 8000, 8010, 8013, 8041, 8071, 8145, Esophagogastric Junction: Other Histologies C150-C155, C158- 8020 3 16.2 Esophagus and C159, C160 Esophagogastric Junction: Adenocarcinoma

33 | Page Version 1.7 Primary Site Histology Behavior AJCC ID Description C150-C155, C158- 8020 2 XX Other Esophagus and C159, C160 Esophagogastric Junction: C150-C155, C158- 8140, 8148, 8200, 8244, 8430 Esophagogastric Junction: Adenocarcinoma C150-C155, C158- 8240, 8249 Esophagogastric Junction: Other Histologies C150-C155, C158- 8001-8005, 8011-8012, 8014-8015, Esophagogastric 8073, 8075-8076, 8078-8082, 8084- Junction 8131, 8141-8144, 8146-8147, 8149, 8154, 8157, 8160-8191, 8201-8231, 8243, 8245, 8247-8248, 8250-8254, 8256-8420, 8440-8552, 8561-8682, 8690-8700, 8720-8790, 9700-9701 C150-C155, C158- 8150-8153, 8155-8156, 8158, 8241- Esophagogastric Junction

34 | Page Version 1.7 Schema ID 00170: Stomach

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C160 8000-8149, 8154, 8157, 8160-8231, 8243-8248, 8250-8682, 0, 3, 9 8690-8700, 8720-8790, 9700-9701 C161-C166, 8000-8149, 8154, 8157, 8160-8231, 8243-8248, 8250-8682, C168-C169 8690-8700, 8720-8790, 9700-9701

AJCC Chapter 17: Stomach EOD Schema: Stomach Summary Stage 2018 Chapter: Stomach (including NET)

Applicable SSDIs

• NAACCR # 3926: Schema Discriminator 1 (EsophagusGEJunction (EGJ)/Stomach) (primary site C160)

Grade Table 04:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated, undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 17: Stomach

Histology AJCC ID Description 8000, 8010, 8013, 8020, 8041, 8070, 8082, 8140, 8142, 8144-8145, 8148, 8211, 17 Stomach 8214, 8244, 8246, 8255, 8260, 8480, 8490, 8510, 8512, 8560, 8576 8001-8005, 8011-8012, 8014-8015, 8021-8040, 8042-8060, 8071-8081, 8083- XX Other 8131, 8141, 8143, 8146-8147, 8149, 8154, 8157, 8160-8210, 8212-8213, 8215- Stomach 8231, 8243, 8245, 8247-8248, 8250-8254, 8256-8257, 8261-8474, 8481-8482, 8500-8509, 8513-8552, 8561-8575, 8580-8682, 8690-8700, 8720-8790, 9700- 9701

35 | Page Version 1.7 Schema ID 00180: Small Intestine

Primary Site(s)/Histology(ies) Primary Site Histology C170-C173, C178- 8000-8149, 8154, 8157, 8160-8231, 8243-8248, 8250-8682, 8690-8700, 8720- C179 8790, 9700-9701

AJCC Chapter 18: Small Intestine EOD Schema: Small Intestine Summary Stage 2018 Chapter: Small Intestine (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 02:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 4 G4: Undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 18.1: Small Intestine: Adenocarcinoma AJCC ID 18.2: Small Intestine: Other Histologies

Primary Site Histology AJCC ID Description C170-C172, 8010, 8140, 8210, 8261, 8263, 8480-8481, 8490 18.1 Small Intestine: C178-C179 Adenocarcinoma C170-C172, 8000, 8013, 8020, 8041, 8070, 8148, 8244, 8255, 8510, 18.2 Small Intestine: C178-C179 8560 Other Histologies C173 8000, 8010, 8013, 8020, 8041, 8070, 8140, 8148, 8210, XX Other Small 8244, 8255, 8261, 8263, 8480-8481, 8490, 8510, 8560 Intestine C170-C173, 8001-8005, 8011-8012, 8014-8015, 8021-8040, 8042- XX Other Small C178-C179 8060, 8071-8131, 8141-8147, 8149, 8154, 8157, 8160- Intestine 8204, 8211-8231, 8243, 8245-8248, 8250-8254, 8256- 8260, 8262, 8264-8474, 8482, 8500-8509, 8512-8552, 8561-8682, 8690-8700, 8720-8790, 9700-9701

36 | Page Version 1.7 Schema ID 00190: Appendix

Primary Site(s)/Histology(ies) Primary Site Histology C181 8000-8149, 8154, 8157, 8160-8231, 8243-8248, 8250-8682, 8690-8700, 8720-8790, 9700-9701

AJCC Chapter 19: Appendix EOD Schema: Appendix Summary Stage 2018 Chapter: Appendix (including NET)

Applicable SSDIs

• NAACCR # 3819: CEA Pretreatment Interpretation • NAACCR # 3820: CEA Pretreatment Lab Value

Grade Table 05:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 19: Appendix

Histology AJCC ID Description 8000, 8010, 8013, 8020, 8041, 8070, 8140, 8148, 8210, 8243-8246, 8255, 19 Appendix 8480-8481, 8490, 8510, 8560 8001-8005, 8011-8012, 8014-8015, 8021-8040, 8042-8060, 8071-8131, 8141- XX Other 8147, 8149, 8154, 8157, 8160-8204, 8211-8231, 8247-8248, 8250-8254, 8256- Appendix 8474, 8482, 8500-8509, 8512-8552, 8561-8682, 8690-8700, 8720-8790, 9700- 9701

37 | Page Version 1.7 Schema ID 00200: Colon and Rectum

Primary Site(s)/Histology(ies) Primary Site Histology C180, C182-C189, C199, 8000-8149, 8154, 8157, 8160-8231, 8243-8248, 8250-8682, 8690-8700, C209 8720-8790, 9700-9701

AJCC Chapter 20: Colon and Rectum EOD Schema: Colon and Rectum Summary Stage 2018 Chapter: Colon and Rectum (including NET)

Applicable SSDIs

• NAACCR # 3819: CEA Pretreatment Interpretation • NAACCR # 3820: CEA Pretreatment Lab Value • NAACCR # 3823: Circumferential Resection Margin (CRM) • NAACCR # 3866: KRAS • NAACCR # 3890: Microsatellite Instability (MSI) • NAACCR # 3909: Perineural Invasion • NAACCR # 3934: Tumor Deposits

Grade Table 02:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 4 G4: Undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 20: Colon and Rectum

Histology AJCC ID Description 8000, 8010, 8013, 8020, 8041, 8070, 8140, 8213, 8246, 8265, 8480-8481, 20 Colon and 8490, 8510, 8560 Rectum 8001-8005, 8011-8012, 8014-8015, 8021-8040, 8042-8060, 8071-8131, XX Other Colon 8141-8149, 8154, 8157, 8160-8212, 8214-8231, 8243-8245, 8247-8248, and Rectum 8250-8264, 8270-8474, 8482, 8500-8509, 8512-8552, 8561-8682, 8690- 8700, 8720-8790, 9700-9701

38 | Page Version 1.7 Schema ID 00210: Anus

Primary Site(s)/Histology(ies) Primary Site Histology C210-C212, C218 8000-8700, 8720-8790, 9700-9701

AJCC Chapter 21: Anus EOD Schema: Anus Summary Stage 2018 Chapter: Anus

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 06:

Code Grade Description 1 G1: Well differentiated (low grade) 2 G2: Moderately differentiated (low grade) 3 G3: Poorly differentiated (high grade) 4 G4: Undifferentiated (high grade) L Stated as “low grade” NOS H Stated as “high grade” NOS 9 Grade cannot be assessed (GX); Unknown

AJCC ID 21: Anus

Primary Site Histology AJCC ID Description C210-C211, 8000, 8010, 8013, 8020, 8041, 8051, 8070-8072, 8077, 8083, 21 Anus C218 8090, 8123-8124, 8140, 8244, 8246, 8480, 8542 C212 8000, 8010, 8013, 8020, 8041, 8051, 8070-8072, 8077, 8083, XX Other Anus 8090, 8123-8124, 8140, 8244, 8246, 8480, 8542 C210-C212, 8001-8005, 8011-8012, 8014-8015, 8021-8040, 8042-8050, XX Other Anus C218 8052-8060, 8073-8076, 8078-8082, 8084-8086, 8091-8122, 8130-8131, 8141-8243, 8245, 8247-8474, 8481-8541, 8543- 8700, 8720-8790, 9700-9701

39 | Page Version 1.7 Schema ID 00220: Liver

Primary Site(s)/Histology(ies) Primary Site Histology C220 8000-8700, 8720-8790, 9700-9701

AJCC Chapter 22: Liver EOD Schema: Liver Summary Stage 2018 Chapter: Liver

Applicable SSDIs

• NAACCR # 3809: AFP Pretreatment Interpretation • NAACCR # 3810: AFP Pretreatment Lab Value • NAACCR # 3813: Bilirubin Pretreatment Total Lab Value • NAACCR # 3814: Bilirubin Pretreatment Unit of Measure • NAACCR # 3824: Creatinine Pretreatment Lab Value • NAACCR # 3825: Creatinine Pretreatment Unit of Measure • NAACCR # 3835: Fibrosis Score • NAACCR # 3860: International Normalized Ratio

Grade Table 02:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 4 G4: Undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 22: Liver

Histology Behavior AJCC ID Description 8170-8174 3 22 Liver 8170-8174 2 XX Other Liver 8000-8163, 8175-8700, 8720-8790, 9700-9701 XX Other Liver

40 | Page Version 1.7 Schema ID 00230: Bile Ducts Intrahepat

Primary Site(s)/Histology(ies) Primary Site Histology C221 8000-8700, 8720-8790, 8980, 9700-9701

AJCC Chapter 23: Intrahepatic Bile Ducts EOD Schema: Bile Ducts Intrahepat Summary Stage 2018 Chapter: Intrahepatic Bile Ducts

Applicable SSDIs

• NAACCR # 3835: Fibrosis Score • NAACCR # 3917: Primary Sclerosing Cholangitis • NAACCR # 3935: Tumor Growth Pattern

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 23: Intrahepatic Bile Ducts

Histology AJCC ID Description 8013, 8041, 8148, 8160-8161, 8180, 8246, 8470, 8503, 8980 23 Intrahepatic Bile Ducts 8000-8012, 8014-8040, 8042-8147, 8149-8158, 8162-8175, 8190- XX Other Intrahepatic 8245, 8247-8463, 8471-8502, 8504-8700, 8720-8790, 9700-9701 Bile Ducts

41 | Page Version 1.7 Schema ID 00241: Gallbladder

Primary Site(s)/Histology(ies) Primary Site Histology C239 8000-8700, 8720-8790, 9700-9701

AJCC Chapter 24: Gallbladder EOD Schema: Gallbladder Summary Stage 2018 Chapter: Gallbladder

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 24: Gallbladder

Histology AJCC ID Description 8000, 8010, 8013, 8020, 8041, 8070, 8140, 8144, 8148, 8160, 8244, 8246, 24 Gallbladder 8255, 8310, 8470, 8480-8481, 8490, 8503, 8560 8001-8005, 8011-8012, 8014-8015, 8021-8040, 8042-8060, 8071-8131, XX Other 8141-8143, 8145-8147, 8149-8158, 8161-8243, 8245, 8247-8254, 8256- Gallbladder 8300, 8311-8463, 8471-8474, 8482, 8500-8502, 8504-8552, 8561-8700, (Cystic Duct) 8720-8790, 9700-9701

42 | Page Version 1.7 Schema ID 00242: Cystic Duct

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C240 8000-8700, 8720-8790, 9700-9701 3

AJCC Chapter 24: Gallbladder EOD Schema: Cystic Duct Summary Stage 2018 Chapter: Extrahepatic Bile Ducts

Applicable SSDIs

• NAACCR # 3926: Schema Discriminator 1 (BileDuctsDistal/BileDuctsPerihilar/ CysticDuct)

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 24: Gallbladder

43 | Page Version 1.7 Schema ID 00250: Bile Ducts Perihilar

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C240 8000-8700, 8720-8790, 9700-9701 1, 5, 6, 9

AJCC Chapter 25: Perihilar Bile Ducts EOD Schema: Bile Ducts Perihilar Summary Stage 2018 Chapter: Extrahepatic Bile Ducts

Applicable SSDIs

• NAACCR # 3917: Primary Sclerosing Cholangitis • NAACCR # 3926: Schema Discriminator 1 (BileDuctsDistal/BileDuctsPerihilar/ CysticDuct)

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 25: Perihilar Bile Ducts

Histology AJCC ID Description 8010, 8013, 8020, 8041, 8070, 8140, 8144, 8148, 8246, 8310, 8470, 8480, 25 Perihilar Bile 8490, 8503, 8560 Ducts 8000-8005, 8011-8012, 8014-8015, 8021-8040, 8042-8060, 8071-8131, XX Other Perihilar 8141-8143, 8145-8147, 8149-8245, 8247-8300, 8311-8463, 8471-8474, Bile Ducts 8481-8482, 8500-8502, 8504-8552, 8561-8700, 8720-8790, 9700-9701

44 | Page Version 1.7 Schema ID 00260: Bile Duct Distal

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C240 8000-8700, 8720-8790, 9700-9701, 4,7

AJCC Chapter 26: Distal Bile Ducts EOD Schema: Bile Duct Distal Summary Stage 2018 Chapter: Extrahepatic Bile Ducts

Applicable SSDIs

• NAACCR # 3926: Schema Discriminator 1 (BileDuctsDistal/BileDuctsPerihilar/ CysticDuct)

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 26: Distal Bile Duct

Histology AJCC ID Description 8000, 8010, 8013, 8020, 8041, 8070, 8140, 8144, 8148, 8160, 8162, 8244, 26 Distal Bile 8246, 8310, 8470, 8480, 8490, 8500, 8503, 8560 Duct 8001-8005, 8011-8012, 8014-8015, 8021-8040, 8042-8060, 8071-8131, XX Other Distal 8141-8143, 8145-8147, 8149-8158, 8161, 8163-8243, 8245, 8247-8300, Bile Duct 8311-8463, 8471-8474, 8481-8482, 8501-8502, 8504-8552, 8561-8700, 8720-8790, 9700-9701

45 | Page Version 1.7 Schema ID 00270: Ampulla of Vater

Primary Site(s)/Histology(ies) Primary Site Histology C241 8000-8149, 8154, 8157, 8160-8231, 8243-8248, 8250-8682, 8690-8700, 8720-8790, 9700-9701

AJCC Chapter 27: Ampulla of Vater EOD Schema: Ampulla of Vater Summary Stage 2018 Chapter: Ampulla of Vater

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 27: Ampulla of Vater

Histology AJCC ID Description 8000, 8010, 8013, 8020, 8035, 8041, 8070, 8140, 8144, 8160, 8163, 8244, 27 Ampulla of 8246, 8255, 8260, 8310, 8480, 8490, 8560, 8576 Vater 8001-8005, 8011-8012, 8014-8015, 8021-8034, 8040, 8042-8060, 8071-8131, XX Other 8141-8143, 8145-8149, 8154, 8157, 8161-8162, 8170-8231, 8243, 8245, Ampulla of 8247-8248, 8250-8254, 8256-8257, 8261-8300, 8311-8474, 8481-8482, 8500- Vater 8552, 8561-8575, 8580-8682, 8690-8700, 8720-8790, 9700-9701

46 | Page Version 1.7 Schema ID 00278: Biliary Other

Primary Site(s)/Histology(ies) Primary Site Histology C248-C249 8000-8700, 8720-8790, 9700-9701

AJCC Chapter: None EOD Schema: Biliary Other Summary Stage 2018 Chapter: Biliary Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

47 | Page Version 1.7 Schema ID 00280: Pancreas

Primary Site(s)/Histology(ies) Primary Site Histology C250-C254, 8000-8149, 8154, 8157, 8160-8231, 8243-8248, 8250-8682, 8690-8700, 8720-8790, C257-C259 8971, 9700-9701

AJCC Chapter 28: Pancreas EOD Schema: Pancreas Summary Stage 2018 Chapter: Pancreas (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 28: Pancreas

Primary Site Histology AJCC ID Description C250-C253, 8000, 8010, 8013, 8020, 8035, 8041, 8140, 8148, 8154, 8246, 28 Exocrine C257-C259 8441, 8452-8453, 8470, 8480-8481, 8490, 8500, 8503, 8510, Pancreas 8550-8552, 8560, 8576, 8971 C254 8000, 8010, 8013, 8020, 8035, 8041, 8140, 8148, 8154, 8246, XX Other 8441, 8452-8453, 8470, 8480-8481, 8490, 8500, 8503, 8510, Exocrine 8550-8552, 8560, 8576, 8971 Pancreas C250-C254, 8001-8005, 8011-8012, 8014-8015, 8021-8034, 8040, 8042- XX Other C257-C259 8131, 8141-8147, 8149, 8157, 8160-8231, 8243-8245, 8247- Exocrine 8248, 8250-8440, 8442-8451, 8454-8463, 8471-8474, 8482, Pancreas 8501-8502, 8504-8509, 8512-8543, 8561-8575, 8580-8682, 8690-8700, 8720-8790, 9700-9701

48 | Page Version 1.7 Schema ID 00288: Digestive Other

Primary Site(s)/Histology(ies) Primary Site Histology C260, C268-C269 8000-8700, 8720-8790, 9700-9701

AJCC Chapter: None EOD Schema: Digestive Other Summary Stage 2018 Chapter: Digestive Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

49 | Page Version 1.7 Schema ID 00290: NET Stomach

Primary Site(s)/Histology(ies) Primary Site Histology C160-C166, C168-C169 8150-8153, 8155-8156, 8158, 8240-8242, 8249, 8683

AJCC Chapter 29: NET Stomach EOD Schema: NET Stomach Summary Stage 2018 Chapter: Stomach (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 07:

Code Grade Description 1 G1: Mitotic count (per 10 HPF) less than 2 AND Ki-67 index (%) less than 3 2 G2: Mitotic count (per 10 HPF) equal 2-20 OR Ki-67 index (%) equal 3-20 3 G3: Mitotic count (per 10 HPF) greater than 20 OR Ki-67 index (%) greater than 20 A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed (GX); Unknown

AJCC ID 29: NET Stomach

Histology Behavior AJCC ID Description 8240, 8249 3 29 Neuroendocrine Tumors of the Stomach 8240, 8249 2 XX Other Neuroendocrine Tumors of the Stomach 8150-8153, 8155-8156, 8158, 8241- Stomach

50 | Page Version 1.7 Schema ID 00301: NET Duodenum

Primary Site(s)/Histology(ies) Primary Site Histology C170 8150-8153, 8155-8156, 8158, 8240-8242, 8249, 8683

AJCC Chapter 30: Neuroendocrine Tumors of the Duodenum and Ampulla of Vater EOD Schema: NET Duodenum Summary Stage 2018 Chapter: Small Intestine (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 07:

AJCC ID 30: Neuroendocrine Tumors of the Duodenum and Ampulla of Vater

Histology Behavior AJCC ID Description 8153, 8156, 8158, 8240, 3 30 Neuroendocrine Tumors of the Duodenum and 8249, 8683 Ampulla of Vater 8153, 8156, 8158, 8240, 2 XX Other Neuroendocrine Tumors of the Duodenum 8249, 8683 and Ampulla of Vater 8150-8152, 8155, 8241- and Ampulla of Vater

51 | Page Version 1.7 Schema ID 00302: NET Ampulla of Vater

Primary Site(s)/Histology(ies) Primary Site Histology C241 8150-8153, 8155-8156, 8158, 8240-8242, 8249, 8683

AJCC Chapter 30: Neuroendocrine Tumors of the Duodenum and Ampulla of Vater EOD Schema: NET Ampulla of Vater Summary Stage 2018 Chapter: Ampulla of Vater (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 07:

AJCC ID 30: Neuroendocrine Tumors of the Duodenum and Ampulla of Vater

52 | Page Version 1.7 Schema ID 00310: NET Jejunum and Ileum

Primary Site(s)/Histology(ies) Primary Site Histology C171-C173, C178-C179 8150-8153, 8155-8156, 8158, 8240-8242, 8249, 8683

AJCC Chapter 31: Neuroendocrine Tumors of the Jejunum and Ileum EOD Schema: NET Jejunum and Ileum Summary Stage 2018 Chapter: Small Intestine (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 07:

AJCC ID 31: Neuroendocrine Tumors of the Jejunum and Ileum

Primary Site Histology Behavior AJCC ID Description C171-C172 8240, 8249 3 31 Neuroendocrine Tumors of the Jejunum and Ileum C171-C172 8240, 8249 2 XX Other Neuroendocrine Tumors of the Jejunum and Ileum C173, C178- 8240, 8249 the Jejunum and Ileum C171-C173, 8150-8153, 8155-8156, the Jejunum and Ileum

53 | Page Version 1.7 Schema ID 00320: NET Appendix

Primary Site(s)/Histology(ies) Primary Site Histology C181 8150-8153, 8155-8156, 8158, 8240-8242, 8249, 8683

AJCC Chapter 32: Neuroendocrine Tumors of the Appendix EOD Schema: NET Appendix Summary Stage 2018 Chapter: Appendix (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 07:

AJCC ID 32: Neuroendocrine Tumors of the Appendix

Histology Behavior AJCC ID Description 8240, 8249 3 32 Neuroendocrine Tumors of the Appendix 8240, 8249 2 XX Other Neuroendocrine Tumors of the Appendix 8150-8153, 8155-8156, 8158, 8241- Appendix

54 | Page Version 1.7 Schema ID 00330: NET Colon and Rectum

Primary Site(s)/Histology(ies) Primary Site Histology C180, C182-C189, C199, C209 8150-8153, 8155-8156, 8158, 8240-8242, 8249, 8683

AJCC Chapter 33: Neuroendocrine Tumors of the Colon and Rectum EOD Schema: NET Colon and Rectum Summary Stage 2018 Chapter: Colon and Rectum (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 07:

AJCC ID 33: Neuroendocrine Tumors of the Colon and Rectum

Histology Behavior AJCC ID Description 8240, 8249 3 33 Neuroendocrine Tumors of the Colon and Rectum 8240, 8249 2 XX Other Neuroendocrine Tumors of the Colon and Rectum 8150-8153, 8155-8156, 8158, Colon and Rectum

55 | Page Version 1.7 Schema ID 00340: NET Pancreas

Primary Site(s)/Histology(ies) Primary Site Histology C250-C254, C257-C259 8150-8153, 8155-8156, 8158, 8240-8242, 8249, 8683

AJCC Chapter 34: Neuroendocrine Tumors of the Pancreas EOD Schema: NET Pancreas Summary Stage 2018 Chapter: Pancreas (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 07:

AJCC ID 34: Neuroendocrine Tumors of the Pancreas

Primary Site Histology Behavior AJCC ID Description C250-C252, C254, 8150-8153, 8155-8156, 3 34 Neuroendocrine Tumors of the C257-C259 8158, 8240, 8249 Pancreas C250-C252, C254, 8150-8153, 8155-8156, 2 XX Other Neuroendocrine Tumors C257-C259 8158, 8240, 8249 of the Pancreas C253 8150-8153, 8155-8156, of the Pancreas C250-C254, C254, 8241-8242, 8683 of the Pancreas

56 | Page Version 1.7 Schema ID 00350: Thymus

Primary Site(s)/Histology(ies) Primary Site Histology C379 8000-8700, 8720-8790, 9700-9701

AJCC Chapter 35: Thymus EOD Schema: Thymus Summary Stage 2018 Chapter: Thymus

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 35: Thymus

Histology Behavior AJCC ID Description 8013, 8020, 8023, 8033, 8041, 8045, 8070, 8082, 8123, 8140, 8200, 3 35 Thymus 8240, 8249, 8260, 8310, 8430, 8480, 8560, 8576, 8580-8586 8013, 8020, 8023, 8033, 8041, 8045, 8070, 8082, 8123, 8140, 8200, 2 XX Other 8240, 8249, 8260, 8310, 8430, 8480, 8560, 8576, 8580-8586 Thymus 8000-8012, 8014-8015, 8021-8022, 8030-8032, 8034-8040, 8042- Thymus 8201-8231, 8241-8248, 8250-8257, 8261-8300, 8311-8420, 8440- 8474, 8481-8552, 8561-8575, 8587-8700, 8720-8790, 9700-9701

57 | Page Version 1.7 Schema ID 00358: Trachea

Primary Site(s)/Histology(ies) Primary Site Histology C339 8000-8700, 8720-8790, 9700-9701

AJCC Chapter: None EOD Schema: Trachea Summary Stage 2018 Chapter: Trachea

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

58 | Page Version 1.7 Schema ID 00360: Lung

Primary Site(s)/Histology(ies) Primary Site Histology C340-C343, C348-C349 8000-8700, 8720-8790, 8972, 8980, 9700-9701

AJCC Chapter 36: Lung EOD Schema: Lung Summary Stage 2018 Chapter: Lung

Applicable SSDIs

• NAACCR # 3929: Separate Tumor Nodules • NAACCR # 3937: Visceral and Parietal Pleural Invasion

Grade Table 02:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 4 G4: Undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 36: Lung

Histology AJCC ID Description 8000, 8010, 8012-8013, 8022-8023, 8031-8033, 8040-8042, 8045, 8070-8072, 36 Lung 8082-8083, 8140, 8144, 8200, 8230, 8240, 8246, 8249-8250, 8252-8257, 8260, 8265, 8333, 8430, 8480-8481, 8551, 8560, 8562, 8972, 8980 8001-8005, 8011, 8014-8021, 8030, 8034-8035, 8043-8044, 8046-8060, 8073- XX Other Lung 8081, 8084-8131, 8141-8143, 8145-8191, 8201-8221, 8231, 8241-8245, 8247- 8248, 8251, 8261-8264, 8270-8332, 8334-8420, 8440-8474, 8482-8550, 8552, 8561, 8570-8700, 8720-8790, 9700-9701

59 | Page Version 1.7 Schema ID 00370: Pleural Mesothelioma

Primary Site(s)/Histology(ies) Primary Site Histology C340-C349, C384 9050-9055

AJCC Chapter 37: Malignant Pleural Mesothelioma EOD Schema: Pleural Mesothelioma Summary Stage 2018 Chapter: Pleural Mesothelioma

Applicable SSDIs

• NAACCR # 3913: Pleural Effusion

Grade Table 02:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 4 G4: Undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 37: Malignant Pleural Mesothelioma

Primary Site Histology AJCC ID Description C384 9050-9053 37 Malignant Pleural Mesothelioma C340-C349 9050-9055 XX Other Malignant Pleural Mesothelioma C384 9054-9055 XX Other Malignant Pleural Mesothelioma

60 | Page Version 1.7 Schema ID 00378: Respiratory Other

Primary Site(s)/Histology(ies) Primary Site Histology C390, C398-C399 8000-8700, 8720-8790, 9700-9701

AJCC Chapter: None EOD Schema: Respiratory Other Summary Stage 2018 Chapter: Respiratory Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

61 | Page Version 1.7 Schema ID 00381: Bone Appendicular Skeleton

Primary Site(s)/Histology(ies) Primary Site Histology C400-C403, C408-C411, C413, C418-C419 8000-8934, 8940-9137, 9141-9582, 9700-9701

AJCC Chapter 38: Bone EOD Schema: Bone Appendicular Skeleton Summary Stage 2018 Chapter: Bone

Applicable SSDIs

• NAACCR # 3908: Percent Necrosis Post Neoadjuvant

Grade Table 08:

Code Grade Description 1 G1: Well differentiated, low grade 2 G2: Moderately differentiated, high grade 3 G3: Poorly differentiated, high grade H Stated as “high grade” only 9 Grade cannot be assessed (GX); Unknown

AJCC ID 38.1: Bone: Appendicular Skeleton, Trunk, Skull and Facial Bones

Histology AJCC ID Description 8800-8801, 8804, 8810, 8815, 8830, 8850, 8890, 8900, 9040, 9120, 38.1 Bone: Appendicular 9133, 9180-9185, 9187, 9192-9194, 9220-9221, 9231, 9240, 9242- Skeleton, Trunk, Skull 9243, 9250, 9261, 9364, 9370-9372, 9540 and Facial Bones 8000-8790, 8802-8803, 8805-8806, 8811-8814, 8820-8827, 8831- XX Other Bone: 8842, 8851-8881, 8891-8898, 8901-8934, 8940-9030, 9041-9110, Appendicular Skeleton 9121-9132, 9135-9137, 9141-9175, 9186, 9191, 9195, 9200-9210, 9230, 9241, 9251-9260, 9262-9363, 9365, 9373-9539, 9541-9582, 9700-9701

62 | Page Version 1.7 Schema ID 00382: Bone Spine

Primary Site(s)/Histology(ies) Primary Site Histology C412 8000-8934, 8940-9137, 9141-9582, 9700-9701

AJCC Chapter 38: Bone EOD Schema: Bone Spine Summary Stage 2018 Chapter: Bone

Applicable SSDIs

• NAACCR # 3908: Percent Necrosis Post Neoadjuvant

Grade Table 08:

AJCC ID 38.2: Bone: Spine

Histology AJCC ID Description 8800-8801, 8804, 8810, 8815, 8830, 8850, 8890, 8900, 9040, 9120, 9133, 38.2 Bone: Spine 9180-9185, 9187, 9192-9194, 9220-9221, 9231, 9240, 9242-9243, 9250, 9261, 9364, 9370-9372, 9540 8000-8790, 8802-8803, 8805-8806, 8811-8814, 8820-8827, 8831-8842, 8851- XX Other Bone: 8881, 8891-8898, 8901-8934, 8940-9030, 9041-9110, 9121-9132, 9135-9137, Spine 9141-9175, 9186, 9191, 9195, 9200-9210, 9230, 9241, 9251-9260, 9262-9363, 9365, 9373-9539, 9541-9582, 9700-9701

63 | Page Version 1.7 Schema ID 00383: Bone Pelvis

Primary Site(s)/Histology(ies) Primary Site Histology C414 8000-8934, 8940-9137, 9141-9582, 9700-9701

AJCC Chapter 38: Bone EOD Schema: Bone Pelvis Summary Stage 2018 Chapter: Bone

Applicable SSDIs

• NAACCR # 3908: Percent Necrosis Post Neoadjuvant

Grade Table 08:

AJCC ID 38.3: Bone: Pelvis

Histology AJCC ID Description 8800-8801, 8804, 8810, 8815, 8830, 8850, 8890, 8900, 9040, 9120, 9133, 38.3 Bone: Pelvis 9180-9185, 9187, 9192-9194, 9220-9221, 9231, 9240, 9242-9243, 9250, 9261, 9364, 9370-9372, 9540 8000-8790, 8802-8803, 8805-8806, 8811-8814, 8820-8827, 8831-8842, 8851- XX Other Bone: 8881, 8891-8898, 8901-8934, 8940-9030, 9041-9110, 9121-9132, 9135-9137, Pelvis 9141-9175, 9186, 9191, 9195, 9200-9210, 9230, 9241, 9251-9260, 9262-9363, 9365, 9373-9539, 9541-9582, 9700-9701

64 | Page Version 1.7 Schema ID 00400: Soft Tissue Head and Neck

Primary Site(s)/Histology(ies) Primary Site Histology Behavior C000-C002, C006 8710-8714, 8800-8803, 8810-8905, 8912, 8921, 8932-8934, 8941- 9141-9230, 9240-9580, 9582 C003-C005, C008-C009, 8710-8714, 8800-8803, 8810-8905, 8912, 8921, 8932-8934, 8940- C058-C069 9141-9230, 9240-9580, 9582 C019, C024, C051-C052, 8710-8714, 8800-8803, 8810-8905, 8912, 8921, 8932-8934, 8940- C158, C301, C312-C329, 9240-9580, 9582 C739, C750, C754-C759 C079-C089 8710-8714, 8800-8803, 8810-8905, 8912, 8921, 8932-8934, 8940, 9110, 9121-9137, 9141-9230, 9240-9580, 9582 C300, C310-C311 8710-8714, 8800-8803, 8810-8905, 8912, 8921, 8932-8934, 8940, 9137, 9141-9230, 9240-9580, 9582 C470, C490 8000-8803, 8810-8905, 8912, 8921, 8932-8934, 8940-8990, 9000- 9582, 9700-9701 C722, C724-C725, C751-C753 8710-8714, 8800-8803, 8810-8898, 8901-8905, 8912, 8921, 8932- 3 8934, 8940-8990, 9000-9016, 9030-9043, 9045-9063, 9065, 9072- 9073, 9081-9083, 9086-9091, 9101-9110, 9121-9137, 9141-9210, 9221-9230, 9240-9361, 9363-9373, 9540-9580, 9582

AJCC Chapter 40: Soft tissue sarcoma of the Head and Neck EOD Schema: Soft Tissue Head and Neck Summary Stage 2018 Chapter: Soft Tissue

Applicable SSDIs

• NAACCR # 3815: Bone Invasion

Grade Table 09:

Code Grade Description 1 G1: Sum of differentiation score, mitotic count score and necrosis score equals 2 or 3 2 G2: Sum of differentiation score, mitotic count score and necrosis score of 4 or 5 3 G3: Sum of differentiation score, mitotic count score and necrosis score of 6, 7, or 8 A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed (GX); Unknown

65 | Page Version 1.7 AJCC ID 40: Soft tissue sarcoma of the Head and Neck

Primary Site Histology AJCC ID Description C000-C148, C150, 8711, 8800-8802, 8810-8811, 8815, 8825, 8832- 40 Soft Tissue C153, C158, C300- 8833, 8840, 8850, 8852, 8854, 8858, 8890, 8901, Sarcoma of the C329, C470, C490, 8912, 9040-9041, 9043, 9133, 9136, 9180, 9251, Head and Neck C722, C724-C725, 9364, 9540, 9542, 9561, 9580 C739, C750-C755, C758-C759 C470, C490 8000-8700, 8720-8790, 9700-9701 XX Other Soft Tissue Sarcoma of the Head and Neck C000-C148, C150, 8710, 8712-8714, 8803, 8812-8814, 8820-8824, XX Other Soft C153, C158, C300- 8826-8831, 8834-8836, 8841-8842, 8851, 8853, Tissue Sarcoma C329, C470, C490 8855-8857, 8860-8881, 8891-8898, 8900, 8902- of the Head and 8905, 8921, 8932-8934, 8950-8973, 8975, 8981, Neck 8983-8990, 9000-9016, 9030, 9042, 9045-9110, 9121-9132, 9135, 9137, 9141-9175, 9181-9230, 9240-9250, 9252-9363, 9365-9539, 9541, 9550- 9560, 9562-9571, 9582 C003-C005, C008- 8940 XX Other Soft C148, C150, C153, Tissue Sarcoma C158, C300-C329, of the Head and C470, C490 Neck C000-C069, C090- 8941 XX Other Soft C148, C150, C153, Tissue Sarcoma C158, C301, C312- of the Head and C329, C470, C490 Neck C000-C069, C090- 8974, 8980 XX Other Soft C148, C150, C153, Tissue Sarcoma C158, C300-C329, of the Head and C470, C490 Neck C019, C024, C051- 8982 XX Other Soft C052, C090-C148, Tissue Sarcoma C150, C153, C158, of the Head and C301, C312-C329, Neck C470, C490 C722, C724-C725, 8710, 8712-8714, 8803, 8812-8814, 8820-8824, XX Other Soft C739, C750-C755, 8826-8831, 8834-8836, 8841-8842, 8851, 8853, Tissue Sarcoma C758-C759 8855-8857, 8860-8881, 8891-8898, 8902-8905, of the Head and 8921, 8932-8934, 8940-8990, 9000-9016, 9030, Neck 9042, 9045-9063, 9065, 9072-9073, 9081-9083, 9086-9091, 9101-9110, 9121-9132, 9135, 9137, 9141-9175, 9181-9210, 9221-9230, 9240-9250, 9252-9361, 9363, 9365-9373, 9541, 9550-9560, 9562-9571, 9582 C739, C750, C754- 8900, 9064, 9070-9071, 9080, 9084-9085, 9100, XX Other Soft C755, C758-C759 9220, 9362, 9380-9539 Tissue Sarcoma of the Head and Neck

66 | Page Version 1.7 Schema ID 00410: Soft Tissue Trunk and Extremities

Primary Site(s)/Histology(ies) Primary Site Histology C471-C472, C476, C478-C479, 8000-8803, 8810-8921, 8932-8934, 8940-8990, 9000-9016, 9030- C491-C492, C496, C498-C499 9043, 9045-9137, 9141-9230, 9240-9580, 9582, 9700-9701 C500-C506, C508-C509 8710-8714, 8800-8803, 8810-8921, 8932-8934, 8940-8981, 8990, 9000-9016, 9030-9043, 9045-9137, 9141-9230, 9240-9580, 9582

AJCC Chapter 41: Soft tissue sarcoma of the Trunk and Extremities EOD Schema: Soft Tissue Trunk and Extremities Summary Stage 2018 Chapter: Soft Tissue

Applicable SSDIs

• NAACCR # 3815: Bone Invasion

Grade Table 10:

AJCC ID 41: Soft tissue sarcoma of the Trunk and Extremities

Primary Site Histology AJCC ID Description C471-C472, C476, 8711, 8800-8802, 8810-8811, 8815, 8825, 8832- 41 Soft Tissue C478-C479, C491-C492, 8833, 8840, 8850, 8852, 8854, 8858, 8890, Sarcoma of the C496, C498-C499, 8901, 8910, 8912, 8920, 9040-9041, 9043, Trunk and C500-C509 9120, 9133, 9136, 9180, 9251, 9364, 9540, Extremities 9542, 9561, 9580 C471-C472, C476, 8000-8700, 8720-8790, 8982-8983, 9700-9701 XX Other Soft Tissue C478-C479, C491-C492, Sarcoma of the C496, C498-C499 Trunk and Extremities C471-C472, C476, 8710, 8712-8714, 8803, 8812-8814, 8820-8824, XX Other Soft Tissue C478-C479, C491-C492, 8826-8831, 8834-8836, 8841-8842, 8851, 8853, Sarcoma of the C496, C498-C499, 8855-8857, 8860-8881, 8891-8900, 8902-8905, Trunk and C500-C509 8921, 8932-8934, 8940-8981, 8990, 9000-9016, Extremities 9030, 9042, 9045-9110, 9121-9132, 9135, 9137, 9141-9175, 9181-9230, 9240-9250, 9252-9363, 9365-9539, 9541, 9550-9560, 9562-9571, 9582

67 | Page Version 1.7 Schema ID 00421: Soft Tissue Abdomen and Thoracic

Primary Site(s)/Histology(ies) Primary Site Histology C151-C152, C154-C155, C159, 8710-8714, 8800-8803, 8810-8921, 8932-8934, 8940-8990, C160-C220, C239-C249, C260-C269, 9000-9016, 9030-9043, 9045-9137, 9141-9230, 9240-9580, C339, C379, C600-C619, C630-C689 9582 C221 8710-8714, 8800-8803, 8810-8921, 8932-8934, 8940-8975, 8981-8990, 9000-9016, 9030-9043, 9045-9137, 9141-9230, 9240-9580, 9582 C250-C259 8710-8714, 8800-8803, 8810-8921, 8932-8934, 8940-8970, 8972-8990, 9000-9016, 9030-9043, 9045-9137, 9141-9230, 9240-9580, 9582 C340-C349 8710-8714, 8800-8803, 8810-8921, 8932-8934, 8940-8971, 8973-8975, 8981-8990, 9000-9016, 9030-9043, 9045, 9054- 9137, 9141-9230, 9240-9580, 9582 C473-C475, C493-C495 8000-8803, 8810-8921, 8932-8934, 8940-8990, 9000-9016, 9030-9043, 9045-9137, 9141-9230, 9240-9580, 9582, 9700- 9701 C510-C519 8710-8714, 8800-8803, 8810-8921, 8932-8934, 8940-8990, 9000-9016, 9030-9043, 9045-9070, 9072-9137, 9141-9230, 9240-9580, 9582 C529 8710-8714, 8800-8803, 8810-8921, 8932, 8934, 8940-8975, 8981-8990, 9000-9016, 9030-9043, 9045-9070, 9072-9105, 9120-9137, 9141-9230, 9240-9580, 9582 C530-C539 8710-8714, 8800-8803, 8810-8921, 8932, 8934, 8940-8975, 8981-8990, 9000-9016, 9030-9043, 9045-9105, 9120-9137, 9141-9230, 9240-9580, 9582 C589 8710-8714, 8800-8803, 8810-8921, 8932-8934, 8940-8990, 9000-9016, 9030-9043, 9045-9091, 9110-9137, 9141-9230, 9240-9580, 9582 C620-C629 8710-8714, 8800-8803, 8810-8921, 8932-8934, 8940-8990, 9000-9016, 9030-9043, 9045-9060, 9062-9063, 9072-9073, 9082-9083, 9086-9091, 9102-9103, 9110-9137, 9141-9230, 9240-9580, 9582

AJCC Chapter 42: Soft tissue sarcoma of the Abdomen and Thoracic Visceral Organs EOD Schema: Soft Tissue Abdomen and Thoracic Summary Stage 2018 Chapter: Soft Tissue

Applicable SSDIs

• NAACCR # 3815: Bone Invasion

Grade Table 09:

Code Grade Description 1 G1: Sum of differentiation score, mitotic count score and necrosis score equals 2 or 3 2 G2: Sum of differentiation score, mitotic count score and necrosis score of 4 or 5

68 | Page Version 1.7 Code Grade Description 3 G3: Sum of differentiation score, mitotic count score and necrosis score of 6, 7, or 8 A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed (GX); Unknown

AJCC ID 42: Soft tissue sarcoma of the Abdomen and Thoracic Visceral Organs

Primary Site Histology AJCC ID Description C151-C152, C154- 8711, 8800-8802, 8810-8811, 8815, 8825, 8832- 42 Soft Tissue C155, C159, C160- 8833, 8840, 8850, 8852, 8854, 8858, 8890, 8901, Sarcoma of the C269, C339, C340- 8910, 8912, 8920, 9040-9041, 9043, 9120, 9133, Abdomen and C379, C473-C475, 9136, 9180, 9251, 9364, 9540, 9542, 9561, 9580 Thoracic Visceral C493-C495, C510- Organs C539, C589, C600- C689 C473-C475, C493- 8000-8700, 8720-8790, 9700-9701 XX Other Soft Tissue C495 Sarcoma of the Abdomen and Thoracic Visceral Organs C151-C152, C154- 8710, 8712-8714, 8803, 8812-8814, 8820-8824, XX Other Soft Tissue C155, C159, C160- 8826-8831, 8834-8836, 8841-8842, 8851, 8853, Sarcoma of the C269, C339, C340- 8855-8857, 8860-8881, 8891-8900, 8902-8905, Abdomen and C379, C473-C475, 8921, 8932, 8934, 8940-8970, 8973-8975, 8981- Thoracic Visceral C493-C495, C510- 8983, 8990, 9000-9016, 9030, 9042, 9045, 9054- Organs C539, C589, C600- 9060, 9062-9063, 9072-9073, 9082-9083, 9086- C689 9091, 9121-9132, 9135, 9137, 9141-9175, 9181- 9230, 9240-9250, 9252-9363, 9365-9539, 9541, 9550-9560, 9562-9571, 9582 C151-C152, C154- 8933 XX Other Soft Tissue C155, C159, C160- Sarcoma of the C269, C339, C340- Abdomen and C379, C473-C475, Thoracic Visceral C493-C495, C510- Organs C519, C589, C600- C689 C151-C152, C154- 8971 XX Other Soft Tissue C155, C159, C160- Sarcoma of the C249, C260-C269, Abdomen and C339, C340-C379, Thoracic Visceral C473-C475, C493- Organs C495, C510-C539, C589, C600-C689 C151-C152, C154- 8972, 9050-9053 XX Other Soft Tissue C155, C159, C160- Sarcoma of the C269, C339, C379, Abdomen and C473-C475, C493- Thoracic Visceral Organs

69 | Page Version 1.7 Primary Site Histology AJCC ID Description C495, C510-C539, C589, C600-C689 C151-C152, C154- 8980 XX Other Soft Tissue C155, C159, C160- Sarcoma of the C220, C239-C269, Abdomen and C339, C379, C473- Thoracic Visceral C475, C493-C495, Organs C510-C519, C589, C600-C689 C151-C152, C154- 9061, 9064-9065, 9070, 9080-9081, 9084-9085 XX Other Soft Tissue C155, C159, C160- Sarcoma of the C269, C339, C340- Abdomen and C379, C473-C475, Thoracic Visceral C493-C495, C510- Organs C539, C589, C600- C619, C630-C689 C151-C152, C154- 9071 XX Other Soft Tissue C155, C159, C160- Sarcoma of the C269, C339, C340- Abdomen and C379, C473-C475, Thoracic Visceral C493-C495, C530- Organs C539, C589, C600- C619, C630-C689 C151-C152, C154- 9100-9101, 9104-9105 XX Other Soft Tissue C155, C159, C160- Sarcoma of the C269, C339, C340- Abdomen and C379, C473-C475, Thoracic Visceral C493-C495, C510- Organs C539, C600-C619, C630-C689 C151-C152, C154- 9102-9103 XX Other Soft Tissue C155, C159, C160- Sarcoma of the C269, C339, C340- Abdomen and C379, C473-C475, Thoracic Visceral C493-C495, C510- Organs C539, C600-C689 C151-C152, C154- 9110 XX Other Soft Tissue C155, C159, C160- Sarcoma of the C269, C339, C340- Abdomen and C379, C473-C475, Thoracic Visceral C493-C495, C510- Organs C519, C589, C600- C689

70 | Page Version 1.7 Schema ID 00422: Heart, Mediastinum, and Pleura

Primary Site(s)/Histology(ies) Primary Site Histology C380-C383, 8000-8803, 8810-8921, 8932-8934, 8940-8990, 9000-9016, 9030, 9040-9043, 9045- C388 9137, 9141-9230, 9240-9580, 9582, 9700-9701 C384 8000-8803, 8810-8921, 8932-8934, 8940-8990, 9000-9016, 9030, 9040-9043, 9045, 9054-9137, 9141-9230, 9240-9580, 9582, 9700-9701

AJCC Chapter 42: Soft tissue sarcoma of the Abdomen and Thoracic Visceral Organs EOD Schema: Heart, Mediastinum, and Pleura Summary Stage 2018 Chapter: Heart, Mediastinum, and Pleura

Applicable SSDIs

• NAACCR # 3815: Bone Invasion

Grade Table 09:

AJCC ID 42: Soft tissue sarcoma of the Abdomen and Thoracic Visceral Organs

Primary Site Histology AJCC ID Description C380-C384, 8711, 8800-8802, 8810-8811, 8815, 8825, 8832-8833, 42 Soft Tissue Sarcoma C388 8840, 8850, 8852, 8854, 8858, 8890, 8901, 8910, 8912, of the Abdomen 8920, 9040-9041, 9043, 9120, 9133, 9136, 9180, 9251, and Thoracic 9364, 9540, 9542, 9561, 9580 Visceral Organs C380-C384, 8000-8710, 8712-8790, 8803, 8812-8814, 8820-8824, XX Other Soft Tissue C388 8826-8831, 8834-8836, 8841-8842, 8851, 8853, 8855- Sarcoma of the 8857, 8860-8881, 8891-8900, 8902-8905, 8921, 8932- Abdomen and 8934, 8940-8990, 9000-9016, 9030, 9042, 9045, 9054- Thoracic Visceral 9110, 9121-9132, 9135, 9137, 9141-9175, 9181-9230, Organs 9240-9250, 9252-9363, 9365-9539, 9541, 9550-9560, 9562-9571, 9582, 9700-9701 C380-C383, 9050-9053 XX Other Soft Tissue C388 Sarcoma of the Abdomen and Thoracic Visceral Organs

71 | Page Version 1.7 Schema ID 00430: GIST

Primary Site(s)/Histology(ies) Primary Site Histology Behavior C000-C539, C571-C699, C739-C750, C754-C809 8935-8936 C700-C729, C751-C753 8935-8936 3

AJCC Chapter 43: Gastrointestinal Stromal Tumor EOD Schema: GIST Summary Stage 2018 Chapter: GIST

Applicable SSDIs

• NAACCR # 3865: KIT Gene Immunohistochemistry • NAACCR # 3926: Schema Discriminator 1 (Primary Peritoneum Tumor)

Grade Table 11:

Code Grade Description L Low: 5 or fewer mitoses per 5 square mm H High: Over 5 mitoses per 5 square mm A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 43.1: Gastrointestinal Stromal Tumor: Gastric and Omental AJCC ID 43.2: Gastrointestinal Stromal Tumor: Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal

Primary Site Histology Behavior Schema AJCC ID Description Discriminator 1 C150-C159, 8936 0, 1, 3 43.2 Gastrointestinal C170-C172, Stromal Tumor: Small C178-C209, Intestinal, Esophageal, C480, C482, Colorectal, Mesenteric, C488 and Peritoneal C160-C169 8936 0, 1, 3 43.1 Gastrointestinal Stromal Tumor: Gastric and Omental C173 8936 0, 1, 3, 2 XX Other Gastrointestinal Stromal Tumors C481 8936 0, 1, 3 2 43.1 Gastrointestinal Stromal Tumor: Gastric and Omental C481 8936 0, 1, 3 1, 9 43.2 Gastrointestinal Stromal Tumor: Small Intestinal, Esophageal,

72 | Page Version 1.7 Primary Site Histology Behavior Schema AJCC ID Description Discriminator 1 Colorectal, Mesenteric, and Peritoneal C150-C159, 8936 2 XX Other Gastrointestinal C160-C169, Stromal Tumors C170-C172, C178-C209, C480, C482, C488 C481 8936 2 1, 2, 9 XX Other Gastrointestinal Stromal Tumors C150-C209, 8935 XX Other Gastrointestinal C480-C482, value> Stromal Tumors C488 C481 8935 Stromal Tumors C000-C148, 8935, XX Other Gastrointestinal C210-C479, 8936 value> Stromal Tumors C490-C539, C571-C699, C739-C750, C754-C809 C700-C729, 8935, 3 XX Other Gastrointestinal C751-C753 8936 Stromal Tumors C000-C480, 8935, is not C481, C571-C699, Schema C739-C750, Discriminator C754-C809 1 should be blank C700-C729, 8935, 3 1, 2, 9 ERROR: Site C751-C753 8936 is not C481, Schema Discriminator 1 should be blank

73 | Page Version 1.7 Schema ID 00440: Retroperitoneum

Primary Site(s)/Histology(ies) Primary Site Histology Sex C480 8000-8803, 8810-8921, 8932-8934, 8940-8990, 9000-9016, 9030-9043, C481-C482, 8000-8700, 8720-8790, 8822, 8933, 8950, 8960, 8980, 9000, 9050, 9052, 1, 3, 4, C488 9060, 9070-9071, 9073, 9080, 9085, 9090-9091, 9100, 9110, 9700-9701 5, 9 C481-C482, 8710-8714, 8800-8803, 8810-8821, 8823-8921, 8932, 8934, 8940-8941, 9053-9055, 9061-9065, 9072, 9081-9084, 9086, 9101-9105, 9120-9137, 9141-9230, 9240-9580, 9582

AJCC Chapter 44: Soft tissue sarcoma of the Retroperitoneum EOD Schema: Retroperitoneum Summary Stage 2018 Chapter: Retroperitoneum

Applicable SSDIs

• NAACCR # 3815: Bone Invasion

Grade Table 10:

AJCC ID 44: Soft tissue sarcoma of the Retroperitoneum

Histology AJCC ID Description 8711, 8800-8802, 8810-8811, 8815, 8825, 8832-8833, 8840, 8850, 44 Soft Tissue Sarcoma of 8852, 8854, 8858, 8890, 8901, 8910, 8912, 8920, 9040-9041, 9043, the Retroperitoneum 9120, 9133, 9136, 9180, 9251, 9364, 9540, 9542, 9561, 9580 8000-8700, 8710, 8712-8714, 8720-8790, 8803, 8812-8814, 8820- XX Other Soft Tissue 8824, 8826-8831, 8834-8836, 8841-8842, 8851, 8853, 8855-8857, Sarcoma of the 8860-8881, 8891-8900, 8902-8905, 8921, 8932-8934, 8940-8990, Retroperitoneum 9000-9016, 9030, 9042, 9045-9110, 9121-9132, 9135, 9137, 9141- 9175, 9181-9230, 9240-9250, 9252-9363, 9365-9539, 9541, 9550- 9560, 9562-9571, 9582, 9700-9701

74 | Page Version 1.7 Schema ID 00450: Soft Tissue Other

Primary Site(s)/Histology(ies) Primary Site Histology Behavior Schema Sex Discriminator 1 C000-C148, C150, 8804-8806, 8910, 8920, 8930-8931, value> C329, C470, C490, C739, C750, C754- C759 C151-C152, C154- 8804-8806, 8930-8931, 8991, 9020, value> C269, C339-C388, C471-C479, C491- C499, C500-C509, C529, C589-C689 C390, C398-C399, 8710-8714, 8800-8934, 8940-9137, value> C440, C442-C449 8710-8714, 8800-8934, 8941-8981, value> C441 8710-8714, 8800-8934, 8950-8975, value> C480-C488 8804-8805, 8991, 9020, 9044, 9231, value> C480 8806, 8930-8931 value> C481-C482, C488 8806, 8930-8931 4, 5, 9 C510-C519 8804-8806, 8930-8931, 8991, 9044, value> C530-C539 8804, 8806, 8930-8931, 8991, 9020, value> C569, C570 8710-8714, 8800-8805, 8811-8814, value> 8891-8921, 8932, 8934, 8940-8941, 8951-8959, 8963-8975, 8981-8991, 9010-9045, 9051, 9053-9055, 9061- 9065, 9072, 9081-9084, 9086, 9101- 9105, 9120-9137, 9141-9582 C571-C579 8710-8714, 8800-8934, 8940-9137, value> C690-C696, C698- 8930-8931, 8991, 9020, 9180, 9231 value> C700-C721, C728- 8710-8714, 8800-8801, 8803-8806, 3 8891-8898, 8901-8934, 8940-9063, 9065, 9072-9073, 9081-9083, 9086- 9091, 9110, 9121-9132, 9135-9137, 9141-9175, 9181-9210, 9221-9361, 9363, 9365-9373, 9541-9582

75 | Page Version 1.7 Primary Site Histology Behavior Schema Sex Discriminator 1 C722, C724-C725, 8804-8806, 8910, 8920, 8930-8931, 3 C723 8930-8931, 8991, 9020, 9231 3 C740-C749, C761- 8710-8714, 8800-8934, 8940-9137, value> C770-C775, C778- C779, C809 C760 8710-8714, 8800-8934, 8940, 8950- value> C760 8941 value>

AJCC Chapter 45: Soft tissue sarcoma of Unusual Sites and Histologies EOD Schema: Soft Tissue Other Summary Stage 2018 Chapter: Soft Tissue

Applicable SSDIs

• NAACCR # 3815: Bone Invasion

Grade Table 09:

AJCC ID 45: Soft tissue sarcoma of Unusual Sites and Histologies

Primary Site Histology AJCC ID Description C000-C148, C150, 8804-8806, 8910, 8920, 8930-8931, 8991, 9020, 45 Soft Tissue C153, C158, C300- 9044, 9120, 9231, 9581 Sarcoma - C329, C470, C490, Unusual C739, C750, C754- Histologies and C759 Sites C151-C152, C154- 8804-8806, 8930-8931, 8991, 9020, 9044, 9231, 45 Soft Tissue C155, C159, C160- 9581 Sarcoma - C269, C339-C388, Unusual C471-C479, C491- Histologies and C499, C500-C509, Sites C529, C589-C689, C480-C488

76 | Page Version 1.7 Primary Site Histology AJCC ID Description C440, C442-C444 8710-8714, 8800-8934, 8941-8981, 8983-9137, XX Other Soft Tissue 9141-9582 Sarcoma - Unusual Histologies and Sites C510-C519 8804-8806, 8930-8931, 8991, 9044, 9231, 9581 45 Soft Tissue Sarcoma - Unusual Histologies and Sites C530-C539 8804, 8806, 8930-8931, 8991, 9020, 9044, 9231 45 Soft Tissue Sarcoma - Unusual Histologies and Sites C569, C570 8804-8805, 8901, 8910-8920, 8991, 9020, 9044, 45 Soft Tissue 9120, 9133, 9180, 9231, 9581 Sarcoma - Unusual Histologies and Sites C690-C696, C698- 8930-8931, 8991, 9020, 9180, 9231 45 Soft Tissue C699 Sarcoma - Unusual Histologies and Sites C700-C721, C728- 8804-8806, 8901, 8910-8920, 8930-8931, 8991, 45 Soft Tissue C729 9020, 9044, 9231, 9581 Sarcoma - Unusual Histologies and Sites C722, C724-C725, 8804-8806, 8910, 8920, 8930-8931, 8991, 9020, 45 Soft Tissue C751-C753 9044, 9231, 9581 Sarcoma - Unusual Histologies and Sites C723 8930-8931, 8991, 9020, 9231 45 Soft Tissue Sarcoma - Unusual Histologies and Sites C390, C398-C399, 8710-8714, 8800-8934, 8940-9137, 9141-9582 XX Other Soft Tissue C420-C424, C760- Sarcoma - C765, C767-C768, Unusual C770-C775, C778- Histologies and C779 Sites C441 8710-8714, 8800-8934, 8950-8975, 8981-9137, XX Other Soft Tissue 9141-9514, 9520-9582 Sarcoma - Unusual Histologies and Sites

77 | Page Version 1.7 Primary Site Histology AJCC ID Description C445-C449 8710-8714, 8800-8934, 8941-8981, 8983-9137, XX Other Soft Tissue 9141-9582 Sarcoma - Unusual Histologies and Sites C569, C570 8710-8714, 8800-8803, 8811-8814, 8820-8821, XX Other Soft Tissue 8823-8824, 8826-8881, 8891-8900, 8902-8905, Sarcoma - 8921, 8932, 8934, 8940-8941, 8951-8959, 8963- Unusual 8975, 8981-8990, 9010-9016, 9030-9043, 9045, Histologies and 9051, 9053-9055, 9061-9065, 9072, 9081-9084, Sites 9086, 9101-9105, 9121-9132, 9135-9137, 9141- 9175, 9181-9230, 9240-9580, 9582 C571-C579, C740- 8804-8806, 8815, 8901, 8910-8920, 8930-8931, 45 Soft Tissue C749, C809 8991, 9020, 9044, 9120, 9133, 9180, 9231, 9581 Sarcoma - Unusual Histologies and Sites C571-C579, C740- 8710-8714, 8800-8803, 8810-8814, 8820-8900, XX Other Soft Tissue C749, C809 8902-8905, 8921, 8932-8934, 8940-8990, 9000- Sarcoma - 9016, 9030-9043, 9045-9110, 9121-9132, 9135- Unusual 9137, 9141-9175, 9181-9230, 9240-9580, 9582 Histologies and Sites C700-C721, C728- 8710-8714, 8800-8801, 8803, 8811-8814, 8820- XX Other Soft Tissue C729 8842, 8851-8881, 8891-8898, 8902-8905, 8921, Sarcoma - 8932-8934, 8940-8990, 9000-9016, 9030-9043, Unusual 9045-9063, 9065, 9072-9073, 9081-9083, 9086- Histologies and 9091, 9110, 9121-9132, 9135-9137, 9141-9175, Sites 9181-9210, 9221-9230, 9240-9361, 9363, 9365- 9373, 9541-9580, 9582

78 | Page Version 1.7 Schema ID 00458: Kaposi Sarcoma

Primary Site(s)/Histology(ies) Primary Site Histology C000-C699, C739-C750, C754-C809 9140

AJCC Chapter 44: Soft tissue sarcoma of Unusual Sites and Histologies EOD Schema: Kaposi Sarcoma Summary Stage 2018 Chapter: Kaposi Sarcoma

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 09:

AJCC ID 45: Soft tissue sarcoma of Unusual Sites and Histologies

Primary Site AJCC ID Description C000-C388, C470-C539, C569-C695, C699, 45 Soft Tissue Sarcoma - Unusual Histologies C739-C749, C809 and Sites C390-C449, C540-C559, C696, C698, C750, XX Other Kaposi Sarcoma C754-C779

79 | Page Version 1.7 Schema ID 00460: Merkel Cell Skin

Primary Site(s)/Histology(ies) Primary Site Histology C000-C009, C440-C449, C510-C512, C518-C519, C600-C602, C608-C609, C632, 8041, 8190, 8247 C809 8190, 8247

AJCC Chapter 46: Merkel Cell Carcinoma EOD Schema: Merkel Cell Skin Summary Stage 2018 Chapter: Merkel Cell

Applicable SSDIs

• NAACCR # 3830: Extranodal Extension Clin (non-Head and Neck) • NAACCR # 3833: Extranodal Extension Path (non-Head and Neck) • NAACCR # 3880: LN Isolated Tumor Cells (ITC) • NAACCR # 3918: Profound Immune Suppression

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 46: Merkel Cell Skin

Histology AJCC ID Description 8041, 8190, 8247 46 Merkel Cell Carcinoma

80 | Page Version 1.7 Schema ID 00470: Melanoma Skin

Primary Site(s)/Histology(ies) Primary Site Histology C000-C002, C006, , C440-C449, C500, C510-C512, C518-C519, C600-C602, 8720-8790 C608-C609, C632

AJCC Chapter 47: Melanoma Skin EOD Schema: Melanoma Skin Summary Stage 2018 Chapter: Melanoma Skin

Applicable SSDIs

• NAACCR # 3817: Breslow Tumor Thickness • NAACCR # 3869: LDH Pretreatment Level • NAACCR # 3870: LDH Upper Limits of Normal • NAACCR # 3893: Mitotic Rate Melanoma • NAACCR # 3932: LDH Pretreatment Lab Value • NAACCR # 3936: Ulceration

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 47: Melanoma Skin

Histology AJCC ID Description 8720-8721, 8723, 8730, 8742-8745, 8761, 8770-8772, 8780 47 Melanoma of the Skin 8722, 8725-8728, 8740-8741, 8746-8760, 8762, 8773-8774, XX Other Melanoma of the 8790 Skin

81 | Page Version 1.7 Schema ID 00478: Skin Other

Primary Site(s)/Histology(ies) Primary Site Histology C445-C449 8000-8040, 8042-8180, 8191-8246, 8248- 8700, 8940, 8982

AJCC Chapter: None EOD Schema: Skin Other Summary Stage 2018 Chapter: Skin (except Eyelid)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

82 | Page Version 1.7 Schema ID 00480: Breast

Primary Site(s)/Histology(ies) Primary Site Histology C500-C506, C508-C509 8000-8700, 8982-8983, 9700-9701 C501-C506, C508-C509 8720-8790

AJCC Chapter 48: Breast EOD Schema: Breast Summary Stage 2018 Chapter: Breast

Applicable SSDIs

• NAACCR # 3826: Estrogen Receptor Percent Positive or Range • NAACCR # 3827: Estrogen Receptor Summary • NAACCR # 3828: Estrogen Receptor Total Allred Score • NAACCR # 3850: HER2 IHC Summary • NAACCR # 3851: HER2 ISH Dual Probe Copy Number • NAACCR # 3852: HER2 ISH Dual Probe Ratio • NAACCR # 3853: HER2 ISH Single Probe Copy Number • NAACCR # 3854: HER2 ISH Summary • NAACCR # 3855: HER2 Overall Summary • NAACCR # 3863: Ki-67 • NAACCR # 3882: LN Positive Axillary Level I-II • NAACCR # 3894: Multigene Signature Method • NAACCR # 3895: Multigene Signature Results • NAACCR # 3903: Oncotype Dx Recurrence Score-DCIS • NAACCR # 3904: Oncotype Dx Recurrence Score-Invasive • NAACCR # 3905: Oncotype Dx Risk Level-DCIS • NAACCR # 3906: Oncotype Dx Risk Level-Invasive • NAACCR # 3914: Progesterone Receptor Percent Positive or Range • NAACCR # 3915: Progesterone Receptor Summary • NAACCR # 3916: Progesterone Receptor Total Allred Score • NAACCR # 3922: Response to Neoadjuvant Therapy

Grade Table 12:

Code Grade Description 1 G1: Low combined histologic grade (favorable), SBR score of 3–5 points 2 G2: Intermediate combined histologic grade (moderately favorable); SBR score of 6–7 points 3 G3: High combined histologic grade (unfavorable); SBR score of 8–9 points L Nuclear Grade I (Low) (in situ only) M Nuclear Grade II (interMediate) (in situ only) H Nuclear Grade III (High) (in situ only) A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed (GX); Unknown

83 | Page Version 1.7 AJCC ID 48.1: Breast DCIS AJCC ID 48.2: Breast Invasive

Primary Site Histology Behavior AJCC ID Description C500-C506, 8000, 8010, 8022, 8032, 8035, 8041, 8070, 8140, 2 XX Other C508-C509 8200, 8211, 8246, 8255, 8290, 8314-8315, 8401, Breast 8410, 8430, 8480, 8502, 8509-8510, 8513, 8520- 8525, 8530, 8540-8541, 8550, 8570-8572, 8574- 8575, 8982-8983 C500-C506, 8201, 8500-8501, 8503-8504, 8507, 8543 2 48.1 Breast DCIS C508-C509 C500-C506, 8000, 8010, 8022, 8032, 8035, 8041, 8070, 8140, 3 48.2 Breast C508-C509 8200-8201, 8211, 8246, 8255, 8290, 8314-8315, Invasive 8401, 8410, 8430, 8480, 8500-8504, 8507, 8509- 8510, 8513, 8520-8525, 8530, 8540-8541, 8543, 8550, 8570-8572, 8574-8575, 8982-8983 C500-C506, 8001-8005, 8011-8021, 8023-8031, 8033-8034, Breast 8210, 8212-8245, 8247-8254, 8256-8281, 8300- 8313, 8316-8400, 8402-8409, 8413-8420, 8440- 8474, 8481-8490, 8505-8506, 8508, 8512, 8514- 8519, 8542, 8551-8562, 8573, 8576-8700, 9700- 9701 C501-C506, 8720-8790 Breast

84 | Page Version 1.7 Schema ID 00500: Vulva

Primary Site(s)/Histology(ies) Primary Site Histology C510-C512, C518-C519 8000-8040, 8042-8180, 8191-8246, 8248-8700, 9020, 9071

AJCC Chapter 50: Vulva EOD Schema: Vulva Summary Stage 2018 Chapter: Vulva

Applicable SSDIs

• NAACCR # 3836: FIGO Stage (Vulva) • NAACCR # 3871: LN Assessment Method Femoral-Inguinal • NAACCR # 3872: LN Assessment Method Para-aortic • NAACCR # 3873: LN Assessment Method Pelvic • NAACCR # 3881: LN Laterality • NAACCR # 3884: LN Status Femoral-Inguinal, Para-aortic, Pelvic

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 50: Vulva

Histology Behavior AJCC ID Description 8000, 8010, 8013, 8051, 8070-8072, 8076-8077, 8083, 8090, 8097, 3 50 Vulva 8120, 8140, 8200, 8500, 8542, 8560, 9020, 9071 8000, 8010, 8013, 8051, 8070-8072, 8076-8077, 8083, 8090, 8097, 2 XX Other 8120, 8140, 8200, 8500, 8542, 8560, 9020, 9071 Vulva 8001-8005, 8011-8012, 8014-8040, 8042-8050, 8052-8060, 8073- Vulva 8141-8180, 8191, 8201-8246, 8248-8490, 8501-8541, 8543-8552, 8561-8700

85 | Page Version 1.7 Schema ID 00510: Vagina

Primary Site(s)/Histology(ies) Primary Site Histology C529 8000-8700, 8720-8790, 8933, 8980, 9071, 9110, 9700-9701

AJCC Chapter 51: Vagina EOD Schema: Vagina Summary Stage 2018 Chapter: Vagina

Applicable SSDIs

• NAACCR # 3836: FIGO Stage (Vagina) • NAACCR # 3871: LN Assessment Method Femoral-Inguinal • NAACCR # 3872: LN Assessment Method Para-aortic • NAACCR # 3873: LN Assessment Method Pelvic • NAACCR # 3874: LN Distant Assessment Method • NAACCR # 3875: LN Distant: Mediastinal, Scalene • NAACCR # 3884: LN Status Femoral-Inguinal, Para-aortic, Pelvic

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 51: Vagina

Histology Behavior AJCC ID Description 8000, 8010, 8013, 8020, 8041, 8051-8052, 8070-8072, 8083, 8098, 3 51 Vagina 8140, 8246, 8260, 8310, 8380, 8480, 8560, 8693, 8933, 8980, 9071, 9110 8000, 8010, 8013, 8020, 8041, 8051-8052, 8070-8072, 8083, 8098, 2 XX Other 8140, 8246, 8260, 8310, 8380, 8480, 8560, 8693, 8933, 8980, Vagina 9071, 9110 8001-8005, 8011-8012, 8014-8015, 8021-8040, 8042-8050, 8053- Vagina 8261-8300, 8311-8375, 8381-8474, 8481-8552, 8561-8692, 8700, 8720-8790, 9700-9701

86 | Page Version 1.7 Schema ID 00520: Cervix

Primary Site(s)/Histology(ies) Primary Site Histology C530-C531, C538-C539 8000-8700, 8720-8790, 8805, 8933, 8980, 9110, 9581, 9700-9701

AJCC Chapter 52: Cervix EOD Schema: Cervix Summary Stage 2018 Chapter: Cervix

Applicable SSDIs

• NAACCR # 3836: FIGO Stage (Cervix) • NAACCR # 3871: LN Assessment Method Femoral-Inguinal • NAACCR # 3872: LN Assessment Method Para-aortic • NAACCR # 3873: LN Assessment Method Pelvic • NAACCR # 3874: LN Distant Assessment Method • NAACCR # 3875: LN Distant: Mediastinal, Scalene • NAACCR # 3884: LN Status Femoral-Inguinal, Para-aortic, Pelvic

Grade Table 01:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 52: Cervix

Histology Behavior AJCC ID Description 8000, 8010, 8013, 8015, 8020, 8041, 8051-8052, 8070-8072, 8076, 3 52 Cervix Uteri 8082-8083, 8098, 8120, 8140, 8144, 8200, 8240, 8249, 8263, 8310, 8323, 8380, 8384, 8441, 8480, 8482, 8490, 8560, 8574, 8720, 8805, 8933, 8980, 9110, 9581 8000, 8010, 8013, 8015, 8020, 8041, 8051-8052, 8070-8072, 8076, 2 XX Other Cervix 8082-8083, 8098, 8120, 8140, 8144, 8200, 8240, 8249, 8263, 8310, Uteri 8323, 8380, 8384, 8441, 8480, 8482, 8490, 8560, 8574, 8720, 8805, 8933, 8980, 9110, 9581 8001-8005, 8011-8012, 8014, 8021-8040, 8042-8050, 8053-8060, Uteri 8143, 8145-8191, 8201-8231, 8241-8248, 8250-8262, 8264-8300, 8311-8322, 8324-8375, 8381-8383, 8390-8440, 8442-8474, 8481, 8500-8552, 8561-8573, 8575-8700, 8721-8790, 9700-9701

87 | Page Version 1.7 Schema ID 00530: Corpus Carcinoma and Carcinosarcoma

Primary Site(s)/Histology(ies) Primary Site Histology C540-C543, C548-C549, C559 8000-8700, 8720-8790, 8950, 8980, 9700-9701

AJCC Chapter 53: Corpus Uteri - Carcinoma and Carcinosarcoma EOD Schema: Corpus Carcinoma and Carcinosarcoma Summary Stage 2018 Chapter: Corpus Carcinoma and Carcinosarcoma

Applicable SSDIs

• NAACCR # 3836: FIGO Stage (Corpus Carcinoma and Carcinosarcoma) • NAACCR # 3899: Number of Examined Para-Aortic Nodes • NAACCR # 3900: Number of Examined Pelvic Nodes • NAACCR # 3901: Number of Positive Para-Aortic Nodes • NAACCR # 3902: Number of Positive Pelvic Nodes • NAACCR # 3911: Peritoneal Cytology

Grade Table 13:

Code Grade Description 1 G1 FIGO Grade 1 G1: Well differentiated 2 G2 FIGO Grade 2 G2: Moderately differentiated 3 G3 FIGO Grade 3 G3: Poorly differentiated or undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 53: Corpus Uteri - Carcinoma and Carcinosarcoma

Histology Behavior AJCC ID Description 8000, 8010, 8013, 8020, 8041, 8070, 8140, 8240, 8255, 3 53 Corpus Uteri: 8263, 8310, 8323, 8380, 8382, 8441, 8460-8461, 8480, Carcinoma and 8560, 8570, 8950, 8980 Carcinosarcoma 8000, 8010, 8013, 8020, 8041, 8070, 8140, 8240, 8255, 2 XX Other Corpus Uteri: 8263, 8310, 8323, 8380, 8382, 8441, 8460-8461, 8480, Carcinoma and 8560, 8570, 8950, 8980 Carcinosarcoma 8001-8005, 8011-8012, 8014-8015, 8021-8040, 8042- Carcinoma and 8264-8300, 8311-8322, 8324-8375, 8381, 8383-8440, Carcinosarcoma 8442-8454, 8462-8474, 8481-8552, 8561-8562, 8571- 8700, 8720-8790, 9700-9701

88 | Page Version 1.7 Schema ID 00541: Corpus Sarcoma

Primary Site(s)/Histology(ies) Primary Site Histology C540-C549, C559 8710-8714, 8800-8932, 8934-8941, 8951-8975, 8981-9137, 9141-9582

AJCC Chapter 54: Corpus Uteri: Sarcoma EOD Schema: Corpus Sarcoma Summary Stage 2018 Chapter: Corpus Sarcoma

Applicable SSDIs

Grade Table 13:

AJCC ID 54.1: Corpus Uteri: Leiomyosarcoma and Endometrial Stromal Sarcoma

Histology AJCC ID Description 8714, 8800, 8805, 8890-8891, 8896, 8900, 8910, 8930- 54.1 Corpus Uteri: Leiomyosarcoma and 8931, 8935 Endometrial Stromal Sarcoma 8710-8713, 8801-8804, 8806-8881, 8892-8895, 8897- XX Other Corpus Uteri: 8898, 8901-8905, 8912-8921, 8932, 8934, 8936-8941, Leiomyosarcoma and Endometrial 8951-8975, 8981-9137, 9141-9582 Stromal Sarcoma

89 | Page Version 1.7 Schema ID 00542: Corpus Adenosarcoma

Primary Site(s)/Histology(ies) Primary Site Histology C540-C549, C559 8933

AJCC Chapter 54: Corpus Uteri: Sarcoma EOD Schema: Corpus Adenosarcoma Summary Stage 2018 Chapter: Corpus Sarcoma

Applicable SSDIs

Grade Table 13:

AJCC ID 54.2: Corpus Uteri: Adenosarcoma

Histology AJCC ID Description 8933 54.2 Corpus Uteri: Adenosarcoma

90 | Page Version 1.7 Schema ID 00551: Ovary

Primary Site(s)/Histology(ies) Primary Site Histology C569 8000-8700, 8720-8790, 8806, 8810, 8815, 8822, 8825, 8890, 8930-8931, 8933, 8935- 8936, 8950, 8960, 8980, 9000, 9050, 9052, 9060, 9070-9071, 9073, 9080, 9085, 9090- 9091, 9100, 9110, 9700-9701

AJCC Chapter 55: Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma EOD Schema: Ovary Summary Stage 2018 Chapter: Ovary and Primary Peritoneal Carcinoma

Applicable SSDIs

• NAACCR # 3818: CA-125 Pretreatment Interpretation • NAACCR # 3836: FIGO Stage (Ovary, Fallopian tube and Primary Peritoneal Carcinoma) • NAACCR # 3921: Residual Tumor Volume Post Cytoreduction

Grade Table 15:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated, undifferentiated B GB: Borderline Tumor L Low grade H High grade 9 Grade cannot be assessed (GX); Unknown

AJCC ID 55: Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma

Histology Behavior AJCC ID Description 8000, 8010, 8020, 8041, 8044, 8070, 8120, 8140, 8240, 3 55 Ovary, Fallopian 8243, 8310, 8323, 8410, 8441, 8452, 8460-8461, 8470, Tube, and Primary 8480, 8590, 8594, 8620, 8622-8623, 8631, 8633-8634, Peritoneal 8640, 8670, 8806, 8810, 8815, 8822, 8825, 8890, 8930- Carcinoma 8931, 8933, 8936, 8950, 8960, 8980, 9050, 9052, 9060, 9070-9071, 9073, 9080, 9085, 9090-9091, 9100, 9110 8313, 8380, 8442, 8472, 8474, 9000 0, 1, 3 55 Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma 8000, 8010, 8020, 8041, 8044, 8070, 8120, 8140, 8240, 0, 1, 2 XX Other Ovary, 8243, 8310, 8323, 8410, 8441, 8452, 8460-8461, 8470, Fallopian Tube, and 8480, 8590, 8594, 8620, 8622-8623, 8631, 8633-8634, Primary Peritoneal 8640, 8670, 8806, 8810, 8815, 8822, 8825, 8890, 8930- Carcinoma 8931, 8933, 8936, 8950, 8960, 8980, 9050, 9052, 9060, 9070-9071, 9073, 9080, 9085, 9090-9091, 9100, 9110

91 | Page Version 1.7 Histology Behavior AJCC ID Description 8313, 8380, 8442, 8472, 8474, 9000 2 XX Other Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma 8001-8005, 8011-8015, 8021-8040, 8042-8043, 8045-8060, Fallopian Tube, and 8311-8312, 8314-8322, 8324-8375, 8381-8409, 8413-8440, Primary Peritoneal 8443-8451, 8453-8454, 8462-8463, 8471, 8473, 8481-8589, Carcinoma 8591-8593, 8600-8610, 8621, 8630, 8632, 8641-8660, 8671- 8700, 8720-8790, 8935, 9700-9701

92 | Page Version 1.7 Schema ID 00552: Primary Peritoneal Carcinoma

Primary Site(s)/Histology(ies) Primary Site Histology Sex C481, C482, 8000-8700, 8720-8790, 8806, 8822, 8930-8931, 8933, 8950, 8960, 8980, 9000, 2, 6 C488 9050, 9052, 9060, 9070-9071, 9073, 9080, 9085, 9090-9091, 9100, 9110, 9700- 9701

AJCC Chapter 55: Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma EOD Schema: Primary Peritoneal Carcinoma Summary Stage 2018 Chapter: Ovary and Primary Peritoneal Carcinoma

Applicable SSDIs

Grade Table 15:

AJCC ID 55: Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma

Histology Behavior AJCC ID Description 8000, 8010, 8020, 8041, 8044, 8070, 8120, 8140, 8240, 3 55 Ovary, Fallopian 8243, 8310, 8323, 8410, 8441, 8452, 8460-8461, 8470, Tube, and Primary 8480, 8590, 8594, 8620, 8622-8623, 8631, 8633-8634, Peritoneal 8640, 8670, 8806, 8822, 8930-8931, 8933, 8950, 8960, Carcinoma 8980, 9050, 9052, 9060, 9070-9071, 9073, 9080, 9085, 9090-9091, 9100, 9110 8313, 8380, 8442, 8472, 8474, 9000 0, 1, 3 55 Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma 8000, 8010, 8020, 8041, 8044, 8070, 8120, 8140, 8240, 0, 1, 2 XX Other Ovary, 8243, 8310, 8323, 8410, 8441, 8452, 8460-8461, 8470, Fallopian Tube, and 8480, 8590, 8594, 8620, 8622-8623, 8631, 8633-8634, Primary Peritoneal 8640, 8670, 8806, 8822, 8930-8931, 8933, 8950, 8960, Carcinoma 8980, 9050, 9052, 9060, 9070-9071, 9073, 9080, 9085, 9090-9091, 9100, 9110

93 | Page Version 1.7 Histology Behavior AJCC ID Description 8313, 8380, 8442, 8472, 8474, 9000 2 XX Other Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma 8001-8005, 8011-8015, 8021-8040, 8042-8043, 8045-8060, Fallopian Tube, and 8311-8312, 8314-8322, 8324-8375, 8381-8409, 8413-8440, Primary Peritoneal 8443-8451, 8453-8454, 8462-8463, 8471, 8473, 8481-8589, Carcinoma 8591-8593, 8600-8610, 8621, 8630, 8632, 8641-8660, 8671- 8700, 8720-8790, 9700-9701

94 | Page Version 1.7 Schema ID 00553: Fallopian Tube

Primary Site(s)/Histology(ies) Primary Site Histology C570 8000-8700, 8720-8790, 8806, 8810, 8815, 8822, 8825, 8890, 8930-8931, 8933, 8935- 8936, 8950, 8960, 8980, 9000, 9050, 9052, 9060, 9070-9071, 9073, 9080, 9085, 9090- 9091, 9100, 9110, 9700-9701

AJCC Chapter 55: Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma EOD Schema: Fallopian Tube Summary Stage 2018 Chapter: Fallopian Tube

Applicable SSDIs

Grade Table 15:

AJCC ID 55: Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma

95 | Page Version 1.7 Histology Behavior AJCC ID Description 8313, 8380, 8442, 8472, 8474, 9000 2 XX Other Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma 8001-8005, 8011-8015, 8021-8040, 8042-8043, 8045-8060, Fallopian Tube, and 8311-8312, 8314-8322, 8324-8375, 8381-8409, 8413-8440, Primary Peritoneal 8443-8451, 8453-8454, 8462-8463, 8471, 8473, 8481-8589, Carcinoma 8591-8593, 8600-8610, 8621, 8630, 8632, 8641-8660, 8671- 8700, 8720-8790, 8935, 9700-9701

96 | Page Version 1.7 Schema ID 00558: Adnexa Uterine Other

Primary Site(s)/Histology(ies) Primary Site Histology C571-C574 8000-8700, 8720-8790, 9700-9701

AJCC Chapter: None EOD Schema: Adnexa Uterine Other Summary Stage 2018 Chapter: Adnexa Uterine Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

97 | Page Version 1.7 Schema ID 00559: Genital Female Other

Primary Site(s)/Histology(ies) Primary Site Histology C577-C579 8000-8700, 8720-8790, 9700-9701

AJCC Chapter: None EOD Schema: Genital Female Other Summary Stage 2018 Chapter: Genital Female Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

98 | Page Version 1.7 Schema ID 00560: Placenta

Primary Site(s)/Histology(ies) Primary Site Histology C589 8000-8700, 8720-8790, 9100-9105, 9700-9701

AJCC Chapter 56: Gestational Trophoblastic Tumors EOD Schema: Placenta Summary Stage 2018 Chapter: Placenta

Applicable SSDIs

• NAACCR # 3836: FIGO Stage (Gestational Trophoblastic Tumors) • NAACCR # 3837: Gestational Trophoblastic Prognostic Scoring Index

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 56: Gestational Trophoblastic Tumors

Histology Behavior AJCC ID Description 9100, 9104-9105 3 56 Gestational Trophoblastic Neoplasms 9100, 9104-9105 2 XX Other Gestational Trophoblastic Neoplasms 8000-8700, 8720-8790, 9101-9103, Neoplasms

99 | Page Version 1.7 Schema ID 00570: Penis

Primary Site(s)/Histology(ies) Primary Site Histology C600-C602, C608-C609 8000-8040, 8042-8180, 8191-8246, 8248-8700

AJCC Chapter 57: Penis EOD Schema: Penis Summary Stage 2018 Chapter: Penis

Applicable SSDIs

• NAACCR # 3830: Extranodal Extension Clin (non-Head and Neck • NAACCR # 3833: Extranodal Extension Path (non-Head and Neck)

Grade Table 16:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated/high grade 9 Grade cannot be assessed (GX); Unknown

AJCC ID 57: Penis

Histology AJCC ID Description 8000, 8010, 8051-8052, 8054, 8070-8072, 8074-8075, 8081-8084, 8560 57 Penis 8001-8005, 8011-8040, 8042-8050, 8053, 8060, 8073, 8076-8080, 8085-8180, XX Other Penis 8191-8246, 8248-8552, 8561-8700

100 | Page Version 1.7 Schema ID 00580: Prostate

Primary Site(s)/Histology(ies) Primary Site Histology C619 8000-8700, 8720-8790, 9700-9701

AJCC Chapter 58: Prostate EOD Schema: Prostate Summary Stage 2018 Chapter: Prostate

Applicable SSDIs

• NAACCR # 3838: Gleason Patterns Clinical • NAACCR # 3839: Gleason Patterns Pathological • NAACCR # 3840: Gleason Score Clinical • NAACCR # 3841: Gleason Score Pathological • NAACCR # 3842: Gleason Tertiary Pattern • NAACCR # 3897: Number of Cores Examined • NAACCR # 3898: Number of Cores Positive • NAACCR # 3920: PSA (Prostatic Specific Antigen) Lab Value

Grade Table 17:

Code Grade Description 1 Grade Group 1: Gleason score less than or equal to 6 2 Grade Group 2: Gleason score 7 Gleason pattern 3+4 3 Grade Group 3: Gleason score 7 Gleason pattern 4+3 4 Grade Group 4: Gleason score 8 5 Grade Group 5: Gleason score 9 or 10 A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic E Stated as “Gleason score 7” with no patterns documented or Any Gleason patterns combination equal to 7 not specified in 2 or 3 9 Grade cannot be assessed; Unknown

AJCC ID 58: Prostate

Histology Behavior AJCC ID Description 8000, 8010, 8013, 8041, 8070, 8120, 8140, 8147-8148, 8201, 3 58 Prostate 8230, 8240, 8260, 8480, 8490, 8500, 8560, 8572, 8574 8000, 8010, 8013, 8041, 8070, 8120, 8140, 8147-8148, 8201, 2 XX Other 8230, 8240, 8260, 8480, 8490, 8500, 8560, 8572, 8574 Prostate 8001-8005, 8011-8012, 8014-8040, 8042-8060, 8071-8110, 8121- Prostate 8261-8474, 8481-8482, 8501-8552, 8561-8571, 8573, 8575-8700, 8720-8790, 9700-9701

101 | Page Version 1.7 Schema ID 00590: Testis

Primary Site(s)/Histology(ies) Primary Site Histology C620-C621, C629 8000-8700, 8720-8790, 9061, 9064-9065, 9070-9071, 9080-9081, 9084-9085, 9100-9101, 9104-9105, 9700-9701

AJCC Chapter 59: Testis EOD Schema: Testis Summary Stage 2018 Chapter: Testis

Applicable SSDIs

• NAACCR # 3805: AFP Post-Orchiectomy Lab Value • NAACCR # 3806: AFP Post-Orchiectomy Range • NAACCR # 3807: AFP Pre-Orchiectomy Lab Value • NAACCR # 3808: AFP Pre-Orchiectomy Range • NAACCR # 3846: hCG Post-Orchiectomy Lab Value • NAACCR # 3847: hCG Post-Orchiectomy Range • NAACCR # 3848: hCG Pre-Orchiectomy Range • NAACCR # 3849: hCG Pre-Orchiectomy Lab Value • NAACCR # 3867: LDH Post-Orchiectomy Range • NAACCR # 3868: LDH Pre-Orchiectomy Range • NAACCR # 3923: S Category Clinical • NAACCR # 3924: S Category Pathological

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 59: Testis

Histology AJCC ID Description 8000, 8591, 8640, 8650, 9061, 9064-9065, 9070-9071, 9080-9081, 9084-9085, 59 Testis 9100-9101, 9104-9105 8001-8590, 8592-8634, 8641-8642, 8660-8700, 8720-8790, 9700-9701 XX Other Testis

102 | Page Version 1.7 Schema ID 00598: Genital Male Other

Primary Site(s)/Histology(ies) Primary Site Histology C630-C631, C637-C639 8000-8700, 8720-8790, 9700-9701 C632 8000-8040, 8042-8180, 8191-8246, 8248-8700

AJCC Chapter: None EOD Schema: Genital Male Other Summary Stage 2018 Chapter: Genital Male Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

103 | Page Version 1.7 Schema ID 00600: Kidney Parenchyma

Primary Site(s)/Histology(ies) Primary Site Histology C649 8000-8700, 8720-8790, 9700-9701

AJCC Chapter 60: Kidney EOD Schema: Kidney Parenchyma Summary Stage 2018 Chapter: Kidney Parenchyma

Applicable SSDIs

• NAACCR # 3861: Ipsilateral Gland Involvement • NAACCR # 3864: Invasion Beyond Capsule • NAACCR # 3886: Major Vein Involvement • NAACCR # 3925: Sarcomatoid Features

Grade Table 18:

Code Grade Description 1 G1: Nucleoli absent or inconspicuous and basophilic at 400x magnification 2 G2: Nucleoli conspicuous and eosinophilic at 400x magnification, visible but not prominent at 100x magnification 3 G3: Nucleoli conspicuous and eosinophilic at 100x magnification 4 G4: Marked nuclear pleomorphism and/or multinucleate giant cells and/or rhabdoid and/or sarcomatoid differentiation A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed (GX); Unknown

AJCC ID 60: Kidney

Histology Behavior AJCC ID Description 8000, 8010, 8140, 8255, 8260, 8310-8312, 8316-8319, 8323, 3 60 Kidney 8480, 8510 8000, 8010, 8140, 8255, 8260, 8310-8312, 8316-8319, 8323, 2 XX Other 8480, 8510 Kidney 8001-8005, 8011-8131, 8141-8254, 8256-8257, 8261-8300, 8313- Kidney 9700-9701

104 | Page Version 1.7 Schema ID 00610: Kidney Renal Pelvis

Primary Site(s)/Histology(ies) Primary Site Histology C659, C669 8000-8700, 8720-8790, 9700-9701

AJCC Chapter 61: Renal Pelvis and Ureter EOD Schema: Kidney Renal Pelvis Summary Stage 2018 Chapter: Kidney Renal Pelvis

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 19:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated L LG: Low-grade H HG: High-grade 9 Grade cannot be assessed (GX); Unknown

AJCC ID 61.1: Renal Pelvis and Ureter: Urothelial Carcinomas AJCC ID 61.2: Renal Pelvis and Ureter: Squamous Cell Carcinoma and Adenocarcinoma

Histology AJCC ID Description 8000, 8010, 8020, 8031, 8041, 8082, 8120, 8122, 61.1 Renal Pelvis and Ureter: Urothelial 8130-8131 Carcinomas 8070, 8140 61.2 Renal Pelvis and Ureter: Squamous Cell Carcinoma and Adenocarcinoma 8001-8005, 8011-8015, 8021-8030, 8032-8040, 8042- XX Other Kidney Renal Pelvis 8060, 8071-8081, 8083-8110, 8121, 8123-8124, 8141- 8700, 8720-8790, 9700-9701

105 | Page Version 1.7 Schema ID 00620: Bladder

Primary Site(s)/Histology(ies) Primary Site Histology C670-C679 8000-8700, 8720-8790, 9700-9701

AJCC Chapter 62: Urinary Bladder EOD Schema: Bladder Summary Stage 2018 Chapter: Bladder

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 19:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated L LG: Low-grade H HG: High-grade 9 Grade cannot be assessed (GX); Unknown

AJCC ID 62.1: Bladder: Urothelial Carcinomas AJCC ID 62.2: Bladder: Squamous Cell Carcinoma and Adenocarcinoma

Histology AJCC ID Description 8000, 8010, 8020, 8031, 8041, 8082, 8120, 8122, 8130, 62.1 Urinary Bladder: Urothelial 8131 Carcinomas 8070, 8140 62.2 Urinary Bladder: Squamous Cell Carcinoma and Adenocarcinoma 8001-8005, 8011-8015, 8021-8030, 8032-8040, 8042- XX Other Urinary Bladder 8060, 8071-8081, 8083-8110, 8121, 8123-8124, 8141- 8700, 8720-8790, 9700-9701

106 | Page Version 1.7 Schema ID 00631: Urethra

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C680 8000-8700, 8720-8790, 9700-9701 1

AJCC Chapter 63: Urethra EOD Schema: Urethra Summary Stage 2018 Chapter: Urethra

Applicable SSDIs

• NAACCR # 3926: Schema Discriminator 1 (Urethra/Prostatic Urethra)

Grade Table 19:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated L LG: Low-grade H HG: High-grade 9 Grade cannot be assessed (GX); Unknown

AJCC ID 63.1: Male Penile and Female Urethra: Urothelial Carcinomas AJCC ID 63.2: Male Penile and Female Urethra: Squamous Cell Carcinoma and Adenocarcinoma

Histology AJCC ID Description 8000, 8010, 8020, 8031, 8041, 8082, 8120, 8122, 63.1 Male Penile and Female Urethra: 8130-8131, 8310 Urothelial Carcinomas 8070-8072, 8140 63.2 Male Penile and Female Urethra: Squamous Cell Carcinoma and Adenocarcinoma 8001-8005, 8011-8015, 8021-8030, 8032-8040, 8042- XX Other Male Penile and Female 8060, 8073-8081, 8083-8110, 8121, 8123-8124, 8141- Urethra 8300, 8311-8700, 8720-8790, 9700-9701

107 | Page Version 1.7 Schema ID 00633: Urethra-Prostatic

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C680 8000-8700, 8720-8790, 9700-9701 2

AJCC Chapter 63: Urethra EOD Schema: Urethra-Prostatic Summary Stage 2018 Chapter: Urethra

Applicable SSDIs

• NAACCR # 3926: Schema Discriminator 1 (Urethra/Prostatic Urethra)

Grade Table 19:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated L LG: Low-grade H HG: High-grade 9 Grade cannot be assessed (GX); Unknown

AJCC ID 63.3: Prostatic Urethra: Urothelial Carcinomas AJCC ID 63.4: Prostatic Urethra: Squamous Cell Carcinoma and Adenocarcinoma

Histology AJCC ID Description 8000, 8010, 8020, 8031, 8041, 8082, 8120, 8122, 8130- 63.3 Prostatic Urethra: Urothelial 8131, 8310 Carcinomas 8070-8072, 8140 63.4 Prostatic Urethra: Squamous Cell Carcinoma and Adenocarcinoma 8001-8005, 8011-8015, 8021-8030, 8032-8040, 8042- XX Other Prostatic Urethra 8060, 8073-8081, 8083-8110, 8121, 8123-8124, 8141- 8300, 8311-8700, 8720-8790, 9700-9701

108 | Page Version 1.7 Schema ID 00638: Urinary Other

Primary Site(s)/Histology(ies) Primary Site Histology C681, C688-C689 8000-8700, 8720-8790, 9700-9701

AJCC Chapter: None EOD Schema: Urinary Other Summary Stage 2018 Chapter: Urinary Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

109 | Page Version 1.7 Schema ID 00640: Skin Eyelid

Primary Site(s)/Histology(ies) Primary Site Histology C441 8000-8040, 8042-8180, 8191-8246, 8248-8700, 8940-8941, 8980

AJCC Chapter 64: Eyelid Carcinoma EOD Schema: Skin of Eyelid Summary Stage 2018 Chapter: Skin of Eyelid

Applicable SSDIs

• NAACCR # 3909: Perineural Invasion

Grade Table 02:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 4 G4: Undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 64: Eyelid Carcinoma

Histology AJCC ID Description 8070, 8090, 8140, 8200, 8390, 8400-8401, 8407, 8410, 8413, 8430, 8480- 64 Eyelid 8481, 8940-8941, 8980 Carcinoma 8000-8040, 8042-8060, 8071-8086, 8091-8131, 8141-8180, 8191, 8201- XX Other Eyelid 8246, 8248-8384, 8391-8392, 8402-8406, 8408-8409, 8420, 8440-8474, Carcinoma 8482-8700

110 | Page Version 1.7 Schema ID 00650: Conjunctiva

Primary Site(s)/Histology(ies) Primary Site Histology C690 8000-8700, 9700-9701

AJCC Chapter 65: Conjunctival Carcinoma EOD Schema: Conjunctiva Summary Stage 2018 Chapter: Conjunctiva

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 02:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated 3 G3: Poorly differentiated 4 G4: Undifferentiated 9 Grade cannot be assessed (GX); Unknown

AJCC ID 65: Conjunctival Carcinoma

Histology AJCC ID Description 8010, 8070-8076, 8090, 8410, 8430, 8560 65 Conjunctival Carcinoma 8000-8005, 8011-8060, 8077-8086, 8091-8409, 8413-8420, 8440- XX Other Conjunctival 8552, 8561-8700, 9700-9701 Carcinoma

111 | Page Version 1.7 Schema ID 00660: Melanoma Conjunctiva

Primary Site(s)/Histology(ies) Primary Site Histology C690 8720-8790

AJCC Chapter 66: Conjunctival Melanoma EOD Schema: Melanoma Conjunctiva Summary Stage 2018 Chapter: Melanoma Conjunctiva

Applicable SSDIs

• NAACCR # 3888: Measured Thickness

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 66: Conjunctival Melanoma

Histology AJCC ID Description 8720-8721, 8723, 8730, 8740-8741, 8743, 8745, 8770 66 Conjunctival Melanoma 8722, 8725-8728, 8742, 8744, 8746-8762, 8771-8790 XX Other Conjunctival Melanoma

112 | Page Version 1.7 Schema ID 00671: Melanoma Iris

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C694 8720-8790 2

AJCC Chapter 67: Uveal Melanoma EOD Schema: Melanoma Iris Summary Stage 2018 Chapter: Melanoma Uvea

Applicable SSDIs

• NAACCR # 3821: Chromosome 3 Status • NAACCR # 3822: Chromosome 8q Status • NAACCR # 3834: Extravascular Matrix Pattern • NAACCR # 3887: Measured Basal Diameter • NAACCR # 3888: Measured Thickness • NAACCR # 3891: Microvascular Density • NAACCR # 3892: Mitotic Count Uveal Melanoma • NAACCR # 3926: Schema Discriminator 1 (Melanoma Ciliary Body/Melanoma Iris)

Grade Table 20:

Code Grade Description 1 G1: Spindle cell melanoma (>90% spindle cells) 2 G2: Mixed cell melanoma (>10% epithelioid cells and <90% spindle cells) 3 G3: Epithelioid cell melanoma (>90% epithelioid cells) A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed (GX); Unknown

AJCC ID 67.1: Uvea: Iris Melanomas

Histology Behavior AJCC ID Description 8720, 8730, 8770-8774 3 67.1 Uvea: Iris Melanomas 8720, 8730, 8770-8774 2 XX Other Uvea: Iris Melanomas 8721-8728, 8740-8762, 8780-8790 XX Other Uvea: Iris Melanomas

113 | Page Version 1.7 Schema ID 00672: Melanoma Choroid and Ciliary Body

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C693 8720-8790 C694 8720-8790 1

AJCC Chapter 67: Uveal Melanoma EOD Schema: Melanoma Choroid and Ciliary Body Summary Stage 2018 Chapter: Melanoma Uvea

Applicable SSDIs

Grade Table 20:

AJCC ID 67.2: Uvea: Choroidal and Ciliary Body Melanomas

Histology Behavior AJCC ID Description 8720, 8730, 8770-8774 3 67.2 Uvea: Choroidal and Ciliary Body Melanomas 8720, 8730, 8770-8774 2 XX Other Uvea: Choroidal and Ciliary Body Melanomas 8721-8728, 8740-8762, 8780- Melanomas

114 | Page Version 1.7 Schema ID 00680: Retinoblastoma

Primary Site(s)/Histology(ies) Primary Site Histology C690-C696, C698-C699 9510-9514

AJCC Chapter 68: Retinoblastoma EOD Schema: Retinoblastoma Summary Stage 2018 Chapter: Retinoblastoma

Applicable SSDIs

• NAACCR # 3856: Heritable Trait

Grade Table 21:

Code Grade Description 1 G1: Tumor with areas of retinoma [retinocytoma] (fleurettes or neuronal differentiation) 2 G2: Tumor with many rosettes (Flexner–Wintersteiner or Homer Wright) 3 G3: Tumor with occasional rosettes (Flexner–Wintersteiner or Homer Wright) 4 G4: Tumor with poorly differentiated cells without rosettes and/or with extensive areas (more than half of tumor) of anaplasia A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed (GX); Unknown

AJCC ID 68: Retinoblastoma

Primary Site Histology AJCC ID Description C692 9510-9513 68 Retinoblastoma C690-C691, C693-C696, C698-C699 9510-9513 XX Other Retinoblastoma C690-C696, C698-C699 9514 XX Other Retinoblastoma

115 | Page Version 1.7 Schema ID 00690: Lacrimal Gland

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C695 8000-8700, 8941, 8980, 8982, 9700-9701 1

AJCC Chapter 69: Lacrimal Gland Carcinoma EOD Schema: Lacrimal Gland Summary Stage 2018 Chapter: Lacrimal Gland/Sac

Applicable SSDIs

• NAACCR # 3803: Adenoid Cystic Basaloid Pattern • NAACCR # 3909: Perineural Invasion • NAACCR # 3926: Schema Discriminator 1 (Lacrimal Gland/Lacrimal Sac)

Grade Table 22:

Code Grade Description 1 G1: Well differentiated 2 G2: Moderately differentiated: includes adenoid cystic carcinoma without basaloid (solid) pattern 3 G3: Poorly differentiated: includes adenoid cystic carcinoma with basaloid (solid) pattern A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed (GX); Unknown

AJCC ID 69: Lacrimal Gland Carcinoma

Histology Behavior AJCC ID Description 8010, 8070-8072, 8082, 8140, 8147, 8200, 8410, 8430, 8440, 3 69 Lacrimal Gland 8450, 8480, 8500, 8525, 8550, 8562, 8941, 8980, 8982 Carcinoma 8010, 8070-8072, 8082, 8140, 8147, 8200, 8410, 8430, 8440, 2 XX Other Lacrimal 8450, 8480, 8500, 8525, 8550, 8562, 8941, 8980, 8982 Gland 8000-8005, 8011-8060, 8073-8081, 8083-8131, 8141-8146, Gland 8481-8490, 8501-8524, 8530-8543, 8551-8561, 8570-8700, 9700-9701

116 | Page Version 1.7 Schema ID 00698: Lacrimal Sac

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C695 8000-8700, 8941, 8980, 8982, 9700-9701 2, 9

AJCC Chapter: None EOD Schema: Lacrimal Sac Summary Stage 2018 Chapter: Lacrimal Gland/Sac

Applicable SSDIs

• NAACCR # 3926: Schema Discriminator 1 (Lacrimal Gland/Lacrimal Sac)

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

117 | Page Version 1.7 Schema ID 00700: Orbital Sarcoma

Primary Site(s)/Histology(ies) Primary Site Histology Behavior C690-C694, C696, 8710-8714, 8800-8921, 8932-8934, 8940-8990, 9000-9016, 9030-9137, C698-C699 9141-9175, 9181-9230, 9240-9509, 9520-9582 C695 8710-8714, 8800-8921, 8932-8934, 8940, 8950-8975, 8981, 8983-8990, 9000-9016, 9030-9137, 9141-9175, 9181-9230, 9240-9509, 9520-9582 C723 8710-8714, 8800-8921, 8932-8934, 8940-8990, 9000-9016, 9030-9063, 3 9065, 9071-9073, 9081-9083, 9086-9091, 9101-9137, 9141-9175, 9181- 9230, 9240-9361, 9363-9373, 9421, 9473, 9500, 9522, 9530, 9540-9582

AJCC Chapter 70: Orbital Sarcoma EOD Schema: Orbital Sarcoma Summary Stage 2018 Chapter: Orbital Sarcoma

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 09:

AJCC ID 70: Orbital Sarcoma

Primary Site Histology AJCC ID Description C690-C696, 8800-8802, 8804-8806, 8810-8811, 8814-8815, 8825, 8830, 70 Orbital C698-C699, 8832, 8840, 8850, 8852-8854, 8858, 8890, 8900-8901, 8910, Sarcoma C723 8912, 8920-8921, 8940, 8963, 9040, 9044, 9071, 9120, 9133, 9150, 9220, 9240, 9364, 9421, 9473, 9500, 9522, 9530, 9540, 9580-9581 C690-C696, 8710-8714, 8803, 8812-8813, 8820-8824, 8826-8827, 8831, XX Other Orbital C698-C699, 8833-8836, 8841-8842, 8851, 8855-8857, 8860-8881, 8891- Sarcoma C723 8898, 8902-8905, 8932-8934, 8950-8960, 8964-8975, 8981, 8983-8990 C690-C694, 8941, 8980, 8982 XX Other Orbital C696, C698- Sarcoma C699, C723 C690-C696, 9000-9016, 9030, 9041-9043, 9045-9063, 9065, 9072-9073, XX Other Orbital C698-C699, 9081-9083, 9086-9091, 9101-9110, 9121-9132, 9135-9137, Sarcoma C723 9141-9142, 9160-9175, 9363, 9365-9373, 9541-9571, 9582

118 | Page Version 1.7 Primary Site Histology AJCC ID Description C690-C696, 9064, 9070, 9080, 9084-9085, 9100, 9362, 9380-9420, 9423- XX Other Orbital C698-C699 9472, 9474-9493, 9501-9509, 9520-9521, 9523, 9531-9539 Sarcoma

119 | Page Version 1.7 Schema ID 00710: Lymphoma Ocular Adnexa

Primary Site(s)/Histology(ies) Primary Site Histology C441, C690, C695-C696 9590-9699, 9702-9719, 9725-9726, 9734-9738, 9823, 9826-9827, 9930

AJCC Chapter 71: Ocular Adnexal Lymphoma EOD Schema: Lymphoma Ocular Adnexa Summary Stage 2018 Chapter: Lymphoma Ocular Adnexa

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 23:

Code Grade Description 1 G1: 0–5 centroblasts per HPF 2 G2: 6-15 centroblasts per HPF 3 G3: > 15 centroblasts 4 G3A: >15 centroblasts per HPF and centrocytes present 5 G3B: > 15 centroblasts per HPF and solid sheets of centroblasts L Low grade: Grade 1-2 9 Grade cannot be assessed (GX); Unknown Not a follicular histology (9690/3, 9691/3, 9695/3, 9698/3)

AJCC ID 71: Ocular Adnexal Lymphoma

Histology AJCC ID Description 9590-9591, 9596-9597, 9671, 9673, 9680, 9690-9691, 9695, 9698- 71 Ocular Adnexal 9699, 9702, 9705, 9709, 9718, 9734, 9823, 9930 Lymphoma 9650-9663, 9678-9679, 9687-9689, 9708, 9712, 9714, 9716-9717, XX Other Ocular Adnexal 9719, 9725-9726, 9735-9738, 9826-9827 Lymphoma

120 | Page Version 1.7 Schema ID 00718: Eye Other

Primary Site(s)/Histology(ies) Primary Site Histology C691-C694, C696, C698-C699 8000-8700, 9700-9701 C691-C692, C695-C696, C698-C699 8720-8790

AJCC Chapter: None EOD Schema: Eye Other Summary Stage 2018 Chapter: Eye Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

121 | Page Version 1.7 Schema ID 00721: Brain

Primary Site(s)/Histology(ies) Primary Histology Behavior Site C700, 8000-8700, 8720-8790, 8802, 8810, 8815, 8850, 8890, 8900, 9064, 9070- 9364, 9380-9540, 9680, 9699, 9700-9714, 9751-9759 C700, 8710-8714, 8800-8801, 8803-8806, 8811-8814, 8820-8842, 8851-8881, 0,1 C710-C719 8891-8898, 8901-9063, 9065, 9072-9073, 9081-9083, 9086-9091, 9110, 9121-9132, 9135-9137, 9141-9175, 9181-9210, 9221-9361, 9363, 9365- 9373, 9541-9582 C700, 9590-9679, 9687-9698, 9716-9742, 9761-9992 0,1 C710-C719

AJCC Chapter 72: Brain and Spinal Cord EOD Schema: Brain Summary Stage 2018 Chapter: Brain

Applicable SSDIs

• NAACCR # 3801: Chromosome 1p: Loss of Heterozygosity (LOH) • NAACCR # 3802: Chromosome 19q: Loss of Heterozygosity (LOH) • NAACCR # 3816: Brain Molecular Markers • NAACCR # 3889: Methylation of O6-Methylguanine-Methyltransferase

Grade Table 24:

Code Grade Description 1 WHO Grade I: Circumscribed tumors of low proliferative potential associated with the possibility of cure following resection 2 WHO Grade II: Infiltrative tumors with low proliferative potential with increased risk of recurrence 3 WHO Grade III: Tumors with histologic evidence of malignancy, including nuclear atypia and mitotic activity, associated with an aggressive clinical course 4 WHO Grade IV: Tumors that are cytologically malignant, mitotically active, and associated with rapid clinical progression and potential for dissemination L Stated as “low grade” NOS H Stated as “high grade” NOS A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

122 | Page Version 1.7 AJCC ID 72: Brain and Spinal Cord

Histology Behavior AJCC ID Description 8720, 8728, 8802, 8810, 8815, 8850, 8890, 8900, 9064, 9070- 3 VALUE:72 Brain and 9071, 9080, 9084-9085, 9100, 9120, 9133, 9140, 9180, 9220, Spinal Cord 9362, 9364, 9382, 9385, 9390-9393, 9395-9396, 9400-9401, 9411, 9424-9425, 9430, 9440-9442, 9445, 9450-9451, 9470- 9471, 9473-9478, 9490, 9500-9501, 9505, 9508, 9530, 9538, 9540, 9680, 9699, 9702, 9712, 9714, 9751, 9755 8710-8720, 8728, 8800-9100, 9110-9373, 9382, 9385-9393, 0, 1 XX Other Brain 9395-9401, 9411, 9424-9430, 9440-9442, 9445-9451, 9470- 9471, 9473-9478, 9490, 9500-9501, 9505, 9508, 9530, 9538, 9540-9699, 9702, 9712-9755, 9761-9992 8000-8700, 8721-8727, 8730-8790, 9101-9105, 9380-9381, 9472, 9480, 9491-9493, 9502-9504, 9506-9507, 9509-9523, 9531-9537, 9539, 9700-9701, 9705-9709, 9756-9759

123 | Page Version 1.7 Schema ID 00722: CNS Other

Primary Site(s)/Histology(ies) Primary Site Histology Behavior C701, C709, 8000-8700, 8720-8790, 8802, 8810, 8815, 8850, 8890, 8900, 9064, 9070- C728-C729 9364, 9380-9540, 9680, 9699, 9700-9714, 9751-9759 C701, C709, 8710-8714, 8800-8801, 8803-8806, 8811-8814, 8820-8842, 8851-8881, 0,1 C720-C721, 8891-8898, 8901-9063, 9065, 9072-9073, 9081-9083, 9086-9091, 9110, C728-C729 9121-9132, 9135-9137, 9141-9175, 9181-9210, 9221-9361, 9363, 9365- 9373, 9541-9582 C722, C724- 8000-8700, 8720-8790, 8900, 9064, 9070-9071, 9080, 9084-9085, 9100, C722, C724- 8710-8714, 8800-8898, 8901-9063, 9065, 9072-9073, 9081-9083, 9086- 9582 C723 8000-8700, 8720-8790, 9064, 9070, 9080, 9084-9085, 9100, 9140, 9180, 9680, 9699, 9700-9714, 9751-9759 C723 8710-8714, 8800-9063, 9065, 9071-9073, 9081-9083, 9086-9091, 9101- 0, 1 9137, 9141-9175, 9181-9361, 9363-9373, 9421, 9473, 9500, 9522, 9530, 9540-9582 C701, C709, 9590-9679, 9687-9698, 9716-9742, 9761-9992 0, 1 C720-C729

AJCC Chapter 72: Brain and Spinal Cord EOD Schema: CNS Other Summary Stage 2018 Chapter: CNS Other

Applicable SSDIs

Grade Table 24:

124 | Page Version 1.7 Code Grade Description H Stated as “high grade” NOS A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 72: Brain and Spinal Cord

Primary Site Histology Behavior AJCC ID Description C701, C709, 8720, 8728, 9064, 9070, 9080, 9084-9085, 3 VALUE:72 Brain and C720-C729 9100, 9140, 9362, 9382, 9385, 9390-9393, Spinal Cord 9395-9401, 9411, 9424-9430, 9440-9442, 9445-9451, 9470-9471, 9474-9478, 9490, 9501, 9505, 9508, 9538, 9680, 9699, 9702, 9712, 9714, 9751, 9755 C701, C709, 8802, 8810, 8815, 8850, 8890, 9133, 9364, 3 VALUE:72 Brain and C720-C721, 9540 Spinal Cord C728-C729 C701, C709, 8900, 9071, 9120, 9220, 9473, 9500, 9530 3 VALUE:72 Brain and C720-C722, Spinal Cord C724-C729 C701, C709, 9180 3 VALUE:72 Brain and C720-C721, Spinal Cord C723, C728- C729 C701, C709, 8720, 8728, 9064, 9070, 9080, 9084-9085, 0, 1 XX Other CNS C720-C729 9100, 9140, 9362, 9382, 9385, 9390-9393, Other 9395-9401, 9411, 9424-9430, 9440-9442, 9445-9451, 9470-9471, 9474-9478, 9490, 9501, 9505, 9508, 9538, 9680, 9699, 9702, 9712, 9714, 9751, 9755, 8710-8714, 8800- 8801, 8803-8806, 8811-8814, 8820-8842, 8851-8881, 8891-8898, 8901-9063, 9065, 9072-9073, 9081-9083, 9086-9091, 9110, 9121-9132, 9135-9137, 9141-9175, 9181- 9210, 9221-9361, 9363, 9365-9373, 9541- 9582, 9590-9679, 9687-9698, 9716-9742, 9761-9992 C701, C709, 8802, 8810, 8815, 8850, 8890, 9133, 9364, 0, 1 XX Other CNS C720-C721, 9540 Other C728-C729 C701, C709, 8900, 9071, 9120, 9220, 9473, 9500, 9530 0, 1 XX Other CNS C720-C722, Other C724-C729 C701, C709, 9180 0, 1 XX Other CNS C720-C721, Other C723, C728-

125 | Page Version 1.7 Primary Site Histology Behavior AJCC ID Description C729, C722, C724-C725 C701, C709, 8000-8700, 8721-8727, 8730-8790, 9380- Other 9423, 9431-9432, 9444, 9460, 9472, 9480, 9491-9493, 9502-9504, 9506-9507, 9509- 9521, 9523, 9531-9537, 9539, 9700-9701, 9705-9709, 9756-9759 C701, C709, 9101-9105 Other C728-C729 C701, C709, 9421, 9522 Other C724-C729 C722-C725 8802, 8810, 8815, 8850, 8890, 9101-9105, 0, 1 XX Other CNS 9133, 9364, 9540 Other C723 8900, 9071, 9120, 9220, 9421, 9473, 9500, 0, 1 XX Other CNS 9522, 9530 Other

126 | Page Version 1.7 Schema ID 00723: Intracranial Gland

Primary Site(s)/Histology(ies) Primary Site Histology Behavior C751, C752, 8000-8700, 8720-8790, 8900, 9064, 9070-9071, 9080, 9084-9085, 9100, C751, C752, 8710-8714, 8800-8898, 8901-9063, 9065, 9072-9073, 9081-9083, 9086- 0, 1 C753 9091, 9101-9110, 9121-9137, 9141-9210, 9221-9361, 9363-9373, 9540- 9582, 9590-9679, 9687-9698, 9716-9742, 9761-9992

AJCC Chapter 72: Brain and Spinal Cord EOD Schema: Intracranial Gland Summary Stage 2018 Chapter: Intracranial Gland

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 24:

AJCC ID 72: Brain and Spinal Cord

Histology Behavior AJCC ID Description 8720, 8728, 8900, 9064, 9070-9071, 9080, 9084-9085, 9100, 9120, 3 72 Brain and 9140, 9220, 9362, 9382, 9385, 9390-9393, 9395-9396, 9400-9401, Spinal Cord 9411, 9424-9425, 9430, 9440-9442, 9445, 9450-9451, 9470-9471, 9473-9478, 9490, 9500-9501, 9505, 9508, 9530, 9538, 9680, 9699, 9702, 9712, 9714, 9751, 9755

127 | Page Version 1.7 Histology Behavior AJCC ID Description 8720, 8728, 8900, 9064, 9070-9071, 9080, 9084-9085, 9100, 9120, 0, 1 XX Other 9140, 9220, 9362, 9382, 9385, 9390-9393, 9395-9396, 9400-9401, Intracranial 9411, 9424-9425, 9430, 9440-9442, 9445, 9450-9451, 9470-9471, Gland 9473-9478, 9490, 9500-9501, 9505, 9508, 9530, 9538, 9680, 9699, 9702, 9712, 9714, 9751, 9755, 8710-8714, 8800-8898, 8901-9063, 9065, 9072-9073, 9081-9083, 9086-9091, 9101-9110, 9121-9137, 9141-9210, 9221-9361, 9363-9373, 9540-9582, 9590-9679, 9687- 9698, 9716-9742, 9761-9992 8000-8700, 8721-8727, 8730-8790, 9380-9381, 9383-9384, 9394, Intracranial 9502-9504, 9506-9507, 9509-9523, 9531-9537, 9539, 9700-9701, Gland 9705-9709, 9756-9759

128 | Page Version 1.7 Schema ID 00730: Thyroid

Primary Site(s)/Histology(ies) Primary Site Histology C739 8000-8344, 8350-8420, 8440-8509, 8514-8700, 8720-8790, 9700-9701

AJCC Chapter 73: Thyroid - Differentiated and Anaplastic EOD Schema: Thyroid Summary Stage 2018 Chapter: Thyroid (including Medullary)

Applicable SSDIs

• NAACCR # 3926: Schema Discriminator 1 (Thyroid Gland/Thyroglossal Duct)

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 73.1: Thyroid: Differentiated AJCC ID 73.2: Thyroid: Anaplastic

Histology Behavior Schema AJCC ID Description Discriminator 1 8000, 8010, 8050, 8230, 8260, 8290, 8330- 3 1 73.1 Thyroid: 8331, 8335, 8337, 8339, 8340-8344 Differentiated 8020-8021 3 1 73.2 Thyroid: Anaplastic 8000, 8010, 8020-8021, 8050, 8230, 8260, 2 1 XX Other Thyroid 8290, 8330-8331, 8335, 8337, 8339, 8340- 8344 8000, 8010, 8020-8021, 8050, 8230, 8260, 8344 8001-8005, 8011-8015, 8022-8046, 8051- XX Other Thyroid 8221, 8231-8257, 8261-8281, 8300-8325, value> 8332-8334, 8336, 8350-8420, 8440-8509, 8514-8700, 8720-8790, 9700-9701

129 | Page Version 1.7 Schema ID 00740: Thyroid Medullary

Primary Site(s)/Histology(ies) Primary Site Histology C739 8345-8347, 8430, 8510, 8512-8513

AJCC Chapter 74: Thyroid - Medullary EOD Schema: Thyroid Medullary Summary Stage 2018 Chapter: Thyroid (including Medullary)

Applicable SSDIs

• NAACCR # 3926: Schema Discriminator 1 (Thyroid Gland/Thyroglossal Duct)

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 74: Thyroid – Medullary

Histology Behavior Schema AJCC ID Description Discriminator 1 8345-8347 3 1 74 Thyroid: Medullary 8345-8347 2 1 XX Other Thyroid: Medullary 8345-8347 2 XX Other Thyroid: Medullary 8430, 8510, 8512-8513 XX Other Thyroid: Medullary

130 | Page Version 1.7 Schema ID 00750: Parathyroid

Primary Site(s)/Histology(ies) Primary Site Histology C750 8000-8700, 8720-8790, 9700-9701

AJCC Chapter 75: Parathyroid EOD Schema: Parathyroid Summary Stage 2018 Chapter: Parathyroid

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 25:

Code Grade Description L LG: Low grade: round monomorphic nuclei with only mild to moderate nuclear size variation, indistinct nucleoli, and chromatin characteristics resembling those of normal parathyroid or of adenoma H HG: High grade: more pleomorphism, with a nuclear size variation greater than 4:1; prominent nuclear membrane irregularities; chromatin alterations, including hyperchromasia or margination of chromatin; and prominent nucleoli. High-grade tumors show several discrete confluent areas with nuclear changes A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 75: Parathyroid

Histology AJCC ID Description 8000-8001, 8005, 8010, 8140, 8290, 8310, 8322 75 Parathyroid 8002-8004, 8011-8131, 8141-8281, 8300, 8311-8321, 8323-8700, 8720- XX Other 8790, 9700-9701 Parathyroid

131 | Page Version 1.7 Schema ID 00760: Adrenal Gland

Primary Site(s)/Histology(ies) Primary Site Histology C740-C741, C749 8000-8671, 8681-8683, 8691, 8720-8790, 9700-9701

AJCC Chapter 76: Adrenal Cortical Carcinoma EOD Schema: Adrenal Gland Summary Stage 2018 Chapter: Adrenal Gland (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 26:

Code Grade Description L LG: Low grade (≤20 mitoses per 50 HPF) H HG: High grade (>20 mitosis per 50 HPF) M TP53 or CTNNB Mutation A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed (GX); Unknown

AJCC ID 76: Adrenal Cortical Carcinoma

Primary Site Histology Behavior AJCC ID Description C740 8010, 8290, 8370 3 76 Adrenal Cortical Carcinoma C740 8010, 8290, 8370 2 XX Other Adrenal Gland C741, C749 8010, 8290, 8370 Gland C740-C741, 8000-8005, 8011-8281, 8300-8361, 8371- Gland 9701

132 | Page Version 1.7 Schema ID 00770: NET Adrenal Gland

Primary Site(s)/Histology(ies) Primary Site Histology C740, C741, C749, C755 8680, 8690, 8692-8693, 8700

AJCC Chapter 77: Adrenal - Neuroendocrine Tumors EOD Schema: NET Adrenal Gland Summary Stage 2018 Chapter: Adrenal Gland (including NET)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 98:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID 76: Adrenal Cortical Carcinoma

Primary Site Histology Behavior AJCC ID Description C741, C755 8680, 8690, 8692-8693, 3 77 Adrenal Neuroendocrine Tumors 8700 C741, C755 8680, 8690, 8692-8693, 2 XX Other Adrenal Neuroendocrine 8700 Tumors C740, C749 8680, 8690, 8692-8693, Tumors

133 | Page Version 1.7 Schema ID 00778: Endocrine Other

Primary Site(s)/Histology(ies) Primary Site Histology C754, C758-C759 8000-8700, 8720-8790, 9700-9701 C755 8000-8671, 8681-8683, 8691, 8720-8790, 9700-9701

AJCC Chapter: None EOD Schema: Endocrine Other Summary Stage 2018 Chapter: Endocrine Other

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

134 | Page Version 1.7 Schema ID 00790: Lymphoma (excluding CLL/SLL)

Primary Site(s)/Histology(ies) Primary Site Histology Behavior Schema Discriminator 1 C000-C424, C470-C509, C511- 9590, 9596-9663, 9673-9699, 9702- C608, C619-C631, C637-C689, 9719, 9725-9726, 9735, 9737-9738 C691-C694, C698-C699, C739- C749, C760-C809 C440, C442-C449, C510, C609, 9590, 9596, 9650-9663, 9673-9679, C632 9687-9699, 9702-9705, 9714-9717, 9725, 9735, 9737-9738 C700-C729, C751-C753 9590, 9596-9663, 9673-9679, 9687- 3 9698, 9716-9719, 9725-9726, 9735, 9737-9738 C750, C754-C759 9590, 9596-9663, 9673-9679, 9687- 9698, 9716-9719, 9725-9726, 9735, 9737-9738 C000-C440, C442-C689, C691- 9591 3, 9 C694, C698-C699, C739-C749, C750, C754-C759, C760-C809 C700-C729, C751-C753 9591 3 3, 9 C750, C754-C759 9680, 9699, 9702-9714 C000-C440, C442-C689, C691- 9826-9827 C694, C698-C699, C739-C749, C750, C754-C759, C760-C809 C700-C729, C751-C753 9826-9827 3

AJCC Chapter 79: Hodgkin and Non-Hodgkin Lymphomas AJCC Chapter 80: Pediatric Hodgkin and Non-Hodgkin Lymphomas EOD Schema: Lymphoma Summary Stage 2018 Chapter: Lymphoma (including CLL/SLL)

Applicable SSDIs

• NAACCR # 3812: B symptoms • NAACCR # 3859: HIV Status • NAACCR # 3896: NCCN International Prognostic Index (IPI) • NAACCR # 3926: Schema Discriminator 1 (Histology Discriminator for 9591/3)

Grade Table 88:

Code Grade Description 8 Not applicable

135 | Page Version 1.7 AJCC IDs 79.0-C79.4, C79.6-C79.7: Hodgkin and Non-Hodgkin Lymphomas (excluding CLL/SLL)

Histology Primary Site AJCC ID Description 9590-9591, 9596, 9687, 9826 C000-C424, C470-C509, C511- VALUE:79.0 Non-Hodgkin C608, C619-C631, C637-C689, Lymphomas: C691-C694, C739-C749, C760- Unspecified or Other C809 Type 9678-9680, 9688, 9712, 9735, C000-C424, C470-C509, C511- VALUE:79.1 Non-Hodgkin 9737-9738 C608, C619-C631, C637-C689, Lymphomas: Diffuse C691-C694, C739-C749, C760- Large B Cell C809 Lymphoma 9673 C000-C424, C470-C509, C511- VALUE:79.2 Non-Hodgkin C608, C619-C631, C637-C689, Lymphomas: Mantle C691-C694, C739-C749, C760- Cell Lymphoma C809 9690-9691, 9695, 9698 C000-C424, C470-C509, C511- VALUE:79.3 Non-Hodgkin C608, C619-C631, C637-C689, Lymphomas: C691-C694, C739-C749, C760- Follicular Lymphoma C809 9689, 9699 C000-C424, C470-C509, C511- VALUE:79.4 Non-Hodgkin C608, C619-C631, C637-C689, Lymphomas: C691-C694, C739-C749, C760- Marginal Zone C809 Lymphoma 9702, 9705, 9708-9709, 9714, C000-C424, C470-C509, C511- VALUE:79.6 Non-Hodgkin 9716-9719, 9725-9726, 9827 C608, C619-C631, C637-C689, Lymphomas: C691-C694, C739-C749, C760- Peripheral T-cell C809 Lymphoma 9650-9653,9655, 9659, 9663 C000-C424, C470-C509, C511- VALUE:79.7 Hodgkin Lymphoma C608, C619-C631, C637-C689, C691-C694, C739-C749, C760- C809 9597 C000-C424, C470-C509, C511- VALUE:XX Other Lymphomas C608, C619-C631, C637-C689, C691-C694, C698-C699, C739- C749, C760-C809 9590-9591, 9596, 9650-9663, C440, C442-C449, C510, C609, VALUE:XX Other Lymphomas 9673-9679, 9687-9699, 9702- C632, C698-C699 9705, 9714-9717, 9725, 9735, 9737-9738, 9826-9827 9680, 9708-9712, 9718-9719, C698-C699 VALUE:XX Other Lymphomas 9726 9590-9591, 9596-9663, 9673- C700-C729,C750-C759 VALUE:XX Other Lymphomas 9679, 9687-9698, 9716-9719, 9725-9726, 9735, 9737-9738, 9826-9827 9680, 9699,9702-9714 C750,C754-C759 VALUE:XX Other Lymphomas

136 | Page Version 1.7 Schema ID 00795: Lymphoma-CLL/SLL

Primary Site(s)/Histology(ies) Primary Site Histology Behavior C000-C440, C442-C689, C691-C694, C698-C699, C739-C750, C754-C809 9823 C700-C729, C751-C753 9823 3

AJCC Chapter 79: Hodgkin and Non-Hodgkin Lymphomas AJCC Chapter 80: Pediatric Hodgkin and Non-Hodgkin Lymphomas EOD Schema: Lymphoma-CLL/SLL Summary Stage 2018 Chapter: Lymphoma (including CLL/SLL)

Applicable SSDIs

• NAACCR # 3804: Adenopathy • NAACCR # 3811: Anemia • NAACCR # 3812: B symptoms • NAACCR # 3859: HIV Status • NAACCR # 3885: Lymphocytosis • NAACCR # 3896: NCCN International Prognostic Index (IPI) • NAACCR # 3907: Organomegaly • NAACCR # 3933: Thrombocytopenia

Grade Table 88:

Code Grade Description 8 Not applicable

AJCC IDs 79.5: Non-Hodgkin Lymphomas: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Primary Site AJCC ID Description C000-C424,C470-C509,C511-C608,C619- VALUE:79.5 Non-Hodgkin Lymphomas: Chronic C631,C637-C689,C691-C694,C739-C749,C760- Lymphocytic Leukemia/Small C809 Lymphocytic Lymphoma C440,C442-C449,C510,C609,C632,C698- VALUE:XX Other Non-Hodgkin Lymphomas: C699,C700-C729,C750-C759 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

137 | Page Version 1.7 Schema ID 00811: Mycosis Fungoides

Primary Site(s)/Histology(ies) Primary Site Histology C000-C002, C006, C440-C449, C510-C512, C518-C519, C600-C602, C608-C609, C632 9700-9701

AJCC Chapter 81: Primary Cutaneous Lymphomas EOD Schema: Mycosis Fungoides Summary Stage 2018 Chapter: Mycosis Fungoides

Applicable SSDIs

• NAACCR # 3910: Peripheral Blood Involvement

Grade Table 88:

Code Grade Description 8 Not applicable

AJCC ID 81.1: Primary Cutaneous Lymphomas: Mycosis Fungoides and Sézary Syndrome

Primary Site Histology AJCC ID Description C440, C442-C449, C510, C609, 9700, 81.1 Primary Cutaneous Lymphomas: Mycosis C632 9701 Fungoides and Sézary Syndrome C000-C002, C006, C441, C511- 9700, XX Other Primary Cutaneous Lymphomas: C512, C518-C519, C600-C602, 9701 Mycosis Fungoides and Sézary Syndrome C608

138 | Page Version 1.7 Schema ID 00812: Primary Cutaneous Lymphomas (excluding MF and SS)

Primary Site(s)/Histology(ies) Primary Site Histology C440, C442-C449, C510, C609, C632 9597, 9680, 9708-9709, 9712, 9718-9719, 9726

AJCC Chapter 81: Primary Cutaneous Lymphomas EOD Schema: Primary Cutaneous Lymphomas (excluding MF and SS) Summary Stage 2018 Chapter: Primary Cutaneous Lymphomas (excluding MF and SS)

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 88:

Code Grade Description 8 Not applicable

AJCC ID 81.2: Primary Cutaneous Lymphomas: Primary Cutaneous B-Cell/T-cell Lymphoma (non- MF/SS) Lymphoma

Histology AJCC ID Description 9597, 9680, 9708-9709, 9712, 81.2 Primary Cutaneous Lymphomas: Primary Cutaneous B- 9718-9719, 9726 Cell/T-cell Lymphoma (non-MF/SS) Lymphoma

139 | Page Version 1.7 Schema ID 00821: Plasma Cell Myeloma

Primary Site(s)/Histology(ies) Primary Site Histology Behavior C000-C699, C739-C750, C754-C809 9732 C700-C729, C751-C753 9732 3

AJCC Chapter 82: Plasma Cell Myeloma and Plasma Cell Disorders EOD Schema: Plasma Cell Myeloma Summary Stage 2018 Chapter: Myeloma and Plasma Cell Disorders

Applicable SSDIs

• NAACCR # 3857: High Risk Cytogenetics • NAACCR # 3869: LDH Pretreatment Level • NAACCR # 3926: Schema Discriminator 1 (Multiple Myeloma Terminology) • NAACCR # 3930: Serum Albumin Pretreatment Level • NAACCR # 3931: Serum Beta-2 Microglobulin Pretreatment Level

Grade Table 88:

Code Grade Description 8 Not applicable

AJCC ID 82.1: Plasma Cell Myeloma

Primary Site Discriminator 1 AJCC ID Description C000-C301, C320-C399, C420, C422-C424, C441, C470- XX Other Plasma Cell C499, C500-C509, C529-C589, C619-C631, C637-C809 Myeloma C310-C319, C400-C419, C421, C440, C442-C449, C510- 0 82.1 Plasma Cell C519, C600-C609, C632 Myeloma C310-C319, C400-C419, C421, C440, C442-C449, C510- 1, 9 XX Other Plasma Cell C519, C600-C609, C632 Myeloma

140 | Page Version 1.7 Schema ID 00822: Plasma Cell Disorders

Primary Site(s)/Histology(ies) Primary Site Histology Behavior C000-C440, C442-C689, C691-C694, C698-C699, C739-C750, 9671, 9734 C754-C809 C000-C699, C739-C750, C754-C809 9731, 9761 C700-C729, C751-C753 9671, 9731, 9734, 9761 3

AJCC Chapter 82: Plasma Cell Myeloma and Plasma Cell Disorders EOD Schema: Plasma Cell Disorders Summary Stage 2018 Chapter: Myeloma and Plasma Cell Disorders

Applicable SSDIs

• No SSDIs defined for this Schema ID

Grade Table 88:

Code Grade Description 8 Not applicable

AJCC ID 82.2: Plasma Cell Disorders

Histology Primary Site AJCC ID Description 9671,9731,9734,9761 C310-C319, C400-C419, C421, C440, VALUE:82.2 Plasma Cell Disorders C442-C449, C510-C519, C600-C609, C632 9671,9731,9734,9761 C000-C301, C320-C399, C420, C422- VALUE:XX Other Plasma Cell C424, C470-C499, C500-C509, C529- Disorders C589, C619-C631, C637-C689, C691- C694, C698-C809 9731,9761 C441, C690, C695-C696 VALUE:XX Other Plasma Cell Disorders

141 | Page Version 1.7 Schema ID 00830: HemeRetic

Primary Site(s)/Histology(ies) Primary Site Histology Behavior Schema Discriminator 1 C000-C440, C442-C689, C691- 9591 1, 2 C694, C698-C699, C739-C749, C750, C754-C759, C760-C809 C700-C729, C751-C753 9591 3 1, 2

C000-C699, C739-C750, C754- 9724, 9727, 9740-9742, 9762- C809 9809, 9811-9820, 9831-9920, 9931-9992 C700-C729, C751-C753 9724, 9727, 9740-9742, 9762- 3 9809, 9811-9820, 9831-9920, 9931-9992 C000-C699, C739-C750, C754- 9751, 9755-9759 C809 C000-C440, C442-C689, C691- 9930 C694, C698-C699, C739-C750, C754-C809

C700-C729, C751-C753 9930 3

AJCC Chapter 83: Leukemia EOD Schema: HemeRetic Summary Stage 2018 Chapter: HemeRetic

Applicable SSDIs

• NAACCR # 3862: JAK2 • NAACCR # 3926: Schema Discriminator 1 (Histology Discriminator for 9591/3)

Grade Table 88:

Code Grade Description 8 Not applicable

AJCC IDs 83.0-83.4: Leukemia

Histology Primary Site Age at AJCC ID Description Diagnosis 9591, 9724, 9727, 9801, C421 * VALUE:83.0 Leukemia: Unspecified 9806-9809, 9831, 9833- or Other Type 9834, 9940, 9948 9840, 9861, 9865-9867, C421 * VALUE:83.1 Leukemia: Acute 9869-9874, 9891, 9895- Myeloid Leukemia 9898, 9910-9911, 9920, 9930-9931

142 | Page Version 1.7 Histology Primary Site Age at AJCC ID Description Diagnosis 9811-9818,9837 C421 0-9, 00- VALUE:83.2 Leukemia: Acute 19, 000- Lymphoblastic Leukemia 019, 999 in children 9811-9818,9837 C421 20-99, VALUE:83.3 Leukemia: Acute 020-120 Lymphoblastic Leukemia in adults 9875,9876,9945 C421 * VALUE:83.4 Leukemia: Chronic Myeloid Leukemia 9591 C000-C420, * VALUE:XX Other HemeRetic C422-C440, C442-C689, C691-C694, C698-C699, C739-C749, C760-C809 9591 C700-C729, * VALUE:XX Other HemeRetic C750-C759 9724, 9727, 9801, 9806- C000-C420, * VALUE:XX Other HemeRetic 9809, 9811-9818, 9831, C422-C809 9833-9834, 9837, 9840, 9861, 9865-9867, 9869- 9876, 9891, 9895-9898, 9910-9911, 9920, 9931, 9940, 9945, 9948 9930 C000-C420, * VALUE:XX Other HemeRetic C422-C440, C442-C689, C691-C694, C698-C809 9740-9742, 9762-9800, C000-C809 * VALUE:XX Other HemeRetic 9820, 9832, 9860, 9863, 9946, 9950-9992 9751, 9755-9759 C000-C699, * VALUE:XX Other HemeRetic C739-C750, C754-C809

143 | Page Version 1.7 Schema ID 99999: Ill-Defined Other

Primary Site(s)/Histology(ies) Primary Site Histology Schema Discriminator 1 C420-C424, C761-C765, C767-C768, 8000-8700, 8720-8790, 9700-9701 C770-C775, C778-C779 C760 8000-8700, 8720-8790, 9700-9701 0, 1 C809 8000-8180, 8191-8246, 8248-8700, 8720-8790, 9700-9701

AJCC Chapter: None EOD Schema: Ill-Defined Other Summary Stage 2018 Chapter: Ill-Defined Other

Applicable SSDIs

• NAACCR # 3926: Schema Discriminator 1: Occult Head and Neck Lymph Nodes o Primary site C760 only Grade Table 99:

Code Grade Description A Well differentiated B Moderately differentiated C Poorly differentiated D Undifferentiated, anaplastic 9 Grade cannot be assessed; Unknown

AJCC ID: XX

144 | Page Version 1.7