North African Jewish and Non-Jewish Populations Form Distinctive, Orthogonal Clusters
North African Jewish and non-Jewish populations form distinctive, orthogonal clusters Christopher L. Campbella,1, Pier F. Palamarab,1, Maya Dubrovskyc,d,1, Laura R. Botiguée, Marc Fellousf, Gil Atzmong,h, Carole Oddouxa, Alexander Pearlmana, Li Haoi, Brenna M. Hennj, Edward Burnsg, Carlos D. Bustamantej, David Comase, Eitan Friedmanc,d, Itsik Pe’erb, and Harry Ostrera,h,2 Departments of aPathology, gMedicine, and hGenetics, Albert Einstein College of Medicine, Bronx, NY 10461; bDepartment of Computer Science, Columbia University, New York, NY 10027; cSusanne Levy Gertner Oncogenetics Unit, Danek Gertner Institute of Human Genetics, Chaim Sheba Medical Center, Tel- Hashomer 52621, Israel; dSackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel; eInstitute of Evolutionary Biology, Consejo Superior de Investigaciones Cientificas, Universitat Pompeu Fabra, 08003 Barcelona, Spain; fCochin Institute, Institut National de la Santé et de la Recherche Médicale 567, 75014 Paris, France; iCenter for Genome Informatics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101; and jDepartment of Genetics, Stanford University, Stanford, CA 94305 Edited* by Arno G. Motulsky, University of Washington, Seattle, WA, and approved July 3, 2012 (received for review March 23, 2012) North African Jews constitute the second largest Jewish Diaspora and Ethiopian Jews—groups that are thought to have limited group. However, their relatedness to each other; to European, Middle Eastern Jewish ancestry (15). Middle Eastern, and other Jewish Diaspora groups; and to their Previously, using genome-wide SNP and copy number varia- former North African non-Jewish neighbors has not been well tion data, we demonstrated that Sephardic (Greek and Turkish), defined.
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