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Liposomal D Supreme D and K for immune support and bone health using liposomal technology for superior absorption and bioavailability By David Brady, ND, DC, CCN, DACBN & Amy Berger, MS, CNS

THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATION IS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TO RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARY SUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT, DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION.

Liposomal D Supreme is a convenient and effective way to dose highly absorbable and bioavailable D for patients who need clinically relevant amounts and who may prefer to swallow fewer pills. Each 0.5 mL serving (approx. 1 pump) provides 2500 IU of vitamin D3 () along with in the K1 and K2 forms for synergistic bone health support. This liposomal formulation has a pleasant citrus flavor and is easy to titrate for higher doses.

Although it is classified as a vitamin, more closely resembles and functions like a steroid hormone with broad Liposomal D Supreme may be useful for: influences on physiology.1 Vitamin D is widely recognized as critical for a healthy immune system and strong bones, but its • Immune support functions go far beyond this, with many facets likely yet to be • Bone health identified and elucidated. For example, vitamin D helps regulate phosphorus balance, is needed for cell differentiation, and may • Brain development also play a role in insulin secretion.2 Vitamin D receptors are found • Cognitive function and balanced moods throughout the body and have been shown to influence the expression of thousands of genes.3,4 Vitamin D also plays a role in • Insulin secretion and glucoregulation the brain, influencing brain development in early life as well as • Healthy blood pressure brain function in adults, which may explain in part the associations between vitamin D deficiency, depressed moods and impaired cognition,5-9 and the improvements some patients report in these upon vitamin D supplementation.

Most holistically oriented health care practitioners aim for vitamin D blood levels (serum 25(OH)D) of between 50-100 ng/mL as optimal. However, vitamin D deficiency (a level ≤ 20 ng/mL) is Supplement Facts common, with epidemiological findings showing more than 40% of Serving Size 0.5 mL (approx. 1 pump) the US adult population to be deficient.10 Many patients will require Servings Per Container 100 a higher dose of vitamin D in order to achieve this. Amount Per Serving % Daily Value Several factors contribute to the high incidence of deficiency, such Vitamin D (as Cholecalciferol) 62.5 mcg (2500 IU) 313% as avoidance of sun exposure, older age (the elderly have reduced Vitamin K 325 mcg 271% capacity to synthesize vitamin D in skin upon exposure to UVB (as Vitamin K1 Phytonadione 200 mcg; radiation and are more likely to stay indoors or use sunscreen), Menaquinone-4 [MK-4] 100 mcg; chronic kidney disease, fat syndromes, inflammatory bowel conditions, and obesity.2 Individuals with darker skin color Vitamin K2 Menaquinone-7 [MK-7] 25 mcg) may be genetically adapted to require more sun exposure than those with lighter skin; African American and Hispanic American Other Ingredients: Water, glycerine, ethanol, (as tocofersolan and natural mixed individuals have higher rates of vitamin D deficiency compared to ), phospholipids (from sunflower lecithin), natural citrus oils. Caucasian Americans.10 Additionally, modern diets are typically - F ETAR IRY RE G IA A E E N V lower in vitamin D-rich foods that were once a more regular part of D

people’s diets, such as fatty fish, cod liver oil and lard from F F O A O A pastured pigs. R M U L R M U L

Vitamin D2 () is the form typically used in food fortification, but evidence indicates that D3 is far more effective for raising and maintaining serum 25(OH)D concentration, and that D2 should not be considered equivalent.11,12

ZTEC LPODSP 11/18 Why include vitamin K? Vitamin K is included in this formula, as it is essential for proper trafficking of calcium. Vitamin-K-dependent proteins orchestrate the deposition of calcium into bones and teeth while inhibiting vascular calcification. Increasing vitamin D levels via supplementation in the context of suboptimal vitamin K status may increase the risk of calcium deposition in arteries and soft tissue and have an adverse effect on arterial elasticity while simultaneously reducing bone mineralization, a situation known as “the calcification paradox” or “calcium paradox.”13,14 This imbalance between vitamins D and K explains individuals with both osteoporosis and vascular calcification. The strongest known inhibitor of tissue calcification is matrix Gla protein, which is vitamin-K-dependent,15,16 and osteocalcin, required for building and strengthening bone and dentin, is also vitamin K-dependent.

Liposomal D Supreme contains vitamin K as both K1 and K2. The effects of K2 are different from K1, which is better known for its influence on the clotting cascade. The body converts K1 to K2, but Structure of a Liposome this conversion may not occur optimally in all individuals. Intestinal bacteria also produce K2,17 but this may not be sufficient to meet the body’s needs.

What are liposomes? Liposomes are spheres made of phospholipids—the primary building blocks of cell membranes. Owing to this structure, liposomes bond easily with cell membranes to facilitate intracellular delivery of their nutrient cargo. Thanks to this enhanced delivery and absorption, nutrients delivered in liposomal form at lower doses may have equal or greater efficacy than higher doses provided in forms that are less bioavailable.

Designs for Health’s Liposomal D Supreme employs liposome particles that are 50-100nm in size, in contrast to 200- 600nm particles that are more commonly available from other manufacturers. The smaller sized particles result in increased oral and cellular uptake and faster transmucosal absorption in the mouth, in addition to enhanced absorption throughout the rest of the gastrointestinal tract. In fact, it is recommended to hold the product in the mouth for 30 seconds before swallowing to take advantage of this effective route of absorption. Additionally, clearance of these particles from the bloodstream (via the liver and spleen) is inversely related to size: the smallest particles circulate the longest, increasing the likelihood of absorption at their target tissues. Note that the phospholipids used in this product are derived from sunflower lecithin (soy-free, non-GMO material).

Benefits of Liposomal Delivery • Superior absorption and intracellular delivery of nutrients • Phospholipid structure allows for effective delivery of compounds with different solubilities carried within the same particle (e.g., water- and lipid-soluble compounds) • Liposomes penetrate the blood-brain barrier, an obstacle for other various formulations • While there is an opportunity for quick absorption in the mouth, liposomes also survive the acidic environment of the stomach, ensuring intestinal uptake and delivery to the lymphatic system • Liquid liposomal formulations are convenient for those who prefer to swallow fewer pills; also allow for easy dosing

Recommended Use: • As a dietary supplement, take 0.5 mL (approx. 1 pump) and hold in mouth for 30 seconds before swallowing, or as directed by your health care practitioner. • Due to the inclusion of vitamin K in this product, use caution when using Liposomal D Supreme with patients taking Coumadin, warfarin or other anticoagulant .

For a list of references cited in this document, please visit: http://catalog.designsforhealth.com/assets/itemresources/LiposomalDSupreme_References.pdf

To contact Designs for Health, please call us at (860) 623-6314, or visit us on the web at www.designsforhealth.com.

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