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Chapter 1 CHAPTER 2 1. “Management Of Chapter 1 CHAPTER 2 1. “Management of Substance Abuse”, World Health Organization, https://www.who.int/substance_abuse/facts/cannabis/en/ 2. Hui-Lin Li, “An Archaeological and Historical Account of Cannabis in China”, Economic Botany, Vol. 28, No. 4 (Oct. - Dec., 1974), pp. 437-448 3. Ren, M et al, “The origins of cannabis smoking: Chemical residue evidence from the first millennium BCE in the Pamirs”, Science Advances, 12 Jun 2019: Vol. 5, no. 6, eaaw1391 DOI: 10.1126/sciadv.aaw1391 4. Xiaozhai Lu and Robert C. Clarke, “The cultivation and use of hemp (Cannabis sativa L.) in ancient China” http://www.druglibrary.org/olsen/hemp/iha/iha02111.html 5. Ethan B. Russo, “History of Cannabis and Its Preparations in Saga, Science, and Sobriquet”, Chemistry and Biodiversity, 21 August 2007, https://doi.org/10.1002/cbdv.200790144 6. G.N. 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Masao Toyota et Al, “New Bibenzyl Cannabinoid from the New Zealand Liverwort Radula marginata”, Chemical and Pharmaceutical Bulletin, 2002, https://www.jstage.jst.go.jp/article/cpb/50/10/50_10_1390/_article/-char/ja/ 7. Lumír Ondřej Hanus, “Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids”, Medicinal Research Reviews, 05 September 2008 8. F Cullman, “Prenylated Bibenzyls from the Liverwort Radula laxiramea”, A Journal of Biosciences, Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-1999-3-401 9. JuditHohmann et Al, “Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors”, Phytochemistry, Volume 72, Issues 14–15, October 2011, Pages 1848-1853 10. JÜRG GERTSCH, “New Natural Noncannabinoid Ligands for Cannabinoid Type- 2 (CB2) Receptors”, Journal of Receptors and Signal Transduction, Volume 26, 2006 - Issue 5-6 11. Belén Palomares et al, Tetrahydrocannabinolic Acid a (THCA-A) Reduces Adiposity and Prevents Metabolic Disease Caused by Diet-Induced Obesity, Biochemical Pharmacology doi: 10.1016/j.bcp.2019.113693 12. Pagano E, et al. The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsiesfrom UC pediatric patients. Pharmacol Res. 2019 Nov;149:104464. doi:10.1016/j.phrs.2019.104464. Epub 2019 Sep 22. PubMed PMID: 31553934. 13. Joana Gonçalves et Al, “Cannabis and Its Secondary Metabolites: Their Use as Therapeutic Drugs, Toxicological Aspects, and Analytical Determination”, Medicines (Basel). 2019 Mar; 6(1): 31 14. F.DegenhardtF.StehleO.Kayser , “Chapter 2 - The Biosynthesis of Cannabinoids”, Handbook of Cannabis and Related Pathologies, 2017, Pages 13-23 15. Russo EB1, Marcu J2. , “Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads”, Adv Pharmacol. 2017;80:67-134 16. Russo E, “Cannabidiol Claims and Misconceptions”, Trends in Pharmacological Sciences 38(3) · January 2017 17. Ethan B Russo, Taming THC: potential cannabis synergy and phytocannabinoid- terpenoid entourage effects, Br J Pharmacol. 2011 Aug; 163(7): 1344–1364. 18. Adams TB, Taylor SV. Safety evaluation of essential oils: a constituent-based approach. In: Baser KHC, Buchbauer G, editors. Handbook of Essential Oils: Science, Technology, and Applications. Boca Raton, FL: CRC Press; 2010. pp. 185–208 19. Buchbauer G et Al, Fragrance compounds and essential oils with sedative effects upon inhalation, J Pharm Sci. 1993 Jun;82(6):660-4. 20. Viola Brugnatelli, Anti-inflammatory & anti-nociceptive properties of β-myrcene, https://www.fundacion-canna.es/en/anti-inflammatory-anti-nociceptive-properties- v-myrcene 21. Lewis MA1, Russo EB2, Smith KM1, Pharmacological Foundations of Cannabis Chemovars, Planta Med. 2018 Mar;84(4):225-233 22. 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Philippe Henry PhD , Cannabis chemovar classification: terpenes hyper-classes and targeted genetic markers for accurate discrimination of flavours and effects, https://peerj.com/preprints/3307.pdf 34. Sawler J, Stout JM, Gardner KM, et al. The Genetic Structure of Marijuana and Hemp. PLoS One. 2015;10(8):e0133292. Published 2015 Aug 26. doi:10.1371/journal.pone.0133292 Chapter 4 1. Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med. 2006 Feb;27(1):1-93. Epub 2005 Aug 18. Review. PubMed PMID: 16105678) 2. Basavarajappa BS. Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms,
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