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The Handbook of Cannabis Therapeutics: from Bench to Bedside
Handbook of Cannabis Therapeutics From Bench to Bedside 9780789030979 Handbook of Cannabis Therapeutics From Bench to Bedside Size: 212 x 152mm Spine size: 26 mm Color pages: Binding: Paperback THE HAWORTH PRESS® Haworth Series in Integrative Healing Ethan Russo Editor The Last Sorcerer: Echoes of the Rainforest by Ethan Russo Professionalism and Ethics in Complementary and Alternative Medicine by John Crellin and Fernando Ania Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential by Franjo Grotenhermen and Ethan Russo Modern Psychology and Ancient Wisdom: Psychological Healing Practices from the World’s Religious Traditions edited by Sharon G. Mijares Complementary and Alternative Medicine: Clinic Design by Robert A. Roush Herbal Voices: American Herbalism Through the Words of American Herbalists by Anne K. Dougherty The Healing Power of Chinese Herbs and Medicinal Recipes by Joseph P. Hou and Youyu Jin Alternative Therapies in the Treatment of Brain Injury and Neurobehavioral Disorders: A Practical Guide edited by Gregory J. Murrey Handbook of Cannabis Therapeutics: From Bench to Bedside edited by Ethan B. Russo and Franjo Grotenhermen Handbook of Cannabis Therapeutics From Bench to Bedside Ethan B. Russo, MD Franjo Grotenhermen, MD Editors Routledge Taylor &. Francis Croup NEW YORK AND LONDON First Published by The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580. Transferred to Digital Printing 2010 by Routledge 270 Madison Ave, New York NY 10016 2 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN For more information on this book or to order, visit http://www.haworthpress.com/store/product.asp?sku=5741 or call 1-800-HAWORTH (800-429-6784) in the United States and Canada or (607) 722-5857 outside the United States and Canada or contact [email protected] © 2006 by The Haworth Press, Inc. -
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This article was downloaded by: [Retallack, Gregory J.] On: 2 November 2009 Access details: Access Details: [subscription number 916429953] Publisher Taylor & Francis Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK Alcheringa: An Australasian Journal of Palaeontology Publication details, including instructions for authors and subscription information: http://www.informaworld.com/smpp/title~content=t770322720 Cambrian-Ordovician non-marine fossils from South Australia Gregory J. Retallack a a Department of Geological Sciences, University of Oregon, Eugene, OR, USA Online Publication Date: 01 December 2009 To cite this Article Retallack, Gregory J.(2009)'Cambrian-Ordovician non-marine fossils from South Australia',Alcheringa: An Australasian Journal of Palaeontology,33:4,355 — 391 To link to this Article: DOI: 10.1080/03115510903271066 URL: http://dx.doi.org/10.1080/03115510903271066 PLEASE SCROLL DOWN FOR ARTICLE Full terms and conditions of use: http://www.informaworld.com/terms-and-conditions-of-access.pdf This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, re-distribution, re-selling, loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. -
The Epic History of Biology20
Lthrary of Congreea Catalogtng—ln—Publ cat ion Date IntO Anthon.,. The Cplc of b10109y Anthony Serefln*. p. Ca. Titciudet bibI referencea and 0-306-44511-5 1. Blology——P4scry. 2. liedtctne-—HIsto'y. 3. 8'olog'%ts. 4. Medical sclen'tstS. Titi,. 1993 93-27895 574 .09-—0c2) CIP 0-7382-0577-X tO987 6 5 4 01993Anthony Serafini Published by Perseus Publishing, A Member of the Perseus Books Group. All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying. microfilming, recording. or otherwise, without written permission from the Publisher Printedin the United States of America Contents CRAMER 1. THE BEGINNINGS I CHAP1ER2. MESOFUTAMIA 9 ClIAFTER3. GREEK MFDKINF CHAPTER4. ROME 45 CHAI1FER5. IFIE MIDDLE AGES 55 CHArFER 6. Fl IF 54 Cl IAVIER 7. PEST II ENCE IN THE RENAISSANCE 69 CHAPTER 8. TI-Ui AGE('IVESAIIIJS 75 CHAPTER 4 TIlE HARVEYt RA 89 Lx x Contents CHAPTER 10. THE AGE OF NEWTON 703 CHAPTER11. THE MICROSCOPE AND LEEUWENI-IOEIC 117 CHAPTER12. THE MEETING OF BEOWGY AND CHEMISTRY 177 CHAPTER 13. RAY AND THE EMERGENCE OF CELL ThEORY 125 CHAPTER THE AGE OF UNNAEUS AND 11IE ENLIGHTENMENT 139 CHAPTER15. LAMARCIC AND HIS SYSTEM 17! CHAPTER16. TI IF RiSE OF PALEONTOLOGY CHAPTER 17. BIOWGY IN THE VJCTORIAN ERA 195 CHAPTER 18. DARWIN AND HIS AGE 209 CHAPTER19. EMBRYOLOGY AND BIOCHEMISTRY IN THE DARWINIAN ERA 233 CHAPTER 20. THE AGE OF PASTEUR AND THE DEVELOPMENT OF THE MICROSCOPE 249 CHAPTER21. BIOLOGY IN THE TWENTIETH CENTURY 269 CHAE'TLR 22. -
Advances in Photosynthesis and Respiration, Volume 23: Structure and Function of Plastids
Photosynth Res (2006) 89:173–177 DOI 10.1007/s11120-006-9070-z ANNOUNCEMENT Advances in Photosynthesis and Respiration, Volume 23: Structure and Function of Plastids Govindjee Published online: 8 July 20061 Ó Springer Science+Business Media B.V. 2006 I am delighted to announce the publication, in Ad- Volume1: Molecular Biology of Cyanobacteria (28 vances in Photosynthesis and Respiration (AIPH) Chapters; 881 pages; 1994; edited by Donald A. Bryant, Series, of The Structure and Function of Plastids,a from USA; ISBN: 0-7923-3222-9); book covering the central role of plastids for life on Volume 2: Anoxygenic Photosynthetic Bacteria (62 earth. It deals with both the structure and the func- Chapters; 1331 pages; 1995; edited by Robert tion of these unique organelles, particularly of chlo- E. Blankenship, Michael T. Madigan, and Carl E. roplasts. Two distinguished authorities have edited Bauer, from USA; ISBN: 0-7923-3682-8); this volume: Robert R. Wise of the University of Volume 3: Biophysical Techniques in Photosynthesis Wisconsin at Oshkosh, Wisconsin, and J. Kenneth (24 Chapters; 411 pages; 1996; edited by the late Jan Hoober of the Arizona State University, Tempe, Amesz and the late Arnold J. Hoff, from The Arizona. Two of the earlier AIPH volumes have in- Netherlands; ISBN: 0-7923-3642-9); cluded descriptions of plastids: Volume 7 (The Volume 4: Oxygenic Photosynthesis: The Light Molecular Biology of Chloroplasts and Mitochondria Reactions (34 Chapters; 682 pages; 1996; edited by in Chlamydomonas, edited by Jean-David Rochaix, Donald R. Ort and Charles F. Yocum, from USA; Michel Goldschmidt-Clermont and Sabeeha Mer- ISBN: 0-7923-3683-6); chant); and Volume 14 (Photosynthesis in Algae, Volume 5: Photosynthesis and the Environment (20 edited by Anthony Larkum, Susan Douglas, and John Chapters; 491 pages; 1996; edited by Neil R. -
A Symbiosis with Fungi?
BIO Web of Conferences 4, 00009 (2015) DOI: 10.1051/bioconf/20150400009 C Owned by the authors, published by EDP Sciences, 2015 Origins of the terrestrial flora: A symbiosis with fungi? Marc-André Selosse1,a and Christine Strullu-Derrien2 1 Institut de Systématique, Évolution, Biodiversité (ISYEB - UMR 7205 – CNRS, MNHN, UPMC, EPHE), Muséum national d’Histoire naturelle, Sorbonne Universités, 57 rue Cuvier, CP. 50, 75005 Paris, France 2 Department of Earth Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD, UK Abstract. Land phototrophs need to exploit both atmosphere (providing gas and light) and substrate (furnishing water and minerals). Yet, their algal ancestors were poorly pre- adapted to such a life at the interface. We review the paleontological evidence that fungal symbioses which can exploit substrate resources, helped adaptation to land constraints. Diverse structures dating back to the Devonian present convincing evidence for lichens, (symbioses between fungi and microscopic algae) but fossils remain scarce, so that early lichen abundance and ecological relevance remain questionable. Several enigmatic but abundant fossils from the Siluro-Devonian, such as Spongiophyton or the giant Prototaxites (Nematophytes), likely represent fungus-algal symbioses, which shaped early terrestrial ecosystems. Yet, these taxa are fully extinct, and do not have clear affinities with extant groups. Finally, terrestrialization of Embryophyta (land plants), which currently dominate land ecosystems, is linked to a symbiosis with Glomeromycetes. Today, these fungi form arbuscular mycorrhizae, which help most Embryophyta to exploit soil, and molecular data combined with paleontological evidence support the idea that this type of association is ancestral. The role of symbiotic Mucoromycetes during terrestrialization is not fully understood and mycorrhizal association diversified later in the evolution of Embryophyta. -
REVIEW History of Cannabis and Its Preparations in Saga, Science, And
1614 CHEMISTRY & BIODIVERSITY – Vol. 4 (2007) REVIEW History of Cannabis and Its Preparations in Saga, Science, and Sobriquet by Ethan B. Russo 20402 81st Avenue SW, Vashon, WA 98070, USA (e-mail: [email protected]) Cannabis sativa L. is possibly one of the oldest plants cultivated by man, but has remained a source of controversy throughout its history. Whether pariah or panacea, this most versatile botanical has provided a mirror to medicine and has pointed the way in the last two decades toward a host of medical challenges from analgesia to weight loss through the discovery of its myriad biochemical attributes and the endocannabinoid system wherein many of its components operate. This study surveys the history of cannabis, its genetics and preparations. A review of cannabis usage in Ancient Egypt will serve as an archetype, while examining first mentions from various Old World cultures and their pertinence for contemporary scientific investigation. Cannabis historians of the past have provided promising clues to potential treatments for a wide array of currently puzzling medical syndromes including chronic pain, spasticity, cancer, seizure disorders, nausea, anorexia, and infectious disease that remain challenges for 21st century medicine. Information gleaned from the history of cannabis administration in its various forms may provide useful points of departure for research into novel delivery techniques and standardization of cannabis-based medicines that will allow their prescription for treatment of these intractable medical conditions. Contents 1. Introduction 2. The Ticklish Matter of Taxonomy 3. A Bit of Geography 4. Cannabis Preparations: Bhang, Ganja, and Charas 5. History of Medicinal Cannabis 5.1. -
ABHANDLUNGEN DER GEOLOGISCHEN BUNDESANSTALT Abh
©Geol. Bundesanstalt, Wien; download unter www.geologie.ac.at ABHANDLUNGEN DER GEOLOGISCHEN BUNDESANSTALT Abh. Geol. B.-A. ISSN 0016–7800 ISBN 3-85316-02-6 Band 54 S. 323–335 Wien, Oktober 1999 North Gondwana: Mid-Paleozoic Terranes, Stratigraphy and Biota Editors: R. Feist, J.A. Talent & A. Daurer Plants Associated with Tentaculites in a New Early Devonian Locality from Morocco PHILIPPE GERRIENNE, MURIEL FAIRON-DEMARET, JEAN GALTIER, HUBERT LARDEUX, BRIGITTE MEYER-BERTHAUD, SERGE RÉGNAULT & PHILIPPE STEEMANS*) 4 Text-Figures, 2 Tables and 2 Plates Morocco Devonian Plants Miospores Systematics Tentaculites Palaeogeography Contents Zusammenfassung ...................................................................................................... 323 Abstract ................................................................................................................. 324 1. Introduction ............................................................................................................. 324 2. Materials and Methods ................................................................................................... 324 3. Description of the Tentaculite Assemblage ................................................................................ 325 4. Description of the Miospore Assemblage ................................................................................. 325 5. Description of the Plant Assemblage ...................................................................................... 326 5. 1. Pachytheca sp....................................................................................................... -
Uncovering the Psychoactivity of a Cannabinoid from Liverworts Associated with a Cyano Cannabinoids
SCIENCE ADVANCES | RESEARCH ARTICLE NEUROPHYSIOLOGY Copyright © 2018 The Authors, some rights reserved; Uncovering the psychoactivity of a cannabinoid from exclusive licensee American Association liverworts associated with a legal high for the Advancement A. Chicca1, M. A. Schafroth2, I. Reynoso-Moreno1, R. Erni2, V. Petrucci1, of Science. No claim to 2 1 original U.S. Government E. M. Carreira *, J. Gertsch * Works. Distributed under a Creative Phytochemical studies on the liverwort Radula genus have previously identified the bibenzyl (−)-cis-perrottetinene Commons Attribution 9 9 (cis-PET), which structurally resembles (−)-D -trans-tetrahydrocannabinol (D -trans-THC) from Cannabis sativa NonCommercial L. Radula preparations are sold as cannabinoid-like legal high on the internet, even though pharmacological data License 4.0 (CC BY-NC). are lacking. Herein, we describe a versatile total synthesis of (−)-cis-PET and its (−)-trans diastereoisomer and demonstrate that both molecules readily penetrate the brain and induce hypothermia, catalepsy, hypolocomo- tion, and analgesia in a CB1 receptor–dependent manner in mice. The natural product (−)-cis-PET was profiled on major brain receptors, showing a selective cannabinoid pharmacology. This study also uncovers pharmacological 9 differences between D -THC and PET diastereoisomers. Most notably, (−)-cis-PET and (−)-trans-PET significantly 9 reduced basal brain prostaglandin levels associated with D -trans-THC side effects in a CB1 receptor–dependent manner, thus mimicking the action of the endocannabinoid 2-arachidonoyl glycerol. Therefore, the natural product (−)-cis-PET is a psychoactive cannabinoid from bryophytes, illustrating the existence of convergent evolution of bioactive cannabinoids in the plant kingdom. Our findings may have implications for bioprospecting and drug discovery and provide a molecular rationale for the reported effects upon consumption of certain Radula prepa- rations as moderately active legal highs. -
Integrative Taxonomy Resolves the Cryptic and Pseudo-Cryptic Radula Buccinifera Complex (Porellales, Jungermanniopsida), Including Two Reinstated and Five New Species
A peer-reviewed open-access journal PhytoKeys 27:Integrative 1–113 (2013) taxonomy resolves the cryptic and pseudo-cryptic Radula buccinifera... 1 doi: 10.3897/phytokeys.27.5523 RESEARCH ARTICLE www.phytokeys.com Launched to accelerate biodiversity research Integrative taxonomy resolves the cryptic and pseudo-cryptic Radula buccinifera complex (Porellales, Jungermanniopsida), including two reinstated and five new species Matt A.M. Renner1, Nicolas Devos2, Jairo Patiño3, Elizabeth A. Brown1, Andrew Orme1, Michael Elgey1, Trevor C. Wilson1, Lindsey J. Gray4, Matt J. von Konrat5 1 Royal Botanic Gardens and Domain Trust, Mrs Macquaries Road, Sydney, NSW 2000, Australia 2 Department of Biology, Duke University, Box 90388, Durham NC 27708, U.S.A. 3 Institute of Botany, University of Liège, Liège, Belgium 4 School of Biological Sciences, The University of Sydney, NSW 2006, Australia 5 The ieldF Mu- seum of Natural History, 1400 South Lake Shore Drive, Chicago, Illinois, USA Corresponding author: Matt A.M. Renner ([email protected]) Academic editor: Lyubomir Penev | Received 15 May 2013 | Accepted 20 August 2013 | Published 30 October 2013 Citation: Renner MAM, Devos N, Patiño J, Brown EA, Orme A, Elgey M, Wilson TC, Gray LJ, von Konrat MJ (2013) Integrative taxonomy resolves the cryptic and pseudo-cryptic Radula buccinifera complex (Porellales, Jungermanniopsida), including two reinstated and five new species. PhytoKeys 27: 1–113. doi: 10.3897/phytokeys.27.5523 Abstract Molecular data from three chloroplast markers resolve individuals attributable to Radula buccinifera in six lineages belonging to two subgenera, indicating the species is polyphyletic as currently circumscribed. All lineages are morphologically diagnosable, but one pair exhibits such morphological overlap that they can be considered cryptic. -
Metabolic Engineering of Cannabinoid Biosynthesis in Tobacco
Metabolic engineering of cannabinoid biosynthesis in tobacco Vom Fachbereich Biologie der Technischen Universität Darmstadt zur Erlangung des akademischen Grades Doctor rerum naturalium genehmigte Dissertation von M. Sc. Marcus Frank Geißler aus Höchst im Odenwald 1. Referent: Prof. Dr. Heribert Warzecha 2. Referent: Prof. Dr. Adam Bertl Darmstadt 2021 Geißler, Marcus Frank: Metabolic engineering of cannabinoid biosynthesis in tobacco Darmstadt, Technische Universität Darmstadt Jahr der Veröffentlichung der Dissertation auf TUprints: 2021 Tag der mündlichen Prüfung: 11.06.2021 Veröffentlichung unter CC BY-SA 4.0 International https://creativecommons.org/licenses/ 2 Für Jana 4 Abstract For millennia, Cannabis has been used in various cultural groups because of its versatile applications. Among other things, the plant served as a source of textile fibers, but was also used as a medicine to treat inflammation, cramps or epilepsy. With the discovery of the endocannabinoid system, the plant, which had fallen into disrepute in the mid-20th century because of its excessive use as a recreational drug and is therefore still subject to heavy restrictions in most countries, gained new prestige. Thus, it was found that certain secondary metabolites, known as cannabinoids, could modulate a variety of physiological processes, potentially offering new therapeutic applications. To date, more than 100 of these cannabinoids have been isolated, the best known of which are the psychoactive-acting Δ9-tetrahydrocannabinol (THC) and the non-psychotropic cannabidiol (CBD). In this context, THC- and CBD-containing products such as Sativex® and Epidyolex®, which are already approved as pharmaceuticals, are finding application in medicine. However, THC is considered a major limitation for clinical use due to its psychoactive character, so non-psychotropic cannabinoids, as well as synthetic non-naturally-occurring cannabinoids that have similar medicinal properties to THC, but do not have the undesirable side effect, will be of key importance in the future. -
Ob Dir Es Sauer Wird Mit Deiner Nahrung Und Ackerwerk, Das Laß Dich Nicht Verdrießen, Denn Gott Hat Es Also Geschaffen“
er aus Westfalen stammende Gottfried Dietrich Wilhelm Berthold (1854- Katharina Ruttig, Thomas Friedl, 1937) ist als Botaniker des 19. und beginnenden 20. Jahrhunderts eng mit Dder Geschichte der Georgia Augusta in Göttingen verwoben. Er hatte sich be- Volker Wissemann reits als Student an der Universität Göttingen mit Algen beschäftigt und sei- ne Dissertation dieser Thematik gewidmet. Nach Forschungsaufenthalten an der Zoologischen Station in Neapel, wo er intensiv Untersuchungen an Algen „Ob Dir es sauer wird mit durchführte, habilitierte er sich 1881 in Göttingen bei Johannes Reinke. Spä- ter übernahm er dessen Professur für Botanik sowie dessen Direktorat am Deiner Nahrung und Ackerwerk, Pflanzenphysiologischen Institut und widmete sich entwicklungsmechanischen das laß Dich nicht verdrießen, bzw. physiologischen Fragen bei höheren Pflanzen. Die vorliegende Mono- grafie untersucht erstmalig anhand der gegenwärtigen Forschungslage Leben denn Gott hat es also geschaffen“ und Wirken Bertholds. Bertholds Lebensgeschichte wird chronologisch und in größtmöglicher Vollständigkeit dargestellt. Bildungsgeschichtliche Akzente, der personelle Konnex zu Johannes Reinke und der Einfluss der Zoologischen Gottfried Dietrich Wilhelm Berthold (1854-1937) Station Neapel finden hier ebenso Platz wie die Rekonstruktion der Lehr- und Forschungstätigkeiten und der familiären Verhältnisse. Da Berthold vorrangig Ein Beitrag zur Geschichte der Biologie als Phykologe, also Algenkundler anzusehen ist, widmet sich der zweite Teil an der Georgia Augusta Göttingen -
Cumulative Bibliography on the History of Oceanography, 1987
CUMULATIVE BIBLIOGRAPHY ON THE HISTORY OF OCEANOGRAPHY, 1987- The Cumulative Bibliography on the History of Oceanography (CBHO) was published annually in the History of Oceanography Newsletter beginning in 1987 and through 1997, in order to gather in one place the scattered literature on the history of oceanography. CBHO strives to list all works on the history of oceanography. Biographical items like biographies and obituaries are compiled separately. CBHO was compiled from 1987 to 1997 by Jacqueline Carpine-Lancre, Librarian of the Musee Oceanographique in Monaco and Secretary of the Commission of Oceanography of the International Union of the History and Philosophy of Science, Division of History of Science. More recent citations are being compiled by Deborah Day, Scripps Institution of Oceanography Archivist, and are listed at the end of this bibliography (not interspersed throughout the initial alphabetical arrangement.) CBHO includes all works on the history of oceanography, except biographical items like biographies and obituaries. There is no comprehensive bibliography on the history of oceanography before 1987. CBHO was compiled from many sources including: • Oceanographic Literature Review (part B of Deep-Sea Research), Section F.330: History of Science (especially Oceanography); • Aquatic Sciences and Fisheries Abstracts, Section: History and Development; • Bulletin Signaletique, 522: Histoire des Sciences et des Techniques, V.B.: Geophysique, Oceanographie; • Isis (critical bibliography), Section HS.23c: Oceanography. • documents received in the libraries of the Musee Oceanographique de Monaco & of the International Hydrographic Bureau, as well as SIO Archives • items sent to Jacqueline Carpine-Lancre and Deborah Day by authors, librarians & book reviewers throughout the world. The format has been changed to the style cited in The Chicago Manual of Style (14th ed., 1993).