Mitochondrial DNA Haplogroups Observed in Iraqi Population
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Germanic Origins from the Perspective of the Y-Chromosome
Germanic Origins from the Perspective of the Y-Chromosome By Michael Robert St. Clair A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor in Philosophy in German in the Graduate Division of the University of California, Berkeley Committee in charge: Irmengard Rauch, Chair Thomas F. Shannon Montgomery Slatkin Spring 2012 Abstract Germanic Origins from the Perspective of the Y-Chromosome by Michael Robert St. Clair Doctor of Philosophy in German University of California, Berkeley Irmengard Rauch, Chair This dissertation holds that genetic data are a useful tool for evaluating contemporary models of Germanic origins. The Germanic languages are a branch of the Indo-European language family and include among their major contemporary representatives English, German, Dutch, Danish, Swedish, Norwegian and Icelandic. Historically, the search for Germanic origins has sought to determine where the Germanic languages evolved, and why the Germanic languages are similar to and different from other European languages. Both archaeological and linguist approaches have been employed in this research direction. The linguistic approach to Germanic origins is split among those who favor the Stammbaum theory and those favoring language contact theory. Stammbaum theory posits that Proto-Germanic separated from an ancestral Indo-European parent language. This theoretical approach accounts for similarities between Germanic and other Indo- European languages by posting a period of mutual development. Germanic innovations, on the other hand, occurred in isolation after separation from the parent language. Language contact theory posits that Proto-Germanic was the product of language convergence and this convergence explains features that Germanic shares with other Indo-European languages. -
ZEYLANICA a Study of the Peoples and Languages of Sri Lanka
ZEYLANICA A Study of the Peoples and Languages of Sri Lanka Asiff Hussein Second Edition: September 2014 ZEYLANICA. A Study of the Peoples and Languages of Sri Lanka ISBN 978-955-0028-04-7 © Asiff Hussein Printed by: Printel (Pvt) Ltd 21/11, 4 th Lane, Araliya Uyana Depanama, Pannipitiya Published by: Neptune Publications CONTENTS Chapter 1 Legendary peoples of Lanka Chapter 2 The Veddas, the aboriginal inhabitants of Lanka and their speech Chapter 3 The Origins of the Sinhalese nation and the Sinhala language Chapter 4 The Origins of the Sri Lankan Tamils and the Tamil language Chapter 5 The Sri Lankan Moors and their language Chapter 6 The Malays of Sri Lanka and the local Malay language Chapter 7 The Memons, a people of North Indian origin and their language Chapter 8 Peoples of European origin. The Portuguese and Dutch Burghers Chapter 9 The Kaffirs. A people of African origin Chapter 10 The Ahikuntaka. The Gypsies of Sri Lanka INTRODUCTORY NOTE The system of transliteration employed in the text, save for citations, is the standard method. Thus dots below letters represent retroflex sounds which are pronounced with the tip of the tongue striking the roof of the mouth further back than for dental sounds which are articulated by placing the tip of the tongue against the upper front teeth. Among the other sounds transliterated here c represents the voiceless palato-alveolar affricate (as sounded in the English church ) and ś the palatal sibilant (as sounded in English sh ow ). The lingual which will be found occurring in Sanskrit words is similar in pronunciation to the palatal . -
Y-Chromosome and Mtdna Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations
Y-Chromosome and mtDNA Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Badro, Danielle A., Bouchra Douaihy, Marc Haber, Sonia C. Youhanna, Angélique Salloum, Michella Ghassibe-Sabbagh, Brian Johnsrud, et al. 2013. Y-chromosome and mtDNA genetics reveal significant contrasts in affinities of modern Middle Eastern populations with European and African populations. PLoS ONE 8(1): e54616. Published Version doi:10.1371/journal.pone.0054616 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:10613666 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Y-Chromosome and mtDNA Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations Danielle A. Badro1, Bouchra Douaihy1., Marc Haber1,2., Sonia C. Youhanna1, Ange´lique Salloum1, Michella Ghassibe-Sabbagh1, Brian Johnsrud3, Georges Khazen1, Elizabeth Matisoo-Smith4, David F. Soria-Hernanz2,5, R. Spencer Wells5, Chris Tyler-Smith6, Daniel E. Platt7, Pierre A. Zalloua1,8*, The Genographic Consortium" 1 The Lebanese American University, Chouran, Beirut, Lebanon, 2 Institut de Biologia Evolutiva (CSIC-UPF), Departament -
The Genetic Landscape of Mediterranean North African Populations Through Complete Mtdna Sequences
Annals of Human Biology ISSN: 0301-4460 (Print) 1464-5033 (Online) Journal homepage: http://www.tandfonline.com/loi/iahb20 The genetic landscape of Mediterranean North African populations through complete mtDNA sequences Neus Font-Porterias, Neus Solé-Morata, Gerard Serra-Vidal, Asmahan Bekada, Karima Fadhlaoui-Zid, Pierre Zalloua, Francesc Calafell & David Comas To cite this article: Neus Font-Porterias, Neus Solé-Morata, Gerard Serra-Vidal, Asmahan Bekada, Karima Fadhlaoui-Zid, Pierre Zalloua, Francesc Calafell & David Comas (2018) The genetic landscape of Mediterranean North African populations through complete mtDNA sequences, Annals of Human Biology, 45:1, 98-104, DOI: 10.1080/03014460.2017.1413133 To link to this article: https://doi.org/10.1080/03014460.2017.1413133 View supplementary material Published online: 30 Jan 2018. Submit your article to this journal View related articles View Crossmark data Citing articles: 1 View citing articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=iahb20 ANNALS OF HUMAN BIOLOGY, 2018 VOL. 45, NO. 1, 98–104 https://doi.org/10.1080/03014460.2017.1413133 RESEARCH PAPER The genetic landscape of Mediterranean North African populations through complete mtDNA sequences Neus Font-Porteriasa, Neus Sole-Morata a, Gerard Serra-Vidala, Asmahan Bekadab, Karima Fadhlaoui-Zidc, Pierre Zallouad, Francesc Calafella and David Comasa aDepartament de Ciencies Experimentals i de la Salut, Institute of Evolutionary Biology (CSIC-UPF), Universitat -
Introducing the Algerian Mitochondrial DNA and Y- Chromosome Profiles Into the North African Landscape
Introducing the Algerian Mitochondrial DNA and Y- Chromosome Profiles into the North African Landscape Asmahan Bekada1, Rosa Fregel2,3,4, Vicente M. Cabrera2, Jose´ M. Larruga2, Jose´ Pestano3,4, Soraya Benhamamouch1, Ana M. Gonza´lez2* 1 Department of Biotechnology, Faculty of Sciences, University of Oran, Oran, Algeria, 2 Department of Genetics, Faculty of Biology, University of La Laguna, La Laguna, Tenerife, Spain, 3 Department of Genetics, Faculty of Medicine, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Gran Canaria, Spain, 4 Forensic Genetics Laboratory, Institute of Legal Medicine of Las Palmas, Las Palmas de Gran Canaria, Gran Canaria, Spain Abstract North Africa is considered a distinct geographic and ethnic entity within Africa. Although modern humans originated in this Continent, studies of mitochondrial DNA (mtDNA) and Y-chromosome genealogical markers provide evidence that the North African gene pool has been shaped by the back-migration of several Eurasian lineages in Paleolithic and Neolithic times. More recent influences from sub-Saharan Africa and Mediterranean Europe are also evident. The presence of East- West and North-South haplogroup frequency gradients strongly reinforces the genetic complexity of this region. However, this genetic scenario is beset with a notable gap, which is the lack of consistent information for Algeria, the largest country in the Maghreb. To fill this gap, we analyzed a sample of 240 unrelated subjects from a northwest Algeria cosmopolitan population using mtDNA sequences and Y-chromosome biallelic polymorphisms, focusing on the fine dissection of haplogroups E and R, which are the most prevalent in North Africa and Europe respectively. -
HUMAN MITOCHONDRIAL DNA HAPLOGROUP J in EUROPE and NEAR EAST M.Sc
UNIVERSITY OF TARTU FACULTY OF BIOLOGY AND GEOGRAPHY, INSTITUTE OF MOLECULAR AND CELL BIOLOGY, DEPARTMENT OF EVOLUTIONARY BIOLOGY Piia Serk HUMAN MITOCHONDRIAL DNA HAPLOGROUP J IN EUROPE AND NEAR EAST M.Sc. Thesis Supervisors: Ph.D. Ene Metspalu, Prof. Richard Villems Tartu 2004 Table of contents Abbreviations .............................................................................................................................3 Definition of basic terms used in the thesis.........................................................................3 Introduction................................................................................................................................4 Literature overview ....................................................................................................................5 West–Eurasian mtDNA tree................................................................................................5 Fast mutation rate of mtDNA..............................................................................................9 Estimation of a coalescence time ......................................................................................10 Topology of mtDNA haplogroup J....................................................................................12 Geographic spread of mtDNA haplogroup J.....................................................................20 The aim of the present study ....................................................................................................22 -
Ancient Mitochondrial DNA from Pre-Historic
Grand Valley State University ScholarWorks@GVSU Masters Theses Graduate Research and Creative Practice 4-30-2011 Ancient Mitochondrial DNA From Pre-historic Southeastern Europe: The rP esence of East Eurasian Haplogroups Provides Evidence of Interactions with South Siberians Across the Central Asian Steppe Belt Jeremy R. Newton Grand Valley State University Follow this and additional works at: http://scholarworks.gvsu.edu/theses Part of the Cell Biology Commons, and the Molecular Biology Commons Recommended Citation Newton, Jeremy R., "Ancient Mitochondrial DNA From Pre-historic Southeastern Europe: The rP esence of East Eurasian Haplogroups Provides Evidence of Interactions with South Siberians Across the Central Asian Steppe Belt" (2011). Masters Theses. 5. http://scholarworks.gvsu.edu/theses/5 This Thesis is brought to you for free and open access by the Graduate Research and Creative Practice at ScholarWorks@GVSU. It has been accepted for inclusion in Masters Theses by an authorized administrator of ScholarWorks@GVSU. For more information, please contact [email protected]. ANCIENT MITOCHONDRIAL DNA FROM PRE-HISTORIC SOUTH- EASTERN EUROPE: THE PRESENCE OF EAST EURASIAN HAPLOGROUPS PROVIDES EVIDENCE OF INTERACTIONS WITH SOUTH SIBERIANS ACROSS THE CENTRAL ASIAN STEPPE BELT A thesis submittal in partial fulfillment of the requirements for the degree of Master of Science By Jeremy R. Newton To Cell and Molecular Biology Department Grand Valley State University Allendale, MI April, 2011 “Not all those who wander are lost.” J.R.R. Tolkien iii ACKNOWLEDGEMENTS I would like to extend my sincerest thanks to every person who has motivated, directed, and encouraged me throughout this thesis project. I especially thank my graduate advisor, Dr. -
Y-Chromosome & Mitochondrial DNA Variation
The Genetic Structure of the Kuwaiti and Failaka Island Populations: Y-chromosome & Mitochondrial DNA Variation By Jasem Bader Theyab M.A., University of Kansas, 2010 Copyright 2013 Submitted to the graduate degree program in Anthropology and the Graduate Faculty of the University of Kansas in partial fulfillment of the requirements for the degree of Doctor of Philosophy. ________________________________ Chairperson, Dr. Michael H. Crawford ________________________________ Dr. Majid Hannoum ________________________________ Dr. Deborah Smith ________________________________ Dr. Bartholomew C. Dean ________________________________ Dr. John Kelly Date Defended: May 28, 2013 The Dissertation Committee for Jasem Bader Theyab certifies that this is the approved version of the following dissertation: The Genetic Structure of the Kuwaiti and Failaka Island Populations: Y-chromosome & Mitochondrial DNA Variation ________________________________ Chairperson, Dr. Michael H. Crawford Date approved: May 31, 2013 ii Abstract Recent studies applying multidisciplinary approaches suggest that the Anatomically Modern Homo sapiens (AMHS) passed through the Arabian Peninsula in their major diaspora out of Africa. The Arabian Peninsula is connected to three continents: Africa, Asia, and Europe. In addition to the major diaspora, the Arabian Peninsula has witnessed numerous migrations among the three continents. The populations of the Arabian Peninsula have been investigated to better understand their evolutionary history. This dissertation investigated the paternal genetic structure of the Kuwaiti and Failaka Island populations using 15 loci Y-STR data. In addition, the maternal genetic structure of Failaka Island has been investigated using mtDNA HVS-I sequence data. This is the first genetic study to characterize Failaka Island population. The result showed that the Kuwaiti population has a high frequency of Y- haplogroup J1 (37%) similar to other Arabian populations. -
Eurasian and Sub-Saharan African Mitochondrial DNA Haplogroup Influences Pseudoexfoliation Glaucoma Development in Saudi Patients
Molecular Vision 2011; 17:543-547 <http://www.molvis.org/molvis/v17/a62> © 2011 Molecular Vision Received 24 January 2011 | Accepted 14 February 2011 | Published 19 February 2011 Eurasian and Sub-Saharan African mitochondrial DNA haplogroup influences pseudoexfoliation glaucoma development in Saudi patients Khaled K. Abu-Amero,1 Vicente M. Cabrera,2 José M. Larruga,2 Essam A. Osman,1 Ana M. González,2 Saleh A. Al-Obeidan1 1Ophthalmic Genetics Laboratory, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Área de Genética. Departamento de Parasitología, Ecología y Genética. Facultad de Biología, Universidad de La Laguna (ULL). Avenida Astrofísico Francisco Sánchez, s/n. 38206 La Laguna (Tenerife), Spain Purpose: To investigate whether different mitochondrial DNA (mtDNA) haplogroups have a role on the development of pseudoexfoliation glaucoma (PEG) in the Saudi Arab population. Methods: The mtDNA regulatory region and coding regions comprising mtDNA haplogroup diagnostic polymorphisms were sequenced in patients with PEG (n=94), healthy matched controls (free of PEG; n=112) and a healthy Saudi Arab population group (n=810). Results: The Eurasian haplogroup T and the Sub-Saharan African Haplogroup L2 confer susceptibility to PEG, whereas the Eurasian haplogroup N1 was associated with reduced risk to develop PEG in the Saudi Arab population. Conclusions: Mitochondrial haplogroups T and L2 may play a role in the development of PEG in the Saudi Arabian population. Pseudoexfoliation (PEX) syndrome is a generalized variants in the Lysyl oxidase-like 1 (LOXL1) autosomal gene. disorder of the extracellular matrix and currently represents This association was first detected in Nordic European the most commonly identified specific cause of open-angle samples [7] and, since then, confirmed in samples with broad glaucoma [1]. -
Reconstructing Druze Population History Scarlett Marshall1, Ranajit Das2, Mehdi Pirooznia3 & Eran Elhaik4
www.nature.com/scientificreports OPEN Reconstructing Druze population history Scarlett Marshall1, Ranajit Das2, Mehdi Pirooznia3 & Eran Elhaik4 The Druze are an aggregate of communities in the Levant and Near East living almost exclusively in Received: 27 April 2016 the mountains of Syria, Lebanon and Israel whose ~1000 year old religion formally opposes mixed Accepted: 05 October 2016 marriages and conversions. Despite increasing interest in genetics of the population structure of the Published: 16 November 2016 Druze, their population history remains unknown. We investigated the genetic relationships between Israeli Druze and both modern and ancient populations. We evaluated our findings in light of three hypotheses purporting to explain Druze history that posit Arabian, Persian or mixed Near Eastern- Levantine roots. The biogeographical analysis localised proto-Druze to the mountainous regions of southeastern Turkey, northern Iraq and southeast Syria and their descendants clustered along a trajectory between these two regions. The mixed Near Eastern–Middle Eastern localisation of the Druze, shown using both modern and ancient DNA data, is distinct from that of neighbouring Syrians, Palestinians and most of the Lebanese, who exhibit a high affinity to the Levant. Druze biogeographic affinity, migration patterns, time of emergence and genetic similarity to Near Eastern populations are highly suggestive of Armenian-Turkish ancestries for the proto-Druze. The population history of the Druze people, who accepted Druzism around the 11th century A.D., remains a fascinating question in history, cultural anthropology and genetics. Contemporary Druze comprise an aggre- gate of Levantine and Near Eastern communities residing almost exclusively in the mountain regions of Syria (500,000), Lebanon (215,000), Israel (136,000) and Jordan (20,000), although with an increasingly large diaspora in the USA1–3. -
Rare Human Mitochondrial HV Lineages Spread from the Near East
www.nature.com/scientificreports OPEN Rare human mitochondrial HV lineages spread from the Near East and Caucasus during post-LGM and Received: 11 January 2019 Accepted: 21 June 2019 Neolithic expansions Published: xx xx xxxx Michel Shamoon-Pour1, Mian Li2 & D. Andrew Merriwether1 Of particular signifcance to human population history in Eurasia are the migratory events that connected the Near East to Europe after the Last Glacial Maximum (LGM). Utilizing 315 HV*(xH,V) mitogenomes, including 27 contemporary lineages frst reported here, we found the genetic signatures for distinctive movements out of the Near East and South Caucasus both westward into Europe and eastward into South Asia. The parallel phylogeographies of rare, yet widely distributed HV*(xH,V) subclades reveal a connection between the Italian Peninsula and South Caucasus, resulting from at least two (post-LGM, Neolithic) waves of migration. Many of these subclades originated in a population ancestral to contemporary Armenians and Assyrians. One such subclade, HV1b-152, supports a postexilic, northern Mesopotamian origin for the Ashkenazi HV1b2 lineages. In agreement with ancient DNA fndings, our phylogenetic analysis of HV12 and HV14, the two exclusively Asian subclades of HV*(xH,V), point to the migration of lineages originating in Iran to South Asia before and during the Neolithic period. With HV12 being one of the oldest HV subclades, our results support an origin of HV haplogroup in the region defned by Western Iran, Mesopotamia, and the South Caucasus, where the highest prevalence of HV has been found. Te major subclade of R0, haplogroup HV has a pivotal position in human mitochondrial (mtDNA) phylogeny as the ancestral clade to haplogroup H-the most common clade in Europe1 and the best-defned mtDNA hap- logroup according to Phylotree2. -
Western Eurasian Ancestry in Modern Siberians Based on Mitogenomic Data
Derenko et al. BMC Evolutionary Biology 2014, 14:217 http://www.biomedcentral.com/1471-2148/14/217 RESEARCH ARTICLE Open Access Western Eurasian ancestry in modern Siberians based on mitogenomic data Miroslava Derenko1*, Boris Malyarchuk1, Galina Denisova1, Maria Perkova1, Andrey Litvinov1, Tomasz Grzybowski2, Irina Dambueva3, Katarzyna Skonieczna2, Urszula Rogalla2, Iosif Tsybovsky4 and Ilya Zakharov5 Abstract Background: Although the genetic heritage of aboriginal Siberians is mostly of eastern Asian ancestry, a substantial western Eurasian component is observed in the majority of northern Asian populations. Traces of at least two migrations into southern Siberia, one from eastern Europe and the other from western Asia/the Caucasus have been detected previously in mitochondrial gene pools of modern Siberians. Results: We report here 166 new complete mitochondrial DNA (mtDNA) sequences that allow us to expand and re-analyze the available data sets of western Eurasian lineages found in northern Asian populations, define the phylogenetic status of Siberian-specific subclades and search for links between mtDNA haplotypes/subclades and events of human migrations. From a survey of 158 western Eurasian mtDNA genomes found in Siberia we estimate that nearly 40% of them most likely have western Asian and another 29% European ancestry. It is striking that 65 of northern Asian mitogenomes, i.e. ~41%, fall into 19 branches and subclades which can be considered as Siberian-specific being found so far only in Siberian populations. From the coalescence analysis it is evident that the sequence divergence of Siberian-specific subclades was relatively small, corresponding to only 0.6-9.5 kya (using the complete mtDNA rate) and 1–6kya(codingregionrate).