DOCSLIB.ORG

Table of Contents (PDF)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Table of Contents (PDF) December 20, 2016 u vol. 113 u no. 51 From the Cover 14502 Human–environment interactions 14704 N2O production during nitrification 14769 Tooth evolution in sharks 14811 Therapeutic bacteria in New York City parks Contents Cover image: Pictured are dog owners THIS WEEK IN PNAS queueing with their pets to receive 14463 In This Issue canine rabies vaccination during a campaign in northwest Tanzania. Alison Galvani et al. introduce the INNER WORKINGS—An over-the-shoulder look at scientists at work Sackler Colloquium on Coupled Human and Environmental Systems, which 14465 Orbiting experiment may help decode the mysteries of rubbly asteroids explores the interconnectedness of Sid Perkins environmental, epidemiological, political, and economic systems as well PROFILE as potential solutions to challenges in public health and resource sustainability. 14468 Profile of Harris A. Lewin Topics range from the cost-effectiveness Beth Azar of canine rabies vaccination programs to See Inaugural Article on page 14492 recent successes in employing a complex adaptive-systems framework COMMENTARIES to promote sustainable fisheries. See the Introduction to the Sackler Colloquium 14471 Love, not war, drove the Mesozoic marine revolution on Coupled Human and Environmental Phillip M. Novack-Gottshall Systems on pages 14502–14506. Image See companion article on page 14073 in issue 49 of volume 113 courtesy of Meagan C. Fitzpatrick (Yale 14474 Is there a pathway for N2O production from hydroxylamine oxidoreductase in University, New Haven, CT). ammonia-oxidizing bacteria? Corey J. White and Nicolai Lehnert See companion article on page 14704 14477 Antibiotic discovery is a walk in the park Louis-Fe´lix Nothias, Rob Knight, and Pieter C. Dorrestein See companion article on page 14811 PNAS PLUS 14480 Significance Statements Brief statements written by the authors about the significance of their papers. PERSPECTIVE 14483 Twenty-first century approaches to ancient problems: Climate and society Jade A. d’Alpoim Guedes, Stefani A. Crabtree, R. Kyle Bocinsky, and Timothy A. Kohler Free online through the PNAS open access option. PNAS u December 20, 2016 u vol. 113 u no. 51 u iii–viii Downloaded by guest on September 25, 2021 INAUGURAL ARTICLE 14595 Estimating enhanced prevaccination measles transmission hotspots in the context of 14492 Massive dysregulation of genes involved in cell signaling cross-scale dynamics and placental development in cloned cattle Alexander D. Becker, Ruthie B. Birger, Aude Teillant, Paul A. conceptus and maternal endometrium Gastanaduy, Gregory S. Wallace, and Bryan T. Grenfell Fernando H. Biase, Chanaka Rabel, Michel Guillomot, Isabelle 14601 Climatic and evolutionary drivers of phase shifts in the Hue, Kalista Andropolis, Colleen A. Olmstead, Rosane Oliveira, plague epidemics of colonial India Richard Wallace, Daniel Le Bourhis, Christophe Richard, Evelyne Campion, Aure´lie Chaulot-Talmon, Corinne Giraud-Delville, Joseph A. Lewnard and Jeffrey P. Townsend Ge´raldine Taghouti, He´le`ne Jammes, Jean-Paul Renard, Olivier Sandra, and Harris A. Lewin PHYSICAL SCIENCES See Profile on page 14468 APPLIED MATHEMATICS ARTHUR M. SACKLER COLLOQUIUM ON COUPLED 14609 State estimation and prediction using clustered HUMAN AND ENVIRONMENTAL SYSTEMS particle filters Yoonsang Lee and Andrew J. Majda INTRODUCTION 14502 Human–environment interactions in population and APPLIED PHYSICAL SCIENCES ecosystem health 14615 Emergent oscillations assist obstacle negotiation Alison P. Galvani, Chris T. Bauch, Madhur Anand, Burton H. during ant cooperative transport Singer, and Simon A. Levin Aviram Gelblum, Itai Pinkoviezky, Ehud Fonio, Nir S. Gov, and Ofer Feinerman COLLOQUIUM PAPERS 14621 Emergent structures and dynamics of cell colonies by 14507 The right incentives enable ocean sustainability contact inhibition of locomotion successes and provide hope for the future Bart Smeets, Ricard Alert, Jirı´ Pesek, Ignacio Pagonabarraga, Jane Lubchenco, Elizabeth B. Cerny-Chipman, Jessica N. Herman Ramon, and Romaric Vincent Reimer, and Simon A. Levin 14627 Unfolding large-scale online collaborative 14515 Coordination vs. voluntarism and enforcement in human dynamics sustaining international environmental cooperation Yilong Zha, Tao Zhou, and Changsong Zhou Scott Barrett 14523 Whales, science, and scientific whaling in the CHEMISTRY International Court of Justice 14633 Specific detection of biomolecules in physiological Marc Mangel solutions using graphene transistor biosensors Ning Gao, Teng Gao, Xiao Yang, Xiaochuan Dai, Wei Zhou, 14528 Examples of coupled human and environmental Anqi Zhang, and Charles M. Lieber systems from the extractive industry and hydropower sector interfaces 14686 Evolution of a mass spectrometry-grade protease with Marcia C. Castro, Gary R. Krieger, Marci Z. Balge, Marcel Tanner, PTM-directed specificity Ju¨rg Utzinger, Maxine Whittaker, and Burton H. Singer Duc T. Tran, Valerie J. Cavett, Vuong Q. Dang, He´ctor L. Torres, and Brian M. Paegel 14536 Interactions of social, terrestrial, and marine sub-systems in the Galapagos Islands, Ecuador 14739 Janus effect of antifreeze proteins on ice nucleation Stephen J. Walsh and Carlos F. Mena Kai Liu, Chunlei Wang, Ji Ma, Guosheng Shi, Xi Yao, Haiping Fang, Yanlin Song, and Jianjun Wang 14544 Quantifying and sustaining biodiversity in tropical agricultural landscapes EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Chase D. Mendenhall, Analisa Shields-Estrada, Arjun J. Krishnaswami, and Gretchen C. Daily 14757 Anomalously high variation in postnatal development is ancestral for dinosaurs but lost in birds 14552 Alternative stable states and the sustainability of Christopher T. Griffin and Sterling J. Nesbitt forests, grasslands, and agriculture Kirsten A. Henderson, Chris T. Bauch, and Madhur Anand ENGINEERING 14560 Early warning signals of regime shifts in coupled – E8210 Concentrator photovoltaic module architectures with human environment systems capabilities for capture and conversion of full global Chris T. Bauch, Ram Sigdel, Joe Pharaon, and Madhur Anand solar radiation 14568 Timescales and the management of ecological systems Kyu-Tae Lee, Yuan Yao, Junwen He, Brent Fisher, Xing Sheng, Alan Hastings Matthew Lumb, Lu Xu, Mikayla A. Anderson, David Scheiman, 14574 One Health approach to cost-effective rabies control Seungyong Han, Yongseon Kang, Abdurrahman Gumus, Rabab R. Bahabry, Jung Woo Lee, Ungyu Paik, Noah D. Bronstein, A. Paul in India Alivisatos, Matthew Meitl, Scott Burroughs, Muhammad Mustafa Meagan C. Fitzpatrick, Hiral A. Shah, Abhishek Pandey, Hussain, Jeong Chul Lee, Ralph G. Nuzzo, and John A. Rogers Alyssa M. Bilinski, Manish Kakkar, Andrew D. Clark, Jeffrey P. Townsend, Syed Shahid Abbas, and Alison P. Galvani ENVIRONMENTAL SCIENCES 14582 Perspectives on the role of mobility, behavior, and E8219 Measuring spectroscopy and magnetism of extracted time scales in the spread of diseases and intracellular magnetosomes using soft Carlos Castillo-Chavez, Derdei Bichara, and Benjamin R. Morin X-ray ptychography 14589 Impact of El Niño Southern Oscillation on infectious Xiaohui Zhu, Adam P. Hitchcock, Dennis A. Bazylinski, Peter disease hospitalization risk in the United States Denes, John Joseph, Ulysses Lins, Stefano Marchesini, David N. Fisman, Ashleigh R. Tuite, and Kevin A. Brown Hung-Wei Shiu, Tolek Tyliszczak, and David A. Shapiro iv u www.pnas.org Contents Downloaded by guest on September 25, 2021 14639 Understanding the nature of atmospheric acid 14528 Examples of coupled human and environmental processing of mineral dusts in supplying systems from the extractive industry and bioavailable phosphorus to the oceans hydropower sector interfaces Anthony Stockdale, Michael D. Krom, Robert J. G. Mortimer, Liane Marcia C. Castro, Gary R. Krieger, Marci Z. Balge, Marcel Tanner, G. Benning, Kenneth S. Carslaw, Ross J. Herbert, Zongbo Shi, Ju¨rg Utzinger, Maxine Whittaker, and Burton H. Singer Stelios Myriokefalitakis, Maria Kanakidou, and Athanasios Nenes 14536 Interactions of social, terrestrial, and marine sub-systems in the Galapagos Islands, Ecuador PHYSICS Stephen J. Walsh and Carlos F. Mena 14645 Ideal charge-density-wave order in the high-field state of superconducting YBCO H. Jang, W.-S. Lee, H. Nojiri, S. Matsuzawa, H. Yasumura, L. Nie, SOCIAL SCIENCES A. V. Maharaj, S. Gerber, Y.-J. Liu, A. Mehta, D. A. Bonn, R. Liang, 14668 Estimating uncertainty in respondent-driven sampling W. N. Hardy, C. A. Burns, Z. Islam, S. Song, J. Hastings, T. P. Devereaux, using a tree bootstrap method Z.-X. Shen, S. A. Kivelson, C.-C. Kao, D. Zhu, and J.-S. Lee Aaron J. Baraff, Tyler H. McCormick, and Adrian E. Raftery 14651 Imaging the He2 quantum halo state using a free electron laser SUSTAINABILITY SCIENCE Stefan Zeller, Maksim Kunitski, Jo¨rg Voigtsberger, Anton Kalinin, Alexander Schottelius, Carl Schober, Markus Waitz, 14507 The right incentives enable ocean sustainability Hendrik Sann, Alexander Hartung, Tobias Bauer, Martin Pitzer, successes and provide hope for the future Florian Trinter, Christoph Goihl, Christian Janke, Martin Richter, Jane Lubchenco, Elizabeth B. Cerny-Chipman, Jessica N. Gregor Kastirke, Miriam Weller, Achim Czasch, Markus Kitzler, Reimer, and Simon A. Levin Markus Braune, Robert E. Grisenti, Wieland Scho¨llkopf, Lothar 14515 Coordination vs. voluntarism and enforcement in Ph. H. Schmidt, Markus S. Scho¨ffler, Joshua B. Williams, Till Jahnke, and Reinhard Do¨rner sustaining international environmental cooperation Scott Barrett 14656 Direct evidence of interaction-induced
Load more

Recommended publications
  • The Dopamine Transporter: More Exciting Than Housekeeping
    The Dopamine Transporter: More Exciting than Housekeeping Susan Ingram Washington State University Vancouver Dopaminergic Synapse Presynaptic cell MGluR 2 Na+ Cl- GIRK D2 DA DA D2 D1 a1 Postsynaptic cell Currents are activated at lower dopamine concentrations than are required for transport Ingram, et al., 2002 Low DA concentrations increase firing Ingram, et al., 2002 DAT-mediated chloride current is excitatory in cultured midbrain DA neurons DEPOLARIZATION HYPERPOLARIZATION Ingram, et al., 2002 Proteins that regulate intracellular Cl- Whole-cell patch clamp recordings from DA neurons Raclopride Sulpiride Prazosin TTX biocytin Prasad and Amara, 2001 Amphetamine activates a DAT-mediated current at low concentrations Cultures Slices Watts, Fyfe and Ingram, unpublished data. DA neurons make glutamatergic autapses in culture and amphetamine increases AMPA currents Ingram, et al., unpublished data mbYFPQS localizes to the membrane of cultured midbrain neurons Watts, Jimenez and Ingram, unpublished data. Amphetamine stimulates a dose-dependent change in mbYFPQS fluorescence in both soma and dendrites of DA neurons Watts and Ingram, unpublished data. KCC2 Expression is different in cultures and slices cultures slices TH KCC2 Jamieson and Ingram, unpublished data. Baculoviral Transfections Watts and Ingram, unpublished data. Summary • DAT-mediated chloride current may alter excitability of DA neurons and integration of synaptic activity. • The current may be activated selectively (relative to transport) by low DA and amphetamine concentrations suggesting a role in increasing release of DA. • The amphetamine-mediated current is dose-dependent in both cultures and slices of midbrain neurons but is inhibited at high amphetamine concentrations (20 µM). • The mbYFPQS is a sensitive tool to measure intracellular chloride concentrations (K50 = 30 mM) and is useful for monitoring changes in intracellular chloride concentrations in dendrites.
    [Show full text]
  • Program Book
    PARKINSON’SDISEASE2014 ADVANCING RESEARCH, IMPROVING LIVES PROGRAM MATERIALS Sponsored by: January 6 – 7, 2014 Natcher Conference Center National Institutes of Health Bethesda, MD About our cover: The program cover image is a stylized version of the Parkinson’s Disease Motor-Related Pattern (PDRP), an abnormal pattern of regional brain function observed in MRI studies which shows increased metabolism indicated by red in some brain regions (pallidothalamic, pontine, and motor cortical areas), and decreased metabolism indicated by blue in others (associated lateral premotor and posterior parietal areas). Original image used with permission of David Eidelberg, M.D. For further information see: Hirano et al., Journal of Neuroscience 28 (16): 4201-4209. Welcome Message from Dr. Story C. Landis Welcome to the National Institute of Neurological Disorders and Stroke (NINDS) conference, “Parkinson’s Disease 2014: Advancing Research, Improving Lives.” Remarkable new discoveries and technological advances are rapidly changing the way we study the biological mechanisms of Parkinson’s disease, identify paths to improved treatments, and design effective clinical trials. Elucidating mechanisms and developing and testing effective interventions require a diverse set of approaches and perspectives. The NINDS has organized this conference with the primary goal of seeking consensus on, and prioritizing, research recommendations spanning clinical, translational, and basic Parkinson’s disease research that we support. We have assembled a stellar and dedicated group of session chairs and panelists who have worked collaboratively to identify emerging research opportunities in Parkinson’s research. While we have divided our working groups into three main research areas, we expect each will inform the others over the course of the next two days, and we look forward to both complementary and unique perspectives.
    [Show full text]
  • Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Cav2.1 and Cav2.2 in Rat Midbrain Neurons
    This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Article: New Research | Neuronal Excitability Isoflurane inhibits dopaminergic synaptic vesicle exocytosis coupled to CaV2.1 and CaV2.2 in rat midbrain neurons Christina L. Torturo1,2, Zhen-Yu Zhou1, Timothy A. Ryan1,3 and Hugh C. Hemmings1,2 1Departments of Anesthesiology, Weill Cornell Medicine, New York, NY 10065 2Pharmacology, Weill Cornell Medicine, New York, NY 10065 3Biochemistry, Weill Cornell Medicine, New York, NY 10065 https://doi.org/10.1523/ENEURO.0278-18.2018 Received: 16 July 2018 Revised: 18 December 2018 Accepted: 21 December 2018 Published: 10 January 2019 Author Contributions: CLT, ZZ, TAR and HCH designed the research; CLT performed the research, TAR contributed unpublished reagents/analytic tools; CLT and ZZ analyzed the data; CLT, ZZ, TAR, and HCH wrote the paper. Funding: http://doi.org/10.13039/100000002HHS | National Institutes of Health (NIH) GM58055 Conflict of Interest: HCH: Editor-in-Chief of the British Journal of Anaesthesia; consultant for Elsevier. Funding Sources: NIH GM58055 Corresponding author: Hugh C. Hemmings, E-mail: [email protected] Cite as: eNeuro 2019; 10.1523/ENEURO.0278-18.2018 Alerts: Sign up at www.eneuro.org/alerts to receive customized email alerts when the fully formatted version of this article is published. Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. Copyright © 2019 Torturo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
    [Show full text]
  • Conference Schedule
    Society on NeuroImmune Pharmacology (SNIP) 23rd Scientific Conference Hotel DOUBLETREE BY HILTON PHILADELPHIA CENTER CITY Philadelphia, PA, USA March 29 - April 1, 2017 Previous Conferences:1993 Toronto Hilton, Canada; 1994 Breakers, Palm Beach, FL; 1995 Bristol Court, San Diego, CA; 1996 Caribe Hilton, San Juan, PR; 1997 Opryland Hotel, Nashville TN; 1998 Scottsdale Princess, Scottsdale, AR; 2000 NIH Mazur Auditorium, Bethesda MD; 2001 Emory University, Atlanta, GA; 2002 Clearwater Beach Hilton, Clear Water, FL; 2004, La Fonda Hotel, Santa Fe, NM; 2005 Clearwater Beach Hilton, Clear Water, FL; 2006 La Fonda Hotel, Santa Fe, NM; 2007 City Center Marriott Hotel, Salt Lake City, UT; 2008 Francis Marion Hotel, Charleston, SC; 2009 Pearl Plaza Howard Johnson, Wuhan, China; 2010 Manhattan Beach Marriott, Manhattan Beach, CA; 2011 Hilton Clearwater Beach Resort, Clear Water Beach, FL; 2012 Hawaii Prince Hotel, Honolulu, HI; 2013 Conrad Hilton, San Juan, PR; 2014 Intercontinental New Orleans, LA.; 2015; Hyatt Regency, Miami, FL; 2016, Hotel Galaxy, Krakow, Poland. Page 1 TABLE OF CONTENTS Title Page 1 Table of Contents 2 Acknowledgement of Special Contributors and Sponsors 3-5 The SNIP Council, Officials, and Committees 6-7 Annual Society Awards 8-9 2016 Early Career Investigator Travel Awardees 9-11 2016 Plenary Speaker Biographies 12-14 Conference Agenda Wednesday March 29, 2017 City-Wide NeuroAIDS Discussion Group 15-16 Opening Reception 16 Poster Session 1 (W1-72, Abstract listings page 25) 16 1st Annual DISC Networking Hour 16 Thursday March 30, 2017 Presidential Symposium: Dopamine Neurotransmission in HIV-1 Infection 16-17 Presidential Symposium: Dr. David Sulzer 17 Symposium 2: Novel mechanisms of CNS infection 17-18 Meet the Mentors Lunch 18 SNIP Council Meeting 18 Pharmacology Symposium: Dr.
    [Show full text]
  • Fall 2014 Columbia Magazine Collaborations 45 Startups
    FALL 2014 COLUMBIA MAGAZINE COLLABORATIONS 45 STARTUPS. 1 GARAGE. C1_FrontCover_v1.indd C1 10/1/14 4:41 PM ChangeCHANGETHEWORLD lives, On October 29, join Columbians around the globe for 24 hours of giving back, connecting, and chances to win matching funds for your favorite school or program. Changing Lives That Change The World givingday.columbia.edu #ColumbiaGivingDay C2_GivingDay.indd C2 9/30/14 5:45 PM CONTENTS Fall 2014 12 44 26 DEPARTMENTS FEATURES 3 Letters 12 Start Me Up By Rebecca Shapiro 6 Primary Sources The new Columbia Startup Lab in SoHo is open Darwin in plain English . Gail Sheehy’s New York for business. We visit some young entrepreneurs to memories . Eric Holder goes to Ferguson see what clicks. 8 College Walk 22 Streams and Echoes Grab your coat and get your stethoscope . By Tim Page Decanterbury tales . Kenneth Waltz: The composer Chou Wen-chung, featured this fall as one A remembrance of the Miller Theatre’s “Composer Portraits,” has been connecting East and West for more than sixty years. 48 News Amale Andraos named dean of GSAPP . 26 The Professor’s Last Stand Columbia gives seed grants to overseas research By David J. Craig projects . Brown Institute for Media Innovation US historian Eric Foner is trying something new before opens its doors . Columbia Secondary School he retires: he’s fi lming a massive open online course, graduates its fi rst class . David Goldstein or MOOC. Call it a Lincoln login. recruited to head new genomics institute . Bollinger’s term extended 34 Rewired By Paul Hond 53 Newsmakers Law professor Tim Wu, the coiner of “net neutrality,” entered New York’s lieutenant-governor race to change 55 Explorations politics.
    [Show full text]
  • Development of a Lab-On-A-Chip Device for Rapid Nanotoxicity Assessment in Vitro Pratikkumar Shah Engineering, [email protected]
    Florida International University FIU Digital Commons FIU Electronic Theses and Dissertations University Graduate School 12-11-2014 Development of a Lab-on-a-Chip Device for Rapid Nanotoxicity Assessment In Vitro Pratikkumar Shah Engineering, [email protected] DOI: 10.25148/etd.FI15032160 Follow this and additional works at: https://digitalcommons.fiu.edu/etd Part of the Analytical Chemistry Commons, Bioelectrical and Neuroengineering Commons, Biomedical Devices and Instrumentation Commons, Electronic Devices and Semiconductor Manufacturing Commons, Molecular, Cellular, and Tissue Engineering Commons, and the Nanotechnology Fabrication Commons Recommended Citation Shah, Pratikkumar, "Development of a Lab-on-a-Chip Device for Rapid Nanotoxicity Assessment In Vitro" (2014). FIU Electronic Theses and Dissertations. 1834. https://digitalcommons.fiu.edu/etd/1834 This work is brought to you for free and open access by the University Graduate School at FIU Digital Commons. It has been accepted for inclusion in FIU Electronic Theses and Dissertations by an authorized administrator of FIU Digital Commons. For more information, please contact [email protected]. FLORIDA INTERNATIONAL UNIVERSITY Miami, Florida DEVELOPMENT OF A LAB-ON-A-CHIP DEVICE FOR RAPID NANOTOXICITY ASSESSMENT IN VITRO A dissertation submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in BIOMEDICAL ENGINEERING by Pratikkumar Shah 2015 To: Dean Amir Mirmiran College of Engineering and Computing This dissertation, written by Pratikkumar Shah, and entitled Development of a Lab-on-a- Chip Device for Rapid Nanotoxicity Assessment In Vitro, having been approved in respect to style and intellectual content, is referred to you for judgment. We have read this dissertation and recommend that it be approved.
    [Show full text]
  • Methamphetamine-Induced Degeneration of Dopaminergic Neurons Involves Autophagy and Upregulation of Dopamine Synthesis
    The Journal of Neuroscience, October 15, 2002, 22(20):8951–8960 Methamphetamine-Induced Degeneration of Dopaminergic Neurons Involves Autophagy and Upregulation of Dopamine Synthesis Kristin E. Larsen,1 Edward A. Fon,2 Teresa G. Hastings,3 Robert H. Edwards,4 and David Sulzer1 1Departments of Neurology and Psychiatry, Columbia University, and Department of Neuroscience, New York Psychiatric Institute, New York, New York 10032, 2Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada, 3Departments of Neuroscience and Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, and 4Departments of Neurology and Physiology, University of California, San Francisco, California 94143 Methamphetamine (METH) selectively injures the neurites of pression. METH administration also promoted the synthesis of dopamine (DA) neurons, generally without inducing cell death. It DA via upregulation of tyrosine hydroxylase activity, resulting in has been proposed that METH-induced redistribution of DA an elevation of cytosolic DA even in the absence of vesicular from the vesicular storage pool to the cytoplasm, where DA can sequestration. Electron microscopy and fluorescent labeling oxidize to produce quinones and additional reactive oxygen confirmed that METH promoted the formation of autophagic species, may account for this selective neurotoxicity. To test granules, particularly in neuronal varicosities and, ultimately, this hypothesis, we used mice heterozygous (ϩ/Ϫ) or homozy- within cell bodies of dopaminergic neurons. Therefore, we pro- gous (Ϫ/Ϫ) for the brain vesicular monoamine uptake trans- pose that METH neurotoxicity results from the induction of a porter VMAT2, which mediates the accumulation of cytosolic specific cellular pathway that is activated when DA cannot be DA into synaptic vesicles.
    [Show full text]
  • Mens Rea and Methamphetamine: High Time for a Modern Doctrine Acknowledging the Neuroscience of Addiction
    Fordham Law Review Volume 85 Issue 5 Article 20 2017 Mens Rea and Methamphetamine: High Time for a Modern Doctrine Acknowledging the Neuroscience of Addiction Meredith Cusick Fordham University School of Law Follow this and additional works at: https://ir.lawnet.fordham.edu/flr Part of the Criminal Law Commons Recommended Citation Meredith Cusick, Mens Rea and Methamphetamine: High Time for a Modern Doctrine Acknowledging the Neuroscience of Addiction, 85 Fordham L. Rev. 2417 (2017). Available at: https://ir.lawnet.fordham.edu/flr/vol85/iss5/20 This Note is brought to you for free and open access by FLASH: The Fordham Law Archive of Scholarship and History. It has been accepted for inclusion in Fordham Law Review by an authorized editor of FLASH: The Fordham Law Archive of Scholarship and History. For more information, please contact [email protected]. MENS REA AND METHAMPHETAMINE: HIGH TIME FOR A MODERN DOCTRINE ACKNOWLEDGING THE NEUROSCIENCE OF ADDICTION Meredith Cusick* In American criminal law, actus non facit reum, nisi mens sit rea, “an act does not make one guilty, without a guilty mind.” Both actus reus and mens rea are required to justify criminal liability. The Model Penal Code’s (MPC) section on culpability has been especially influential on mens rea analysis. An issue of increasing importance in this realm arises when an offensive act is committed while the actor is under the influence of drugs. Several legal doctrines address the effect of intoxication on mental state, including the MPC, limiting or eliminating its relevance to the mens rea analysis. Yet these doctrines do not differentiate between intoxication and addiction.
    [Show full text]
  • Arxiv:2107.12536V2 [Q-Bio.NC] 1 Sep 2021
    ADATA-DRIVEN BIOPHYSICAL COMPUTATIONAL MODEL OF PARKINSON’S DISEASE BASED ON MARMOSET MONKEYS Caetano M. Ranieri Jhielson M. Pimentel Institute of Mathematical and Computer Sciences Edinburgh Centre for Robotics University of Sao Paulo Heriot-Watt University Sao Carlos, SP, Brazil Edinburgh, Scotland, UK [email protected] [email protected] Marcelo R. Romano Leonardo A. Elias School of Electrical and Computer Engineering School of Electrical and Computer Engineering University of Campinas University of Campinas Campinas, SP, Brazil Campinas, SP, Brazil [email protected] [email protected] Roseli A. F. Romero Michael A. Lones Institute of Mathematical and Computer Sciences Edinburgh Centre for Robotics University of Sao Paulo Heriot-Watt University Sao Carlos, SP, Brazil Edinburgh, Scotland, UK [email protected] [email protected] Mariana F. P. Araujo Patricia A. Vargas Health Sciences Centre Edinburgh Centre for Robotics Federal University of Espirito Santo Heriot-Watt University Vitoria, ES, Brazil Edinburgh, Scotland, UK [email protected] [email protected] Renan C. Moioli Digital Metropolis Institute Federal University of Rio Grande do Norte Natal, RN, Brazil [email protected] September 2, 2021 arXiv:2107.12536v2 [q-bio.NC] 1 Sep 2021 ABSTRACT In this work we propose a new biophysical computational model of brain regions relevant to Parkin- son’s Disease (PD) based on local field potential data collected from the brain of marmoset monkeys. Parkinson’s disease is a neurodegenerative disorder, linked to the death of dopaminergic neurons at the substantia nigra pars compacta, which affects the normal dynamics of the basal ganglia-thalamus- cortex (BG-T-C) neuronal circuit of the brain.
    [Show full text]
  • Fonction Et Dysfonction Dans La Maladie De Parkinson
    THESE DE DOCTORAT DE L’UNIVERSITE PIERRE ET MARIE CURIE École doctorale n°158 Cerveau, Cognition, et Comportement Présentée et soutenue par Evinaa SELLAIAH pour obtenir le titre de DOCTEUR DE L’UNIVERSITE PIERRE ET MARIE CURIE Spécialité : Neurosciences Le noyau subthalamique et le contrôle moteur : Fonction et dysfonction dans la maladie de Parkinson soutenue le 24 novembre 2017 Jury : Président : M. Bernard PIDOUX - Université Pierre et Marie Curie, Paris, France Rapporteur : Mme. Patricia LIMOUSIN - University College London, Londres, Royaume-Uni Rapporteur : M. Paul SAULEAU - Institut des Neurosciences Cliniques de Rennes, France Examinateur : M. Stéphane DERREY - Département de Neurochirurgie, CHU de Rouen, France Examinateur : M. Laurent VENANCE - Collège de France, Paris, France Directrice de thèse : Mme Carine KARACHI - Institut du Cerveau et de la Moelle Épinière, Paris, France Remerciements *** Je ne pourrai commencer cette thèse sans une page dédiée aux remerciements, ce sera certainement la page la plus lue de tout mon manuscrit! Je remercie tout particulièrement Monsieur Dufloux, de m’avoir permis de réaliser ce travail de recherche. Merci à Carine Karachi pour m’avoir encadrée, conseillée, soutenue, supportée tout au long de ce travail, et pour tes multiples relectures de ce manuscrit. Merci à Brian Lau pour m’avoir accueillie dans l’équipe, encadrée, et aidée pour les analyses électrophysiologiques et statistiques. Je remercie chaleureusement les membres du jury pour l’honneur qu’ils me font de consacrer une partie de leur temps pour juger ce travail. Je remercie Nathalie Georges pour les multiples relectures de ce manuscrit et l’aide ap- portée dans les analyses. Un grand merci à Marie-Laure Welter, qui m’a fait découvrir la recherche clinique et la maladie de Parkinson d’un point de vue clinique.
    [Show full text]
  • Roles for -Synuclein in Gene Expression
    G C A T T A C G G C A T genes Review Roles for α-Synuclein in Gene Expression Mahalakshmi Somayaji 1, Zina Lanseur 1, Se Joon Choi 1, David Sulzer 1,2 and Eugene V. Mosharov 1,2,* 1 Departments of Psychiatry and Neurology, Columbia University Medical Center, New York, NY 10032, USA; [email protected] (M.S.); [email protected] (Z.L.); [email protected] (S.J.C.); [email protected] (D.S.) 2 Division of Molecular Therapeutics, New York State Psychiatric Institute, Research Foundation for Mental Hygiene, New York, NY 10032, USA * Correspondence: [email protected] Abstract: α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular com- partments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson’s disease (PD) via a gain-of- function mechanism. Because of this, several recent strategies propose to decrease α-Syn levels in PD patients. While these therapies may offer breakthroughs in PD management, the normal functions of α-Syn and potential side effects of its depletion require careful evaluation. Here, we review recent evidence on physiological and pathological roles of α-Syn in regulating activity-dependent signal transduction and gene expression pathways that play fundamental role in synaptic plasticity. Keywords: Parkinson’s disease; α-Synuclein; gene expression; signal transduction; epigenetics; silencing therapeutics; nuclear receptors; calcium channels Citation: Somayaji, M.; Lanseur, Z.; Choi, S.J.; Sulzer, D.; Mosharov, E.V.
    [Show full text]
  • Elemental and Neurochemical Based Analysis of the Pathophysiological Mechanisms of Gilles De La Tourette Syndrome
    MEDIZINISCHE HOCHSCHULE HANNOVER Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie Elemental and Neurochemical Based Analysis of the Pathophysiological Mechanisms of Gilles de la Tourette syndrome INAUGURALDISSERTATION zur Erlangung des Grades einer Doktorin oder eines Doktors der Naturwissenschaften Doctor rerum naturalium - Dr. rer. nat. vorgelegt von Ahmad Seif Kanaan B.Sc., M.Sc geb. am 17/05/1986, Amman, Jordanien Hannover, Deutschland (2017) Promotionsordnung der Medizinischen Hochschule Hannover für die Erlangung des Grades einer Doktorin/eines Doktors der Naturwissenschaften (Doctor rerum naturalium) Letzte Änderung in der 523. Sitzung Senatssitzung vom 15.07.2015 Wissenschaftliche Betreuung: Prof. Dr. med. Kirsten Müller-Vahl Wissenschaftliche Zweitbetreuung: Prof. Dr. rer. nat. Claudia Grothe 1. Erst-Gutachterin/Gutachter: Prof. Dr. med. Kirsten Müller-Vahl 2. Gutachterliche Stellungnahme durch: Prof. Dr. rer. nat. Claudia Grothe 3. Gutachterin/Gutachter: Prof Dr. Phil. Florian Beißner Tag der mündlichen Prüfung: 12.07.2017 Promotionsordnung der Medizinischen Hochschule Hannover für die Erlangung des Grades einer Doktorin/eines Doktors der Naturwissenschaften (Doctor rerum naturalium) Letzte Änderung in der 523. Sitzung Senatssitzung vom 15.07.2015 To Seif, Shireen, Farah & Mira . “How can a three-pound mass of jelly that you can hold in your palm imagine angels, contemplate the meaning of infinity, and even question its own place in the cosmos? Especially awe inspiring is the fact that any single brain, including yours, is made up of atoms that were forged in the hearts of countless, far-flung stars billions of years ago. These particles drifted for eons and light-years until gravity and change brought them together here, now. These atoms now form a conglomerate- your brain- that can not only ponder the very stars that gave it birth but can also think about its own ability to think and wonder about its own ability to wonder.
    [Show full text]