Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Indanidine Catalog Number : T11651 CAS Number : 85392-79-6 Molecular Formula : C11H13N5 Molecular Weight : 215.25

Description: Indanidine is an alpha-adrenergic agonist.

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

Receptor (IC50) alpha-adrenergic

In vivo Activity The selective alpha 1-adrenoceptor agonist, Indanidine, also behaved as a partial agonist in the aorta and produced no significant contractions of the small mesenteric artery. Since Idazoxan and Indanidine have been reported to raise blood pressure in the pithed rat via an action at vascular alpha 1-adrenoceptors, these results call into question the reliability of the small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity in vivo.

Reference 1. Van der Graaf PH, et al. Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):389-92.

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