CCES Substance Classification Information

2004

Respecter son sport, c'est se respecter soi-même.

Livret de classification

Booklet des substances Classification Classification

Substance Be true to yourself. Be true to your sport. your to true Be yourself. to true Be 2004

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Athlétisme : CP (Anja Niedringhaus) (Anja CP : Athlétisme

Ski alpin : CP (Christian Landry) (Christian CP : alpin Ski Photos de la page couverture page la de Photos

For further information, please contact: Canadian Centre for Ethics in Sport (CCES) 2197 Riverside Drive, Suite 202

Ottawa, Ontario K1H 7X3

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Cover Photos Alpine Ski: CP (Christian Landry) Athletics: CP (Anja Niedringhaus) Cycling: CP (Kevin Frayer) Bobsleigh: CP/COA (Mike Ridewood) © 2004 Canadian Centre for Ethics in Sport (CCES) Substance Classification Booklet – 2004 www.cces.ca

Helping Athletes Compete Doping-Free The Canadian Centre for Ethics in Sport (CCES) promotes ethical conduct in all aspects of sport in Canada. It is a distinct privilege to be able to contribute to the value of sport in this way. Through its work the CCES seeks to ensure that sport makes a positive contribution to individuals and communities in Canadian society. To truly safeguard the value of sport however, all of us share an obligation to promote ethical values in sport. Together we have a responsibility to ensure that our sport system is one in which all Canadians can share a sense of trust, confidence, respect and pride as we pursue athletic excellence.

The CCES is committed to promoting a fair and doping-free sport environment for all Canadian athletes. We believe that athletes compete because they love their sport, they respect the game and they want to achieve excellence. Collectively, Canadian athletes have called on the CCES to provide services and programs to achieve fair and ethical sport.

This booklet provides athletes and their support personnel with a complete overview of the 2004 World Anti-Doping Agency (WADA) Prohibited List and its application to the Canadian Anti-Doping Program. The information in this publication is provided for reference purposes only. The prohibited categories and lists of examples in this booklet are subject to change by WADA. WADA may and does make modifications to the Prohibited List periodically.

All athletes are responsible for ensuring that they comply with the rules and regulations of competition, which include any sport federation restrictions and the WADA Prohibited List. If you are in doubt about any substance or product avoid its use.

The CCES provides information services to any individual or organization seeking to know whether or not a particular substance or method is prohibited for use in sport. Please note, however, that the CCES does not “clear” or “endorse” consumer products for consumption by Canadian athletes.

If you are ever unsure or have any questions about a substance, please contact the CCES for further information.

i Substance Classification Booklet – 2004 www.cces.ca

Table of Contents

Permitted Substances ...... 1 √

The 2004 WADA Prohibited List ...... 17 x

Prohibited Substances ...... 25 x TUE Therapeutic Use Exemption (TUE) ...... 35

Supplements ...... 39 e

Some helpful hints: • For suggestions on permitted medications, consult the Permitted Substances list.

• When you’ve been prescribed a medication: 1. Verify with your physician or pharmacist that it is not in the Prohibited Substances list. 2. You should always double-check your medication by consulting the Permitted Substances list.

• Please be advised that neither the Permitted nor the Prohibited Substances lists include nutritional supplements, vitamins, herbal products, etc.

• Still unsure? Contact the CCES at 1-800-672-7775 or [email protected]

ii Substance Classification Booklet – 2004 Permitted Substances

Permitted Substances It is important to know that most substances are not prohibited and therefore are available if needed to treat a justifiable medical condition. Substances in this category may be √ prescription or non-prescription medications. This list is not complete but is meant to give you some suggestions of what is permitted. Generic medications are often named by the abbreviation of the company followed by the chemical name of the substance. For example: Apo-, Gen-, Lin-, Novo-, Nu-, PMS-, Rho-, Rhoxal, Riva-, Scheinpharm-, and Taro-. For instance, Apo-Salbutamol is salbutamol.

Please note: This list should not be taken as a recommendation concerning the relative efficacy of various substances or as a recommendation to use them. There are other permitted substances not listed here. Check with your physician, pharmacist, or the CCES for additional information.

This list provides examples of permitted substances in the following categories:

Acne Therapy Antispamodics Anaesthetics (local) Antivirals Analgesics/Anti-inflammatories Anxiolytics/Sedatives Antacids Contraceptives Anti-anginals Cough and Cold Preparations Antiarrhythmics Creams/Ointments/Lotions Antiasthmatics/Bronchial Anti- Decongestants inflammatories Eye/Ear Antibiotics/Antibacterials Gastric Ulcer Anticonvulsants Laxatives Antidepressants Lozenges (Throat) Antidiabetics Mania Therapy Antidiarrheals Muscle Relaxant Antifungals Premenstrual Syndrome and Antihistaminics Dysmenorrhea Antihypertensives Sedatives Anti-inflammatories Smoking Cessation Aids Antimigraine Vaginal Antinauseants/Antiemetics Other Various Medications Antiparasitic Anthelmintics Antimalarials Antiprotozoals

1 Substance Classification Booklet – 2004 Permitted Substances

ACNE THERAPY Mepivacaine (Carbocaine, Polocaine) Accutane Roche (isotretinoin) Prilocaine (Citanest, Novocain) Acetoxyl (benzoyl peroxide) Prilocaine (Emla cream and patch) √ Adapalene Ropivacaine (Naropin) Benoxyl (benzoyl peroxide) Tetracaine (Ametop, Pontocaine) Benzac (benzoyl peroxide) Tetracaine (Endospray) Benzagel (benzoyl peroxide) Benzamycin (benzoyl peroxide, ANALGESICS/ANTI-INFLAMMATORIES erythromycin) 222 Tablets (ASA, codeine) Benzoyl Peroxide 642 Tablets (propoxyphene) Clindamycin 692 Tablets (propoxyphene, ASA) Clindoxyl (benzoyl peroxide, clindamycin) Abenol (acetaminophen) Dalacin T Topical Solution (clindamycin) Acetaminophen Diane-35 (cyproterone, ethinylestradiol for Acetylsalicylic acid (ASA) females only) Advil (ibuprofen) Differin (adapalene) Alka Seltzer (ASA, sodium bicarbonate, citric Erythromycin acid) Isotretinoin Alka Seltzer Morning Relief ( ASA, caffeine) Isotrex (isotretinoin) Anacin, -Extra Strength (ASA) Meted (salicylic acid, sulfur) Anaprox (naproxen) Minocycline Ansaid (flurbiprofen) Oxyderm (benzoyl peroxide) Apo-Diclo, -SR (diclofenac) Panoxyl (benzoyl peroxide) Apo-diflunisal Pernox (salicylic acid, sulfur) Apo-Etodolac (etodolac) Retisol-A (tretinoin) Apo-Keto, -E, -SR (ketoprofen) Salicylic Acid Apo-Ketorolac Sans-Acne (ethyl alcohol, erythromycin) Apo-Mefenamic Sebulex (salicylic acid, sulfur) Apo-Napro-Na, -DS (naproxen) Solugel (benzoyl peroxide) Apo-Oxaprozin Staticin (erythromycin) Apo-Sulin (sulindac) Stievamycin (erythromycin, tretinoin) Apo-Tenoxicam Sulfur Arthrotec (diclofenac, misoprostol) Tarazotene Asaphen, -EC (ASA) Tazorac (tazarotene) Aspirin, -Coated (ASA) Tetracycline Atasol plain, -8, -15, -30, codeine Tretinoin (acetaminophen) Triclosan Bextra (valdecoxib) Brexidol 20 (piroxicam) ANAESTHETICS (LOCAL) Celebrex (celecoxib) Articaine (Astracaine, Pontocaine) Coated Aspirin (ASA) Benzocaine (Endospray) Codeine Benzocaine (Auralgan, Anbesol) Codeine Contin Bupivacaine (Marcaine, Sensorcaine) Codeine Phosphate Chloroprocaine (Nesacaine-CE) Darvon-N (propoxyphene) Lidocaine (Xylocaine) Daypro (oxaprozin) Lidocaine (Emla cream and patch) Disalcid (salsalate)

2 Substance Classification Booklet – 2004 Permitted Substances

Emtec-30 (acetaminophen, codeine) Ratio-Benzydamine Entrophen (ASA) Ratio-Codeine Exdol-8, -15, -30 (acetaminophen, codeine) Ratio-Flurbiprofen Feldene (piroxicam) Ratio-Indomethacin √ Fexicam (piroxicam) Ratio-Lenoltec N˚1, 2 & 3 (acetaminophen, Fiorinal (ASA, butalbital, caffeine) caffeine, codeine) Fiorinal C1/4, -C1/2 (ASA, codeine, Ratio-Lenoltec N˚4 (acetaminophen, butalbital) codeine) Froben, -SR (flurbiprofen) Rhodis, -EC, -SR (ketoprofen) Gen-nabumetone Rhoxal-nabumetone Ibuprofen Rhovail (ketoprofen) Idarac (floctafenine) Stadol NS (butorphanol) Indotec (indomethacin) Surgam, -SR (tiaprofenic acid) Mersyndol with codeine (acetaminophen, Synflex, -DS (naproxen) codeine, doxylamine) Tolectin (tolmetin) Mobicox (meloxicam) Toradol (ketorolac) Motrin, -IB (ibuprofen) Triatec-8, -8 strong (acetaminophen, MSD Enteric Coated ASA (ASA) codeine) Nalfon (fenoprofen) Triatec-30 (acetaminophen, codeine) Naprosyn (naproxen) Trilisate (choline salicylate, magnesium Naxen (naproxen) salicylate) Novasen (ASA) Tylenol plain (acetaminophen) Novo-5 ASA (ASA) Tylenol Aches and Strains (acetaminophen, Novo-Flurprofen (flurbiprofen) chlorzoxazone) Novo-Gesic C8, -C15, -C30 (acetaminophen, Tylenol Elixir with codeine (acetaminophen, caffeine, codeine) codeine) Novo-Keto, -EC (ketoprofen) Tylenol with codeine N˚1, -N˚1 Forte, -N˚2, - Novo-Methacin (indomethacin) N˚3 (acetaminophen, caffeine, codeine) Novo-Naprox, -SR, -Sodium, -Sodium DS Tylenol with codeine N˚4 (codeine, (naproxen) acetaminophen) Novo-Pirocam (piroxicam) Ultradol (Etodolac) Novo-Profen (ibuprofen) Vioxx (rofecoxib) Novo-Sundac (sulindac) Voltaren (diclofenac) Novo-Tiaprofenic Voltaren Rapide (diclofenac) Novo-Tenoxicam Novo-Tolmetin ANTACIDS Nu-Diclo, -SR (diclofenac) Amphojel (aluminum) Nu-Indo (indomethacin) Diovol (aluminum, magnesium) Nu-Naprox (naproxen) Gaviscon (aluminum, sodium) Nu-Pirox (piroxicam) Gelusil (aluminum, magnesium) Orafen (ketoprofen) Mylanta (aluminum, magnesium, Orudis SR (ketoprofen) simethicone) Oruvail (ketoprofen) Riopan (magaldrate) Phenaphen with codeine (ASA, codeine, Rolaids Antacid Tablets (magnesium, phenobarbital) calcium) Ponstan (mefenamic acid) TUMS Tablets (calcium) Pyridium (phenazopyridine)

3 Substance Classification Booklet – 2004 Permitted Substances

ANTI-ANGINALS ANTIASTHMATICS/BRONCHIAL ANTI- Apo-ISDN (isosorbide 5-mononitrate) INFLAMMATORIES Cardizem, -SR, -CD (diltiazem) Accolate (zafirlukast) √ Cedocard-SR (isosorbide 5-mononitrate) Aminophylline (theophylline) Chronovera (verapamil) Apo-Cromolyn Sterules (cromolyn sodium) Diltiazem Apo-Ipravent (ipratropium) Imdur (isosorbide 5-mononitrate) Apo-oxtripylline (theophylline) Ismo (isosorbide 5-mononitrate) Apo-Theo LA (theophylline) Isoptin (verapamil) Atrovent (ipratropium) Isordil (isosorbide 5-mononitrate) Choledyl (theophylline) Minitran (nitroglycerin) Choledyl Expectorant (theophylline, Nitro-Dur (nitroglycerin) guaifenesin) Nitrolingual Pumpspray (nitroglycerin) Intal (sodium cromoglycate) Nitrong SR (nitroglycerin) Novo-Theophyl-SR (theophylline) Nitrostat (nitroglycerin) Quibron T SR (theophylline) Norvasc (amlodipine) Singulair (montelukast) Novo-Nifedin (nifedipine) Theo-Bronc (theophylline, guaifenesin, Novo-Veramil, SR (verapamil) mepyramine) Nu-Diltiaz, -CD (diltiazem) Theochron SR (theophylline) Nu-Nifed (nifedipine) Theo-Dur (theophylline) Nu-Verap (verapamil) Theolair, -SR (theophylline) Transderm-Nitro (nitroglycerine) Theophylline Tilade (nedocromil) ANTIARRHYTHMICS Vaponefrin (epinephrine) Adenocard (adenosine) Amiodarone Hydrochloride for I.V. infusion ANTIBIOTICS/ANTIBACTERIALS Apo-Procainamide * All antibiotics are permitted Apo-Quinidine Ampicillin Biquin Durules (quinidine) Apo-Amoxi (amoxicillin) Bretylium Tosylate Injection USP Apo-Amoxi-Clav (amoxillin/clavulanate Cardioquin (quinidine) potassium) Cardizem injectable (diltiazem) Apo-Ampi (ampicillin) Cordarone (amiodarone) Apo-Cefaclor (cefaclor) Isoptin (verapamil) Apo-Cefadroxil Mexitil (mexiletine) Apo-Cephalex (cephalexin) Novo-Mexiletine Apo-Cloxi (cloxacillin) Novo-Veramil, -SR (verapamil) Apo-Cefuroxime Nu-Verap (verapamil) Apo-Doxy (doxycycline) Procan (procainamide) Apo-Erythro-Base, -EC,-S,-ES Pronestyl, -SR (procainamide) (erythromycin) Quinidine Apo-Metronidazole Ratio- Amiodarone Apo-Nitrofurantoin Rythmodan, -LA (disopyramide) Apo-Norflox (norfloxacin) Rythmol (propafenone) Apo-Oflox (ofloxacin) Tambocor (flecainide) Apo-Pen VK (penicillin) Apo-Sulfatrim (trimethoprim,

4 Substance Classification Booklet – 2004 Permitted Substances

sulfamethoxazole) Mandelamine (methamine) Apo-Trimethoprim Maxipime (cefepime) Apo-Tetra (tetracycline) Mefoxin (cefoxitin) Avlosulfon (dapsone) Merrem (meropenem) √ Bacitracin Metronidazole Injection Biaxin (clarithromycin) Minocin (minocycline) Ceclor (cefaclor) Mycobutin (rifabutin) Cefazolin Mycostatin (nystatin) Cefizox (ceftizoxime) Nadopen-V (penicillin) Cefotan (cefotetan) Nebcin (tobramycin) Cefoxitin Neg Gram (nalidixic acid) Ceftin (cefuroxime axetil) Nemasol Sodium Ceptaz (ceftazidime) Netromycin (Netilmicin Sulfate) Ceporacin (cephalothin) Noroxin (norfloxacin) Chloromycetin injection (cloramphenicol) Novamoxin (amoxicillin) Ciloxan (ciprofloxazin) Novo-Furatoin (nitrofurantoin) Claforan (cefotaxime) Novo-Lexin (cephalexin) Clavulin (amoxicillin/clavulanate potassium) Novo-Pen-VK (penicillin) Cloxacillin Novo-Rythro Encap (erythromycin) Coly-Mycin (sodium colistimethate) Novo-Trimel (trimethoprim, Coptin (sulfadiazine, trimethoprim) sulfamethoxazole) Crystapen (penicillin) Nu-tetra (tetracycline) Dalacin (clindamycin) Nyaderm (nystatin) Declomycin (demeclocycline) PCE (erythromycin) Doxycin (doxycycline) Penicillin Doxytec (doxycycline) Penglobe (bacampicillin) Duricef (cefadroxil) Pipracil (piperacillin) EES (erythromycin) PMS-Polytrimethoprim (trimethoprim, Erybid (erythromycin) sulfamethoxazole) Eryc (erythromycin) Pondocillin (pivampicillin) Erythrocin, -IV (erythromycin) Primaxin (imipenem, cilastatin) Erythromid (erythromycin) PVF K (penicillin) Florazole (metronidazole) Rocephin (ceftriaxone) Floxin (ofloxacin) Rovamycine (spiramycin) Fortaz (ceftazidime) Selexid (pivmecillinam) Fucidin, -IV (sodium fusidate) Septra-DS, -Injection (polymyxin, Garamycin Parental (gentamicin) trimethoprim) Gentamycin Injection USP SSD (silver sulfadiazine) Gentamycin Sulfate Injection Streptomycin Sulfate Humatin (paromonycin) Suprax (cefexime) Keflex (cephalexin hydrochloride) Synercid (quinupristin, dalfopristin) Kefurox (cefuroxime) Tazidime (ceftazidine) Kefzol (cefazolin) Tazocin (piperacillin, tazobactam) Levaquin (levofloxacin) Timentin (ticarcillin) Lincocin (lincomycin) Tobramycin sulfate injection USP Macrobid (nitrofurantoin) Zithromax (azithromycin) Macrodantin (nitrofurantoin) Z-Pak (zithromax, azithromycin)

5 Substance Classification Booklet – 2004 Permitted Substances

ANTICONVULSANTS Luvox (fluvoxamine) Apo-Carbamazepine Manerix (moclobemide) Apo-Clonazepam Nardil (phenelzine) √ Apo-Divalproex Norpramin (desipramine) Apo-Gabapentin Norventyl (nortriptyline) Apo-Primidone Novo-Maprotiline Celontin (methsuximide) Novo-Tripramine (trimipramine) Clonapam (clonazepam) Parnate (tranylcypromine) Depakene (valproic acid) Paxil (paroxetine) Dilantin (phenytoin) Prozac (fluoxetine) Epival (valproic acid) Rhotrimine (trimipramine) Epiject I.V. (valproic acid) Risperdal (risperidone) Frisium (clobazam) Seroquel (quetiapine) Lamictal (lamotrigine) Sinequan (doxepin) Mysoline (primidone) Surmontil (trimipramine) Neurontin (gabapentin) Tofranil (imipramine) Novo-Carbamaz (carbamazepine) Triavil (amitriptyline, perphenazine) Phenobarbital Triptil (protriptyline) Ratio-Valproic (valproic acid) Wellbutrin-SR (bupropion) Tegretol (carbamazepine) Zoloft (sertraline) Valium Zarontin (ethosuximide) ANTIDIABETICS Albert Glyburine ANTIDEPRESSANTS Avandia (rosiglitazone) Amineptine Diabinese (chlorpropamide) Anafranil (clomipramine) DiaBeta (glyburide) Apo-Amitriptyline Diamicron (gliclazide) Apo-Clomipramine Euglucon (glyburide) Apo-Desipramine GlucoNorm (repaglinide) Apo-Doxepin Glucophage (metformin) Apo-Fluoxetine Prandase (acarbose) Apo-Fluvoxamine Sulfonylureas (chlorpropamide, gliclazide, Apo-Imipramine glimepiride, glyburide, tolbutamide) Apo-Moclobemide Apo-Nortriptyline ANTIDIARRHEALS Apo-Sertraline DDAVP (desmopressin acetate) Apo-Trazodone Gastrolytes (electrolytes, dextrose) Apo-Trimip (trimipramine) Imodium (loperamide) Asendin (amoxapine) Imodium Advanced (loperamide, Aventyl (nortriptyline) simethicone) Celexa (citalopram hydrobromide) Kaopectate (attapulgite) Desyrel (trazodone) Lomotil (diphenoxylate) Effexor, -XR (venlafaxine) Loperacap (loperamide) Elavil (amitriptyline) Maalox (aluminum, magnesium, Etafron (amitriptyline, perphenazine) simethicone) Ludiomil (maprotiline) Pepto Bismol (bismuth subsalicylate)

6 Substance Classification Booklet – 2004 Permitted Substances

ANTIFUNGALS (acetaminophen, diphenhydramine, Antibiotics pseudoephedrine) Apo-Fluconazole Benadryl Extra Strength Nightime Apo-Ketoconazole (diphenhydramine) √ Candistatin (nystatin) Brompheniramine Canesten (clotrimazole) Caladryl (calamine, diphenhydramine) Dequadin Oral Paint (dequalinium) Calmylin nº4 (dextromethorphan, Diflucan, –150 (fluconazole) diphenhydramine) Ecostatin (econazole) Chlorpheniramine Fulvicin U/F (griseofulvin) Chlor-Tripolon (chlorpheniramine) Fungizone (amphotericin) Chlor-Tripolon Decongestant Lamisil (terbinafine) (chlorpheniramine, pseudoephedrine) Loprox (ciclopirox) Chlor-Tripolon ND (loratidine, Micatin (miconazole) pseudoephedrine) Monistat (miconazole) Claritin plain (loratadine) Mycostatin (nystatin) Claritin Extra (loratidine, pseudoephedrine) Nilstat (nystatin) Claritin Liberator (loratidine, Nizoral (ketoconazole) pseudoephedrine) Nyaderm (nystatin) Coricidin (chlorpheniramine, ASA) Oxizole (oxiconazole) Diphenhydramine Ratio-Nystatin Dristan, Extra Strength (acetaminophen, Sporanox (itraconazole) pheniramine, phenylephrine) Trosyd AF, -J (tioconazole) Drixoral (dexbrompheniramine, ZeaSORB (chloroxylone) pseudoephedrine) ZeaSORB AF (tolnaftate) Emadine (emedastine) Epinephrine Epipen (epinephrine) ANTIHISTAMINICS Loratidine See also Cough and Cold Preparations and Optimine (azatadine) Decongestants Panectyl (trimeprazine) Actifed Tablets (triprolidine, Periactin (cyproheptadine) pseudoephedrine) Phenergan tablets (prometazine) Adrenalin (epinephrine) Polaramine (dexchlorpheniramine) Aerius (desloratadine) Promethazine Hydrochloride Injection USP Albalon-A Liquidfilm (antazoline, Reactine (cetirizine) naphazoline) Sinutab Sinus and Allergy, Extra Strength Allegra 12h, 24h (fexofenadine) (acetaminophen, chlorpheniramine, Allegra D (fexofenadine, pseudoephedrine) pseudoephedrine) Allernix (diphenhydramine) Vaponefrin (epinephrine) Allerdyl (diphenhydramine) Zaditen (ketotifen) Apo-Cetirizine Zyrtec (cetirizine) Apo-Loratadine Atarax (hydroxyzine) ANTIHYPERTENSIVES Benadryl (diphenhydramine) Adalat (nifedipine) Benadryl Allergy/Sinus/Headache Altace (ramipril)

7 Substance Classification Booklet – 2004 Permitted Substances

Apo-Clonidine Indocid P.D.A. (indomethacine) Apo-Diltiaz Indocin (indomethacine) Apo-Hydralazine Mesasal (ASA enteric coated) √ Apo-Methyldopa Pentasa (5-ASA) Apo-Nifed PA (nifedipine) Plaquenil (hydroxychloroquine) Apo-Verap (verapamil) Quintasa (5-ASA) Apresoline (hydralazine) Ratio-Sulfasalazine Atacand (candesartan cilexetil) Relafen (nabumetone) Avapro (irbesartan) Salazopyrin, En-Tabs (sulfasalazine) Capoten (captopril) Salofalk (5-ASA) Catapres (clonidine) Chronovera (verapamil) ANTIMIGRAINE Coversyl (perindopril) Amerge (naratriptan) Cozaar (losartan) Cafergot, -PB (belladonna) Diovan (valsartan) Dihydroergotamine (DHE) Hyperstat IV Injection (diazoxide) Ergodryl (ergotamine) Inhibace (cilazapril) Ergomar (ergotamine) Isoptin (verapamil) Fiorinal (ASA, butalbital) Loniten (minoxidil) Fiorinal –C1/4, -C1/2 (ASA, codeine, Lotensin (benazepril) butalbital) Mavik (trandolapril) Gravergol (ergotamine, dimenhydramine) Micardis (telmisartan) Imitrex (sumatriptan) Minipress (prazosin) Maxalt, -RPD (rizatriptan) Monopril (fosinopril) Megral (ergotamine, cyclizine) Nifedipine PA Migranal (dihydroergotamine) Nipride (sodium nitroprusside) Ratio-Tecnal (ASA, butalbital) Novo-Hylazin (hydralazine) Ratio-Tecnal –C1/4, -C1/2 (ASA, butalbital, Novo-Veramil, -SR (verapamil) codeine) Nu-Capto (captopril) Sandomigran, -DS (pizotifen) Nu-Diltiaz-CD (diltiazem) Sansert (methylsergide) Nu-Hydral (hydralazine) Trianal –C1/4, -C1/2 (ASA, codeine, Nu-Prazo (prazosin) butalbital) Nu-Verap (verapamil) Zomig (zolmitriptan) Plendil (felodipine) Prinivil (lisinopril) Ratio-Captopril ANTINAUSEANTS/ANTIEMETICS Verelan (verapamil) Anzemet (dolasetron) Zestril (lisinopril) Apo-Dimenhydrinate Apo-Metoclop (metoclopramide) ANTI-INFLAMMATORIES Biltricide (prazinquantel) Bonamine (meclizine) (All non-steroidal anti-inflammatories are Cesamet (nabilone) permitted) Dimenhydrinate (suppositories, injection) Apo-Nabumetone Dimenhydrinate Injection, -USP Apo-Phenylbutazone Gravol (dimenhydrinate) Asacol (5-ASA) Kytril (granisetron) Dipentum (olsalazine) Metoclopramide Hydrochloride Injection

8 Substance Classification Booklet – 2004 Permitted Substances

Metoclopramide Omega Injection DPT Polio Vermox (mebendazole) DT Polio Zofran, -ODT (odansetron) Famvir (famciclovir) Flu vaccine √ ANTIPARASITIC Herplex-D (idoxuridine) Immunization Injections (Hepatitis, typhoid, ANTHELMINTICS tetanus) Combantrin (pyrantel pamoate) Relenza (zanamivir) Entacyl (piperazine) Symmetrel (amantadine) Tamiflu (oseltamivir) ANTIMALARIALS Twinrix Aralen (chloroquine) Valtrex (valacyclovir) Daraprim (pyrimethamine) Virazole (ribavirin) Lariam (mefloquine) Zovirax Oral (acyclovir) Malarone (atovaquone) Paludrine (proguanil) ANXIOLYTICS/SEDATIVES Plaquenil (hydroxychloroquine) Primaquine Apo-Buspirone Quinine Sulfate Apo-Chlorax (chlordiazepoxide) Apo-Clorazepate ANTIPROTOZOALS Apo-Diazepam Flagyl (metronidazole) Apo-Hydroxyzine Florazole (metronidazole) Apo-Lorazepam Mepron (atovaquone) Atarax (hydroxyzine) Pentacarinat (pentamidine) Ativan (lorazepam) BuSpar (buspirone) Buspirex (buspirone) ANTISPAMODICS Bustab (buspirone) Albert Oxybutynin Diazemuls (diazepam) Apo-Oxybutynin Imovane (zopiclone) Apo-Trihex (trihexyphenidyl) Librax (chlordiazepoxide) Bentylol (dicyclomine) Ratio-Alprazolams Buscopan (hyoscine) Serax (oxazepam) Detrol (tolterodine) Valium Roche Oral (diazepam) Ditropan (oxybutynin) Formulex (dicyclomine) CONTRACEPTIVES Kemadrin (procyclidine) Levsin (hyoscyamine) All oral contraceptives, as well as the Depo- Lomine (dicyclomine) Provera injection, are permitted in females. Oxybutyn (oxybutynin) Unidet (tolterodine-tartrate) Urispas (flavoxate) COUGH AND COLD PREPARATIONS See also Antihistaminics, Decongestants ANTIVIRALS and Lozenges Acyclovir Balminil Codeine + Decongestant + Combivir (lamivudine, zidovudine) Expectorant (codeine, guaifenesin, Cytovene (ganciclovir) pseudoephedrine)

9 Substance Classification Booklet – 2004 Permitted Substances

Balminil Codeine Night-Time + Expectorant Dimetane Expectorant-C (brompheniramine, (codeine, diphenhydramine, ammonium codeine, guaifenesin, phenylephrine) chloride) Dimetapp Cold Liquid (brompheniramine, √ Balminil Cough & Flu (acetaminophen, phenylephrine) dextromethorphan, guaifenesin, Dimetapp-C Syrup (brompheniramine, pseudoephedrine) codeine, phenylephrine) Balminil DM (dextromethorphan) Dimetapp Cough & Congestion Liquid Balminil DM + Decongestant (dextromethorphan, guaifenesin, (dextromethorphan, pseudoephedrine) pseudoephedrine) Balminil DM + Expectorant Dimetapp Daytime Cold, Extra Strength (dextromethorphan, guaifenesin) (acetaminophen, pseudoephedrine) Balminil DM + Decongestant + Expectorant Dimetapp DM Cough & Cold Liquid (dextromethorphan, guaifenesin, (brompheniramine, dextromethorphan, pseudoephedrine) phenylephrine) Balminil Expectorant (guaifenesin) Dimetapp Nighttime Cold, Extra Strength Benylin 4 Flu (acetaminophen, (acetaminophen, chlorpheniramine, dextromethorphan, guaifenesin, phenylephrine) pseudoephedrine) Formula 44 D (dextromethorphan, Benylin DM (dextromethorphan) pseudoephedrine) Benylin DM-D (dextromethorphan, Guaifenesin pseudoephedrine) Hycodan (hydrocodone) Benylin DM-D-E, Extra Strength Hycomine, -S (hydrocodone, phenylephrine) (dextromethorphan, guaifenesin, Hydrocodone pseudoephedrine) Koffex DM (dextromethorphan) Benylin DM-E, Extra Strength Neo Citran, Extra Strength (acetaminophen, (dextromethorphan, guaifenesin) pheniramine, phenylephrine) Benylin E Extra Strength (guaifenesin) Neo Tuss (chlorpheniramine, Benylin First Defense (ecchinacea, menthol) dextromethorphan, guaifenesin, Buckley’s Cough, Cold & Flu Daytime Relief phenylephrine) Extra Strength (acetaminophen, Novahistex DH (hydrocodone, dextromethorphan, pseudoephedrine) phenylephrine) Buckley’s DM (dextromethorphan, Phenylephrine pseudoephedrine) Pseudoephedrine Calmylin with Codeine (codeine, Ratio-Coristex DH (phenylephrine, guaifenesin, pseudoephedrine) hydrocodone) Cheracol (codeine, guaifenesin) Ratio Cotridin (tripolidine, pseudoephedrine, Codeine codeine) Codeine Phosphate Ratio Cotridin Expextorant (tripolidine, Contac Cough, Cold & Flu Day pseudoephedrine, codeine, guaifenesin) (acetaminophen, dextromethorphan, Robitussin, Extra Strength (guaifenesin) pseudoephedrine) Robitussin AC (codeine, guaifenesin, Contac Head & Chest Congestion pheniramine) (guaifenesin, pseudoephedrine) Robitussin Honey Cough & Cold Dayquil (acetaminophen, dextromethorphan, (dextromethorphan, pseudoephedrine) pseudoephedrine) Robitussin Honey Cough DM Delsym (dextromethorphan) (dextromethorphan) Dextromethorphan Robitussin Honey Flu (acetaminophen,

10 Substance Classification Booklet – 2004 Permitted Substances

dextromethorphan, pseudoephedrine) Strength (acetaminophen, Robitussin Cough & Cold, Liqui-Gels, Extra chlorpheniramine, dextromethorphan, Strength (dextromethorphan, guaifenesin, pseudoephedrine) pseudoephedrine) Tylenol Cold Caplets –chest congestion √ Robitussin Cough, Cold & Flu Liqui-Gels (acetaminophen, dextromethorphan, (acetaminophen, dextromethorphan, guaifenesin, pseudoephedrine) guaifenesin, pseudoephedrine) Tylenol Cough (acetaminophen, Robitussin DM, Extra Strength dextromethorphan) (dextromethorphan, guaifenesin) Tylenol Decongestant (acetaminophen, Sinutab Sinus Non Drowsy (acetaminophen, pseudoephedrine) pseudoephedrine) Tylenol Flu (acetaminophen, Sudafed Cold & Cough Extra Strength dextromethorphan, pseudoephedrine) (acetaminophen, dextromethorphan, pseudoephedrine) CREAMS/OINTMENTS/LOTIONS Sudafed Cold & Flu (acetaminophen, Bengay Arthritis Extra Strength (methyl dextromethorphan, guaifenesin, salicylate, menthol) pseudoephedrine) Bengay Ice Extra Strength (menthol) Sudafed Head Cold & Sinus Extra Strength Bengay Muscle Pain Regular Strength (acetaminophen, pseudoephedrine) (methyl salicylate, menthol) Triaminic Cold & Cough (chlorpheniramine, Bengay Muscle Pain Ultra Strength (methyl dextromethorphan, pseudoephedrine) salicylate, menthol,camphor) Triaminic Cold, Cough & Fever Clotrimaderm (clotrimazole) (acetaminophen, chlorpheniramine, Dermatix Fitocream (extract of T. vulgare) dextromethorphan, pseudoephedrine) Dermatix Si Gel ( polyliloxane, silicone Triaminic Cold & Night Time Cough dioxide) (chlorpheniramine, dextromethorphan, Fucidin (fusidic acid) pseudoephedrine) Garamycin Topical Preparations Triaminic Cough & Congestion Gentamycin Sulfate (dextromethorphan, pseudoephedrine) Ketoderm (ketokonazole) Triaminic Cough & Sore Throat Lidosporin Cream (polymyxin B, gramicidin, (acetaminophen, dextromethorphan, lidocaine) pseudoephedrine) MetroCream (metronidazole) Triaminic Softchews Cold & Cough MetroGel (metronidazole) (chlorpheniramine, dextromethorphan, Myoflex (triethanolamine salicylate) pseudoephedrine) Neosporin Ointment (polymyxin B) Triaminic Softchews Throat Pain & Cough Neotopic (polymyxin B, neomycin) (acetaminophen, dextromethorphan, Noritate (metronidazole) pseudoephedrine) Ozonol Preparations (Polymyxin B sulphate, Triaminic Vapor Patch (camphor, menthol, bacitracin, lidocaine) eucalyptus oil) Pennsaid (diclofenac) Tylenol Cold Caplets (Daytime), - Extra Polysporin Preparations (polymyxin B, Strength (acetaminophen, gramicidin or bacitracin) dextromethorphan, pseudoephedrine) Polysporin Plus Pain Relief Cream Tylenol Cold & Flu Nightime Relief (polymyxin B, gramicidin, lidocaine) (acetaminophen, chlorpheniramine, Prevex (petrolatum) dextromethorphan, pseudoephedrine) Ratio-Gentamicin Tylenol Cold Caplets Nighttime, Extra

11 Substance Classification Booklet – 2004 Permitted Substances

Sarna-P (pramoxine) Vicks Sinez decongestant (oxymetazoline) Spectro Gram “2” (chlorhexidine) Xylometazoline Sun-Benz (benzydamine) Zincfrin –A (antazoline, naphazoline) √ Tantum (benzydamine) Zincfrin (phenylephrine) Teejel (choline salicylate) Zovirax Cream, Ointment (acyclovir) EYE/EAR Alcomicin (gentamycin) DECONGESTANTS Alocril (nedocrimil sodium) See also Antihistaminics and Cough and Alomide (lodoxamide) Cold Preparations Auralgan (antipyrine, benzocaine) Cetamide (sulfacetamide) Advil Cold and Sinus (ibuprofen, Cromolyn pseudoephedrine) Diochloram (chloramphenicol) Apo-Cromolyn Nasal Spray Diogent Ointment solution (gentamycin) Buckley’s Sinus pain relief (acetaminophen, Diomycin (erythromycin) pseudoephedrine) Diopentolate (cyclopentolate) Dayquil Sinus and Pain Relief Diophenyl-T (phenylephrine, tropicamide) (acetaminophen, pseudoephedrine) Diosulf (sulfacetamide) Decongestant Nasal Mist/Spray Diotrope (tropicamide) (xylometazoline) Duratears Naturale Dristan Long Lasting Nasal Mist/Spray Erythromycin (oxymetazoline) Eyestil (sodium hyaluronate) Dristan Nasal Mist/Spray, Mentholated Eye-Stream (salt solution) (pheniramine, phenylephrine) Garamycin Opthalmic Otic Prep. Dristan ND, Extra Strength (acetaminophen, (gentamicin) pseudoephedrine) Garasone Ophtalmic/Otic Prep. (gentamicin) Dristan Sinus (ibuprofen, pseudoephedrine) Garatec (gentamicin) Drixoral Decongestant Nasal Spray Gentamicin Sulfate (oxymetazoline) Genteal Livostin Nasal Spray (levocabastine) Hypotears Eye Ointment Mydfrin (phenylephrine) Hypotears Ophthalmic S/L Neo Citran Extra Strength Sinus Isopto Tears (acetaminophen, phenylephrine) Lacrinorm Otrivin Decongestant Nose Drops/Nasal Lidosporin Ear Drops Spray (xylometazoline) Lid-Pack Pseudoephedrine Liquifilm Tears Rhinaris Lubricating (polyethylene, Livostin Eye Drops (levocabastine) propylene) Naphcon (naphazoline) Rhinaris Saline Solution (sodium) Naphcon-A (naphazoline, pheniramine) Salinex Naphcon Forte (naphazoline) Salinol Neosporin Preparations (polymyxin B) Secaris (carbowax, propylene) Noroxin Ophtalmic Solution (norfloxaxin) Sudafed Decongestant (pseudoephedrine) Ocufen (flurbiprofen) Tylenol Decongestant (acetaminophen, Ocuflox (ofloxacin) pseudoephedrine) Opticrom (sodium cromoglycate) Tylenol Sinus, Extra Strength Optimyxin, -Plus (polymyxin B) (acetaminophen, pseudoephedrine)

12 Substance Classification Booklet – 2004 Permitted Substances

Patanol (olopatadine) Zantac (ranitidine) Pentamycetin (chloramphenicol) PMS-Tobramycin LAXATIVES Polycidin Eye/Ear Drops (polymyxin B, Apo-Bisacodyl √ gramicidin) Colace (docusate sodium) Polycidin Ophtalimic Ointment (polymyxin B, Dulcolax (bisacodyl) bacitracin) Duphalac (lactulose crystals) Polysporin (antibiotic) Ex-lax (sennosides) Polytrim (trimethoprim, polymyxin B) Glycerin suppositories Refresh Plus Tears Klean-Prep Sodium Sulamyd (sulfacetamide) Lansoÿl (mineral oil) Tobramycin Maalox (aluminum, magnesium, Tobrex (tobramycin) simethicone) Tomycine (tobramycin) Metamucil (psyllium hydrophilic) Vasocon (naphazoline) Normacol (sterculia) Visine Allergy Eye Drops (tetrahydrozoline, Novo-Mucilax (plantago seed) zinc sulfate) Peri-Colace (docusate) Voltaren Optha (diclofenac) Phosphates Solution VoSol (benzethonium chloride) PMS-Sennosides Senokot Preparation (sennosides) GASTRIC ULCER Apo-Cimetidine LOZENGES (THROAT) Apo-Nizatidine Antiseptic Throat Lozenges (hexylresorcinol) Apo-Ranitidine Bentasil Lozenges (anethole, menthol, Axid (nizatidine) eucalyptus) Carafate (sucralfate) Benylin First Defense (Echinacea, menthol) Glycopyrrolate Bradosol (4-hexylresorcinol) Losec (omeprazole) Cepacol (cetylpyridinium) Losec 1-2-3-A (omeprazole, amoxicillin, Cepastat Lozenges (phenol) clarithromycin) Dequadin Lozenges (dequalinium) Losec 1-2-3-M (omeprazole, clarithromycin, Fisherman’s Friend (menthol) metronidazole) Halls (eucalyptus oil, menthol) Nexium (esomeprazole) Strepsils (hexylresorcinol) Novo-Famotidine (famotidine) Sucrets (dyclonine) Novo-Misoprostol Nu-Cimet (cimetidine) Nu-Ranit (ranitidine) MANIA THERAPY Panto IV (pantoprazole) LITHIUM SALTS Pantoloc (pantoprazole) Carbolith Pariet (rabeprazole) Duralith Pepcid AC (famotidine) Lithane Pepcid, IV (famotidine) Lithium Prevacid (lansoprazole) Pylorid (ranitidine) MUSCLE RELAXANT Tagamet (cimetidine) 282 MEP (ASA, meprobamate) Ulcidine (famotidine) Acetazone Forte (acetaminophen,

13 Substance Classification Booklet – 2004 Permitted Substances

chlorzoxazone) Tylenol Menstrual (acetaminophen, Acetazone C8 (acetaminophen, pamabrom, pyrilamine) chlorzoxazone, codeine) √ Apo-Baclofen SEDATIVES Apo-Cyclobenzaprine Apo-Alpraz (alprazolam) Aspirin Backache (ASA, methocarbamol) Apo-Bromazepam Dantrium Capsules (dantrolene) Nembutal (pentobarbital) Flexeril (cyclobenzaprine) Novo-Alprazol (alprazolam) Glycopyrrolate Nu-Alpraz (alprazolam) Lioresal (baclofen) Nu-Loraz (lorazepam) Liotec (baclofen) Nytol plain, Extra Strength Methoxacet (methocarbamol, (diphenhydramine) acetaminophen) PMS-Chloral Hydrate Methoxacet-C (methocarbamol, Serax (oxazepam) acetaminophen, codeine) Starnoc (zaleplon) Methoxisal (methocarbamol, ASA) Tranxene (clorazepate) Methoxisal-C (methocarbamol, ASA, Unisom Extra Strength/Extra Strength codeine) Sleepgels (diphenhydramine) Norflex (orphenadrine) Valium Roche Oral (diazepam) Norgesic, -Forte (orphenadrine, ASA) Novo-cycloprine (cyclobenzaprine) Nu-Baclo (baclofen) SMOKING CESSATION AIDS Parafon Forte (acetaminophen and Habitrol (nicotine) chlorzoxazone) Nicoderm (nicotine) Ratio-Baclofen Nicorette, -Plus (nicotine) Ratio-Cyclobenzaprine Nicotrol (nicotine) Robaxacet, -Extra Strength (methocarbamol, Zyban (bupropion) acetaminophen) Robaxin, -750 (methocarbamol) VAGINAL Robaxisal, -Extra Strength (methocarbamol, AVC (sulphanilamide) ASA) Betadine (povidone iodine) Robaxisal-C (methocarbamol, ASA, codeine) Canesten Vaginal (clotrimazole) Soma (carisoprodol) Clotrimaderm (clotrimazole) Tylenol Aches and Strains (acetaminophen, Dolacin Vaginal Cream (clindamycin) chlorzoxazone) Flagyl (metronidazole) Flagystatin (metronidazole, nystatin) PREMENSTRUAL SYNDROME AND Gynecure (tioconazole) DYSMENORRHEA Micozole (miconazole) Midol Regular, -Traditional (ASA, caffeine) Monazole-7 (miconazole) Midol Extra Strength (acetaminophen, Monistat (miconazole) caffeine, pyrilamine) Mycostatin (nystatin) Midol PMS Extra Strength (acetaminophen, Nidagel (metronidazole) pamabrom, pyrilamine) Nilstat (nystatin) Pamprin, -Extra Strength, -PMS Nyaderm (nystatin) (acetaminophen, pyrilamine, pamabrom) Terazol (terconazole)

14 Substance Classification Booklet – 2004 Permitted Substances

Other Various Medications Amatine (midodrine) Duofilm (salicylic acid) Eltroxin (levothyroxine) √ Enbrel (etanercept) Imuran (azathioprine) Synthroid (levothyroxine)

Substance Classification Booklet – 2004 2004 WADA Prohibited List

The 2004 WADA Prohibited List The World Anti-Doping Agency (WADA) seeks to foster a doping-free culture in sport. It combines the resources of sport and government to enhance, supplement and coordinate existing efforts to educate athletes about the harms of doping, reinforce the ideal of fair play and sanction those who cheat themselves and their sport.

WADA created the World Anti-Doping Program which encompasses all the elements needed in order to ensure optimal harmonization and best practice in international and national anti-doping programs. It includes three main elements: The World Anti-Doping Code, International Standards and Models of Best Practices. The purposes of the World Anti-Doping Program and the World Anti-Doping Code are: x – To protect athletes’ fundamental right to participate in doping-free sport and thus promote health, fairness and equality for athletes worldwide; and – To ensure harmonized, coordinated and effective anti-doping programs at the international and national level with regard to detection, deterrence and prevention of doping.

International Standards are developed for different technical and operational areas within an anti-doping program and their purpose is harmonization among Anti-Doping Organizations (ADO), such as the CCES and international sport federations, responsible for specific technical and operational parts of anti-doping programs. The International Standard for the Prohibited List was developed by the WADA List and Health, Medical and Research Committees based on extensive input from Signatories (entities signing the Code and agreeing to comply with the Code) and governments.

The principal purpose of the WADA Prohibited List is to establish under the rules of the World Anti-Doping Code the substances and methods which are prohibited in sport.

The Code (4.3) states: “4.3 WADA shall consider the following criteria in deciding whether to include a substance or method on the Prohibited List. 4.3.1. A substance or method shall be considered for inclusion on the Prohibited List if WADA determines that the substance or method meets any two of the following three criteria: 4.3.1.1. Medical or other scientific evidence, pharmacological effect or experience that the substance or method has the potential to enhance or enhances sport performance; 4.3.1.2. Medical or other scientific evidence, pharmacological effect or experience that the use of the substance or method represents an actual or potential health risk to the athlete; 4.3.1.3. WADA's determination that the use of the substance or method violates the spirit of sport described in the Introduction of the Code

17 Substance Classification Booklet – 2004 2004 WADA Prohibited List

4.3.2. A substance or method shall also be included on the Prohibited List if WADA determines there is medical or other scientific evidence, pharmacological effect or experience that the substance or method has the potential to mask the use of other Prohibited Substances and Prohibited Methods.

4.3.3. WADA's determination of the Prohibited Substances and Prohibited Methods that will be included on the Prohibited List shall be final and shall not be subject to challenge by an athlete or other person based on an argument that the substance or method was not a masking agent or did not have the potential to enhance performance, represent a health risk, or violate the spirit of sport.” x The following is extracted from the 2004 WADA Prohibited List. It is divided in the following sections: – Substances (S) and Methods (M) Prohibited In-Competition – Substances Prohibited in Particular Sports – Substances (S) and Methods (M) Prohibited In- and Out- of Competition – Specified Substances – The 2004 Monitoring Program.

For specific examples of Prohibited Substances, refer to the Prohibited Substances section.

Although most national sport governing bodies and international sport federations prohibit the use of substances and methods outlined by WADA, it is important to note that some of the Prohibited Substances may vary from sport to sport. It is the athlete’s responsibility to know his or her sport’s anti-doping regulations. In cases of uncertainty, it is recommended to check with the appropriate relevant governing body and/or international sports federations.

Substances (S) and Methods (M) Prohibited In-Competition S1. Stimulants Stimulants, identified by “S1.”, including their optical (D- and L-) isomers and other substances with similar chemical structure or similar pharmacological effects are prohibited.

S2. Narcotics Narcotics, identified by “S2.”, are prohibited.

S3. Cannabinoids Cannabinoids (eg. marijuana, hashish) are prohibited.

S4. Anabolic agents All anabolic agents are prohibited.

18 Substance Classification Booklet – 2004 2004 WADA Prohibited List

1. Anabolic Androgenic Steroids (AAS)

a. Exogenous1 Anabolic Androgenic Steroids Exogenous1 AAS and other substances with similar chemical structure or similar pharmacological effect(s), including but not limited to those identified by “S4.1a”, are prohibited.

b. Endogenous2 Anabolic Androgenic Steroids Endogenous2 AAS and other substances with similar chemical structure or similar pharmacological effect(s), including but not limited to those identified by “S4.1b”, are prohibited.

Where a Prohibited Substance is capable of being produced by the body naturally, a x Sample will be deemed to contain such Prohibited Substance where the concentration of the Prohibited Substance or its metabolites or markers and/or any other relevant ratio(s) in the Athlete’s Sample so deviates from the range of values normally found in humans so as not to be consistent with normal endogenous production. A Sample shall not be deemed to contain a Prohibited Substance in any such case where the Athlete proves by evidence that the concentration of the Prohibited Substance or its metabolites or markers and/or the relevant ratio(s) in the Athlete’s Sample is attributable to a pathological or physiological condition. In all cases, and at any concentration, the laboratory will report an adverse finding if, based on any reliable analytical method, it can show that the Prohibited Substance is of exogenous origin.

If the laboratory result is not conclusive and no concentration as referred to in the above paragraph is found, the CCES shall conduct a further investigation if there are serious indications, such as a comparison to reference steroid profiles, for a possible Use of a Prohibited Substance.

If the laboratory has reported the presence of a T/E ratio greater than six (6) to one (1) in the urine, further investigation is obligatory in order to determine whether the ratio is due to a physiological or pathological condition.

In both cases, the investigation will include a review of any previous tests, subsequent tests and/or results of endocrine investigations. If previous tests are not available, the Athlete shall undergo an endocrine investigation or be tested unannounced at least three times within a three month period.

Failure of the Athlete to co-operate in the investigations will result in considering the Athlete’s Sample to contain a Prohibited Substance.

2. Other Anabolic Agents Other anabolic agents, identified by “S4.2”, are prohibited.

1 Exogenous refers to a substance which is not capable of being produced by the body naturally. 2 Endogenous refers to a substance which is capable of being produced by the body naturally.

19 Substance Classification Booklet – 2004 2004 WADA Prohibited List

S5. Peptide hormones The following substances including other substances with similar chemical structure or similar pharmacological effect(s) and their releasing factors are prohibited.

1. Erythropoietin (or EPO) (identified by “S5.1” ) 2. Growth hormone (hGH) and Insulin-like Growth Factor (IGF-1) (identified by “S5.2”) 3. Chorionic Gonadotrophin (hCG) prohibited in males only (identified by “S5.3”) 4. Pituitary and synthetic gonadotrophins (LH) prohibited in males only (identified by “S5.4”) 5. Insulin (identified by “S5.5) x 6. Corticotrophins (identified by “S5.6”) Unless the Athlete can demonstrate that the concentration was due to a physiological or pathological condition, a Sample will be deemed to contain a Prohibited Substance where the concentration of the Prohibited Substance or its metabolites and/or relevant ratios or markers in the Athlete’s Sample so exceeds the range of values normally found in humans so as not to be consistent with normal endogenous production.

The presence of other substances with similar chemical structure or similar pharmacological effect(s), diagnostic marker(s) or releasing factors of a hormone listed above or of any other finding which indicate(s) that the substance detected is not the naturally present hormone, will be reported as an adverse analytical finding.

S6. Beta-2 Agonists All Beta-2 agonists, including but not limited to those identified by “S6.”, including their D- and L- isomers are prohibited with the exception of formoterol, salbutamol, salmeterol and terbutaline which are permitted by inhalation only for the prevention and/or treatment of asthma and respiratory ailments with prior Abbreviated Therapeutic Use Exemption (TUE).

Despite the granting of a TUE, concentrations of salbutamol in urine greater than 1000 ng/ml will be regarded as an adverse analytical finding unless the athlete proves that the abnormal result was the consequence of the therapeutic use of inhaled salbutamol.

S7. Agents with anti-oestrogenic activity Agents with anti-oestrogenic activity, identified by “S7.”, are prohibited in males only.

S8. Masking Agents Masking agents, including but not limited to those identified by “S8.”, are prohibited due to their potential to impair the excretion of Prohibited Substances, to conceal their presence in urine or other samples used in doping control, or to change haematological parameters.

A TUE is not valid if an athlete’s urine contains a diuretic, including but not limited to

20 Substance Classification Booklet – 2004 2004 WADA Prohibited List those identified by “S8/P3.” and other substances with similar chemical structure or similar pharmacological effects, in association with threshold or sub-threshold levels of a Prohibited Substance(s).

S9. Glucocorticosteroids Glucocorticosteroids, including but not limited to those identified by “S9.”, are prohibited when administered orally, rectally, or by intravenous or intramuscular administration. All other administration routes require prior Abbreviated TUE.

Table 1: Glucocorticosteroid routes of administration and their status in sport

Route of Prohibited Permitted with prior Permitted x Administration Abbreviated TUE (✍) oral (ex. pill form) • rectal (ex. suppository) • intravenous injection • intramuscular injection • local injection • intra-articular injection • inhalation (ex. pump) • topical (ex. cream, • lotion, ointment) anal (ie. around the anus) • aural (ex. ear drop) • nasal (ex. nasal spray) • ophthalmic (ex. eye drops) •

M1. Enhancement of oxygen transfer a. Blood doping. Blood doping is the use of autologous, homologous or heterologous blood or red blood cell products of any origin, other than for legitimate medical treatment.

b. The use of products that enhance the uptake, transport or delivery of oxygen, e.g. erythropoietins, modified haemoglobin products including but not limited to haemoglobin-based blood substitutes, microencapsulated haemoglobin products, perfluorochemicals, and efaproxiral (RSR13).

M2. Pharmacological, chemical, and physical manipulation Pharmacological, chemical and physical manipulation is the use of substances and methods, including masking agents, which alter, attempt to alter or may reasonably be expected to alter the integrity and validity of specimens collected in doping controls.

These include but are not limited to catheterization, urine substitution and/or tampering,

21 Substance Classification Booklet – 2004 2004 WADA Prohibited List

inhibition of renal excretion and alterations of testosterone and epitestosterone concentrations.

M3. Gene doping Gene or cell doping is defined as the non-therapeutic use of genes, genetic elements and/or cells that have the capacity to enhance athletic performance.

Substances Prohibited in Particular Sports P1. Alcohol x Unless otherwise specified, alcohol (ethanol), identified by “P1.” is prohibited in competition only in the following sports. Detection will be conducted by breath analysis and/or blood. The doping violation threshold for each sport federation is reported in parenthesis (if no threshold is indicated, the presence of any quantity of alcohol shall constitute a doping violation).

• Aeronautic (FAI) (0.05 g/L) • Archery (FITA) (0.10 g/L) • Automobile (FIA) • Billiards (WCBS) • Boules (CMSB) (0.50 g/L) • Gymnastics (FIG) (0.10 g/L) • Karate (WKF) (0.40 g/L) • Modern Pentathlon (UIPM) (0.10 g/L) • Motorcycling (FIM) • Roller Sports (FIRS) (0.02 g/L) • Skiing (FIS) • Triathlon (ITU) (0.40 g/L) • Wrestling (FILA)

P2. Beta-Blockers Unless otherwise specified, beta-blockers, including but not limited to those identified by “P2.”, are prohibited in competition only in the following sports:

• Aeronautic (FAI) • Archery (FITA) (also prohibited out of competition) • Automobile (FIA) • Billiards (WCBS) • Bobsleigh (FIBT) • Boules (CMSB) • Bridge (FMB) • Chess (FIDE) • Curling (WCF) • Gymnastics (FIG)

22 Substance Classification Booklet – 2004 2004 WADA Prohibited List

• Modern Pentathlon (UIPM) • Motorcycling (FIM) • Nine-pin Bowling (FIQ) • Sailing (ISAF) (match race helms only) • Shooting (ISSF) (also prohibited out of competition) • Skiing (FIS) (in ski jumping and free style snow board) • Swimming (FINA) (in diving and synchronised swimming) • Wrestling (FILA)

P3. Diuretics Diuretics, including but not limited to those identified by “P3”, are prohibited in all sports as masking agents. However, in the following weight-classified sports and sports x where weight loss can enhance performance, no Therapeutic Use Exemptions shall be granted for use of diuretics.

• Body-Building (IFBB) • Boxing (AIBA) • Judo (IJF) • Karate (WKF) • Powerlifting (IPF) • Rowing (light weight) (FISA) • Skiing (FIS) for ski jumping only • Taekwondo (WTF) • Weightlifting (IWF) • Wrestling (FILA) • Wushu (IWUF)

Substances (S) and Methods (M) Prohibited In and Out of Competition S4. Anabolic Agents S5. Peptide Hormones S6. Beta-2 Agonists (only clenbuterol and salbutamol when its concentration is greater than 1000ng/mL) S7. Agents with Anti-Oestrogenic Activity S8. Masking Agents M1. Enhancement of Oxygen Transfer M2. Pharmacological, Chemical, and Physical Manipulation M3. Gene Doping P2. Beta Blockers in Archery and Shooting

23 Substance Classification Booklet – 2004 2004 WADA Prohibited List

Specified Substances An anti-doping violation involving the following substances may result in a reduced sanction provided that the athlete can establish that the use of such specified substance was not intended to enhance sport performance.

• Stimulants: ephedrine, L-methylamphetamine, methylephedrine • Cannabinoids • Inhaled beta-2 Agonists (except clenbuterol) • Diuretics (this does not apply to section P3) • Glucocorticosteroids • Masking agents: Probenecid x • Beta Blockers • Alcohol

The 2004 Monitoring Program The WADA Code (4.5) states “WADA, in consultation with other Signatories and governments, shall establish a monitoring program regarding substances which are not on the Prohibited List, but which WADA wishes to monitor in order to detect patterns of misuse in sport.”

The following substances are placed on the 2004 Monitoring List:

Stimulants: In-Competition Only: caffeine, phenylephrine, phenylpropanolamine, pipradrol, pseudoephedrine, synephrine.

Narcotics: In-Competition Only: morphine/codeine ratio.

24 Substance Classification Booklet – 2004 Prohibited Substances

Prohibited Substances The following is a non-exhaustive list in alphabetical order of Prohibited Substances. It includes substances that are prohibited in particular sports only and those that require an Abbreviated Therapeutic Use Exemption (refer to the Therapeutic Use Exemption (TUE) section of this Booklet). Please note that this non-exhaustive list does not contain any examples of Prohibited Methods.

Generic medicines are often named by the abbreviation of the company followed by the chemical name of the substance eg: Apo-, Depo-, Gen-, Lin-, Neo-, Novo-, PMS-, Ratio-, Rho-, Rhoxal, Riva-, Solu-, and Taro-. For example, Apo-Salbutamol is salbutamol. x The first letter and number (eg. S3) indicate the class of Prohibited Substances in which the product falls into (categorized in the 2004 WADA Prohibited List section of this Booklet ). Generic names or non-proprietary names are written in plain text and brand names are in bold.

For each brand name the Prohibited Substance is indicated in brackets.

Legend:

✍ - may be permitted with prior Abbreviated TUE - is prohibited in males only † - foreign product

25 Substance Classification Booklet – 2004 Prohibited Substances

Prohibited Substances S4-1a. † 1-testosterone S4-1a. † Anavar (oxandrolone) S4-1b. † 4-androstenedione S4-1b. Andriol (testosterone) S4-1a. † 4-hydroxy-19-nortestosterone S4-1b. Androderm (testosterone) S4-1a. † 4-hydroxytestosterone S4-1b. † Androdiol (androstenediol) S4-1b. † 5AD-androstenediol S4-1b. AndroGel (testosterone) (androstenediol) S4-1a. † Android (methyltestosterone) S4-1b. † 5-androstenedione S4-1a. † Androlone-D (nandrolone) S4-1a. † 19-norandrostenediol S4-1a. Androstadienone S4-1a. † 19-norandrostenedione S4-1b. Androstanolone S8/P3. Accuretic (hydrochlorothiazide) S4-1b. † Androstene, -50, -100 P2. Acebutolol (androstenedione) x S8/P3. Acetazolam S4-1b. Androstenediol S8/P3. Acetazolamide S4-1b. Androstenedione S5.6. ACTH S9. Anodan HC (hydrocortisone) S5.6. Acthar (corticotrophin) S9. Anugesic HC6 (hydrocortisone) S1. Adam S9. Anusol HC6 (hydrocortisone) S1. † Adderall (amphetamine) S8/P3. Apo-Hydro (hydrochlorothiazide) S1. Adrafinil P2. Apo-Labetalol (labetalol) S5.6. Adrenocorticotrophin S8/P3. Apo-Methazide S6/S9. ✍ Advair Diskus/Inhalation (hydrochlorothiazide) Aerosol (salmeterol, fluticasone) P2. Apo-Nadol (nadolol) S6. ✍ Airomir (salbutamol) S5-1. Aranesp (erythropoietin) S6. Albuterol5 S7. Arimidex (anastrozole P1. Alcohol –aromatase inhibitor) S8/P3. Aldactone (spironolactone) S9. Aristocort6 (triamcinolone) S8/P3. Aldactazide -25, -50 S9. Aristospan6 (triamcinolone) (hydochlorothiazide, spironolactone) S7. Aromasin (exemestane S1. Alertec (modafinil) –aromatase inhibitor) S8/P3. -Almizide (amiloride, S7. Aromatase Inhibitors hydrochlorothiazide) S8/P3. Atacand Plus (hydrochlorothiazide) P2. Alprenolol P2. Atenolol S9. Amcinonide6 S8/P3. Avalide (hydrochlorothiazide) S1. Amfepramone S6. Bambuterol S1. Amfetamine S9. ✍ Barriere HC (hydrocortisone) S1. Amfetaminil S9. Beclomethasone6 S1. Amifenazole S8/P3. Bendrofluazide S8/P3. Amiloride S8/P3. Bendroflumethiazide S1. Amiphenazole S8. Benuryl (probenecid) S8/P3. Amipramizide S1. Benzfetamine S1. Amphetamine S8/P3. Benzhydrofluemethiazide S1. Amphetaminil S1. Benzphetamine S4-1a. † Anadur (nandrolone) S6. Berotec Inhalation S7. Anastrozole Aerosol/Solution (fenoterol)

5 Permitted by inhalation with prior Abbreviated TUE. 6 The status of this substance depends on the route of its administration. Refer to the table 1 under S9. Glucocorticosteroids.

26 Substance Classification Booklet – 2004 Prohibited Substances

S9. ✍ Betaderm (betamethasone) (hydrocortisone) P2. Betagan (levobunolol) S4-2. Clenbuterol S9. Betaject6 (betamethasone) S4-1b. Climacteron (testosterone) P2. Betaloc (metoprolol) S1. Clobenzorex S9. Betamethasone6 S9. Clobetasol6 P2. Betaxolol S9. Clobetasone6 S9. ✍ Betnesol (betamethasone) S7. Clomid (clomiphene) P2. Betoptic S (betaxolol) S7. Clomiphene P2. Bisoprolol S4-1a. Clostebol S9. ✍ Blephamide (prednisolone) S1. Cocaine S4-1a. Bolasterone S6. ✍ Combivent Inhalation S4-1a. Boldenone (salbutamol) S4-1a. Boldione S1. Concerta (methylphenidate) x P2. Brevibloc (esmolol) P2. Coreg (carvedilol) S6. ✍ Bricanyl Turbuhaler P2. Corgard (nadolol) (terbutaline) S9. ✍ Cortate (hydrocortisone) S1. Bromantan S9. Cortef6 (hydrocortisone) S9. Budesonide6 S9. Cortenema6 (hydrocortisone) S8/P3. Bumetanide S5.6. Corticotrophin P2. Bunolol S5.6. Corticotropin S2. † Buprenex (buprenorphine) S9. Cortifoam6 (hydrocortisone) S2. Buprenorphine S9. ✍ Cortimyxin (hydrocortisone) S8/P3. Burinex (bumetanide) S9. Cortisone6 S3. Cannabinoids S9. ✍ Cortisporin (hydrocortisone) S8/P3. Canrenone S9. ✍ Cortoderm (hydrocortisone) S1. Carfedon S5.6. Cortrosyn (corticotrophin) S1. Carphedon S8/P3. † Corzide (bendroflumethiazide) P2. Carteolol P2. Cosopt (timolol) P2. Carvedilol S9. ✍ Cyclocort Lotion/Ointment 7 S1. Cathine (amcinonide) S1. † Catovit (prolintane) S7. Cyclofenil S9. ✍ Celestoderm V, V/2 S4-1a. Cyclomen (danazol) (betamethasone) S1. † Cylert (pemoline) S9. Celestone6 Soluspan S1. D-amphetamine (betamethasone) S4-1a. Danazol P2. Celiprolol S4-1a. † Danocrine (danazol) S8/P3. Chlorothiazide S9. Decadron (dexamethasone) S1. Chlorpropylamphetamine S4-1a. Deca-Durabolin (nandrolone) S8/P3. Chlortalidone S4-1a. Dehydrochloromethyltestosterone S4-1a. Chlortestosterone S4-1b. Dehydroepiandrostene S4/SD. Chlorthalidone S4-1b. Delatestryl (testosterone) S5-3. Chorionic Gonadotrophin (hCG) S4-1a. Delta1-androstene-3,17-dione S9. ✍ Cipro HC (hydrocortisone) S4-1a. Delta1-dihydro-testosterone S9. ✍ Claritin Skin Itch Relief S2. Demerol (pethidine)

6 The status of this substance depends on the route of its administration. Refer to the table 1 under S9. Glucocorticosteroids. 7 For cathine, the definition of a positive test result is a concentration in urine greater than 5 micrograms per millitre.

27 Substance Classification Booklet – 2004 Prohibited Substances

S1. Deprenyl S4-1a. Dromostanolone S9. ✍ Derma-Smoothe/FS S4-1a. Drostanediol (fluocinolone acetonide) S4-1a. Drostanolone S9. ✍ Dermasone (clobetasol) S4-1b. † Duogex (testosterone) S9. ✍ Dermatop (prednicarbate) S6. Duovent UDV (fenoterol) S4-1a. Dermonal vetenary S4-1a. † Durabolin (nandrolone) (methyltestosterone) S1. Ecstasy S9. ✍ Dermovate Cream/Ointment S8/P3. Edecrin (etacrynic acid) 6 (clobetasol) S9. Egozinc HC (hydrocortisone) 8 S9. ✍ Desocort Cream/Ointment S1. Eldepryl (ephedrine ) S9. ✍ Elocom (mometasone) (desonide) ✍ S9. Desonide6 S9. Emo-Cort (hydrocortisone) x S9. Desoximetasone6 S2. Endocet (oxycodone) S1. Desoxyephedrine S2. Endodan (oxycodone) S1. Desoxynorephedrine S9. Entocort capsules/Enema S9. Dexamethasone6 (budesonide) 8 S1. Dexamphetamine S1. Ephedrine 8 S9. Dexasone (dexamethasone) S1. Ephedrine HCL (ephedrine ) 8 S1. Dexedrine (amphetamine) S1. Ephedrine Sulfate (ephedrine ) S8. Dextran S1. Ephedrine Sulfate Injection 8 S1. Dextroamphetamine (ephedrine ) S2. Dextromoramide S8. Epitestosterone S4-1b. DHEA S5-1. EPO S4-1b. DHT S5-1. Eprex (erythropoietin) S2. Diagesil (diamorphine) S4-1a. Equipoise vetenary (boldenone) S2. Diamorphine S5-1. Erythropoietin (EPO) S8/P3. Diamox (acetazolam) P2. Esmolol S1. Diethylproprion S8/P3. Etacrynic acid S9. Diflucortolone6 S1. Etamphetamine S8/P3. Dihydrochlorothiazide S1. Etilamphetamine S1. Dihydromorphinone S1. Etilefrine S1. Dihydrone P1. Ethanol S4-1b. Dihydrotestosterone S1. Ethylamphetamine S2. Dilaudid, -HP, -XP S4-1a. Ethylnorgestrienone (hydromorphone) S7. Exemestane S1. Dimetamphetamine S7. Femara (letrozole -- aromatase S1. Dimethylamphetamine inhibitors) S4-1a. † Dimetriose (gestrinone) S1. Fencamfamine S4-1b. † Diol-4 (androstenediol) S1. Fenetylline S9. ✍ Diprolene (betamethasone) S1. Fenfluramine S9. ✍ Diprosalic (betamethasone) S6. Fenoterol S9. ✍ Diprosone (betamethasone) S1. Fenproporex S2. † Dolophine (methadone) S1. Fensidnimine S9. ✍ Dovobet (betamethasone) S7. † Fertodur (cyclofenil)

28 Substance Classification Booklet – 2004 Prohibited Substances

S9. ✍ Flarex (fluorometholone) S5-5. Humalog (insulin) S9. ✍ Flonase (fluticasone) S5-3. Human Chorionic Gonadotrophin S9. Florinef (fludrocortisone) S5-2. Humatrope (somatropin --growth S9. ✍ Flovent (fluticasone) hormone) S9. ✍ Flovent HFA (fluticasone) S5-5. Humulin (insulin) S9. Fludrocortisone6 S9. Hycort (hydrocortisone) S9. Flumethasone6 S9. ✍ Hyderm (hydrocortisone) S9. Flunisolide6 S8/P3. Hydrochlorothiazide S9. ✍ Fluoderm Cream/Ointment S9. Hydrocortisone6 (fluocinolone) S2. Hydromorph, -Contin S9. Fluocinolone6 (hydromorphone) S9. Fluocinonide6 S2. Hydromorphone S9. Fluorometholone6 S2. Hydromorphone HP x S4-1a. Fluoxymesterone S9. ✍ HydroVal (hydrocortisone) S9. Fluticasone6 S8. Hydroxyethyl starch S9. ✍ FML (fluorometholone) S8/P3. Hyzaar, -DS (hydrochlorothiazide) S6. ✍ Foradil (formoterol) S5-2. IGF-1 S4-1a. Formebolone S8/P3. Indapamide ✍ S6. Formoterol5 S9. Inflamase Forte (prednisolone) S2. Formyldienolone S8/P3. Inhibace Plus S8/P3. Frusemide (hydrochlorothiazide) S9. ✍ Fucidin H (hydrocortisone) S5-5. Innovo (insulin) S1. Furfenorex S5-5. Insulin S8/P3. Furosemide S5-2. Insulin-like Growth Factor (IGF-1) S9. ✍ Garasone (betamethasone) S1. Ionamin (phentermine) S2. Isonipecaine S9. ✍ Gen-Beclo AQ (beclomethasone) S1. Isoproterenol HCl for Injection S8. Gentran (dextran –plasma USP (isoproterenol) expander) S2. Kadian (morphine9) S4-1a. Geri-Tabs vetenary S9. ✍ Kenacomb (triamcinolone) (methyltestosterone) S9. Kenalog6 (triamcinolone) S4-1a. Gestrinone S8/P3. Lasix, -Special (furosemide) S5-2. Growth hormone (hGH) P2. Labetalol S9. Halcinonide6 P2. Labetalol HCl Injection USP S9. Halobetasol6 (labetalol) S9. ✍ Halog Cream/Ointment S1. Levmethamphetamine (halcinonide) P2. Levobunolol S3. Hashish (cannabinoids) S7. Letrozole S5-3. hCG S5-4. LH S9. Hemcort HC6 (hydrocortisone) ✍ S8. Hetastarch S9. Lidemol (fluocinonide) S2. Heroin S9. ✍ Lidex (fluocinonide) S8. HES (hydroxylethyl starch) P2. Linsotalol (sotalol) S5-2. hGH S9. ✍ Locacorten Vioform

5 Permitted by inhalation with prior Abbreviated TUE. 6 The status of this substance depends on the route of its administration. Refer to the table 1 under S9. Glucocorticosteroids. 9 For morphine, the definition of a positive test result is a concentration in urine greater than 1 microgram per millitre of urine.

29 Substance Classification Booklet – 2004 Prohibited Substances

Cream/Eardrops (flumethasone) S4-1a. Methandriol P2. Lopresor (metoprolol) S4-1a. Methandrostenolone S9. ✍ Lotriderm (betamethasone) S4-1a. Methylandrostenediol S1. Love Drug S4-1a. Methyltestosterone S1. Love Pill P2. Metipranolol S8/P3. Lozide (indapamide) P2. Metoprolol S5-4. Lutropin S4-1a. Mibolerone S9. ✍ Lyderm Cream/Ointment S8/P3. Midamor (amiloride) (fluocinonide) S1. Modafinil S4-1b. Malogen (testosterone) S8/P3. Moduret (amiloride, S4-1b. Malogex (testosterone) hydrochlorothiazide) 6 S1. Malt Plus (strychnine) S9. Mometasone x S3. Marijuana (cannabinoids) P2. Monocor (bisoprolol) 9 S9. ✍ Maxidex (dexamethasone) S2. Morphine 9 S9. ✍ Maxitrol (dexamethasone) S2. M.O.S., -SR (morphine ) P2. Monitan (acebutolol) S1. MDA S2. MS, -Contin, •IR (morphine9) S1. MDMA P2. Nadolol S9. Medrol6 (methylprednisolone) S4-1a. Nandrolone S1. Mefenorex S9. ✍ Nasacort (triamcinolone) S1. Mellow Drug of America ✍ S2. Meperidine S9. Nasonex (mometasone) S1. Mephentermine S8/P3. † Naturetin (bendroflumethiazide) S1. Mephetedrine S4-1a. † Nemestran (gestrinone) S8/P3. Mersalyl S4-1b. Neo pause (testosterone) S1. Mesocarb S9. ✍ Nerisalic (diflucortolone) S4-1a. Mestanolone S1. Nicethamide S4-1a. Mesterolone S1. Nikethamide S4-1a. Metandren (methyltestosterone) S4-1a. † Nilevar (norethandrolone) S1. Methamphetamine S4-1a. Norbolethone S1. Methylamphetamine S4-1a. Norethandrolone S1. Methylenedioxyamphetamine S1. Norfenfluramine S1. Methylenedioxymethamphetamine S7. Novaldex, -D (tamoxifen) S1. Methylephedrine10 S8/P3. Novamilor (amiloride, S1. Methylphenidate hydrochlorothiazide) S9. Methylprednisolone6 S5-5. Novolin (insulin) S1. Madam Pearl’s Cough Syrup S6. Novo-Salmol Tablets (salbutamol) (ephedrine8) S8/P3. Novo-Spiroton (spironolactone) S2. Metadol (methadone) S8/P3. Novo-Spirozine S4-1a. Metandienone (hydrochlorothiazide, S4-1a. Metenolone spironolactone) S2. Methadone S8/P3. Novo-Triamzide S4-1a. Methenolone (hydrochlorothiazide, triamterene) S4-1a. Methandienone P2. Nu-Metop (metoprolol)

6 The status of this substance depends on the route of its administration. Refer to the table 1 under S9. Glucocorticosteroids. 8 For ephedrine, the definition of a positive test result is a concentration in urine greater than 10 micrograms per millitre of urine. 9 For morphine, the definition of a positive test result is a concentration in urine greater than 1 microgram per millitre of urine. 10 For methylephedrine, the definition of a positive test result is a concentration in urine greater than 10 micrograms per millitre of urine.

30 Substance Classification Booklet – 2004 Prohibited Substances

S2. Numorphan (oxymorphone) S2. PMS-Oxycodone-Acetaminophen S5-2. Nutropin (somatropin --growth (oxycodone) hormone) S9. ✍ Pramox HC (hydrocortisone) S1. † Olmifon (adrafinil) S9. Prednicarbate6 S1. Omni-Tuss (ephedrine8) S9. ✍ Pred Forte/Mild (prednisolone) S9. ✍ Oracort (triamcinolone) S9. Prednisolone6 S4-1a. † Oranabol (oxymesterone) S9. Prednisone S4-1a. Oxabolone S1. † Prefamone (amfepramone) S4-1a. † Oxandrin (oxandrolone) S5-3. Pregnyl (human Chorionic S4-1a. Oxandrolone Gonadotrophin) S1. Oxazimedrine S9. ✍ Prevex (betamethasone) S6. ✍ Oxeze (formoterol) S9. ✍ Prevex HC (hydrocortisone) P2. Oxprenolol x S1. † Primobolan (metenolone) S2. Oxycodone S8/P3. Prinzide (hydrochlorothiazide) S2. Oxycone S8. Probenecid S2. OxyContin (oxycodone) P2. Probeta (levobunolol) S2. Oxy •IR (oxycodone) S9. Proctodan6 (hydrocortisone) S4-1a. Oxymesterone S9. Proctofoam6 (hydrocortisone) S4-1a. Oxymetholone S9. Proctomyxin6 (hydrocortisone) S2. Oxymorphone S9. Proctosedyl6 (hydrocortisone) S2. † Palfium (dextromoramide) S5-3. Profasi (human Chorionic S4-1a. † Parabolan (trenbolone) Gonadotrophin) S1. Parahydroxyamphetamine S1. Prolintane S9. Pediapred (prednisolone) S1. † Promotil (prolintane) S1. Pemoline S9. ✍ Propaderm (beclomethasone) S9. ✍ Pentamycetin (hydrocortisone) P2. Propanolol S8. Pentaspan (pentastarch –plasma S5-2. Protropin (somatrem --growth expander) hormone) S8. Pentastarch S1. † Provigil (modafinil) S2. Pentazocine S4-1a. † Proviron (mesterolone) S2. Percocet, -Demi (oxycodone) S9. ✍ Pulmicort S2. Percodan, -Demi (oxycodone) Nebuamp/Turbuhaler S2. Pethidine (budesonide) S1. Phendimetrazine S4-1a. Quinbolone S1. Phenimethoxazine S9. ✍ Qvar (beclomethasone) S1. Phenmetrazine ✍ S1. Phenoxazole S9. Ratio-Clobetasol (clobetasol) S1. Phentermine S9. ✍ Ratio-Ectosone S1. Phenylisohydantin (betamethasone) P2. -Pindol (pindolol) P2. Ratio-Levobunolol (levobunolol) P2. Pindolol S1. Ratio-Methylphenidate S5-4. Pituitary gonadotrophins (LH) (methylphenidate) S8. Plasma expanders (eg. S2. Ratio-Morphine (morphine) hydroxyethyl starch) S2. Ratio-Oxycocet (oxycodone)

31 Substance Classification Booklet – 2004 Prohibited Substances

S2. Ratio-Oxycodan (oxycodone) S8/P3. Supres (chlorothiazide) S9. Ratio-Proctosone6 (hydrocortisone) S1. Sydnocarb S9. ✍ Ratio-Triacomb (triamcinolone) S6/S9. ✍ Symbicort Turbuhaler S9. ✍ Ratio-Topilene (betamethasone) (formoterol, budesonide) S9. ✍ Ratio-Topisone (betamethasone) S5.6. Synacthen Depot (corticotrophin) S9. Rectoderm6 (hydrocortisone) S9. ✍ Synalar (fluocinolone) S9. Rectogel6 (hydrocortisone) S5-4. Synthetic gonadotrophins (LH) S6. Reproterol S2. Talwin (pentazocine) S9. ✍ Rhinocort (budesonide) S7. Tamofen (tamoxifen) P2. Rhotral (acebutolol) S7. Tamoxifen S9. Rimexolone6 S9. ✍ Taro-Sone (betamethasone) S1. Ritalin, -SR (methylphenidate) S2. † Temgesic (buprenorphine) x S2. Rivacocet (oxycodone) S1. Tenamfetamine S9. ✍ Rivanase AQ (beclomethasone) P2/S8/P3. Tenoretic (atenolol,chlortalidone) S9. Sab-Anuzinc HC, Plus S1. Tenuate (amfepramone) (hydrocortisone) S6. Terbutaline5 S9. ✍ Sab-Pentasone S4-1b. Testosterone (betamethasone) S4-1b. † Testoviron (testosterone) S5-2. Saizen (somatropin --growth S4-1b. † Tetrabol (androstenedione) hormone) S5.6. Tetracosactide S6. Salbutamol5 S4-1a. Tetrahydrogestinone S6. Salmeterol5 S4-1a. † Theranabol (oxymesterone) S9. ✍ Sarna HC (hydrocortisone) S4-1a. THG P2. Sectral (acebutolol) S8/P3. Thiazides S1. Selegiline S9. ✍ Tiamol (fluocinonide) S6. ✍ Serevent (salmeterol) P2. -Timol (timolol) S7. Serophene (clomiphene) P2. Timolol S5-2. Serostim (somatropin --growth P2. Timoptic, -XE (timolol) hormone) P2. Timpilo (timolol) S9. ✍ Sofracort (dexamethasone) S9. ✍ Tobradex (dexamethasone) S9. Solu-Cortef (hydrocortisone) S9. ✍ Topicort Cream/Gel/Ointment S5-2. Somatrem (desoximetasone) S5-2. Somatropin S9. ✍ Topsyn Gel (fluocinonide) P2. Sotacor (sotalol) P2. Trandate (labetalol) P2. Sotalol P2. Trasicor (oxprenolol) S8/P3. Spironolactone S4-1a. Trenbolone S4-1a. Stanozolol S9. ✍ Triaderm (triamcinolone) S2. Statex (morphine9) S9. Triamcinolone6 S4-1a. Stenbolone S8/P3. Triamterene S4-1a. † Stromba (stanozolol) S8/P3. -Triazide (hydrochlorothiazide, S1. Strychnine triamterene) S2. Supeudol (oxycodone) S4-1a. † Trofodermin (clostebol)

5 Permitted by inhalation with prior Abbreviated TUE. (Salbutamol is prohibited as an anabolic agent when the concentration in urine is greater than 1000ng/ml despite prior granting of TUE) 6 The status of this substance depends on the route of its administration. Refer to the table 1 under S9. Glucocorticosteroids. 9 For morphine, the definition of a positive test result is a concentration in urine greater than 1 microgram per millitre of urine.

32 Substance Classification Booklet – 2004 Prohibited Substances

S6. Tulobuterol S9. ✍ Viaderm KC (triamcinolone) S4-1a. Turinabol S9. ✍ Vioform Hydrocortisone S9. ✍ Ultravate (halobetasol) (hydrocortisone) S4-1b. Uni-bol vetenary (testosterone) S4-1b. † Virilon (testosterone) S4-1b. Uni-test vetenary (testosterone) S8/P3/P2. Viskazide (hydrochlorothiazide, S9. ✍ Uremol (hydrocortisone) pindolol) S9. ✍ Valisone (betamethasone) P2. Visken (pindolol) S8/P3. Vaseretic (hydrochlorothiazide) S1. † Volital (pemoline) S9. ✍ Vasocidin (prednisolone) S9. ✍ Westcort (hydrocortisone) S4-2. Ventipulmin vetenary (clenbuterol) S9. Winpred (prednisone) S6. ✍ Ventodisk (salbutamol) S4-1a. Winstrol (stanozolol) S6. ✍ Ventolin (salbutamol) S1. † Wyamine (mephentermine) S1. XTC x S6. ✍ Ventolin Diskus (salbutamol) S6. ✍ Ventolin HFA (salbutamol) S4.2. Zeranol S8/P3. Zestoretic (hydrochlorothiazide) S6. Ventolin Injection (salbutamol) S6. ✍ Ventolin Nebules P.F. (salbutamol) S6. Ventolin Oral Liquid (salbutamol) S6. ✍ Ventolin Respirator Solution (salbutamol) S9. ✍ Vexol (rimexolone)

Substance Classification Booklet – 2004 Therapeutic Use Exemption (TUE)

Therapeutic Use Exemption A Therapeutic Use Exemption (TUE) may be granted by the CCES to an athlete permitting the use of a Prohibited Substance or Prohibited Method contained on the Prohibited List.

An exemption will only be considered by the CCES for a medically justified reason and under the following circumstances: • the athlete would experience a significant impairment to health if the Prohibited Substance or Prohibited Method were to be withheld in the course of treating an acute or chronic medical condition; • the use of the Prohibited Substance or Prohibited Method would produce no additional enhancement of performance other than that which might be anticipated by a return to a state of normal health following the treatment of a legitimate medical condition and; • there is no reasonable therapeutic alternative or any alternative is inefficient.

For example, when the above-mentioned conditions have been demonstrated, a TUE may be granted to an athlete for: • the use of insulin for the treatment of insulin-dependent diabetes; TUE • the use of a salbutamol inhaler for the treatment of asthma; • the use of a hydrocortisone cream for the treatment of eczema.

A TUE typically would not be granted for: • the use of a nutritional supplement or vitamin; • the recreational use of cannabinoids.

The CCES TUE processes are subject to change once the CCES implements the new Code-compliant Canadian Anti-Doping Program in the summer of 2004. Details will be provided on the CCES website.

Where does an athlete have to apply for a TUE? At this time, all Canadian athletes must contact the CCES to apply for a TUE. Canadian athletes that compete at an international level may also be required to submit their TUE application to their international sport federation. These athletes are advised to contact their international sport federation to determine if this is necessary.

As the World Anti-Doping Code is accepted globally, its goal of harmonizing and coordinating anti-doping programs at the international and national level will only require athletes to submit their TUE applications to one organization.

When should an athlete apply for a TUE? Applications should be made at the time the prohibited medication(s) is/are recommended to the athlete by the athlete’s physician. In the event that the athlete is in

35 Substance Classification Booklet – 2004 Therapeutic Use Exemption (TUE)

his/her competitive season, he/she must submit his/her application prior to participating in an event11.

An athlete should not begin to use a Prohibited Substance before being granted a TUE by the CCES.

How can an athlete apply for a TUE? There are two kinds of TUEs: Abbreviated and Standard TUEs.

1. Abbreviated TUE It is acknowledged that some substances included on the Prohibited List are used to treat medical conditions frequently encountered in the athlete population. As such, the following substances are subject to the Abbreviated TUE process: • ßeta-2 Agonists by inhalation only (formoterol, salbutamol, salmeterol, and terbutaline) • Glucocorticosteroids administered by non-systemic routes such as dermatological (skin creams), ophthalmic (eye drops), aural (ear drops), anal (cream applied around the anus), nasal (sprays), intra-articular and local injections, and by inhalation.

Athletes who require the use of these substances must submit a complete Abbreviated

TUE TUE Form to the CCES. The CCES Abbreviated Therapeutic Use Exemption Form (sample shown on page 38) is available on the CCES website (www.cces.ca).

The CCES will only grant approval for use of Prohibited Substances subject to the Abbreviated TUE process once it has received a completed CCES Abbreviated Therapeutic Use Exemption Form. Incomplete forms will be returned to applicants.

Abbreviated TUEs granted by the CCES are valid for the duration of the treatment as prescribed by the athlete’s physician up to a maximum of one year. It is the athlete’s responsibility to know when his/her TUE expires and to apply for renewal, if necessary, before this date.

2. Standard TUE An athlete who requires the use of a Prohibited Substance that is not subject to the Abbreviated TUE process and/or a Prohibited Method must apply for a Standard TUE.

For a Standard TUE application to be considered, the athlete must submit a Standard Therapeutic Use Exemption Form (available upon request to the CCES) as well as all relevant documents that confirm the athlete’s physician’s diagnosis to the CCES. All relevant documentation would include the following: comprehensive medical history, examinations, laboratory investigations, imaging studies, and copies of original reports and/or letters.

11The WADA Standard for Granting TUEs specifies that applications for TUEs should be submitted no less than 21 days before participating in an event.

36 Substance Classification Booklet – 2004 Therapeutic Use Exemption (TUE)

All TUE applications to the CCES are reviewed by a panel of at least three physicians with experience in treating athletes and knowledge of clinical, sports and exercise medicine. Decisions will be conveyed to the athlete by the CCES.

Athletes are advised to retain copies of their submitted TUE applications in the event of an adverse analytical result.

For further information on the TUE process, contact the CCES. TUE

37 SAMPLE ONLY – DOWNLOAD AT

www.cces.ca Substance Classification Booklet – 2004 Supplements

Supplements The term “supplement” includes a wide variety of non-pharmaceutical products such as vitamins, nutritional products, protein powders, ergogenic aids, homeopathic preparations, traditional medicines, amino acids, botanicals and extracts, essential fatty acids, probiotics and minerals or synthetic duplicates of any of these products.

Unlike medications and pharmaceuticals, the regulation of the manufacturing of supplements in Canada and elsewhere is limited. Supplements can, and often do contain Prohibited Substances. Research has demonstrated that as many as one in six products are tainted with Prohibited Substances that were not indicated on the product label. Because the content of many supplements is uncertain, it is very difficult for athletes to distinguish clean, safe, and reliable products from those products which may contain Prohibited Substances.

Under the existing regulatory environment, there is no way to accurately identify all of the constituents of every ingredient found in supplement preparations. Consequently there is no way to guarantee the safety and purity of these products. Until this environment changes, it is not possible for the CCES to guarantee that all the ingredients in a supplement have been listed on the packaging, nor that the composition is the same from batch to batch. This situation highlights the need for athletes to use extreme caution when considering the use of supplement products. (A contemporary review of the issue is available on the CCES website - http://www.cces.ca/pdfs/CCES-PAPER- SupplementsAndSport-E.pdf)

As the CCES has already indicated in several advisory notes (available at www.cces.ca – click on [News], [Advisory Notes]) supplements can contain Prohibited Substances and consumption of these products may result in an adverse analytical finding and an anti- doping rule violation. Athletes are ultimately responsible for all substances they ingest and face the consequences of a strict liability policy in the event of any anti- doping rule violation. e

CCES discourages the use of supplements, from both a scientific and an ethical point of view. Evidence-based research has not demonstrated clearly that dietary supplementation leads to enhanced athletic performance. Moreover, supplements may contain Prohibited Substances that provide athletes with an unfair advantage over their competitors and may cause adverse analytical findings. Because of these issues, the CCES cannot encourage supplement use and does not support supplement product endorsement by sport organisations.

Regardless of the CCES position on supplements, athletes continue to utilize these products. Therefore, we are making efforts to provide Canadian athletes with practical information to help them minimise the risks associated with some of these products. The CCES is currently working with Canadian regulatory authorities, sporting organisations and the supplement manufacturing industry to develop solutions that will provide athletes with more practical and reliable information on safety and efficacy of supplement products. In 2004, CCES and WADA will collaborate on the hosting of the first

39 Substance Classification Booklet – 2004 Supplements

international symposium on supplements in sport to explore this area further.

Managing the Risk There are no fail-safe methods or criteria for reliably identifying “good-quality” products. If you choose to use supplements you may reduce your risk of inadvertently consuming a Prohibited Substance if you:

• Choose a company with a strong history of ethical practices and a solid reputation for producing high-quality products. Care is needed to differentiate between strong marketing strategies and a solid reputation for producing high-quality products. • Consider what other products are made by the company and whether there is potential for contamination or adulteration. • Compare ingredient doses carefully and be sure to read the fine print. Choose products that clearly specify the full plant name, the plant part used, the weight, the concentration and the equivalent amount of raw herb that the dosage unit provides. However, what is printed on the label provides no guarantee of what is in the bottle. • Consider, choosing products from companies that also produce pharmaceuticals, since they generally have high corporate standards for quality. However, this does not guarantee that the product is free from Prohibited Substances. For herbals and botanical products, a thorough understanding of the unique quality problems is also required. • Ask retailers what procedures, if any, are employed to ensure that products on their shelves are of high quality. • Consider seeking a written guarantee for support and compensation from the manufacturer in case the supplements are implicated in adverse analytical findings. Some manufacturers have begun to provide such guarantees. • Look for a telephone number or address to contact the manufacturer in order to obtain information or assurances about the product and quality control procedures, especially in relation to anti-doping rules. e • Check with the CCES or other relevant authority – while it may not have any information about many supplement products, it may have previous experience with a particular product, and may help identify Prohibited Substances that are listed as ingredients. • Many supplement products contain botanical or so-called “natural” sources of ephedrine. Ephedrine is an amphetamine-like stimulant that is banned in sport and can have potentially dangerous effects on the central nervous system and heart. Avoid all products listing ma huang, ma huang extract, ephedra, ephedra sinica, ephedra extract, ephedra herb powder, chinese ephedra, sida cordifolia, epitonin or ephedrine as ingredients.

Athletes must always remember that the ultimate responsibility for what they consume rests with them. If unsure of what you may be consuming, do not take that particular product.

40 NOTES NOTES