Neural processing of facial expressions as modulators of communicative intention Facial expression in communicative intention Rasgado-Toledo Jalil1, Valles-Capetillo Elizabeth1, Giudicessi Averi2, Giordano Magda1*. 1Departament of Behavioral and Cognitive Neurobiology, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Blvd. Juriquilla 3001, Juriquilla, Querétaro, 76230 México 2 Department of Psychiatry, University of California, San Diego 9500 Gilman Drive La Jolla, CA * Corresponding author: E-mail address:
[email protected] (Giordano, Magda) Number of pages: 31 Number of figures: 8 Number of tables: 1 Number of words: Abstract: 250 Introduction: 621 Discussion: 1499 Conflict of Interest The authors declare no competing financial interests Acknowledgments We thank Drs. Erick Pasaye, Leopoldo González-Santos, Juan Ortiz, and the personnel at the National Laboratory for Magnetic Resonance Imaging (LANIREM UNAM), for their valuable assistance. This work received support from Luis Aguilar, Alejandro De León, Carlos Flores, and Jair García of the Laboratorio Nacional de Visualización Científica Avanzada (LAVIS). Additional thanks to Azalea Reyes-Aguilar for the valuable feedback for the entire study process. Significance Statement In the present study, we tested whether previous observation of a facial expression associated with an emotion can modify the interpretation of a speech act that follows a facial expression; thus providing empirical evidence that facial expression impacts communication. Our results could help to understand how we communicate and the aspects of communication that are necessary to comprehend pragmatic forms of language as speech acts. We applied both multivariate and univariate analysis models to compare brain structures involved in speech acts comprehension, and found that the pattern of hemodynamic response of the frontal gyrus and medial prefrontal cortex can be used to decode classification decisions.