INDEX

Volume 172, March-April 1970

Acetazolamide, influence on anion secretion into adrenergic, in rabbit aortic strips, interactions cerebrospinal fluid, 197 between potentiating agents of, 320 Acetylcholine(s) retention in rat heart, effect of bretylium on, 282 effect on adrenal catecholamine secretion, 69 syrnpathomimetic, mephentermine and, evalua- halogeno-, cholinergic activities of, 351 tion of vasodilation produced by, 297 nicotine and, comparison of effects on cycle Amino acids, y-aminobutyric acid and, actions on length and action potentials of guinea-pig mammalian autonomic ganglia, 384 atria, 255 ‘y-Aminobutyric acid, related amino acids and, Acetylsalicylic acid, combination with other actions on mammalian autonomic ganglia, 384 drugs, effects on inflammation induced by 7-Amino g-hydroxybutyric acid, effects on main- carrageenan, 423 malian autonoinic ganglia, 384 Acidosis, effects on chronotropic responses, nor- 3-Amino-1-propanesulfonic acid, effects on mam- epinephrine storage and release in isolated malian autonomic ganglia, 384 guinea-pig atria, 289 Amitriptyline, inhibition of metabolism of gua- Adipose tissue, of cattle, sheep, goats and swine, nethidine and related agents by hepatic mi- concentrations of thiopental in, 128 crosomes by, 108 Adrenalectomy, influence on nicotine-induced in- Amphetamine hibition of contractile activity in stomach effect on heart force in dogs, 297 and duodenum of dog, 377 retention in rat heart after bretylium, 282 Adrenal glands d-Amphetamine, potentiation of jumping activity effects of splanchnic nerve stimulation and induced by sodium 5-(1 ,3-dimethylbutyl)-5- cholinergic agents on secretion of catechola- ethyl barbiturate, 170 mines by, 69 Anesthesia release of catecholamines in response to nico- produced by thiopental in cattle, sheep, goats tine, 377 and swine, 128 Adrenergic amines, in rabbit aortic strips, inter- spinal, influence on nicotine-induced inhibition actions between potentiating agents of, 320 of contractile activity in stomach and duo- Adrenergic blockade denum of dog, 377 alpha and beta, and inotropic response to phen- Anesthetics ylephrine, 274 local, effects of pH gradients on action of pro- beta, of chronotropic effects of nicotine and caine and lidocaine in intact and desheathed norepinephrine in guinea-pig atria, 255 sciatic nerves, 1 effect of phentolamine on responses of normal, local, effects of pH gradients on uptake and dis- denervated and decentralized cat nictitating tribution of C’4-procaine and lidocaine in membrane to methoxamine and norepineph- intact and desheathed sciatic nerve trunks, 18 rine, 91 Anoxia, effect on release of norepinephrine from Adrenergic blocking drugs, beta, reduction of spleen, 342 jumping activity induced by sodium 5-(1,3- Antihistaminee, lack of influence on mephenter- dimethylbutyl)-5-ethyl barbiturate, 170 mine-induced vasodilation in dogs, 297 Adrenergic nerves, release of norepinephrine from Antimalarial drugs, chloroquine diphosphate and isolated rat iris by field stimulation, 332 RP-12278, neuromuscular blocking properties Adrenergic neurons, blockade by guanethidine of, 44 and related agents and antagonism by drugs, Aortic smooth muscle, comparison of retentions of 100 methoxamine and norepinephrine in, 91 AHR-0602, inhibition of contractile activity in Aortic strips stomach and duodenum of dog, 377 rabbit, antagonism of phentolamine against -Alanine, effects on mammalian autonomic gan. glia, 384 exogenously administered and endogenously Alpha adrenergic blockade, lack of effect on mo- released norepinephrine in, 310 tropic action of phenylephrine on rabbit atria, rabbit, interactions between potentiating agents 274 of adrenergic amines in, 320 Amine(s) Artery, pulmonary, main, isolated, rabbit, release

427 428 DmEx

of H2-norepinephrine in relation to muscle tive inhibition by norepinephrine, guanethi- contraction in, 62 dine, debrisoquin, bretylium, tyramine, me- Askari, A. and Rae, S. N. : Drugs affecting sodium taraminob and desipramine, 100 transport in human erythrocyte ghosts, 211 Bevan, J. A., see Su, C., 62 Aspirin, combination with other drugs, effects on Bianchi, C. P. inflammation induced by carrageenan, 423 see Strobel, G. E., 1, 18 Atria see Suarez-Kurtz, G., 33 guinea-pig and cat, rate and contractile force, Bigger, J. T., Jr. and Mandel, W. J. : Effect of effect of gallamine on, 266 lidocaine on conduction in canine Purkinje guinea-pig, electrically driven, biphasic effect fibers and at the ventricular muscle-Purkinje of nicotine on action potential repolarization fiber junction, 239

in, 255 Bis [(chloro-7’ ‘-quinolyl-4”)amino-2’-propylj-1 , 4- guinea-pig, isolated, effects of acidosis on chro- piperazine (RP-12278), antimalarial agent, notropic responses, norepinephrine storage neuromuscular blocking properties of, 44 and release in, 289 Bladder, toad, effect of bendroflumethiazide on rabbit, blockade of inotropic action of phenyl- sodium transport and metabolism in, 203 ephrine by bretylium or cocaine in, 274 Blockade Atropine adrenergic, effect of phentolamine on responses and responses of denervated cat nictitating of normal, denervated and decentralized cat

membrane , 77 nictitating membrane to methoxamine and blockade of effects of acetylcholine and nicotine norepinephrine, 91 in guinea-pig atria, 255 selective, of adrenergic neurons by guanethi- failure to inhibit positive inotropic response to dine and related agents, antagonism by drugs, gallamine, 266 100 lack of influence on mephentermine-induced Blood flow, effects of mephentermine and certain vasodilation in dogs, 297 other sympathomimetic amines on femoral, Autonomic ganglia, mammalian, actions of -y-ami- renal and superior mesenteric arteries in dogs, nobutyric acid and related amino acids on, 384 297 Azzaro, A. J., see Peach, M. J., 289 Boerth, R. C., Ryan, M. J. and Brody, M. J.: Pharmacologic blockade of reflex vasodilata- Barbiturate(s) tion : Effects on postulated neurohumoral in rhesus monkeys, development of tolerance to mechanisms, 52 and physical dependence on, 163 Brain sodium 5-(1 ,3-dimethylbutyl)-5-ethyl, jumping catecholamines synthesized from circulating activity induced by, role of sympathetic H’-tyrosine, daily rhythm in accumulation nervous system, 170 of, 416 Basal metabolism, effect of dioxoisoquinoline-4- dopamine levels in relation to pharmacologic carboxanilides on, 138 actions of L-dopa, 406 Bass, P., see Carlson, G. M., 367, 377 levels, of sodium 5-(1 ,3-dimethylbutyl) -5-ethyl Behavior, punished and unpunished, in pigeon, barbiturate, 170 effects of some benzodiazepines on, 397 of cattle, sheep, goats and swine, concentrations Bendroflumethiazide, effect on sodium transport of thiopental in, 128 and metabolism in toad bladder, 203 Bretylium Benzodiazepines blockade of release of H’-norepinephrine from effects on punished and unpunished behavior arterial strips, 62 in pigeon, 397 cocaine or, blockade of cardiac action of phen- lack of effect in inhibiting jumping activity in- ylephrine by, 274 dueed by sodium 5-(1 ,3-dimethylbutyl)-5- competitive inhibition of uptake of H1-beth- ethyl barbiturate, 170 anidine by heart slices, 100 Beta adrenergic blockade decreased potentiation of norepinephrine re- blockade of inotropic action of phenylephrine on spouses by cocaine after, 320 rabbit atria, 274 effect on amine retention in rat heart, 282 of chronotropic effects of nicotine and norepi- influence on responses of cat nictitating mem- nephrine in guinea-pig atria, 255 brane, 77 Beta adrenergic blocking drugs, reduction of jumping activity induced by sodium 5-(1,3- Broder, L. E., see Maren, T. H., 197 dimethylbutyl).5-ethyl barbiturate, 170 Brodie, B. B., see Koppanyi, T., 170 H.Bethanidine, uptake by heart slices, competi- Brody, M. J., see Boerth, R. C., 52 INDEX 429

Bromoacetylcholine, muscarinic and nicotinic -induced inhibition of contractile activity in activities of, 351 stomach and duodenum of dog, 367 Brown, B. R., Jr. and Crout, J. R. : The sym- potentiation of effects on rabbit aortic strips pathomimetic effect of gallamine on the heart, after inhibition of catechol-O-methyltraus 266 ferase with 4-tropolone acetamide, 320 BW 684-induced vasodilation in dogs, 297 release from spleen, effects of metabolic inhibi- tom on, 342 Calcium release resulting from administration of nico- influence on contracture produced by RP-12278, tine in dog, 377 44 retention in rat heart after bretylium, 282 inhibition of release of norepinephrine from iso- Catechol-Omethyltransfer, inhibition by lated rat iris by field stimulation in absence 4-tropolone acetamide in rabbit aortic strips, of, 332 320 Caidwell, R. W. and Goldberg, L. I. : An evalua- Cavanaugh, J. H., see Mitchell, J. R., 108 tion of the vasodilation produced by mephen- Cells, epithelial, effect of bendroflumethiazide on termine and certain other sympathomimetic sodium transport and metabolism in toad amines, 297 bladder, 203 Carbon dioxide, entry from blood into cerebro- Central nervous system, potentiation and inhibi- spinal fluid before and after inhibition of tion of some central actions of L-dopa by de- carbonic anhydrase, 197 carboxylase inhibitors, 406 Carbonic anhydrase, role in anion secretion into Cerebrospinal fluid cerebrospinal fluid, 197 in cattle, sheep, goats and swine, concentra. Cardiac glycosides tions of thiopental in, 128 effect on interaction of Ca with mitochondria, role of carbonic anhydrase in anion secretion 180 into, 197 six, effects on transmembrane potential and Chang, Y.-H., see Wiseman, E. H., 138 contractile characteristics of right ventricle Chiaini, J., see Wiseman, E. H., 138 of guinea pigs, 188 Chiou, C. Y. and Sastry, B. V. R. : Cholinergic Carlson, G. M., Ruddon, R. W., Hug, C. C., Jr. activities of halogeno_acetylcholines, 351 and Bass, P. : Effects of nicotine on gastric Chbordiazepoxide, effect on punished and im- antral and duodenal contractile activity in punished behavior in pigeon, 397 the dog, 367 Chloride, entry from blood into cerebrospinal Carlson, G. M., Ruddon, R. W., Hug, C. C., Jr., fluid before and after inhibition of carbonic Schmiege, S. K. and Bass, P. : Analysis of the anhydra,se, 197 site of nicotine action on gastric antral and Chborisondamine, blockade of hyperglycemia in duodenal contractile activity, 377 mice induced by sodium 5-(1 ,3-dimethyl- Carrageenan-induced foot edema of rat, interac- butyl)-5-ethyl barbiturate, 170 tions of anti-inflammatory drugs in, 423 Chloroacetylcholine, muscarinic and nicotinic ac- Castles, T. R., Loth, E., Crawford, C. R. and Lee, tivities of, 351 C. C. : The neuromuscular blocking properties p-Chloromercuribenzoate, effect on release of of the antimalarial agent, bis[(chloro-7”- norepinephrine from spleen, 342

quinolyl-4’ ‘)amino-2’-propylj-1 , 4 -piperazine, Chloroquine diphosphate, RP-12278 and, anti- 44 malarial agents, neuromuscular blocking Catecholamine(s) properties of, 44 adrenal, comparison of differential secretion Chiorpromazine by splanchnic nerve stimulation and cholin- effect on sodium transport in red cell ghosts, 211 ergic agents, 69 inhibition of metabolism of guanethidine and brain, synthesized from circulating H’-tyrosine, related agents by hepatic microsomes by, 108 daily rhythm in accumulation of, 416 Cholinergic agents, splanchnic nerve stimulation -depleting effect of guanethidine, antagonism and, comparison of differential secretion of by desipramine, 100 adrenal catecholamines by, 69 depletion, influence on inotropic action of Cocaine bretylium or, blockade of cardiac action of phenylephrine in rabbit atria, 274 phenylephrine by, 274 effects in rabbit aortic strips, antagonism by effect on retention of metaraminol in rat heart, phentolamine, 310 282 effects of denervation and fl-TM 10 on, in cat failure to inhibit positive inotropic response to nictitating membrane, 77 gallamine, 266 430 INDEX

failure to sensitize cat nictitating membrane to Dichloroisoproterenol, blockade of inotropic ac- methoxamine, 91 tion of phenylephrine on rabbit atria, 274 ineffectiveness in blocking a p11-induced in- Digitoxin, effect on transmembrane potential and crease in atrial norepinephrine turnover, 289 contractile characteristics of right ventricle phenoxybenzamine, tripelennamine and, effect of guinea pigs, 188 on release of histamine-C’4 and norepineph- Digoxin, effect on transmembrane potential and rine-H’, 52 contractile characteristics of right ventricle potentiation of sympathomimetics in rabbit of guinea pigs, 188 aortic strips, 320 Dihydroergotamine Convallatoxol, effect on transmembrane potential blockade of nicotine-induced increases in dura- and contractile characteristics of right yen- tion of action potentials in guinea-pig atria, tricle of guinea pigs, 188 255 Crawford, C. R., see Castles, T. R., 44 lack of effect on nicotine- and catecholamine- Crout, J. R., see Brown, B. R., Jr., 266 induced inhibition of contractile activity in Curare, lack of effect on contracture produced by stomach and duodenum of dog, 367 RP-12278, 44 Dihydro-ouabain, effect on transmembrane po- Cyanide, effect on release of norepinephrine from tential and contractile characteristics of right spleen, 342 ventricle of guinea pigs, 188 Cyanine 863, inhibition of renal tubular transport Dihydrostrophanthidinic acid, effect on interac- of morphine in chicken by, 224 tion of Ca with mitochondria, 180 Dimethylphenylpiperazinium D’Amour and Smith method, measurement of effect on adrenal catecholamine secretion, 69 analgesic efficacy and potency of pentazocine inhibition of contractile activity in stomach and nalorphine by, 154 and duodenum of dog, 367 Debrisoquin Dingell, J. V., see Mitchell, J. R., 108 competitive inhibition of uptake of H’-betha- Dinitrophenol, effect on release of norepinephrine nidine by heart slices, 100 in spleen during glucose deprivation, 342 guanethidine, guanoxan and, metabolism by Dioxoisoquinoline-4-carboxanilides, novel non- hepatic microsomes and inhibition by drugs, steroidal anti-inflammatory agents with a 108 species-specific effect on basal metabolism, 138 Decarboxylase inhibitors, potentiation and in- Dipyridamole, effect on sodium transport in red hibition of some central actions of L-dopa by, cell ghosts, 211 406 L-Dopa, some central actions of, potentiation and Decentralization, as a cause of supersensitivity to inhibition by decarboxylase inhibitors, 406 both methoxamine and norepinephrine in cat Drask#{243}czy, P. R., see Pluchino, S., 77 nictitating membrane, 91 Duodenum de Groat, W. C. : The actions of -y-aminobutyric of dog, stomach and, influence of nicotine on acid and related amino acids on mammalian contractile activity in, 377 autonomic ganglia, 384 of dog, stomach and, inhibition of contractile Denervation activity by nicotine and catecholamines in, failure to sensitize cat nictitating membrane to 367 methoxamine, 91 Dutta, S., see Ito, M., 188 of nictitating membrane of cat, effect of a-TM 10 on pharmacological, biochemical and Edema, foot, of rat, carrageenan-induced, inter- morphological changes induced by, 77 actions of anti-inflammatory drugs in, 423 Desipramine Emesis, induced by L-dopa, attentuation by de- competitive inhibition of uptake of H5-betha- carboxylase inhibitors, 406 nidine by heart slices, 100 Epinephrine decreased potentiation of norepinephrine re- inhibition of contractile activity in stomach sponses by cocaine after, 320 and duodenum of dog, 367 effect on sodium transport in red cell ghosts, 211 interactions with potentiating agents in rabbit inhibition of metabolism of guanethidine and related agents by hepatic microsomes by, 108 sortie strips, 320 Desmethylimipramine, effect on retention of norepinephrine and, comparison of differential metaraminol in rat heart, 282 secretion produced by splanchnic nerve Diazepam, effect on punished and unpunished stimulation and cholinergic agents, 69 behavior in pigeon, 397 Epithelial cells, effect of bendroflumethiazide on INDEX 431

sodium transport and metabolism in toad Glyceryl trinitrate, reduction in small vessel re- bladder, 203 sistance compared with effects of mephenter- Erythrocyte ghosts, human, drugs affecting so- mine and isoproterenol, 297 dium transport in, 211 Glycine, lack of effect on mammalian autonomic Ethacrynic acid, effect on sodium transport in ganglia, 384 red cell ghosts, 211 Glycogen, effect of bendroflumethiazide on trans- Ethereal sulfate, morphine, morphine and, in port in toad bladder, 203 chicken, mechanism of renal tubular trans- Glycosides port of, 224 cardiac, effect on interaction of Ca with mito- N-Ethylmaleimide, effect on release of norepi- chondria, 180 nephrine from spleen, 342 cardiac, six, effects on transmembrane potential Excitation-contraction coupling, of sartorius and and contractile characteristics of right yen- rectus abdominis muscle in frogs, effect of tricle of guinea pigs, 188 SKF 525-A on, 33 Goldberg, L. I., see Caldwell, R. W., 297 Eye, rat, release of norepinephrine from isolated Good, A. L., see Sharma, R. P., 128 iris by field stimulation, 332 Gracilis muscles, dog, isolated, perfused, effects of phenoxybenzamine, cocaine and tripelen- Farnebo, L.-O. and Hamberger, B. : Release of namine on release of histamine.C14 and nor- norepinephrine from isolated rat iris by field epinephrine-H’, 52 stimulation, 332 Gralla, E. J., see Wiseman, E. H., 138 Fleming, W. W. Grant, T. J., see Swingle, K. F., 423 see Peach, M. J., 289 Gray, W. D., Osterberg, A. C. and Scuto, T. J.: see Urquilla, P. R., 310 Measurement of the analgesic efficacy and Fluoroacetylcholine, muscarinic and nicotinic ac- potency of pentazocine by the D’Amour and tivities of, 351 Smith method, 154 Ford, G. D., see Peach, M. J., 289 Guanethidine Foulkes, D. M. : The metabolism of C”-ICI 54,450 decreased potentiation of norepinephrine re- (Myalex) in various species-An in v’ivo NIH spouses produced by cocaine or 4-tropobone shift, 115 acetamide after, 320 Fujimoto, J. M., see Watrous, W. M., 224 related agents and, blockade of adrenergic Furchgott, R. F., see Levin, J. A., 320 neurons and antagonism by drugs, 100 Furosemide, effect on sodium transport in red cell related agents and, metabolism by hepatic ghosts, 211 microsomes and inhibition by drugs, 108 Guanoxan, guanethidine, debrisoquin and, me- Gallamine, sympathomimetic effect on heart, 266 tabolism by hepatic microsomes and inhibi- Ganglia, autonomic, mammalian, actions of tion by drugs, 108 -y-aminobutyric acid and related amino acids Gut, of cattle, sheep, goats and swine, concentra- on, 384 tions of thiopental in, 128 Ganglionic blockade, effect of hexamethonium on biphasic effects of nicotine on action poten- 1144/68, effect on release of norepinephrine from tials in guinea-pig atria, 255 isolated rat iris by field stimulation, 332 Ganglionic blocking drugs, reduction of jumping Hamberger, B., see Farnebo, L.-O., 332 activity induced by sodium 5-(1,3-dimethyl- Heart butyl)-5-ethyl barbiturate, 170 action of phenylephrine, blockade by bretylium Gebber, G. L., see Klevans, L. R., 69 or cocaine, 274 Glands biphasic effect of nicotine on action potential adrenal, effects of splanchnic nerve stimulation repolarization in guinea-pig atria, 255 and cholinergic agents on secretion of cate- effects of lidocaine and quinidine on conduction cholamines by, 69 in Purkinje fibers, 239 adrenal, release of catecholamines in response effects of mephentermine, amphetamine, pseu- to nicotine, 377 doephedrine and phenpromethamine on con- Glucose tractile force in dogs, 297 deprivation, lack of effect on release of norepi- glycosides, effect on interaction of Ca with nephrine from spleen, 342 m.itochondria, 180 plasma, elevation in mice exhibiting jumping glycosides, six, effects on transmembrane poten- activity induced by sodium 5-(1,3-dimethyl- tial and contractile characteristics of right butyl)-5-ethyl barbiturate, 170 ventricle of guinea pigs, 188 432 INDEX

guinea-pig, effects of acidosis on chronotropic effects on inflammation induced by carragee- responses, norepinephrine storage and release nan, 423 in, 289 Ions, tetraethylammonium, actions on potassium rat, effect of bretylium on amine retention in, fluxes in frog sartorius muscle, 230 282 Iproniazid, effect on potentiation of responses to slices, uptake of H1-bethanidine by, competitive adrenergic amines produced by cocaine or inhibition by norepinephrine, guanethidine, 4-tropolone aeetamide in rabbit aortic strips, debrisoquin, bretylium, tyramine, metarami- 320 nol and desipramine, 100 Iris, rat, release by field stimulation of norepi- sympathomimetic effect of gallamine on, 266 nephrine from, 332 Hepatic microsomes , metabolism of guanethidine, Isoproterenol debrisoquin and guanoxan by, inhibition by and responses of denervated cat nictitating drugs, 108 membrane, 77 Hexamethonium lack of retention in rabbit aortic strips, 91 blockade of biphasic effect of nicotine on action reduction in small vessel resistance compared potentials in guinea-pig atria, 255 with effects of mephentermine and glyceryl failure to inhibit positive inotropic response to trinitrate, 297 gallamine, 266 Isostrophanthidin, effect on interaction of Ca Histamine-C”, release during baroreceptor-in- with mitochondria, 180 duced reflex vasodilatation, effects of phen- Ito, M., Hollander, P. B., Marks, B. H. and oxybenzamine, cocaine and tripelennamine Dutta, S. : The effects of six cardiac glycosides on, 52 on the transmembrane potential and contrac- Hollander, P. B., see Ito, M., 188 tile characteristics of the right ventricle of Hong, S. A., see Lee, K. S., 180 guinea pigs, 188 Hug, C. C., Jr., see Carlson, G. M., 367, 377 Hydrocortisone Jaques, L. W., see Swingle, K. F., 423 combination with other drugs, effects on inflam- mation induced by carrageenan, 423 Kang, D. H., see Lee, K. S., 180 decreased potentiation of norepinephrine re- Kelleher, R. T., see Wuttke, W., 397 sponses produced by 4-tropolone acetamide Kidney after, 320 of cattle, sheep, goats and swine, concentrations Hyperglycemia, in mice, induced by sodium of thiopental in, 128 5-(1 , 3-dimethylbutyl)-5-ethyl barbiturate, tubular transport of morphine and morphine blockade by chlorisondamine, pempidine, ethereal sulfate in chicken, mechanism of, 224 propranolol and phentolamine, 170 Kirpekar, S. M., Prat, J. C. and Yamamoto, H.: Hypothermia Effects of metabolic inhibitors on norepineph- effect on release of norepinephrine from spleen, rine release from the perfused spleen of the 342 cat, 342 induced by reserpine, reversal by L-dopa and Klevans, L. R. and Gebber, G. L. : Comparison enhancement of response by decarboxylase of differential secretion of adrenal catechola- inhibitors, 406 mines by splanchnic nerve stimulation and cholinergic agents, 69 C”-ICI 54,450 (Myalex) metabolism in various Kopin, I. J., see Krauss, K. R., 282 species, an in vzvo NIH shift, 115 Koppanyi, T., Maling, H. M., Saul, W. and Imipramine Brodie, B. B. : Jumping activity induced by effect on punished and unpunished behavior in sodium 5-(1 ,3-dimethylbutyl)-5-ethyl barbi- pigeon, 397 turate. I. The role of the sympathetic nervous effect on sodium transport in red cell ghosts, 211 system, 170 Inflammation, carrageenan-induced, interactions Krause, K. R., Kopin, I. J. and Weise, V. K. : The of anti-inflammatory drugs, 423 effect of bretylium on amine retention in rat lodoacetate, effect on sodium transport in red heart, 282 cell ghosts, 211 Kvam, D. C., see Swingle, K. F., 423 lodoacetic acid, effect on release of norepineph- rine from spleen, 342 Lactate, accumulation in toad bladder, effect of Iodoacetylcholine, muscarinic and nicotinic ac- bendroflumethiazide on, 203 tivities of, 351 Langer, S. Z., see Pluchino, S., 77 Indomethacin, combination with other drugs, Lee, C. C., see Castles, T. R., 44 INDEX 433

Lee, K. S., Hong, S. A. and Kang, D. H.: Effect nictitating, cat’s, methoxamine as a tool to of cardiac glycosides on interaction of Ca+ assess importance of intraneuronal uptake of with mitochondria, 180 l-norepinephrine in, 91 Lee, W. C., see Yoo, C. S., 274 resting potential, frog sartorius muscle, effect Levin, J. A. and Furchgott, R. F. : Interactions of tetraethylammonium ions on, 230 between potentiating agents of adrenergic Mephentermine, certain other sympathomimetic amines in rabbit aortic strips, 320 amines and, evaluation of vasodilation pro- Lidocaine duced by, 297 effect on conduction in canine Purkinje fibers Mepiperphenidol, inhibition of renal tubular and at ventricular muscle-Purkinje fiber transport of morphine in chicken by, 224 junction, 239 Metabolism effect on sodium transport in red cell ghosts, 211 basal , effect of dioxoisoquinoline-4-carboxani- C’4-procaine and, in intact and desheathed lides on, 138 sciatic nerve trunks, effects of pH gradients distribution and, of thiopental in cattle, sheep, on uptake and distribution of, 18 goats and swine, 128 procaine and, in intact and desheathed sciatic of C”-ICI 54,450 (Myalex) in various species, nerves, effects of pH gradients on action of, 1 an in vivo NIH shift, 115 Lilly 390-induced vasodilation in dogs, 297 of guanethidine, debrisoquin and guanoxan by Liver hepatic microsomes and inhibition by drugs, microsomes, metabolism of guanethidine, de- 108 brisoquin and guanoxan by, inhibition by of magnesium in rats, influence of morphine on, drugs, 108 122 microsomes, metabolism of thiopental by, in sodium transport and, in toad bladder, effect of cattle, sheep, goats and swine, 128 bendroflumethiazide on, 203 Loth, E., see Castles, T. R., 44 Metaraminol Lotti, V. J. and Porter, C. C. : Potentiation and competitive inhibition of uptake of H’-bethani- inhibition of some central actions of L(-). dine by heart slices, 100 dopa by decarboxylase inhibitors, 406 inhibition of metabolism of guanethidine and related agents by hepatic microsomes by, 108 Magnesium potentiation of effects by cocaine or 4-tropolone influence on contracture produced by RP- acetamide in rabbit aortic strips, 320 12278, 44 retention in rat heart after bretylium, 282 metabolism in rats, influence of morphine on, Methacholine, effect of nicotine on contractile 122 activity in stomach and duodenum of dog, 377 Maling, H. M., see Koppanyi, T., 170 Methamphetamine-induced vasodilation in dogs, Mandel, W. J., see Bigger, J. T., Jr., 239 297 Marchand, C., see Vachon, M., 122 Methoxamine, for assessing importance of intra- Maren, T. H. and Broder, L. E. : The role of car- neuronal uptake of l-norepinephrine in cat’s bonic anhydrase in anion secretion into cere- nictitating membrane, 91 brospinal fluid, 197 N-Methylnicotinamide, influence on renal tubular Marinobufagin, effect on interaction of Ca with transport of morphine in chicken, 224 mitochondria, 180 a-Methylnorepinephrine Marks, B. H., see Ito, M., 188 potentiation of effects on rabbit aortic strips Maxwell, R. A., see Trendelenburg, U., 91 after inhibition of catechol-O-methyltrans- May, D. G., see Watrous, W. M., 224 ferase with 4-tropolone acetamide, 320 McDougal, B. and Sullivan, L. P. : Studies of the retention in rat heart after bretylium, 282 effect of bendroflumethiazide on sodium trans- a-Methyloctopamine, retention in rat heart after port and metabolism in the toad bladder, 203 bretylium, 282 MeN A-343, inhibition of contractile activity in Methylphenidate-induced vasodilation in dogs, stomach and duodenum of dog, 367 297 Membrane(s) Microsomes effects of lidocaine and quiidine on conduction hepatic, metabolism of guanethidine, debriso- in canine Purkinje fibers and at ventricular quin and guanoxan by, inhibition by drugs, muscle-Purkinje fiber junction, 239 108 nictitating, cat’s, effect of $-TM 10 on pharma- liver, metabolism of thiopental by, in cattle, cological, biochemical and morphological sheep, goats and swine, 128 changes induced by denervation of, 77 Migliardi, J. R., see Wiseman, E. H., 138 434 INDEX

Mitchell, J. R. and Oates, J. A. : Guanethidine smooth, aortic, comparison of retentions of and related agents. I. Mechanism of the selec- methoxamine and norepinephrine in, 91 tive blockade of adrenergic neurons and its sympathomimetic effect of gallamine on heart, antagonism by drugs, 100 266 Mitchell, J. R., Cavanaugh, J. H., Dingell, J. V. vasodilation induced by mephentermine in and Oates, J. A. : Guanethidine and related dogs, 297 agents. II. Metabolism by hepatic microsomes Myalex (C’-ICI 54,450), metabolism in various and its inhibition by drugs, 108 species, an in vivo NIH shift, 115 Mitochondria, interaction of Ca with, effect of cardiac glycosides on, 180 Nalorphine hydrochloride MJ-1999, lack of effect on mephentermine-induced effect on increase in serum magnesium caused relaxation of rabbit portal vein, 297 by morphine, 122 Morphine measurement by D’Amour and Smith method influence on magnesium metabolism in rats, 122 of analgesic efficacy and potency of, 154 morphine ethereal sulfate and, in chicken, Nerve(s) mechanism of renal tubular transport of, 224 adrenergic, release of norepinephrine from iso- Muscle(s) lated rat iris by field stimulation, 332 biphasic effect of nicotine on action potential antagonism by phentolamine of effects of nor- repolarization in guinea-pig atria, 255 epinephrine released from adrenergic ter- blocking action of chloroquine diphosphate and minals in aortic strips, 310 RP-12278, 44 neuromuscular blockade produced by chioro- cardiac, rat, retention of amines after brety- quine diphosphate, 44 hum, 282 sciatic, frog, sheathed and desheathed, effect contraction in isolated rabbit main pulmonary of SKF 525-A on conduction, 33 artery, release of H’-norepinephrine in rela- sciatic, intact and desheathed, effects of pH tion to, 62 gradients on action of procaine and lidocaine effects of acidosis on chronotropic responses, in, 1 norepinephrine storage and release in isolated splanchnic, stimulation, cholinergic agents and, guinea-pig atria, 289 comparison of differential secretion of adrenal gracilis, dog, isolated, perfused, effects of phe- catecholamines by, 69 noxybenzamine, cocaine and tripelennamine stimulation, effects of metabolic inhibitors on on release of histamine-C’4 and norepineph- norepinephrine release from spleen, 342 rine-111, 52 sympathetic, stimulation, effects of phenoxy- heart, glycosides, six, effects on transmembrane benzamine, cocaine and tripelennamine on potential and contractile characteristics of release of norepinephrine-H during, 52 right ventricle of guinea pigs, 188 trunks, sciatic, intact and desheathed, effects influence of nicotine on gastrointestinal activity of pH gradients on uptake and distribution in dog, 377 of C14-procaine and lidocaine in, 18 inhibition of contractile activity in stomach Nervous system and duodenum of dog by nicotine and cats- central, potentiation and inhibition of some cholamines, 367 central actions of L-dopa by decarboxylase interactions between potentiating agents and inhibitors, 406 adrenergic amines in rabbit aortic strips, 320 sympathetic, role of, jumping activity induced muscarmnic and nicotinic activities of halogeno- by sodium 5-(1 ,3-dimethylbutyl)-5-ethyl bar- acetyleholines, 351 biturate, 170 of cattle, sheep, goats and swine, concentrations Neuromuscular blockade of thiopental in, 128 produced by several halogeno-acetyicholines, -Purkinje fiber junction, ventricular, effect of 351 lidocaine on conduction in, 239 properties of antimalarial agents, chloroquine release of norepinephrine from isolated rat iris diphosphate and RP-12278, 44 by field stimulation, 332 Neurons, adrenergic, blockade by guanethidine sartorius and rectus abdominis, effect of SKF and related agents and antagonism by drugs, 525-A on excitation-contraction coupling in 100 frogs, 33 Nialamide, inhibitory effects on release of nor- sartorius, frog, actions of tetraethylammonium epinephrine from isolated rat iris by field ions on potassium fluxes in, 230 stimulation, 332 smooth, aortic, antagonism of phentolamine Nicotine against exogenously administered and en- action on gastric antral and duodenal contrac- dogenously released norepinephrine in, 310 tile activity, analysis of site of, 377 INDEX 435

biphasic effect on action potential repolariza- decreased potentiation of norepinephrine re- tion in electrically driven guinea-pig atria, sponses by cocaine after, 320 255 effect on interaction of Ca with mitochondria, effect on adrenal catecholamine secretion, 69 180 effects on gastric antral and duodenal contrac- effect on release of norepinephrine from spleen, tile activity in dog, 367 342 Nictitating membrane effect on sodium transport and metabolism in cat’s, effect of a-TM 10 on pharmacological, toad bladder, 203 biochemical and morphological changes in- effect on sodium transport in red cell ghosts, 211 duced by denervation of, 77 effect on transmembrane potential and con- cat’s, methoxamine as a tool to assess impor- tractile characteristics of right ventricle of tance of intraneuronal uptake of l-norepi- guinea pigs, 188 nephrine in, 91 Oxygen, consumption in toad bladder, effect of NIH shift, in vivo, metabolism of C’-ICI 54,450 bendroflumethiazide on, 203 (Myalex) in various species, 115 Nitrazepam, effect on punished and unpunished Pappano, A. J. : Bipha.sic effect of nicotine on behavior in pigeon, 397 action potential repolarization in electrically Norepinephrine driven guinea-pig atria, 255 and responses of denervated cat nictitating Peach, M. J., Ford, G. D., Azzaro, A. J. and Flem- membrane, 77 ing, W. W. : The effects of acidosis on chrono- competitive inhibition of uptake of H’-bethani- tropic responses, norepinephrine storage and dine by heart slices, 100 release in isolated guinea-pig atria, 289 diurnal variations in accumulation in brain, 416 Pempidine, blockade of hyperglycemia in mice effect on action potential of guinea-pig atria, 255 induced by sodium 5-(1 ,3-dimethylbutyl)-5- epinephrine and, comparison of differential ethyl barbiturate, 170 secretion produced by splanchnic nerve Pentazocine, measurement by D’Amour and stimulation and cholinergic agents, 69 Smith method of analgesic efficacy and exogenously administered and endogenously potency of, 154 released, in rabbit aortic strips, antagonism pH of phentolamine against, 310 gradients, effects on action of procaine and inhibition of contractile activity in stomach and lidocaine in intact and desheathed sciatic duodenum of dog, 367 nerves, 1 interactions with potentiating agents in rabbit gradients, effects on uptake and distribution of aortic strips, 320 C’4-procaine and lidocaine in intact and retention in rat heart after bretylium, 282 desheathed sciatic nerve trunks, 18 reversal of tachyphylaxis by, 266 -induced increase in atrial norepinephrine turn- storage, chronotropic responses, release and, in over, ineffective blocking action by cocaine, isolated guinea-pig atria, effects of acidosis on, 289 289 Phenothiazines, inhibition of metabolism of Norepinephrine-H5 guanethidine and related agents by hepatic release during sympathetic nerve stimulation, microsomes by, 108 effects of phenoxybenzamine, cocaine and Phenoxybenzamine tripelennamine on, 52 cocaine, tripelennamine and, effect on release release in arterial strips studied by technique of histamine-C’4 and norepinephrine-H’, 52 of superfusion and transmural stimulation, 62 effect on transmural stimulation-induced H-

release from perfused spleen of cat , effects of norepinephrine release from arterial strips, 62 metabolic inhibitors on, 342 lack of effect on nicotine- and catecholamine- t-Norepinephrine, in cat’s nictitating membrane, induced inhibition of contractile activity in methoxamine as a tool to assess importance of stomach and duodenum of dog, 367 intraneuronal uptake of, 91 Phenpromethamine, effect on heart force in dogs, 297 Phentolamine Oates, J. A., see Mitchell, J. R., 100, 108 antagonism against exogenously administered Octopamine, retention in rat heart after bre- and endogenously released norepinephrine in tylium, 282 rabbit aortic strips, 310 Oligomycin, effect on sodium transport in red cell blockade of hyperglycemia in mice induced by ghosts, 211 sodium 5-(1 ,3-dimethylbutyl)-5-ethyl bar- Osterberg, A. C., see Gray, W. D., 154 biturate, 170 Ouabain competitive blockade of effect of methoxamine 436 INDEX

and norepinephrine on cat’s nictitating blockade of hyperglycemia in mice induced by membrane, 91 sodium 5-(1 ,3-dimethylbutyl)-5-ethyl barbi- Phenylbutazone turate, 170 combination with other drugs, effects on in- blockade of inotropic action of phenylephrine on flammation induced by carrageenan, 423 rabbit atria, 274 comparison of anti-inflammatory actions with influence on effects of nicotine and norepine- those of dioxoisoquinoline-4-carboxanilides, phrine on action potentials of guinea-pig 138 atria, 255 Phenylephrine inhibition of positive inotropic effect of gal- and responses of denervated cat nictitating lamine by, 266 membrane, 77 lack of influence on mephentermine-induced cardiac action of, blockade by bretylium or vasodilation in dogs, 297 cocaine, 274 Proscillaridin, effect on transmembrane potential lack of effect of catechol-O-methyltransferase and contractile characteristics of right inhibition by 4-tropolone acetamide on ventricle of guinea pigs, 188 responses in rabbit aortic strips, 320 Proteins, plasma, binding of thiopental in cattle, Picrotoxin, antagonism of effects of 7-amino- sheep, goats and swine, 128 butyric acid on mammalian autonomic Protriptyline, inhibition of metabolism of guan- ganglia, 384 ethidine and related agents by hepatic Plasma microsomes by, 108 glucose, elevation in mice exhibiting jumping Pseudoephedrine, effect on heart force in dogs, 297 activity induced by sodium 5-(1,3-dimethyl- Pulmonary artery, main, isolated, rabbit, release butyl)-5-ethyl barbiturate, 170 of H1-norepinephrine in relation to muscle proteins, binding of thiopental in cattle, sheep, contraction in, 62 goats and swine, 128 Purkinje fibers, canine, ventricular muscle- Pluchino, S., Van Orden, L. S., III, Drask#{243}czy, Purkinje fiber junction and, effect of lidocaine P. R., Langer, S. Z. and Trendelenburg, U.: on conduction in, 239 The effect of a-TM 10 on the pharmacological, biochemical and morphological changes in- Quiidine, effect on conduction at ventricular duced by denervation of the nictitating mem- muscle-Purkinje fiber junction, 239 brane of the cat, 77 Pluchino, S., see Trendelenburg, U., 91 Rao, S. N., see Askari, A., 211 Porter, C. C., see Lotti, V. J., 406 Rectus abdominis muscle, sartorius and, effect of Potassium SKF 525-A on excitation-contraction coupling diffusion in desheathed frog and toad sciatic in frogs, 33 nerves, 1 Reflex vasodilatation, baroreceptor-induced, fluxes, in frog sartorius muscle, actions of effects of phenoxybenzamine, cocaine and tetraethylammonium ions on, 230 tripelennamine on release of histamine-C” -induced contracture, blockade by SKF 525-A in during, 52 frog rectus abdominis muscle, 33 Renal blood flow, effects of mephentermine and -induced release of norepinephrine from spleen, certain other sympathomimetic amines on, 297 influence of metabolic inhibitors, 342 Reserpine influence on contracture produced by RP-12278, abolition of nicotine-induced inhibition of 44 contractile activity in stomach and duodenum Prat, J. C., see Kirpekar, S. M., 342 of dog by, 367 Probenecid, lack of effect on renal tubular trans- depletion of catecholamines from rabbit atria, port of morphine and excretion of morphine influence on inotropic action of phenylephrine, ethereal sulfate in chicken, 224 274 Procaine effect of potentiation of responses to adrenergic effect on sodium transport in red cell ghosts, 211 amines produced by cocaine or 4-tropolone lidocaine and, in intact and desheathed sciatic acetamide in rabbit sortie strips, 320 nerves, effects of pH gradients on action of, 1 -induced hypothermia, reversal by L-dopa and C’4-Procaine, lidocaine and, in intact and de- enhancement of response by decarboxylase sheathed sciatic nerve trunks, effects of pH inhibitors, 406 gradients on uptake and distribution of, 18 induction of vasoconstriction by certain ad- Pronethalol, decreased potentiation of norepine- renergic stimulants after, 297 phrine responses by cocaine after, 320 inhibition of positive inotropic effect of gala- Propranolol mine by, 266 INDEX 437

inhibitory effects on release of norepinephrine Spleen, perfused, cat, effects of metabolic in- from isolated rat iris by field stimulation, 332 hibitors on norepinephrine release from, 342 RP-12278, bis[(chboro-7’-quinolyl-4’)amino-2’- Stitzel, R. E., see IJrquilla, P. R., 310 propyl]-1 ,4-piperazine, antimalerial agent, Stomach neuromuscular blocking properties of, 44 of dog, duodenum and, influence of nicotine on Ruddon, R. W., see Carlson, G. M., 367, 377 contractile activity in, 377 Ryan, M. J., see Boerth, R. C., 52 of dog, duodenum and, inhibition of contractile activity by nicotine and catecholamines in, Salicylate, combination with other drugs, effects 367 on inflammation induced by carrageenan, 423 Stowe, C. M., see Sharma, R. P., 128 Sartorius muscle Strobel, G. E. and Bianchi, C. P. : The effects of pH frog, actions of tetraethylammonium ions on gradients on the action of procaine and potassium fluxes in, 230 lidocaine in intact and desheathed sciatic rectus abdominis and, effect of SKF 525-A on nerves, 1 excitation-contraction coupling in frogs, 33 Strobel, G. E. and Bianchi, C. P. : The effects of Sastry, B. V. R., see Chiou, C. Y., 351 pH gradients on the uptake and distribution Saul, W., see Koppanyi, T., 170 of C14-procaine and lidocaine in intact and Schmiege, S. K., see Carlson, G. M., 377 desheathed sciatic nerve trunks, 18 Sciatic nerve(s) Strophanthidin, effect on interaction of Ca with frog, sheathed and desheathed, effect of SKF mitochondria, 180 525-A on conduction, 33 Strychnine, lack of effect on responses of main- intact and desheathed, effects of pH gradients malian autonomic ganglia to -y-aminobutyric on action of procaine and lidocaine in, 1 acid, 384 trunks, intact and desheathed, effects of pH Su, C. and Bevan, J. A. : The release of H-nor- gradients on uptake and distribution of C14- epinephrine in arterial strips studied by the procaine and lidocaine in, 18 technique of superfusion and transmural Scilliroside, effect on interaction of Ca with stimulation, 62 mitochondria, 180 Suarez-Kurtz, G. and Bianchi, C. P. : Sites of Scuto, T. J., see Gray, W. D., 154 action of SKF 525-A in nerve and muscle, 33 Sharma, R. P., Stowe, C. M. and Good, A. L.: Succinylcholine, lack of effect on contracture Studies on the distribution and metabolism produced by RP-12278, 44 of thiopental in cattle, sheep, goats and swine, Sulfhydryl inhibitors, effects on release of norepi- 128 nephrine from spleen, 342 Sinoatrial node, biphasic effect of nicotine on Sullivan, L. P., see McDougal, B., 203 action potential repolarization in guinea pig, Swingle, K. F., Grant, T. J., Jaques, L. W. and 255 Kvam, D. C. : Interactions of anti-infiam- SKF 525-A, sites of action in nerve and muscle, 33 matory drugs in carrageenan-induced foot Smooth muscle edema of the rat, 423 aortic, antagonism of phentolamine against Sympathetic nerve, stimulation, effects of phen- oxybenzamine, cocaine and tripelennamine exogenously administered and endogenously on release of norepinephrine-H’ during, 52 released norepinephrine in, 310 Sympathetic nervous system, role of, jumping aortic, comparison of retentions of methoxamine activity induced by sodium 5-(1 , 3-dimethyl- and norepinephrine in, 91 butyl)-5-ethyl barbiturate, 170 Sodium Sympathomimetic amines, mephentermine and, transport and metabolism in toad bladder, effect evaluation of vasodilation produced by, 297 of bendroflumethiazide on, 203 Synephrine, lack of effect of catechol-O-methyl- transport in human erythrocyte ghosts, drugs transferase inhibition by 4-tropolone aceta- affecting, 211 mide on responses in rabbit aortic strips, 320 Sodium 5-(1,3-dimethylbutyl)-5-ethyl barbitu- rate, jumping activity induced by, role of Tachyphylaxis, reversal by norepinephrine, 266 sympathetic nervous system, 170 Takaha,shi, S., see Yanagita, T., 163 Splanchnic nerve, stimulation, cholinergic agents Temperature, elevation in mice exhibiting jump- and, comparison of differential secretion of ing activity induced by sodium 5-(1,3-di- adrenal catecholamines by, 69 methylbutyl)-5-ethyl barbiturate, 170 Splanchnicotomy, influence on nicotine-induced Tetracaine, effect on sodium transport in red cell inhibition of contractile activity in stomach ghosts, 211 and duodenum of dog, 377 Tetraethylammonium 438 INDEX

effect on action potentials and cycle length in Urine, of cattle, sheep, goats and swine, excretion guinea-pig atria, 255 of thiopental in, 128 ions, actions on potassium fluxes in frog sarto- Urquilla, P. R., Stitzel, R. E. and Fleming, W. W.: rius muscle, 230 The antagonism of phentolamine against Tetrodotoxin, blockade of release of H’-norepi- exogenously administered and endogenously nephrine by arterial strips, 62 released norepinephrine in rabbit aortic Thiazide, effect of bendroflumethiazide on sodium strips, 310 transport and metabolism in toad bladder, 203 Thiopental, studies on distribution and metabo- Vachon, M. and Marchand, C. : The influence of lism in cattle, sheep, goats and swine, 128 morphine on magnesium metabolism in rats, Tissue, adipose, of cattle, sheep, goats and swine, 122 concentrations of thiopental in, 128 Vagotomy, influence on nicotine-induced inhibi- a-TM 10, effect on pharmacological, biochemical tion of contractile activity in stomach and and morphological changes induced by duodenum of dog, 377 denervation of nictitating membrane of cat, Van Orden, L. S., III, see Pluchino, S., 77 77 Vasodilation, produced by mephentermine and Tolazoline, reduction of nicotine- and catechola- certain other sympathomimetic amines, mine-induced inhibition of contractile activity evaluation of, 297 in stomach and duodenum of dog by, 367 Vein, portal, rabbit, relaxation by mephentermine, Transverse tubules, frog sartorius muscle, effect 297 of tetraethylammonium ions on, 230 Ventricle, right, of guinea pigs, effects of six Trendelenburg, U., Maxwell, R. A. and Pluchino, cardiac glycosides on transmembrane po- S. : Methoxamine as a tool to assess the im- tential and contractile characteristics of, 188 portance of intraneuronal uptake of 1-norepi- Volle, R. L. : The actions of tetraethylammonium nephrine in the cat’s nictitating membrane, ions of potassium fluxes in frog sartorius 91 muscle, 230 Trendelenburg, U., see Pluchino, S., 77 Watrous, W. M., May, D. G. and Fujimoto, J. M.: Tripelennamine Mechanism of the renal tubular transport of decreased potentiation of norepinephrine re- morphine and morphine ethereal sulfate in the sponses by cocaine after, 320 chicken, 224 phenoxybenzamine, cocaine and, effect on Weise, V. K., see Krause, K. R., 282 release of histamine-C” and norepinephrine- Wiseman, E. H., Gralla, E. J., Chiaini, J., H, 52 Migliardi, J. R. and Chang, Y.-H. : Dioxoiso- 4-Tropolone acetamide, increase of contractile quinoline-4-carboxanilides, novel nonsteroidal responses of adrenergic amines in rabbit anti-inflammatory agents with a species- aortic strips, 320 specific effect on basal metabolism, 138 d-Tubocurarine Wurtman, R. J., see Zigmond, M. J., 416 failure to inhibit positive inotropic response to Wuttke, W. and Kelleher, R. T. : Effects of some gallamine, 266 benzodiazepines on punished and unpunished lack of effect on eontracture produced by RP- behavior in the pigeon, 397 12278, 44 Tyramine Yamamoto, H., see Kirpekar, S. M., 342 antagonism of effects by phentolamine in rabbit Yanagita, T. and Takahashi, S. : Development of sortie strips, 310 tolerance to and physical dependence on competitive inhibition of uptake of H3-bethani- barbiturates in rhesus monkeys, 163 dine by heart slices, 100 Yoo, C. S. and Lee, W. C.: Blockade of the cardiac effects of acidosis on chronotropic responses to, action of phenylephrine by bretylium or 289 cocaine, 274 Tyrosine, circulating, daily rhythm in accuinula- tion of brain catecholamines synthesized from, Zigmond, M. J. and Wurtman, R. J. : Daily rhythm 416 in the accumulation of brain catecholamines Tyrosine hydroxylase, influence of H44/68 on, 332 synthesized from circulating H5-tyrosine, 416