20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis

20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis

Irina Brouda, Brenda L. Edison, Barbara A. Green NeoStrata Company, Inc., Princeton, NJ, USA

Introduction Clinical Studies Summary

Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, gluconolactone, and maltobionic acid, cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing. 1 Winter Xerosis on the Leg Severe Hyperkeratosis of the Heel Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. in severe dry skin conditions. 2 ­ PDS Cream markedly improved the Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 have a profound effect on stratum corneum barrier function. Select AHAs reduce thickened skin of winter xerosis, heel corneocyte cohesion and promote desquamation and have been shown to significantly hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic hyperkeratosis, and X-linked ichthyosis. 4 PHAs and BAs are hygroscopic substances in case studies. that reduce transepidermal water loss and protect against external insults by strengthening the skin barrier. 5,6,7 A well formulated product containing AHAs, PHAs, ­ PDS Cream was better and faster at and BAs can normalize epidermal thickness, restore normal stratum corneum barrier descaling psoriatic plaques and improving function, and promote better water retention. disease severity than a prescription descaling cream containing 6% salicylic A high-strength, cosmetically elegant skincare cream containing a 20% acid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks address the challenge of problem dry skin conditions. This poster reviews (once-a-day application) the effects of this high strength AHA/PHA/BA cream on the clinical ­ PDS Cream is a highly effective, PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after cosmetically elegant topical treatment presentation of common dry skin conditions including winter xerosis and an overnight application of PDS Cream for 3 weeks. hyperkeratosis of the heels as well as more severe hyperkeratotic for a range of common as well as conditions such as psoriasis vulgaris and lamellar ichthyosis. less common mild to severe dry skin Lamellar Ichthyosis Psoriasis Vulgaris conditions seen in dermatological practice. An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with Test Product PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaque psoriasis used PDS Cream and 6% salicylic acid cream appearance and texture of the treated skin. The stratum corneum showed (Salex ® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, PDS Cream reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice References (Problem Dry Skin Cream, NeoStrata ® Company, Inc, Princeton, NJ, USA) daily for 2 weeks. 8 At the end of therapy, PDS Cream reduced scaling and Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Key Benefit Ingredients salicylic acid cream. Clin Dermatol . 2004;5(1):17-29. 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol . 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin 3. Van Scott EJ and Yu RJ. α-Hydroxyacids, polyhydroxy acids, aldobionic Psoriatic Plaque on the Left Knee acids and their topical actions. In Baran R and Maibach HI, editors: – Exfoliation Textbook of Cosmetic Dermatology, 3rd Edition , London and New York, 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with -hydroxy acids and Alpha hydroxy acids acid, lactic acid, and α and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch mandelic acid Dermatol . 1974;110:586-590. thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol . 1997 Dec;137(6):934-8. 5% blend of – Light exfoliation Poly hydroxy / 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition , 2009, bionic acids Elsevier, Inc. maltobionic acid – Skin barrier strengthening 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful yet gentle skincare ingredient with multiple benefits to protect skin and – Antioxidant reverse the visible signs of aging. Poster presented at the Summer Vitamin E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology , Chicago, IL, – Emollient August 4-8, 2010. 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness hydroxy acid cream to reduce scaling of lesions associated with moderate, chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of Emollient/occlusive 20% blend of and dryness on contact the American Academy of Dermatology , Miami, FL, March 5 – 9, 2010. vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks of moisturization (twice-a-day application)

After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Dermatology , New Orleans, LA, February 4-8, 2011. P1619 20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis Irina Brouda,20% Brenda L.Alpha/Poly Edison, Barbara A. Green Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis NeoStrata Company, Inc., Princeton, NJ, USA Irina Brouda, Brenda L. Edison, Barbara A. Green Introduction Clinical Studies Summary NeoStrata Company, Inc., Princeton, NJ, USA Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, gluconolactone, and maltobionic acid, cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.1Introduction Winter Xerosis on the Leg Severe Hyperkeratosis of the Heel Clinical Studies Summary Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. in severe dry skin conditions.2 Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ ­ PDS Cream markedly improved the PDS Cream contains a carefully selected Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs)symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are clinical appearance and feel of dry scaly 3 20% combination of alpha/poly/bionic have a profound effect on stratum corneum barrier function. Select AHAs reduce PDS Cream wasthickened tested skinon dry of winter winter xer skin.osis, Significantheel improvement A female volunteer treated hyperkeratotic heels with an overnight corneocyte cohesion and promote desquamation and have been shown to significantlymarked by increased corneocyte cohesion, decreased rates of desquamation, low in the appearancehyperkeratosis, and textur ande of lamellar treated ichthyosis skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely hydroxy acids, including glycolic acid, improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolyticsurface lipid content, and poor water retention in the stratum corneum. Individuals 4 2 applications in case24 hours studies. in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, hyperkeratosis, and X-linked ichthyosis. PHAs and BAs are hygroscopic substancessuffering from severe disorders of hyperkeratinization have unusually dry, rough, that reduce transepidermal water loss and protect against external insults by gluconolactone, and maltobionic acid, strengthening the skin barrier.5,6,7 A well formulated product containing AHAs, PHAs,cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.1 ­ PDS CreamWinter was better Xer andosis faster on atthe Leg Severe Hyperkeratosis of the Heel and BAs can normalize epidermal thickness, restore normal stratum corneum barrierOver-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness descaling psoriatic plaques and improving in a highly emollient vehicle. function, and promote better water retention. disease severity than a prescription 2 in severe dry skin conditions. descaling cream containing 6% salicylic A high-strength, cosmetically elegant skincare cream containing a 20% acid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks ­ PDS Cream markedly improved the address the challenge of problem dry skin conditions. This poster reviewsAlpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs)(once-a-day application) clinical appearance and feel of dry scaly the effects of this high strength AHA/PHA/BA cream on the clinical 3 ­ PDS Cream is a highly effective, have a prPDSofound Cream impreffectoves drony, flakystratum winter skincor withneum 2 applications. barrier function. SelectDry and scaly AHAs heels r becomeeduce soft and smooth after cosmetically elegant topical treatment presentation of common dry skin conditions including winter xerosis and an overnight application of PDS Cream for 3 weeks. thickened skin of winter xerosis, heel corneocyte cohesion and promote desquamation and have been shown to significantly for a range of common as well as hyperkeratosis of the heels as well as more severe hyperkeratotic hyperkeratosis, and lamellar ichthyosis conditions such as psoriasis vulgaris and lamellar ichthyosis. improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic less common mild to severe dry skin conditions seen in dermatological Lamellar Ichthyosis 4 Psoriasis Vulgaris in case studies. hyperkeratosis, and X-linked ichthyosis. PHAs and BAs are hygroscopic substances practice. An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with Test Product that reducePDS Cr eamtransepidermal twice daily for 2 weeks water with significant loss impr andovement pr otectin the againstmoderate exter plaquenal psoriasisinsults used by PDS Cream and 6% salicylic acid cream strengtheningappearance the and textur skine of barrierthe treated. 5,6,7skin. TheA stratumwell formulatedcorneum showed product(Salex containing® (6% Salicylic Acid) AHAs, Cream, Coria PHAs, Laboratories, Ltd., Forth Worth, PDS Cream reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice References ­ PDS Cream was better and faster at (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton, NJ, USA) and BAs can normalize epidermal thickness, restore normaldaily for stratum 2 weeks.8 At cor the endneum of therapy barrier, PDS Cream reduced scaling and descaling psoriatic plaques and improving Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Key Benefit Ingredients function, and promote better water retention. salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry disease severity than a prescription skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic descaling cream containing 6% salicylic Psoriatic Plaque on the Left Knee acids and their topical actions. In Baran R and Maibach HI, editors: A high-strength, cosmetically elegant skincare cream containing a 20% Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation acid in a controlled clinical trial. 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Alpha hydroxy acids acid, lactic acid, and combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch mandelic acid Dermatol. 1974;110:586-590. (once-a-day application) thickness address the challenge of problem dry skin conditions. This poster reviews 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. ­ PDS Cream is a highly effective, the effects of this high strength AHA/PHA/BA cream on the clinical 1997 Dec;137(6):934-8. 5% blend of – Light exfoliation PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after Poly hydroxy / 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy cosmetically elegant topical treatment gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, bionic acids presentation of common dry skin conditions including winter xerosis and Elsevier, Inc. an overnight application of PDS Cream for 3 weeks. maltobionic acid – Skin barrier strengthening 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful for a range of common as well as hyperkeratosis of the heels as well as more severe hyperkeratotic yet gentle skincare ingredient with multiple benefits to protect skin and – Antioxidant reverse the visible signs of aging. Poster presented at the Summer less common mild to severe dry skin Vitamin E Tocopheryl acetate conditions such as psoriasis vulgaris and lamellar ichthyosis. Academy Meeting of the American Academy of Dermatology, Chicago, IL, – Emollient August 4-8, 2010. Lamellar Ichthyosis8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, Psoriasis Vulgaris conditions seen in dermatological bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness hydroxy acid cream to reduce scaling of lesions associated with moderate, practice. Emollient/occlusive 20% blend of and dryness on contact chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of An 18-year-oldthe male American Academypatient of Dermatology with lamellar, Miami, FL, Mar chichthyosis 5 – 9, 2010. was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks of moisturization Test Product (twice-a-day application)PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaque psoriasis used PDS Cream and 6% salicylic acid cream appearance and texture of the treated skin. The stratum corneum showed (Salex® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine PDS Cream reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice PDS Cream reduces scaling and improves overall severity of References and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and® smoothes 8 (Problem Dry Skinthe hyperkeratotic Cream, NeoStrataskin of lamellar ichthyosis.Company, Inc, Princeton,psoriasis NJ, symptoms USA) after 2 weeks of twice daily use. daily for 2 weeks. At the end of therapy, PDS Cream reduced scaling and Poster exhibit at the 69th Annual Meeting of the American Academy of DermatologySkin, New Orleans, Af LA,fected February 4-8, 2011. by LamellarP1619 Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic acids and their topical actions. In Baran R and Maibach HI, editors: Psoriatic Plaque on the Left Knee Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Alpha hydroxy acids acid, lactic acid, and and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch mandelic acid Dermatol. 1974;110:586-590. thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. 1997 Dec;137(6):934-8. 5% blend of – Light exfoliation Poly hydroxy / 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, bionic acids Elsevier, Inc. maltobionic acid – Skin barrier strengthening 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful yet gentle skincare ingredient with multiple benefits to protect skin and – Antioxidant reverse the visible signs of aging. Poster presented at the Summer Vitamin E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology, Chicago, IL, – Emollient August 4-8, 2010. 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness hydroxy acid cream to reduce scaling of lesions associated with moderate, chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of Emollient/occlusive 20% blend of and dryness on contact the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks of moisturization (twice-a-day application)

After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Dermatology, New Orleans, LA, February 4-8, 2011. P1619 20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis

Irina Brouda, Brenda L. Edison, Barbara A. Green NeoStrata Company, Inc., Princeton, NJ, USA

Introduction Clinical Studies Summary

Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, gluconolactone, and maltobionic acid, cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.1 Winter Xerosis on the Leg Severe Hyperkeratosis of the Heel Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. in severe dry skin conditions.2 ­ PDS Cream markedly improved the Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 have a profound effect on stratum corneum barrier function. Select AHAs reduce thickened skin of winter xerosis, heel corneocyte cohesion and promote desquamation and have been shown to significantly hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic hyperkeratosis, and X-linked ichthyosis.4 PHAs and BAs are hygroscopic substances in case studies. that reduce transepidermal water loss and protect against external insults by strengthening the skin barrier.5,6,7 A well formulated product containing AHAs, PHAs, ­ PDS Cream was better and faster at and BAs can normalize epidermal thickness, restore normal stratum corneum barrier descaling psoriatic plaques and improving function, and promote better water retention. disease severity than a prescription descaling cream containing 6% salicylic A high-strength, cosmetically elegant skincare cream containing a 20% acid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks 20% Alpha/Poly Hydraddressoxy the Acid challenge Cream of prImproblemoves dry skinthe conditions.Symptoms This of poster Recalcitrant reviews Hyperkeratosis (once-a-day application) ­ the effects of this highIrina str Brouda,ength Brenda AHA/PHA/BA L. Edison, Barbara cr A.eam Green on the clinical PDS Cream is a highly effective, NeoStrata Company, Inc., Princeton, NJ, USA PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after cosmetically elegant topical treatment presentation of common dry skin conditions including winter xerosis and an overnight application of PDS Cream for 3 weeks. hyperkeratosis of the heels as well as more severe hyperkeratotic for a range of common as well as Introduction conditionsClinical such Studiesas psoriasis vulgaris and lamellar ichthyosis. Summary less common mild to severe dry skin Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis Lamellar­ PDS Ichthyosis Cream contains a carefully selected Psoriasis Vulgaris conditions seen in dermatological symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, practice. surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. An 18-yearlactic-old acid, male mandelic patient acid, with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with suffering from severe disorders of hyperkeratinization have unusually dry, rough, 1 PDS Creamgluconolactone, twice daily and for maltobionic 2 weeks acid, with significant improvement in the moderate plaque psoriasis used PDS Cream and 6% salicylic acid cream cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.Test Product Winter Xerosis on the Leg Severe Hyperkeratosis of the Heel Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness appearancein a highlyand texturemolliente ofvehicle. the treated skin. The stratum corneum showed (Salex® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, 2 in severe dry skin conditions. PDS Cream reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice References ® ­ PDS Cream markedly improved the Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids(Pr (BAs)oblem Dry Skin Cream, NeoStrata Company, Inc, Princeton, NJ, USA) clinical appearance and feel of dry scaly daily for 2 weeks.8 At the end of therapy, PDS Cream reduced scaling and have a profound effect on stratum corneum barrier function.3 Select AHAs reduce thickened Skinskin of Afwinterfected xerosis, by heel Lamellar Ichthyosis 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J corneocyte cohesion and promote desquamation and have been shown to significantly improved overall psoriasis severity significantly better and faster than 6% hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. hyperkeratosis, and X-linked ichthyosis.4 PHAs and BAs are hygroscopic substances in case studies. 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry that reduce transepidermal water loss and protect against external insults by skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. strengthening the skin barrier.5,6,7 A well formulated product containing AHAs, PHAs, Formulation Component Ingredients Benefits for Problem Dry Skin ­ PDS Cream was better and faster at 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic and BAs can normalize epidermal thickness, restore normal stratum corneum barrier descaling psoriatic plaques and improving function, and promote better water retention. acids and their topical actions. In Baran R and Maibach HI, editors: disease severity than a prescription Psoriatic Plaque on the Left Knee Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, descaling cream containing 6% salicylic – Exfoliation 2005, Taylor & Francis Group. A high-strength, cosmetically elegant skincare cream containing a 20% 15% blend of glycolic acid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) – NormalizationBefore of epidermalAfter 3 weeks 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and address the challenge of problem dry skin conditions. This posterAlpha reviews hydroxy acids acid, lactic acid, and (once-a-day application) related compounds: topical treatment of ichthyotic disorders. Arch ­ the effects of this high strength AHA/PHA/BA cream on the clinical and stratum corneum PDS Cream is a highly effective, Dermatol. 1974;110:586-590. PDS Cream improves dry, flakymandelic winter skin acidwith 2 applications. Dry and scaly heels become soft and smooth after cosmetically elegant topical treatment presentation of common dry skin conditions including winter xerosis and thicknessan overnight application of PDS Cream for 3 weeks. 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hyperkeratosis of the heels as well as more severe hyperkeratotic for a range of common as well as less common mild to severe dry skin hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. conditions such as psoriasis vulgaris and lamellar ichthyosis. 1997 Dec;137(6):934-8. Lamellar Ichthyosis 5% blend of – LightPsoriasis exfoliation Vulgaris conditions seen in dermatological Poly hydroxy / practice. 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, Test Product PDS Cream twice daily for 2 weeksgluconolactone with significant improvement and in the – Moisturizationmoderate plaque psoriasis used PDS Cream and 6% salicylic acid cream bionic acids ® Elsevier, Inc. appearance and texture of the treatedmaltobionic skin. The stratum coracidneum showed – Skin(Salex barrier(6% Salicylic strAcid)engthening Cream, Coria Laboratories, Ltd., Forth Worth, PDS Cream reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice References 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful ® (Problem Dry Skin Cream, NeoStrata Company, Inc, Princeton, NJ, USA) daily for 2 weeks.8 At the end of therapy, PDS Cream reduced scaling and yet gentle skincare ingredient with multiple benefits to protect skin and Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. reverse the visible signs of aging. Poster presented at the Summer – Antioxidant 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry Academy Meeting of the American Academy of Dermatology, Chicago, IL, Vitamin E Tocopheryl acetate skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin – Emollient 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic August 4-8, 2010. Psoriatic Plaque on the Left Knee acids and their topical actions. In Baran R and Maibach HI, editors: Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, – Exfoliation 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly Alpha hydroxy acids acid, lactic acid, and and stratum corneum – Reduction in skin roughness related compounds: topical treatment of ichthyotic disorders. Arch hydroxy acid cream to reduce scaling of lesions associated with moderate, mandelic acid Dermatol. 1974;110:586-590. thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of Emollient/occlusive 20% blend of and dryness on contact hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. 1997 Dec;137(6):934-8. the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. 5% blend of – Light exfoliation Poly hydroxy / vehicle oils and beeswax – Long-lasting feeling 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, Before After 2 weeks bionic acids Elsevier, Inc. maltobionic acid – Skin barrier strengthening of moisturization 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful (twice-a-day application) yet gentle skincare ingredient with multiple benefits to protect skin and – Antioxidant reverse the visible signs of aging. Poster presented at the Summer Vitamin E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology, Chicago, IL, – Emollient August 4-8, 2010.After 2 weeks (twice-a-day application) – Enhanced product mildness 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, Amphoteric Agent Arginine bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness and gentle delivery of AHAs hydroxyPDS acid cream Cr to reduceeam scaling exfoliates, of lesions associated with moderate,hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of Emollient/occlusive 20% blend of and dryness on contact chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of the Americanthe Academy hyperkeratotic of Dermatology, Miami, FL, March skin 5 – 9, 2010. of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks Poster exhibit at the 69th Annual Meeting of the American Academy of of moisturization (twice-a-day application) Dermatology, New Orleans, LA, February 4-8, 2011. P1619

After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Dermatology, New Orleans, LA, February 4-8, 2011. P1619 20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis

20% Alpha/Poly Hydroxy Acid Cream IrinaImpr Brovesouda, the BrSymptomsenda L. Edison,of Recalcitrant Barbara Hyperkeratosis A. Green Irina Brouda, BrendaNeoStrata L. Edison, Barbara Company A. Green , Inc., Princeton, NJ, USA NeoStrata Company, Inc., Princeton, NJ, USA

Introduction Clinical Studies Summary

Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic Introduction ClinicalPDS Cream Studieswas tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight Summary marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, Winter Xerosis Heel Hyperkeratosisgluconolactone, and maltobionic acid, Hyperkeratinization, a thickening of the stratum corneum,cracked, is flaky a, and well-documented itchy skin, which can be both uncomfortable and embarrassing.1 Winter Xerosis on the Leg Severe Hyperkeratosis of the Heel ­ PDS Cream contains a carefully selected Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis.in severe dry skin conditions. These2 disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female­ PDS volunteer Cream markedly treated improved hyperkeratotic the heels with an overnight marked by increased corneocyte cohesion, decreasedAlpha rates hydroxy of acids desquamation, (AHAs), poly hydroxy acids (PHAs), low and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 hydroxy acids, including glycolic acid, have a profound effect on stratum corneum barrier function. Select AHAs reducein the appearance and texture of treated skin was apparent after just applicationthickened of PDS skin of Cr winteream xer osis,for 3heel weeks. Hyperkeratosis was completely surface lipid content, and poor water retention in the stratumcorneocyte cohesion cor andneum. promote desquamationIndividuals and have been shown to significantly hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization havehyperkeratosis, unusually and X-linked ichthyosis. dry, r4 ough,PHAs and BAs are hygroscopic substances in case studies. that reduce transepidermal water loss and protect against exter1 nal insults by gluconolactone, and maltobionic acid, cracked, flaky, and itchy skin, which can be both uncomfortablestrengthening the skin and barrier .5,6,7embarrassing.A well formulated product containing AHAs, PHAs, Winter Xerosis on the Leg ­ PDS Cream wasSever better ande fasterHyperkeratosis at of the Heel and BAs can normalize epidermal thickness, restore normal stratum corneum barrier descaling psoriatic plaques and improving in a highly emollient vehicle. Over-the-counter moisturizers are helpful for mild xerosisfunction, but and pr haveomote better limited water retention. effectiveness disease severity than a prescription in severe dry skin conditions.2 descaling cream containing 6% salicylic A high-strength, cosmetically elegant skincare cream containing a 20% acid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks address the challenge of problem dry skin conditions. This poster reviews (once-a-day application) ­ PDS Cream markedly improved the the effects of this high strength AHA/PHA/BA cream on the clinical ­ PDS Cream is a highly effective, Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after presentation of common dry skin conditions including winter xerosis and cosmetically elegant topical treatment clinical appearance and feel of dry scaly 3 an overnight application of PDS Cream for 3 weeks. have a profound effect on stratum corneum barrier function.hyperkeratosisSelect of the heels AHAs as well raseduce more severe hyperkeratotic for a range of common as well as conditions such as psoriasis vulgaris and lamellar ichthyosis. less common mild to severe dry skin thickened skin of winter xerosis, heel corneocyte cohesion and promote desquamation and have been shown to significantly Lamellar Ichthyosis Psoriasis Vulgaris conditions seen in dermatological practice. An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellarTest Product ichthyosis, epidermolytic PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaque psoriasis used PDS Cream and 6% salicylic acid cream 4 appearance and texture of the treated skin. The stratum corneum showed (Salex® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, in case studies. hyperkeratosis, and X-linked ichthyosis. PHAs and BAsPDS Crareame hygroscopic substances reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice References (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton, NJ, USA) daily for 2 weeks.8 At the end of therapy, PDS Cream reduced scaling and that reduce transepidermal water loss and protect against external insults by Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. 5,6,7 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry strengthening the skin barrier. A well formulated product containing AHAs, PHAs, skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. ­ Formulation Component Ingredients Benefits for Problem Dry Skin 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic PDS Cream was better and faster at Psoriatic Plaque on the Left Knee acids and their topical actions. In Baran R and Maibach HI, editors: and BAs can normalize epidermal thickness, restore normal stratum corneum barrier Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation descaling psoriatic plaques and improving 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Alpha hydroxy acids acid, lactic acid, and function, and promote better water retention. and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch mandelic acid Dermatol. 1974;110:586-590. disease severity than a prescription thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. 1997 Dec;137(6):934-8. descaling cream containing 6% salicylic 5% blend of – Light exfoliation Poly hydroxy / 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy A high-strength, cosmetically elegant skincare cream containinggluconolactone and a 20%– Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, bionic acids Elsevier, Inc. acid in a controlled clinical trial. maltobionic acid – Skin barrier strengthening 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before yet gentle skincare ingredient with multiple benefits to protect skin and After 3 weeks – Antioxidant reverse the visible signs of aging. Poster presented at the Summer Vitamin E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology, Chicago, IL, address the challenge of problem dry skin conditions. This poster reviews– Emollient August 4-8, 2010. (once-a-day application) 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly ­ PDS Cream is a highly effective, the effects of this high strength AHA/PHA/BA cream on the clinical – Reduction in skin roughness hydroxy acid cream to reduce scaling of lesions associated with moderate, Emollient/occlusive 20% blend of and dryness on contact PDS Cream improves dry, flaky winter skin with 2 applications. chrDryonic plaque andpsoriasis. Poster scaly presented at theheels 68th Annual Meeting become of soft and smooth after the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. cosmetically elegant topical treatment presentation of common dry skin conditions includingvehicle winteroils and beeswaxxerosis– Long-lasting and feeling Before After 2 weeks an overnight application of PDS Cream for 3 weeks. of moisturization (twice-a-day application) for a range of common as well as After 2 weeks (twice-a-day application) hyperkeratosis of the heels as well as more severe hyperkeratotic – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of less common mild to severe dry skin conditions such as psoriasis vulgaris and lamellar ichthyosis. the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Lamellar Ichthyosis PsoriasisDermatology , NewV Orleans,ulgaris LA, February 4-8, 2011. P1619 conditions seen in dermatological practice. An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with Test Product PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaque psoriasis used PDS Cream and 6% salicylic acid cream appearance and texture of the treated skin. The stratum corneum showed (Salex® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, PDS Cream reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice References (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton, NJ, USA) daily for 2 weeks.8 At the end of therapy, PDS Cream reduced scaling and Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic acids and their topical actions. In Baran R and Maibach HI, editors: Psoriatic Plaque on the Left Knee Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Alpha hydroxy acids acid, lactic acid, and and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch mandelic acid Dermatol. 1974;110:586-590. thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. 1997 Dec;137(6):934-8. 5% blend of – Light exfoliation Poly hydroxy / 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, bionic acids Elsevier, Inc. maltobionic acid – Skin barrier strengthening 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful yet gentle skincare ingredient with multiple benefits to protect skin and – Antioxidant reverse the visible signs of aging. Poster presented at the Summer Vitamin E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology, Chicago, IL, – Emollient August 4-8, 2010. 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness hydroxy acid cream to reduce scaling of lesions associated with moderate, chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of Emollient/occlusive 20% blend of and dryness on contact the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks of moisturization (twice-a-day application)

After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Dermatology, New Orleans, LA, February 4-8, 2011. P1619 20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis

Irina Brouda, Brenda 20%L. Edison, Alpha/Poly Barbara Hydr A.oxy Gr Acideen Cream Improves the Symptoms of Recalcitrant Hyperkeratosis NeoStrata Company, Inc., Princeton, NJ, USA Irina Brouda, Brenda L. Edison, Barbara A. Green NeoStrata Company, Inc., Princeton, NJ, USA

Introduction Clinical Studies Summary

Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic Introduction Clinical Studies PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight Summary marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, Winter Xerosis Heel Hyperkeratosis gluconolactone, and maltobionic acid, Hyperkeratinization, a thickening of the stratum corneum, is a well-documented cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.1 Winter Xerosis on the Leg Severe Hyperkeratosis of the Heel ­ PDS Cream contains a carefully selected Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are in severe dry skin conditions.2 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight ­ PDS Cream markedly improved the marked by increased corneocyte cohesion, decreased rates of desquamation, low Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 hydroxy acids, including glycolic acid, in the appearance and texture of treatedhave skin a pr ofoundwas ef apparfect on stratument corafterneum barrierjust function. Select AHAs reduceapplication of PDS Cream for 3 weeks. Hyperkeratosis was completely thickened skin of winter xerosis, heel surface lipid content, and poor water retention in the stratum corneum. Individuals corneocyte cohesion and promote desquamation and have been shown to significantly hyperkeratosis, and lamellar ichthyosis 2 applications in 24 hours in this female imprvolunteerove severe hyperkeratotic. conditions, including lamellar ichthyosis, epidermolyticresolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, hyperkeratosis, and X-linked ichthyosis.4 PHAs and BAs are hygroscopic substances in case studies. 1 that reduce transepidermal water loss and protect against external insults by gluconolactone, and maltobionic acid, cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing. Winter Xerosisstr onengthening the the Leg skin barrier.5,6,7 A well formulated product containing AHAs, PHAs, Severe Hyperkeratosis of the Heel ­ PDS Cream was better and faster at and BAs can normalize epidermal thickness, restore normal stratum corneum barrier in a highlydescaling psoriatic emollient plaques and vehicle. improving Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness function, and promote better water retention. disease severity than a prescription in severe dry skin conditions.2 descaling cream containing 6% salicylic A high-strength, cosmetically elegant skincare cream containing a 20% acid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks address the challenge of problem dry skin conditions. This poster reviews (once-a-day application) ­ PDS Cream markedly improved the the effects of this high strength AHA/PHA/BA cream on the clinical ­ PDS Cream is a highly effective, Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after presentation of common dry skin conditions including winter xerosis and clinicalcosmetically appearance elegant topical tr eatmentand feel of dry scaly 3 an overnight application of PDS Cream for 3 weeks. have a profound effect on stratum corneum barrier function. Select AHAs reduce hyperkeratosis of the heels as well as more severe hyperkeratotic for a range of common as well as conditions such as psoriasis vulgaris and lamellar ichthyosis. thickenedless common skin mild to ofsever wintere dry skin xerosis, heel corneocyte cohesion and promote desquamation and have been shown to significantly Lamellar Ichthyosis Psoriasis Vulgaris conditions seen in dermatological practice. An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic Test Product PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaque psoriasis used PDS Cream and 6% salicylic acid cream 4 appearance and texture of the treated skin. The stratum corneum showed (Salex® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, in case studies. hyperkeratosis, and X-linked ichthyosis. PHAs and BAs are hygroscopic substances PDS Cream reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice References (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton, NJ, USA) daily for 2 weeks.8 At the end of therapy, PDS Cream reduced scaling and that reduce transepidermal water loss and protect against external insults by Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. 5,6,7 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry strengthening the skin barrier. A well formulated product containing AHAs, PHAs, ­ skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin PDS3. VanCr Scott eamEJ and Yu RJ. α -Hydrwasoxyacids, polyhydrbetteroxy acids, aldobionic and faster at Psoriatic Plaque on the Left Knee acids and their topical actions. In Baran R and Maibach HI, editors: and BAs can normalize epidermal thickness, restore normal stratum corneum barrier Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation descaling psoriatic plaques and improving 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Alpha hydroxy acids acid, lactic acid, and function, and promote better water retention. and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch mandelic acid diseaseDermatol. 1974;110:586-590. severity than a prescription thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. descaling1997 Dec;137(6):934-8. cream containing 6% salicylic 5% blend of – Light exfoliation Poly hydroxy / 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy A high-strength, cosmetically elegant skincare cream containing a 20% gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, bionic acids acid Elsevierin , Inc.a controlled clinical trial. maltobionic acid – Skin barrier strengthening 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks yet gentle skincare ingredient with multiple benefits to protect skin and – Antioxidant reverse the visible signs of aging. Poster presented at the Summer Vitamin E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology, Chicago, IL, address the challenge of problem dry skin conditions. This poster reviews – Emollient (once-a-day application) August 4-8, 2010. 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, ­ PDS bilateralCr comparisoneam of topical is 6% salicylica highly acid cream and 20% alpha/polyeffective, the effects of this high strength AHA/PHA/BA cream on the clinical – Reduction in skin roughness hydroxy acid cream to reduce scaling of lesions associated with moderate, PDS Cream improves dry, flaky winterEmollient/occlusive skin with20% 2 blendapplications. of and dryness on contact Dry and scaly heels become soft and smooth after chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of cosmeticallythe American Academy of Dermatology elegant, Miami, FL, March 5topical – 9, 2010. treatment presentation of common dry skin conditions including winter xerosis and vehicle oils and beeswax – Long-lasting feeling an overnight application of PDS CreamBefore for 3 weeks. After 2 weeks of moisturization (twice-a-day application) for a range of common as well as After 2 weeks (twice-a-day application) hyperkeratosis of the heels as well as more severe hyperkeratotic – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of less common mild to severe dry skin conditions such as psoriasis vulgaris and lamellar ichthyosis. the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Lamellar Ichthyosis Psoriasis Vulgaris conditionsDermatology, New Orleans, LA, Februaryseen 4-8, 2011. in dermatologicalP1619 practice. An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with Test Product PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaque psoriasis used PDS Cream and 6% salicylic acid cream appearance and texture of the treated skin. The stratum corneum showed (Salex® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, PDS Cream reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice References (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton, NJ, USA) daily for 2 weeks.8 At the end of therapy, PDS Cream reduced scaling and Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic acids and their topical actions. In Baran R and Maibach HI, editors: Psoriatic Plaque on the Left Knee Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Alpha hydroxy acids acid, lactic acid, and and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch mandelic acid Dermatol. 1974;110:586-590. thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. 1997 Dec;137(6):934-8. 5% blend of – Light exfoliation Poly hydroxy / 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, bionic acids Elsevier, Inc. maltobionic acid – Skin barrier strengthening 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful yet gentle skincare ingredient with multiple benefits to protect skin and – Antioxidant reverse the visible signs of aging. Poster presented at the Summer Vitamin E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology, Chicago, IL, – Emollient August 4-8, 2010. 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness hydroxy acid cream to reduce scaling of lesions associated with moderate, chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of Emollient/occlusive 20% blend of and dryness on contact the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks of moisturization (twice-a-day application)

After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Dermatology, New Orleans, LA, February 4-8, 2011. P1619 20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis

Irina Brouda, Brenda L. Edison, Barbara A. Green NeoStrata Company, Inc., Princeton, NJ, USA

Introduction Clinical Studies Summary

Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, gluconolactone, and maltobionic acid, cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.1 Winter Xerosis on the Leg Severe Hyperkeratosis of the Heel Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. in severe dry skin conditions.2 ­ PDS Cream markedly improved the Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 have a profound effect on stratum corneum barrier function. Select AHAs reduce thickened skin of winter xerosis, heel corneocyte cohesion and promote desquamation and have been shown to significantly hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic hyperkeratosis, and X-linked ichthyosis.4 PHAs and BAs are hygroscopic substances in case studies. that reduce transepidermal water loss and protect against external insults by strengthening the skin barrier.5,6,7 A well formulated product containing AHAs, PHAs, ­ PDS Cream was better and faster at and BAs can normalize epidermal thickness, restore normal stratum corneum barrier descaling psoriatic plaques and improving function, and promote better water retention. disease severity than a prescription descaling cream containing 6% salicylic A high-strength, cosmetically elegant skincare cream containing20% Alpha/Poly a 20% Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis acid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks Irina Brouda, Brenda L. Edison, Barbara A. Green address the challenge of problem dry skin conditions. This poster reviews NeoStrata Company, Inc., Princeton, NJ, USA (once-a-day application) the effects of this high strength AHA/PHA/BA cream on the clinical ­ PDS Cream is a highly effective, PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after cosmetically elegant topical treatment presentation of common dry skin conditions includingIntroduction winter xerosis and Clinical Studies Summaran overy night application of PDS Cream for 3 weeks. Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected for a range of common as well as hyperkeratosis of the heels as well as more seversymptom eof xerhyperkeratoticosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, less common mild to severe dry skin surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely conditions such as psoriasis vulgaris and lamellar ichthyosis. 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, 1 gluconolactone, and maltobionic acid, conditions seen in dermatological cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.Lamellar IchthyosisWinter Xerosis on the Leg Severe Hyperkeratosis of the Heel Psoriasis Vulgaris Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. in severe dry skin conditions.2 practice. An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized,­ PDS Cream markedly double-blind, improved the bilateral clinical trial, 24 adults with Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 Test Product have a profound effect on stratum corneum barrier function. Select AHAs reducePDS Cream twice daily for 2 weeks with significant improvement in the moderatethickened plaque skin psoriasis of winter xerosis, used heel PDS Cream and 6% salicylic acid cream corneocyte cohesion and promote desquamation and have been shown to significantly ® hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolyticappearance and texture of the treated skin. The stratum corneum showed (Salex (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, PDS Cream hyperkeratosis, and X-linked ichthyosis.4 PHAs and BAs are hygroscopic substances in case studies. that reduce transepidermal water loss and protect against external insults by reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice References (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton,strengthening the skin NJ, barrier .USA)5,6,7 A well formulated product containing AHAs, PHAs, daily for­ PDS2 weeks. Cream was8 Atbetter the and end faster of at therapy, PDS Cream reduced scaling and and BAs can normalize epidermal thickness, restore normal stratum corneum barrier descaling psoriatic plaques and improving function, and promote better water retention. Skin Affected by Lamellar Ichthyosis improveddisease overall severity psoriasis than a prescription severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J descaling cream containing 6% salicylic Clin Dermatol. 2004;5(1):17-29. Key Benefit IngredientsA high-strength, cosmetically elegant skincare cream containing a 20% salicylic acidacid in acr contream.olled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry address the challenge of problem dry skin conditions. This poster reviews (once-a-day application) skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. the effects of this high strength AHA/PHA/BA cream on the clinical ­ PDS Cream is a highly effective, Formulation Component Ingredients Benefits for Problem Dry Skin PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after cosmetically elegant topical treatment 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic presentation of common dry skin conditions including winter xerosis and an overnight application of PDS Cream for 3 weeks. hyperkeratosis of the heels as well as more severe hyperkeratotic for a range of commonPsoriatic as well as Plaque on the Left Knee acids and their topical actions. In Baran R and Maibach HI, editors: conditions such as psoriasis vulgaris and lamellar ichthyosis. less common mild to severe dry skin Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation Lamellar Ichthyosis Psoriasis Vulgaris conditions seen in dermatological 2005, Taylor & Francis Group. 15% blend of glycolic practice. – Normalization of epidermal An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Test Product PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaque psoriasis used PDS Cream and 6% salicylic acid cream Alpha hydroxy acids acid, lactic acid, and appearance and texture of the treated skin. The stratum corneum showed (Salex® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, related compounds: topical treatment of ichthyotic disorders. Arch PDSand Cream stratum corneum reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twice References Dermatol. 1974;110:586-590. mandelic acid (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton, NJ, USA) daily for 2 weeks.8 At the end of therapy, PDS Cream reduced scaling and thickness Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic 1997 Dec;137(6):934-8. Psoriatic Plaque on the Left Knee acids and their topical actions. In Baran R and Maibach HI, editors: 5% blend of – Light exfoliation Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy Poly hydroxy / 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal Before 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and gluconolactone and –AlphaMoisturization hydroxy acids acid, lactic acid, and acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch bionic acids mandelic acid Dermatol. 1974;110:586-590. Elsevier, Inc. maltobionic acid – Skin barrier strengthening thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful 1997 Dec;137(6):934-8. 5% blend of – Light exfoliation Poly hydroxy / 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy yet gentle skincare ingredient with multiple benefits to protect skin and gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, bionic acids Elsevier, Inc. maltobionic acid – Skin barrier strengthening reverse the visible signs of aging. Poster presented at the Summer – Antioxidant 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful yet gentle skincare ingredient with multiple benefits to protect skin and Academy Meeting of the American Academy of Dermatology, Chicago, IL, Vitamin E Tocopheryl acetate reverse the visible signs of aging. Poster presented at the Summer – Antioxidant –VitaminEmollient E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology, Chicago, IL, August 4-8, 2010. – Emollient August 4-8, 2010. 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness hydroxy acid cream to reduce scaling of lesions associated with moderate, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly Emollient/occlusive 20% blend of and dryness on contact chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of – Reduction in skin roughness the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. hydroxy acid cream to reduce scaling of lesions associated with moderate, vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks of moisturization (twice-a-day application) chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of Emollient/occlusive 20% blend of and dryness on contact the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine vehicle oils and beeswax – Long-lasting feeling and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity ofBefore After 2 weeks the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of of moisturization Dermatology, New Orleans, LA, February 4-8, 2011. P1619 (twice-a-day application)

After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Dermatology, New Orleans, LA, February 4-8, 2011. P1619 20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis

Irina Brouda, Brenda L. Edison, Barbara A. Green NeoStrata Company, Inc., Princeton, NJ, USA

Introduction Clinical Studies Summary

Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, gluconolactone, and maltobionic acid, cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.1 Winter Xerosis on the Leg Severe Hyperkeratosis of the Heel Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. in severe dry skin conditions.2 ­ PDS Cream markedly improved the Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 have a profound effect on stratum corneum barrier function. Select AHAs reduce thickened skin of winter xerosis, heel corneocyte cohesion and promote desquamation and have been shown to significantly hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic hyperkeratosis, and X-linked ichthyosis.4 PHAs and BAs are hygroscopic substances in case studies. that reduce transepidermal water loss and protect against external insults by strengthening the skin barrier.5,6,7 A well formulated product containing AHAs, PHAs, ­ PDS Cream was better and faster at and BAs can normalize epidermal thickness, restore normal stratum corneum barrier descaling psoriatic plaques and improving function, and promote better water retention. disease severity than a prescription descaling cream containing 6% salicylic A high-strength, cosmetically elegant skincare cream containing a 20% 20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosisacid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks Irina Brouda, Brenda L. Edison, Barbara A. Green address the challenge of problem dry skin conditions. This poster reviews NeoStrata Company, Inc.,(once-a-day Princeton, NJ, USA application) the effects of this high strength AHA/PHA/BA cream on the clinical ­ PDS Cream is a highly effective, PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after cosmetically elegant topical treatment presentation of common dry skin conditions including winter xerosis and Introduction Clinicalan over Studiesnight application of PDS Cream for 3 weeks. Summary Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis for ­a PDS range Cream contains of common a carefully selected as well as hyperkeratosis of the heels as well as more severe hyperkeratotic symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight marked by increased corneocyte cohesion, decreased rates of desquamation, low less hydrcommonoxy acids, including mild glycolic to acid,severe dry skin surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely conditions such as psoriasis vulgaris and lamellar ichthyosis. 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, 1 conditionsgluconolactone, seen and maltobionic in dermatological acid, Lamellar Ichthyosis cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.Psoriasis VulgarisWinter Xerosis on the Leg Severe Hyperkeratosis of the Heel Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. in severe dry skin conditions.2 practice. An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with ­ PDS Cream markedly improved the Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 Test Product PDS Cream twice daily for 2 weeks withhave significant a profound effect impr on stratumovement corneum barrier in the function. Select AHAs reducemoderate plaque psoriasis used PDS Cream and 6% salicylic acid cream thickened skin of winter xerosis, heel corneocyte cohesion and promote desquamation and have been shown to significantly ® hyperkeratosis, and lamellar ichthyosis appearance and texture of the treated skin.improve The severe stratumhyperkeratotic cor conditions,neum including showed lamellar ichthyosis, epidermolytic(Salex (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, PDS Cream hyperkeratosis, and X-linked ichthyosis.4 PHAs and BAs are hygroscopic substances in case studies. reduced thickness and scaling and imprthatoved reduce hydration. transepidermal water loss and protect against external insults by TX, USA) to descale psoriatic plaques on opposite sides of the body twice References (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton, NJ, USA) strengthening the skin barrier.5,6,7 A well formulated product containing AHAs, PHAs,daily for 2 weeks.8 At the end of therapy, PDS Cream reduced scaling and ­ PDS Cream was better and faster at and BAs can normalize epidermal thickness, restore normal stratum corneum barrier descaling psoriatic plaques and improving Skin Affected by Lamellarfunction, and prIchthyosisomote better water retention. improved overall psoriasis severity significantly better and faster than 6% 1. Shwayderdisease T. Disor severityders ofthan keratinization: a prescription diagnosis and management. Am J Clin Dermatoldescaling. 2004;5(1):17-29. cream containing 6% salicylic Key Benefit Ingredients A high-strength, cosmetically elegant skincare cream containing a 20%salicylic acid cream. acid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry address the challenge of problem dry skin conditions. This poster reviews (once-a-day application) skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. the effects of this high strength AHA/PHA/BA cream on the clinical ­ PDS Cream is a highly effective, Formulation Component Ingredients Benefits for Problem Dry Skin PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after 3. Van Scottcosmetically EJ and Yu elegantRJ. α -Hydr topicaloxyacids, treatment polyhydroxy acids, aldobionic presentation of common dry skin conditions including winter xerosis and an overnight application of PDS Cream for 3 weeks. hyperkeratosis of the heels as well as more severe hyperkeratotic Psoriatic Plaque on the Left Knee acids andfor their a range topical of common actions. as In well Baran as R and Maibach HI, editors: conditions such as psoriasis vulgaris and lamellar ichthyosis. Textbookless of Cosmetic common mild Dermatology to severe dry, 3rd skin Edition, London and New York, – Exfoliation Lamellar Ichthyosis Psoriasis Vulgaris 2005, Taylorconditions & Francis seen Gr in oup.dermatological 15% blend of glycolic practice. – Normalization of epidermal An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Test Product PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaque psoriasis used PDS Cream and 6% salicylic acid cream Alpha hydroxy acids acid, lactic acid, and appearance and texture of the treated skin. The stratum corneum showed (Salex® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, related compounds: topical treatment of ichthyotic disorders. Arch and stratum corneum PDS Cream reduced thickness and scaling and improved hydration. TX, USA) to descale psoriatic plaques on opposite sides of the body twiceDermatolRefer. 1974;110:586-590.ences mandelic acid (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton, NJ, USA) daily for 2 weeks.8 At the end of therapy, PDS Cream reduced scaling and thickness Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than5. 6%Berardesca1. Shwayder E, T. DistanteDisorders of keratinization: F, Vignoli diagnosis GP and management., Oresajo Am JC, Green B. Alpha Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. hydroxyacids2. Lodén M. Rolemodulate of topical emollients stratum and moisturizers cor inneum the treatment barrier of dry function. Br J Dermatol. skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin 1997 Dec;137(6):934-8.3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic Psoriatic Plaque on the Left Knee acids and their topical actions. In Baran R and Maibach HI, editors: 5% blend of – Light exfoliation Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy Poly hydroxy / 15% blend of glycolic 2005, Taylor & Francis Group. Before – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and gluconolactone and – Moisturization Alpha hydroxy acids acid, lactic acid, and acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch bionic acids mandelic acid Elsevier, DermatolInc. . 1974;110:586-590. maltobionic acid – Skin barrier strengthening thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha 7. Brouda I,hydr Edisonoxyacids modulate BL, stratum Weinkauf corneum barrier RL, function. Gr Breen J Dermatol BA.. Maltobionic acid, a powerful 1997 Dec;137(6):934-8. 5% blend of – Light exfoliation Poly hydroxy / yet gentle6. Green skincar BA and Bridene ME.ingr PHAsedient and bionic withacids: Next multiple generation hydr benefitsoxy to protect skin and gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, bionic acids Elsevier, Inc. maltobionic acid – Skin barrier strengthening reverse the visible signs of aging. Poster presented at the Summer – Antioxidant 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful Academyyet Meetinggentle skincare ingr ofedient the with American multiple benefits to Academy protect skin and of Dermatology, Chicago, IL, Vitamin E Tocopheryl acetate reverse the visible signs of aging. Poster presented at the Summer – Antioxidant – Emollient Vitamin E Tocopheryl acetate August 4-8,Academy 2010. Meeting of the American Academy of Dermatology, Chicago, IL, – Emollient August 4-8, 2010. 8. Green 8.BA,Green Edison BA, Edison BL, BL, Clark ClarkAR, Feldman AR, SR. Double-blind, Feldman randomized, SR. Double-blind, randomized, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness bilateral hydrcomparisonoxy acid cream to reduce of topicalscaling of lesions 6% associated salicylic with moderate, acid cream and 20% alpha/poly Emollient/occlusive 20% blend of and dryness on contact chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of – Reduction in skin roughness hydroxy theacid American cr Academyeam ofto Dermatology reduce, Miami, scaling FL, March 5of – 9, 2010.lesions associated with moderate, vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks of moisturization (twice-a-day application) chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of Emollient/occlusive 20% blend of and dryness on contact the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine vehicle oils and beeswax – Long-lasting feeling and gentle delivery of AHAsBefore PDS Cream exfoliates, hydrates, and smoothesAfter 2 weeksPDS Cream reduces scaling and improves overall severity of the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of of moisturization (twice-a-day application) Dermatology, New Orleans, LA, February 4-8, 2011. P1619

After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Dermatology, New Orleans, LA, February 4-8, 2011. P1619 20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis 20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant HyperkeratosisIrina Brouda, Brenda L. Edison, Barbara A. Green NeoStrata Company, Inc., Princeton, NJ, USA Irina Brouda, Brenda L. Edison, Barbara A. Green NeoStrata Company, Inc., Princeton, NJ, USA Introduction Clinical Studies Summary Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, gluconolactone, and maltobionic acid, Introduction Clinical Studies cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.1 SummarWinter Xerosisy on the Leg Severe Hyperkeratosis of the Heel Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel inHyperkeratosis severe dry skin conditions.2 ­ PDS Cream contains a carefully selected ­ PDS Cream markedly improved the symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A femalehave volunteera profound ef trfecteated on stratum hyperkeratotic corneum barrier heels function. withSelect an AHAsover nightreduce thickened skin of winter xerosis, heel marked by increased corneocyte cohesion, decreased rates of desquamation, low corneocyte cohesion and promote desquamation and have been shown to significantly in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely hydroxy acids, including glycolic acid, hyperkeratosis, and lamellar ichthyosis surface lipid content, and poor water retention in the stratum corneum. Individuals improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. 4 lactic acid, mandelic acid, in case studies. suffering from severe disorders of hyperkeratinization have unusually dry, rough, hyperkeratosis, and X-linked ichthyosis. PHAs and BAs are hygroscopic substances that reduce transepidermal water loss and protect against external insults by gluconolactone, and maltobionic acid, cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.1 Winter Xerosis on the Leg strengthening theSever skin barriere Hyperkeratosis.5,6,7 A well formulated pr oductof the containing Heel AHAs, PHAs, ­ PDS Cream was better and faster at Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness and BAs can normalize epidermal thickness, restore normal stratum corneum barrier in a highly emollient vehicle. descaling psoriatic plaques and improving function, and promote better water retention. disease severity than a prescription 2 in severe dry skin conditions. descaling cream containing 6% salicylic A high-strength, cosmetically elegant skincare cream containing a 20% acid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before ­ PDS CreamAfter markedly 24 hours (2 applications) improved theBefore After 3 weeks Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) address the challenge of problem dry skin conditions. This poster reviews clinical appearance and feel of dry scaly (once-a-day application) 3 the effects of this high strength AHA/PHA/BA cream on the clinical ­ PDS Cream is a highly effective, have a profound effect on stratum corneum barrier function. Select AHAs reduce PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after cosmetically elegant topical treatment presentation of common dry skin conditions including winter xerosis and thickened skin of winter xerosis, heelan overnight application of PDS Cream for 3 weeks. corneocyte cohesion and promote desquamation and have been shown to significantly for a range of common as well as hyperkeratosis of the heels as well as more severe hyperkeratotic hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic conditions such as psoriasis vulgaris and lamellar ichthyosis. less common mild to severe dry skin conditions seen in dermatological 4 Lamellar Ichthyosisin case studies. Psoriasis Vulgaris hyperkeratosis, and X-linked ichthyosis. PHAs and BAs are hygroscopic substances practice. An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with that reduce transepidermal water loss and protect against external insults by Test Product PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaque psoriasis used PDS Cream and 6% salicylic acid cream strengthening the skin barrier.5,6,7 A well formulated product containing AHAs, PHAs, appearance and texture of the treated skin. The stratum corneum showed (Salex® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, PDS Cream reduced thickness­ PDSand scaling Cr andeam improved was hydration. better and fasterTX, USA)at to descale psoriatic plaques on opposite sides of the body twice References and BAs can normalize epidermal thickness, restore normal stratum corneum barrier (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton, NJ, USA) descaling psoriatic plaques and dailyimpr for 2oving weeks.8 At the end of therapy, PDS Cream reduced scaling and Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J function, and promote better water retention. Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. disease severity than a prescription 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin descaling cream containing 6% salicylic 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic Psoriatic Plaque on the Left Knee acids and their topical actions. In Baran R and Maibach HI, editors: A high-strength, cosmetically elegant skincare cream containing a 20% Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation acid in a controlled clinical trial. 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) BeforAlphae hydroxy acids acid, lactic acid, Afterand 3 weeks and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch mandelic acid (once-a-day application) Dermatol. 1974;110:586-590. address the challenge of problem dry skin conditions. This poster reviews thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha ­ PDS Cream is a highly effective, hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. the effects of this high strength AHA/PHA/BA cream on the clinical 1997 Dec;137(6):934-8. PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels5% blend become of soft– Light and exfoliation smooth after Poly hydroxy / cosmetically elegant topical treatment 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, presentation of common dry skin conditions including winter xerosis and bionican acidsovernight application of PDS Cream for 3 weeks. Elsevier, Inc. maltobionic acid – Skin barrier strengthening for a range of common as well as 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful hyperkeratosis of the heels as well as more severe hyperkeratotic yet gentle skincare ingredient with multiple benefits to protect skin and – Antioxidant less common mild to severe dry skin reverse the visible signs of aging. Poster presented at the Summer conditions such as psoriasis vulgaris and lamellar ichthyosis. Vitamin E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology, Chicago, IL, – Emollient August 4-8, 2010. Lamellar Ichthyosis Psoriasis Vulgaris conditions seen in dermatological 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness practice. hydroxy acid cream to reduce scaling of lesions associated with moderate, Emollient/occlusive 20% blend of and dryness on contact chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks Test Product PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaque psoriasis used PDS Cream andof moisturization 6% salicylic acid cream (twice-a-day application) appearance and texture of the treated skin. The stratum corneum showed (Salex® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, After 2 weeks (twice-a-day application) – Enhanced product mildness PDS Cream reduced thickness and scaling and improved hydration. TX, USA)Amphoteric to descale Agent psoriaticArginine plaques on opposite sides of the body twice References PDS Cream reduces scaling and improves overall severity of ® 8 and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes (Problem Dry Skin Cream, NeoStrata Company, Inc, Princeton, NJ, USA) daily for 2 weeks. At the end of therapy, PDS Cream reduced scaling and the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Dermatology, New Orleans, LA, February 4-8, 2011. P1619 Key Benefit Ingredients salicylic acid cream. Clin Dermatol. 2004;5(1):17-29. 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic acids and their topical actions. In Baran R and Maibach HI, editors: Psoriatic Plaque on the Left Knee Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Alpha hydroxy acids acid, lactic acid, and and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch mandelic acid Dermatol. 1974;110:586-590. thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. 1997 Dec;137(6):934-8. 5% blend of – Light exfoliation Poly hydroxy / 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, bionic acids Elsevier, Inc. maltobionic acid – Skin barrier strengthening 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful yet gentle skincare ingredient with multiple benefits to protect skin and – Antioxidant reverse the visible signs of aging. Poster presented at the Summer Vitamin E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology, Chicago, IL, – Emollient August 4-8, 2010. 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness hydroxy acid cream to reduce scaling of lesions associated with moderate, chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of Emollient/occlusive 20% blend of and dryness on contact the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks of moisturization (twice-a-day application)

After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Dermatology, New Orleans, LA, February 4-8, 2011. P1619 20% Alpha/Poly Hydroxy Acid Cream Improves the Symptoms of Recalcitrant Hyperkeratosis

Irina Brouda, Brenda L. Edison, Barbara A. Green NeoStrata Company, Inc., Princeton, NJ, USA

Introduction Clinical Studies Summary

Hyperkeratinization, a thickening of the stratum corneum, is a well-documented Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected symptom of xerosis, keratosis pilaris, ichthyosis, and psoriasis. These disorders are 20% combination of alpha/poly/bionic PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight marked by increased corneocyte cohesion, decreased rates of desquamation, low hydroxy acids, including glycolic acid, surface lipid content, and poor water retention in the stratum corneum. Individuals in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, suffering from severe disorders of hyperkeratinization have unusually dry, rough, gluconolactone, and maltobionic acid, cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.1 Winter Xerosis on the Leg Severe Hyperkeratosis of the Heel Over-the-counter moisturizers are helpful for mild xerosis but have limited effectiveness in a highly emollient vehicle. in severe dry skin conditions.2 ­ PDS Cream markedly improved the Alpha hydroxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 have a profound effect on stratum corneum barrier function. Select AHAs reduce thickened skin of winter xerosis, heel corneocyte cohesion and promote desquamation and have been shown to significantly hyperkeratosis, and lamellar ichthyosis improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic hyperkeratosis, and X-linked ichthyosis.4 PHAs and BAs are hygroscopic substances in case studies. that reduce transepidermal water loss and protect against external insults by strengthening the skin barrier.5,6,7 A well formulated product containing AHAs, PHAs, ­ PDS Cream was better and faster at and BAs can normalize epidermal thickness, restore normal stratum corneum barrier descaling psoriatic plaques and improving function, and promote better water retention. disease severity than a prescription descaling cream containing 6% salicylic A high-strength, cosmetically elegant skincare cream containing a 20% acid in a controlled clinical trial. combination of alpha/poly/bionic hydroxy acids has been developed to Before After 24 hours (2 applications) Before After 3 weeks address the challenge of problem dry skin conditions. This poster reviews (once-a-day application) the effects of this high strength AHA/PHA/BA cream on the clinical ­ PDS Cream is a highly effective, PDS Cream improves dry, flaky winter skin with 2 applications. Dry and scaly heels become20% softAlpha/Poly and smooth afterHydr oxy Acid Crcosmeticallyeam Impr elegantoves topicalthe Symptoms treatment of Recalcitrant Hyperkeratosis presentation of common dry skin conditions including winter xerosis and an overnight application of PDS Cream for 3 weeks. for aIrina range Brouda, of Br commonenda L. Edison, as Barbara well A.as Gr een hyperkeratosis of the heels as well as more severe hyperkeratotic NeoStrata Company, Inc., Princeton, NJ, USA conditions such as psoriasis vulgaris and lamellar ichthyosis. less common mild to severe dry skin Lamellar Ichthyosis Psoriasis Vulgaris conditions seen in dermatological Introduction Clinical Studiespractice. Summary An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized,Hyperkeratinization, double-blind, a thickening bilateral of theclinical stratum trial,corneum, 24 is adultsa well-documented with Winter Xerosis Heel Hyperkeratosis ­ PDS Cream contains a carefully selected PDS Cream twice daily for 2 weeks with significant improvement in the moderate plaquesymptom psoriasis of xerosis, used keratosis PDS pilaris, Cream ichthyosis, and and 6% psoriasis. salicylic These aciddisorders cr areame 20% combination of alpha/poly/bionic Test Product marked by increased corneocyte cohesion, decreased rates of desquamation, low PDS Cream was tested on dry winter skin. Significant improvement A female volunteer treated hyperkeratotic heels with an overnight ® hydroxy acids, including glycolic acid, appearance and texture of the treated skin. The stratum corneum showed (Salex (6% Salicylicsurface lipidAcid) content, Cream, and poor Coria water rLaboratories,etention in the stratum Ltd., corneum. Forth Individuals Worth, in the appearance and texture of treated skin was apparent after just application of PDS Cream for 3 weeks. Hyperkeratosis was completely 2 applications in 24 hours in this female volunteer. resolved at the end of treatment. lactic acid, mandelic acid, PDS Cream reduced thickness and scaling and improved hydration. TX, USA) to descalesuffering psoriatic from severe plaquesdisorders of hyperkeratinizationon opposite sideshave unusually of the dry body, rough, twice cracked, flaky, and itchy skin, which can be both uncomfortable and embarrassing.1 References gluconolactone, and maltobionic acid, ® 8 Winter Xerosis on the Leg Severe Hyperkeratosis of the Heel (Problem Dry Skin Cream, NeoStrata Company, Inc, Princeton, NJ, USA) daily for 2 weeks.Over-the-counterAt the end moisturizers of therapy are helpful, PDS for mild Cr eamxerosis rbuteduced have limited scaling effectiveness and in a highly emollient vehicle. Skin Affected by Lamellar Ichthyosis improved overallin psoriasissevere dry skin severity conditions. 2significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Clin Dermatol. 2004;5(1):17-29. ­ PDS Cream markedly improved the Key Benefit Ingredients salicylic acid cream.Alpha hydr oxy acids (AHAs), poly hydroxy acids (PHAs), and aldobionic acids (BAs) clinical appearance and feel of dry scaly 3 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry have a profound effect on stratum corneum barrier function. Select AHAs reduce thickened skin of winter xerosis, heel corneocyte cohesion and promote desquamation and have been shown to significantly skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. hyperkeratosis, and lamellar ichthyosis Formulation Component Ingredients Benefits for Problem Dry Skin improve severe hyperkeratotic conditions, including lamellar ichthyosis, epidermolytic 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic 4 in case studies. hyperkeratosis, and X-linked ichthyosis. PHAs and BAs are hygroscopic substances acids and their topical actions. In Baran R and Maibach HI, editors: that reduce transepidermal water loss and protect against external insults by Psoriatic Plaque on the Left Knee Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, strengthening the skin barrier.5,6,7 A well formulated product containing AHAs, PHAs, ­ – Exfoliation 2005, Taylor & Francis Group. PDS Cream was better and faster at 15% blend of glycolic and BAs can normalize epidermal thickness, restore normal stratum corneum barrier descaling psoriatic plaques and improving – Normalization of epidermal function, and promote better water retention. 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Alpha hydroxy acids acid, lactic acid, and disease severity than a prescription and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch descaling cream containing 6% salicylic mandelic acid A high-strength, cosmetically elegant skincare cream containing a 20% Dermatol. 1974;110:586-590. acid in a controlled clinical trial. thickness combination of alpha/poly/bionic hydroxy acids has been developed to Before 5. Berardesca E, DistanteAfter F, 24 V hoursignoli (2 GPapplications), Oresajo C, Green B.Befor Alphae After 3 weeks address the challenge of problem dry skin conditions. This poster reviews hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. (once-a-day application) the effects of this high strength AHA/PHA/BA cream on the clinical ­ PDS Cream is a highly effective, PDS Cream1997 impr ovesDec;137(6):934-8. dry, flaky winter skin with 2 applications. Dry and scaly heels become soft and smooth after cosmetically elegant topical treatment presentation of common dry skin conditions including winter xerosis and an overnight application of PDS Cream for 3 weeks. 5% blend of – Light exfoliation 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy for a range of common as well as Poly hydroxy / Before hyperkeratosis of the heels as well as more severe hyperkeratotic gluconolactone and – Moisturization conditions such as psoriasis vulgaris and lamellar ichthyosis. acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, less common mild to severe dry skin bionic acids Lamellar IchthyosisElsevier, Inc. Psoriasis Vulgaris conditions seen in dermatological maltobionic acid – Skin barrier strengthening 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful practice. An 18-year-old male patient with lamellar ichthyosis was treated with In a randomized, double-blind, bilateral clinical trial, 24 adults with Test Product PDS Cream twiceyet dailygentle for 2skincar weeks withe ingr significantedient imprwithovement multiple in the benefits to prmoderateotect skin plaque and psoriasis used PDS Cream and 6% salicylic acid cream appearance andreverse texture theof the visible treated signs skin. The of stratumaging. cor Posterneum showed presented at the(Salex Summer® (6% Salicylic Acid) Cream, Coria Laboratories, Ltd., Forth Worth, – Antioxidant PDS Cream reduced thicknessAcademy and scaling Meeting and impr ofoved the hydration.American Academy of DermatologyTX, USA), Chicago, to descale IL,psoriatic plaques on opposite sides of the body twice References Vitamin E Tocopheryl acetate (Problem Dry Skin Cream, NeoStrata® Company, Inc, Princeton, NJ, USA) 8 August 4-8, 2010. daily for 2 weeks. At the end of therapy, PDS Cream reduced scaling and – Emollient Skin Affected by Lamellar Ichthyosis improved overall psoriasis severity significantly better and faster than 6% 1. Shwayder T. Disorders of keratinization: diagnosis and management. Am J Key Benefit Ingredients 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind,salicylic randomized, acid cream. Clin Dermatol. 2004;5(1):17-29. 2. Lodén M. Role of topical emollients and moisturizers in the treatment of dry bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-88. Formulation Component Ingredients Benefits for Problem Dry Skin 3. Van Scott EJ and Yu RJ. α -Hydroxyacids, polyhydroxy acids, aldobionic – Reduction in skin roughness hydroxy acid cream to reduce scaling of lesions associated with moderate, acids and their topical actions. In Baran R and Maibach HI, editors: Psoriatic Plaque on the Left Knee Textbook of Cosmetic Dermatology, 3rd Edition, London and New York, – Exfoliation chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of Emollient/occlusive 20% blend of and dryness on contact 15% blend of glycolic 2005, Taylor & Francis Group. – Normalization of epidermal the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. 4. Van Scott EJ and Yu RJ. Control of keratinization with α-hydroxy acids and Alpha hydroxy acids acid, lactic acid, and and stratum corneum related compounds: topical treatment of ichthyotic disorders. Arch vehicle oils and beeswax – Long-lasting feeling Before mandelicAfter acid 2 weeks Dermatol. 1974;110:586-590. thickness 5. Berardesca E, Distante F, Vignoli GP, Oresajo C, Green B. Alpha of moisturization (twice-a-day application) hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. 1997 Dec;137(6):934-8. 5% blend of – Light exfoliation Poly hydroxy / 6. Green BA and Briden ME. PHAs and bionic acids: Next generation hydroxy gluconolactone and – Moisturization Before acids. In Draelos ZD, editor: Cosmeceuticals, 2nd Edition, 2009, After 2 weeks (twice-a-day application) bionic acids Elsevier, Inc. maltobionic acid – Skin barrier strengthening – Enhanced product mildness 7. Brouda I, Edison BL, Weinkauf RL, Green BA. Maltobionic acid, a powerful Amphoteric Agent Arginine yet gentle skincare ingredient with multiple benefits to protect skin and and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves– Antioxidantoverall severity of reverse the visible signs of aging. Poster presented at the Summer Vitamin E Tocopheryl acetate Academy Meeting of the American Academy of Dermatology, Chicago, IL, the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice– Emollient daily use. August 4-8, 2010. Poster exhibit at the 69th Annual Meeting of the American Academy of 8. Green BA, Edison BL, Clark AR, Feldman SR. Double-blind, randomized, bilateral comparison of topical 6% salicylic acid cream and 20% alpha/poly – Reduction in skin roughness Dermatology, New Orleans, LA, February 4-8, 2011. P1619 hydroxy acid cream to reduce scaling of lesions associated with moderate, chronic plaque psoriasis. Poster presented at the 68th Annual Meeting of Emollient/occlusive 20% blend of and dryness on contact the American Academy of Dermatology, Miami, FL, March 5 – 9, 2010. vehicle oils and beeswax – Long-lasting feeling Before After 2 weeks of moisturization (twice-a-day application)

After 2 weeks (twice-a-day application) – Enhanced product mildness Amphoteric Agent Arginine and gentle delivery of AHAs PDS Cream exfoliates, hydrates, and smoothes PDS Cream reduces scaling and improves overall severity of the hyperkeratotic skin of lamellar ichthyosis. psoriasis symptoms after 2 weeks of twice daily use. Poster exhibit at the 69th Annual Meeting of the American Academy of Dermatology, New Orleans, LA, February 4-8, 2011. P1619