Corrigendum To: Association of Polymorphisms in MALAT1 with The

Biology of Reproduction, 2021, 104(4), 935–938 doi:10.1093/biolre/ioab030 Corrigendum Advance Access Publication Date: 26 February 2021

Corrigendum Corrigendum to: Association of polymorphisms in MALAT1 with the risk of endometriosis in Southern Chinese women Downloaded from https://academic.oup.com/biolreprod/article/104/4/935/6150604 by guest on 30 September 2021

Guange Chen1,†, Mingyao Zhang1,†, Zongwen Liang1, Sailing Chen1, Feng Chen1, Jiawei Zhu1, Manman Zhao1,ChaoyiXu1, Jing He2, Wenfeng Hua3,*, and Ping Duan1,*

1Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China,, 2Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China and and 3Department of Laboratory Medicine and Central Laboratories, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China

*Correspondence: Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China. Tel: +8613587430406; E-mail: [email protected]; Department of Laboratory Medicine and Central Laboratories, Guangdong Second Provincial General Hospital, Guangzhou 510317, Guangdong, China. Tel: +8615914263849; E-mail: [email protected]

Biology of Reproduction, Volume 102, Issue 4, April 2020, Pages 943-949, doi: 10.1093/biolre/ioz218.

In the originally published version of this manuscript, the incorrect tables were uploaded and have since been replaced with the correct tables. The description of the tables are consistent with the replacement tables and have not been modified. Hence, the scientific discoveries and conclusions of this article are unaffected by the error.

© The Author(s) 2021. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: [email protected] 935 936 Corrigendum, 2021, Vol. 104, No. 4

Ta b l e 1. Frequency distribution of selected variables for endometriosis cases and controls

Characteristic Case (n = 555) Control (n = 535) pa No. (%) No. (%)

Age 0.081 Age range, years 19–57 18–60 Mean ± SD 34.84 ± 7.37 34.84 ± 7.37 ≤35 335 (60.36%) 295 (55.14%) ≥35 220 (39.64%) 240 (44.86%) Abortion <0.001 ≤1 261 (47.03%) 491 (91.78%) >1 294 (52.97%) 44 (8.22%)

Delivery 0.296 Downloaded from https://academic.oup.com/biolreprod/article/104/4/935/6150604 by guest on 30 September 2021 ≤1 76 (13.69%) 62 (11.59%) >2 479 (86.31%) 473 (88.41%) BMI 0.072 <18.5 64 (8.56%) 47 (11.41%) 18.5 ≤ BMI ≤ 24.9 368 (65.40%) 342 (66.85%) 25.0 ≤ BMI ≤ 29.9 105 (23.38%) 123 (19.02%) 30.0 ≤ BMI ≤ 40 15 (2.66%) 14 (2.72%) FIGO stage I-II 415 (74.77%) III-IV 140 (25.23%)

aTwo-sided χ2 test for distributions between endometriosis cases and free controls.

Ta b l e 2 . Association between Selected Polymorphisms and endometriosis by Logistic Regression Analyses

Genotype Cases (N = 555) Controls (N = 535) Crude OR (95% CI) pa Adjusted OR (95% CI) pb

MALAT1 rs591291 C > T, HWE = 0.617 CC 177(32.2%) 212(39.8%) 1.00 1.00 CT 269(48.9%) 244(45.8%) 1.32 (1.01–1.72) 0.039 1.36 (1.00–1.85) 0.050 TT 104(18.9%) 77 (14.4%) 1.62 (1.13–2.31) 0.008 1.55 (1.03–2.33) 0.037 Dominant 1.39 (1.09–1.79) 0.009 1.41 (1.05–1.88) 0.021 Recessive 1.38 (1.00–1.91) 0.050 1.30 (0.90–1.88) 0.166 Additive 1.28 (1.08–1.52) 0.005 1.26 (1.04–1.54) 0.020 MALAT1 rs664589 C > G, HWE = 0.246 CC 462(83.5%) 445(83.9%) 1.00 1.00 CG 84(15.2%) 79 (15.4%) 1.02(0.73–1.43) 0.889 1.24 (0.85–1.81) 0.265 GG 7(1.3%) 6 (0.8%) 1.12 (0.38–3.37) 0.834 0.55 (0.14–2.20) 0.400 Dominant 1.03 (0.75–1.42) 0.852 1.18 (0.82–1.71) 0.377 Recessive 1.12 (0.37–3.35) 0.840 0.54 (0.14–2.12) 0.374 Additive 1.03 (0.77–1.38) 0.825 1.11 (0.79–1.56) 0.554 MALAT1 rs4102217 G > C, HWE = 0.065 GG 407(74.0%) 420(78.5%) 1.00 1.00 CG 130(23.6%) 103(19.3%) 1.30(0.97–1.75) 0.076 1.34 (0.96–1.88) 0.085 CC 13(1.2%) 12(2.2%) 1.12 (0.50–2.48) 0.784 1.34 (0.55–3.25) 0.521 Dominant 1.28 (0.97–1.70) 0.082 1.34 (0.97–1.85) 0.073 Recessive 1.06 (0.48–2.33) 0.895 1.25 (0.52–3.03) 0.617 Additive 1.22 (0.95–1.55) 0.120 1.27 (0.97–1.68) 0.088 Combined effect of risk genotypesc 0 173 (31.86%) 188 (35.54%) 1.00 1.00 1 156 (28.73%) 181 (34.22%) 0.94 (0.70–1.26) 0.666 0.83 (0.58–1.17) 0.282 2 199 (36.65%) 145 (27.41%) 1.49 (1.11–2.01) 0.008 1.56 (1.11–2.21) 0.011 3 15 (2.76%) 15 (2.84%) 1.09 (0.52–2.29) 0.827 1.30 (0.58–2.95) 0.524 0.017 1.22 (1.04–1.43) 0.013 0–1 329(77.11%) 369 (81.72%) 1.00 1.00 2–3 214(22.89%) 160 (18.28%) 1.50 (1.17–1.93) 0.0017 1.69 (1.26–2.26) 0.0005

a χ2test for genotype distributions between endometriosis patients and controls. bAdjusted for age, BMI, delivery, abortion. cRisk genotype was with rs591291 CT/TT, rs664589 CG/GG and rs4102217 CG/CC. Corrigendum, 2021, Vol. 104, No. 4 937 a P 2.30 (1.45–3.65) 0.0004 1.45 (1.03–2.05) 0.034 0.41 (0.19–0,87) 0.019 1.55 (1.14–2.10) 0.005 1.98 (1.06–3.69) 0.033 AOR (95% CI) Downloaded from https://academic.oup.com/biolreprod/article/104/4/935/6150604 by guest on 30 September 2021 MALAT1 a P AOR (95% CI) 328/288 6/3 1.76 (0.44–7.08) 0.429 252/216 80/79 0.87 (0.61–1.24) 0.440 472/465 5/6 0.82 (0.25–2.71) 0.747 349/383 127/90 104/119 0/4 - - 72/101 31/22 P MALAT1 AOR (95% CI) 1.42 (1.02–1.98) 0.036 1.48 (1.13–1.93) 0.004 2.18 (1.25–3.83) 0.006 rs591291 (case/control) rs664589 (case/control) rs4102217 (case/control) MALAT1 CC CT/TT CG/CC GG GG CG/CC 24.929.9 116/12940 28/54 247/212 6/2 77/68 1.30 (0.95–1.77) 9/12 0.103 361/335 0.25 6/2 (0.04–1.54) 0.135 2.78 (0.56–13.89) 0.212 15/14 273/265 0/0 92/77 - 1.16 (0.82–1.64) 0.403 - 11/11 4/3 1.33 (0.24–7.41) 0.742 ≤ ≤ ≤ Stratification analysis of risk genotypes with endometriosis susceptibility BMI BMI BMI ≤ ≤ ≤ Adjusted for age, BMI, delivery, abortion. a 12 92/18 147/188 198/26 327/283 1.49 (0.78–2.85) 0.229 287/43 6/1 0.90 (0.11–7.65) 0.922 222/35 69/9 1.21 (0.55–2.64) 0.634 18.5 25/22 39/25 1.37 (0.64–2.94) 0.415 63/47 1/0 - - 48/34 16/13 0.87 (0.37–2.05) 0.753 3535 103/116 73/96 227/178 146/143 1.34 (0.92–1.97) 0.130 218/236 1/3 0.36 (0.04–3.50) 0.379 155/204 63/36 11 85/194 175/295 30/24 1.35 (0.99–1.86) 46/38 0.060 0.97 (0.49–1.93) 259/481 1/5 0.927 0.37 (0.04–3,20) 74/59 0.367 2/0 185/385 74/106 - - 58/37 16/25 Ta b l e 3 . Variables Age ≤ ≥ Abortion ≤ > Delivery ≤ > BMI < 18.5 30.0 25.0 FIGO Stage I-IIIII-IV 333/456 113/456 77/77 27/77 1.34 (0.90–2.00) 1.36 (0.77–2.38) 0.157 0.287 408/524 138/524 6/6 1/6 0.67 (0.16–2.77) 0.28 (0,02–3.56) 0.577 0.329 300/420 107/420 110/115 53/115 1.38 (0.98–1.96) 1.15 (0.69–1.91) 0.069 0.594 938 Corrigendum, 2021, Vol. 104, No. 4

Ta b l e 4 . The frequency of inferred haplotypes of MALAT1 based on observed genotypes and their association with the risk of endometriosis rs591291 rs664589 rs4102217 Cases(N = 555) Controls(N = 535) Crude AOR (95% CI) p Adjusted AOR (95% CI) pa

C C G 531(48.90%) 583(55.10%) 1.00 1.00 T C G 305 (28.08%) 262(24.76%) 1.28 (1.04–1.56) 0.018 1.20 (0.95–1.52) 0.129 C G G 2(0.18%) 3 (0.28%) 0.73 (0.12–4.40) 0.733 0.48 (0.05–4.32) 0.513 C G C 0(0.0%) 0(0.0%) - - - - T G G 95(8.75%) 87(8.22%) 1.20 (0.88–1.64) 0.257 1.29 (0.90–1.84) 0.169 T G C 0(0.0%) 1 (0.09%) ---- C C C 81(7.46%) 77 (7.28%) 1.16 (0.83–1.61) 0.397 1.17 (0.80–1.71) 0.430 T C C 72(6.63%) 45(4.25%) 1.76 (1.19–2.60) 0.005 1.85 (1.19–2.86) 0.006 P=0.019 P=0.016

aAdjusted for age, BMI, delivery, abortion. Downloaded from https://academic.oup.com/biolreprod/article/104/4/935/6150604 by guest on 30 September 2021