Biology of Reproduction, 2021, 104(4), 935–938 doi:10.1093/biolre/ioab030 Corrigendum Advance Access Publication Date: 26 February 2021 Corrigendum Corrigendum to: Association of polymorphisms in MALAT1 with the risk of endometriosis in Southern Chinese women Downloaded from https://academic.oup.com/biolreprod/article/104/4/935/6150604 by guest on 30 September 2021 Guange Chen1,†, Mingyao Zhang1,†, Zongwen Liang1, Sailing Chen1, Feng Chen1, Jiawei Zhu1, Manman Zhao1,ChaoyiXu1, Jing He2, Wenfeng Hua3,*, and Ping Duan1,* 1Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China,, 2Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China and and 3Department of Laboratory Medicine and Central Laboratories, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China *Correspondence: Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China. Tel: +8613587430406; E-mail: [email protected]; Department of Laboratory Medicine and Central Laboratories, Guangdong Second Provincial General Hospital, Guangzhou 510317, Guangdong, China. Tel: +8615914263849; E-mail: [email protected] Biology of Reproduction, Volume 102, Issue 4, April 2020, Pages 943-949, doi: 10.1093/biolre/ioz218. In the originally published version of this manuscript, the incorrect tables were uploaded and have since been replaced with the correct tables. The description of the tables are consistent with the replacement tables and have not been modified. Hence, the scientific discoveries and conclusions of this article are unaffected by the error. © The Author(s) 2021. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: [email protected] 935 936 Corrigendum, 2021, Vol. 104, No. 4 Ta b l e 1. Frequency distribution of selected variables for endometriosis cases and controls Characteristic Case (n = 555) Control (n = 535) pa No. (%) No. (%) Age 0.081 Age range, years 19–57 18–60 Mean ± SD 34.84 ± 7.37 34.84 ± 7.37 ≤35 335 (60.36%) 295 (55.14%) ≥35 220 (39.64%) 240 (44.86%) Abortion <0.001 ≤1 261 (47.03%) 491 (91.78%) >1 294 (52.97%) 44 (8.22%) Delivery 0.296 Downloaded from https://academic.oup.com/biolreprod/article/104/4/935/6150604 by guest on 30 September 2021 ≤1 76 (13.69%) 62 (11.59%) >2 479 (86.31%) 473 (88.41%) BMI 0.072 <18.5 64 (8.56%) 47 (11.41%) 18.5 ≤ BMI ≤ 24.9 368 (65.40%) 342 (66.85%) 25.0 ≤ BMI ≤ 29.9 105 (23.38%) 123 (19.02%) 30.0 ≤ BMI ≤ 40 15 (2.66%) 14 (2.72%) FIGO stage I-II 415 (74.77%) III-IV 140 (25.23%) aTwo-sided χ2 test for distributions between endometriosis cases and free controls. Ta b l e 2 . Association between Selected Polymorphisms and endometriosis by Logistic Regression Analyses Genotype Cases (N = 555) Controls (N = 535) Crude OR (95% CI) pa Adjusted OR (95% CI) pb MALAT1 rs591291 C > T, HWE = 0.617 CC 177(32.2%) 212(39.8%) 1.00 1.00 CT 269(48.9%) 244(45.8%) 1.32 (1.01–1.72) 0.039 1.36 (1.00–1.85) 0.050 TT 104(18.9%) 77 (14.4%) 1.62 (1.13–2.31) 0.008 1.55 (1.03–2.33) 0.037 Dominant 1.39 (1.09–1.79) 0.009 1.41 (1.05–1.88) 0.021 Recessive 1.38 (1.00–1.91) 0.050 1.30 (0.90–1.88) 0.166 Additive 1.28 (1.08–1.52) 0.005 1.26 (1.04–1.54) 0.020 MALAT1 rs664589 C > G, HWE = 0.246 CC 462(83.5%) 445(83.9%) 1.00 1.00 CG 84(15.2%) 79 (15.4%) 1.02(0.73–1.43) 0.889 1.24 (0.85–1.81) 0.265 GG 7(1.3%) 6 (0.8%) 1.12 (0.38–3.37) 0.834 0.55 (0.14–2.20) 0.400 Dominant 1.03 (0.75–1.42) 0.852 1.18 (0.82–1.71) 0.377 Recessive 1.12 (0.37–3.35) 0.840 0.54 (0.14–2.12) 0.374 Additive 1.03 (0.77–1.38) 0.825 1.11 (0.79–1.56) 0.554 MALAT1 rs4102217 G > C, HWE = 0.065 GG 407(74.0%) 420(78.5%) 1.00 1.00 CG 130(23.6%) 103(19.3%) 1.30(0.97–1.75) 0.076 1.34 (0.96–1.88) 0.085 CC 13(1.2%) 12(2.2%) 1.12 (0.50–2.48) 0.784 1.34 (0.55–3.25) 0.521 Dominant 1.28 (0.97–1.70) 0.082 1.34 (0.97–1.85) 0.073 Recessive 1.06 (0.48–2.33) 0.895 1.25 (0.52–3.03) 0.617 Additive 1.22 (0.95–1.55) 0.120 1.27 (0.97–1.68) 0.088 Combined effect of risk genotypesc 0 173 (31.86%) 188 (35.54%) 1.00 1.00 1 156 (28.73%) 181 (34.22%) 0.94 (0.70–1.26) 0.666 0.83 (0.58–1.17) 0.282 2 199 (36.65%) 145 (27.41%) 1.49 (1.11–2.01) 0.008 1.56 (1.11–2.21) 0.011 3 15 (2.76%) 15 (2.84%) 1.09 (0.52–2.29) 0.827 1.30 (0.58–2.95) 0.524 0.017 1.22 (1.04–1.43) 0.013 0–1 329(77.11%) 369 (81.72%) 1.00 1.00 2–3 214(22.89%) 160 (18.28%) 1.50 (1.17–1.93) 0.0017 1.69 (1.26–2.26) 0.0005 a χ2test for genotype distributions between endometriosis patients and controls. bAdjusted for age, BMI, delivery, abortion. cRisk genotype was with rs591291 CT/TT, rs664589 CG/GG and rs4102217 CG/CC. Corrigendum, 2021, Vol. 104, No. 4 Ta b l e 3 . Stratification analysis of risk genotypes with endometriosis susceptibility Variables MALAT1 AOR (95% CI) P MALAT1 AOR (95% CI) Pa MALAT1 AOR (95% CI) Pa rs591291 (case/control) rs664589 (case/control) rs4102217 (case/control) CC CT/TT CG/CC GG GG CG/CC Age ≤35 103/116 227/178 1.42 (1.02–1.98) 0.036 328/288 6/3 1.76 (0.44–7.08) 0.429 252/216 80/79 0.87 (0.61–1.24) 0.440 ≥35 73/96 146/143 1.34 (0.92–1.97) 0.130 218/236 1/3 0.36 (0.04–3.50) 0.379 155/204 63/36 2.30 (1.45–3.65) 0.0004 Abortion ≤1 85/194 175/295 1.35 (0.99–1.86) 0.060 259/481 1/5 0.37 (0.04–3,20) 0.367 185/385 74/106 1.45 (1.03–2.05) 0.034 >1 92/18 198/26 1.49 (0.78–2.85) 0.229 287/43 6/1 0.90 (0.11–7.65) 0.922 222/35 69/9 1.21 (0.55–2.64) 0.634 Delivery ≤1 30/24 46/38 0.97 (0.49–1.93) 0.927 74/59 2/0 - - 58/37 16/25 0.41 (0.19–0,87) 0.019 >2 147/188 327/283 1.48 (1.13–1.93) 0.004 472/465 5/6 0.82 (0.25–2.71) 0.747 349/383 127/90 1.55 (1.14–2.10) 0.005 BMI <18.5 25/22 39/25 1.37 (0.64–2.94) 0.415 63/47 1/0 - - 48/34 16/13 0.87 (0.37–2.05) 0.753 18.5 ≤ BMI ≤ 24.9 116/129 247/212 1.30 (0.95–1.77) 0.103 361/335 6/2 2.78 (0.56–13.89) 0.212 273/265 92/77 1.16 (0.82–1.64) 0.403 25.0 ≤ BMI ≤ 29.9 28/54 77/68 2.18 (1.25–3.83) 0.006 104/119 0/4 - - 72/101 31/22 1.98 (1.06–3.69) 0.033 30.0 ≤ BMI ≤ 40 6/2 9/12 0.25 (0.04–1.54) 0.135 15/14 0/0 - - 11/11 4/3 1.33 (0.24–7.41) 0.742 FIGO Stage I-II 333/456 77/77 1.34 (0.90–2.00) 0.157 408/524 6/6 0.67 (0.16–2.77) 0.577 300/420 110/115 1.38 (0.98–1.96) 0.069 III-IV 113/456 27/77 1.36 (0.77–2.38) 0.287 138/524 1/6 0.28 (0,02–3.56) 0.329 107/420 53/115 1.15 (0.69–1.91) 0.594 aAdjusted for age, BMI, delivery, abortion. 937 Downloaded from https://academic.oup.com/biolreprod/article/104/4/935/6150604 by guest on 30 September 2021 September 30 on guest by https://academic.oup.com/biolreprod/article/104/4/935/6150604 from Downloaded 938 Corrigendum, 2021, Vol. 104, No. 4 Ta b l e 4 . The frequency of inferred haplotypes of MALAT1 based on observed genotypes and their association with the risk of endometriosis rs591291 rs664589 rs4102217 Cases(N = 555) Controls(N = 535) Crude AOR (95% CI) p Adjusted AOR (95% CI) pa C C G 531(48.90%) 583(55.10%) 1.00 1.00 T C G 305 (28.08%) 262(24.76%) 1.28 (1.04–1.56) 0.018 1.20 (0.95–1.52) 0.129 C G G 2(0.18%) 3 (0.28%) 0.73 (0.12–4.40) 0.733 0.48 (0.05–4.32) 0.513 C G C 0(0.0%) 0(0.0%) - - - - T G G 95(8.75%) 87(8.22%) 1.20 (0.88–1.64) 0.257 1.29 (0.90–1.84) 0.169 T G C 0(0.0%) 1 (0.09%) ---- C C C 81(7.46%) 77 (7.28%) 1.16 (0.83–1.61) 0.397 1.17 (0.80–1.71) 0.430 T C C 72(6.63%) 45(4.25%) 1.76 (1.19–2.60) 0.005 1.85 (1.19–2.86) 0.006 P=0.019 P=0.016 aAdjusted for age, BMI, delivery, abortion.