UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER Discovery Research Annual Report 2019

Grand Challenges Building Cross-Campus Research Collaborations

TURNING RESEARCH INTO CURES UNM Health Sciences Center UNM HEALTH SCIENCES CENTER Research Annual Report 2019 VISION Managing Editor Michael Haederle The Health Sciences Center will Design work with community partners to help New Mexico make more Jana Fothergill progress in health and health equity than any other state. Contributing Editors Emily Monteiro Morelli MISSION Yamhilette Licon Muñoz We will provide an opportunity for New Mexicans to obtain an Nicole Maphis excellent education in health sciences, advance health discovery Photography Seth Fuller and innovation in the most important areas of human health and Jett Loe ensure that all populations in New Mexico have access to the Allan Stone highest-quality health care. iStock by Dreamstime CORE VALUES The UNM Health Sciences Center’s mission is guided by our values of excellence in education; patient care and research; commitment to service; quality and safety; integrity and accountability; respect and compassion for all people; teamwork and collaboration and providing hope for those we serve.

©2019 The University of New Mexico Health Sciences Center Office of Research Published by the HSC Communications Department Special thanks to Stacy Bigbie, James MacFarlane and Margaret Hart for their assistance Printed by Starline Printing, Albuquerque, N.M. See inside back cover for information on donating to bioscience research at the The University of New Mexico.

Contact voice 505-272-6950 fax 505-272-8738 hsc.unm.edu/research university of new mexico health sciences center

Research Annual Report 2019 CONTENTS

LETTERS Paul B. Roth, MD, MS, Chancellor for Health Sciences 2 Richard S. Larson, MD, PhD, Executive Vice Chancellor 3 Christine Kasper, PhD, RN, Dean, College of Nursing 4 Donald Godwin, PhD, Dean, College of Pharmacy 5 Tracie Collins, MD, MPH, Dean, College of Population Health 6 Martha Cole McGrew, MD, Executive Vice Dean, School of Medicine 7

FEATURES Reaching for the Top 8 HSC Researchers Take On UNM’s Grand Challenges Michael Haederle

Closing the Gap KL2 Scholars Program Enhances the Research Enterprise 12 Yamhilette Licon Muñoz Overcoming the Opioid Crisis 14 Research Moves From Bench to Bedside Nicole Maphis

Engineering Excellence 18 Christina Salas Leads BioDesign Initiative Emily Monteiro Morelli

2019 HSC Training Grants 20 2019 Research Excellence Awards 24 2019 HSC Grant Listings 27 Information for Donors Inside back cover

unm health sciences center 2019 1 hen it comes to Institutes of Health. Thanks to a $4 research, our name million NIH grant and matching W pretty much says it funding from the Health Sciences all – the UNM Health Sciences Center. Center, we will be able to commence Biomedical research is the backbone construction of a new wing on Pete of everything else we do, from pro- and Nancy Domenici Hall that will viding state-of-the-art patient care to allow us to catapult our research in educating the next generation of New . Mexico health care practitioners. Over the past year, our scientists I’m proud to report that in the and their research teams have paul b. roth, md, ms past year our researchers have once received much-deserved recognition again demonstrated their focus, their for their discoveries in areas like vac- passion and their truly amazing talent cine development, cancer treatment, Chancellor for innovation in multiple areas. Alzheimer’s therapy, community When President Garnett S. Stokes health interventions and much more. for Health issued her Grand Challenges to Overall, our researchers are Sciences advance signature research across the moving toward greater integration university at the end of last year, our with our clinical practitioners in faculty stepped forward with a host addition to their existing focus on of creative ideas. HSC researchers conducting basic science. This prom- successfully submitted two proposals ises to yield even more discoveries, – to promote successful aging and new applications of existing technol- address substance abuse – that stand ogy and improved ways of providing a strong chance of making a positive clinical care. impact in our community. And thanks to the major role Our extramural research funding played by the HSC in supporting the matches almost exactly where we New Mexico Bioscience Authority, were last year, despite an overall we are helping our state to realize the decline in federal research money. economic benefits of the cutting-edge This is thanks in large part to the research that happens here. skillful stewardship of our research These many developments speak enterprise. to the diversity and sophistication Laboratory space is a premium of our research environment. We on our campus, so one bright spot is have a great deal to be proud of, and the recent reinstatement of con- I look forward to seeing what we will struction funding from the National achieve in the coming year. █

2 unm health sciences center research annual report 2019 he UNM Health Award from the National Institutes Sciences Center’s of Health and the National Cancer T research mission Institute grant that supports our encompasses a thriving scientific Comprehensive Cancer Center. enterprise that is bringing hope We were fortunate to receive an for new cures to thousands of New NIH construction grant earlier this Mexicans. But it is also a grant-fund- year to support the addition of a ing powerhouse that makes a 16,000-square-foot addition to Pete significant contribution to our state’s and Nancy Domenici Hall, adjacent to economy and serves as an agent of the UNM North Golf Course. When it change in our communities. is completed, the new wing will house richard s. larson, md, phd This year, I’m pleased to report that faculty and laboratory space for our we continue our quarter century-long neurosciences and addictions-related record of steady increases in extra- research and will greatly enhance our Executive mural funding, with a total of nearly efforts in these two critically import- $200 million in grants that support ant areas. Vice Chancellor basic, translational and clinical We are also extending our impact for Health research that has a positive impact in multiple ways through forming on community health and health strategic partnerships with the private Sciences care throughout New Mexico. Many sector and with other institutions in of these impacts are discussed in the the community. We continue to play stories in this year’s report. a central role in developing the New We have made real progress in the Mexico Bioscience Authority, which study of substance use disorder, with received staff funding from the New a particular focus on finding ways to Mexico Legislature this year. stem the continuing tragedy of opioid We are a key player (along with overdose deaths in our state. The other local anchor institutions) in the research ranges from assessing the Healthy Neighborhoods Albuquerque impact of neonatal opioid exposure initiative, which is bringing jobs to developing new, more effective and addressing income inequalities medical/behavioral interventions and in order to improve health in our to new vaccines that could block the neighborhoods that need it the most. craving for drugs. Finally, I want to thank the stellar Along these lines, we spent much faculty and staff whose efforts are of the 2019 fiscal year planning for the reflected in this year’s grant listings. renewal of our key strategic grants – Your hard work is the key to our the Clinical and Translational Science success. █

unm health sciences center 2019 / letters 3 he College of Nursing priorities. One will focus on rural has made incredible health and health equity, while the T progress over the past other will tackle bio-behavioral health year in building a robust research and data science. We’re conducting a enterprise that will yield solutions search for faculty to chair these to urgent problems and improve departments. the health and health equity of New We received $500,000 in funding Mexicans. from the Legislature this year to This initiative starts with providing continue our leadership of the our students with a solid foundation New Mexico Nursing Education in clinical and biomedical research. Consortium, which works to coordi- christine kasper, phd, rn We’re already seeing a dramatic nate curricula in nursing programs improvement in how our program throughout the state. Dean stacks up against other institutions. We were pleased to fill 21 positions We’re now ranked No. 7 nationally over the past year. Among our new College of for our nursing-midwifery program, faculty is Mary Patricia Couig, PhD, Nursing and among the top 15% in the nation MPH, a retired rear admiral with for the master of science in nursing the U.S. Public Health Service, who program. We’ve also made an inter- assumed the Carter-Fleck Endowed national list of the top 200 nursing Professorship. She has extensive expe- programs in the world. rience in state disaster preparedness In a major step, we’re launching a and has led projects for the World new program to admit University of Health Organization. New Mexico freshmen directly into I have been fortunate to establish our bachelor of science in nursing a laboratory at UNM to continue my program. Applicants must already own research, and earlier this year, we have been admitted into the UNM received a subaward grant from the Honors College, and they can expect American Association of Colleges of to be doing research, just like other Nursing for the All of Us project – Health Sciences students. a major genome initiative to procure We’ll encourage these students to biological samples from a more pursue graduate studies, such as a diverse population. master’s-level advanced practice reg- This in turn will lead to more istered nurse or doctoral degree. We’ll representative laboratory research. also help students apply for intern- The New Mexico portion of the ships with the National Institutes of project has been extremely successful, Health to hone their research skills. as we were able to enroll many of our We’re restructuring the College residents in the study. █ into two departments to reflect these

4 unm health sciences center research annual report 2019 ollege of Pharmacy after pregnancy, as well as seeking faculty achieved more to identify earlier markers for Fetal C than $12.1 million Alcohol Spectrum Disorders. This in extramural funding in FY19, the will particularly benefit very young second-highest level of total research children who often slip through funding ever awarded to the College the cracks with current diagnostic in a single fiscal year. methods. In addition to many individually We are conducting research and funded research projects, we hold providing treatment to enhance the several nationally recognized federally lives of young adults in our LGBTQ funded center grants and program- community and those living with donald godwin, phd matic awards, and have hosted HIV. We are developing vaccines that prestigious research conferences that have the potential to significantly have drawn national and interna- improve the health of patients who Dean tional attendees. regularly suffer from Staphylococcus We continue to rank in the top aureus skin infections. And we are College of tier among the colleges of pharmacy developing a technology to mask Pharmacy in the nation – and we are highly the bitter taste of drugs for pediatric innovative. College faculty currently patients. hold 45 active U.S. patents and dozens In partnership with New Mexico of pending patent applications. We Department of Health, we are receive funding from an array of evaluating the rational and appropri- federal, foundation and industry ate use of anti-infective therapy to sponsors, and have numerous state prevent antibiotic resistance and to partnerships. treat tuberculosis. With both College Our faculty continue their tireless and state funding, we are developing efforts to improve public health and approaches to increase the availability address the health concerns for some and dispensing of naloxone to of New Mexico’s most vulnerable prevent deaths from opioid overdose. patient populations. Through industry and foundation A team of environmental health funding, we have developed and scientists was recently awarded $17 are evaluating a population health million in Phase 2 National Institutes curricular initiative to detect atrial of Health funding to assess the fibrillation in patients at high risk for impact of environmental exposures stroke. to abandoned mine waste on birth I am grateful to those in the outcomes and child development on College who are involved with our the Navajo Nation. research programs, and I am inspired We are examining the cardiovas- by their resolve to improve the health cular impacts of inhaled pollutants of people in New Mexico, the nation on maternal physiology during and and the world. █

unm health sciences center 2019 / letters 5 hat is population abuse and mental illness in New health? It is an inter- Mexico. W disciplinary approach Our vision is for the College of to elucidating the multiple determi- Population Health to be globally nants of health in order to under- recognized as a leader committed to stand why some groups are healthier health as a human right, thus we are than others, and to determine how to committed to promoting health and improve health and health outcomes social equity for everyone. Through for diverse communities. Population education, applied research, policy, health engages integrated strategies service and partnerships, the College tracie collins, md, mph to help communities improve of Population Health will: their health and expand access to • Educate a diverse workforce high-quality and affordable health equipped with competencies Dean care. in disease prevention, wellness, College of The College of Population Health social determinants, environmen- was established in 2016, becoming tal health, mental health, health Population the second college of its type in the care delivery and policy; country. The College has experienced • Leverage our collective expertise Health tremendous growth in its first-of-its- in epidemiology, biostatistics, kind undergraduate degree program social sciences, community health, – and successfully maintained the health policy and health care master of public health degree delivery to develop innovative program. interventions that are high-qual- I have now served as dean for the ity, data-driven and validated by College for just over five months. multiple sources of evidence; During this time, I have convened • Assess community, health system more than 200 one-on-one meetings. and environmental needs and I have learned quite a bit from our assets in order to map disease, excellent administrators, faculty and interventions and policies that community partners. Our expertise warrant in-depth attention to in educating the future workforce in improve health outcomes; population health and public health • Mobilize and expand partnerships is truly exceptional. within the UNM network, and We have two active research with tribal, regional and global centers. The Center for Participatory communities, public and private Research, led by Dr. Nina Wallerstein, institutions and government has multiple participatory research agencies to advance health and projects with tribal partners. The social equity; Transdisciplinary Research, Equity, • Grow and sustain a College that and Engagement Center, led by Dr. is organizationally and financially Lisa Cacari Stone, is a five-year, $7 strong with a climate that values million grant funded by the National and invests in human beings. Institutes of Health that brings I look forward to meeting more of together multiple academic depart- our stakeholders and I am excited for ments and community partners to the future of the College. █ address the root causes of substance

6 unm health sciences center research annual report 2019 am so pleased with the And as you’ll read in this issue, scholarly work being School of Medicine faculty are I done on our campus. I leading two of the three interdisci- am proud of each researcher and his plinary Grand Challenges initiatives or her research project – even more set in motion last year by University so when that research will ultimately president Garnett S. Stokes. have a positive effect on the health of Janice Knoefel, MD, professor New Mexicans. in the Departments of Internal This year, I want to highlight Medicine and Neurology, co-leads some of that research, as well as our the Successful Aging initiative, which learners who are doing research. will work to raise the threshold of martha cole mcgrew, md Their work speaks for itself! functional status at which a person Kimberly Page, PhD, MPH, pro- can remain independent, allowing fessor in the Department of Internal individuals to have the resources to Executive Vice Medicine, received a $2.8 million age in place. Dean, School grant from the National Institute Brandi Fink, PhD, assistant on Drug Abuse for the New Mexico professor in the Department of of Medicine Clinical Trials Node, which will Psychiatry & Behavioral Sciences, enable clinical research and practice co-leads the Substance Use Disorders to address substance use in diverse, initiative. This Grand Challenge will rural and underserved populations. take a coordinated, multi-systems This work has special relevance for approach to address substance New Mexico, which has long had use in New Mexico, making use of one of the highest opioid overdose evidence-based implementation mortality rates. projects. Akshay Sood, MD, professor in the Meanwhile, the Community of Department of Internal Medicine, Scholars, founded by medical stu- received a $700,000 grant from the dents who desired a more intensive National Institute of General Medical research experience, has evolved into Sciences to promote mentor inter- a registered student organization. ventions among Underrepresented Participants work closely with faculty Minority Researcher faculty at three to explore their areas of interest, Southwestern institutions and expand dedicating vacation and elective time the scientific scope of the National to research. Many have secured grant Research Mentoring Network. funding, presented results at national Yuri Yoshida, PT, PhD, director meetings and published their findings of the Fred Rutan Gait and Motion in peer-reviewed journals. Analysis Laboratory, has won recogni- Thank you to all of our researchers tion for providing a deeper empirical whose work improves the health of understanding of biomechanics New Mexico and the world! █ and muscle physiology regarding functional recovery after total knee arthroplasty.

unm health sciences center 2019 / letters 7 HSC Researchers Come Together to Confront the Grand Challenges

By Michael Haederle

ast fall, UNM President Garnett S. Stokes launched an ambitious L plan to recruit university faculty to propose interdisciplinary solutions to pressing social problems. Tackling these Grand Challenges, she said, would enable the university to have a tangible impact on people and society. President Stokes selected three Grand Challenges: Sustainable Water Resources, Successful Aging and Substance Use Disorders. The latter two are closely interwoven with

8 unm health sciences center research annual report 2019 REACHING FOR THE TOP

says HSC executive vice chancellor expertise centered on treating older Richard S. Larson, MD, PhD. “This patients. When President Stokes clearly reflects our commitment to issued her call for research, “We were conducting high-impact research that well-positioned to go for the Grand will translate into improved health Challenge, because we had already care for New Mexicans.” started meeting,” Knoefel says. Each of the Grand Challenge The proposal put forward on behalf teams has received funding to launch of Successful Aging started with pilot programs to test out potential prevention, reaching out to people solutions, Larson says. before they have age-related cognitive impairments and urging them to exer- The Successful Aging proposal cise and maintain social connections, has a special urgency because New Knoefel says. “The whole emphasis is Mexico’s population is rapidly aging, on compressing disability,” she says. ongoing research initiatives at the according to Knoefel. “We all are “We want to keep people as functional UNM Health Sciences Center. getting older,” she says. “There are and healthy as possible.” Janice Knoefel, MD, a geriatrician some things we can’t prevent. But a For those who are starting to show with a clinical practice at the UNM lot of what people think of as aging is deficits, it is important to know who Memory & Aging Center, heads up really disease. We’ve known that for they are. “We would start to identify the Successful Aging initiative, while a long, long time.” individuals at risk through health Brandi Fink, PhD, an assistant profes- The proposal grew out of an assessments at senior centers,” she sor in the Department of Psychiatry informal process begun within the says. The College of Nursing has been & Behavioral Sciences, co-leads the UNM School of Medicine in Fall conducting such assessments for Substance Use Disorders Grand 2018 by David Scrase, MD, a fellow more than 20 years, she says, but these Challenge with Katie Witkiewitz, geriatrician who earlier this year efforts could be expanded to include Regents’ Professor in the was appointed secretary of the New medical and pharmacy students. Department of Psychology. Mexico Human Services Department, “Once we have identified people “The Health Sciences Center was Knoefel says. who have needs, we have to do further very fortunate to have two of its pro- Scrase convened a series of assessment,” Knoefel says. This could posals selected as Grand Challenges,” meetings with faculty whose shared entail home visits from physical and

unm health sciences center 2019 / reaching for the top 9 “The whole emphasis is on compressing disability. We want to keep people as functional and healthy as possible.” – Janice Knoefel, MD

"(W)e will engage schools and commu- nities, general medical settings, specialty treatment settings and the criminal justice systems.” – Brandi Fink, PhD

10 unm health sciences center research annual report 2019 occupational therapists trained to across multiple systems to really try The Substance Use Disorders ask, “What can we recommend as to reverse the trend,” Fink says. “Part team, which includes collaborators professionals to keep people opti- of the way we’re going to do that is to from throughout the Health Sciences mally independent?” target the most-affected communities Center and across Main Campus, has And finally, when dementia and for intervention, while increasing the already garnered funding for nine other cognitive impairments require scientific basis for interventions.” pilot projects. intensive care, it’s important to pay The Grand Challenge has set a “As part of our Grand Challenge, attention to the caregivers, Knoefel high bar for success, Fink says. By with our money we are funding a says. 2030, it seeks to reduce alcohol, pilot study to evaluate the imple- “Our idea was to really start to opioid and other substance mortality mentation of Senate Bill 221, which test out if care management actually by 45% and substance-related conse- requires opioid overdose counseling makes a difference for the caregiver,” quences (including overdose, injury, and naloxone co-prescribing,” Fink she says. When caregivers feel and accidents) by 40%. It further says. Prescriptions for naloxone, overburdened, the people they’re seeks to cut crime, incarceration and which rapidly reverses the symptoms caring for make much higher use of recidivism by 20%, adverse childhood of an opioid overdose, have sharply health care resources and emergency experiences by 20%, and overall increased, and the number of over- department visits. economic costs of substance-related dose reversals has grown by nearly illness and death by 20%. two-thirds, she notes. Substance use disorder, including “To accomplish these goals, we will In another initiative, Fink plans addiction to alcohol, opioids and engage schools and communities, to engage with providers who have other substances, has taken a grim general medical settings, specialty received a mandatory notification toll on New Mexico families, says treatment settings and the criminal letter when a patient has died from Fink, who maintains a clinical prac- justice systems,” Fink says. One of an opioid drug they have prescribed. tice focused on addiction treatment the overarching aims is to enhance “We’re looking at using those as alongside her research interests. resilience against substance use opportunities to provide additional Some 66% of opioid overdose through prevention efforts, especially trainings, provide anxiety and depres- deaths are due to prescribed opioid in Native American and rural com- sion screens and train providers to medications, she says, while data munities, she says. rely on those screens in writing an from the Office of the Medical It is also important to improve opioid prescription,” she says. Investigator show that in every screening and treatment for She also wants to implement Albuquerque zip code eight to 12 substance use disorders in general an opioid stewardship program, to people die each year from an opioid medical and specialty treatment monitor opioid prescribing patterns overdose. “It’s an equal-opportunity settings. And there is a pressing need and intervene with prescribers when offender,” Fink says. to improve access to substance abuse necessary. “These are easy things to “What we’re looking to do is coor- treatment for those who have become put in place,” Fink says. “And they dinate and integrate interventions involved with the criminal justice have a big impact.” █ system, Fink says.

unm health sciences center 2019 / reaching for the top 11 Closing the Gap Between Basic Research and Patient Care The Success of UNM’s KL2 Scholar Program

12 unm health sciences center research annual report 2019 By Yamhilette Licon Muñoz

ranslational research involves Specifically, KL2 awards support our investigators focus on research applying multi-disciplinary career development for clinical questions that are in immediate Tresearch to improve health out- investigators. need by the community.” comes and community benefit. Since “The goal is to provide junior Currently, UNM has four KL2 2010, The University of New Mexico’s faculty assistant professors with some scholars. Eliseo Castillo, PhD, (FY17- Clinical and Translational Science guaranteed funding and protected present) studies immunity in the gut. Award has funded the UNM Clinical time so they can pursue translational Kathryn Frietze, PhD, (FY18–present), & Translational Science Center in its research,” says Matthew Campen, shown on page 17, tries to transform mission to enhance the transfer of PhD, UNM’s current KL2 director and antibody responses into targeted research from laboratories to clinical professor in the College of Pharmacy. therapeutic or prophylactic inter- practice and out into communities. “We have four slots at any given time.” ventions for infectious and chronic The KL2 Mentored Clinical When there is an opening, the KL2 diseases. Daryl Domman, PhD, (FY Research Scholar Awards are part program interviews candidates from 20-present) uses genomics to inves- of the National Institutes of Health inside and outside the state. Ideal tigate how infectious diseases, such Clinical and Translational Science candidates are health professionals as cholera, cause global pandemics Awards Program, which has the goal with a doctoral degree (e.g., PhD, in hopes of developing more effective of supporting a national network MD-PhD, PharmD, MD or equiva- programs to stem the spread of of medical research institutions to lent), with a minimum of two years of disease. Justin Baca, MD, PhD, (FY18– improve translational research. post-terminal degree research expe- present) tests the efficacy of novel rience. KL2 scholars are expected to point-of-care devices through clinical obtain extramural funding while in trials in the Emergency Department. the program and they commit to a The program has a multi- career in translational research. disciplinary, collaborative advisory Successful candidates generate a committee, and each scholar has two plan for a clinical and translational mentors: one who works with basic research project – this is a crucial part science, and the other with clinical of the selection process. science. “A lot of times we only do basic “Diseases are multifactorial,” science work that is far removed from Campen explains, “so we want our patients,” Campen says, “while this scholars to work in a multi-disci- program centers on the clinic, and plinary setting to solve translational research questions. We encourage them to embrace the complexities of those questions and take that per- spective forward into their careers.” KL2 Mentored Clinical Research Justin Baca, MD, PhD Scholar Awards promote the career development of junior faculty and help them become the next gener- ation of translational researchers. The NIH keeps track of how many of them are still doing clinical transla- tional research. “Our statistics so far show 100% success,” Campen says. “All our scholars are still doing translational research. Most of them work in UNM Eliseo Castillo, PhD Daryl Domman, PhD and are leaders in the program.” █

unm health sciences center 2019 / closing the gap 13 Overcoming the Opioid Crisis One Lab at a Time UNM Scientists Bring Research From Bench to Bedside

By Nicole Maphis

ith drug manufacturers Not surprisingly, as the opioid Ludmila Bakhireva, MD, PhD, facing litigation, bank- crisis continues to surge, staggering MPH, a professor and epidemiologist Wruptcy and restructuring, rates of opioid addiction are also seen in the UNM College of Pharmacy, many are asking who will pay the in pregnant women. recently published a small study in the tab for the nation’s opioid crisis. The tiniest victims of the opioid journal Early Human Development Unfortunately, it seems to be the crisis are exposed to the drugs in looking at the outcomes for those people who suffer from substance use utero, and after birth they often infants who receive MAT, versus those disorders and their families. In fact, experience neonatal opioid with- who don’t. more than 130 people die each day in drawal syndrome (NOWS). Symptoms The study, which involved 78 the as a result of opioid include prolonged crying, sleepless- maternal-infant pairs, observed that overdose, and at times the challenges ness, respiratory distress, excessive there was “little-to-no effect of MAT surrounding the opioid crisis seem sucking, tremors and even seizures, and pharmacological treatment of insurmountable. sometimes severe enough to cause NOWS on infant neurodevelopmental UNM Health Sciences Center permanent brain damage. and behavioral outcomes at 5-8 researchers are tackling the problem According to the Centers for months of age,” which hadn’t been on many fronts, from the bench to Disease Control and Prevention, inci- assessed before. the bedside – and back again. Often, dence of NOWS grew nearly 400% Interestingly they uncovered that these efforts run in parallel, but between 2000 and 2013, and could one of the side effects of MAT and the they work best together, using the affect as many as 2% of all births. The prolonged hospital stays that go along preclinical data observed in mouse typical intervention for a baby with with the treatment, could be “higher models and in cell cultures to inform suspected NOWS is close observation, family distress,” which will be the the clinical responses – and vice versa, followed by medication-assisted focus of future work. using clinical patient data sets to solve therapy (MAT), such as methadone or An ongoing research project, preclinical questions. buprenorphine. bringing together the clinical and Continued on pages 16-17

14 unm health sciences center research annual report 2019 The tiniest victims of the opioid crisis are exposed to the drugs in utero, and after birth they often experience neonatal opioid withdrawal syndrome.

Ludmila Bakhireva, MD, PhD

Continued on pages 16-17

unm health sciences center 2019 / overcoming the crisis 15 the pre-clinical worlds, between takes 17 years to get evidence into treatment program. Bakhireva and Nora Perrone- clinical practice,” Page says, but her As it turned out, when machine Bizzozero, professor in the node “seeks to shorten that interval learning was applied to fMRI studies Department of Neurosciences, seeks by engaging with clinicians in clinical of incarcerated women, it was able to identify and explore biomarkers settings.” In fact, her team has a to accurately predict which patients found in the umbilical cord blood of subcommittee investigating new would successfully complete a sub- infants. ideas for protocol development. This stance abuse treatment plan. In fact, They hope to determine which extremely active engagement group Fink’s algorithm was able to predict infants will most benefit from these is comprised of community stake- the outcome better than other clinical types of interventions. By identifying holders, including the UNM Brain assessments, such as psychopathy, and measuring these molecules called and Behavioral and Health Institute anxiety and depression, as well as micro-RNAs circulating in the blood, and the Department of Psychiatry & motivation for change or age, sex, IQ they hope to predict which children Behavioral Sciences, with an ultimate and years of substance use. will benefit most from interventions goal of growing collaborations in Fink’s work illustrating these following NOWS diagnosis. neighboring Colorado and Arizona. irregular neural connections, which New funding from the National “The strength of a SW-CTN is predicted outcomes for those on Institute on Drug Abuse has led to that New Mexico has a widely diverse a substance abuse treatment plan, the creation of a clinical trial node at population, which is largely rural,” could help to identify new targets for UNM to study, among other things, Page says. “Successful completion of drug interventions with the aim of the differences between injectable programs here could broadly translate reducing or eliminating substance use and sublingual applications of to the rest of the U.S.” disorder. buprenorphine, a common treatment Working to understand how sub- But what if we could stop opioid for opioid addiction. Other trials will stance use disorders change the brain addiction from even occurring in the begin soon on how to prevent and and affect substance abuse programs is first place? treat other substance use disorders. the focus of another lab, led by Brandi That’s what the lab of Kathryn The task of managing so many Fink, PhD, assistant professor in the Frietze, PhD, a KL2 scholar, and assis- researchers can seem overwhelming, Department of Psychiatry & Behavioral tant professor in the Department of but epidemiologist Kimberly Page, Sciences. Molecular Genetics & Microbiology, PhD, professor in the Department of Fink used functional magnetic hopes to do. Working with collabora- Internal Medicine, manages just fine. resonance imaging (fMRI) to assess tors Naomi Lee, at Northern Arizona Her group has worked hard at which parts of the brain would light University, and Bryce Chackerian, developing the Southwest Clinical up, signaling activation, during PhD, professor in of Molecular Trial Node (SW-CTN), the first of specific tasks. Then she programmed Genetics & Microbiology, Frietze’s its kind to be established at UNM a computer to calculate and learn project centers around the develop- in nearly 20 years, with the ultimate specific associations – a form of ment of a vaccine to target opioids. goal of reducing the medical conse- machine learning. The goal of this A recent $250,000 grant awarded quences of opioid addiction. project was to see if the complex to the team will focus on whether She is particularly focused on relationship between different regions using a virus-like particle (VLP) to reductions of soft tissue infections of the brain and their functional create a vaccine could prevent or halt and blood-borne pathogens in these network connectivity could predict drug addiction. The vaccine would patient populations. “It typically success or failure in a substance abuse elicit an immune response to opioid

16 unm health sciences center research annual report 2019 But what if we could stop opioid addiction from even occurring in the first place?

drugs, rendering the recipient unable to experience the “high” from the drugs. They got the idea for the project, after the National Institutes of Health had put out a call to the scientific community for new approaches to opioid vaccines. Other work being done on vaccines looks promising, except that these approaches typically Nora Perrone-Bizzozero, PhD require many immunizations because they do not last very long. Because a VLP platform tends to elicit a more robust immune response with fewer required immunizations, they hope their approach would be more useful in people with substance use disorders who typically have a more difficult time coming in for repeated treatments. Even though the work is still in its very early stages, Frietze says, “We have really promising results so far with our vaccine. We get very good responses in our initial animal studies. Next we plan on testing whether the vaccine prevents the effect of the drugs.” The diverse array of researchers and research methods to overcome the scourge of opioid abuse Kimberly Page, MD, MPH holds promise to help New Mexico and the world. █

Katherine Frietze, PhD

unm health sciences center 2019 / overcoming the crisis 17 Christina Salas (left) with Deanna Mercer, MD Engineering Excellence Christina Salas Brings Passion and Ingenuity to Developing Novel Technology

By Emily Monteiro Morelli

NM biomechanical engineer School of Engineering and from the Students brainstorm, then vet their Christina Salas, PhD, an HSC’s Biomedical Sciences Graduate ideas against a set of 10 acceptance Uassistant professor with Interprofessional Education pro- criteria, before splitting into groups cross appointments in the School grams, with the goal of developing to research and develop potential of Medicine and the School of medical devices,” she explains. devices for the bulk of the semester. Engineering, juggles a busy teaching Before the course starts, Salas iden- The class culminates with compet- load while finding time to run three tifies a focus area and then embarks on itive pitches before a panel. highly active labs. a holistic view of potential problems “It’s important to bring in Her devotion to her work exem- to solve. She brings in guest faculty to Anderson School of Management plifies UNM’s strong commitment to orient students to physical challenges faculty to help with marketing innovation and entrepreneurship. or limitations faced in their practices research, and other collaborators, One focus of her research results and takes students on field trips. angel investors and STC.UNM, to from a graduate course she teaches “We’ve looked at geriatrics, trauma advise students on all aspects of every fall semester based on the model and rehabilitation, and visited the development during the build-up to of fellowships at Stanford University. helicopter pad, the emergency room, their pitches,” she notes. “It’s a bio-design course open an ambulance bay and rehab facilities Winners receive $50,000 of seed to graduate students across the to see problems in action.” money and the chance to work

18 unm health sciences center research annual report 2019 closely with Salas in her lab. “I help them develop and test “Dr. Salas’ research is cutting-edge and will prototypes throughout the course of the year, and work through the steps revolutionize the way orthopedic surgery is of starting a business with them,” she performed over the next decade.” notes. Students work with STC. UNM – Richard S. Larson, MD, PhD to protect intellectual property and pursue patents, if appropriate. Winning devices have included attention to the problem of ruptured In 2018, Salas was awarded a a lower limb prosthetic device, a ligaments, such as torn anterior two-year supplemental grant from the device for emergency responders to cruciate ligaments. National Institutes of Health through lift bariatric patients, a device that Currently, the way to treat those the UNM Clinical & Translational universally fits wheelchairs to support injuries is to go to a site near the injury Science Center, with executive vice immobile limbs in stroke recovery, and and take a portion or all of a perfectly chancellor Richard S. Larson, MD, a diagnostic patch for biomarkers in functioning tendon to use in recon- PhD, serving as co-PI. “Dr. Salas’ interstitial fluid to detect traumatic structing the geometry of the ligament research is cutting-edge and will brain injury. by drilling bone tunnels, pulling the revolutionize the way orthopedic Salas’ second research effort focuses tendon through and tacking the ends surgery is performed over the next on education, working with co-princi- down with bone screws. decade,” Larson says. pal investigators David Groh, MD, and Salas found the challenge to Salas holds one patent, with several Deanna Mercer, MD, (her colleagues improve this process intriguing. pending and has published exten- in the Department of Orthopaedic “It is a very complex problem,” she sively and presented her work around Surgery & Rehabilitation) to measure says, “because you are working with the world. In 2019, she was a finalist outcomes in the use of drills, saws, functional tissue. So you don’t just for the Orthopaedic Research Society probes and other tools by surgical have to make it look right – it has to New Investigator Award, and recog- residents. be mechanically competent when nized by the National Institutes of “By turning surgical tools into someone is walking or running and Health at the Future Research Leader ‘smart’ tools by placing sensors bearing a load.” Conference as an invited lecturer and on them, we’re able to measure Salas saw an opportunity to solve recipient. residents’ motor skills performance this problem by going all-out to Her ability to bridge disciplines, and also evaluate training in the develop a total joint replacement innovate and forge partnerships also surgical program,” Salas says. The technology. makes her uniquely qualified for the team collaborates with seven other She and her team have developed role of special assistant to the Dean of Southwestern universities annually to a unique platform that combines 3-D Engineering for HSC relations. gather first-year resident data over the bio-printing and near-field electro- “In the past five or six years, Main course of four days, and then compare spinning to fabricate bone-ligament Campus and HSC have collaborated results. tissue engineering scaffolds in one on events such as the Hackathon “We can then look at contrasts unit. She is able to produce multi-ma- and Bioventure,” she says. “We are between programs and opportunities terial, multi-scale and biodegradable creating opportunities to bring in new to collaborate in training – for scaffolds and test their effectiveness faculty and bring people together.” instance, if one institution does with simulation. Salas’ remarkable talents and work consistently better with a certain “The intention is to produce a single ethic clearly represent the direction instrument,“ Salas explains. unit for total joint replacement, with of scientific research at UNM and However, it’s the exciting research biodegradable manufactured tissues beyond – innovating in and out of in Salas’ 3-D printing lab that has for eventual natural replacement by the laboratory space, making connec- garnered national attention. the body,” Salas explains. tions between disciplines, bringing In 2014, she was looking for an The excitement surrounding her researchers together and teaching orthopedics problem to tackle through work is palpable on campus and off. a generation of future scientists to the use of 3-D printing. She turned her achieve the same. █

unm health sciences center 2019 / engineering excellence 19 the university of new mexico health sciences center Training Grants 2019

Rosstin Ahmadian, PhD Candidate Eduardo Anaya Camden Bair, PhD Candidate T32 Scholar, NIH T32 Scholar, NIAID T32 Scholar, NIAID Oxidant signaling in pulmonary Infectious Disease, Cell Signaling, The impact of human adenovirus type hypertension 4 intratypic genetic variability on viral Mentor: Thomas Resta, PhD pathogenesis Mentor: Adriana Kajon, PhD

Victoria Balise, PhD Daniel Barto, PhD Cindy K. Blair, PhD, MPH K12 Scholar, NIGMS K12 Scholar, NIH KO7 Scholar, NCI Hematopoietic stem cells Computational psychiatry; neural Developing and disseminating home- Mentor: Jennifer Gillette, PhD markers of psychological disorders; based interventions to improve the health developmental neurobiology and well-being of underserved cancer Mentor: Elaine Bearer, MD, PhD survivor populations

Roger Brown, PhD Janie Rae Byrum, PhD Candidate Sharina Desai, PhD T32 Scholar, NIAID T32 Scholar, NIAID T32 Scholar NIAID Developing bioinformatics methods for T cell immunology, particularly motility T cell trafficking during ovarian cancer studying RNA processing events in cellular of T cells in lymph nodes and the molecular disease progression in the peritoneal differentiation of the immune system and structural factors that facilitate target tumor environment Mentor: Scott Ness, PhD cell identification Mentor: Sarah Adams, MD Mentor: Judy Cannon, PhD

20 unm health sciences center research annual report 2019 Tammi Duncan, PhD Daniel Falcon, PhD Máté Fischer, PhD Candidate K12 Scholar, NIH K12 Scholar, NIH T32 Scholar, NIAAA The potential role of zinc as a way to Studying the role of iron and other Using first trimester-equivalent binge- attenuate the carcinogenic effects of micronutrients in the initiation and drinking model to assess alterations to environmental metals on DNA repair progression of colorectal cancer gene expression, cell fate determination mechanisms Mentor: Xiang Xue, PhD and cortical regionalization in human Mentor: Laurie Hudson, PhD stem cell-derived cortical neurons Mentor: Jason Weick, PhD

Muskan Floren, PhD Candidate Selina Garcia, PhD Candidate Ryan E. Harvey, PhD Candidate F31 Scholar, NCI F31 Scholar, NHLBI T32 Scholar, NIAAA Acute myeloid leukemia resistance Cardiovascular physiology Understanding the impact of prenatal and relapse Mentor: Nikki Jernigan, PhD alcohol exposure on hippocampal- Mentor: Jennifer Gillette, PhD parahippocampal place, grid and head direction signals Mentor: Benjamin Clark, PhD

Julie In, PhD Elton Jhamba, PhD Benjamin Lantz, PhD Candidate KO1 Scholar, NIDDK K12 Scholar, NIH T32 Scholar, NIH Defining the functional characteristics of Developing super-resolution microscopy Pulmonary hypertension Enterohemorrhagic E. coli-Secreted Protein technologies to study protein-protein Mentor: Laura Gonzalez Bosc, PhD Mentors: Olga Kovbasnjuk, PhD; Eric interactions on mast cell membranes in Prossnitz, PhD; Jennifer Gillette, PhD; allergic responses, as well as the interplay of Edgar Boedeker, MD; Mary Estes, PhD receptor tyrosine kinases on cancer cells Mentors: Diane Lidke, PhD; Keith Lidke, PhD

unm health sciences center 2019 / training grants 21 Daniel A. Lujan, PhD Candidate Adrian J. Luna, PhD Candidate Perenkita Mendiola, PhD Candidate F31 Scholar, NCI F31 Scholar, NCI T32 Scholar, NIH RNA biology; breast cancer biology; Investigating the role of EGFR signaling Identification of endogenous regulators immunology in the HPV life-cycle of cystathione gamma-lyase in Mentors: Rebecca S. Hartley, PhD; Mentor: Michelle Ozbun, PhD endothelial cells Nora Perrone-Bizzozero, PhD Mentors: Nancy Kanagy, PhD; Laura Gonzalez Bosc, PhD

Emily Morin, PhD Sarah Olguin, PhD Candidate Erica Pascetti, PhD Candidate T32 Scholar, NIH T32 Scholar, NIAAA T32 Scholar, NIH Endothelial cholesterol regulation of Studying the mechanism of impaired Hematopoietic stem and progenitor cells vascular tone in hypertension and cognitive control after prenatal alcohol Mentor: Jennifer Gillette, PhD vascular disease exposure using touchscreen-adapted operant Mentor: Jay Naik, PhD behavior, in vivo electrophysiology, EEG recording, and immunohistochemistry Mentor: Jonathan Brigman, PhD

Gabriela Perales, PhD Candidate Melanie Rivera, PhD Candidate Rebecca Sena, PhD Candidate T32 Scholar, NIH F31 Scholar, NCI T32 Scholar, NIAAA Studying novel mechanisms that contribute Studying the role of Rac1 protein in the spread Researching the impact of prenatal to the teratogenic effects associated with of ovarian cancer ethanol exposure on histaminergic prenatal alcohol exposure Mentor: Angela Wandinger-Ness, PhD neurotransmission in the hippocampus Mentor: Amy Gardiner, PhD Mentors: Daniel Savage, PhD; C. Fernando Valenzuela, MD, PhD

22 unm health sciences center research annual report 2019 Hailey Sedam, PhD Crystal Vander Zanden, PhD Nikole Warner, PhD K12 Scholar, NIH K12 Scholar, NIH K12 Scholar, NIH Studying adenoid cystic carcinoma and Early aggregation events of amyloid Using a deep sequence-coupled biopanning investigating the molecular mechanisms beta (Alzheimer’s disease) technology to characterize the specificity and genomic signatures of this disease Eva Chi, PhD of the antibody response to DENV in sera Mentor: Scott Ness, PhD from infected patients Mentor: Kathryn Frietze, PhD

Jordan Weisend, PhD Candidate Lea Weston, PhD Candidate Christine Woods, PhD T32 Scholar, NIH T32 Scholar, NIAID K12 Scholar, NIH Cell and molecular mechanisms of Investigating the relationship between Examining the contribution(s) of GPER protection induced by spreading neuroinflammation and tau . in metabolic homeostasis and determining depolarizations occurring in remaining Determining the role of anti-inflammatory its therapeutic potential on adiposity viable brain tissues following stroke cytokine IL-10 in tauopathies, such as and metabolic dysfunction Mentor: C. William Shuttleworth, PhD Alzheimer’s disease Mentor: Eric Prossnitz, PhD Mentor: Kiran Bhaskar, PhD

Xiang Xue, PhD Sheldwin A. Yazzie, PhD, MPH KO2 Scholar, NIDDK K12 Scholar, NIH Iron metabolism in GI diseases Investigating disparate environmental Mentors: Eric Prossnitz, PhD; exposures and disease rates among Olga Kovbasnjuk, PhD disadvantaged populations, specifically on American Indian/Alaska Native populations Mentors: Charles Wiggins, PhD; Kevin English, DrPH

unm health sciences center 2019 / training grants 23 Excellence in Research Awards 2019

he UNM Health Sciences Center’s 11th Annual Research Day Awards Ceremony was held Nov. 15, 2019. The event, hosted by Executive Vice Chancellor Richard TLarson, MD, PhD, and Paul Roth, MD, MS, Chancellor for Health Sciences, recognized six scientists who were nominated by their peers and selected for recogni- tion by a faculty committee on the basis of their outstanding research contributions.

(From left to right) Paul B Roth, MD MS, Chancellor for Health Sciences; Lisa Cacari Stone, PhD; Esther Erdei, PhD, MPH; Angela Wandinger-Ness, PhD; Christina Salas, PhD; Thomas Resta, PhD; Richard S. Larson, MD, PhD

Esther Erdei, PhD, MPH analyzed clinical samples from study Thomas Resta, PhD Pharmacy participants for various biomarkers of Cell Biology & Physiology immune impairment. Her reputation Team Science Basic Science in immunology has also landed her on As an immunologist and epide- several review boards for NIH grant Thomas Resta’s research focuses on miologist in the Department of proposals. Since 2006, she has been chronic hypoxia and intermittent Pharmaceutical Sciences, Esther Erdei co-author on 16 papers with other hypoxia-induced pulmonary hyper- has been involved in several major pop- UNM researchers. These have included tension. As a principal investigator, he ulation-based studies, particularly in both technical papers in immunology has maintained continuous funding Native American communities in New and others on the application of immu- through the National Institutes of Mexico and South Dakota. She has nology to public health. Health and the American Heart

24 unm health sciences center research annual report 2019 Association for nearly 20 years. Christina Salas, PhD Angela Wandinger-Ness, He holds an R01 grant examining Orthopaedics & Rehabilitation PhD vascular smooth muscle signaling Junior Faculty in intermittent hypoxia-induced Pathology pulmonary hypertension. In 2016, he With dual appointments in the Teaching and Learning took over as the principal investigator Department of Orthopaedics & The associate director for Education, and director of the T32 grant Minority Rehabilitation and the School of Training and Mentoring at the UNM Institutional Research Training Engineering, Christina Salas maintains Comprehensive Cancer Center, Program in Cardiovascular Biology. a busy research and teaching sched- Angela Wandinger-Ness oversees His research has particular relevance ule. In her lab she is developing an the Cancer Center’s education and in New Mexico, where the incidence advanced biomanufacturing process to training program. Wandinger-Ness, of cardiovascular-related disease is fabricate bone-ligament tissue scaf- the Victor and Ruby Hansen Surface high, especially among the Hispanic folds. She is quickly becoming a leader Endowed Professor in Cancer Cell and Native American populations. in the area of advancing biomanufac- Biology and Clinical Translation, turing for orthopaedic applications. was awarded a competitive National This year, she was recognized by the Lisa Cacari Stone, PhD Cancer Institute Continuing Umbrella National Institutes of Health as a Population Health of Research Experiences award. Over Future Research Leader – one of 25 the past five years, the program has Population Science nationally. She was also an invited supported the research training of 57 Lisa Cacari Stone is the founder panelist for the Advances in 3-D undergraduate and high school Native and principal investigator for the Printing and Biofabrication Workshop American scholars at the Cancer Transdisciplinary Research, Equity at the 2019 Orthopaedic Research Center. She has also had a profound and Engagement (TREE) Center, Society annual meeting. impact on hundreds trainees in basic, funded by the National Institutes of translational and clinical research. Health, which tests multi-level inter- Mark Unruh, MD ventions with partner faculty, staff Internal Medicine and students drawn from across the Clinical Science UNM campus. She brings “real-life” experience to understanding health Mark Unruh is a physician scientist and disease as a former licensed who focuses on improving patient behavioral health provider, director outcomes in chronic kidney disease. for a comprehensive child welfare He has two primary avenues of investi- agency, director of senior services, gation, the first being the impact executive director of a rural federally of dialysis interventions on patient qualified mental health clinic, state reported outcomes. The second is medical director and women’s health investigating sleep quality and sleep liaison with the U.S. Department of disorders in patients with chronic kid- Health and Human Services. ney disease with the aim of developing interventions in this at-risk group. He has also worked with community cohorts to describe sleep quality and sleep apnea in the general population and recently completed trials assessing the role of volume overload in the risk of obstructive sleep apnea. Mark Unruh,MD

unm health sciences center 2019 / contracts and grants 25 the university of new mexico health sciences center

Contracts and Grants Office of the Chancellor 27 Office of the Executive Vice Chancellor 27 2019 Center for Infectious Disease & Immunity 27 Institute for Resilience, Health & Justice 27 Memory & Aging Center 27 Office of the Vice Chancellor for Research 27 Animal Research Facility 27 Clinical & Translational Science Center 27 College of Nursing 28 College of Pharmacy 28 College of Population Health 29 School of Medicine 30 Anesthesiology 30 & Molecular Biology 30 Comprehensive Cancer Center 30 Continuing Medical Education 32 Dental Medicine 32 ECHO Institute 32 Emergency Medicine 33 Family & Community Medicine 34 Internal Medicine 35 Molecular Genetics & Microbiology 38 Neurology 39 Neurosciences 39 Neurosurgery 40 Obstetrics & Gynecology 40 Office of the Medical Investigator 41 Orthopaedics & Rehabilitation 41 Pathology 41 Pediatrics 42 Psychiatry & Behavioral Sciences 47 Radiology 48 Surgery 48 Health Sciences Library & Informatics Center 48 Office for Diversity, Equity & Inclusion 48 UNM Hospital 48 UNM Medical Group, Inc. 48

26 unm health sciences center research annual report 2019 OFFICE OF THE CHANCELLOR Center for Infectious Disease Animal Research Facility & Immunity Sheila Hickey Richard Larson Health Resources and Services Thomas Byrd New Mexico VA Health Care System Administration National Institute of Allergy and Infectious Veterinary Services for the NM Veterans Scholarship for Disadvantaged Students - Diseases Affairs Health Care System $29,303 Continuation $650,000 A Mouse Model of Mycobacterium Abcessus Lung Infection That Mimics Human CLINICAL & TRANSLATIONAL Elizabeth Kocher Disease $75,750 SCIENCE CENTER Lynore M. Martinez, M.D., Professional Association Michelle Ozbun Matthew Campen Locum Tenens-Santa Fe OBGYN $25,000 National Institute of Allergy and Infectious National Center for Advancing Diseases Translational Sciences Pueblo of Sandia Biology of Infectious Disease and University of New Mexico Clinical & Locum Tenens- Sandia Inflammation $234,357 Translational Science Center KL2 - Health Clinic $25,000 Continuation $331,150 Terry Wu Presbyterian Healthcare Services Sandia National Laboratories Professional Services $5,000 Mark Garcia CRISPR Nano Delivery $35,000 Duke University A. Robb McLean Institute for Resilience, Health & Spironolactone Initiation Registry Randomized Interventional Trial in New Mexico Department of Health Justice Locum Tenens Program DOH Physician, Heart Failure in Preserved Ejection PA and NP Services $150,000 Andrew Hsi Fraction $51,711 Bernalillo County New Mexico Department of Health Richard Larson ADOBE $988,386 Physician, PA and NP Project - National Center for Advancing Specific Supplement $50,000 Memory & Aging Center Translational Sciences University of New Mexico Clinical & New Mexico Department of Health Janice Knoefel Translational Science Center UL1 - Locum Tenens Program DOH Physician, Virginia Commonwealth University Year 5 $3,759,779 PA and NP Services - Specific (Subaward) Sensor-Based Mobility Supplement $15,413 Assessment of Older Latinos National Center for Advancing Translational Sciences New Mexico Department of Health With Dementia $13,256 Collaboration to Enhance Naloxone Physician, PA and NP Project $10,000 Gary Rosenberg Dispensing in Rural and Underserved National Center for Research Resources Suzanne Popejoy Areas $298,963 MRI and CSF Biomarkers of White Matter City of Albuquerque Injury in VCID $1,109,293 Primary Care/MSW Services University of Nevada, Las Vegas Program $161,970 Institutional Development Award Program OFFICE OF THE VICE CHANCELLOR Infrastructure for Clinical and Translational Steven (Bruce) Williams FOR RESEARCH Research: BERD $242,376 Truman Health Services Provider Agreement - Evergreen $25,000 Richard Larson University of Nevada, Las Vegas Lovelace Respiratory Research Institute Institutional Development Award Program OFFICE OF THE EXECUTIVE LRRI/BSGP Fellowship Agreement Infrastructure for Clinical and Translational VICE CHANCELLOR 2018 $16,788 Research: PDC $138,156

Richard Larson Lovelace Respiratory Research Institute University of New Mexico Foundation LRRI/BSGP Admin Support Agreement Private Gifts for Research 2018 $4,737 (2nd Qtr - FY19) $2,195,146 University of New Mexico Foundation Private Gifts for Research (1st Qtr - FY19) $344,862

University of New Mexico Foundation Private Gifts for Research (4th Qtr - FY19) $295,297 University of New Mexico Foundation Private Gifts for Research (3rd Qtr - FY19) $98,788

unm health sciences center 2019 / contracts and grants 27 National Center for Advancing HRSA/Bureau of Health Professions National Institutes of Health Translational Sciences NSL - Baccalaureate Nursing $182,311 Inhalation of Contaminated Mine Waste Admin Supplement- Advanced Dusts As a Route for Systemic Metal Biomanufacturing of the Bone-Ligament New Mexico Board of Nursing Toxicity $481,610 Interface $74,436 New Mexico Nursing Education Statewide Planning FY19 $11,546 Lovelace Biomedical & Environmental University of Nevada, Las Vegas Research Institute Clinical and Translational Research Janice Martin Porcine Vascular Injury $239,395 Infrastructure Network $60,225 City of Albuquerque Geriatric Education and Health Baylor College of Medicine University of Pittsburgh Maintenance $67,000 Notification of Access to Toxic Effects NCATS Accrual to Clinical Trials of E-cigs Following Transition From Project $37,875 Mountain Spirit Integrative Medicine Conventional Cigarettes $124,368 Mountain Spirit - Heidi Rogers $60,821 University of Nevada, Las Vegas Melanie Dodd Institutional Development Award Program El Centro Family Health First Nations Community Healthsource, El Centro Family Health $60,653 Infrastructure for Clinical and Translational Inc. Research: CEO $17,347 Presbyterian Healthcare Services First Nations Community Healthsource, Inc. $64,685 University of Nevada, Las Vegas Presbyterian Healthcare Services $31,449 Institutional Development Award Program Carolyn Montoya Hospice of New Mexico Infrastructure for Clinical and Translational HRSA/Bureau of Health Workforce Consultant Pharmacist - Hospice of New Research: T&E $13,858 Advanced Nursing Education Workforce Mexico $13,130 Eric Prossnitz Program $653,899 Eszter Erdei Virtici, LLC ideas42 ASCEND: Accelerating Solutions for An Intervention for a Healthy Work-Life Educational Tools for Teaching Environmental Commercialization and Entrepreneurial Balance $5,000 Health Literacy to Nursing Students With a Development in the Mountain West IDeA Focus on Indigenous Populations’ Health and States $300,000 Elizabeth Tigges Well-Being $30,370 Sigma Theta Tau Hengameh Raissy Sigma Theta Tau PSA $100,000 Linda Felton University of Arkansas Biomedical Research Institute of New Data Coordinating and Operations Center COLLEGE OF PHARMACY Mexico for the IDeA States Pediatric Clinical Trials Formulation Development Services $299,160 Network - VDORA $107,737 Joe Anderson New Mexico Department of Health Eunice Kennedy Shriver National Institute University of Arkansas BAA/Heart Disease and Stroke Prevention of Child Health and Human Development Data Coordinating and Operations Center the Program Health Systems Intervention Aqueous-Based Two-Step Spray Drying IDeA - Amendment States Pediatric Clinical Project $55,583 as a Taste-Masking Drug Delivery Trials Network - VDORA $18,309 Platform $227,250 Ludmila Bakhireva Anjali Subbaswamy National Institute on Alcohol Abuse and U.S. Department of Veterans Affairs Duke University Alcoholism Formulation & Batch Records for the VA Dexmedetomidine Opioid-Sparing Effect ENRICH-2: Stress-Reactivity and Self- Medical Center $30,112 in Mechanically Ventilated Children $71,750 Regulation in Infants With Prenatal Alcohol Pamela Hall Exposure $693,579 COLLEGE OF NURSING National Institute of Allergy and Infectious National Institutes of Health Diseases Christine Kasper Epigenetic Markers for Neonatal Abstinence Vaccine-Mediated Control of Bacterial American Association of Colleges of Nursing Syndrome: Mechanistic Insights From an Virulence Regulation and Infection $378,750 All of Us $10,000 Established Birth Cohort $187,566 Joe Hoover MaryJane Lewitt New Mexico Department of Health Diné College El Pueblo Health Service Enhancing Pharmacy-Based Naloxone Livestock Movement and Exposure to El Pueblo Health Contract $58,111 Distribution $122,380 Abandoned Uranium Mine Waste in Cove Wash Watershed $237,079 Judy Liesveld Barry Bleske HRSA/Bureau of Health Workforce University of Michigan Laurie Hudson Nurse Education, Practice, Quality and Genetic Determinants of ACEI Prodrug National Institutes of Health Retention - Veteran Nurses in Primary Activation $26,669 Zinc Chemoprevention of Arsenic Care $392,846 Co-Carcinogenesis $314,363 Matthew Campen Indian Health Service Centers for Disease Control and University of Oklahoma Success in Nursing for Native Americans Prevention Targeting G-CSF Receptor and Tumor- Through Collaboration $337,341 Systemic Health Implications of Occupational Associated Neutrophils in Colon Nanomaterial Exposure $482,356 Cancer $12,756

28 unm health sciences center research annual report 2019 Denver Health and Hospital Authority Researched Abuse, Diversion and Addiction- Related Surveillance System Work Order #12 $17,185 U.S. Consumer Product Safety Commission New Mexico Carbon Monoxide Safety $2,500 Denver Health and Hospital Authority Researched Abuse, Diversion and Addiction- Related Surveillance System Work Order #13 $1,562

Traci White Memorial Medical Center Pharmacist Clinician for Inpatient Consult Team - Continuation $44,200 Johnnye Lewis Debra MacKenzie Memorial Medical Center National Institutes of Health Duke University Pharmacist Clinician for Inpatient Consult Understanding Risk Gradients From Using Silicone Wristbands As Non-Invasive Team $42,016 Environment on Native American Child Passive Environmental Monitors to Evaluate Health Trajectories $4,250,620 Seasonal and Within-Family Correlation for Mesilla Valley Hospice

Environmental Exposures $10,175 Mesilla Valley Hospice Pharmacist Clinician National Institute of Environmental Health Services Agreement $39,394 Sciences Renee-Claude Mercier UNM Metal Exposure Toxicity Assessment New Mexico Department of Health Katherine Zychowski Bufford on Tribal Lands in the Southwest Superfund Antimicrobial Stewardship Project $69,600 National Institute of Environmental Health Research Program $1,280,213 Pavan Muttil Sciences National Institute of Environmental Health Lynntech, Inc. Neurovascular Consequences of Inhaled Sciences An Inhaled Clofazimine Formulation for Uranium Mine-Site Dust Exposure $85,401 Center for Native American Environmental the Treatment of Tuberculosis $42,265 Health Equity Research $700,000 COLLEGE OF POPULATION Lynntech, Inc. HEALTH National Institutes of Health An Inhaled Clofazimine Formulation for the Understanding Risk Gradients From Treatment of Tuberculosis $20,000 William Athas Environment on Native American Child New Mexico Department of Health Health Trajectories $499,650 Lynntech, Inc. An Inhaled Clofazimine Formulation for the Technical Enhancement and Application U.S. Environmental Protection Agency Treatment of Tuberculosis $750 Project $57,425 Center for Native American James Nawarskas Lisa Cacari Stone Environmental Health Equity Research - National Institute on Minority Health and Continuation $300,000 American Association of Colleges of Pharmacy Health Disparities Duke University Comparison of Standardized Patient FY20 TREE Center for Advancing Behavioral Health $1,404,730 Attentional Mechanisms Underlying of Assessment of Communication Skills in Information Processing in a Sample of Pharmacy and Medical Students $3,621 National Institute on Minority Health and Navajo Children $61,224 Health Disparities Melissa Roberts U.S. Environmental Protection Agency Analysis Group, Inc. TREE Center for Advancing Behavioral Health Center for Native American Environmental GSK Global Exacerbation Study $1,800 - AD/ADRD Specific Supplement $378,738 Health Equity Research $50,000 Jay Simon Alexis Handal National Institutes of Health DaVita Inc. National Institute of Environmental Health Externship Supplement for UNM Metal DaVita Pharmaceutical Services $90,000 Sciences Exposure Toxicity Assessment on Tribal Lands Maternal Ethylenethiourea Levels, in the Southwest P42ES025589 $10,536 Sandia National Laboratories Newborn Thyroid Function and Infant SNL Isotopes Request $4,375 Development $490,444 Jim Liu National Institutes of Health Susan Smolinske National Institute of Environmental Health Arsenic, GATA-1, and Hemato- Health Resources and Services Sciences toxicity $340,875 Administration Maternal Ethylenethiourea Levels, Newborn Poison Control Stabilization and Thyroid Function and Infant Development - University of Louisville Enhancement Program $120,802 Diversity Supplement $83,740 Particulate Cr(VI) Toxicology in Human Lung Epithelial Cells and Fibroblasts $40,513

unm health sciences center 2019 / contracts and grants 29 Morgan State University University of Texas at El Paso A Student-Centered Entrepreneurship BUILDing SCHOLARS - Continuation $54,083 Training Program to Increase the Diversity of the Biomedical Workforce $48,552 Nikki Jernigan National Heart, Lung, and Blood Institute Anonymous Non-Profit Foundation The Role of the Acid-Sensing Io Channel 1 in Family Listening Program - Capacity the Systemic Vasculature $33,071 Building Mini Conference $760 National Heart, Lung, and Blood Institute SCHOOL OF MEDICINE R01 Renewal Vascular Smooth Muscle Function in Pulmonary Anesthesiology Hypertension $378,750 Eugene Koshkin Nancy Kanagy Medtronic Exhalix, LLC UNM Pain Medicine Fellowship FY18-19: Non-Invasive Detection of PAD $530,018 Medtronic $20,000 Nora Perrone-Bizzozero Medtronic National Cancer Institute UNM Pain Medicine Fellowship FY19-20: Cold-Inducible RNA Binding Protein Links Medtronic $20,000 Inflammation and Breast Cancer $30,019 Rebecca Rae ANAV Tribal Health Clinic - Quartz Valley John Rask Thomas Resta Indian Reservation Vanderbilt University Medical Center National Institutes of Health QVIR Evaluation for Youth & Family Tree Simulation Multicenter Project $29,449 Minority Institutional Research Training Project $99,978 Program (T32) $382,142 Karin Westlund-High Santa Clara Pueblo National Institute of Dental and National Institutes of Health Kha’po Owingeh RezRIDERS Project $79,159 Craniofacial Research Vascular Smooth Muscle Signaling in Scfv Antibody Therapy for Chronic Intermittent Hypoxia-Induced Pulmonary Francisco Soto Mas Trigeminal Neuropathic Pain $240,500 Hypertension $378,750 University of Texas Health Center at Tyler Health, Safety and Psychosocial Organic Biochemistry & Molecular Biology National Heart, Lung, and Blood Institute Farming Survey $93,948 Diversity Supplement Minority Institutional Oscar Bizzozero Research Training Program (T32) $7,565 Bernalillo County National Multiple Sclerosis Society Bernalillo County Senior Services Prophylactic and Therapeutic Effects of Comprehensive Cancer Center Project $25,000 Liproxstatin-1 in EAE $55,000 Sarah Adams McKinley County Amy Gardiner National Cancer Institute McKinley County Project $31,640 National Institute on Alcohol Abuse and Mechanisms of Selective Therapeutic Synergy

Alcoholism of PARP-Inhibition and CTLA4 Blockade McKinley County The Role of Mir-150 in Regulating Engaged by Interferon-gamma in the McKinley County Project $23,730 Angiogenesis During Prenatal Alcohol Ovarian Tumor Microenvironment $361,703 Kristine Tollestrup Exposure $217,781 Leslie Andritsos Health Resources and Services Laura Gonzalez-Bosc The SASS Foundation and Hairy Cell Administration American Heart Association (Southeast Leukemia Foundation New Mexico MCH Public Health Training Affiliate) Development of a Novel Scoring System Institute $168,284 for the Diagnosis and Disease Monitoring Novel Collagen V-Reactive Natural of Classic and Variant Hairy Cell Tulane University TH17 Cells in Hypoxic Pulmonary Leukemia $100,000 ACA - Public Health Training Hypertension $300,000 Centers $34,400 Department of the Navy Cecilia Arana Yi New Mexico Cancer Care Alliance Nina Wallerstein Biomarkers of Hypoxia Exposure $202,824 Clinical Trial Phase 2 $120,048 National Institutes of Health Department of the Navy Advancing CBPR Practice Through a Biomarkers of Hypoxia Exposure $52,824 Jessica Belmonte Collective Reflection and Measurement New Mexico Cancer Care Alliance Toolkit $479,541 Helen Hathaway Clinical Trial $93,640

National Cancer Institute Columbia University Is Tumor-Adjacent Histologically Normal Marianne Berwick An Experimental Investigation Into the Tissue Primed for Tumorigenesis? $303,617 National Cancer Institute Impact of Socioeconomic Context on Integration of Clinical and Molecular Biological Markers of Aging, Health and National Cancer Institute Biomarkers for Melanoma Mortality $56,982 Is Tumor-Adjacent Histologically Normal Survival $1,944,358

Tissue Primed for Tumorigenesis? $67,096

30 unm health sciences center research annual report 2019 National Cancer Institute in Ethnically and Geographically Diverse Thomas Schroeder Genomic Evaluation of the Female Survival Cancer Survivors $423,939 New Mexico Cancer Care Alliance Advantage in Melanoma $75,897 Clinical Trial Phase 3 $40,500 Carolyn Muller National Cancer Institute National Cancer Institute Larry Sklar Genomic Evaluation of the Female Survival Community Oncology Research Program Leidos, Inc. Advantage in Melanoma $74,384 Minority/Underserved Community Sites BASE Project: NCI Experimental Therapeutics (UM1) $1,263,252 Chemical Biology Consortium $280,000 Cynthia Blair National Cancer Institute NRG Oncology Leidos, Inc. Improving Physical Functioning in Older NRG Oncology Foundation: National Clinical WDR5 Project: NCI Experimental Cancer Survivors Through Light-Intensity Trials Network and NCI Community Oncology Therapeutics Chemical Biology Physical Activity $154,415 Research Program (Federal) $718,644 Consortium $270,000

Rutgers, The State University of NRG Oncology Leidos, Inc. NRG Oncology Foundation: National Clinical WDR5 Project: NCI Experimental Project HERO $129,233 Trials Network and NCI Community Oncology Therapeutics Chemical Biology Research Program (Non-Federal) $718,644 Consortium $120,000 Ursa Brown-Glaberman New Mexico Cancer Care Alliance National Cancer Institute Leidos, Inc. Clinical Trial Phase 3 $107,080 Community Oncology Research Program LDHA Project: NCI Experimental Therapeutics Minority/Underserved Community Sites Chemical Biology New Mexico Cancer Care Alliance (UM1) $528,484 Consortium $92,000 Clinical Trial Phase 2 $97,480 New Mexico Cancer Care Alliance Heloisa Soares Matthew Fero Clinical Trial Phase 2 $103,880 New Mexico Cancer Care Alliance University of Washington Clinical Trial Phase 1/2 $116,680 Systems and Carcinogenic Impact New Mexico Cancer Care Alliance Assessment of Topical Microbicides on Clinical Trial Phase 2b $103,880 New Mexico Cancer Care Alliance Human Mucosa - Continuation Clinical Trial Phase 3 $116,680 Year 5 $125,853 New Mexico Cancer Care Alliance Clinical Trial Phase 2 $103,880 New Mexico Cancer Care Alliance Dolores Guest Clinical Trial Phase 2A $109,640 Consulate of Mexico in Albuquerque NRG Oncology Dana Farber Cancer Institute Ventanilla De Salud 2019 $36,000 NRG Member Site Support $15,000 Project 2: EL CENTRO: Engaging Latinos Consulate of Mexico in Albuquerque Scott Ness in the CENter of Cancer TReatment Ventanilla De Salud - Specific National Institutes of Health Options $15,150 Supplement $10,000 Mutations and Target Genes ACC - Yr2- FY19 $359,813 Alan Tomkinson Yan Guo National Institute of General Medical Indiana University Adenoid Cystic Carcinoma Research Sciences The Role of LMO2 in the Pathogenesis of Foundation Cellular Functions of Eukaryotic DNA T-cell Leukemia $10,049 RNA-Sequencing - LG Cohort of ACC Ligases $395,252 Samples $137,629 Richard Harvey National Institute of Environmental Health National Cancer Institute Eric Prossnitz Sciences Integration of Gene Expression Patterns, National Cancer Institute Roles of Lig3 and XRCC1 Genes in Genome GPER & Breast Carcinogenesis (3) $353,942 Fusions, Mutations, Cytogenetics and Other Stability $375,660 Clinical Variables for Subtyping Leukemias National Cancer Institute National Institute of Environmental and Targeting Therapies $154,500 Molecular Mechanisms & Apps of ER/GPER Health Sciences Ligands - FY19 Continuation $320,000 Richard Lauer Lig3 and XRCC1 Genes in Genome New Mexico Cancer Care Alliance Stability $307,800 Dialysis Clinic, Inc. Clinical Trial Phase 2 $103,230 GPER Kidney Disease Renewal $192,100 Lovelace Respiratory Research Institute New Mexico Cancer Care Alliance DNA Repair-Lung Disease-LRRI $74,883 Linnaeus Therapeutics Clinical Trial Phase 1b/2 $90,430 SBIR-Linnaeus Therapeutics/g-1 Enantiomer Lawrence Berkeley National Laboratory Subaward $60,000 American Cancer Society Structural Cell Biology of DNA Repair Transportation Plan for UNM Cancer New Mexico State University Machines Project $66,600 Center $5,000 New Mexico (INBRE) Specific Supplement - Charles Wiggins Jean McDougall Amendment #13 $2,416 National Cancer Institute Rutgers, The State University of New Jersey Ian Rabinowitz Surveillance Epidemiology and End Results Comparative Effectiveness of Interventions to Takeda Pharmaceuticals North America, Inc. Program $2,697,259 Increase Guideline-Based Genetic Counseling Professional Services Agreement $9,000

unm health sciences center 2019 / contracts and grants 31 New Mexico Department of Health Breast and Cervical Cancer Surveillance Project $6,330

Cheryl Willman National Cancer Institute University of New Mexico Cancer Center Support Grant $2,246,011

National Cancer Institute Dissemination of a Colorectal Cancer Screening Program Across American Indian Communities in Southern Plains and Southwest United States $300,000

National Cancer Institute Developing and Maintaining a Web- Continuing Medical Education Health Resources and Services Based Source of Cancer Surveillance Administration Kathy Breckenridge Data for American Indians and Alaska South Central AIDS Education and Training Richard Wolf Medical Instruments Natives $293,284 Center Program $3,041,653 Corporation National Cancer Institute Endoscopic Spine Health Conference $7,500 Robert Wood Johnson Foundation

University of New Mexico Cancer Center ECHO-RWJF Partnership for National KARL STORZ Endoscopy-America, Inc. Support Grant - Tobacco Cessation Health $2,000,000 Endoscopic Spine Health Conference $7,500 Supplement $250,001 New Venture Fund National Cancer Institute Dental Medicine ECHO/Co-Impact Partnership for Achieving Cancer Health Disparities Regional Global Scale $1,412,761 Gary Cuttrell Training Network (GMaP) $241,885 New Mexico Higher Education Defense Health Agency National Cancer Institute Department Telementoring Services Defense Health Women in Survivorship Healthcare: Creation Training Dentists to Treat Pedictric Agency $782,611 Patients $900,000 of a Rural Cancer Survivorship Program Accreditation Council for Graduate Using Project ECHO $200,000 Office of Rural Health Policy Medical Education National Cancer Institute Postdoctoral Training in General, Pediatric ACGME Patient Safety - Quality Expand NCI-Supported Community and Public Health Dentistry and Dental Improvement Programming $315,000 Hygiene $500,000 Outreach Capacity Through Community Jhpiego Corporation Health Educators of National Outreach New Mexico Department of Health Jhpiego Healthcare Workforce $200,000 Network $125,000 Basic Oral Health Services $102,355 New Mexico Corrections Department National Cancer Institute Office of Rural Health Policy New Mexico Corrections Department Continuing Umbrella Research Special Needs Dental Residency Training Hepatitis C $190,644 Experience $113,625 Program $65,000 New Mexico Department of Health Cowboys for Cancer Research New Mexico Department of Health Hepatitis C and HIV Clinical Consultant Cowboys for Cancer Research $89,816 Basic Oral Health Services - Specific Project - (Multi-Year) $179,772 Supplement $4,000 National Cancer Institute Bernalillo County Cancer Clinical Investigator Team Melissa Ivers Bernalillo County Re-Entry ECHO/CHW Leadership Award $60,000 HRSA/HIV-AIDS Bureau Training w/BAA $150,000

Brigham and Women's Hospital HRSA Ryan White Part F $285,682 Co-Impact Biomarker, Imaging and Quality of Life HRSA/HIV-AIDS Bureau Co-Impact Strategic Planning Studies Funding Program - Specific HRSA Ryan White Part F $285,682 Support $150,000 Supplement $40,181 ECHO Institute New Mexico Department of Health Bridget Wilson New Mexico DOH Tuberculosis Project National Institute of General Medical Sanjeev Arora ECHO FY19 $150,000 Sciences Leona M. and Harry B. Helmsley Center for the Spatiotemporal Modeling Charitable Trust Seattle Indian Health Board of Cell Signaling $2,463,519 Helmsley Charitable Trust for Global Project ECHO Supporting the Enhanced Replication Support $3,750,000 Implementation of Health and Wellness $150,000

32 unm health sciences center research annual report 2019 New Mexico Department of Health University of Kentucky Department of the Air Force New Mexico First Responder ECHO Partnership With the University of Kentucky UNM Educational Service Agreement Program $115,000 and Gilead for Quality HCV Care - FY19 $518,760 Continuation $25,000 Northwest Portland Area Indian Health City of Albuquerque Board Region IX Education Cooperative Medical Directorship $406,250 Indian Health Services TeleECHO Clinic New Mexico Public Education Department Support $100,000 Education ECHO $20,000 Department of the Air Force UNM Educational Service Albuquerque Area Indian Health Board, Inc. Four Seasons Agreement $389,070 Leveraging Project ECHO for a Four Seasons Palliative Care Grant $12,500

Comprehensive Approach to Health and City of Albuquerque Indiana University Wellness in Indian Country $94,500 Professional Services- Medical Indiana PEP Program $8,000 Directorship $187,500 American Institutes for Research Northwest Portland Area Indian Health Bernalillo County Fire Department AIR Medication-Assisted Treatment - Board Continuation Yr 3 $94,350 Medical Directorship $63,053 Support for Endocrinology Pilot $7,560 State of New Mexico Albuquerque Area Indian Health Board, Inc. Emergency Medicine Tribal Epidemiology Centers $85,000 Medical Directorship for TEMS Danielle Albright Program $55,000 Seattle Indian Health Board New Mexico Crime Victims Reparation Project ECHO Supporting the Enhanced City of Albuquerque Commission Implementation of Health and Professional Services Agreement $50,000 Coordination of the Domestic Violence Death Wellness $75,000 Review Team $96,000 Department of the Air Force American Society of Addiction Medicine UNM Educational Service Justin Baca FAME Clinic $70,001 Agreement $48,000 Abbott Point of Care Inc. Tanzania Health Promotion Support CS-2018-011 Clinical Evaluation of the I-STAT Department of the Air Force Leveraging the ECHO Model to Improve Ionized Calcium and Lactate Tests in Venous UNM Educational Service Agreement Lab Services in Tanzania $57,890 and Arterial Specimens $140,848 FY19 $48,000

Department of the Air Force New Mexico Department of Health Abbott Laboratories Inc. UNM Educational Service Agreement TB Border Health $50,000 CS-2017-0006: Clinical Evaluation of the FY19 $48,000 I-STAT System for Hematocrit in Venous Bernalillo County and Arterial Specimens $85,296 Department of the Air Force Bernalillo County Re-Entry ECHO UNM Educational Service Agreement PHASE 2 $35,000 Abbott Laboratories Inc. FY19 $48,000 CS-2017-0007 Clinical Evaluation of I-STAT Health Research Inc. PTplus/aPTT Cartridge for APTT in Subjects ECHO Partnership for Quality Improvement Western Refining Southwest, Inc. Receiving Heparin Therapy $81,316 Medical Directorship $33,000 Innovations in HIV Care $31,500

Abbott Laboratories Inc. Laura and John Arnold Foundation Sandoval County Regional Emergency CS-2017-0007 Clinical Evaluation of I-STAT Impact of Opioid ECHO Programs on Communications Center PTplus/aPTT Cartridge for APTT in Subjects Health and Health Care - Specific Medical Director Services $28,368 Receiving Heparin Therapy $3,519 Supplement $30,230 Wilderness Medics Inc Laura Banks African Society for Laboratory Medicine Medical Director $25,000 New Mexico Department of ECHO Institute Collaboration With the Transportation County of Bernalillo African Society of Laboratory Medicine - Pedestrian Safety Initiative $300,000 Professional Services $19,999 Continuation $30,000

New Mexico Department of Health K&I Field Services New Mexico Department of Health Hospital and Health Systems Medical Direction and Care $12,500 Anti-Microbial Stewardship $27,003 Preparedness $99,698 Kirtland Air Force Base New Mexico Department of Health New Mexico Senior Olympics Paramedic Training Program - New Mexico DOH Sponsorship of NM National Senior Games $12,000 119PAR006 $8,500 AETC Conference $25,000

Darren Braude National Park Service University of Kentucky Department of the Air Force Zion National Park BLS Refresher $7,250 Partnership With the University of Kentucky UNM Educational Service and Gilead for Quality HCV Care $25,000 Village of Angel Fire Agreement $518,760 Medical Directorship $6,000 New Mexico Department of Health Department of the Air Force New Mexico DOH - Tuberculosis Project Motion Picture Set Medics, LLC UNM Educational Service Agreement ECHO FY2019 $25,000 Motion Picture Set Medics, LLC $2,640 FY19 $518,760

unm health sciences center 2019 / contracts and grants 33 Kirtland Air Force Base CE Package Course - August $2,460

Kirtland Air Force Base CE Package Course - May $1,775

Sandia Crest Marathon Medical Directorship $1,550

Kirtland Air Force Base 2018 CE Package Course 009 $1,175

Quick Draw Medical Directorship $880 Joy Crook New Mexico Department of Health NM DOH Statewide EMS Project $50,000 Jon Kenneth Femling Yes Biotechnology Inc. The Mind Research Network Nationwide Children's Hospital Pilot Study of Strepic Device for the The Impact of Diffuse Mild Brain Injury on C-Spine $60,300 Diagnosis of Group a Streptococcal Clinical Outcomes in Children $79,544 Pharyngitis $205,500 Philip Seidenberg

University of Michigan Siemens Healthcare Diagnostics, Inc. Sandia National Laboratories RNA Biosignatures: A Paradigm Change for Specimen Collection in the Emergency Rim-to-Rim Continuation 2018-2019 the Management of Young Febrile Infants Department for the Assessment of Clinical Yr 3 $55,740 (Phase 1) $10,551 Performance of the Siemens PBNP Assay/ Duke University centaur-201806 $392,264 Aaron Reilly Multi-Center, Randomized, Open-Label Trial Trans-Pecos Ultra Isaac Tawil to Evaluate the Efficacy of Oral Fosfomycin Medical Directorship $2,000 DCI Donor Services Versus Oral Levofloxacin Strategies in Medical Directorship Services $19,777 Complicated Urinary Tract Infections $8,000 Robert Sapien Olive View Medical Center-UCLA Health Resources and Services Chelsea White EMERGEncy IDnet:Emergency Department Administration Pueblo of Laguna Fire Protection Program Sentinel Network for Surveillance of Emerging Child Ready: Expanding a Novel Community Laguna Pueblo Medical Direction $80,000 Self-Assessment Approach to Regionalization Infections $6,000 Ramah Navajo School Board,Inc, dba (EMSC Demonstration Grants) $200,000 Olive View Medical Center-UCLA Pine Hill Health Center EMERGEncy IDnet:Emergency Department University of Arizona Medical Directorship for Ramah Navajo Sentinel Network for Surveillance of Emerging EMSC: Pediatric Emergency Care Applied School Board, Inc. Pine Hill, New Mexico w/ Research Network $154,263 BAA - Continuation $45,000 Infections $1,000 Andrew Harrell HRSA/Maternal and Child Health Bureau Pueblo of Acoma EMS National Park Service EMSC Partnership Grants $130,000 Acoma Pueblo EMS Medical Directorship W/

Grand Canyon Medical Direction $36,000 BAA - Continuation $36,000 HRSA/Maternal and Child Health Bureau Department of the Air Force EMSC Partnership Grants - PECC Learning Cibola County Nellis Air Force Base PJ Refresher $18,400 Collaborative $100,000 Medical Directorship $12,000

National Park Service Health Resources and Services Jenna White Grand Canyon National Park - EMS Medical Administration Pueblo of Jemez Services - Continuation $6,000 Child Ready: Expanding a Novel Community Pueblo of Jemez Medical Direction Self-Assessment Approach to Regionalization 2018 $20,000 Steven McLaughlin (EMSC Demonstration Grants) $94,700 New Mexico State Fair Town of Cochiti Lake Health Resources and Services Medical Director Services $7,500 Emergency Medical Services & Directorship $53,983 Administration Child Ready: Expanding a Novel Community Family & Community Medicine Taos County Self-Assessment Approach to Regionalization Antoinette Benton Medical Directorship $36,000 (EMSC Demonstration Grants) $93,704 New Mexico Department of Health Grace (Joo-Hee) Park Health Resources and Services Transdisciplinary Evaluation and Support The Mind Research Network Administration Clinic - FY19/MSU $501,493

The Impact of Diffuse Mild Brain Injury on EMS for Children State Partnership Falling Colors Corporation Clinical Outcomes in Children $84,252 Grant $68,445 FY20 Pre-Administration Screening and Resident Review $194,569

34 unm health sciences center research annual report 2019 Falling Colors Corporation Janet Page-Reeves Internal Medicine Pre-Administration Screening and Resident EleValle Review - FY19 $127,000 FY20 Ele Valle Evaluation Services $9,375 Christos Argyropoulos Sentien Biotechnologies Inc. Nancy Pandhi New Mexico Department of Health SBI-101-01: A Multicenter, Randomized, Sham- Wisconsin Partnership Program Transdisciplinary Evaluation and Support Controlled, Double-Bllind, Ascending-Dose Experience-Based Co-Design Catalyst Film Clinic - FY19 $43,238 Study of Extracorporeal Mesenchymal Stromal Project $39,028 New Mexico Department of Health Cell Therapy (SBI-101 Therapy) in Subjects Transdisciplinary Evaluation and Support Oregon Health & Science University With Acute Kidney Injury Receiving Continuous Oregon Clinical and Translational Research Renal Replacement Therapy $111,360 Clinic - FY19/MSU $13,293 Institute: Experiences With Pediatric Dialysis Clinic, Inc. Marlene Ballejos Cancer $15,137 American Association of Medical Colleges 2018 East by Southwest Nephrology Tassy Parker Conference $21,089 AAMC Funding $18,750 University of Colorado Denver Dialysis Clinic, Inc. Laura Chambers-Kersh Collaborative Hubs to Reduce the Burden of TRILO2GY Start Up Payment $870 University of California, San Francisco Suicide Among American Indian & Alaska Mozambique Family Medicine Native Youth $135,532 Cristian Bologa Position $30,227 Givaudan Flavors Corporation Washington State University Givaudan Research Agreement - Jennifer Hettema Native-Controlling Hypertension and Risks Year 11 $205,000 Health & Human Services/Office Through Technology $57,338 of the Secretary Steven Bradfute University of Colorado Health Sciences FY20 Prevention of Teen Pregnancy Albert Einstein College of Medicine Center Through Screening and Brief Intervention Prometheus: A Platform for Rapid Center for American Indian and Alaska in Primary Care $1,000,000 Development of Immunotherapeutics and Native Health Disparities $29,682 Immunoprophylactics Against Emerging Health & Human Services/Office Viral Threats $318,150 of the Secretary University of Colorado Denver Prevention of Teen Pregnancy Through NIDDK-Funded Center for American Indian Defense Threat Reduction Agency Screening and Brief Intervention in and Alaska Native Diabetes Translation Effects of Differential Gycosylation on Primary Care $939,000 Research $18,805 Filovirus Glycoprotein Immunogenicity $299,784 Arthur Kaufman Washington State University City of Albuquerque Native-Controlling Hypertension and Risks Los Alamos National Laboratory Intensive Case Management FY19 $750,000 Through Technology $6,489 Immunogenicity of Delayed Antigen

Release Systems $100,000 Presbyterian Healthcare Services David Rakel Presbyterian Healthcare Contract for Presbyterian Medical Services Defense Threat Reduction Agency Professional Services $27,000 Services $232,586 Effects of Differential Gycosylation on Filovirus Glycoprotein New Mexico Department of Health First Choice Community Healthcare Professional Services $23,000 Immunogenicity $92,286 New Mexico Immunization Coalition - FY19 $137,787 First Choice Community Healthcare Marcos Burgos Professional Services Agreement $1,106 New Mexico Department of Health Sarah Lathrop Tuberculosis Medical Care, Consultation New Mexico Department of Health Robert Rhyne and Education Services $390,000 New Mexico Emerging Infections Program - New Mexico Department of Health FY20 $570,333 Academic Detailing Project FY19 $98,115 Kelly Chong Dialysis Clinic, Inc. New Mexico Department of Health Valerie Romero-Leggott Risk Factors of 30-Day Re-Hospitalization New Mexico Emerging Infections Program - HRSA/Bureau of Health Workforce Among Patient Receiving Inpatient Dialysis: FY19 $434,922 National HCOP Academies $639,840 Towards Inpatient Care Quality

New Mexico Department of Health Helene B Silverblatt Improvement $421,290 New Mexico Emerging Infections Program - HRSA/Bureau of Health Workforce Stacey Clegg FY18 $221,354 Area Health Education Centers Rutgers, The State University of New Jersey Program $309,000 Marnie Lyyn Nixon Myocardial Ischemia and Transfusion - Project Concern International HRSA/Bureau of Health Workforce CCC $10,000 NM CoIIN $52,000 Area Health Education Centers Osman Dokmeci Program $74,407 AbbVie Orrin Myers M18-891: A Phase 3 Randomized, Placebo- National Park Service Robert Williams Controlled, Double-Blind Study to Evaluate FY20 Statistical Analyses of Restoration Health Resources and Services Upadacitinib in Adolescent and Adult Monitoring Programs in the Jemez Administration Subjects With Moderate to Severe Mountains of Northern New Mexico $19,338 Transforming Primary Care in Under-Served Communities $247,690 Atopic Dermatitis $481,266

unm health sciences center 2019 / contracts and grants 35 Olga Kovbasnjuk University of Maryland, Baltimore County Pathogenesis of E. Coli and Shigella Infections in Human Enteroid Models $204,139

Baylor College of Medicine Intestinal Stem Cell Response to Infection $79,604

University of Washington A Microphysiological System for Kidney Disease Modeling and Drug Efficacy Testing $37,875

Samuel Lee U.S. Department of Veterans Affairs Suzanne Emil Julie In IPA - Stella Jubay $11,356 Iqvia National Institute of Diabetes and Lana Melendres-Groves IFX-1-P2.6: A Randomized, Double-Blind, Digestive and Kidney Diseases Pharmaceutical Research Assoc. Placebo-Controlled, Multicenter, Parallel- Human Enteroids As a Model of Host- Clinical Trial - Phase 4 $157,824 Group Phase 2 Study to Investigate the EHEC Interactions $152,388 Safety and Efficacy of IFX-1 in Subjects Lung Biotechnology PBC National Institute of Diabetes and With Granulomatosis With Polyangiitis and RIN-PH-304: Phase 3, Randomized, Placebo- Digestive and Kidney Diseases Microscopic Polyangiitis $156,608 Controlled, Double-Blind, Adaptive Study to Human Enteroids As a Model of Host- Evaluate the Safety and Efficacy of Inhaled Mark Garcia EHEC Interactions $86,614 Treprostinil in Patients With Pulmonary Duke University Hypertension Due to Chronic Obstructive Care Optimization Through Patient and National Institute of Diabetes and Digestive and Kidney Diseases Pulmonary Disease $140,800 Hospital Engagement Clinical Trial for Heart Human Enteroids As a Model of Host- Failure - Y2 $103,200 Reata Pharmaceuticals Inc. EHEC Interactions $109 Protocol 402-c-1504: A Study of the Efficacy Melissa Gonzales and Safety of Bardoxolone Methyl in Patients Utah State University Saeed Kamran Shaffi With Connective Tissue Disease-Associated Harm Reduction Curricula for Substance Alnylam Pharmaceuticals Inc. Protocol ALN-LECT2-NT-001: A Study Pulmonary Arterial Hypertension $123,672 Use $18,362 of the Natural History of Leukocyte Arena Pharmaceuticals Inc Michelle Harkins Chemotactic Factor 2 Amyloidosis APD811-301: A Study EVAluatiNg the Cystic Fibrosis Foundation (ALECT2) Disease $166,400 Efficacy and Safety of Ralinepag to Improve Cystic Fibrosis Care Center Program $65,090 Patricia Kapsner Treatment OUTCOMES in PAH Theresa Heynekamp Cortendo AB Patients $115,200

Zambon Protocol COR-2017-OLE: An Open-Label Complexa PROMIS II - A Double-Blind, Placebo- Extension Study of Levoketconazole CXA-10-301: Phase 2 Multicenter, Double- Controlled, Multi-Center Clinical Trial (2s,4r-ketoconazole) in the Treatment of Blind, Placebo-Controlled, Efficacy, Safety to Investigate the Efficacy and Safety Endogenous Cushing's Syndrome $57,600 and Pharmacokinetic Study of Two Doses of 24 Months of Therapy With Inhaled of CXA-10 on Stable Background Therapy Colistimethate Sodium in Treatment Novo Nordisk, Inc. in Subjects With Pulmonary Arterial of Subjects With Non-Cystic Fibrosis Clinical Trial Agreement Phase 3 - Y6 $34,456 Hypertension $114,944 Bronchiectasis $160,000 Arena Pharmaceuticals Inc. Michelle Iandiorio Denece Kesler APD811-303: A Study EVAluatiNg the Health Resources and Services HRSA/Bureau of Health Workforce Long-Term Efficacy and Safety of Ralinepag Administration Preventive Medicine Residency Program - in Subjects With PAH Via an Open-Label Comprehensive HIV Early Intervention Y2 $399,992 EXTENSION $102,400 Services (Ryan White Part C) $718,561 HRSA/Office of Rural Health Policy United Therapeutics Corporation New Mexico Department of Health Radiation Exposure Screening Education Phase 1 Clinical Trial: Inhaled Treprostinil HIV Provider Agreement Program $242,525 in Subjects With Pulmonary w/BAA $709,215 Johns Hopkins University Hypertension $57,600 HRSA/HIV-AIDS Bureau Development of a Medical Screening Ryan White HIV/AIDS Program Part D Program for Former LANL & Sandia Gregory Mertz Coordinated HIV Services and Access to Workers $5,000 Metabiota Prevalence of Crimean Congo Hemorrhagic Research for Women, Infants, Children, Miriam Komaromy Fever Virus and Hantaviruses in Ukraine and Youth $466,950 American Society of Addiction Medicine and the Potential Requirement for ASAM/FAME $177,705

36 unm health sciences center research annual report 2019 Differential Diagnosis of Suspect University of California, San Francisco National Institute of Diabetes and Leptospirosis Patients $30,161 STI-CTG $28,980 Digestive and Kidney Diseases Diabetes Prevention Program (DPPOS)- Larissa Myaskovsky Vernon Pankratz Phase 3 $27,095 University of Pittsburgh Dialysis Clinic, Inc. Increasing Equity in Transplant Professional Services Agreement - Case Western Reserve University Evaluation and Living Donor Kidney Biostatistician Services $52,606 Effects of Biomedical Risk Factors on Neuro- Transplantation $87,929 Cognition Using MRI: Long-Term Follow-Up Douglas Perkins of the Diabetes Control & Complications Dialysis Clinic, Inc. National Institute of Allergy and Infectious Trial/Epidemiology of Diabetes Interventions No-Shows for Kidney Transplant Evaluation Diseases & Complications Study Phase 4 $12,845 Study $37,901 Defining the Inflammation and Immunity Transcriptome in Severe Malarial Anemia for Case Western Reserve University University of Pittsburgh Immunotherapeutic Discovery - Y2 $716,070 Effects of Biomedical Risk Factors on Neuro- Cardiac Resynchronization in the Elderly: Cognition Using MRI: Long-Term Follow-Up Piloting Pacemaker vs. Defibrillator John E. Fogarty of the Diabetes Control & Complications Therapy $14,836 International Center for Advanced Study Trial/Epidemiology of Diabetes Interventions in the Health Sciences & Complications Study Phase 4 $12,205 Yue-Harn Ng Training and Research on Severe Malarial Dialysis Clinic, Inc. Anemia $267,968 Case Western Reserve University Kidney: To Take or Not to Take? $249,186 Effects of Biomedical Risk Factors on Neuro- Harvard School of Public Health Dialysis Clinic, Inc. Cognition Using MRI: Long-Term Follow-Up Fogarty Global Health Training Fellowship of the Diabetes Control & Complications Adherence in Kidney Transplant Study $47,292 Program $42,130 Trial-Epidemiology of Diabetes Interventions & Tudor Oprea Complications Study Phase 4 - 19-20 $7,831 Los Alamos National Laboratory National Institutes of Health Diagnostics for Pediatric Knowledge Management Center for Case Western Reserve University Tuberculosis $40,000 EDIC Skeletal Heath Study (SSY8) $5,555 Illuminating the Druggable Genome $1,000,000 Surya Pierce University of South Florida

The Bell Group, Inc. Professional Services: Type I Diabetes Trialnet $650 National Institutes of Health UNM Center for Life $12,000 Machine Learning Model Validation for University of South Florida AD/ADRD $378,750 Fares Qeadan Type I Diabetes Trialnet $310 Albuquerque Area Indian Health The Jackson Laboratory Board, Inc. Melissa Schiff Illuminating the Druggable Genome by Indian Tribal Health Data in the Southwest New Mexico Governor's Commission Knowledge Graphs $121,200 Region: Transformation, Management and on Disability University of Copenhagen Analyses $116,358 Incidence Rates of TBI in New Mexico $35,000 Visiting Scientist Agreement $52,875 Albuquerque Area Indian Health Mark Sheldon East Carolina University, Brody School Board, Inc. of Medicine Large Tribal Health Data in the Southwest U.S. Department of Veterans Affairs Ligand Specificity in Human Glucose Trans- Region: Transformation, Management and Interventional Cardiology Services at porters GLUT1-5 and GLUT9 - Y2 $50,607 Analyses $37,432 the VA $408,161

David Schade Akshay Sood University of North Carolina A Collaboration for the NIH Data George Washington University National Institutes of Health Commons $32,500 Glycemia Reduction Approaches in Effectiveness of Innovative Research Mentor Diabetes: A Comparative Effectiveness Interventions Among Underrepresented Kimberly Page Study Year 7 $672,584 Minority Faculty in the Southwest $701,440 National Institute on Drug Abuse New Mexico Clinical Trials Node: Clinical National Institute of Diabetes and Miners Colfax Medical Center Digestive and Kidney Diseases Medical Consultation and Care $152,342 Research and Practice to Address Substance Use in Diverse, Rural and Underserved Diabetes Prevention Program (DPPOS)- Phase 3 - Y26 $313,764 Miners Colfax Medical Center Populations $2,751,799 Medical Consultation and Care $34,122

National Institute on Drug Abuse Case Western Reserve University Epidemiology of Diabetes Intervention Miners Colfax Medical Center Acute Hepatitis C Infection in Young Medical Consultation and Care - Y3 $34,122 and Complications $126,549 Injectors $1,268,832 QTC Medical Group Upstate Affiliate Organization Case Western Reserve University Epidemiology of Diabetes Intervention and Second Medical Opinion Evaluations Patient-Centered Models of Hepatitis C FY19 $25,000 Care for People Who Inject Drugs - Complications and Hypoglycemia-Arrhythmia Study - Supplement $29,647 Continuation Y2 $429,986 Miners Colfax Medical Center An Innovative Approach to Increasing Access to Miners in the Mountain West $21,517

unm health sciences center 2019 / contracts and grants 37 Miners Colfax Medical Center Medical Consultation and Care $12,500

Elaine Thomas New Mexico Department of Health Sexually Transmitted Disease Clinical Services w/ BAA $40,512

Mark Unruh Anonymous Non-Profit Foundation Medical Directorship - Evergreen $1,181,620

Anonymous Non-Profit Foundation Medical Directorship and QA $1,181,620

University of Pittsburgh Technology-Assisted Stepped Collaborative Care Intervention to Improve Patient- Centered Outcomes in Hemodialysis Patients $217,743 Cara Therapeutics, Inc. Selectively Expand VRC01 Lineages From a University of Washington Consulting Agreement - Cara Fully Humanized Immunoglobulin Repertoire Treatment Options for Insomnia Therapeutics $6,400 - Continuation (Year 3) $80,457 for ESRD $123,330 Steven (Bruce) Williams Vojo Deretic Anonymous Non-Profit Foundation HRSA/HIV-AIDS Bureau National Institute of General Medical Medical Directorship and QA $67,900 Ryan White HIV/AIDS Program Part D Sciences Coordinated HIV Services and Access to Autophagy, Inflammation and Metabolism Anonymous Non-Profit Foundation Research for Women, Infants, Children, in Disease Center $2,224,034 Medical Directorship - Evergreen $67,900 and Youth $492,914 National Institutes of Health Anonymous Non-Profit Foundation HRSA/HIV-AIDS Bureau Autophagy Against Tuberculosis and Medical Directorship - Evergreen $67,900 Ryan White HIV/AIDS Program Part D HIV $744,529

Albuquerque Area Indian Health Service Coordinated HIV Services and Access to National Institute of Allergy and Infectious Nephrology and Rheumatology IHS Specialty Research for Women, Infants, Children, Diseases Services $67,595 and Youth $135,271 Pattern Recognition Receptors and Autophagy Emory University Molecular Genetics & in Mtb Control in AIDS $493,666 Advanced Care Planning for Dialysis Microbiology Michael Mandell Patients and Surrogates: An Effectiveness- National Institute of Allergy and Infectious Implementation Trial of SPIRIT in Judy Cannon Diseases ESRD $65,560 Tau Technologies Prevention of HIV-Induced T Cell Killing Interacting Swarms of Agents: From by Autophagy $224,160 University Of Pennsylvania Immunology to Social Media - Data Coordinating Center for Hemodialysis Continuation $215,456 Mary Ann Osley Pilot Studies Consortium (ACTION) $56,853 National Institute on Aging Bryce Chackerian Functional Analysis of Cellular St. Catherine Healthcare and National Institutes of Health Quescence $310,575 Rehabilitation Center A Nanoparticle-Based Vaccine Targeting Medical Director Services $41,472 PCSK9 $580,797 Michelle Ozbun

Janssen Pharmaceutical St. Catherine Healthcare and Henry M. Jackson Foundation Infectious Transmission of Human Rehabilitation Center Epitope-Based Vaccines for Neisseria Medical Director Services $41,472 Papillomavirus From Patient Gonorrhoeae $279,243 Samples $514,893

Lovelace Respiratory Research Institute National Institutes of Health National Cancer Institute Occupational and Environmental Health Opioid Vaccine Development Using Mechanisms of Infection by Oncogenic Clinical Services $25,000 Bacteriophage Virus-Like Particle HPVs $335,528 Immunogens - Admin Supplement $251,499 Lovelace Respiratory Research Institute American Cancer Society Occupational Environmental Health Clinical Massachusetts General Hospital MEK/ERK Signaling: An Achilles' Heel for Services $25,000 Innate-Like BCR Activity As a Template HPV-Induced Tumorigenesis $240,000 Honeywell Aerospace for Universal Vaccination Against Influenza Virus $154,019 National Institutes of Health Professional Occupational Medical Sex-Based Differences in Oral HPV Infections Services $6,658 Massachusetts General Hospital and Outcomes $227,250 CDRH3-Independent B Cell Stimulation to

38 unm health sciences center research annual report 2019 National Cancer Institute Surojit Paul Post-Translational Programming of the EGFR Signaling As the Nexus for HPV National Institute of Neurological Gluccocorticoid System in a Sexually Oncogene Regulation $40,167 Disorders and Stroke Dimorphic Manner $335,604 Role of Brain-Specific Tyrosine Phosphatase Jonathan Brigman Xuexian Yang STEP in Neuroprotection and Death - National Institute on Alcohol Abuse and National Institutes of Health FY20 $503,383 Leptin Promotes Allergic Asthma Through Alcoholism Unfolded Protein Responses $189,375 John Phillips Prenatal Alcohol Exposure and Corticostriatal Eunice Kennedy Shriver National Institute Control of Behavioral Flexibility $335,714 Neurology of Child Health and Human Development University of California, San Diego Building Research Capacity in Child Neurophysiological Biomarkers of Behavioral Christopher Calder Neurology: A U.S./Sri Lanka Research Dimensions $146,223 San Juan Regional Medical Center Collaborative - FY19 $177,186 Professional Services $25,000 Kevin Caldwell The Mind Research Network National Institute on Alcohol Abuse and Vertex Pharmaceuticals MRN Medical Director $50,373 Incorporated Alcoholism Protocol VX16-150-102: A Phase 2, Stefan Posse Sex-Dependent Effects of Prenatal Randomized, Double-Blind, Placebo- National Institutes of Health Alcohol Exposure on Developmental Controlled, Six-Week, Parallel-Design Study Concurrent High-Speed fMRI and MRSI Programming $335,774 of the Efficacy and Safety of VX-150 in (R21) $176,501 Nikolaos Mellios Treating Subjects With Pain Caused by Small The Mind Research Network National Institutes of Health Fiber Neuropathy $1,006 MDA Core-COBRE III - FY20 $14,464 Role of Psychiatric Disease-Associated

Corey Ford Circular RNAs in Neuronal Function and The Mind Research Network Actelion Clinical Research, Inc. Cognition $361,240 MDA Core-COBRE III $13,935 AC-058B302: Multicenter, Randomized, Johns Hopkins University Double-Blind, Parallel-Group, Add-On Michel Torbey Placental Mediated Mechanisms of Perinatal Superiority Study to Compare the Efficacy The Mind Research Network Brain Injury $4,827 and Safety of Ponesimod to Placebo in MRN Administrative Operations - Subjects With Active Relapsing Multiple FY20 $20,860 Erin Milligan Sclerosis Who Are Treated With Dimethyl National Institute on Alcohol Abuse and Fumerate (Tecfidera®) $267,374 Jennifer Vickers Alcoholism New Mexico Department of Health Prenatal Alcohol Exposure Potentiates PPD Development CMS Outreach Clinics - Neurology $21,100 Pain Via Lifelong Spinal-Immune Clinical Trial Agreement Phase 3 Changes $292,878 (Sub-Study) $203,093 Guangbin Xia University of Rochester Nora Perrone-Bizzozero Novartis Pharmaceuticals Corporation FOR-DMD: Double-Blind Randomized Trial to The Mind Research Network Protocol OMB157G2399: An Open-Label, Optimize Steroid Regimen in Duchenne MD Mining the Genome-Wide Scan: Genetic Single-Arm, Multi-Center Extension Study AWD00001200 $18,180 Profiles of Structural Loss in Schizophrenia - Evaluating Long-Term Safety, Tolerability and Non-Specific Supplement $3,210 Effectiveness of Ofatumumab in Subjects Yi Yang With Relapsing Multiple Sclerosis $180,901 electroCore, LLC Daniel Savage electroCore Supplement $5,650 National Center for Advancing Adamas Pharmaceuticals, Inc. Translational Sciences ADS-AMT-MS303: A Multicenter, Open- Atif Zafar Impact of SAR152954 on Prenatal Alcohol Label Safety and Efficacy Study of ADS-5102 University of California, San Francisco Exposure-Induced Neurobehavioral Deficits - Amantadine Extended Release Capsules in The Brain Vascular Malformation Continuation $301,164 Patients With Multiple Sclerosis and Walking Consortium: Predictors of Clinical Course - Impairment $45,667 Phase 3 Clinical Trial $170,672 Bill Shuttleworth National Institute of Neurological University of Southern California University of Chicago Disorders and Stroke Acculturation, Genetic Ancestry, and Trial Readiness in Cavernous Angiomas With Spreading Depolarizations and Neuronal Disability in Hispanic Americans With Multiple Symptomatic Hemorrhage - Year 2 $38,000 Vulnerability $326,885 Sclerosis Phase 4 - Continuation $39,722 GEPS Physician Group of New Mexico New Mexico State University University of Southern California Stroke Care w/BAA $15,000 New Mexico IDEeA Networks of Biomedical Acculturation, Genetic Ancestry, and Neurosciences Research Excellence $157,965 Disability in Hispanic Americans With Multiple Sclerosis Phase 4 Clinical Andrea Allan New Mexico State University Trial $39,154 National Institute of Environmental Health New Mexico IDEeA Networks of Sciences \Biomedical Research Excellence - Specific Tobias Kulik Prenatal Arsenic Exposure Alters Supplement $9,999 University of Cincinnati Transcriptional, Post-Transcriptional and Multi-Arm Optimization of Stroke Thrombolysis Stroke Trial $58,219

unm health sciences center 2019 / contracts and grants 39 Carlos Valenzuela Cibola General Hospital New Mexico Department of Health National Institute on Alcohol Abuse and Hospital Service Agreement Provide Risk-Appropriate Prenatal Medical Alcoholism (ACCESS) $125,000 Services to Medically Indigent Women in Alcohol and Developing Neuronal Circuits New Mexico With Obstetrical and/or Medical Holy Cross of Taos (MERIT AWARD) $378,750 Complications $54,960 Hospital Service Agreement National Institute on Alcohol Abuse and (ACCESS) $125,000 Albuquerque Area Indian Health Service Alcoholism OBGYN IHS Specialty Services $36,244 Alta Vista Regional Hospital Alcohol Research Training in Master Hospital Agreement Neurosciences $158,588 New Mexico Department of Health (ACCESS) $125,000 Certified Nurse Midwife Contractor Project Tou Yia Vue w/BAA $25,000 Union County General Hospital National Institute of Neurological Master Hospital Agreement Disorders and Stroke Anonymous Non-Profit Foundation (ACCESS) $125,000 Fellowship in Family Planning $979 Underlying Molecular Mechanisms of Gliogenesis and Gliomagenesis in Rehoboth McKinley Christian Health Care New Mexico Department of Health the CNS $240,594 Services Certified Nurse Midwife Contractor Project Master Hospital Agreement Jason Weick w/BAA - Specific Supplement $316 (ACCESS) $125,000 Clemson University Lisa Hofler RII Track-2 FEC: The Creation of Next- Los Alamos Medical Center New Mexico Department of Health Generation Tools for $232,758 Master Hospital Agreement Tubal Ligation Sterilization (Multi- (ACCESS) $125,000 Year) $202,560 Neurosurgery San Juan Regional Medical Center New Mexico Department of Health Andrew Carlson Master Hospital Agreement Family Planning and Vasectomy $72,228 Polyganics (ACCESS) $125,000 Professional Services Agreement $10,000 University of California, San Francisco Lovelace Health System Rex Jung SWS $6,000 Master Hospital Agreement Johnson O'Connor Research Foundation (ACCESS) $125,000 RAD The Neuroscience of Aptitude - Cost of Care $5,000 Continuation $66,825 Nor-Lea General Hospital Yuko Komesu Jeremy Lewis Master Hospital Agreement (ACCESS) $25,000 Research Triangle Institute InVivo Therapeutics Corporation Human Microbiome Study-ESTEEM Invivo-100-105: Invivo-100-105: Randomized, Obstetrics & Gynecology (PFDN Capitation) $310,000 Controlled, Single-Blind Study of Probable Benefit of the Neuro-Spinal Scaffold™ for Gillian Burkhardt Cook Myo Site Safety and Neurologic Recovery in Subjects Hopewell Funds Protocol 15-06: CELLEBRATE: An Adaptive, With Complete Thoracic AIS a Spinal Gynuity RAD $39,412 Two-Stage, Double-Blind, Stratified, Cord Injury As Compared to Standard Randomized, Controlled Trial Comparing of Care $94,130 Conrad Chao the Safety and Efficacy of AMDC-USR With New Mexico Department of Health Placebo in Female Subjects With Stress Edwin Nemoto High-Risk Prenatal Care $82,460 Urinary Incontinence $154,894 Kinesio Taping Association International Kinesio Taping in Medical Eve Espey Jamie Krashin Applications $53,900 New Mexico Department of Health Society of Family Planning Family Planning & STD Services Post-Fellowship Salary Support $113,152 Peter Shin Project $551,166 Eastern New Mexico Medical Center Society of Family Planning Master Hospital Agreement Anonymous Non-Profit Foundation Lacto-rod $15,000 (ACCESS) $125,000 Fellowship in Family Planning $401,729 Brenda Pereda Howard Yonas St. Vincent Hospital/Richard M. Angle Anonymous Non-Profit Foundation Presbyterian Healthcare Services Cancer Treatment Addressing Racism and Inequity in Family Professional Services/ Professional Services $307,409 Planning Care $232,582 Consultations $402,000 St. Vincent Hospital/Richard M. Angle Anonymous Non-Profit Foundation Miners Colfax Medical Center Cancer Treatment Addressing Racism and Inequity in Family Master Hospital Agreement Professional Services $300,000 Planning Care $29,997 (ACCESS) $125,000 Christus St. Vincent Regional Medical Memorial Medical Center Center Master Hospital Agreement Professional Services - Auto-Renew $235,391

(ACCESS) $125,000 First Choice Community Healthcare Professional Services $86,649

40 unm health sciences center research annual report 2019 Office of the Medical Investigator U.S. Department of Veterans Affairs ExplorAbilities, Inc. VA 2018 - 2019 Non-Forensic Autopsy Professional Services (Orthopaedics & Karen Cline Parhamovich Services $120 Rehabilitation) $33,696 Lovelace Health System FY20 Lovelace Health System - Autopsy Lori Proe Gehron Treme (Billing Through NSAR) $8,000 New Mexico Crime Victims Reparation Synthes, Inc. Commission Depuy Synthes AO Trauma $10,000 Lauren Decker OMI Grief Services 2019 $104,683 New Mexico Department of Health Johnson & Johnson FY19 OMI Mass Fatality Planning $49,849 National Center for Chronic Disease Synthes AO Prevention and Health Promotion Resident Education Support Tuition/Travel New Mexico Department of Health OMI UNM SUID SDY Application $59,800 Grant $5,475 FY19 New Mexico Violent Death Reporting System $5,275 Orthopaedics & Rehabilitation Stryker Orthopaedics & Rehabilitation OTA Fall Residents Comprehensive Fracture Hannah Kastenbaum Marybeth Barkocy Course $3,972 New Mexico Public Safety Department University of Oklahoma 2018 Paul Coverdell Forensic Science Special Education Research and Innovation to Daniel Wascher Improvement Award $78,320 Improve Services and Results $4,244 Arthrex, Inc. Arthrex Orthopaedic Sports $20,000 Sarah Lathrop Thomas Decoster New Mexico Department of Health Arthrex, Inc. Smith & Nephew, Inc Opioid Mortality Surveillance (Increase Arthrex Orthopaedic Trauma $5,000 2019-2020 Fellowship Support Funding Y3) $51,379 Program $20,000 Biomet, Inc. U.S. Consumer Product Safety Commission BIOMET 2019 AAOS Conference $1,500 Pathology MECAP Reports $1,260 Rick Gehlert Tione Buranda U.S. Consumer Product Safety Commission Bonesupport Sandia Biotech, Inc. MECAP Reports $882 Clinical Trial of CERAMENT As Part PSA Sandia Biotech, Inc. $4,000 of Surgical Repair of Open Diaphysial Kurt Nolte Tibial Fractures (FORTIFY) - Specific Douglas Clark New Mexico Department of Health Supplement $153,564 TriCore Reference Laboratories FY19 OMI Death Certificates & Toxicology Medical Directorship and Professional Panels for Potential Overdose Deaths $211,867 Beth Moody Jones Services $2,664,190 Langford Consulting, Inc. U.S. Department of Veterans Affairs Professional Services Agreement $37,764 Kendall Crookston VA 2018 - 2019 Non-Forensic Autopsy Vitalant Research Institute Services $30,143 Antony Kallur Transfusion Medicine Fellowship $99,973 NuVasive Inc New Mexico Department of Health Nuvasive, Inc $38,400 Karissa Culbreath FY19 NM Non-Pending Toxicology Specimen TriCore Reference Laboratories Support $26,638 Robert Schenck CRSA_Clinical Performance of the University of Pittsburgh Accelerate Phenotest™ BP Kit Using the U.S. Department of Justice Surgical Timing and Rehabilitation for Accelerate Pheno™ System for Determining FY19 Expert Witness Agreements $25,000 Multiple Ligament Knee Injuries: A Organism Identification, Semi-Quantitation, Multicenter Integrated Clinical Trial $10,815 and Antimicrobial Susceptibility Testing Lovelace Health System FY19 Lovelace Health System - Autopsy From Respiratory BAL and Mini-BAL (Billing Through NSAR) $8,000 Samples $6,500

TriCore Reference Laboratories Protocol: 120616rlm: BHI Broth With Ciprofloxacin and Macconkey Agar With Ciprofloxacin $1,498

TriCore Reference Laboratories Gamma Evaluation of Accelerate Sample Phenoprep™ Module, Accelerate Phenotest™ BP Kit, and Reference Method for BAL and Mini-BAL Specimens $1,300

Bruce Edwards University of Connecticut Developing a Screening Campaign for Immune Enhancers $151,500

unm health sciences center 2019 / contracts and grants 41 Mohammad Vasef TriCore Reference Laboratories Biocartis to UNM IRB Review Fees (Dr. Vasef) $3,200

Angela Wandinger-Ness National Institutes of Health Academic Science Education and Research Training - Continuation $809,129

National Cancer Institute The Role of Rac1 in Ovarian Cancer Metastasis and Niche Interaction $33,990

Stephen Young DNA Electronics Protocol 22-0001-01: Sample Acquisition Study to Evaluate the DNA Electronics Inc Pathogen Capture System and DNAe Group Holdings Genalysis System (LIDIA Bloodstream Infection Test) $18,993

Jennifer Gillette Lipid Rafts in Giardia by Super Resolution Pediatrics American Cancer Society Imaging $30,000 Shirley Abraham CD82 Regulates Acute Myeloid Leukemia Oregon Health & Science University Adhesion With the Bone Marrow $792,000 Samuel Reynolds TriCore Reference Laboratories Hemophilia Treatment Centers National Institutes of Health PSA: Clinical Performance of CINtec PLUS (SPRANS) $34,250

Functional Role of Tetraspanin CD82 in Cytology on the VENTANA Benchmark Oregon Health & Science University Hematopoietic Stem Cell Interaction - ULTRA Instrument for Identification of High- Regional Hemophilia Network-Mountain Continuation $378,750 Grade Cervical Disease When Used As States - Continuation $34,250 a Reflex Test in High-Risk HPV-Positive National Cancer Institute Women $42,105 American Thrombosis and Hemostasis The Impact of CD82 Expression on Acute Network Myeloid Leukemia Chemosensitivity and TriCore Reference Laboratories A Natural History Cohort Study of the Safety, Disease Relapse - Continuation $33,396 Multi-Center, Retrospective, Pivotal Study Effectiveness, and Practice of Treatment for to Evaluate the Accuracy and Precision of Diane Lidke People With Hemophilia (ATHN 7) $31,900 the Aperio Epathology System for Primary Genmab Diagnosis of Formalin-Fixed Paraffin- Novo Nordisk, Inc. Dissecting the Mechanisms of Action for Embedded Tissue Section: Professional Protocol No. NN7008-3553 Hexabody-Driven DR5-Induced Cell Services $22,500 A Multi-Center Non-Interventional Study Death $259,844 of Safety and Efficacy of Turoctocog Alfa TriCore Reference Laboratories (RFVIII) During Long-Term Treatment of National Institute of General Medical PSA TriCore/Roche $5,485 Sciences Severe and Moderately Severe Haemophilia a Imaging the Early Events in Membrane Larry Sklar (FVIII≤2%) $31,834

Receptor Signaling $1 National Institutes of Health Oregon Health & Science University A High-Throughput Chemical Screen to David Martin Community Counts $26,407 Identify Inhibitors of the Azole Transporter TriCore Reference Laboratories Cdr1p in Candida $273,077 Novo Nordisk, Inc. Multi-Center, Retrospective, Pivotal Study NN7415-4322: A Prospective, Multi-National, to Evaluate the Accuracy and Precision of University of Miami Non-Interventional Study in Haemophilia A the Aperio Epathology System for Primary Illuminating the Druggable Genome and B Patients With or Without Inhibitors Diagnosis of Formalin-Fixed Paraffin- Resource Dissemination and Outreach Treated According to Routine Clinical Embedded Tissue Sections: Professional Center $255,000 Treatment Practice $17,214 Services $22,500 Gilead Sciences American Thrombosis and Hemostasis Aaron Neumann Evaluation of Novel Probes - Network National Institutes of Health Continuation $198,006 ATHN Data Quality Counts: Nano and Microscale Molecular Boston Children's Hospital Round 10.1 $10,400 Machines for Innate Immune Sensing Compounds That Block a Novel Candida of Candida $358,138 Oregon Health & Science University Albicans Target $146,388 ATHENA1: Characterizing the Impact and University of Texas at El Paso Treatment of Reproductive Tract Bleeding on Elucidation of Structures and Functions of Gilead Sciences Evaluation of Novel Probes - Specific Women With Bleeding Disorders $4,000 Supplement $73,100

42 unm health sciences center research annual report 2019 Pacific Sickle Cell Regional Collaborative Pacific Sickle Cell Regional Collaborative $2,000

Tanya Baker-McCue New Mexico Division of Vocational Rehabilitation DVR School to Work $500,000 New Mexico Division of Vocational Rehabilitation DVR School to Work Project $500,000

New Mexico Division of Vocational Rehabilitation DVR Partners for Employment $410,000

New Mexico Division of Vocational Rehabilitation Loretta Cordova de Ortega Village Interventions and Venues for Activity DVR Partners for Employment $410,000 New Mexico Department of Health II - Continuation $405,091

Children's Medical Services Outreach Clinics New Mexico Developmental Disabilities Centers for Disease Control and Project - Specific Supplement $46,200 Planning Council Prevention DDPC Information Network $165,000 Ben Archer Prevention Research Center Core

Health Center, Inc. Continuation $328,909 New Mexico Developmental Disabilities Professional Services - Continuation $25,000 Planning Council New Mexico Department of Health DDPC Information Network $165,000 San Juan Regional Medical Center Teen Outreach Program $300,899

Echocardiograms - Continuation $25,000 New Mexico Developmental Disabilities Centers for Disease Control and Planning Council Northern Navajo Medical Center Prevention DDPC Health Access MOU $10,000 Provide On-Site Pediatric Genetic Clinic NOPREN - Early Childcare Settings Serving

Services for the Northern Navajo Medical Southwest American Indians and Hispanic New Mexico Developmental Disabilities Center - Shiprock $4,800 Populations $80,000 Planning Council DDPC Health Access MOU $10,000 Northern Navajo Medical Center New Mexico Department of Health Service Contact $4,800 Implementing Evidence-Based Sophie Bertrand Recommendations in Community New Mexico Children, Youth & Families Theresa Cruz Projects $30,939 Department New Mexico Human Services Department Home Visiting Training $1,461,411 SNAP-Ed Evaluation $167,366 New Mexico Resiliency Alliance Multivariate Resiliency Index Laura Caffey Thornburg Foundation Development $5,400 Health Resources and Services Increasing Home Visiting Referrals Through Administration Implementation, Dissemination and Walter Dehority New Mexico Pediatric Pulmonary Center - Evaluation $85,000 Medpace Inc. Continuation $298,875 MDA 2013-0039: A Phase 3, Multi-Center Presbyterian Healthcare Services Study to Evaluate the Efficacy and Safety New Mexico Department of Health REACH $72,000 of Mino-lok Therapy in Combination With Summer Asthma Institute Project $6,920 New Mexico Department of Health Systemic Antibiotics in the Treatment of Anthony Cahill Safe Sleep $21,100 Catheter-Related or Central Line-Associated HRSA/Maternal and Child Health Bureau Bloodstream Infection $32,000 New Mexico Department of Health New Mexico Perinatal and Infant Oral Zavante Therapeutics, Inc. Health Quality Improvement Project - Violence Prevention Project $10,500 ZTI-01-100: Single-Dose of ZTI-01 Continuation $249,918 McCune Charitable Foundation (Fosfomycin for Injection) in Pediatric American Association on Health & PRO HV - 2018 $10,000 Subjects (Less Than 12 Years of Age)

Disability Receiving Standard of Care Antibiotic Presbyterian Healthcare Services Therapy for Proven or Suspected Infection or Project Accessibility USA: Health Mobile Food Market $10,000 Promotion for Women With Disabilities - for Peri-Operative Prophylaxis $32,000 Continuation $34,600 National Dance Institute - New Mexico Sara Del Campo de Gonzalez NDI-NM Eval $3,500 Glenda Canaca Harvard Graduate School of Education New Mexico Human Services Department Sally Davis Health’s Early Roots & Origins: Field Social Marketing $389,653 Centers for Disease Control and Testing Measures of Stress System Prevention Activation in Children in Pediatric Primary Care Settings $36,503

unm health sciences center 2019 / contracts and grants 43 Darrell Dinwiddie New Mexico Public Education Department New Mexico Department of Health University of Washington Improving Student Health and Academic Long-Acting Reversible Contraception Admin Supplement for MLVP $75,750 Achievement Through Nutrition, Physical Training and Stocking Project - Specific Activity and the Management of Chronic Supplement $87,125 Elif Dokmeci Conditions in Schools $20,000 AbbVie Santa Fe Community Foundation M16-049: An Open-Label, Multiple-Dose John Kuttesch LARC Mentoring Program $60,000 Study to Evaluate the Pharmacokinetics, St. Baldrick's Foundation Safety and Tolerability of Upadacitinib Improving Access to Clinical Research Santa Fe Community Foundation in Pediatric Subjects With Severe Atopic Trials $60,000 New Mexico Early Childhood Funders Group Dermatitis $175,703 - LARC Mentoring Program - Non-Specific Children's Hospital of Philadelphia Supplement $52,000 Sandra Heimerl Per Case Reimbursement Clinical Rider- HRSA/Maternal and Child Health Bureau Industry Work Order, PH II, PH+ALL - Santa Fe Community Foundation New Mexico LEND: Leadership Education in Continuation $54,300 New Mexico Early Childhood Funders Group Neurodevelopmental Disabilities $661,653 - LARC Mentoring Program - Non-Specific Children's Hospital of Philadelphia Supplement $20,000 HRSA/Maternal and Child Health Bureau Phase 3 Clinical Trial - Industry $12,800 New Mexico LEND: Leadership Education in Marcia Moriarta Neurodevelopmental Disabilities $339,361 Jean Lowe New Mexico Children, Youth & Families University of California, San Francisco Department HRSA/Maternal and Child Health Bureau High-Dose Erythropoietin for Asphyxia ACA-CYFD Nurse Family Partnership New Mexico LEND: Leadership Education in and Enciphalopathy CCC Project - PAT $3,035,053 Neurodevelopmental Disabilities $293,801 Continuation $23,196 New Mexico Department of Health New Mexico Developmental Disabilities University of California, San Francisco DOH Autism Programs $2,774,040 Planning Council High-Dose Erythropoietin for Asphyxia and New Mexico LEND Legislative Advocacy Enciphalopathy CCC Project - Specific New Mexico Human Services Workshop $2,500 Supplement $10,462 Department Improving Quality (75/25 & 50/50 Andrew Hsi University of Washington Medicaid Match) Supporting Child New Mexico Department of Health Preterm Epo Neuroprotection Trial CCC: Development Through Evidence-Based DDSD FIT (FOCUS) $66,000 Capitation $10,100 Practices $2,000,000

Lauren Jantzie University of Washington New Mexico Human Services Army Medical Research Acquisition Preterm Epo Neuroprotection Department Activity Trial CCC $5,000 Improving Quality (75/25 & 50/50 Mechanisms and Non-Surgical Treatment Medicaid Match) Supporting Child of Acquired Symptomatic University of Washington Development Through Evidence- Hydrocephalus $1,126,208 Preterm Epo Neuroprotection Based Practices $2,000,000 Trial CCC $5,000 Patricia Keane New Mexico Human Services Department Peggy MacLean CHILE Plus $305,063 Erikson Institute Erikson Institute FBN ECHFS FY19 $8,700 Alberta Kong Janssen Research & Development, LLC Ksenia Matlawska-Wasowska 28431754DIA3018: A Randomized, National Institutes of Health Multicenter, Double-Blind, Parallel-Group, The Roles of SOCS5 in T-ALL Migration and Placebo-Controlled Study to Investigate Tissue Infiltration $343,258 the Efficacy and Safety of Canagliflozin in Jane McGrath Children and Adolescents (≥10 to <18 Years) New Mexico Department of Health With Type 2 Diabetes Mellitus $93,044 Long-Acting Reversible Contraception Training Brindle Foundation and Stocking Project - Continuation $250,000 Optimizing Care for Neonatal Opioid Withdrawal Syndrome in Rural New New Mexico Department of Health Mexico $25,000 Long-Acting Reversible Contraception Training and Stocking Project $162,875 Klein Buendel Web App Santa Fe Community Foundation Technology for Boys and Parents: Improving New Mexico Early Childhood Funders Group - HPV Vaccine Uptake $23,882 LARC Mentoring Program $150,000

44 unm health sciences center research annual report 2019 New Mexico Department of Health Martha Muller Carlsbad Municipal Schools Early Childhood Evaluation Program SGF/ Merck, Sharp & Dohme, Inc. Carlsbad Consultations $14,191 Part B/part C $1,082,000 MK7655A-021-0358: A Clinical Study to Evaluate the Safety, Tolerability, Efficacy and Silver Consolidated Schools New Mexico Children, Youth & Families Pharmacokinetics of MK-7655A in Pediatric Silver Consolidated Schools Department Participants From Birth to Less Than 18 Years Consultations $13,958 CDD Preschool Development Grant $748,500 of Age With Confirmed or Suspected Gram- Albuquerque Public Schools Negative Bacterial Infection $291,258 Falling Colors Corporation APS Consultations $11,033 Early Childhood Infrastructure Development Cystic Fibrosis Foundation Belen Consolidated Schools (FY19) $598,000 Cystic Fibrosis Center of New Mexico - Belen Consultations $11,000 CF Registry $63,345 Administration for Community Living Belen Consolidated Schools University Center for Excellence in Sylvia Negrete Belen Public Schools Consultations $10,765 Developmental Disabilities $547,000 Anonymous Sponsor

Healthy Lifestyles Programming $50,000 Silver Consolidated Schools New Mexico Department of Health Silver Consolidated Schools DDSD Partners for Employment $546,235 Dawn Novak Consultations $9,729 New Mexico Department of Health New Mexico Department of Health Developmental Care Continuity Program - Silver Consolidated Schools Early Childhood Network $534,900 Fee for Service - Continuation $118,000 RBT Supervision $9,518

Falling Colors Corporation New Mexico Department of Health Bernalillo Public Schools Infant Mental Health Community of Developmental Care Continuity Program - Bernalillo Consultations $6,250 Practice $400,000 Continuation $61,390 Estancia Municipal Schools Irving Harris Foundation New Mexico Department of Health Estancia Municipal Schools Harris Center for Excellence in Infant and Developmental Care Continuity Program - Fee Consultations $5,775 Early Childhood Mental Health $360,000 for Service - Specific Supplement $57,620 Moriarty-Edgewood School District New Mexico Public Education Department Robin Ohls Moriarty Edgewood Consultations $5,664 Early Childhood Evaluation Program SGF/ RTI International PartB/PartC - PED $150,000 Silver Consolidated Schools NICHD Cooperative Multicenter Neonatal Silver Consolidated Schools FY2019 $4,976 New Mexico Department of Health Research Network: TOP 5 and NRN $50,000 DDSD Statewide Training Database $111,607 Lucille Papile Pat Osbourn Stanford University New Mexico Department of Health New Mexico Public Education Department Webinar Implementation for the Science Project SET $106,191 PED Pre-K Consultation $1,674,717 of Enhancing Resilience NICUs Study - Qualis Health New Mexico Public Education Department Continuation $1,810 In-Home Assessments for Medically Fragile FOCUS Preschool Special Education $583,983 Linda Penaloza Waiver w/BAA - Continuation $102,125 New Mexico Public Education Department New Mexico Department of Health New Mexico Department of Health PED Contract - SET, DB, PSN $429,950 YRRS - Continuation $169,201 DDSD Informed Choice $100,000 New Mexico Public Education Department New Mexico Department of Health New Mexico Department of Health PED Pre-K Consultation $226,825 YRRS - Specific Supplement $95,000

Medically Fragile Case Management $86,000 Region IX Education Cooperative Albuquerque Public Schools New Mexico Department of Health Region IX Education Cooperative - APS 1807 $77,000 New Mexico SAFE Program $83,437 Autism $212,453 New Mexico Public Education Department Falling Colors Corporation U.S. Department of Education PED Evaluation $36,500 Parent Infant Psychotherapy $63,000 Project for New Mexico Children Who Are Deaf-Blind $107,917 New Mexico Public Education Department New Mexico Department of Health PED Evaluation $36,500 DDSD FIT - Specific Supplement $61,730 New Mexico Developmental Disabilities Planning Council New Mexico Department of Health Brindle Foundation Partners in Policymaking/EC Project $67,000 Sexual Violence Prevention Meeting $3,323 Clinical Consultation for Rural Hengameh Raissy Providers $25,000 Rio Rancho Public Schools Rio Rancho Consultations $55,690 inVentiv Clinical, LLC New Mexico Department of Health AV003: Phase 3 Study Evaluating the DDSD Partners for Employment - Rio Rancho Public Schools Efficacy and Safety of PT027 Compared to Supplement $6,600 Rio Rancho Consultations $55,690 PT007 Administered As Needed in Response

to Symptoms in Symptomatic Adults and Albuquerque Public Schools Children 4 Years of Age or Older With APS Consultations - Specific Supplement Asthma (MANDALA) $77,587 FY19 $20,567

unm health sciences center 2019 / contracts and grants 45 New Mexico Department of Health Piloting the Effectiveness of the Low-Literacy Pictorial Asthma Action Plan Project $52,750

Norma Ventura American Academy of Pediatrics Flu2text: A Multi-Site Study Assessing an Intervention for Second Dose of Influenza Vaccine $1,000

Jennifer Vickers New Mexico Department of Health CORE Developmental Disabilities Waiver Outside Review Project $1,501,100 New Mexico Department of Health Continuum of Care $858,800 New Mexico Department of Health Mortality Review $52,750

Kristi Watterberg Vertex Pharmaceuticals, Inc. HBSA Eunice Kennedy Shriver National Institute VX17-445-105: A Phase 3, Open-Label New Mexico School-Based Health Center of Child Health and Human Development Study Evaluating the Long-Term Safety and Evaluation $39,838 NICHD Cooperative Multicenter Neonatal Efficacy of VX445 Combination Therapy Network $273,421 in Subjects With Cystic Fibrosis Who Are New Mexico Department of Health Homozygous or Heterozygous for the DOH Clinical Support for Provision of Family RTI International F508del Mutation $49,033 Planning, Pregnancy Testing and Sexually NIH/NICHD Neonatal Capitation (NRN)- Transmitted Infection $36,280 Continuation $273,421 Celtaxsys Clinical Trial Agreement - Phase 2 - Pacific Institute for Research & Evaluation Carla Sue Wilhite Continuation $42,424 Implementing School Nursing Strategies to New Mexico State University Reduce LGBTI Adolescent Suicide $20,000 New Mexico Agrability - Assistive Technology Vertex Pharmaceuticals, Inc. Program for Farmers With Disabilities $12,141 Phase 3 Clinical Trial $41,000 Leslie Strickler New Mexico Crime Victims Reparation Craig Wong Duke University Commission The Children's Mercy Hospital Pharmacokinetics and Safety of Anesthetics Para Los Ninos CVRC $352,600 CKiD IV $27,767 and Analgesics in Children $37,875 New Mexico Crime Victims Reparation Presbyterian Healthcare Services Vertex Pharmaceuticals, Inc. Commission Pediatric Nephrology On-Call VX17-445-102: A Phase 3, Randomized, CVRC - SAS State Grant $352,600 Services $25,000 Double-Blind, Controlled Study Evaluating the Efficacy and Safety of VX-445 Combination New Mexico Crime Victims Reparation Presbyterian Healthcare Services Therapy in Subjects With Cystic Fibrosis Who Commission Pediatric Nephrology On-Call Victims of Crime Act - ACCESS $72,064 Services $25,000 Are Heterozygous for the F508del Mutation and a Minimal Function Mutation $31,744 U.S. Department of Justice Presbyterian Healthcare Services Expert Witness Contract - Farnham $11,203 Pediatric Nephrology On-Call AstraZeneca Pharmaceuticals, LP Protocol D3250c00045: Multicenter, Services $25,000 U.S. Department of Justice Randomized, Double-Blind, Par of US DOJ - U.S. v. Duran $9,900 Nationwide Children's Hospital Benralizuallel Group, Placebo-Controlled, Cure Glomerulonephropathy $15,500 Phase3b Study to Evaluate the Safety and U.S. Department of Justice Efficacymab 30mg Sc in Patients With Expert Witness Contract - Soseeah $6,673 Elizabeth Yakes Jimenez Severe Asthma Uncontrolled on Standard of Academy of Nutrition and Dietetics Care Treatment $20,110 Nicole Urrea Director of the Dietetics Practice-Based Duke University Research Network $318,981 University of Utah BMS01 PK & Safety of Commonly Used Multicenter Validation of Predictive Sputum Drugs in Lactating Women & Breastfed Academy of Nutrition and Dietetics Biomarkers in CF $2,000 Infants $15,150 Director of the Dietetics Practice-Based Research Network $98,000 Mary Ramos Monique Vallabhan Conrad N. Hilton Foundation Health Resources and Services SBIRT in School-Based Health Centers in Administration New Mexico $750,000 Telehealth Network Grant $299,999

46 unm health sciences center research annual report 2019 Psychiatry & Behavioral Sciences The Mind Research Network COBRE III $37,873 Christopher Abbott National Institutes of Health Annette Crisanti ECT Current Amplitude and Medial Temporal Bernalillo County Lobe Engagement - Continuation $506,411 Collaborative Interdisciplinary Evaluation and Community-Based Treatment $160,000 The Mind Research Network Data-Driven Approaches to Identify Department of Health Biomarkers From Multimodal Imaging Big Medication-Assisted Treatment in Emergency Department $140,000 Data $17,957 American Psychological Association Deborah Altschul APA Fellowship Yr 2 - Alonso San Felipe Pueblo Marsden $49,844 San Felipe Native AWARE (Advancing Wellness and Resiliency in Lucas Dunklee Education) $1,250,000 Massachusetts General Hospital

Augmentation Versus Switch: Comparative San Felipe Pueblo Effectiveness Research Trial for Antidepressant San Felipe Zero Suicide $525,000 Incomplete and Non-Responders With Taos Pueblo Division of Health and Treatment-Resistant Depression $271,035 Falling Colors Corporation Community Services Martha "Molly" Faulkner Healthy Transitions Expansion Grant Taos Pueblo Tiwa Babies Program - FY19- National Institute on Drug Abuse FY21 $140,000 (HTEP) FY19 $16,667 NIMH Outreach Partnership Program San Felipe Pueblo FY20 $7,500 New Mexico Children, Youth & Families KEYWAH II - Katishtya Embraces Youth, Brian Isakson Department Wellness, and Hope $119,515 CYFD Community of Care Expansion $8,800 New Mexico Children, Youth & Families Falling Colors Corporation Department Julie Salvador Multi-Systemic Therapy Data Reporting Healthy Transitions Expansion Grant Falling Colors Corporation (HTEP) $807,500 Initiative (MST Data) - FY19 $31,400 New Mexico State Opioid Response -

Substance Abuse and Mental Health Continuation SFY20 $669,723 Falling Colors Corporation Services Administration ASURE-TI - Adolescent Substance Use Falling Colors Corporation ACTION II - Addressing Childhood Trauma Reduction Effort - Treatment New Mexico State Opioid Through Intervention, Outreach, and Implementation $10,000 Response $500,654 Networking - Continuation FY20 $399,717 U.S. Indian Health Service Agency for Healthcare Research and Substance Abuse and Mental Health IHS Mental Health First Aid $9,952 Quality Services Administration Innovative Model for Increasing MAT Access Caroline Bonham Addressing Childhood Trauma Through (AHRQ MAT) - FY19 Continuation $389,610 U.S. Indian Health Service Intervention, Outreach, and IHS Tele-Behavioral Health, Training & Networking II $333,333 Falling Colors Corporation Consultation $799,909 New Mexico State Opioid Response - Falling Colors Corporation Amendment 1 $236,880 New Mexico Human Services Department Bridges to Wellness Evaluation (Promoting New Mexico Consortium for Behavioral Integration of Physical and Behavioral Falling Colors Corporation Health, Training & Research Health Care) - Continuation FY20 $184,220 New Mexico State Opioid Response - Development II $210,000 Supplement $163,928 Falling Colors Corporation U.S. Indian Health Service Bridges to Wellness Evaluation (Promoting Mauricio Tohen IHS Tele-Behavioral Health, Training & Integration of Physical and Behavioral Bernalillo County Consultation $74,900 Health Care) $75,000 Psychiatric Services $89,000

Albuquerque Area Indian Health Service First Choice Community Healthcare Ann Waldorf Albuquerque Area IHS Clinical Training First Choice Community Healthcare $73,402 Center for Substance Abuse Treatment and Education $24,750 UNM - Provider's Clinical Support Substance Abuse and Mental Health System $150,000 Juan Bustillo Services Administration The Mind Research Network COPE Primary Care Integration (ICOPE-PC) - Falling Colors Corporation COBRE III $48,689 Specific Supplement $25,000 Assertive Community Treatment - FY20 $135,790 The Mind Research Network Falling Colors Corporation COBRE III $46,603 Bridges to Wellness Evaluation (Promoting Falling Colors Corporation Integration of Physical and Behavioral Assertive Community Treatment $101,657 Health Care) - Specific Supplement $21,055

unm health sciences center 2019 / contracts and grants 47 Radiology HEALTH SCIENCES LIBRARY Albuquerque Public Schools & INFORMATICS CENTER Behavioral Health Assessment & Gary Mlady Treatment for Students $10,000 U.S. Department of Veterans Affairs Provide Radiological and Nuclear Medicine Patricia Bradley Robert Perry Diagnostics and Therapy Services for University of North Texas Health Sciences New Mexico Department of Health NMVAHSC FY20 $3,141,736 Center Mass Fatality Planning $58,822 Growing STEM: A New Mexico New Mexico Department of Health Journey $10,000 New Mexico Department of Health BCC Early Detection Program - Provide Services for Hospital Specific Supplement $33,394 Stuart Nelson Preparedness $49,954 iNational Library of Medicine New Mexico Department of Health Feasibility of a Therapeutic Intent Suzanne Popejoy BCC Early Detection Program $126,891 Ontology $170,438 New Mexico Children, Youth & Families Department Surgery OFFICE FOR DIVERSITY, UNM Hospitals Young Children Health Center $618,500 Arup Das EQUITY & INCLUSION Genentech, Inc. City of Albuquerque YOSEMITE GR40349 $1,178,160 Valerie Romero-Leggott Scope of Services-Gang Prevention $239,378 Science Education Solutions National Eye Institute Teen Science Cafe Network Small City of Albuquerque Novel Biomarkers & Genetics of Diabetic Grant $3,000 Early Intervention for Children Retinopathy $512,760 Services $141,503 UNM HOSPITAL New Mexico Commission for the Blind Jody Stonehocker Commission for the Blind - Emergency Eye Wendy Hine New Mexico Department of Health Care Program $125,000 New Mexico Department of Health Provide Prenatal and Postpartum Clinical, New Mexico Commission for the Blind Provide Case Manager and Junior Health Education $180,000 Emergency Eye Care Program $125,000 Accountant Services $85,000 Jennifer Vosburgh Bridget Fahy-Chandon Rodney McNease Rico Aviation Stanford University Bernalillo County Helipad Use Agreement $10,000

A Multi-Center Randomized Controlled Trial Provide Housing to Homeless in Criminal Justice System $498,726 UNM MEDICAL GROUP, INC. of Perioperative Palliative Care Surrounding Cancer Surgery for Patients and Their Family Bernalillo County Members $181,544 David Rakel Provide Housing to Homeless in Criminal Bernalillo County Juvenile Detention Center Justice System $138,411 Professional Services $136,973 Stanford University A Multi-Center Randomized Controlled Trial of Perioperative Palliative Care Surrounding Cancer Surgery for Patients and Their Family Members $181,544

Rohini McKee American Society of Colon & Rectal Surgeons Brandeis Leadership Health Policy Scholarship $2,800

Jasmeet Paul ACell ACell Educational Grant $6,000

John Russell Presbyterian Medical Services On-Call Surgical Services $34,560

Presbyterian Medical Services On-Call Surgical Services $13,560

Joaquin Tosi Genentech, Inc. Protocol GR40549 PORTAL $3,072,798

Genentech, Inc. Protocol GR40548 ARCHWAY $2,173,971

48 unm health sciences center research annual report 2019 How to Donate to UNM Health Sciences Center Research Join Us on Our Journey of Discovery

Our research programs are focused on critical health problems affecting New Mexicans and bridging the gap to more rapidly deliver discoveries to the clinical setting. Often, the benefits of our innovations and discoveries are recognized and shared beyond our state borders to institutions in other states and in countries around the world.

Your contributions will help us meet new challenges and seek solutions to help people lead longer and healthier lives. Donations are accepted through the UNM Foundation, the university-based nonprofit that can accommodate almost any giving interest. Options include support of health research in general, work in a particular disease category, one of our signature programs for scholarships or facilities, or a legacy gift customized to fit the wishes of you as an individual, your family or your company.

For more information on how you can contribute to the UNM Health Sciences Center’s discoveries and innovations of the future, contact Bill Uher, Vice President of Development, UNM Foundation, at [email protected] or 505-277-4078.

About the Foundation The University’s Board of Regents established the UNM Foundation in 1979 as a nonprofit corporation. Ten years later, the Regents delegated the responsibility of overseeing University of New Mexico assets and investments to the UNM Foundation Investment Committee. These assets total more than $400 million today.

In 2008, the Foundation became a stand-alone organization with expanded fiduciary duties to include fiscal, human resources and treasury functions. All private gifts to the Health Sciences Center are received through the UNM Foundation, which manages contributions to all university programs. The Foundation’s funding model ensures that 100 percent of gifts are directed to the donor’s designated purpose. OFFICE OF RESEARCH 1 University of New Mexico MSC08-4560, Fitz Hall B-61 Albuquerque NM 87131-0001

UNM HEALTH SCIENCES CENTER Discovery Research Annual Report 2019

UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER TURNING RESEARCH INTO CURES

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