JANUARY 2006 ASCB NEWSLETTER 3 ASCB Council Report

ASCB JANUARY 2006 NEWSLETTER VOLUME 29, NUMBER 1 Beckerle ASCB Holds 45th Annual Meeting Becomes President in San Francisco Page 2 Council Approves 2007 Budget, Reviews Programs, Meets with CSR Director, Bad Budget Welcomes New Staff Amidst healthy reserves and strong ﬁnancial performance, the for NIH ASCB Council met last month to review programs and publi- Page 31 cations, consider new initiatives, and continue to usher publications and meetings into the 21st century. Zena Werb of the University of California, San Call for Francisco, who completed Science, Networking: and Sessions: New Nominations her term as President at year- science presented at end, presided over the two- poster sessions (above), Page 44 day Council meeting. Mary students socialize Beckerle, of the University at the Reception for Undergraduate Poster MBC InCytes of Utah Huntsman Cancer Presenters, and (below) Page 50 Institute, became President Bruce Alberts Award January 1st, and Bruce winner Samuel Silverstein Alberts became President- (left) and 2006 President-Elect elect. Larry Goldstein com- Bruce Alberts. Inside pleted his term as Secretary, and Jean Schwarzbauer assumed the role this month. In addition, other Council members present included: Treasurer Gary President’s Column 2 Ward; Past-President Harvey Lodish; Councilors Kerry Bloom, ASCB Council Report 4 Tony Bretscher, Juan Bonifacino, David Burgess, Peter Devreotes, Linda Hicke, Kathryn Howell, Caroline Kane, Erin Keane ASCB Committee Reports 8 O’Shea, and Janet Shaw; and Councilor-elect Sandra Masur.

Annual Meeting Highlights 18 See Council Report, page 4 Public Policy Briefing 31 Dear Labby 34 Join the Congressional ASCB Profile 35 WICB Column 40 Liaison Committee Concerned about government funding for cell biology research? Not sure how to participate in ASCB ad- Member Gifts 41 vocacy on research funding and science policy issues? The Congressional Liaison Committee (CLC) of the Members in the News 42 Joint Steering Committee provides you with the tools you need to influence decisionmakers. The CLC is AAAS Fellows 43 operated by the ASCB, the Genetics Society of America, the Society for Neuroscience, and Science Service. As a CLC member you will receive alerts about important pending legislation or other federal actions so Call for Nominations 44 that you can make your feelings known to your elected representatives. In addition, the CLC will provide New Members 46 you with talking points, background information, and how-to tips to strengthen your message. InCytes from MBC 50 It has never been more important for scientists to communicate with their elected officials. Continued advocacy for the NIH, the NSF, and other funding agencies is essential (see NIH story, page 31). There is Grants & Opportunities 52 no cost to join the CLC. Simply complete the form found at www.jscpp.org/clc. For further information, Classified 52 contact JSC National Coordinator Lynn Marquis, at [email protected]. ■ Calendar 56 The American Society for Cell Biology PRESIDENT’S Column 8120 Woodmont Avenue, Suite 750 Bethesda, MD 20814-2762 Tel: (301) 347-9300 Fax: (301) 347-9310 The ASCB Needs YOU! [email protected]; www.ascb.org The American Society for Cell Biology has been Developing and Promoting Best Joan R. Goldberg my primary scientifi c organization since I was Practices a graduate student with Keith Porter, one of Executive Director Along with the constant focus on scientifi c ex- its founders. I attended my fi rst ASCB meet- cellence and exchange, there have been many Offi cers ing in 1978 when I was a second year gradu- changes. Over the years, the Society has assumed Mary Beckerle ate student. I remember driving my pale yellow President a leadership role in several areas: public affairs Bruce Alberts President-Elect 1971 VW beetle, with sunroof, from Boulder, and advocacy, education, scientifi c publishing, Zena Werb Past-President Colorado, to San Antonio with a fellow student, and issues for women and minorities in science. Gary Ward Treasurer Susan Spath. We got up early, stayed up very Jean Schwarzbauer Secretary The ASCB has consistently late, and slept on the fl oor in a looked to the future, developing room already occupied by four Council and promoting best practices in students from Dan Branton’s Kerry Bloom all its areas of interest and infl u- lab, friends of Susan’s from her Juan Bonifacino ence while providing forums to days as a lab tech at Harvard. David Burgess discuss professional challenges If memory serves me, Velia John Condeelis and opportunities. Peter Devreotes Fowler, now at Scripps, was in The past successes of the Linda Hicke one of the beds; we have been many Society initiatives have Caroline Kane friends ever since. Sandra Masur relied on members’ energy I was awestruck by the Barbara Meyer and commitment. Likewise, science at the meeting— Anne Ridley the future impact of our both the quality and the Erin O'Shea existing programs and new Daphne Preuss magnitude. I had never seen so initiatives will depend on many posters in my life. I was your involvement. Many of ASCB Newsletter working on cell motility, and I Mary Beckerle you have expressed an interest is published twelve times per was fascinated to see what Gary in becoming involved in the year by The American Society Borisy and Tom Pollard actually for Cell Biology. Society’s activities. Some have looked like. I witnessed their wondered aloud how they might participate. animated debate in a minisymposium session. Joan R. Goldberg Editor One focus of the coming year will be to Having read many of their papers in my classes, John L. Saville Production Manager develop strategies to engage more members Nancy Moulding Production Assistant it was incredible to see these in contributing to our Kevin Wilson Public Policy Briefi ng scientifi c heroes in action. shared goals. I view this Ed Newman Advertising Manager It was also tremendously John Fleischman Science Writer as a central challenge and exciting to meet so many “… the Society has opportunity for the Society. people with common assumed a leadership The challenge has arisen interests and to experience Deadlines for submission of role in … public simply because of our being part of a vibrant articles and advertising remarkable growth. When international community of affairs and advocacy, materials: I attended my fi rst annual cell biologists. education, scientifi c meeting, the ASCB had a Issue Deadline Nearly 30 years later, total membership of 3,600. March February 1 the core focus of the ASCB publishing, and April March 1 This year, we have over on promoting scientifi c May April 1 issues for women and 11,000 members. While the exchange in cell biology scope of ASCB activities remains unchanged. The minorities in science.” and the number of working ASCB Newsletter Society continues to organize committees has increased, ISSN 1060-8982 an exceptional annual Volume 29, Number 1 a smaller percentage of meeting. The meeting brings the membership January 2006 our members currently enjoy the experience of together, highlights recent scientifi c advances, participating actively in the work of the Society. © 2006 and provides an opportunity for discussion The American Society for Cell Biology We have a tremendous opportunity to avail and debate. The program for the 46th annual ourselves of the energy and experience of our Postmaster: Send change of address to meeting—to be held next December in San ASCB Newsletter membership. There is much important work American Society for Cell Biology. Diego—is currently being developed by Tony 8120 Woodmont Avenue, Suite 750 to be done, and the Society truly needs the Bethesda, MD 20814-2762 Bretscher and his committee.

2 ASCB NEWSLETTER JANUARY 2006 participation of our members to maximize the with minority members (2005). At the San Diego impact of ASCB activities. meeting next December, the leadership will host a conversation with international cell biologists, who Promoting Involvement in represent nearly 23% of the Society’s membership. Defined Goals This will enable us to learn how we can best support the needs of our international community I have asked each committee chair to identi- of cell biologists. fy activities that would benefit from additional member engagement. Beginning next month, Maintaining Our Responsibilities these will be highlighted in the Newsletter with to the Community information on how you can volunteer to par- There may be a tendency at a time like this, ticipate. We are not envisioning increasing the when funding is tight and the business aspects size of our regular committees, which are al- of the scientific enterprise may feel all-consum- ready quite large. Rather ing, for scientists to assume we hope to identify new a stance that is more com- ways for members to con- petitive than collaborative, tribute to ASCB activities. more insular than expansive. Opportunities for participa- “Member engagement I do not mean to minimize tion will vary in time com- is key to the vitality the impact of the current mitment and in focus— of our already robust funding climate. Indeed, perhaps reviewing meeting both of my grants are up abstracts, leading a discus- scientific society. for renewal this year. So I sion group at an annual or Participation is know the meaning of stress, summer meeting, electron- and I know it is much worse ic mentoring, participating empowering and will for junior scientists trying in local advocacy--we will make a difference ….” to establish their programs. aim to have something for Nevertheless, even in these everyone! We also antici- trying times, we must not pate that future committee lose sight of the joy of the appointees will be solicited scientific enterprise and our responsibilities as from the group of actively engaged members. scientists to our broader community. Member engagement is key to the vitality The energy and commitment of our of our already robust scientific society. members have: (1) had a significant impact Participation is empowering and will make a on framing the debate on the teaching of difference in our ability to achieve our aims. evolution in U.S. public schools, (2) increased I believe it is also critical to the future of the the appreciation of our elected officials and Society. Our future depends on a loyal and the public for the value of biomedical research, active membership that participates in defining (3) provided mentoring and guidance for cell the focused goals of the ASCB and, therefore, by biology trainees, (4) developed wonderful definition, embraces those goals. periodicals to highlight advances in cell biology Former ASCB President Suzanne Pfeffer took and education, (5) provided tutorials to enhance the lead in establishing member forums at the professional development, and (6) created a Annual Meeting. Members representing selected community of cell biologists who share a passion interest groups meet with the elected leadership of for our field. the Society to brainstorm about issues of particular With your involvement, we have tremendous concern and develop concrete strategies to address potential to lead in the future. As Margaret them. These sessions have been held on Saturday Mead said, “A small group of thoughtful people afternoon, before the opening of the meeting. could change the world. Indeed, it’s the only Meeting invitees were selected by lottery. The thing that ever has.” I look forward to working meeting in 2003 with student members of the with you in the coming year and beyond. ■ ASCB led to separate listings of student events in the Annual Meeting Program and a “students” web Comments are welcome and should be sent to site (the Community Forum). Similar round-table [email protected]. discussions were held with post-docs (2004) and

JANUARY 2006 ASCB NEWSLETTER 3 ASCB Council Report

Council Report, continued from page 1 Ennist, Director of Publications Mark Leader, and Joint Steering Committee National The ASCB Council thanked Interim Coordinator Lynn Marquis, to their first Executive Director David Driggers and other meeting. staff. Councilors also welcomed new ASCB Executive Director Joan Goldberg, along with Image and Video Library Curator David New Initiatives Approved Council considered and acted upon a variety of proposals: ■ A call for an NIH Consensus Development Conference to counter the growing problem of cross contamination and misidentification of cultured cells: Endorsed. ■ Free registration for high school teachers at the Annual Meeting: Approved. ■ Options for the Society’s 50th Anniversary Celebration: A task force will be established. ■ Outreach to ASCB international members: To be re-invigorated. ■ A review of past and planned ASCB 2005 ASCB Council: (back row, left to right) Janet Shaw, Linda Hicke, Kathryn Howell, Peter summer meetings: Their financial impact Devreotes, Juan Bonifacino, Anthony Bretscher, Erin O’Shea, Kerry Bloom. (Front row, left to right) and educational value were considered; a Jean Schwarzbauer, then Secretary Lawrence Goldstein, President-Elect Bruce Alberts, Executive task force was established to investigate Director Joan Goldberg, then President Zena Werb, then President-Elect Mary Beckerle, Past- President Harvey Lodish, and Treasurer Gary Ward. technology (e.g., webcasting). Council also expressed interest in cosponsoring such meetings with international groups. ■ Discontinuing the print version of the ASCB Directory of Members: With online, member-only accessible, continuously updated information available, Council agreed that the print version was outdated. Saved funds can be better applied to travel grants, etc. See Council Report, page 6

4 ASCB NEWSLETTER JANUARY 2006 � � � � ��

��

�� e x p r e s s r e p r e s s d e t e c t

Open Biosystems - “shRNA” Ad ASCB Newsletter - w: 8.25” x h: 10.875” (trimmed) ASCB Council Report

Council Report, continued from page 4 1, 2005, start, Scarpa has focused on improv- 45th ASCB ing the management, receipt, referral, and co- Annual Meeting Finances and Membership Presented ordination of CSR peer review. He respond- Ward presented an overview of ASCB’s finances ed to Werb’s ASCB Newsletter charge (August Statistics and the draft FY 2007 budget, which was 2005) that “the judging of grants has become approved. a charade,” by emphasizing the importance of Members ...... 3,132 CSR peer review. Nonmembers ...... 773 ASCB membership was over 11,000 by Students ...... 1,147 year’s end, noted Goldstein. Retention of Scarpa reported that NIH received 80,000 Nonmember students ...... 656 regular members is good. A 2006 membership grant applications in 2005; this number Guests of Exhibitors ...... 965 survey will highlight member needs and has climbed significantly since 2001 and satisfaction. nearly doubled since 1998. He shared data Total Scientific demonstrating that 2/3 of the grants submitted Participants ...... 6,673 result from researchers writing more grants Exhibitors ...... 2,395 CSR Director Antonio Scarpa Described Changes than previously: The average number per Press ...... 48 To address innovations in NIH grant review, researcher grew to 1.2 by 2002 and 1.4 by 2005. In addition, Scarpa noted: Total Registration ...... 9,116 and to discuss ideas for further improvement, Center for Scientific Review (CSR) Director ■ More RO1 applications request salary Antonio Scarpa joined Council. Since his July support. ■ More faculty is supported 100% by grants.

Addressing Review Cycle, Reviewer ASCB Exhibit Hall Shortage, and Peer Review 524 Booths, 360 Companies, 2,395 Exhibitors To help fulﬁll CSR’s mission, Scarpa is working with staff to: ■ Shorten the review cycle ■ Improve the assessment of innovative, high- risk/high-reward research ■ Increase recruitment and retention of high quality reviewers Council recommended shorter grant applications, questioned the value of appendices, and agreed on the need to shorten review cycles and attract more senior reviewers.

ASCB Program Expansion Discussed Rounding out the Council Meeting were: ■ Presentations on the Image and Video Library, scheduled for launch this spring ■ Concerns raised regarding NIH and NSF funding and the need for member involvement in advocacy efforts ■ Updates on ASCB publications and committees ■ Discussions on expanding ASCB international outreach, the successful ﬁrst ever Cell Film Contest, and media outreach year-round ■ Brainstorming about: ❏ Educational strategies for diverse audiences regarding evolution ❏ Educational approaches in recognition of the ASCB’s 50th anniversary in 2010 ❏ Strategies for increasing member involvement (see page 2) ■

6 ASCB NEWSLETTER JANUARY 2006

ASCB COMMITTEE Reports

A major theme of the meeting was the effort Keynote Symposium/Opening Night Reception to make the journal more inclusive of other areas of biology: ■ The name of the journal has changed to CBE–Life Sciences Education (CBE–LSE). The URL will be www.lifescied.org. ■ Board members are being recruited with expertise in other life science disciplines, including plant biology and microbiology. ■ Several cross-disciplinary special issues are Attendees at the Keynote hear Linda Buck, Fred Hutchinson Cancer Research Center/ planned: Neuroscience (Summer 2006), ASCB President Zena Werb introduces new HHMI (left), and Claire Fraser, The Institute Developmental Biology (2007). Executive Director Joan Goldberg and Interim for Genomic Research (right), speak on the ■ Links will be created to tables of contents of Executive Director David Driggers. topic of Big Science, Little Science. other life science education journals. Wood announced that Elgin, Campbell, and Gary Reiness will serve as Senior Editors, advising the Editor-in-Chief and overseeing features. The group discussed topics for upcoming articles and special issues. It reafﬁrmed its ambition that the journal will generate a culture of research among teachers. The Board approved changes to the Instructions for Authors that address sharing of propagative biological Former ASCB Executive Director Elizabeth Marincola was recognized at the Keynote materials, instructional materials, and data and Symposium. (Left to right:) 1995 President Institutional Review Board approval of research Ursula Goodenough, Marincola, and 2004 involving human subjects. President Suzanne Pfeffer. The group discussed the ﬁnancial status of the journal. Members of the Board expect that the journal will continue to be sustained by grants and by support from biological societies. The Board believes that introducing publication fees would reduce submissions and that requiring paid subscriptions would limit readership.

Education Committee Hosts Annual Meeting Events, Focuses on 2006 The Education Committee hosted a variety of well-attended events at the 2005 ASCB Annual Meeting, including the Education Workshop, the 5th Annual K–12 Science Education Partnership Lunch, three Education Initiative CBE Changes Name, Expands Forums, the Bruce Alberts Award presentation, Scope a reception for undergraduate students, and the The number of registered users has more than Education/Minorities Affairs Committee Booth. doubled for the former Cell Biology Education For more information, visit www.ascb.org/com- since early 2005, Editor-in-Chief William Wood mittees/edcom/index.html. announced at the 2005 Editorial Board meeting. Members of the committee discussed topics He thanked former Coeditors-in-Chief Sarah and possible speakers for next year’s ASCB Elgin and Malcolm Campbell for building the Annual Meeting in San Diego. In addition, journal and making it a success. committee members agreed to reorganize the

8 ASCB NEWSLETTER JANUARY 2006 ASCB COMMITTEE Reports

undergraduate reception to include a poster display and link it to the preceding student EB Wilson Medal Presentation program. The Education Committee also plans Joan Steitz of Yale University to help publicize the ASCB Image and Video School of Medicine/HHMI Library, currently under development, at various receives the ASCB’s highest honor from then ASCB President biology conferences during the year. Zena Werb. Image and Video Library Report The Image and Video Library, a comprehensive, high quality internet collection covering the field of cell biology is governed by two new boards. A Scientific Advisory Board (SAB), chaired by Kathryn Howell, is composed of ASCB member scientists. The SAB works closely with Curator David Ennist to develop the scientific content of the peer-reviewed site. The External Advisory Board (EAB), chaired by Harvey Lodish, is comprised of both academic scientists and industry leaders. The EAB advises Steitz spoke about SnRNPs: Cellular and Viral Regulators of Gene Expression. the ASCB on business issues, including the development of business, marketing and fundrais- movies. The collection will be built by topics, ing plans. and contributions will be reviewed for possible The SAB has been hard at work gathering inclusion in the Library. All ASCB members will images that illustrate the contributions of the have the opportunity to contribute. Much work founders and early members of the ASCB. This remains to be done, including the construction of will form the groundwork for the expansion of on-line submission and review modules. ASCB the collection with more recent micrographs and expects to launch the website late this spring.

JANUARY 2006 ASCB NEWSLETTER 9 ASCB COMMITTEE Reports

MAC Committee The ASCB Social Activities at the San Francisco Museum of Modern Art Annual Meeting Over 700 meeting participants enjoyed the exhibits at the San Francisco Museum of Modern Art during the ASCB Chaired by Lydia Villa- Social. Komaroff, the ASCB Minorities Affairs Committee (MAC) met on December 12, 2005. In attendance were MAC members Renato Aguilera, David Burgess, Cherie Butts, Tony DePass, Sandra Murray, Thoru Pederson, Laura Robles, and Peter Satir. Invited guests included MAC Linkage Fellow Latanya Hammonds-Odie and 2005 MAC Postdoctoral Travel Awardee Veronica Lopez. Also attending were MAC Director Irelene Ricks and ASCB Executive Director Joan Goldberg. New 2006 members are: MariaElena Zavala (California State University, Northridge); and Eva McGhee (University of California, San Francisco). MAC priority issues included ensuring MAC continues support for faculty and student programs, including course support at the Marine Biological Laboratory; research collaborations of Visiting Professors and host faculty; and Linkage Fellows program participants. The MAC also proposed the design of a MAC Minority Speaker Visitors to the ASCB booth in San Francisco Referral Service for a variety of purposes, last month were treated to a preview of the including resources for academic institutions, website. The presentation featured an image private organizations, and the ASCB. MAC of the ﬁrst electron micrograph of a eukaryotic members also discussed issues of research, Annual Meeting cell, published by Keith Porter, Albert Claude tenure, teaching, and mentoring support. Lost & Found and Ernest Fullam in 1945. Lee Peachey, one The MAC was pleased by the success of There are a few unclaimed of Keith Porter’s graduate students, generously the annual MAC Mentoring Symposium items from the Annual loaned an original print so that a scan of this on December 10, 2005, in which over 150 Meeting such as a pair famous image could be made. The annotation of participants came to hear keynote speakers of glasses, gloves, a items in the collection will be extensive and will sweater, shirt, notes, keys, Bruce Alberts and George Langford. include a title, authors, description of the image etc. If you think you have The MAC was also encouraged by the with historical signiﬁcance (if any), materials and misplaced items from the enthusiastic participation of ASCB Council Annual Meeting, please methods, and a link to the original publication, if in a MAC-Council brown bag lunch about contact Trina Armstrong available. Readers should look for announcements underrepresented scientists in biomedical at (301) 347-9300 or via on the ASCB home page and in an upcoming [email protected]. issue of the Newsletter. See Committee Reports, page 12

10 ASCB NEWSLETTER JANUARY 2006 Custom Solutions for Your Research Recombinant Protein + Polyclonal Antibodies

New!

Custom Recombinant Protein+ Polyclonal Antibodies Select your gene of interest... Primm will provide

� Gene cloning � Protein fusion expression and puriﬁ cation � Rabbit immunization

1,950 Custom Antibodies $ PrimmBiotech, Inc. Box 425695 Kendall Square Cambridge, MA 02142 USA phone 800 893 4388 fax 617 325 2703 www.primmbiotech.com [email protected] ASCB COMMITTEE Reports

Committee Reports, continued from page 10 Press Room Nominating Committee research. Suggestions made by Chair Announced participants included providing more Elizabeth dynamic and interactive information Blackburn has for students on the ASCB MAC agreed to serve website; more information on the as the Chair Just Garcia Hill website/database for of the ASCB minority scientists; public and private Nominating grant writing workshops for minority Committee for faculty and postdocs at the ASCB 2006. Annual Meeting; and consideration Elizabeth Blackburn Blackburn is of alternative career pathways beyond ASCB Science Writer John Fleischman conducts daily at the University academia. [Note: There is an existing press briefings at the ASCB Annual Meeting. of California, San Francisco. She NSF workshop offered each Annual served as Society President in Meeting that describes available discussants of these and other science topics. 1997-98 and received the 2004 funding opportunities and tips on Rounding out a full MAC program in San ASCB Public Policy Award for her writing a successful grant proposal.] Francisco was E.E. Just Lecturer Maggie steadfast commitment to science- Other successful MAC activities Werner-Washburne on “The Quiescent State based policy while serving on the in San Francisco included 52 MAC of Yeast.” The Lecture was followed by the first President’s Bioethics Council. travel awardee poster presentations annual MAC Junior Faculty Workshop. The Nominating Committee will on December 10, 2005. Cash recruit candidates to run for ASCB prizes sponsored by St. Jude Schmid, Board Chart Course Council terms beginning in 2007, and Children’s Research Hospital were for a candidate to serve as President awarded to four graduate students. for MBC in 2008. Committee members will be Undergraduate, postdoctoral, and The 2005 meeting of the Molecular Biology of named later in 2006. ■ faculty cash awards were provided by the Cell (MBC) Editorial Board was very well at- an anonymous donor. tended. Editor-in-Chief Sandra L. Schmid re- Roundtable discussions later that marked that this was one of several signs that day involved science writing, science the Associate Editors are committed to the jour- ethics, pharmacia and universities. Guest nal. At the meeting, Schmid and the Associate speakers from Roche, Merck, The University Editors discussed recent enhancements to the re- of Arizona, and Science magazine were active view process and how the journal may increase its impact on the field. Schmid noted changes in the Board: ■ Randy Schekman resigned as Editor but will ASCB Business Meeting continue to serve as an Associate Editor. ■ Joan Brugge agreed to become an Editor, joining Richard Hynes, Tom Pollard, and Mark Solomon. ■ Eight Associate Editors are stepping down. Schmid thanked Schekman and the departing Associate Editors for their dedicated service to MBC. In recruiting new Associate Editors, Schmid said she tried to balance the expertise of the Associate Editors with the types of manuscripts received. The distribution of 2006 ASCB President Mary Beckerle papers among the Associate Editors has become and presiding President Zena Werb. much more even since last year’s Board changes. Another change is that the newly organized Board of Reviewing Editors (BRE) is now in place. The BRE will set the tone for constructive Above right: ASCB Treasurer peer review, maintain editorial consistency, Gary Ward updates members on Society investments. Right: and provide a broad range of expertise. Each Susan Gerbi listens to a query member of the BRE has agreed to review from Samuel Silverstein.

12 ASCB NEWSLETTER JANUARY 2006 ASCB COMMITTEE Reports

one or two papers per month for MBC; most advance knowledge or peer-reviewed papers will be reviewed by at provide new concepts or E.E. Just Lecture least one BRE member. Schmid has prepared approaches that extend guidelines for reviewers that emphasize the need understanding. for scholarly, constructive, and clear reviews. ■ She highlights outstanding Journal Production Manager Rachel Altemus papers in InCytes from demonstrated how to assign reviewers in the MBC, which appears in the journal’s online review system. ASCB Newsletter monthly Schmid presented data on the review process (see page 50) and in the and complimented the Associate Editors for print edition of the journal. ■ having reduced the time taken for every step in Any paper nominated 2005 ASCB the process. Overall, the time from submission by the Associate Editors President to first decision has dropped to about 19 days. for InCytes will also be a Zena Werb ASCB Director of Publications Mark Leader candidate for MBC ’s Paper presents the E.E. reported: of the Year award. Just Award ■ MBC received 1,112 new submissions There was a consensus to Margaret between November 2004 and October 2005, that the Essays section should Werner- a 9.1% increase over the previous year. be maintained for topics not Washburne of the ■ The journal continued to increase in size, to covered in typical review University of New Mexico. Werner-Washburne spoke 5,901 pages for the 2005 volume. journals and should be broadly about The Quiescent State in Yeast. ■ The average time from receipt to print defined to allow for flexibility. publication was 75.9 days in the period from December 2004 to November 2005. Public Information Committee ■ Authors’ final papers are typically posted online within a week of acceptance. Tackles Evolution, Press Schmid stated: Outreach ■ To avoid the journal becoming even larger In its regular meeting, the Public Information given increasing submissions, it will be Committee (PIC) discussed the new joint com- necessary to decrease the acceptance rate. mittee task force on “Creationism/ID/Evolution” ■ The journal’s most important criterion for mandated by Council. The task force will draw acceptance is that a paper should significantly on members from the PIC, and the Education and the Public Policy Committees. PIC members agreed that a three-legged response was probably Arshad Desai the best approach. They suggested various proj- Desai Named LAC ASCB Public Policy Award ects for the joint group, ranging from a stronger Presented “Evolution” section on the ASCB website to or- Chair ganizing “Practice of Science” workshops on how ASCB President Mary to talk about Evolution in your local communi- Beckerle announced the ty. Council has also asked the task force for rec- appointment of Arshad ommendations on how the ASCB can mark the Desai of Ludwig Institute Charles Darwin bicentennial in 2009. PIC mem- for Cancer Research as ber Tom Egelhoff volunteered to join PIC Chair Chair of the Society’s Local Rex Chisholm on the Evolution task force. Arrangements Committee. The committee also evaluated “Cell Biology Committee members will 2005,” the latest edition of the PIC’s press book be named this winter. for the Annual Meeting. Faced with increasing The 2006 Local competition from other scientific meetings Arrangements Committee and more restrictive embargo policies by “big” will organize events for the science journals, PIC asked for a new allocation ASCB Annual Meeting in to promote press coverage of the ASCB meeting. San Diego this December, Accepting the ASCB Public Policy Award for Sen. Arlen Specter (PA-R), Science Advisor for the U.S. Chisholm reported that Council had approved including the ASCB Senate Committee on Appropriations Sudip Parikh PIC’s $10,000 request. He would be soliciting Social, the High School urged Annual Meeting attendees to educate their proposals from public relations professionals to and Student Programs, representatives about science and ensure their present at the spring PIC meeting in Bethesda, and the ASCB-Invitrogen voices are heard. MD, in April 2006. Molecular Probes Run. ■

JANUARY 2006 ASCB NEWSLETTER 13 ASCB COMMITTEE Reports

Public Policy Education in Schools, On the Hill Bruce Alberts Award Committee Focuses The Committee discussed ongoing efforts Alberts Award to include the teaching of creationism and recipient Samuel on Funding Intelligent Design in science education curricu- Silverstein Funding for biomedical re- la. Goldstein reported that the ASCB Council of Columbia search was a major top- University College wants to have a set of events at the 2006 of Physicians & ic for the ASCB Public Annual Meeting centered on evolution. Along Surgeons and Policy Committee at its full with recommending a symposium speaker, the 2005 ASCB day meeting in December President Public Policy Committee will work with other Zena Werb 2005. In attendance were Society Committees to develop outreach events Mary Beckerle, David to take place at the 2006 meeting. Burgess, Committee Chair The ASCB continues to work closely Larry Goldstein, Ursula with the Joint Steering Committee for Goodenough, Dan Kiehart, Public Policy (JSC) and the Congressional Bob Palazzo, Tom Pollard, Biomedical Research Caucus. The Caucus has Randy Schekman, Maxine a membership of over 100 Representatives Singer and Zena Werb. Also and ten Senators. During 2005, the Caucus present were ASCB staff conducted 12 briefings on a wide range of Joan Goldberg and Kevin scientific topics including Parkinson’s Disease, Wilson and Joint Steering organ transplantation and nanotechnology. Silverstein spoke on Research Experiences for Committee for Public Policy The 12 briefings were attended by over 600 Science Teachers: Benefits for Students and the staff Peter Kyros and Lynn people, including Members of Congress and Economy. Marquis. Congressional staff. At the time the Changes in JSC staff forced a smaller Committee met, the U.S. number of Capitol Hill Days than normal. Congress had not yet approved the 2007 The JSC’s Congressional Liaison Committee ASCB budget for the National Institutes of Health (CLC) Capitol Hill Day program was only (NIH). Both the House of Representatives and able to conduct three of the five scheduled Hill 2006 the Senate had passed their own versions of Days. Despite the reduction, CLC members the Departments of Labor, Health & Human Summer Services and Education Appropriations bill, See Committee Reports, page 16 Meetings which contains funding for the NIH. The Senate bill included $29.323 billion for NIH, $1.049 billion or 3.7% more than last year’s Stem Cell Niches budget. The House bill allotted $28.515 billion Practice of Science Boston University for NIH, $241 billion or 0.5% more than the Boston, MA Maxine Singer, President previous budget. The first Conference Report Emerita of the Carnegie July 15-18 of House and Senate conferees included a Institution (left); Keith Yamamoto, University of budget of $28.526 billion for the NIH which is Deadlines California, San Francisco $252 million or 0.9% above the 2005 budget. (below left); and Allan Abstract: May 12 However, in an unusual move, the Conference Spradling, the Carnegie Registration: May 31 Institution of Washington/ Report was rejected by the full House of HHMI discussed How Long Representatives. The Cell Biology Should It Take to Train a Members of the Committee expressed Cell Biologist? of HIV-1 and Other Retroviruses concern that members of the biomedical Emory University research community were not actively engaged Atlanta, GA in public policy advocacy. Many reasons for the July 20-23 lack of interest were discussed. Public Policy Committee staff will focus on developing new Deadlines methods of advocacy to engage researchers Abstract: May 19 better. They will also reach out to other Registration: June 7 communities affected by reductions in NIH funding to engage them in the fight to increase www.ascb.org funding.

14 ASCB NEWSLETTER JANUARY 2006

ASCB COMMITTEE Reports

Committee Reports, continued from page 14 Keith R. Porter Women in Cell Biology conducted 95 Congressional meetings. 2005 Lecture Committee was the second year of a CLC travel award The Women in Cell Biology Committee met program funded by a grant from the Open on December 10 and discussed its programs, in- Society Institute. The awards have been cluding the workshop on conﬂict resolution, the particularly helpful in bringing constituents annual Career Lunch, the Evening Program, and to Washington, DC to meet with Members of selection and presentation of the WICB Junior Congress with whom JSC members had not and Senior Awards. Topics for the popular previously met. monthly ASCB Newsletter WICB Column were discussed, and potential authors identiﬁed. ■

Randy Schekman of the University of California, Berkeley/HHMI, delivers ASCB/Invitrogen-Molecular Probes Run the Porter Lecture on Morphogenesis of a Transport Vesicle.

All this effort, just to get a free t-shirt! Overall Winner of the Men’s 10K Runners Colleen Ball Women in Cell 10K: Christoph Burckhardt and Brad Nolen race toward Biology Awards from the University of Zurich. the ﬁnish line.

Greg Lucier from Invitrogen with Lucier with Men’s Overall 5K Taking a well-deserved rest after completing the Overall Women’s 10K winner Winner Michael Freeley of the race...and cheering on the rest of the runners Marjan Huizing of the National Trinity Centre Health Sciences, about to cross the ﬁnish line. Human Genome Research St. James Hospital in Dublin. Institute/NIH.

ASCB-Invitrogen- Molecular Probes Run Results

10K Overall Winners Top: WICB Chair Ursula Goodenough of Washington Christoph Burckhardt—33:28 University (right) presents the Marjan Huizing—41:27 2005 Junior Award to Rebecca Heald of the University of 5K Overall Winners California, Berkeley. Bottom: Michael Freeley—16:13 Elizabeth Blackburn of the Mission Accomplished! Overall Winner of the Women’s University of California, San 5K Jennifer Gillette from the Jennifer Gillette—25:07 Francisco (left), receives the WICB National Institute of Child Health Senior Award from Goodenough. & Human Development/NIH.

16 ASCB NEWSLETTER JANUARY 2006

ANNUAL MEETING Highlights

Lights! Camera! Cells! setting up an RSS feed and downloading the “Celldance 2005” Premieres in “Celldance 2005 Winners’ Reel” are at www. ascb.org. The winning entries of “Celldance San Francisco 2005” will also be submitted to the new ASCB Hollywood didn’t blink but the world pre- Image and Video Library. miere of “Celldance 2005,” the ASCB’s first annual cell biology film contest, at the Annual Meeting drew an excited crowd College Student Program and Council’s backing for a se- Addresses Pathogenesis Celldance Contest Winners quel. Organized by the Public Recent scares about a potentially looming avi- Information Committee (PIC), an flu pandemic thrust the field of pathogene- the contest’s $500 first prize sis back into the limelight. Or was it ever out of went to Daniela Cimini of the it? HIV, SARS, and dwindling flu vaccines have University of North Carolina at appeared in and out of the media. They are hot Chapel Hill for her short film, topics studied by some of the foremost research- “Meeting In The Middle Before ers in the world. By scrutinizing these microor- Parting.” ganisms, along with the many others that colo- Ron Vale of the University nize a variety of hosts, researchers continue to of California, San Francisco, diminish the mystery behind the cell biology of (Left to right:) ASCB Science Writer John Fleischman took the $300 second prize the host and its invaders. But can we ever tri- and Public Information Committee Chair Rex Chisholm present awards to Celldance winners Ron for his animation, “A Moving umph over them all? “Even if we conquer all of Vale of the University of California, San Francisco; Kinesin Motor Protein.” Rosalind the pathogens that we know, there will always and Rosalind Silverman-Gavrila of the University of Silverman-Gavrila of the Toronto. Kip Sluder (right) chaired the “Celldance” be something new coming down the pike,” stat- Public Information Subcommittee. University of Toronto won the ed Dan Portnoy of the University of California, $200 third prize for “In Perfect Berkeley. Synchrony.” The judges awarded Portnoy, along with Joe DeRisi of the honorable mentions to Alexey Khodjakov of the University of California, San Francisco, and Julie Wadsworth Center in Albany for “Dance of the Theriot of Stanford University, participated in a Chromosomes” and to Susan Janicki and David panel discussion entitled “Emerging Pathogens Spector of the Cold Spring Harbor Laboratory and Biodefense.” The forum was held during on Long Island for “DNA –> RNA –> Protein.” the college student program. Speakers discussed “Celldance 2006 is already in the works,” how they became involved in their current said PIC Chair Rex Chisholm. “Cell biology research endeavors. They also revealed interesting is an intensely visual science. These films will facts about the field of microbial pathogenesis. be useful in biology classrooms, but the PIC is Theriot recalled how, as a graduate student, after always looking for ways to open the eyes of the reading a paper by Portnoy’s lab, she became Renew Your world to life on the cellular level. This is just the beginning.” Chisholm praised PIC See Highlights, page 20 Membership member Kip Sluder for getting the “Celldance” contest off the Student Program for 2006 ground. From left to right: To continue enjoy- “Celldance 2005” was open to Joseph DeRisi, ing ASCB membership all ASCB members and attracted University of California, 29 entries from the U.S. and San Francisco; Julie benefits, including the Theriot of Stanford ASCB Newsletter, go to Canada. Judges were drawn from University; and Daniel www.ascb.org/ascbsec/ the PIC and the ASCB’s general DuesRenewal/dues06. membership. To overcome the cfm. daunting logistics of collecting, distributing and judging Portnoy, University entries from ASCB’s worldwide of California, Forgotten Your ID membership, “Celldance” was Berkeley, spoke Number? about Emerging conducted through an RSS or Pathogens and Contact the ASCB at “really simple syndication” feed, Biodefense. (301) 347-9300 or using free software developed for [email protected]. video podcasting. Instructions for

18 ASCB NEWSLETTER JANUARY 2006 2051106A Luca Biocam BioPh.qxd 26/1/06 11:00 am Page 1

Now pioneering EMCCD technology is within everyone’s reach.

LOW LIGHT IMAGING

Andor Luca is the latest imaging innovation from Andor, the leaders in EMCCD technology. Finally a cost- effective option making EMCCD available to every laboratory, for every application. Operate "gain off" for conventional CCD operation under brighter conditions, or turn on the EM gain when the photons become scarce! Features include:

- Single photon sensitivity. - Detection of extremely weak signals with optimal S/N and high resolution. - Rapid Frame Rate. - USB 2.0 interface. - Multiple camera support. Don’t hang around, net yours today! $8,850* • widefield fluorescence microscopy To find out more visit www.andor.com • living and fixed cells or www.emccd.com • single molecule detection • fluorescent proteins inc. GFP • FISH • immunofluorescence • comet assay

*Domestic US price quoted. www.andor.com ANNUAL MEETING Highlights

Highlights, continued from page 18 to ASCB Annual Meeting attendees at the annual Congress 101 and Congressional Leadership excited about the way the stomach churning Caucus (CLC) meetings. This message was also Listeria monocytogenes bacteria hijacks the echoed by Sudip Parikh, Science Advisor to the host’s machinery to invade and spread. DeRisi U.S. Senate Appropriations Committee, when later discussed he accepted the ASCB Public Service Award on the importance behalf of Senator Arlen Specter. Congress 101 of assays to detect Congress 101 was hosted by Larry Goldstein, ASCB Public Policy Committee Chair viruses of unknown ASCB Public Policy Committee Chair, and Larry Goldstein (at podium) and below etiology. He also was attended by over 100 people. The panel with fellow panelists JSC Education Liai- son Peter Kyros and WICB Chair Ursula explained how his also included the JSC Congressional Education Goodenough discussed the role that lab uses microarray Liaison Peter Kyros and Committee member scientists can play in influencing policy technology to and WICB Chair Ursula Goodenough. The in Washington, DC. identify mysterious presentation and audience discussion focused microbes and on why researchers should become involved in learn more about public policy advocacy and the valuable role elusive organisms they can play in influencing and shaping public like Plasmodium policy in Washington, DC. falciparum. The Joint Steering Committee for Public After each Policy’s (JSC) Congressional Liaison Committee researcher (CLC) reception also drew about 100 people spoke, the floor for an informal discussion on the best ways was opened to to approach your Member of Congress. Tom attendee questions. Pollard, who heads the CLC, hosted the panel Approximately discussion. The panel included Omar Quintero 150–200 college students from various who discussed his own experience in meeting his universities attended, and there was no shortage member of Congress through the JSC’s Capitol of inquiries for the panelists. One student from Hill Days. California State University (CSU), Monterey Bay, See Highlights, page 22 asked whether bioterrorism was really the threat portrayed by the media. Other students, from schools like CSU, Stanislaus and the University of Exhibitor Showcases California, Berkeley, inquired about the state of BD Biosciences presented several showcases current research funding, the correlation between highlighting its new imaging technologies. the rise in the human population and that of new viruses, and how chronic antibiotic use affects the way disease spreads in current society.

Congress 101/CLC Meeting The U.S. scientiﬁc community is facing challenging times due to cuts at the National Institutes of Health (NIH) that directly affect, among other budget priorities at NIH, new grants, grant size, and grant duration. Future NIH budgets look equally bleak. Scientists across the U.S. need to be actively involved to change the direction of current funding levels by meeting their Members of Congress, making a call to their ofﬁces, and/or writing a letter to their Senator. This was the message repeated

20 ASCB NEWSLETTER JANUARY 2006

ANNUAL MEETING Highlights

students, brings together students and professors Education Workshop for intensive seminars and bonding. It is held at Diane Ebert-May of Michigan State Lake Itasca, the headwaters of the Mississippi University conducted a lively and well- attended Education Workshop: Pathways River, during the summer. to Scientific Teaching. Charles Evans, Georgetown University, spoke about an outreach program to promote biomedical health careers among youth in three rural communities: Lakota Ogala Sioux American Indians from the Pine Ridge Reservation in South Dakota; African American and Cajun participants from Napoleonville, Louisiana; and Mexican-American students from a farm migrant worker community in Florida. The students travel to Washington, DC, and spend three weeks on the Georgetown Ebert-May discussed how undergraduates learn and how University campus. They attend lectures and assessment improves student field trips, experience laboratory exercises and learning to a rapt audience at the cultural activities, and participate in science Education Workshop. and nonscience classes. All of these activities expose the high school students to a myriad of biomedical science-based careers. Highlights, continued from page 20 Finally, Anna Ballew, Stanford University, described a lab course for university sophomores Peter Kyros, Lynn Marquis, the National that is designed to engage students in yeast Coordinator for the JSC, and Kevin Wilson, the genetics through the study of chemicals that may Public Policy Director for the ASCB, were also affect human health. The course allows students to on the panel. design their own projects; conduct independent, All panel members urged researchers to original research in the lab using sophisticated become involved in public policy advocacy equipment; collect data; and present their findings and stressed the many simple and non-time- in a final report and poster presentation. consuming things they can do such as calling or writing your Senator or Member of Congress. For information on how to be an effective High School Program Discusses voice for science, please contact Kevin Wilson Stem Cells at [email protected] or Lynn Teams around the world are working on ap- Marquis at [email protected]. proaches to stimulate stem cells to replace dead K–12 Science Education cells in diseases like Parkinson’s or diabetes. But Partnership Lunch Education Initiative many American researchers have sought posi- Barbara Nagle, SEPUP See Highlights, page 24 Director, Lawrence Hall Forums of Science (left), leads The three Education Initiative a discussion at the K- Forums sponsored by the 12 Lunch, Introducing Education Committee at the High School Cell Biology to K–12 Students: Getting Kids Annual Meeting attracted stand- Program Hooked on Microscopy. ing-room-only audiences. The forums, which were chosen from among many excellent education poster submissions, described topics of great interest and impact. Allan Spradling of the Robin Wright, University of Carnegie Institution Minnesota, described her school’s of Washington/HHMI program called “The Nature speaks about Bringing Basic Science to the of Life.” This highly successful, Study of Stem Cells. mandatory freshman orientation course for biological science

22 ASCB NEWSLETTER JANUARY 2006 ANNUAL�� MEETING Highlights �� Program Co-Chairs: George M. Carman, Rutgers University Laurie S. Kaguni, Michigan State University History Comes Alive...Register Now!

�� Mass Spectrometry and Proteomics �� Al Burlingame, UCSF and Juliette Bell, Fayetteville State Univ. �� Sue Weintraub, UTHSC, San Antonio Macromolecular Structure Issues in Breast Cancer Among Surface Plasmon Resonance and Dynamics Minority Populations and Proteomics Andrej Sali, UCSF K.V. Venkatachalam, Eileen Lafer, UTHSC, San Antonio Nova Southeastern University Proteomics and Bioinformatics How to Publish in the JBC Michael Snyder, Yale University Minorities and the HIV/ Presented by Associate Editors of JBC David S. Eisenberg, UCLA AIDS Epidemic Juliette Bell, Chemical Genetics and Fayetteville State University �� Drug Discovery • Herbert Tabor/Journal Chaitan Khosla, Stanford University EPD/MAC Symposium – Under- of Biological Chemistry Lectureship Kevan Shokat, UCSF graduate Student/Faculty Science • ASBMB-Amgen Award Joseph Provost, Glycobiology and Minnesota State University-Moorhead, • ASBMB Award for Exemplary Extracellular Matrix Mark A. Wallert, Contributions to Education Carlos B. Hirschberg, Boston University Minnesota State University-Moorhead • ASBMB-Merck Award Goldman School of Dental Medicine and Phillip A. Ortiz, • Avanti Award in Lipids Empire State College • FASEB Excellence in Science Award �� EPD/MAC Symposium – Outreach • Herbert A. Sober Lectureship Genome Dynamics: Replication, and Public Education • Howard K. Schachman Repair, and Recombination Neena Grover, Colorado College Public Service Award Laurie S. Kaguni, Michigan State Univ. • Schering-Plough Research Institute Award Chromatin: Structure, �� • William C. Rose Award Expression, and Regulation �� Sharon R. Dent, University of William R. Brinkley, Texas M. D. Anderson Cancer Center Baylor College of Medicine �� • Opening Centennial RNA: Structure, Metabolism, Teaching the Science of Evolution Celebration Reception and Regulation Under the Threat of Alternative Views • ASBMB/JBC Birthday Bash, Alan D. Frankel, UCSF William R. Brinkley, Ken Miller, A Taste of San Francisco Don Johanson, Eugenie Scott, Ted Peters Protein Synthesis, Folding • ASBMB 5k Fun Run and Turnover • An Evening with the William Merrick, �� San Francisco Symphony Case Western Reserve University �� Focus on the Future, Shape the Debate J. Ellis Bell, Univ. of Richmond �� ASBMB Centennial Clara Benson Metabolic Regulation Undergraduate Poster Session Travel Fellowship Award Richard W. Hanson, and Plenary Lecture: My Life in Science Graduate Minority Travel Award Case Western Reserve University Edmond H. Fischer, University of Graduate or Postdoctoral Daryl K. Granner, Vanderbilt Univ. Washington School of Medicine and Travel Award Edwin G. Krebs, University of Signaling in Growth and Washington School of Medicine Undergraduate Student Travel Award Development Undergraduate Faculty Travel Award Michael B. Yaffe, MIT Current Themes in Molecular Evolution Michael M. Cox, Signaling in Aging and Disease University of Wisconsin – Madison Natalie G. Ahn, �� University of Colorado at Boulder 10th Annual Undergraduate Student Plenary Lecture: Integrity and Research Achievement Award Poster Independence of Scientiﬁc Thought Competition, Saturday, April 1, 2006 Elizabeth Blackburn, UCSF �� ASBMB Graduate Student and Biochemistry and Molecular Postdoctoral Travel Award Matching Expectations: Biology of Lipids Symposium, Saturday, April 1, 2006 Employers and Education in the George M. Carman, Rutgers University Molecular Life Sciences ABRF/ASBMB Symposium Christian R.H. Raetz, Duke University Joy A. McMillan, Minority Scientists Mixer Madison Area Technical College Structure, Function, and Biogenesis Women Scientists’ Mentoring/ of Cell Membranes Networking Session and Reception The Classroom of the Future William Dowhan, University of Graduate Student and Postdoctoral J. Ellis Bell, Univ. of Richmond Texas-Houston Medical School Mentoring/Networking Session and Reception ASBMB Business Meeting

AbstractAbstract Deadline: Deadline: November February 8,2, 20062005 �� JANUARY 2006 ASCB NEWSLETTER 23 ANNUAL MEETING Highlights

Highlights, continued from page 22 Subcommittee on Postdoctoral tions in other countries due to strin- gent restrictions placed on stem Training cell research in the United States by the Bush Administration. What are stem cells, what kind of research is performed on these intriguing cells, and what is the heat of the con- troversy behind using these cells? Allan Spradling of the Carnegie Institution in Washington/HHMI Tracie Gibson of Purdue University introduces (left to discussed these and other issues dur- right) Christina Lewis of the University of California, ing the high school program. San Francisco, Postdoctoral Scholars Association; Jill Fuss of Lawrence Berkeley National Laboratory; and Approximately 350 students Keith Micoli of the National Postdoctoral Association. from schools around the greater San The Subcommittee on Postdoctoral Training Francisco Bay Area attended the presentation was titled Networking for Success: The presentation. It spanned Spradling’s Essence of an Effective Postdoctoral Association. unique introduction to fruit fly research in high school, his graduate Postdoctoral Society Committee, Lawrence and postdoctoral careers, and his Berkeley National Laboratory. The panelists ad- current work using fruit fly stem cells. dressed how postdocs can get involved in such Spradling explained how working with associations and how to tap into existing re- fruit fly stem cells is not controversial sources. like human stem cell research. He also Members of the subcommittee met separately to detailed some of his groundbreaking organize plans for next year’s Annual Meeting and results that provided a library of stem to appoint a new chair. Cherie Butts, a postdoctoral cell mutants to the Drosophila research fellow at the National Institute of Mental Health, community. After Spradling’s talk, will replace Tracie Gibson as chair. Laurie Littlepage students asked questions and were and Kristen Kwan have agreed to serve as co-vice escorted to the vendor exhibits and chairs. SCOPT plans to continue to expand its Over 3,000 posters were presented at the ASCB Annual Meeting. poster sessions. outreach to ASCB postdocs.

Subcommittee on WICB Workshop Postdoctoral Training Are scientists concerned with conflicts that might The ASCB Subcommittee on Postdoctoral affect their ability to perform professionally? Training (SCOPT) The highly interactive Women in Cell Biology WICB Workshop hosted a session at Workshop on Conflict Resolution held December the Annual Meeting 10, 2005, provided dozens of participants the op- Michael Milano of Murphy on “Networking portunity to learn how to go from conflict to con- & Milano, Inc., led the WICB Workshop on From for Success: The fidence and how to negotiate situations on a day- Conflict to Confidence: Essence of an to-day basis. Led by Michael Milano of Murphy Negotiating Day-to-Day Effective Postdoctoral & Milano Inc., attendees learned, among other Conflicts. Association.” things, that conflict is not an unusual situation, Members of the pan- that there are many styles to resolving conflict, el included Keith and that each individual needs to find a comfort- Micoli, National able and productive style that provides her or him Postdoctoral with confidence to resolve a conflict by working Association; Christina with others to achieve a resolution. Lewis, University of California- WICB Career Lunch San Francisco Approximately 400 people attended the Career Postdoctoral Scholars Lunch sponsored by WICB. The attendees se- Association; and Jill lected from 25 topics of interest, at 38 labeled ta- Fuss, Biosciences

24 ASCB NEWSLETTER JANUARY 2006 ANNUAL MEETING Highlights

WICB Evening Program Finding the Balance Between Over-Conﬁdence and the Imposter Syndrome

WICB Career Lunch Caroline Kane Committee Thespians included (left to right) Gary facilitated the Borisy, Lydia Villa-Komaroff, Randy Schekman and Evening Program. bles. The most popular topics included the “new- Matthew Welch. er” areas, such as Biotech & Pharmaceuticals, as well as the more “traditional,” Obtaining an Appropriate Postdoc Position, Job Application Strategies for Academic Positions, and Developing Your Career. From the animated discussions and an unofficial exit poll, it is clear that the Career Lunch continues to be a highlight for both the table leaders and registrants. Gary Borisy and Lydia Villa-Komaroff ... while Linda Hicke and Matt Welch WICB Thespians are getting into the seriousness of are having too much fun with their their roles ... The Impostor Syndrome was aptly dramatized dur- role-play. ing the Women in Cell Biology evening program by Committee Thespians Lydia Villa-Komaroff, Linda Hicke, Gary Borisy, Randy Schekman and Matthew Welch. They displayed the anguish, anxiety, and raw fear that come when you think others have an inflated opinion of your prowess. That is, your self-confidence is disconnected from the real- ity of your talent. The thespians also portrayed the flip side of the anxiety-prone suffering the Impostor Syndrome. That is, some colleagues may have a history of being “often wrong but never in doubt” (a phrase quoted from Ellen Goodman, a columnist at The Boston Globe). These individuals bombast their way through their own worries about being discovered as intellectual frauds. Perhaps the most telling observation from this evening program was the number of prominent members of the Society, including no fewer than six current and former Presidents, who remarked on their own anxieties surrounding these issues. They showed how they relied on caring mentors, friends and loved ones to begin to believe in their own talents. Clearly this year’s evening program struck a chord, touching a nerve in both men and women, junior and senior cell biologists. An article on the issue, penned by WICB member Sue Wick, can be found in Career Advice for Life Scientists, Volume 1. A workshop on the topic seems warranted at a future ASCB meeting. ■

JANUARY 2006 ASCB NEWSLETTER 25 ANNUAL MEETING Highlights

Minorities MAC Mentoring Symposium Affairs Committee Activities

Above left: Cherie Butts of the National Institute of Mental Health/NIH moderated the MAC Mentoring Symposium. At left: Bruce Alberts of the University of California, San Francisco, and George Langford of Dartmouth College spoke on Trailblazers and Path Finders: Secrets for Career Success from Leading Scientists. Above: Mentoring Symposium participants.

MAC Poster Session

MAC Poster Winners

Undergraduate First Place Dominick Lemas—University of Vermont, Burlington

Second Place Kiani Lopez—University of Puerto Rico, Mayaguez

Third Place Dwane Clark—Morgan State University

Graduate Awards First Place Sabrice Guerrier—University of MAC Poster organizers Peter Satir (far left) and Anthony DePass (far North Carolina, Chapel Hill right) with MAC poster session winners (left to right) Dwane Clarke, Mauricio Cortes, Kiani Lopez, Anthony Aragon, Veronica Lopez, Sabrice Second Place Lymarie Maldonado-Baez— Guerrier, Lymarie Maldonado-Baez, and Juan Reyes. The Johns Hopkins University

Third Place Mauricio Cortes—University of Chicago Anthony Aragon—University of New Mexico, Albuquerque Juan Reyes—Chicago State University

Postdoctoral Fellows First Place Alexis Rodriguez—Albert Einstein School of Medicine

Second Place Veronica Lopez—University of California, Davis MAC Poster presenters: James Olzmann (left) of Emory University and Omayra Rivera-Denizard of the University of Puerto Rico, Mayaguez Faculty Awards (right), present their research. Omar Quintero—Franklin and Marshall College Underepresented Minorities/Council Roundtable Discussion

26 ASCB NEWSLETTER JANUARY 2006

ANNUAL MEETING Highlights

28 ASCB NEWSLETTER JANUARY 2006

��

�� PUBLIC POLICY Brieﬁng

Historically Bad Budget for NIH In the final hours before U.S. Congress ad- A Conference Committee of both House and journed for 2005, Congress completed its Senate members included a budget of $28.526 work on the FY 2006 Departments of Labor, billion for the NIH in the final version of the Health & Human Services and Education budget bill. This is $252 million or 0.9% above Appropriations bill. This bill includes fund- the 2005 NIH budget. In an unusual move, ing for the National Institutes of Health (NIH). however, the Conference Report was rejected Unfortunately, the budget does not include by the full House of Representatives. After good news for the NIH. A making changes to the bill small funding increase in The growth of the not connected with the NIH, the Appropriations bill com- a second Conference Report bined with a 1% government- NIH budget has was narrowly approved by wide budget cut will result in steadily decreased the House by only two votes a 2006 NIH budget that is and later by voice vote in the $33 million less than the 2005 in each of the three Senate. After the government- budget. The NIH has not seen federal budgets wide 1% reduction, the final a cut in its budget since 1970 NIH budget will end up at when President Nixon cut the since the 2003 $28.241 billion. budget by $48.8 million. completion of the The growth of the NIH President Bush’s original five-year doubling budget has steadily decreased budget proposal included a in each of the three federal request of $28.418 billion of the NIH budget. budgets since the 2003 for the NIH which was completion of the five- $144 million or .5% more year doubling of the NIH than the final 2005 NIH budget. The House budget. In each of those years, the increase of Representatives budget included $28.515 has been below the Biomedical Research and billion, an increase of $241 million or 0.8% Development Price Index (BRDPI), an index above the 2005 NIH budget. The Senate bill intended to provide a more precise gauge of the included $29.323 billion for NIH, $1.049 resources necessary to keep up with inflationary billion or 3.7% more than last year’s budget. costs particular to biomedical research. ■

JANUARY 2006 ASCB NEWSLETTER 31 Court Says ID Is Not Science A U.S. District Court judge has ruled that explanation on every point should not be used “Intelligent Design” cannot be taught in Dover, as a pretext to thrust an untestable alternative Pennsylvania, biology classes. The ruling is the hypothesis grounded in religion into the science result of a court case filed against the Dover Area classroom or to misrepresent well-established School Board by parents of 11 students after the scientific propositions.” Board voted to amend the school biology cur- Jones was equally blunt in his criticism of riculum. The new policy required that a state- the Dover School Board and the proponents of ment be read in each ninth grade biology class Intelligent Design. He charged that the citizens stating that Darwin’s Theory of Evolution is of Dover “were poorly served by the members of “not a fact” and has inexplicable “gaps.” ASCB the Board who voted for the ID Policy.” In his member Ken Miller was the first witness for the harshest words, the judge said, “It is ironic that plaintiffs. several of these individuals, who so staunchly In his ruling, U.S. District Court Judge and proudly touted their religious convictions in John E. Jones III wrote that, “In making this public, would time and again lie to cover their determination, we have addressed the seminal tracks and disguise the real purpose behind the question of whether ID is science. We have ID Policy.” concluded that it is not, and moreover that ID While this ruling applies only to the Dover cannot uncouple itself from its creationist, and Area schools, it may have a major impact on thus religious, antecedents.” efforts to include ID in the science classes of Judge Jones continued, “To be sure, Darwin’s other school systems around the U.S. theory of evolution is not perfect. However, the To read the complete ruling, go to http://coop. fact that a scientific theory cannot yet render an www.uscourts.gov/pamd/kitzmiller_342.pdf. ■

Creationism Monitor

The State of State Science Standards Thomas B. Fordham Institute www.edexcellence.net

32 ASCB NEWSLETTER JANUARY 2006

DEAR Labby

Dear Labby, I am writing to you in an anxious state of mind. I am a 36-year-old Assistant Professor of Cell Biology and this is my tenure review year. I am at a pretty good institution, though not one of the real Ivory Towers. Things have gone quite well for me but my Department Chair told me last summer that my tenure decision could be a close call because my publication record is “just a bit short.” Her comment refers to the fact that although I have published an average of 2.5 papers a year in two leading cell biology journals (MBC and JCB), I have yet to publish in one of the so-called “elite” journals. I don’t want to get into the controversies about Impact Factors, etc. I have a more specific question. Last year, I submitted what I consider my most important paper so far to one of the “elite” journals and received what I regard as very positive reviews. Nonetheless, the editor turned my paper down. I appealed but the editor dug in her heels. When I assembled materials for my tenure review, I wanted to include the two referees’ enthusiastic reviews on the aforementioned manuscript, but my Chair advised me not to do so. Now I wonder if that was the right decision. If the Tenure and Promotions Committee saw how close my paper came to being accepted in the “elite” journal, maybe that would be an influential factor—perhaps a decisive one? By the way, on the other tenure criteria, teaching and service, my Chair said I am fine. —Worried

Dear Worried, Labby would have recommended inclusion of the referee reports—why not? There is no apparent downside. Did your Chair think members of the committee would be turned off knowing that an “elite” journal turned down your paper? It sounds like she was trying to protect you but it may have been overdone. It is likely that every member of the committee has had this experience (Labby certainly has) It might also have been useful to include the editor’s letter, explaining the rejection. The editor must have pulled out a major issue in order to traverse two very positive reviews. (But bear in mind that you have not seen the referees’ confidential comments to the editor, and these can sometimes be very different from the tone of the reviews—a totally corrupt practice Quality Calibrations Inc but it happens.) You have high marks in two other categories, teaching and Pipette Repair Service service, and at most good institutions these do count. And your research productivity sounds extremely good, more like A- (at least) Comprehensive Pipette Service — On Site and Mail-In than warranting your Chair’s “close call” remark. The two journals you are publishing in (at a frequency higher than many established, famous labs) are extremely well regarded. Calibrations ■ Repairs ■ Replacement Parts ■ Certificates of Calibration To paraphrase a line from the great reggae song: “Everytin’s almost certainly gonna be all right.” But your experience does raise an interesting issue, and hopefully airing it here will be helpful to Service Available on all Pipettes - Single Channel, ASCB members (either pre-tenure faculty or Chairs, as there are Multi-Channel and Electronic teachings for both). Labby looks forward to the news of your grant of tenure. Customized services to meet customer’s laboratory —Labby ■ requirements and budget Direct your questions to [email protected]. Authors of questions On Site Service available in MD, DC, DE, VA, NY, CT, PA, chosen for publication may indicate whether or not they wish to OH, NJ, MA, NC, SC, AL, TN, AZ, CA be identified. Submissions may be edited for space and style.

Woman-owned small business successfully serving the Bio- tech Research Industry since 1991

TOLL FREE (877) 747-3883 or (800) 846-0034

34 ASCB NEWSLETTER JANUARY 2006 ASCB Profile Peter Satir “It came to me as I was walking down Second worked like a charm, Satir recalls, yielding a Avenue,” Peter Satir recalls. It was 1959. Satir bountiful supply of samples. “I was able to was on his way back to work as a graduate stu- describe some ultrastructural changes but when dent in Keith Porter’s electron microscopy lab- you look carefully at ultrastructure, it’s actually oratory in what was then called the Rockefeller much more difficult to know what is going on. Institute in New York. The problem on Satir’s I didn’t really figure it out until 1964 when I mind was cilia and whether they moved by con- realized that by studying the tips of cilia, I could tracting or by sliding the structures we now call actually see whether the microtubules contract microtubules. Satir’s experimental epiphany was or slide when they bend.” the idea of stopping a metachronal wave in its We know today that microtubules do tracks. The cilia that line the gills of freshwater slide along and so much more about the mussels beat in metachronal waves, each cilium ultrastructure underpinning cell motility

just out of phase with its neighbor. If Satir could because of Peter Satir’s pioneering work, Peter Satir “fix” a wave instantaneously, he would capture according to Win Sale. An early Satir graduate cilia in every stage of the beat cycle from the ef- student, Sale is now at Emory University fective to the recovery position. A blast of OsO4 Medical School. Satir’s proof of sliding was fixative would do it, Satir calculated. It would especially elegant, says Sale. Satir hypothesized chemically freeze the wave and preserve each cil- that, “If microtubules were inextensible, then ium for serial cross-sectioning and close study based simply on the geometry, microtubules on under the electron microscope. “Or at least that the inside edge of a bent axoneme (one of the was my idea,” Satir says. nine doublet microtubules bundled around the His Eureka moment on Second Avenue took cilium perimeter) must extend beyond those five years to unfold. The fixative flash-freezing on the outside. Peter reasoned that microtubule

JANUARY 2006 ASCB NEWSLETTER 35 displacement could be identified in the pattern involved in the formation of ASCB’s Minorities of microtubules at the tips of cilia.” Satir Affairs Committee (MAC). Two years ago, used a geometric model of a circular bending Satir agreed to rejoin MAC. “There’s a lot more arc to predict the angle between inside and activity on MAC and a much wider perspective outside axonemes, that is, if microtubules did on the issues today,” says Satir.”I originally got slide. Satir’s model, the EM images and the involved because of Winston Anderson,” says measurements matched precisely, says Sale. Satir. “It was Winston who really got MAC That work and Satir’s subsequent discovery of going when he brought in the first grant to the minus-end polarity of the dynein protein organize the Woods Hole minority program.” were critical to the cell motility revolution that Peter Satir was born in Manhattan but grew “Satir has … had continues to this day, says Sale. up a proud product of the Bronx, educated Satir has also had a tremendous impact on in the public schools and a graduate of the a tremendous cell biology through the generations of scientists famed Bronx High School of Science. As an impact on cell he has trained, Sale adds. “I took his cell biology undergraduate at Columbia, Satir fell under class at Berkeley so I was still an undergraduate the influence of cell physiologist Teru Hayashi. biology through when I went to ask if I might be able to do some “Of course, my parents wanted me to become the generations research work in his lab. And Peter said, ‘By all a doctor but I had no interest in becoming a means! Come in and we’ll find you something to physician,” Satir recalls. “Fortunately, Columbia of scientists he do.’ That’s how I started in electron microscopy had all incoming students take aptitude tests. has trained.” but it was later as his graduate student that I My advisor called me in and said, ‘Whatever really began to understand Peter’s vision of what you do, don’t apply to medical school. You research could be about.” have absolutely no aptitude for medicine.’ This Soren Christensen was a Satir post-doc at was a great relief to me as I could call up my Einstein from 1998 to 2000. “It was my best mother and tell her that my advisor strongly place ever,” says Christensen who is now at recommended against it.” the University of Copenhagen. “Peter is such Free to pursue his research interests, Satir a warm, gregarious person but he also knows followed his mentor, Hayashi, to Woods Hole how to grow scientists. He allows new students in the summer after his senior year to audit the to think for themselves. He gives you a certain MBL Physiology Course and hear Keith Porter’s freedom and then he supports you in every way Harvey Lecture on the wonders of electron he can. So now I send my students to Peter’s microscopy. He joined Porter’s lab at Rockefeller lab. He is not only a colleague but still a very as a graduate student in 1956. In those early important mentor for me.” years, Rockefeller graduate program strongly Christensen says that Satir’s scientific urged (and underwrote) a year’s fellowship in an influence has been particularly strong in overseas lab. Satir spent 1958 in Copenhagen as Denmark through Satir’s fellowships in a fellow in Erik Zeuthen’s lab, one of only a few Copenhagen labs, his mentoring of Danish in the world then studying the cell cycle, mainly students in the Bronx, and his marriage to by synchronizing cell division in Tetrahymena. Birgit Hegner, who among many other things Satir returned to the Rockefeller and his Second is a Fellow of the Royal Academy of Science Avenue epiphany about the ultra structure Driving in her native land. Peter Satir’s influence was of cilia the following year but his Danish recognized last November by an honorary connections flourished, especially after he everything was doctorate from the University of Copenhagen convinced Birgit to see what American science Satir’s hunger and a reception by Queen Margrethe II. had to offer. They married in 1962, soon after According to Christensen, “It was quite an Peter took his first position at the University of for new data and event.” A ceremony at the University was Chicago. new insights. followed by a formal reception with the Queen In truth, American academic science had and later by a performance at the new Opera very little to offer married couples in the early House. “Peter speaks almost fluent Danish so he 1960s. Fierce departmental “anti-nepotism” was able to converse with the Queen about his rules doomed one scientific spouse, usually work,” Christensen adds. the woman, to a non-salaried bench or an Though Satir didn’t mention this honor, appointment elsewhere. Birgit and Peter Satir he can be forgiven as his CV has a lot to became career trailblazers in 1967, when the cover. Among other things, Satir was at the Physiology Department at Berkeley made them first meeting of the ASCB in 1961 where he its first-ever double job offer. Birgit was not remembers giving a cilia paper at Edgewater fully salaried, Peter remembers, but she had her Beach Hotel in Chicago. In the 1970s, Satir was own appointment, and eventually her own lab.

36 ASCB NEWSLETTER JANUARY 2006 When the Satirs left Berkeley for the Bronx in than for you to come in there with a stack of new 1977, Peter says that a major enticement was the EMs. He’d drop everything, clear a space and full double appointment, salary and lab space go through them with you, one by one. He just offer from Albert Einstein. The move was also couldn’t resist.” poetic revenge for Satir’s mother. Her son with Salisbury continues, “I can’t emphasize this no aptitude for medical school was now Chair too much but a major part of Peter’s strength as a of Anatomy at the Albert Einstein College of scientist is that he has Birgit as a partner. The two Medicine. The move also brought Satir full of them have an interesting balance to life. They circle in the Bronx. His family’s old apartment banter back and forth constantly but always in a was only blocks from his new office. very positive way. They are unique.” “A major part of The Satir labs have drawn a steady stream Today the Satirs live in Greenwich, of talent to Einstein, including Jeff Salisbury Connecticut. The elder son, Jakob, is a computer Peter’s strength who was finishing his doctorate at Ohio State in programmer in Florida and the father of as a scientist is 1978 when he accepted an invitation from Satir Anthony, their only grandchild, so far. Their that he has Birgit to come see him in the Bronx. A long train, other son, Adam, is a personal banker in Spain. subway and bus ride later, Salisbury wondered The Satirs have no plans to retire anytime soon, as a partner …. if he’d ever find his way home. The journey was says Peter Satir. He is especially energized these They are unique.” worth the effort, says Salisbury who is now at days by the “renaissance” in ciliary biology the Mayo Clinic Medical School. “I stayed there following recent discoveries linking mutations in the Bronx for six years and gained 30 pounds in primary cilia to polycystic kidney disease which I haven’t lost since. Part of that was Peter. (PKD). “It’s really taken off because of the disease He loves life. Not only did he teach me a lot of relevance,” says Satir, “but it’s not just PKD and great science, he taught me how to eat.” the kidneys. It seems to be involved as a growth Driving everything was Satir’s hunger for new control mechanism almost everywhere that there data and new insights, Salisbury recalls. “Peter’s are primary cilia. There isn’t any reason to retire. office door was always open. No matter what I’m having a great time.” ■ he was doing, there was nothing he liked better

JANUARY 2006 ASCB NEWSLETTER 37

WOMEN in Cell Biology Science Education in America: What to Do? Judge John Jones III released his eloquent must test student knowledge of science starting verdict refuting the presentation of intelligent in 2007-2008. While we did not quantify this design creationism (IDC) in public-school impression, our panel noticed that the standards science classes. And the brilliant testimony of that were deemed meritorious were often ones Kenneth Miller, chair of the ASCB Education that listed scientists as participants in their Committee, makes for particularly wonderful drafting. Should any of you wish to consider reading (www2.ncseweb.org/wp/?p=39). It does volunteering input for future drafts, please email not follow, unfortunately, that U.S. K-12 science me at [email protected]. I’ll try to be of education is thereby out of the woods. assistance. This year I joined five other scientists to Of primary concern is that students come review the 50 State Science Standards in a to understand and appreciate both how science project funded by the Fordham Foundation. is done and some of what scientific inquiry has Our report, which includes a state-by-state discovered. But I have an ancillary concern assessment, can be found at www.edexcellence. as well. The ancillary concern is that science net/foundation/publication/publication. education, both as articulated in the standards cfm?id=352. More can be found in the Public and as practiced in our schools, basically fails Policy section of this Newsletter. to convey to students what can be called the What we found was troubling to us, both as scientific worldview -- a narrative account, with parents and as scientists. Only 19 states have supporting empirical evidence, of our current produced standards that we would regard as understandings of the origins and evolution meritorious (as parents, we would be satisfied of the universe, the planet, and life (including to have our children educated humans) -- a worldview based in such contexts). Sixteen on the findings of the historical states’ standards, however, were sciences. One can find material highly flawed, and 15 were “Sixteen states’ on the Big Bang and stars flat-out unacceptable. In some standards … were in some physics classes, and cases a lackluster presentation material on plate tectonics “… our panel of evolution contributed to highly flawed, and in some geology classes, and noticed that the a poor outcome. But the 15 were flat-out (usually) some units on fossils standards that dominant and unsurprising unacceptable.” and evolutionary theory in pattern was that states with some biology classes. But no were deemed weak standards overall attempt is made to bring the meritorious were were also weak in evolution historical sciences together into education. Moreover, we a comprehensive framework in often ones that understand that teachers often tend to “skip over the way that American History classes would listed scientists the evolution sections” so as to avoid conflict— offer an overview of 400 years of U.S. history. in some cases, conflict with their own views. It’s my view that a presentation of such a as participants in Probably like most of you, I had at best a comprehensive scientific framework could help their drafting.” vague notion that such standards existed and ameliorate the epidemic of scientific illiteracy in had certainly never read one. But I encourage our society. As things now stand, K-12 students curious American readers to go to www. in science classes hear about cells one day and edexcellence.net/sciencestandardslinks.html, atoms the next. But they lack opportunity or click on your state, and discover how the guidance to integrate these understandings into teaching of science is presented. larger contexts. While this is not a problem for If this exercise confuses, bewilders, and/or the “science types” who soak up cells and atoms discourages you, you may wish to get involved. no matter what, it’s the others who concern me. These documents undergo frequent rounds of Most students find science classes tedious and revision. Moreover, the current version of the boring and drop out as soon as they’ve met the No Child Left Behind Act requires that states requirements.

40 ASCB NEWSLETTER JANUARY 2006 I’ve come to hold this view because I co-teach a course at the college level, with a physics and a geology professor, called the Epic of Evolution: Life, Earth, and the Cosmos. This MEMBER Gifts class presents the scientific worldview to science-disaffected students who take it as a distribution-requirement option. They The ASCB is grateful to the following members who have recently given a report that their interest in, and mastery of, scientific concepts gift to support Society activities: is greatly enhanced when such larger contexts are provided. Jacquelyn J. Maher We’ve become convinced that a robust and mindful grasp of the Robert S. Adelstein scientific worldview generates a more abiding commitment to Qais Al-Awqati Tadashi Maruyama scientific inquiry, to environmental sustainability, and to societal Jean-Marie Beckerich Christine R. Montague responsibility. Many students report an appreciation for the Daphne Blumberg Kathleen Slone Morgan scientific enterprise that was lacking when research was presented B. R. Brinkley Carmela Pasternak solely as the “engine” for technological advancement. They Keith W. T. Burridge Bernard Pollara also report that an understanding of their own lives in the vast Grace M. Donnelly John R. Pringle evolutionary context that made those lives possible instills a new Caroline A. Enns Evelyn S. Ralston and valuable framework for existential orientation and informed Laurence D. Etkin Laura S. Rhoads environmental awareness. Even our graduate-student teaching Thomas Baer Friedman Mary K. Rundell assistants invariably express appreciation for having been exposed Daniel S. Friend Carolyn D. Silflow to the “big picture” in a rigorous and memorable way for the first Joseph Gall Clifford J. Steer time. Gary Ian Gallicano Richard J. Stenger Obviously, the introduction of such a perspective into K-12 Darrel E. Goll Donna Beer Stolz education is a vast project that few of us can yet directly influence. Krisztina Hegyi Kelly Tatchell But I warmly encourage you to consider offering such a course at Catherine S. Hibbert Richard D. Veenstra your college or university. Please email me at [email protected] if Vincent W. Hollis Barbara M. Vertel you’d like to learn more about what we do. ■ Elizabeth Kordyum Peggy Weidman —Ursula Goodenough Wayne I. Lencer Michael Wise Alastair Mackay

JANUARY 2006 ASCB NEWSLETTER 41 MEMBERS in the News

Wolfgang Baumeister of the Max Planck Institute, an Elaine Bearer of Brown University, an ASCB mem- ASCB member since 1997, was awarded the 2005 ber since 1981 was named a 2005 Dart Scholar in Harvey Prize in the ﬁeld of Science and Technology. Learning and Memory, sponsored by a grant from the Dart Neuroscience Limited Partnership and was also named a Moore Distinguished Scholar at Caltech.

Ronald Breaker of Yale University/HHMI, an ASCB Guo-Qiang Bi of member since 2004, received the Eli Lilly and the University of Company Research Award from the American Society of Pittsburgh, an ASCB Microbiology. member since 1994, Robert Morris of Wheaton College, an ASCB member Guo-Qiang Bi Robert Morris Jason since 1990, and Swedlow Guy Caldwell of the University of Alabama, an ASCB Jason Swedlow member since 1992, was named the state’s 2005 of the University of Dundee, an Professor of the Year today by the Carnegie Foundation ASCB member since 1994, were among the 2005 for the Advancement of Teaching and the Council for fellows to conduct research at the MBL. Advancement and Support of Education.

Brian Druker of Oregon Health & Science University/ Stephen Elledge of the Brigham and Women’s HHMI, an ASCB member since 2002, won the 2005 Hospital/HHMI, and ASCB member since 1993, re- Robert Koch Award from the Robert Koch Foundation. ceived the Hans Sigrist Award from the University of Bern, Switzerland.

William Green of the University of Chicago, an ASCB H. Robert Horvitz of the Massachuesetts Institute of member since 1995, has received a 2005 Grass Technology/HHMI, an ASCB member since 1988, won Faculty Awards at the MBL. the 2005 Alfred Knudson Award from the National Cancer Institute.

Liqun Luo of Stanford Mark Warchol of Washington University, an ASCB University/HHMI, an member since 2004, has received a 2005 Grass ASCB member since Faculty Awards at the MBL. 2005, Joshua Sanes of Harvard University, an ASCB member since Liqun Luo Joshuan Ronald 1996, and Ronald L. Schnaar Sanes Schnaar of the Johns Hopkins University ASCB Members Elected to School of Medicine, an ASCB member since 1982, were among the researchers to receive the 2005 Senator Jacob Javits Award from the the American Society for National Institute of Neurological Disorders and Stroke. Microbiology

Nedra Wilson, an an ASCB member since 1992, received an academic appointment at Oklahoma State University. Wilson joined the OSU College of Osteopathic Medicine as Assistant Professor of Anatomy and Cell Biology.

Claire Fraser Kathryn V. Holmes Craig B. Thompson The Institute for University of University of Genomic Research Colorado Health Pennsylvania Member since 2005 Sciences Center Member since 1997 Member since 1969

42 ASCB NEWSLETTER JANUARY 2006 ASCB Members Elected AAAS Fellows Fourteen members of the ASCB were among those elected Fellows to the American Association for the Advancement of Science.

Peter Agre James Garrels Leslie Leinwand Jim Jung-Ching Lin Berl Oakley Louise Prakash Satya Prakash Duke University Garbrook Associates University of Colorado, University of Iowa Ohio State University University of Texas University of Texas Member since 1988 Member since 1992 Boulder Member since 1980 Member since 1979 Member since 2005 Member since 2005 Member since 1988

Patricia Pukkila Andrej Rotter Sandra Schmid David Soll Margaret Werner- H. Steven Wiley Meng-Cao Yao University of North Ohio State University Scripps Research Institute University of Iowa Washburne Pacific Northwest Meharry Carolina at Chapel Hill Member since 1990 Member since 1990 Member since 1984 University of New Mexico National Lab Fred Hutchinson Member since 1976 Member since 1990 Member since 1987 Cancer Research Center Member since 1978

JANUARY 2006 ASCB NEWSLETTER 43 The American Society for Cell Biology 2006 Call for Nominations

Bruce Alberts Education Award Early Career Life Scientist Award Who is Eligible: An individual who has received a doctorate since 1993 and has served as Who is Eligible: An individual who has demonstrated innovative and sustained contribu- an independent investigator for no more than seven years. The primary nominator must be tions to science education with particular emphasis on the local, regional and/or national a member of the ASCB but the candidate and support letter authors need not be. impact of the nominee’s activities. The primary nominator must be a member of the ASCB but the candidate and support letter authors need not be. How to Apply: Provide the candidate’s CV, a brief research statement and a nominating letter plus no more than three letters of support, at least one of which must come from How to Apply: Provide a letter of nomination, letters of support and CV. outside the candidate’s current institution. Award: The winner is presented a plaque and will give remarks at the 46th ASCB Annual Award: The winner gives a lecture at the 46th ASCB Annual Meeting. Expenses to attend Meeting. Expenses to attend the Annual Meeting are paid. the Annual Meeting are paid. Deadline: March 31. Deadline: March 31.

Merton Bernfield Memorial Award Public Service Award Who is Eligible: An outstanding graduate student or postdoctoral fellow who has excelled Who is Eligible: An individual who has demonstrated outstanding national leadership in in research. support of biomedical research. Any ASCB member may submit a nomination. The award winner may but need not be a scientist. How to Apply: The student or post-doc or their advisor should submit a one-page research statement, a list of publications, a copy of the abstract submitted to the current year’s How to Apply: Provide a letter of nomination with a description of the nominee’s advocacy Annual Meeting, and the advisor’s letter of recommendation. Post-docs may also submit the for and promotion of scientific research. recommendation of their graduate student advisor. Duplicate applications from graduate students may be submitted for the Gilula and Bernfield Memorial Awards. Award: The winner gives the Public Service Award Lecture at the 46th ASCB Annual Meeting and receives a certificate. Expenses to attend the Annual Meeting are paid. Award: The winner speaks in a Minisymposium at the 46th ASCB Annual Meeting and receives an honorarium. Expenses to attend the Annual Meeting are paid. Deadline: March 31. Deadline: August 1.

Norton B. Gilula Memorial Award E.E. Just Lectureship Who is Eligible: An outstanding graduate or undergraduate student who has excelled in re- Who is Eligible: A minority scientist who has demonstrated outstanding scientific achievement. search. The primary nominator must be a member of the ASCB but the candidate need not be. How to Apply: The student or advisor should submit a one-page research statement, a list How to Apply: Provide a nomination letter with a description of the nominee’s scientific of publications, if any, the abstract submitted to the current year’s Annual Meeting and the achievement and mentoring support of underrepresented minority students and scientists. advisor’s letter of recommendation. Duplicate applications from graduate students may be submitted for the Gilula and Bernfield Memorial Awards. Award: The winner gives the E.E. Just Lecture at the 46th ASCB Annual Meeting, and receives a plaque. Expenses to attend the Annual Meeting are paid. Award: The winner is presented a plaque. Expenses to attend the Annual Meeting are paid. Deadline: March 31. Deadline: August 1.

MBC Paper of the Year Award E.B. Wilson Medal Who is Eligible: A student or post-doc first author who published the best paper in Who is Eligible: An individual who has demonstrated significant and far-reaching contri- Molecular Biology of the Cell from June 2005 through May 2006. butions to cell biology. The primary nominator must be a member of the ASCB but the candidate need not be. The E.B. Wilson Medal is the ASCB’s highest award for science. How to Apply: Submit your best work to MBC. The winner is determined by MBC Associate Editors. All papers are considered; no additional application or nomination is How to Apply: Provide the candidate’s CV and no fewer than three and no more than five required or invited. letters of support.

Award: The winner speaks in a Minisymposium at the 46th Annual Meeting. Expenses Award: The winner gives the E.B. Wilson Lecture at the 46th ASCB Annual Meeting, and to attend the Annual Meeting are paid. receives the E.B. Wilson Medal. Expenses to attend the Annual Meeting are paid.

Deadline: Associate Editors make recommendations by June 18. Deadline: March 31.

WICB Career Recognition Award All applications and nominations Who is Eligible: The Junior Award is for a woman in an early stage of her career (assistant pro- may be submitted to: fessor or equivalent) who has made exceptional scientific contributions to cell biology and exhibits the potential for continuing a high level of scientific endeavor while fostering the career devel- The American Society for Cell Biology opment of young scientists. The Senior Award is for a woman or man in a later career stage (full 8120 Woodmont Avenue, Suite 750 professor or equivalent) whose outstanding scientific achievements are coupled with a long-stand- ing record of support for women in science and mentorship of young scientists. Bethesda, MD 20814-2762 How to Apply: For the Senior Award, provide a letter of nomination, CV of the candidate [email protected] and a maximum of five letters of support. For the Junior Award, provide a letter of nomina- For names of prior awardees or more information, see tion, CV of the candidate, and a maxiumum of three letters of support. www.ascb.org or contact the ASCB at (301) 347-9300, or Award: The winners are presented an honorarium and plaque at the 46th ASCB Annual [email protected]. Meeting. Expenses to attend the Annual Meeting are paid. Deadline: March 31.

44 ASCB NEWSLETTER JANUARY 2006

New Members

The ASCB Council admitted 1,455 new members and granted Emeritus status to nine members of the Society last month:

Khadar M. Abdi Eddie Bautista Carlos A. Castro Jose F. Covian-Nares Anthony W. Essex Amir Goldkorn Alireza Abdolmohammadi Jordan R. Beach Rodrigo Orlandini Castro Rebecca Anne Cowling Luis D. Estévez-Salmerón Inna N. Golubovskaya Wassim G. Abou Kheir Andrew Richard Beardsley H. Dwight Cavanagh Braden D. Cox Osigwe Esue Maria Adelaida Gomez Suraj Abraham Anthony O. Beas Juliane P. Caviston Madeleine Lisa Craske Helge Ewers Alexandr M. Goncharov Russell C. Addis Marta K. Bechtel Jitka Cejkova Alexis Kohnstamm Crow Alexander H. Farley Delquin Gong Amit Shrikant Adhikari Daniel Becker Brian P. Ceresa Sara Eustace Crumm Rizwan Farooqui Yixuan Gong Nassiba Adjerid Angela Beckett Santanu Chakraborty Zobeida Cruz-Monserrate Helen Katherine Farr Sailesh Gopalakrishna Pillai Silvia Agostini Benjamin L. Beckstead Anna H. Chan Charles Cuerrier Kelly E. Fathers Gabriel M. Gordon Ramses M. Agustin Babak Bedayat Srikripa Chandrasekaran Ping Cui Nicole Faust Julian X. Gordon Kashif Adil Ahmad Michael Frank Beil Dilip Chandu Zhengfang Cui Constance Y. Fears Jessica A. Gorski Nesar Ahmed Greg J. Beitel Eun-Ju Chang Ognjen Culic Timothy N. Feinstein Grace A. Goschke Katja M. Aho William J. Belden Il-Chi Chang Francisco J. Cullere-Luengo Edward A. Felinski Moloy Goswami Taby Ahsan Olivier Belzile Jennifer Chang Kathryn D. Curtin Ying-Hong Feng Cristian Gradinaru Erkang Ai Jacqueline M. Benjamin Jihoon Chang Christin Ann Cvetic Barbara Murray Fenner Michel Grandbois Fumiko Aikawa Craig L. Bennett Te-Hung (Leo) Chang Bruno Da Rocha-Azevedo Gabriel Fenteany Colin G. Grifﬁn Lakkureddi Alagarsamy Ahmi Ben-Yehudah Jui I. Chao Sepehr Dadsetan Matthew L. Ferguson Eva-Maria Sarah Grimm- Suresh K. Alahari Emanuela Benzoni Robert S. Chapkin Shipan Dai Michael J. Ferkowicz Günter Nael H. Alami Jeffrey M. Bergelson Vandhana M. Chari Zonghan Dai Cristina C. Fernandez Matthew C. Groll Kristin L. Albert Lloyd C. Berger Kanokwan Charoonpatrapong Sashko Damjanovski Rodrigo Fernandez-Gonzalez Alberto Grossi Hector Aldaz Gabriele Bergers Raghava V. Charya Savita V. Dandapani Ester Fernandez-Salas Ingrid Gsandtner Bree Beardsley Aldridge Ian C. Berke Bithi Chatterjee Thao Dang Micah Jered Ferrell Chen Gu Stefano Alema Jessica Berthold Ovijit Chaudhuri Alexes C. Daquinag Andrew Douglas Ficzycz Zhizhan Gu Paula M. Alves Arnaud Besson Tathagata Chaudhuri Mainak Das Gero Helge Fink Yingjie Guan Amr A. Amin Craig M. Betts Philippe Chavrier Sudipto Das Carla V. Finkielstein Zeqiang Guan Xiuli An Jennifer P. Bharucha Aditi Chawla James R. Davenport Alyson A. Fiorillo Dominique Guerette Aikaterini Anagnostopoulou Rajat Bhattacharya Baozhi Chen Sandra M. Davern Ronald R. Fiscus Robert D. Guettler Vikram C. Anand Pankaj Bhumireddy Catherine Chen John S. Davis Terry Fitzpatrick Nilanjan Guha Allan Atienza Ancheta Xiaoning Bi Chiung-Ya Chen Sandra De Keijzer Brendan Flaherty Sandra Guilmeau P. Kumari L. Andarawewa Sergei Bibikov Christine Yeihua Chen Heidi E. De Luca Marta Flandez Huazhang Guo Nicholas J. Andersen Ainsley E.D. Bigg Hsuan-hsu Chen Alicia B. De Maria Roberto Pingol Flores Neetu Gupta Parker L. Andersen Amber E. Bilak Hueih Min Chen Ann M. De Maziere Kevin C. Flynn Vijay Gupta Thomas Ettore Angelini Israel Biran Ihsiung Brandon Chen David De Semir Nicole Foeger Cemal Gurkan Wolfram Antonin Jonathan E. Bird Liang Chen Tara Lynn Deans Alla F. Fomina Eric A. Gustafson Edna E. Aquino Monique D. Birger Nien-Tsu Chen Marcus O. Debiasi Polly M. Fordyce Nicholas R. Guydosh Victoria Aranda Cheryl L. Birmingham Qian Chen Agnes Genevieve Delaunay Michael S. Foulk Jeongim Ha Rajesh Arasada Jason Edward Black Shu-Fen Chen Violaine D. Delorme Anne Fourest-Lieuvin Tara L. Haas Luis E. Arias-Romero Evelyne Bloch-Gallego Xueni Chen Agnieszka M. Demczuk Danielle Cook France Thomas C. Haberberger Jyothi Arikkath Vincent Blot Yi Chen Paula B. Deming Isabelle Frechette Olivier Hachet Ayelet Armon-Omer Ann-Marie B. Bolger Catherine Q. Cheng Daryle J. Depianto Eric O. Freed Angela T. Hahn Lourdes Andrea Arriaga- Ewa Borowczyk Chiang-Min Cheng Merran C. Derby Melanie Mae Frigault Sarah Elizabeth Haigh Pizano Maegen A. Borzok Lina Cheng Celine DerMardirossian Lillian K. Fritz-Laylin Anders P. Hakansson Gustavo Arrizabalaga David C. Bouck Nai-Lin Cheng Kathleen Lee Derrick Enrique Fuentes-Mattei Ben A. Hall Gerardo Arroyo Emer Bourke David Chereau Parima Desai Hideaki Fujita Takahiro Hamada Haruhiko Asakawa Kevin M. Bourzac Peter S. Cheslock Ravi Anand Desai Kenji Fukasawa Lisa P. Hammerle Charles L. Asbury Amy H. Bouton John R. Chevillet Nirupama S. Deshpande Aline Harumi Fukuzawa Jennetta Watson Hammond Angela L. Asirvatham Susan D. Bowers Susan Chi Marguerite Marie Desko Brie Katherine Fuqua Cheri M. Hampton Sirisha Asuri Susie Boydston-White Christine M. Chiasson Shankar Devasenathipathy Elizabeth J. Furnish Hsiao-Fen Han Syed Atif Abbas Scott N. Boyle Andy J. Chien Vikram Devgan Brian G. Gabrielli Ka-Hyung Han Rajith Nandana Aturaliya Matthew R. Bozovsky Jeremy Chien Francesca Di Sole Galina Gabrielly Kyoung-Youn Han Scott X. Atwood William D. Bradley King Tung Chin Eileen T. Dimalanta Ana Paula Gadelha Sung Sik Han Stephen Richard Au Andrea H. Brand Matthias Chiquet Wei Ding William Allen Gahl Wendy Knowles Hancock Benoit Auclair Evan Mark Braunstein Ajay B. Chitnis Zhijie Ding Leontine Lorenza Galante Meredith L. Hanel Nina M. Aula Gerda E. Breitwieser Yi-Jen Chiu Ndeye Khady Diop Shawn A. Galdeen Helen G. Hansma Christopher M. Austin Ian M. Brennan Hyeseong Cho Kevin Ditolvo Thierry C. Galvez Kazutsune Harada Hibah O. Awwad David Breslauer Somi Kim Cho Gilles Divita Qiong Gan Masaru Harada Bilal Azakir Vania Broccoli Sun Joo Choi William E. Doering Meghal Gandhi Jessica R. Harrell Olga Azarenko Daniel R. Brown Thanat Chookajorn Katherine R. Doherty Haixiao Gao Yosuke Hashimoto Ishara F. Azmi Eric M. Brown Jung Nyeo Chun Toshio Doi Qingshen Gao Emily M. Hatch Tonie Luise Baars Heather Megan Brown Jean-Ju L. Chung Gang Dong Ana F. Garcia Courtney G. Havens Vladimir Babakov John W. Brown Jared Markam Churko Yimin Dong Elizabeth Garcia Kyle A. Havens Zsolt Bacso Anja C. Bruehl Audrey Claing Emmanuelle Donier Kristin C. Garcia Aki Hayashi Xiaoyang Bai Christina D. Buchanan Katherine Clark Luke E. Dow Melissa Carmen Garcia Ikuko Hayashi Daniel J. Bailey Andrea Buchstaller Pamela Agatha-Georgia Haining Du Fiona Claire Gardiner Kazutaka Hayashida Robert Edward Bakin Yadunanda K. Budigi Clarke Tina Xiaogu Du Jesse C. Gatlin Melissa Annette Hayden Malina A. Bakowski Christoph J. Burckhardt Anne-Kathrin Classen Sophie Dumont Nancy S. Gavert Suqin He Colleen L. Ball Jemima J. Burden Christoph S. Clemen Sarah Dunn Scott R. Gehler Wen-Jun He Anna Chrisman Ballew Jason A. Burgess Christian A. Clement Emilie Dupre Martina G. Gentzsch Xiangwei He Kenneth Ban Allison K. Busch Brian Coblitz Omer Dushek Sharon Gerecht-Nir Dorian T. Henderson Gregory Bannish Cherie L. Butts David Coffey Mahasweta D. Dutt Jennifer Lynn Gerton Jacqueline A. Hendries Parmil K. Bansal Matthew T. Cabeen Michael S. Cohen Olivier Duverger Rory König Geyer Carmel E. Hensey Natalya N. Baranova Rodrigo Cabrera Richard N. Cohen Arnaud F. Echard Haifa P. Ghandour Won Do Heo Sonja Karin Bareiss Linda A. Cahill Sarah Cohen Rachael E. Eckert Larisa Gheber Shane P. Herbert Irene Barinaga-Rementeria Dawen Cai Jessica M. Colon-Franco Mark L. Edwards Kaustabh Ghosh Sandra Hernandez Ramirez Troy D. Camarata Cosimo Commisso Rachid M. El Bejjani Pradipta Ghosh Heather Anne Hess Robert B. Barlow Alp Can Salvatore J. Coniglio Jack Elands Patrick Giguere Misao E.L. Higashi Daniel Hull Barnett Veronica A. Canadien Emilee Colleen Connors Nesrine El-Bizri Michael L. Ginger Wendy Maile Higashide Duarte C. Barral Canhong Cao Suzanne D. Conzen Maria Christina Elias Paul Gissen Yoshinori Hiraoka Justine V. Barry Chunzhang Cao Atlanta G. Cook Carrie Ann Elzie Shannon S. Glaser Masafumi Hirono Elizabeth P. Bartley Anne Elizabeth Carlson Daniel Coombs Edward Wai Young Eng Kevin A. Glenn Janet M. Hock Kristen Marie Bartoli Hector Y. Caro-Gonzalez Emily M. Coonrod Holly C. Epple Kristina M. Godek Jason Hodin Francesca Bartolini Anne E. Carpenter Colin A. Cooper Patrick Erbacher Eva Marie Goellner Jan B. Hoek Rene Bartz Jesús Casas Rodríguez Manning J. Correia Alejandro A. Erices Jacky Goetz Maarten Hoek Amanda E. Bass Michael Albert Casha Rosaria Costa Muneer A. Esmail Avanti S. Gokhale Jeremy Damon Hoff Ricardo J.C. Nunes Bastos Aurelia Cassany Mathieu Cotton Christopher William Espelin Elysa Brooke Goldberg Brenton D. Hoffman Roshni Basu Alesha B. Castillo David W. Courtman Eric J. Espinosa Ken N. Goldie Oliver Hofnagel

46 ASCB NEWSLETTER JANUARY 2006 David E. Hokanson Ravi Kandasamy Charles-Antoine Wenxiao Lu Matthew W. McNatt Norbert Muecke Julie E. Hollien Makoto Kaneda Lamontagne-Carpin Eliana Pires Lucas Jason A. Mears Kathrin Muentener William B. Holmes Xiao Kang William L’Amoreaux Anna Lisa Lucido Nida Meednu Khawaja A. Mujeeb Catarina Homem Natalia A. Kaniuk Wendy Lan Alexandra Vitko Lucs Karim Mekhail Monalisa Mukherjea Amy Saw-Tin Hong Lukas C. Kapitein Yves D. Landry Hilary F. Luderer Caroline Valentine Meloty- Shaeri Mukherjee Jeff W. Hook Iakowos Karakesisoglou Stephanie D. Lane Njuguna Kara Beth Lukasiewicz Kapella Svetlana A. Mukhina Osamu Hori Ryan L. Karcher Ellen M. Langer Sarah Luke-Glaser Andrew C. Melton Saikat Mukhopadhyay Jonathan Michael Horowitz Karen E. Kasza Caroline E. Laplante Nicole Lund Rima Mendonsa Somshuvra Mukhopadhyay Rosy Hosking Kosaku Kato Paul D. Larsen Troy C. Lund Gustavo C. Menezes Srinivas R. Mullapudi Ming-Chin Hou Fumoto Katsumi Hakeem O. Lawal Elaine Patricia Lunsford Shekar Menon Ji Young Mun Fiona Jillian Houghton Hiroaki Kawashima Zoltan Emery Lazanyi Carine R. Lussier David C. Merz Vidhya Munnamalai Mary Howe Katherine Ann Kedrowitz Michelle Denise Lazarus Michael P. Lynch Gulistan Mese Hitoshi Murata Roxanne Patreace Howell Thomas J. Keller Isabelle Le Blanc Chongze Ma Stephanie K. Mewborn Silvia Muro Ventzi A. Hristova Salla Elina Keskitalo Craig A. Leach Peisong Ma Kristin E. Michael Jane Elizabeth Murphy Andy T. Hsieh Elaine M. Khan Jennie B. Leach Samar W. Maalouf Angel P. Miera Madeline A. Murphy Chang-Deng Hu Abha Khandelwal Chih-Ying Lee Valentin Magidson Kirstin J. Milks Sivaram V S Mylavarapu Ling-Yueh Hu Paul A. Khavari Hyunsook Lee Susanne Maier Dana L. Miller Saburo Nagata Mickey C. Hu Arlinet V. Kierbel James T. Lee Jean-Christian Maillet Eric D. Miller Satoko Nakada Shaw (Xiao) Tang Hu Areum Kim Kyung Jin Lee Sankar Maiti Julie J. Miller Hideaki Nakamura Kai-Ling Huang Chan Woo Kim Linda Lee Sankar N. Maity Stephanie A. Miller Shun Nakamura Pei-Hsin Huang Dae-Ran Kim Mike Lee Amitabha Majumdar Steven C. Miller Naoki Nakayama Ping Huang Dae-young Kim Ping-Chin Lee Helen P. Makarenkova Kyoeng Woo Min Yuji Nakayama Pinwei Huang Dong-Hwan Kim Sang-Hoon Lee Hector M. Maldonado Naoki Mine Roland M. Nardone Shile Huang Hong-Hee Kim Seungbok Lee Marina Alexandra Malikova Miguel Miron Mendoza Hoorig Nassanian Yinyi Huang Jae Hwan Kim Seungmin Lee Alvin M. Malkinson Shalini Mitra Paramasivam Natarajan Zhen Huang Jinoh Kim Suho Lee Emily K. Malmberg Daisuke Mizuno Sangeeta Nath Sebastien Huet Jung A. Kim Sung Haeng Lee Shu Mao Emi Mizuno Svetlana Nazarenko Patrick Orson Humbert Jung Kyung Kim Tae Hoon Lee Yong Mao Craig A. Mizzen Taku Nedachi Mien-Chie Hung Jung-Mi Kim Kay K. Lee-Fruman Ron R. Marchelletta Toshifumi Mogami Belinda Sonia Nedjai Geoffrey Charles Hunt Mi-Lyang Kim Sally J. Leevers Deborah Maret Anand Mohan Cheryl Neilson Marguerite E. Hunt Minsoo Kim Jennifer L. Leight Owen J. Marshall Alexandra G. Montalvo Lene N. Nejsum Ginny Graham Hutchins Sujeong Kim Colleen R.M. Lemmon Rosie K. Martin Sun-Young Moonlee Elisa M. Nevalainen Lara D. Hutson Su-jin Kim Jan Heiko Lenz Anne-Marie Marzesco Caronda J. Moore Karen Ann Newell Kevin J. Hybiske Sunhong Kim Tzeng-Horng Leu Alexandre V. Matov Daniel P. Moore Erin D. Newman-Smith Miki Ii Lorraine M. King Ilya Levental Hidetada Matsuoka William James Moore Khoa T.D. Nguyen Tal Ilani Megan C. King Stephanie K. Levi Ken Matsuoka Felipe Mora-Bermúdez Mai-Anh Thuy Nguyen Hiroshi Imai Andrea Stewart Kirby Lindsay Kyle Lewellyn Chris P. Mattison Alberto S. Moraes MT Audrey Nguyen Lisa M. Imboden Elizabeth Ann Kirk Christina Carol Lewis Rosalie Maurisse Francisco R. Morales Tu Nguyen-Ngoc Julie Goeun In Adam Edward Kisailus Laura Jane Lewis-Tufﬁn Kapil Mayawala Claire Anne Moran Thomas Q. Nhan Takanari Inoue Katsumi Kitagawa Julieta P. Leyt Gaetan Mayer Carl Benton Moree Susan Melanie Nicholls Pablo M. Irusta Toshio Kitazawa Chun-Chun Li Lisa K. Mayor Ole V. Mortensen Zhongzhen Nie Hisamitsu Ishihara Balaji N. Kithiganahalli Chunying Li Joseph H. McCarty Eva Mortier Mark G. Nielsen Yasuhiro Ishihara Khameeka Nicole Kitt Fang Li Anne Knowlton McCullough Pangkong Moua Akiko Niibori Yoshihiro Ito Juha T. Klefstrom Jonathan J. Li Joseph S. McGonigle Keesla E. Moulton Yusuke Niino Akihiro Iwahashi Lawrence A. Klobutcher Lei Li Rebecca McLennan Jose V. Moyano Rick William Nipper Marcin P. Iwanicki Vitaly Kochin Ming Li Lahoucine Izem Mohamed Kodiha Nianzhen Li Nabila Jabrane-Ferrat Lauren Elizabeth Kokai Ning Li Graham Dillon Jack Juergen F. Kolb Xiaodong Li James W. Jacobberger Helen D. Kollias Xinying Li Julie A. Jadlowiec Olena Kolotushkina Xuehui Li Sarvesh Jajoo Masayuki Komada Xuezhi Li Jennifer Susan Jamieson Vangelis Kondylis Yang Li Kevin A. Janes In Deok Kong Ying Li Experience the first slide-based Hyo Sang Jang Katarzyna Konior Xuehai Liang High Content Analysis tool Florence Janody Ja Seok Koo Yun Liang Ralph Jans Seunghyi Kook Yi-Hua Liao for both adherent and non-adherent Matthias Karl Jansen Greg Koontz Tim Christian Lienau individual living cells: Kent Eric Jardemark Kelly K. Kopp James In Soo Lim Paul J. Jasper Eric Dean Koppelman Precious J. Lim The Optical Fanny Jaulin Farida V. Korobova Roderick Y.H. Lim Louise Marie Jawerth Steven Todd Kosak Chih-Chien Lin ™ David John Jay Atanas V. Koulov Chiou-Feng Lin LiveCell Array Liam Joseph Jeffers Taijun Kouno Daisy Lin John R. Jefferson Olga Kovalenko Paulo J.C. Lin Microscope Slide Format Abbie M. Jensen Sunita Gupta Kramer Qiong Lin for simultaneous HCA of Grant Jay Jensen Laurent Kreplak Steve T. Lin Hyesung Jeon Kannan Krishnamurthy Wendy W. Lin thousands of cells Heetae Jeong Anna M. Krzywicka-Racka Wen-Jie Lin Lin Ji Ashwini S. Kucknoor Yuan Lin Jing Jiang Mitsuhiro Kudo Cory R. Lindsay Keni Jiang Dmitri S. Kudryashov Han Liu Xiuju Jiang Hao Kueh Han-Ching Liu Taiguang Jin Anu Marika Kukkonen Qian Liu Martin Jinek B. N. Kumar Yan Liu Corinne M. John Sudha Kumari Yuan Liu • Compatible with all standard Inneke M. Johnson Anup Kumer Kundu Zhe Liu microscopes Jill L. Johnson Ruprecht A. Kuner Ching-Hsiung Frederick Lo • Easy to use Martha Browning Johnson Yasuhiro Kurasawa Hui-Wen Lo • Minimal sample size + reagent volume Rohan Abraham Joseph Robin KurFurst Angelia D. Lockett • Each cell has its designated address Bret L. Judson Akira Kurisaki Muhammad A. Lodhi • Study heterogeneous populations of Youngsoo Jun Eric Lacazette Dinah Loerke Nadja Jung Yatish Lad Ann Logan primary cells Yeon Joo Jung Yiu-Kay Lai Mustafa F. Lokhandwala • MetaMorph® Imaging Software Jeannette Justesen Fara Lakhani Jadranka Loncarek Applications for enhanced analysis Gregory Lee Kabachinski Premkumar Lakshmanane Veronica Lopez Risto M. A. Kajanne Carla Lalande Yasmin Lotﬁ Also available – Saori Kakehi David P. LaLonde Dawn A. Lowe Optical LiveCell Assay Kits – Apoptosis, Cell Surface Markers Manjula Kalia Tina Iun San Lam Gordon Lu www.molecular-cytomics.com Makoto Kamei Teartse Tim Lambers Lei Lu © 2005 Molecular Cytomics Inc. 1-800-660-6123 Maryam Kamkar Marilyn L. G. Lamm Pengfei Lu LiveCell is a licensed trademark of Molecular Cytomics Ho Man Kan Jan Lammerding Wanli Lu

JANUARY 2006 ASCB NEWSLETTER 47 Wei Niu Rossanna C. Pezo Madalina Rujoi Syrus R. Soltaninassab Rajivkumar J. Vaidya Ting Xie Ching-Ni Njauw Sandra Pfister Jennifer Marie Rutkowsky Deena V. Soni Asta Valanciute Xiaoling Xiong Daisuke No Pallavi Phartiyal Sean Patrick Ryan Aman Sood Dustin S. Vale-Cruz Chang Xu Marissa E. Nolan Katrin Philippar Hisataka Sabe Celeste Siochi/S Soriano Megan T. Valentine Jin Xue Mark Nolden Andrew John Phillips Katharine L. Sackton Julian Sosnik Manojkumar Valiyaveettil Sivaramakrishna Yadavalli Brad J. Nolen James Ashby Pickett Witchuda Saengsawang Dan F. Spandau Pascal Vallotton Akiko Yamada Joshua John Nordberg Jan Pielage Naoyuki Sakai Nathalie Spassky Diana L. Van De Hoef Takenori Yamamoto Pontus Bill Nordenfelt David M. Pier Akira Sakakibara Christoph Spiess Jasper Van Der Gucht Hitomi Akutsu Yamauchi Kristi Lynn Norris Monique S. Pierre Tomoyo Sakata Susan C. Spiller Johannes J. Van Der Want Raghunatha R. Yammani John T. Norton Cecile Marie Pinaudeau Shinji Sakaushi Cynthia C. Sprenger Peter B. Vander Horn Helen Hoi Ning Yan Ryan M. Nottingham Stuart M. Pitson Takashi Sakurai Tim W. Sproul Asta Sinikka Varis Chung S. Yang Roberta B. Nowak Sabine Pokutta Eduardo Perez Salazar R. Michael Sramkoski Hanne Varmark Ge Yang Shun-ya Nunokawa Joseph R. Pomerening Anna-Leena Salmela Carly St Germain Lavanya Vasudevan Hailing Yang Caitlin E. O’Brien Lisa A. Postow Azadeh Samadani Pascal St Pierre Jessica Leslie Verburg Jianguo Yang Lori Lynn O’Brien Jeroen Pouwels Joshua M. Sante Ewa K. Stachowiak P. Thomas Vernier Jiefei Yang Kristen M.S. O’Connell Elaine A. Powers Virginie S. Santilman Angelike Stathopoulos Thuha Nora Vinh Lin Q. Yang Andrea Jean Oestreich Marianne K. Poxleitner Suparna Sanyal Jeffrey H. Stear Philip Vitorino Ling Yang Maiko Ogata Yogikala Vasudeva Prabhu Helen Sarantis Stephanie A. Stehman Pornpun Vivithanaporn Ning Yang Kiyoko Ogawa-Goto Louise Prakash Oli Sarkar Anna Karolina Stephan Nicole E. Vlahovich Ruey-Bing Yang Peter O’Hare Satya Prakash Souvik Sarkar Ruth Anne Stetler Luiz Eduardo Cabral Von Yidai Yang Ryosuke L. Ohniwa William Frederic Pratt Bhaskarjyoti Sarmah Jane C. Stinchcombe Dannecker Ying Chen Yang Takashi Ohyama Ken E. Prehoda Noriaki Sasai Julie Stirling Michelle Valentina Wagner Zhiwei Yang Voytek S. Okreglak Virginia Baker Probin Laura A. Satkamp David L. Stokes Marisa Judith Wainszelbaum Chia-Hui Yeh Athenia Lequan Oldham Jasmina Profirovic Takehiro Sato Agnieszka Stokowski Adam Alexander Wall BhargavaKrishna Yekkala James Arthur Olzmann Derek C. Prosser Pamela J. Savage Timothy R. Stowe Logan A. Walsh Jordan Tyler Yelinek Evgeny A. Onishchenko Anetta Ptasinska Thomas E. Schaus Sten Strunze Thomas Walz Clare E. Yellowley Maria Luisa Oppizzi Xu Pu John Andrew Schmidt Jason K. Stumpff Xiaohu Wan Kexi Yi Shane W. Oram Megan J. Puckelwartz Rebecca Leigh Schmidt Amy K. Sturycz Chao-Wen Wang Yang-In Yim Alana M. O’Reilly Lee Pullan Jean-Francois Schmouth Dmitry Suchkov Chung-Ju Rachel Wang Shanghua Yin Owe J. Orwar Pawan Puri Michael Schnoor Matthew K. Summers Guanghu Wang Kyoko Yokomori Mayuko Osada-Oka Andrew J. Putnam Barbara Schroeder Fang-Chun Sun Hongmin Wang Hiro Yonekawa Kyle D. Osborne Ihtishaam H. Qazi Joyce Ann Schroeder Liping Sun Jie Yi Wang Seong Keun Yoo Mitsunori Ota Zu-he Qi Graham B.I. Scott Sean Sun Jinrong Wang Sung Ok Yoon Christian E. Overgaard Yi Qian Damon Charles Scoville Xinghui Sun Jiz-Yuh Wang Takeshi Yoshimura Katherine Anne Owen Liang Qiang Aristeo Aris Segura Jinfeng Suo Li-Wen C. Wang Brian A. Young John A. Ozolek Jun Qin Seema Sehrawat Alexandra Surcel Ningning Wang Bryan E. Youree Ville O. Paavilainen Baoxi Qu Akiko Seki Benjamin Michael Sutter Qian Wang Chun-ying Yu Eunju Pack-Chung Leonie M. Quinn Paul R. Selvin Toshiharu Suzuki Shujie Wang Soon-Kyu Yun Lesley J. Page Peter B. Rahl Arunima Sengupta Maria Sverdlov Ting Wang Ken K.L. Yung Thomas M. Pagliaruli Emily K. Rainey Rho H. Seong Hideaki Takata Xinhua Wang Adam J. Zahand Chi Won Pak Thejani E. Rajapaksa Benjamin R. Sessions Joy Nicole Talbot Zhaohui Wang Asgar Zaheer Kirsi Inkeri Pakkanen Radhan Ramadass Lisa Michelle Sevilla Dawn A. Tamarkin Heather Hilary Ward Homeira Zahiri Hildur Palsdottir Edward Ramos Catherine M. Shachaf Yasushi Tamura Nancy E. Ward Sofia V. Zaichick Eirikur Palsson Maria E. Ramos-Nino Julia Shackelford Tarvinder K. Taneja Fiona J. Warner Mark Zajac Ewa Paluch Claudine Rancourt Joshua W. Shaevitz Xiaoyu Tang Katrina B. Washburn Liudmila Zakharova Yonghua Pan Aparna C. Ranganathan Sasha H. Shafikhani Yitai Tang Shinya Watanabe Kseniya Zakharyevich Sanjay C. Panchal Maija Kaarina Rantanen Kavita Shah Zhaohua Irene Tang Tomonobu Watanabe Anna J. Zandy Marcelo Jorge Pando U. S. Rao Sameer B. Shah Naoki Tanimizu Barbara D. Wawro Laura P. Zanello Sophie Pang K. Rathinasamy Sze Wan Shan Rocio Tapia Benjamin P. Weaver John K. Zehmer Porntula Panorchan Claude Ratthe Yueting Shang Agne Taraseviciute Susanna H. Weerth Alex Zelter Feroz R. Papa Arpita Ray Irina M. Shapiro Nicolas Taulet Bih-Rong Wei Fan Zhang Iraklis Papageorgiou Colin Reardon Shalini Sharma J. Philip Taylor Ho-Chun Wei Jianliang Zhang Sangram Subhash Parelkar David A. Recinos Vandana M. Sharma Julie P. Taylor Huijun Wei Jun Zhang Audrey Parent Elizabeth F. Redente Tom Shemesh Rohan D. Teasdale Douglas B. Weibel Li Zhang Bum-Chan Park Amber Nicole Reed Hao-Wei Shen Rita O. Teodoro Astrid Weins Sheng Zhang Han Jeong Park Mia D. Reed Yongquan Shen Laura J. Terry Georg Weitzer Siyi Zhang Hee-Sae Park Nathan A. Reed Maryam Shenasa Mathewos Z. Tessema Jennifer V. Welser Vivian Qingqing Zhang Hee-won Park Tanya A. Rege Don C. Sheppard Anita Annajothi Thambirajah Shu-Fang Wen Wei Zhang Jihye Park Veronika Reiterer Anna Shestakova Sean E. Thatcher Jeffrey L. Werbin Wenzheng Zhang Jong Sung Park Maia Kathleen Renihan Svetlana A. Shestopal Melanie C. Thein Brandi R. Whatley Ying Zhang Sun Yi Park Erin C. Rericha Binhai Shi Clement Thomas Ann P. Wheeler Yongli Zhang Young-Kyu Park Juan F. Reyes Qi Shi Sufi Mary Thomas Matthew A. Wheeler Bin Zhao Jeremy D.K. Parker Khosrow Rezvani Yang Shi Jeffrey M. Thompson Anita Elizabeth Wichmann Xin Zhen Samantha Louise Passey Seung K. Rhee Yuling Shi Kathryn A. Thompson Therese Wiedmer Wei Zheng Jenna N. Passman Danielle N. Ringhoff Jennifer Cynthia Shieh Kristjan L. Thompson Darran J. Wigelsworth Anyu Zhou Vinay Pasupuleti Wanida Rittidach Jonathan M. Shillingford Oliver Thompson David J. Wiley Dan Zhou Snehal B. Patel Francisco Rivero Ai Shima Thorhildur Elva Brooke Blairanne Williams Fuguo Zhou Sian T. Patterson Kevin P. Roarty Katsuya Shimabukuro Thorarinsdottir Courtney M. Williams Shuxia Zhou Sara M. Paulillo Kim L. Roberts Norio Shimamoto Laura J. Thornton Geoffrey S. Williams Yuchen Zhou Adriana Aparecida Paulucci Marnie S. Roberts Arti V. Shinde Geng Tian Justin E. Wilson Zheng Zhou Visnja Pavicic Brian Wilson Robertson Tomoyasu Shinoda Lin Tian Kathleen L. Wilson Zhenqing Zhou Dmitry A. Pavlov Danielle M. Robertson Orian Shaul Shirihai Winston G. Timp Reinhard Windoffer Zhongjun Zhou Sangita C. Pawar Flavia Riso Rocha Viji Shridhar Shigenobu Toda Rockland Luke Wiseman Changjun Zhu Bradley T. Pawlikowski Katherine W. Roche Andrew Shubov Chris B. Todd Tobias Wolfram Jun Julius Zhu Nina Peel Jennifer M. Rodenberg Robert D. Shurina Andrei A. Tokarev Charles W. Wolgemuth Xiaodong Zhu Stephanie Pellegrin Jose Francisco Rodriguez Anita Sil Masoud M. Toloue Cheuk Y. Wong Amy F. Ziober Jun Peng Rene Rodriguez Gonzalez Pascal Silberzan Louis H.T. Tong Joyce Y. Wong Li Zou Xu Peng Carlos Romero Ece Simsek Michinori Toriyama Wan Man Wong Magdalena Zuerner Ying Peng Panteleimon Rompolas Aman K. Singh Jorge Torres Christopher Sinclair Wood Marek Tadeusz Zygmunt Rhiannon R. Penkert Jachinta E. Rooney Pankaj Kumar Singh Junko Toshima Chia-Shan Jenny Wu Naomi L. Pentland Sara E. Rosasco Vijay Prem Singh Ian K. Townley Chieh-Hsi Wu Members Granted Samantha J. Perez-Miller Raphyel O. Rosby Merek Siu Lucas Trerice Chi-Hwa Wu Alex Perieteanu Martin Rosen Nadimpalli Siva Kumar Niraj Trivedi Guangyu Wu Emeritus Status Leticia Peris Krysten M. Ross Senthilkumar Sivagurunathan I-Chun Tsai Jianhong Wu William W. L. Chang Nathalie Perreault Stefano Rossetti Sivaraj Sivaramakrishnan Robert Y. Tsai Jie Wu Joseph Feder Shanda Nicole Perry Daniel Roth Sudhakar Sivasubramaniam Ann-Ping Tsou Karen Wu Robert E. Fellows Gary Anthony Pestano Lise Roth Stephan Urs Sixt Andrey S. Tsvetkov Wei Wu Gordon Gill Marina Petcherskaia Elon C. Roti Roti Lara C. Skwarek Jeffrey J. Tung Wen-Guey Wu Peter Hepler Elizabeth Margaret Peter- Aurelien Roux Adam C. Smith Jeffery Lewis Twiss Yuehan Wu James D. Jamieson Ross Kyle J. Roux Andrew Leslie Smith Salit Tzaban Eric S. Wunderlich Joseph Kinkade Iver Petersen Regina K. Rowe Geoffrey L. Smith Pradeep D. Uchil Jessica Paige Wyles Ramon Lim Snezana Petrovic Isabelle Royal Chi K. So Takashi Ueno Wa Xian Andrej Rotter ■ Richard B. Rubin Jacqueline Ariel Sobota Ahmad R. Utomo Lele Xie

48 ASCB NEWSLETTER JANUARY 2006

INCYTES from MBC January, Vol. 17, No. 1

Molecular Interaction Maps of Bioregulatory Networks: A General Rubric for Systems Biology Kurt W. Kohn, Mirit I. Aladjaem, John W. Weinstein, and Yves Pommier

As information regarding the protein interactions, posttranslational modifications, regulatory kinases, and GTPases associated with bioregulatory networks expands, their complexity becomes too great to be displayed by simple linear notation or understood by simple intuition. Thus, a new standard for bioregulatory network diagrams using common graphical notations is urgently needed to serve cell and developmental biologists in the same way as circuit diagrams serve electrical engineers. Here the authors describe a graphical notation for molecular interaction maps (MIMs), including protein interactions, posttranslational modifications, ligand binding, translocation, transcription, etc., which, from a biologist’s perspective, is both intuitive and versatile. Generating initial “heuristic” MIMs (i.e., those in which all known interactions and their consequences are diagrammed) requires deep and critical thinking about the structure and function of a specific network. Once generated, MIMs can be annotated and made interactive (http://discover.nci.nih.gov/mim) and can serve as the basis for more “explicit” MIMs that are amenable to computer modeling and simulation.

The CLIP-170 Homologue Bik1p Promotes the Phosphorylation and Asymmetric Localization of Kar9p Jeffrey K. Moore, Sonia D’Silva, and Rita K. Miller

Accurate positioning of the mitotic spindle is critical for cell division in all eukaryotes. In the budding yeast Saccharomyces cerevisiae, the spindle pole bodies (SPBs) are embedded in the nuclear envelope and their accurate positioning requires two sequential microtubule (MT)-dependent processes. The ﬁrst uses cytoplasmic MTs (cMTs) and actin cables to direct the nucleus to the bud neck and to orient the SPBs along the mother–bud axis. The MT-to-actin linker, Kar9p, is asymmetrically localized to the SPB destined for translocation into the bud and plays a critical role in this process. Kar9p is transported to the plus ends of cMTs where it interacts with Myo2p, attaching them to the bud cortex. The Kar9p- containing SPB is then drawn into the bud by dynein, which is targeted to the plus ends of cMTs by the CLIP170 homologue Bik1p. The authors have discovered that Bik1p also interacts with Kar9p and has a second, unrelated function of promoting Kar9p phosphorylation, thereby ensuring its asymmetric localization to one SPB and associated cMTs.

Mitochondrial AKAP121 Links cAMP and Src Signalling to Oxidative Metabolism Alessandra Livigni, Antonella Scorziello, Savina Agnese, Annagrazia Adornetto, Annalisa Calucci, Corrado Garbi, Imma Castaldo, Lucio Annunziato, Enrico V. Avvedimento, and Antonio Feliciello External signals are transmitted intracellularly by protein kinase signaling cascades. A-kinase anchor proteins (AKAPs) are a family of proteins that target kinases to distal cellular substrates, thereby enhancing the efficiency of signal propagation. Here it is shown that AKAP121, which binds protein kinase A (PKA) and the protein tyrosine phosphatase PTPD1, forms a signaling complex that also includes src kinase. In response to stimuli, AKAP121 targets these kinases to the mitochondria where they phosphorylate specific mitochondrial target proteins. The authors used co-expression, dominant-negative mutants, and siRNA approaches to establish that PKA- and src-dependent changes in mitochondrial membrane potential and ATP synthesis are enhanced by AKAP121. Thus, AKAP121 functions as a nodal point to integrate cAMP-dependent PKA activity with src-dependent tyrosine phosphorylation and efficiently adapt mitochondrial metabolism to changes in cell physiology.

Conserved Pre-fusion Protein Assembly in Regulated Exocytosis Colin Rickman, José L Jiménez, Margaret E. Graham, Deborah A. Archer, Mikhail Soloviev, Robert D. Burgoyne, and Bazbek Davletov

Regulated secretion is mediated by ternary complex formation between the plasma membrane t-SNARES, syntaxin1 and SNAP-25, and the secretory vesicle-associated v-SNARE, synaptobrevin, and regulated by the Ca2+-sensor synaptotagmin (SYT). The structural nature of the pre- fusion complex that docks secretory vesicles to the plasma membrane and the mechanism of rapid calcium-triggered fusion remain unknown. Guided by evolutionary conservation, the authors identiﬁed residues that demark the binding interface between SNAP-25 and SYT. Computer- based algorithms were then used to dock the known atomic structures of the C2B domain of SYT with the ternary t-SNARE/v-SNARE complex. A model is presented in which the C2B domain of SYT binds perpendicular to the helices of a binary SNAP-25/syntaxin1 t-SNARE assembly. This pre-fusion complex would provide a precisely organized “tethering” scaffold that limits t-SNARE diffusion, positions them for rapid engagement with synaptobrevin, and positions the C2 domains of SYT for optimal Ca2+ responsiveness. ■

50 ASCB NEWSLETTER JANUARY 2006 ADVERTISEMENT Microarray Resources

GeneSifter Data Center Built for biologists, by biologists, the Access and analyze diverse sets of GeneSifter® web-based gene expression microarray data with the GeneSifter analysis system microarray data analysis combines an easy-to-use “I find GeneSifter to system, using the interface with powerful be the friendliest GeneSifter Data Center. data management tools Analysis summaries and to quickly load data files and one of the most step-by-step tutorials are from every array valuable personal provided for each dataset, Step-by-step tutorials walk platform (CodeLink®, analytical tools I've making it an excellent through common analyses Affymetrix®, Illumina®, resource for developing Agilent® and custom used to date.” microarray data analysis arrays). Once loaded, Grover C. Bagby, M.D. skills. Use the Data Center GeneSifter integrates OHSU Cancer Center to better understand advanced statistical microarray data analysis algorithms, robust ontology and pathway or to explore the data for interesting reports, and the most current gene connections and expression patterns. annotations to help bench researchers move Available datasets include: quickly from data to discovery. Plus, as a �� FVB heart development time series Search by gene function web-based system, GeneSifter makes it easy �� Microarray analysis of CD40-mediated to share findings in real time with colleagues gene expression in Ramos cells and collaborators across the hall and across �� Transcriptome analysis of apoE -/- the globe. mouse aortas In addition to statistics and reporting, �� TNF-mediated gene expression in GeneSifter provides full scientific support. HUVEC Led by PhD-level biologists, the GeneSifter �� Drosophila innate immune response Scientific Staff provides support on a time series range of levels from experimental design �� Transcriptome analysis of orofacial to grant submission to data publication. development in mouse embryo Gene Ontology Reports identify To learn more, visit www.GeneSifter.net �� Astrocyte response to beta amyloid significant pathways and �� Huntington's disease and combination molecular functions The Seven Keys drug therapy Maximize the potential of your microarray �� Sex-related differences in gene experiments with ”The Seven Keys To expression in salivary glands Successful Microarray Data Analysis,” a free �� Chronic contusion spinal cord injury microarray training website providing an �� Transcriptome analysis of colon cancer overview of and introduction to the progression microarray data analysis process. The For free access to these datasets and others, Seven Keys site, MicroarraySuccess.Org, visit www.GeneSifter.net/DC has already helped thousands of researchers gain a better understanding of basic Webinars Examine gene expression profiles microarray data analysis. Monthly webinars presented by the The Seven Keys are: GeneSifter Scientific Staff present alternative 1) Experiment Design analyses of recently published microarray 2) Platform Selection studies. This series extends published 3) Data Management results and emphasizes how experimental 4) System Access design affects the analysis process. 5) Differential Expression N. Eric Olson, PhD, Genesifter Chief 6) Biological Significance Scientific Officer, will present the next 7) Data Publication webinar, “Transcriptome analysis of adult Intuitive web interface to View the Seven Keys and download the male germ cell tumors,” on February 7. R statistics case study “Identification of cell cycle genes Email [email protected] to learn more. To www.GeneSifter.net regulated during erythroid differentiation,” register for these webinars at no cost, visit at www.MicroarraySuccess.Org www.GeneSifter.net/webinar 1-877-WEB-GENE

ADVERTISEMENT GRANTS & OPPORTUNITIES

BWF/HHMI Lab Management Guide. Making the Right Moves: A Practical Guide to Scientiﬁ c Management for Postdocs and New Faculty is available at www.hhmi.org/labmanagement.

The Human Frontier Science Program. Funding opportunities for team research projects in the basic life sciences. Deadline for letter of intent is March 30; potential applicants must pre-register by March 20. www.hfsp.org.

NIH Virtual Career Center. The NIH Ofﬁ ce of Education offers resources for exploring employment options and career development opportunities in health sciences. See www.training.nih.gov/careers/careercenter/index.html.

NIAID Biodefense Fellowships. The NIH National Institute of Allergy and Infectious Diseases solicits applications from biodefense training and development researchers of prevention, detection, diagnosis and treatment of diseases caused by potential bioterrorism agents. Grants, fellowships and career development awards. See www.niaid.nih. gov/biodefense/research/funding.htm.

NIH Re-entry Program. The NIH and Ofﬁ ce of Research on Women’s Health announce a continuing program for faculty who have taken time out for family responsibilities. See http://grants.nih.gov/grants/guide/pa-ﬁ les/PA-04-126.html.

NIH Grants. ■ Large-Scale Collaborative Project Awards, see http://grants2.nih.gov/grants/guide/pa-fi les/PAR-04-128.html. Dead- lines: September 20, 2006, and June 21, 2007. ■ Predoctoral Research Training in Biostatistics, see http://grants2.nih.gov/grants/guide/pa-fi les/PAR-04-132.html. Deadline: October 12, 2007. ■ Tools for Genetic and Genomic Studies in Emerging Model Organisms, see http://grants2.nih.gov/grants/guide/pa- fi les/PA-04-135.html. Deadline: November 2, 2007. ■ National Technology Centers for Networks and Pathways, see http://grants2.nih.gov/grants/guide/rfa-fi les/RFA-RM-04- 019.html. Deadline is February 22. ■

Free Chair, Department of Cancer Biology Career Advice Lerner Research Institute Publications The Cleveland Clinic Foundation

The Cleveland Clinic Foundation is seeking a Chair for the Department of Cancer Biology, which occupies ~30,000 sq. ft. in the Lerner Research Institute. An endowed chair accompanies this position. The department currently consists of 12 faculty with well-funded research programs in the areas of signal transduction and gene expression, apoptosis, cytokine action, and cell cycle regulation. The ideal applicant will have an outstanding national reputation in an area that complements the strengths of the department. The Chair of Cancer Biology will also hold appointment as Associate Director for Basic Science of the Cleveland Clinic Taussig

Cancer Center, and will have a cross appointment in the matrix format Life Science Research and Teaching: of the NCI-designated Case Comprehensive Cancer Center. Strategies for a Successful Job Hunt

The Chair will be provided with generous start-up support and recruitment packages for 4 to 5 new faculty. The Lerner Research Institute,

with over 130 independent investigators in 10 departments and an an- Career Advice for Life Scientists II nual budget of >$110 million, has a commitment to excellence in ba- Career Advice for Life Scientists I sic and applied biomedical research.

A curriculum vitae and letter of interest should be sent to Paul E. DiCorleto, Ph.D., Search Committee for the Chair of Cancer Biology, Cleveland Clinic Lerner Research Institute–NB21, 9500 Euclid Avenue, Pick up your copies at the ASCB Annual Meeting or Cleveland OH 44195; www.lerner.ccf.org/cancerbio/; [email protected]. order your copies through the ASCB Online Store The Cleveland Clinic Foundation is an Equal Opportunity Employer. www.ascb.org

52 ASCB NEWSLETTER JANUARY 2006

NewsletterCoverFinal 9/29/05 5:57 PM Page 1

SUPPORTING LIFE SCIENCE RESEARCH FOR OVER 35 YEARS

• Ubiquitin Abs • Apoptosis Abs • Signal Transduction Abs • Neuroscience Abs • Epitope & Fusion Protein Abs

> two color westerns > immunohistochemistry > two color in-gel westerns > protein phosphorylation > immunofluorescence

OCKLAND

Phone: 800-656-ROCK Fax: 610-367-7825 Email: [email protected] Website: www.rockland-inc.com MEETINGS Calendar

March 8-10,2006. Bethesda, MD June 5-9. Atlanta, GA Cell Line Identiﬁcation and Authentication lecture/lab American Society for Microbiology General Meeting. course. Sponsored by Foundation for Advanced Education www.asm.org. in the Sciences at the NIH. www.biotrac.com. June 10-22. Vancouver, BC ASCB April 3-7, 2006. Bethesda, MD Eleventh Annual International 12-Day Short Course on 3D Annual Meetings Animal and Human Cell Culture lecture/lab course Microscopy of Living Cells. Applications due March 15. Sponsored by Foundation for Advanced Education in the www.3dcourse.ubc.ca/application.htm. 2006 Sciences at the NIH. www.biotrac.com. San Diego June 24 -26. Vancouver, BC December 9-13 March 15-19. Lake Tahoe, CA Tenth, Post-course Workshop on 3D Image Processing. Third International Conference on Structural Analysis of Applications due March 15. 2007 Supramolecular Assemblies by Hybrid Methods. www.3dcourse.ubc.ca/application.htm. Washington, DC www.burnham.org/hybridmethods2006/. December 1-5 July 13-17. New York, NY April 30-May 4. Barcelona, Spain Second International Symposium on Triglycerides, 2008 European Symposium of the Protein Society. Metabolic Disorders and Cardiovascular Diseases. San Francisco www.proteinsociety.org. www.lorenzinifoundation.org/. December 13-17 May 2-3. Bethesda, MD July 15-18. Boston, MA 2009 Bone Quality: What Is It and Can We Measure It? Stem Cell Niches. ASCB Summer Meeting. www.ascb.org. San Diego www.asbmr.org/bonequality.cfm. December 5-9 July 20-23. Atlanta, GA May 16-17. Bethesda, MD The Cell Biology of HIV-1 and Other Retroviruses. 2010 Cellular Niches Workshop sponsored by NIDDK/NIH/DHHS. ASCB Summer Meeting. www.ascb.org. Washington, DC http://cellularniche.niddk.nih.gov. December 11-15 September 1-5. Muensterschwarzach Abbey, Germany May 23-25. Charlottesville, VA The Wilhelm Bernhard Workshop–19th International 2011 Morphogenesis and Regenerative Medicine Symposium at Workshop on the Cell Nucleus. Denver the University of Virginia. www.zeb.biozentrum.uni-wuerzburg.de/. ■ December 3-7 www.morphogenesis.virginia.edu.

8120 Woodmont Avenue Non-proﬁt Suite 750 Organization Bethesda, MD 20814-2762 US Postage PAID Bethesda, MD Permit No. 356