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Lsibooklett V.25.Indd Bacterial Adaptation & Response Networks http://barn.lsi.ubc.ca [email protected] lsi.ubc.ca barn.lsi.ubc.ca Life Sciences Institute Sciences Life email: web: web: http://barn.lsi.ubc.ca Bacterial Pathogenesis Bacterial Biochemistry Bioinformatics Chemistry Genetics Genomics ecology Microbial physiology Microbial biology Structural • • • • • • • • • Research StrengthsResearch & Facilities The Bacterial Adaptation and Response Networks Research Group Group Research Networks and Response Adaptation Bacterial The the departments of Biochemistry & Molecular from includes members & Immunology and Zoology. Microbiology Biology, and expertise in a individuals with experience comprises group This of disciplines, including: range broad is investigation members linking all of the group thread common The The their environments. to adapt and respond bacteria of how and including soil and the ocean, diverse, studied are environments common are there However, bacteria. pathogenic the human host for these diverse to molecular mechanisms of adaptation and response research common share members group Thus, environments. approaches. the study of one adaptation or from gained Understanding and response Adaptation others. is applicable to network response include: this group to mechanisms of particular interest networks regulatory (1) genetic walls and cell membranes of molecules across (2) transport great t from of these fundamental mechanisms benefi Investigations transfer gene (3) horizontal these fundamental Further, synergy. and infrastructural intellectual making bacteria organisms, in multicellular mechanisms also occur applicable broadly developing for systems experimental excellent knowledge. Bacterial Adaptation Adaptation Bacterial ... (BARN) Networks & Response Zoology (MSc, PhD) Zoology BioInformatics (MSc, PhD) BioInformatics Graduate Programs Graduate Microbiology & Immunology (MSc, PhD) Microbiology Cell & Developmental Biology (MSc, PhD) & Developmental Cell Biochemistry & Molecular Biology (MSc, PhD) ...how bacteria adapt, respond to their environments, & cause disease. BARN Researchers: Recent Publications Fogg PC, Hynes AP, Digby E, Lang AS, Beatty JT. (2011). J. Thomas Beatty: virus-like gene transfer agents; Characterization of a newly discovered Mu-like bacteriophage, photosynthetic pigment-protein complexes RcapMu, in Rhodobacter capsulatus strain SB1003. Virology 421:211-221 Sean Crowe: geomicrobiology Murakami T, Burian J, Yanai K, Bibb MJ, Thompson CJ. (2011). A Franck Duong: essential process of protein transport system for the targeted amplifi cation of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor. Lindsay Eltis: bacterial degradation of aromatic compounds and PNAS 108:16020-16025. steroids, including lignin & cholesterol Roberts JN, Singh R, Grigg JC, Murphy ME, Bugg TD, Eltis LD. (2011). Characterization of dye-decolorizing peroxidases from Rachel Fernandez: molecular pathogenesis of Bordetella Rhodococcus jostii RHA1. Biochem 50:5108-5119. pertussis: biogenesis and immunomodulatory properties of the outer membrane Lin AE, Krastel K, Hobb RI, Thompson SA, Cvitkovitch DG, Gaynor EC.(2009). Atypical roles for Campylobacter jejuni amino acid Erin Gaynor: molecular pathogenesis of foodborne human ATP binding cassette transporter components PaqP and PaqQ in pathogens bacterial stress tolerance and pathogen-host cell dynamics. Infect & Immun 77:4912-4924 Steven Hallam: microbial systems ecology and functional metagenomic screens Marr N, Novikov A, Hajjar AM, Caroff M, Fernandez RC. (2010). Variability in the lipooligosaccharide structure and endotoxicity George Mackie: the properties of the relevant enzymes and among Bordetella pertussis strains. J Infect Dis 201:1897-1906. RNA chaperones, the functional state of the mRNA and the Garrey SM, Mackie GA. (2011). Roles of the 5’-phosphate sensor secondary or tertiary structure of the RNA substrate determine domain in RNase E. Mol Microbiol 80:1613-1624. its fate Reaves ML, Sinha S, Rabinowitz JD, Kruglyak L, Redfi eld RJ. (2012). William Mohn: ecology of forest soil and gut microbial Absence of detectable arsenate in DNA from arsenate-grown communities; bacterial steroid metabolism GFAJ-1 cells. Science 337: 470-473 Wright JJ, Konwar KM, Hallam SJ. (2012). Microbial ecology of Michael Murphy: mechanism of iron homeostasis in pathogenic expanding oxygen minimum zones. bacteria Nature Reviews Microbiol 10: 381-394. Rosemary Redfi eld: the ability of Haemophilus infl uenzae to take Graduate Studies Admission up DNA from their surroundings UBC Faculty of Graduate Studies establishes common minimum academic requirements. One of the major requirements for LSI John Smit: biotechnology applications using the S-layer of graduate programs is securing a research supervisor. Caulobacter Charles Thompson: regulation of bacterial gene expression Contact associated with tuberculosis Recruitment & Outreach Coordinator [email protected] website: grad.lsi.ubc.ca Grad School @ UBC The University of British Columbia UBC offers over 130 master’s and doctoral UBC is a global centre for research and teaching, consistently ranked among the 40 degree programs in nearly every academic fi eld best universities in the world. Surrounded by the beauty of the Canadian West, UBC embraces bold new ways of thinking that attract exceptional students and faculty. It is a imaginable. place where innovative ideas are nurtured in a gloablly connected research community, Discover more. www.grad.ubc.ca providing unparalleled opportunites to learn, discover and contribute in one’s own way. UBC is a place of mind..
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