Henry Ford Hospital Medical Journal Volume 9 | Number 3 Article 14 9-1961 Clinical Evaluation Of Methyclothiazide, A New Potent Long-acting Oral Diuretic Drug Stephen Podolsky Morton Fuchs Robert Sellor Follow this and additional works at: https://scholarlycommons.henryford.com/hfhmedjournal Part of the Chemicals and Drugs Commons, Life Sciences Commons, Medical Specialties Commons, and the Public Health Commons Recommended Citation Podolsky, Stephen; Fuchs, Morton; and Sellor, Robert (1961) "Clinical Evaluation Of Methyclothiazide, A New Potent Long-acting Oral Diuretic Drug," Henry Ford Hospital Medical Bulletin : Vol. 9 : No. 3 , 440-449. Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol9/iss3/14 This Article is brought to you for free and open access by Henry Ford Health System Scholarly Commons. It has been accepted for inclusion in Henry Ford Hospital Medical Journal by an authorized editor of Henry Ford Health System Scholarly Commons. For more information, please contact
[email protected]. CLINICAL EVALUATION OF METHYCLOTHIAZIDE, A NEW POTENT LONG-ACTING ORAL DIURETIC DRUG STEPHEN PODOLSKY, M.D.'^', MORTON FUCHS, M.D."='* and ROBERT SELLOR, M.D.'-''' The advent of thiazide diuretic drugs has opened a new and effective means of helping the patient with edema. Many potent oral agents have been developed which cause a diuresis of salt and water. The parent compound is chlorthiazide, the pharma cology of which has been described by Ford, Moyer and Spurr.' The drug stimulates sodium and chloride excretion and, to a lesser extent, potassium and bicarbonate excretion. It works both orally and intravenously, but is excreted very rapidly when given I.V.^ The urinary excretion patterns are similar to the mercurial drugs, except for greater potassium excretion.