Patent: US 8,105,569 B2 Aminosensyl™ HC Breakthrough Technology
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Patent: US 8,105,569 B2 AminoSensyl™ HC Breakthrough Technology Eco-Friendly 100% Natural ü Renewable Sources ü Essential Amino Acid ü Quat-Free ü Brassica Alcohol ü Readily Biodegradable ü Green Chemistry High Performance Scientific Innovation ü Conditions ü Amphiphilic and Cationic ü Strengthens Amino Lipid ü Smooths & Defines ü Patented Technology Green Chemistry for Sustainable Innovation in Hair Care Actives Hair Care Opportunities focus on Sustainable Ingredients Global Opportunities Hair Care Europe & Americas Opportunities Hair Care A Year of Innovation in Hair Care, Mintel Report, May 2018 Green Chemistry at INOLEX At INOLEX, innovation is guided by the principles of green chemistry and life cycle thinking. Our goal is to provide ingredients that deliver objective, measurable improvements in performance, consumer preference, AND sustainability. Key strategies: • Effective use of renewable, plant-based feedstocks; pursuit of new bio-based alternatives • Safe, simple chemistry with sophisticated performance • Articulating and minimizing trade-offs to avoid hidden costs/consequences of “natural” Anastas, P. T.; Warner, J. C. Green Chemistry: Theory and Practice, Oxford University Press: New York, 1998, p. 30. Amino Lipids Technology Platform Proprietary Technology Platform for development of tailored and high performance amino lipids with superior environmental and safety profiles Building Blocks of Key Features of INOLEX Amino Lipids: INOLEX Amino Lipids: Amino Acid ü 100% Natural ü Derived from biofermentation ü Non-Quat Cationic Charge ü Contains amine functionality ü Based on Amino Acid ü Provides a natural cationic charge ü Patented Hair Care Actives Fatty Alcohol ü Derived from renewable plant oil ü Contains hydrophobic carbon chain ü Plant oils chosen for desired mixture of carbon chain lengths AminoSensyl™ HC Innovative Technology Design Essential Amino Acid - Valine: ü Derived from biofermentation of sugarcane glucose ü Provides a natural cationic charge for hair substantivity ü Valine occurs naturally on the cuticle of hair Fatty Alcohol - Brassica Alcohol: ü Derived from the Brassica Napus seed oil ü Genus Brassica contains a variety of nutrient rich plants ü Provides an optimized mixture of C18 – C22 carbon chains for conditioning & strengthening performance INCI: Brassica Alcohol (and) Brassicyl Valinate Esylate AminoSensyl™ HC is Eco-Friendly • Developed and manufactured according to the Principles of Green Chemistry • 100% renewable and sustainable raw material feedstocks • Solvent-free manufacturing process • No heavy metal catalysts and moderate reaction temperatures for low energy consumption • Water is the only reaction by-product • Brassicyl Valinate Esylate is readily biodegradable • Non toxic and Non irritating Amino Lipids have Superior Safety and Environmental profiles Cationic Amino Quaternary Amidoamines Lipids Surfactants e.g. e.g. e.g. Brassicyl Valinate Behentrimonium Stearamidopropyl Esylate Chloride Dimethylamine Irritation Potential Increases with decreasing SKIN Non-hazardous IRRITANT to Skin and Eyes alkyl chain length CORROSION REFERENCES Aquatic Toxicity Potentially toxic to fish, Non-hazardous AQUATIC AQUATIC • Safety Assessment of invertebrates, algae TOXICITY TOXICITY Trimoniums as Used In Cosmetics, 2012. • SCCS Opinion on Alkyl (C16, C18, C22) Trimethylammonium Environmental Increases with increasing Chloride, 2009. Readily Readily Persistence alkyl chain length (i.e. ~80% Biodegradable • Ecotoxicological Behavior of Biodegradable Biodegradable some Cationic and Amphoteric increasing hydrophobicity) Surfactants, 2013. • ECHA Substance Information, www.echa.europa.eu, 2019. Petro-chemical Quaternary ammonium derived carbon head groups rely on 100% PETRO PETRO petrochemical-derived NATURAL DERIVED DERIVED carbon High Performance Conditioning for All Hair Types Conditioning & Treatment Markets are Globally Significant ü Hair Conditioning and Hair Treatment markets are significant in all regions ü Hair Treatment market in LATAM is larger than Hair Conditioning market A Year of Innovation in Hair Care, Mintel Report, May 2018 AminoSensyl™ HC Strengthens Hair to Resist Breakage Increased Hair Strength Anti-Breakage Test AminoSensyl HC: Leave-in Conditioner ü Significant reduction in hair breakage from * ↓ 59% both rinse-off and leave-in conditioners ü 54% (2X) increase in hair strength in a rinse-off conditioner application ü 59% (2X) increase in hair strength in a leave-in conditioner application Test Method: • Anti-Breakage Benefits via Repeated Grooming with Custom-Built Automatic Groomer * ↓ 54% • Study performed by TRI/Princeton • European medium brown hair tresses, bleached, 10 replicate tresses • Test Formulation: 8% w/w AminoSensyl HC in water; pH ~4.0 • Rinse-Off Treatment procedure: (1) SLES wash, (2) 3 minute conditioner application, (3) 30s rinse Rinse-off • Leave-In Treatment procedure: (1) SLES wash, (2) Conditioner application Conditioner * p < 0.0001% • Tresses were dried and allowed to equilibrate at 60% RH, 22°C • Dry tresses are groomed for 2,000 cycles. Fibers are collected and assessed every 200 cycles. 0 10 20 30 40 50 Number of Broken Hair Fibers AminoSensylAminoSensyl HCHC ControlUntreated Control AminoSensyl™ HC Creates a Smooth and Defined Appearance 600 Static Build-Up Test Up 500 AminoSensyl™ HC: - 400 ü Hair moisturization in low humidity environment 300 ü Resists static build up from brushing Untreated Control ü Cationic active deposits on damaged hair 200 AminoSensyl HC due to cationic charge and optimized C18-22 Voltage (V) Voltage 100 carbon chain lengths 0 ü Provides a smooth and defined appearance Test Method: -100 • Anti-Static Charge using custom-built device with sensor for real-time measurement • Study performed by TRI/Princeton -200 • European medium brown hair tresses, 8 replicate tresses Decreased Static Build Static Decreased • Treatment procedure: (1) SLES wash, (2) 3 minute conditioner application, (3) 30s rinse Baseline 5 Brush 10 Brush 30s 60s • Tresses were dried and allowed to equilibrate at 30% RH Strokes Strokes Dissipation Dissipation • Test Formulation: 8% w/w AminoSensyl HC in water; pH ~4.0 AminoSensyl™ HC Conditions Damaged Hair 160 Wet Comb Test 140 AminoSensyl™ HC: 120 ü 66% decrease in wet comb force 100 ↓ 66% ü Significant conditioning of damaged hair 80 ü Low use level: 2% w/w active cationic conditioning agent 60 Test Method: Maximum Load (gf)Maximum Load • Measurement of Wet Combing Forces using Instron tensile tester, 40 Study performed by TRI/Princeton • European medium brown hair tresses, bleached; 8 replicate tresses Increased Conditioning Increased • Treatment procedure: (1) SLES wash, (2) 3 minute conditioner application, 20 (3) 30s rinse • Combing experiments performed in the wet state, 6 comb strokes per tress 0 * * p < 0.0001% • Test Formulation: 8% w/w AminoSensyl HC in water; pH ~4.0 UntreatedControl Control AminoSensyl HC Intensive Conditioning Bar Trade Name Ingredient (INCI) %(w/w) 1 AminoSensyl™ HC Brassica Alcohol (and) Brassicyl Valinate Esylate 90.00 A sustainable take on a traditional Diheptyl Succinate (and) Capryloyl Glycerin/Sebacic Acid conditioner, this waterless and easy- LexFeel® N5 MB1 1.00 Copolymer rinse bar is highly concentrated with Coconut Oil Cocos Nucifera (Coconut) Oil 3.00 amino acid based conditioning agent, AminoSensyl™ HC. Shea Butter Butyrospermum Parkii (Shea) Butter 3.00 Spectrastat™1 Caprylhydroxamic Acid (and) Caprylyl Glycol (and) Glycerin 1.00 This creamy conditioner provides deep moisturization to combat Glycerin Glycerin 1.00 damage and dryness for healthier, Pink Salt & Water Lilly2 Fragrance 1.00 nourished tresses. 100.00 1INOLEX 2Lebermuth HC-1101 Curl Defining Spray Trade Name Ingredient (INCI) %(w/w) AminoSensyl™ HC1 Brassica Alcohol (and) Brassicyl Valinate Esylate 7.50 ® 1 LexFeel WOW-A Triheptanoin (and) C13-15 Alkane 1.00 A leave-in conditioner spray Diheptyl Succinate (and) LexFeel® N350 MB1 2.00 that creates smoother and Capryloyl Glycerin/Sebacic Acid Copolymer more defined curls. Quat-free Avocado Oil3 Persea Gratissima (Avocado) Oil 2.00 AminoSensyl™ HC provides Deionized Water Deionized Water 82.70 safe, nourishing conditioning Glycerin Glycerin 3.00 without weighing hair down, Spectrastat™ G2 ideal for a bouncy and hydrated Caprylhydroxamic Acid (and) Glyceryl Caprylate (and) Glycerin 1.00 Natural MB1 natural curl. PhytoTrace™ Saffron2 Crocus Sativus (Saffron) Flower Extract (and) Glycerin (and) Water 0.25 PhytoTrace™ Rice2 Oryza Sativa (Rice) Extract (and) Glycerin) (and) Water 0.25 Perfume Essence Fragrance 0.30 N262754 100.00 1INOLEX 2INOLEX Provence 3Now Solutions 4Carrubba HC-1100 Curl Definition and Smoothed Appearance from AminoSensyl™ HC AminoSensyl™ HC formulations provide consumer-perceivable benefits on hair European virgin curly hair treated with AminoSensyl™ HC Intensive Conditioning Bar and Curl Defining Spray has a smoother and more defined appearance with a tighter curl. 17 Curl Definition and Smoothed Appearance from AminoSensyl™ HC AminoSensyl™ HC formulations provide consumer-perceivable benefits on hair Textured (4C) hair treated with AminoSensyl™ HC Intensive Conditioning Bar and Curl Defining Spray has a smoother and more defined appearance with a tighter curl. Curl Defining Spray eliminates the greasy residue effect that is common with hair treatment oils. 18 Split End Repair Cream Trade Name Ingredient (INCI) %(w/w) Cetyl Alcohol Cetyl Alcohol 5.00 This luxurious cream uses the Diheptyl Succinate (and) Capryloyl Glycerin/Sebacic