Complete Product Catalogue 2019 (GB)

VETERINARY MEDICAMENTS PRODUCER

LIST OF PRODUCT BY THERAPEUTIC GROUPS

1. Canine vaccines 5. Poultry vaccines Biocan B 12 ORNIBRON H120 66 Biocan C 13 ORNIBRON H120+D274 67 Biocan DH + L 14 ORNIBUR Intermediate 68 Biocan DHPPi 15 ORNIBUR Intermediate Plus 69 Biocan DHPPi + L 16 ORNIMIX CLONE B1-Hitchner + H120 70 Biocan DHPPi + LR 17 ORNIPEST CLONE 71 Biocan DP 18 ORNIPRIM CLONE B1 72 Biocan L 19 SALGEN 73 Biocan LR 20 ORNIDUCK 74 Biocan M 21 ORNIVAC EDS 75 Biocan M Plus 22 ORNIVAC ND 76 Biocan P 23 ORNIVAC ND+GO 77 Biocan Puppy 24 ORNIVAC ND+GO+IB+EDS 78 Biocan R 25 ORNIVAC ND+IB2+EDS 79 Biocan T 26 PMV-Salmovac 80 Borrelym 3 27 Biocan NOVEL DHPPi 28 6. Rabbit vaccines Biocan NOVEL DHPPi/L4 29 MYXOREN 82 Biocan NOVEL DHPPi/L4R 30 PASORIN-OL 83 Biocan NOVEL Pi/L4 31 PESTORIN 84 Biocan NOVEL Puppy 32 PESTORIN RHDV2 85 Biocan NOVEL R 33 PESTORIN MORMYX 86 TRICHOPELEN 87 2. Cale vaccines BioBos BTV 1, 8 36 7. Swine vaccines BioBos BTV 8 37 BIOSUIS APP 2,9,11 90 BioBos IBR marker in 38 BIOSUIS M.hyo 91 BioBos IBR marker live 39 BIOSUIS PARVO L (6) 92 BioBos L 40 BIOSUIS ParvoEry 93 BioBos L(6) 41 BIOSUIS PRRS inact Eu+Am 94 BioBos Respi 2 intranasal 42 BIOSUIS Respi E 95 BioBos Respi 3 43 ERYPESTEN 96 BioBos Respi 4 44 ERYSEN 97 KOLIBIN RC Neo 45 ERYSIN SINGLE SHOT 98 MORAXEBIN Neo 46 KOLIERYSIN Neo 99 TRICHOBEN 47 KOLISIN Neo 100 TRICHOBEN AV 48 PARVOERYSIN 101 PARVOSIN-OL 102 3. Equine vaccines PESTISEN-C 103 BioEquin F 50 POLYPLEUROSIN APX PLUS IM 104 BioEquin FH 51 RHINISIN DNT 105 BioEquin FT 52 ROKOVAC NEO 106 BioEquin H 53 CLOTEID 4 54 8. Other vaccines FLUEQUIN 55 Lysvulpen 108 FLUEQUIN T 56 9. Hormones TRICHOEQUEN 57 LECIRELIN Bioveta 0.025 mg/ml 110 4. Feline vaccines OESTROPHAN 0.25 mg/ml 111 Biofel B 60 OXYTOCIN BIO 5 IU/ml 112 BIOFEL M Plus 61 REMOPHAN 75 μg/ml 113 BIOFEL PCH 62 SERGON 500 IU/ml 114 BIOFEL PCHR 63 SERGON PG 400/200 IU 115 LIST OF PRODUCT BY THERAPEUTIC GROUPS

10. Anmicrobial 15. Intramammary AMOXICILLIN Bioveta 150 mg/ml LA 118 GAMARET 168 BIOVETA AMOXICILIN 100 mg/g 119 INTRAMAR LC 169 BIOVETA COLISTIN 1 200 000 IU/g 120 LINEOMAM LC 170 COTRIMAZIN BIOVETA 121 GAMMAVIT BIO 122 16. Vitamins, minerals IVATYL TAR 180.000 IU/ml 123 ADE - vit. 172 STREPTONAMID 124 ENERGY BOOSTER BIOVETA 173 FRESH HORSE 174 11. Anparazics KELPA BIOVETA 175 Anparasic CANISSHAMPOO 126 MULTIVIT – MINERAL 176 BIO KILL 2.5 mg/ml 127 PLASTIN 177 BIOMEC 10 mg/ml 128 VITA E SELEN 178 BLUE repellent 129 VITAPLASTIN FORTE 179 CANIVERM forte 130 CANIVERM mite 131 17. Joint nutrion CANIVERM oral paste 132 Atlet BS 182 EQUIMOXIN 18.92 mg/g 133 Atlet MSM 183 EQUISTRONG 400 mg/g 134 Atlet syrup 184 EQUIVERM Oral Paste 135 HYALCHONDRO DC Plus 185 ESB3 Bio 300 mg/g 136 HYALCHONDRO EC Plus 186 FIPRON 50 mg spot-on cats 137 HYALURONAN BIOVETA 10 mg/ml 187 FIPRON 67 mg spot-on S 138 FIPRON 134 mg spot-on M 139 18. Dermatologics FIPRON 268 mg spot-on L 140 ALAPTID 190 FIPRON 402 mg spot-on XL 141 BIODEXIN ear loon 191 FIPRON 2.5 mg/ml spray 142 BIODEXIN shampoo 192 GREEN repellent 143 BIOPIROX 10 mg/ml 193 SULFADIMIDIN BIOVETA 20 g 144 OTIBIOVIN ear drops 194 TOP SPOT ON STRONGER 16.25 g 145 OTIMIX ear drops 195 TOP SPOT ON STRONGER 650 mg 146 OTIPUR ear drops 196 TOP SPOT ON DOG S 147 OTOFIN 197 TOP SPOT ON DOG M 148 PIX FAGI 198 TOP SPOT ON DOG L 149 19. Ansera 12. Ananaemics CLOTEAN 200 FERRIBION 100 mg/ml 152 IMULYZIN 201 GAFERVIT 153 POLYEQUAN 202 GAFERVIT mite 154 POLYGLOB 203 13. Anaesthecs 20. Environmental disinfectants and inseccides NALGOSED 10 mg/ml 156 BIO KILL insekcidum 206 NARKAMON 100 mg/ml 157 IVASAN pets 207 NARKAMON 50 mg/ml 158 IVASAN farm 208 ROMETAR 20 mg/ml 159 IVASAN spray 209 Sedan 35 mg/ml 160 21. Others XYLASED 100 161 AQUA VIVA 212 XYLASED 500 162 COFFEINUM BIOVETA 125 mg/ml 213 14. Anaesthecs JODOUTER 100 mg/ml 214 Meloxicam Bioveta 5 mg/ml 164 LOTAGEN 360 mg/ml 215 Meloxicam Bioveta 1,5 mg/ml 165 LOTAGEN injector 216 PENBITAL 400 mg/ml 217 PROFYMAST emulsio 218 LIST OF PRODUCTS BY TARGET SPECIES

DOG NARKAMON 100 mg/ml 157 NARKAMON 50 mg/ml 158 ADE - vit. 172 OTIBIOVIN ear drops 194 ALAPTID 190 OTIMIX ear drops 195 AMOXICILLIN Bioveta 150 mg/ml LA 118 OTIPUR ear drops 196 Anparasic CANISSHAMPOO 126 OTOFIN 197 Atlet syrup 184 OXYTOCIN BIO 5 IU/ml 112 BIO KILL 2.5 mg/ml 127 PENBITAL 400 mg/ml 217 Biocan B 12 PIX FAGI 198 Biocan C 13 PLASTIN 177 Biocan DH + L 14 POLYGLOB 203 Biocan DHPPi 15 ROMETAR 20 mg/ml 159 Biocan DHPPi + L 16 Sedan 35 mg/ml 160 Biocan DHPPi + LR 17 SERGON 500 IU/ml 114 Biocan DP 18 STREPTONAMID 124 Biocan L 19 TOP SPOT ON DOG L 149 Biocan LR 20 TOP SPOT ON DOG M 148 Biocan M 21 TOP SPOT ON DOG S 147 Biocan M Plus 22 TOP SPOT ON STRONGER 650 mg 146 Biocan NOVEL DHPPi 28 VITAPLASTIN FORTE 179 Biocan NOVEL DHPPi/L4 29 Biocan NOVEL DHPPi/L4R 30 Biocan NOVEL Pi/L4 31 CAT Biocan NOVEL Puppy 32 Biocan NOVEL R 33 ALAPTID 190 Biocan P 23 Atlet syrup 184 Biocan Puppy 24 Biocan M 21 Biocan R 25 Biocan R 25 Biocan T 26 BIODEXIN shampoo 192 BIODEXIN ear loon 191 Biofel B 60 BIODEXIN shampoo 192 BIOFEL M Plus 61 BIOPIROX 10 mg/ml 193 BIOFEL PCH 62 Borrelym 3 27 BIOFEL PCHR 63 CANIVERM forte 130 BIOPIROX 10 mg/ml 193 CANIVERM mite 131 CANIVERM forte 130 CANIVERM oral paste 132 CANIVERM mite 131 CLOTEAN 200 CANIVERM oral paste 132 CLOTEID 4 54 CLOTEAN 200 COFFEINUM BIOVETA 125 mg/ml 213 COFFEINUM BIOVETA 125 mg/ml 213 FERRIBION 100 mg/ml 152 FIPRON 2.5 mg/ml spray 142 FIPRON 134 mg spot-on M 139 FIPRON 50 mg spot-on cats 137 FIPRON 2.5 mg/ml spray 142 HYALURONAN BIOVETA 10 mg/ml 187 FIPRON 268 mg spot-on L 140 KELPA BIOVETA 175 FIPRON 402 mg spot-on XL 141 LOTAGEN 360 mg/ml 215 FIPRON 67 mg spot-on S 138 Meloxicam Bioveta 5 mg/ml 164 HYALCHONDRO DC Plus 185 MULTIVIT – MINERAL 176 HYALURONAN BIOVETA 10 mg/ml 187 NALGOSED 10 mg/ml 156 KELPA BIOVETA 175 NARKAMON 100 mg/ml 157 LOTAGEN 360 mg/ml 215 NARKAMON 50 mg/ml 158 Meloxicam Bioveta 1,5 mg/ml 165 OTIBIOVIN ear drops 194 Meloxicam Bioveta 5 mg/ml 164 OTIPUR ear drops 196 MULTIVIT – MINERAL 176 OTOFIN 197 NALGOSED 10 mg/ml 156 PENBITAL 400 mg/ml 217 ROMETAR 20 mg/ml 159 LIST OF PRODUCTS BY TARGET SPECIES

HORSE MULTIVIT – MINERAL 176 MYXOREN 82 ADE - vit. 172 PASORIN-OL 83 ALAPTID 190 PENBITAL 400 mg/ml 217 Atlet BS 182 PESTORIN 84 Atlet MSM 183 PESTORIN MORMYX 86 BioEquin F 50 PESTORIN RHDV2 85 BioEquin FH 51 PIX FAGI 198 BioEquin FT 52 SERGON 500 IU/ml 114 BioEquin H 53 SULFADIMIDIN BIOVETA 20 g 144 BIOPIROX 10 mg/ml 193 TRICHOPELEN 87 BLUE repellent 129 VITAPLASTIN FORTE 179 CLOTEAN 200 CLOTEID 4 54 COFFEINUM BIOVETA 125 mg/ml 213 EXOTIC BIRDS COTRIMAZIN BIOVETA 121 ENERGY BOOSTER BIOVETA 173 ALAPTID 190 EQUIMOXIN 18.92 mg/g 133 BIO KILL 2.5 mg/ml 127 EQUISTRONG 400 mg/g 134 BIOPIROX 10 mg/ml 193 EQUIVERM Oral Paste 135 MULTIVIT – MINERAL 176 FERRIBION 100 mg/ml 152 PIX FAGI 198 FLUEQUIN 55 VITAPLASTIN FORTE 179 FLUEQUIN T 56 FRESH HORSE 174 REPTILE GREEN repellent 143 HYALCHONDRO EC Plus 186 ALAPTID 190 HYALURONAN BIOVETA 10 mg/ml 187 BIOPIROX 10 mg/ml 193 MULTIVIT – MINERAL 176 MULTIVIT – MINERAL 176 NALGOSED 10 mg/ml 156 NARKAMON 100 mg/ml 157 CATTLE NARKAMON 50 mg/ml 158 OESTROPHAN 0.25 mg/ml 111 ADE - vit. 172 OXYTOCIN BIO 5 IU/ml 112 ALAPTID 190 PENBITAL 400 mg/ml 217 AMOXICILLIN Bioveta 150 mg/ml LA 118 PIX FAGI 198 AQUA VIVA 212 POLYEQUAN 202 BioBos BTV 1, 8 36 ROMETAR 20 mg/ml 159 BioBos BTV 8 37 Sedan 35 mg/ml 160 BioBos IBR marker in 38 STREPTONAMID 124 BioBos IBR marker live 39 TOP SPOT ON STRONGER 16.25 g 145 BioBos L 40 TRICHOEQUEN 57 BioBos L(6) 41 VITAPLASTIN FORTE 179 BioBos Respi 2 intranasal 42 XYLASED 100 161 BioBos Respi 3 43 XYLASED 500 162 BioBos Respi 4 44 Biocan R 25 BIOMEC 10 mg/ml 128 RABBIT BIOVETA AMOXICILIN 100 mg/g 119 ADE - vit. 172 BIOVETA COLISTIN 1 200 000 IU/g 120 ALAPTID 190 CLOTEAN 200 BIOPIROX 10 mg/ml 193 CLOTEID 4 54 CLOTEAN 200 COFFEINUM BIOVETA 125 mg/ml 213 ESB3 Bio 300 mg/g 136 FERRIBION 100 mg/ml 152 LECIRELIN Bioveta 0.025 mg/ml 110 GAMARET 168 LIST OF PRODUCTS BY TARGET SPECIES

GAMMAVIT BIO 122 GAFERVIT mite 154 IMULYZIN 201 IVATYL TAR 180.000 IU/ml 123 INTRAMAR LC 169 JODOUTER 100 mg/ml 214 IVATYL TAR 180.000 IU/ml 123 KOLIERYSIN Neo 99 JODOUTER 100 mg/ml 214 KOLISIN Neo 100 KOLIBIN RC Neo 45 LOTAGEN 360 mg/ml 215 LECIRELIN Bioveta 0.025 mg/ml 110 LOTAGEN injector 216 LINEOMAM LC 170 MULTIVIT – MINERAL 176 LOTAGEN 360 mg/ml 215 NARKAMON 50 mg/ml 158 LOTAGEN injector 216 OESTROPHAN 0.25 mg/ml 111 MORAXEBIN Neo 46 OXYTOCIN BIO 5 IU/ml 112 MULTIVIT – MINERAL 176 PARVOERYSIN 101 NARKAMON 50 mg/ml 158 PARVOSIN-OL 102 OESTROPHAN 0.25 mg/ml 111 PENBITAL 400 mg/ml 217 OXYTOCIN BIO 5 IU/ml 112 PESTISEN-C 103 PENBITAL 400 mg/ml 217 PIX FAGI 198 PIX FAGI 198 PLASTIN 177 PROFYMAST emulsio 218 POLYPLEUROSIN APX PLUS IM 104 REMOPHAN 75 μg/ml 113 REMOPHAN 75 μg/ml 113 ROMETAR 20 mg/ml 159 RHINISIN DNT 105 SERGON 500 IU/ml 114 ROKOVAC NEO 106 STREPTONAMID 124 SERGON 500 IU/ml 114 SULFADIMIDIN BIOVETA 20 g 144 SERGON PG 400/200 IU 115 TRICHOBEN 47 SULFADIMIDIN BIOVETA 20 g 144 TRICHOBEN AV 48 VITA E SELEN 178 VITA E SELEN 178 VITAPLASTIN FORTE 179 VITAPLASTIN FORTE 179 XYLASED 100 161 XYLASED 500 162 GOAT ADE - vit. 172 ALAPTID 190 Biocan R 25 SWINE CLOTEAN 200 ADE - vit. 172 CLOTEID 4 54 ALAPTID 190 COFFEINUM BIOVETA 125 mg/ml 213 AMOXICILLIN Bioveta 150 mg/ml LA 118 FERRIBION 100 mg/ml 152 Biocan R 25 LOTAGEN 360 mg/ml 215 BIOMEC 10 mg/ml 128 MULTIVIT – MINERAL 176 BIOSUIS APP 2,9,11 90 NARKAMON 50 mg/ml 158 BIOSUIS M.hyo 91 OXYTOCIN BIO 5 IU/ml 112 BIOSUIS PARVO L (6) 92 PENBITAL 400 mg/ml 217 BIOSUIS ParvoEry 93 PIX FAGI 198 BIOSUIS PRRS inact Eu+Am 94 PROFYMAST emulsio 218 BIOSUIS Respi E 95 SERGON 500 IU/ml 114 BIOVETA AMOXICILIN 100 mg/g 119 VITAPLASTIN FORTE 179 BIOVETA COLISTIN 1 200 000 IU/g 120 CLOTEAN 200 COFFEINUM BIOVETA 125 mg/ml 213 SHEEP ERYPESTEN 96 ADE - vit. 172 ERYSEN 97 ALAPTID 190 ERYSIN SINGLE SHOT 98 Biocan R 25 FERRIBION 100 mg/ml 152 BIOMEC 10 mg/ml 128 GAFERVIT 153 CLOTEAN 200 LIST OF PRODUCTS BY TARGET SPECIES

CLOTEID 4 54 COFFEINUM BIOVETA 125 mg/ml 213 FOX FERRIBION 100 mg/ml 152 Lysvulpen 108 LOTAGEN 360 mg/ml 215 MULTIVIT – MINERAL 176 NARKAMON 50 mg/ml 158 ENVIRONMENT OXYTOCIN BIO 5 IU/ml 112 PENBITAL 400 mg/ml 217 BIO KILL insekcidum 206 PIX FAGI 198 IVASAN pets 207 PROFYMAST emulsio 218 IVASAN farm 208 SERGON 500 IU/ml 114 IVASAN spray 209 SULFADIMIDIN BIOVETA 20 g 144 VITA E SELEN 178 VITAPLASTIN FORTE 179

POULTRY ALAPTID 190 BIOVETA AMOXICILIN 100 mg/g 119 BIOVETA COLISTIN 1 200 000 IU/g 120 ESB3 Bio 300 mg/g 136 MULTIVIT – MINERAL 176 dog ORNIBRON H120 66 ORNIBRON H120+D274 67 ORNIBUR Intermediate 68 cat ORNIBUR Intermediate Plus 69 ORNIDUCK 74 horse ORNIMIX CLONE B1-Hitchner + H120 70 ORNIPEST CLONE 71 rabbit ORNIPRIM CLONE B1 72 ORNIVAC EDS 75 exoc birds ORNIVAC ND 76 ORNIVAC ND+GO 77 ORNIVAC ND+GO+IB+EDS 78 reple ORNIVAC ND+IB2+EDS 79 PIX FAGI 198 cale PLASTIN 177 PMV-Salmovac 80 swine SALGEN 73 SULFADIMIDIN BIOVETA 20 g 144 VITAPLASTIN FORTE 179 goat

sheep FUR-BEARING ANIMAL Biocan R 25 poultry PENBITAL 400 mg/ml 217 PIX FAGI 198 fur-bearing animal TRICHOPELEN 87 VITAPLASTIN FORTE 179 fox

environment ALPHABETICAL LIST OF PRODUCTS

ADE - vit. 172 BIOSUIS PARVO L (6) 92 ALAPTID 190 BIOSUIS ParvoEry 93 AMOXICILLIN Bioveta 150 mg/ml LA 118 BIOSUIS PRRS inact Eu+Am 94 Anparasic CANISSHAMPOO 126 BIOSUIS Respi E 95 AQUA VIVA 212 BIOVETA AMOXICILIN 100 mg/g 119 Atlet BS 182 BIOVETA COLISTIN 1 200 000 IU/g 120 Atlet MSM 183 BLUE repellent 129 Atlet syrup 184 Borrelym 3 27 BIO KILL 2.5 mg/ml 127 CANIVERM forte 130 BIO KILL insekcidum 206 CANIVERM mite 131 BioBos BTV 1, 8 36 CANIVERM oral paste 132 BioBos BTV 8 37 CLOTEAN 200 BioBos IBR marker in 38 CLOTEID 4 54 BioBos IBR marker live 39 COFFEINUM BIOVETA 125 mg/ml 213 BioBos L 40 COTRIMAZIN BIOVETA 121 BioBos L(6) 41 ENERGY BOOSTER BIOVETA 173 BioBos Respi 2 intranasal 42 EQUIMOXIN 18.92 mg/g 133 BioBos Respi 3 43 EQUISTRONG 400 mg/g 134 BioBos Respi 4 44 EQUIVERM Oral Paste 135 Biocan B 12 ERYPESTEN 96 Biocan C 13 ERYSEN 97 Biocan DH + L 14 ERYSIN SINGLE SHOT 98 Biocan DHPPi 15 ESB3 Bio 300 mg/g 136 Biocan DHPPi + L 16 FERRIBION 100 mg/ml 152 Biocan DHPPi + LR 17 Biocan DP 18 FIPRON 134 mg spot-on M 139 Biocan L 19 FIPRON 2.5 mg/ml spray 142 Biocan LR 20 FIPRON 268 mg spot-on L 140 Biocan M 21 FIPRON 402 mg spot-on XL 141 Biocan M Plus 22 FIPRON 50 mg spot-on cats 137 Biocan NOVEL DHPPi 28 FIPRON 67 mg spot-on S 138 Biocan NOVEL DHPPi/L4 29 FLUEQUIN 55 Biocan NOVEL DHPPi/L4R 30 FLUEQUIN T 56 Biocan NOVEL Pi/L4 31 FRESH HORSE 174 Biocan NOVEL Puppy 32 GAFERVIT 153 Biocan NOVEL R 33 GAFERVIT mite 154 Biocan P 23 GAMARET 168 Biocan Puppy 24 GAMMAVIT BIO 122 Biocan R 25 GREEN repellent 143 Biocan T 26 BIODEXIN ear loon 191 HYALCHONDRO DC Plus 185 BIODEXIN shampoo 192 HYALCHONDRO EC Plus 186 BioEquin F 50 HYALURONAN BIOVETA 10 mg/ml 187 BioEquin FH 51 IMULYZIN 201 BioEquin FT 52 INTRAMAR LC 169 BioEquin H 53 IVASAN farm 208 Biofel B 60 IVASAN pets 207 BIOFEL M Plus 61 IVASAN spray 209 BIOFEL PCH 62 IVATYL TAR 180.000 IU/ml 123 BIOFEL PCHR 63 JODOUTER 100 mg/ml 214 BIOMEC 10 mg/ml 128 BIOPIROX 10 mg/ml 193 KELPA BIOVETA 175 BIOSUIS APP 2,9,11 90 KOLIBIN RC Neo 45 BIOSUIS M.hyo 91 ALPHABETICAL LIST OF PRODUCTS

KOLIERYSIN Neo 99 ROMETAR 20 mg/ml 159 KOLISIN Neo 100 SALGEN 73 LECIRELIN Bioveta 0.025 mg/ml 110 Sedan 35 mg/ml 160 LINEOMAM LC 170 SERGON 500 IU/ml 114 LOTAGEN 360 mg/ml 215 SERGON PG 400/200 IU 115 LOTAGEN injector 216 STREPTONAMID 124 Lysvulpen 108 SULFADIMIDIN BIOVETA 20 g 144 Meloxicam Bioveta 1,5 mg/ml 165 TOP SPOT ON DOG L 149 Meloxicam Bioveta 5 mg/ml 164 TOP SPOT ON DOG M 148 MORAXEBIN Neo 46 TOP SPOT ON DOG S 147 MULTIVIT – MINERAL 176 TOP SPOT ON STRONGER 16.25 g 145 MYXOREN 82 TOP SPOT ON STRONGER 650 mg 146 NALGOSED 10 mg/ml 156 TRICHOBEN 47 NARKAMON 100 mg/ml 157 TRICHOBEN AV 48 NARKAMON 50 mg/ml 158 TRICHOEQUEN 57 TRICHOPELEN 87 OESTROPHAN 0.25 mg/ml 111 ORNIBRON H120 66 VITA E SELEN 178 ORNIBRON H120+D274 67 VITAPLASTIN FORTE 179 ORNIBUR Intermediate 68 XYLASED 100 161 ORNIBUR Intermediate Plus 69 XYLASED 500 162 ORNIDUCK 74 ORNIMIX CLONE B1-Hitchner + H120 70 dog ORNIPEST CLONE 71 ORNIPRIM CLONE B1 72 cat ORNIVAC EDS 75 ORNIVAC ND 76 ORNIVAC ND+GO 77 horse ORNIVAC ND+GO+IB+EDS 78 ORNIVAC ND+IB2+EDS 79 rabbit OTIBIOVIN ear drops 194 OTIMIX ear drops 195 exoc birds OTIPUR ear drops 196 OTOFIN 197 OXYTOCIN BIO 5 IU/ml 112 reple PARVOERYSIN 101 PARVOSIN-OL 102 cale PASORIN-OL 83 PENBITAL 400 mg/ml 217 swine PESTISEN-C 103 PESTORIN 84 goat PESTORIN MORMYX 86 PESTORIN RHDV2 85 PIX FAGI 198 sheep PLASTIN 177 PMV-Salmovac 80 poultry POLYEQUAN 202 POLYGLOB 203 fur-bearing animal POLYPLEUROSIN APX PLUS IM 104 PROFYMAST emulsio 218 fox REMOPHAN 75 μg/ml 113 RHINISIN DNT 105 environment ROKOVAC NEO 106 CANINE VACCINES

Biocan B Biocan C Biocan DH + L Biocan DHPPi Biocan DHPPi + L Biocan DHPPi + LR Biocan DP Biocan L Biocan LR Biocan M Biocan M Plus Biocan P Biocan Puppy Biocan R Biocan T Borrelym 3 Biocan NOVEL DHPPi Biocan NOVEL DHPPi/L4 Biocan NOVEL DHPPi/L4R Biocan NOVEL Pi/L4 Biocan NOVEL Puppy 1 Biocan NOVEL R 1 Canine vaccines

Great protecon against two the most common European serogroups of Borrelia spp.

Biocan B suspension for injecon Vaccine against Lyme disease, inacvated

COMPOSITION DOSAGE STORAGE Composion 1 ml: 1 ml irrespecve of age, weight Store in a dark and dry place Acve substances: and race of the individual, but at the temperature between Borrelia burgdorferi inacvata: not early than at the age of 2 °C – 8 °C. The vaccine shall Borrelia garinii RP  1* 12 weeks. not be allowed to freeze. Borrelia afzelii RP  1* Apply the vaccine: PACKAGE * relave potency (RP) in - subcutaneously, preferably 2 × 1 ml, 10 × 1 ml, 20 × 1 ml, comparison with reference serum at the region behind the blade- 50 × 1 ml, 100 × 1 ml gained from the animals bone vaccinated with batch which - intramuscularly, preferably to sasﬁed in challenge test on the musculature of the pelvis target animal extremity. TARGET SPECIES In case of the primary Dogs. vaccinaons, the re-vaccinaon shall be performed at the interval INDICATION of 14–21 days. The vaccinaon For the acve immunizaon scheme should be speciﬁed of dogs against Lyme disease by the veterinarian at the age of 12 weeks and in dependence on the infecon above. situaon. It can be applied simultaneously with other vaccines of Biocan SHELF LIFE type, but always each vaccine 24 months shall be applied to the individual spot (preferably on the opposite body side).

12 1 Canine vaccines

Vaccine providing protecon against the next viral pathogen of gastrointesnal tract

Biocan C suspension for injecon Inacvated canine coronavirus vaccine

COMPOSITION DOSAGE SHELF LIFE Composion – 1 ml: 1 ml regardless of age, weight 24 months. Use the vaccine Acve substance: and breed of the individual. immediately aer opening. Coronavirus gastroenteridis The vaccine is administered STORAGE infecosae canis, prior to subcutaneously at the age of 6,5 Store in a dark and dry place inacvaon min. 10 TCID50 5 weeks and above; revaccinaon under a temperature TARGET SPECIES is performed in 14 to 21 days of 2 oC – 8 oC. Dogs. aer primovaccinaon. The vaccine must not get frozen! To maintain a permanent INDICATION immunity, it is recommended PACKAGE For acve immunisaon from to revaccinate in six-month 10 × 1 ml, 20 × 1 ml, 50 × 1 ml, 5th week of age against canine intervals. 100 × 1 ml coronavirus.

13 1 Canine vaccines

Unique angenic combinaon for special epidemiological situaon

Biocan DH + L lyophilisate for the preparaon of injecon suspension with diluent Vaccine against canine distemper (CDV), inf. hepas (CAV-1), inf. laryngotracheis (CAV-2) vivid and leptospirosis (L. icterohaemorrhagiae inact., L. canicola inact., L. grippotyphosa inact.) in dogs inacvated.

COMPOSITION INDICATION SHELF-LIFE Component DH (freeze-dried): For the acve immunizaon of 24 months. When diluted, Virus febris contagiosae canis dogs against distemper, infecous the vaccine shall be used 3.0 4.5 50 min. 10 TCID50, max. 10 TCID hepas, infecous immediately. Virus laryngotracheidis laryngotracheis and the most STORAGE contagiosae canis frequently occurred leptospira 3.5 4.5 Store in a dry and dark place min. 10 TCID50, max. 10 TCID50 serovars (Leptospira at the temperature of 2 °C – 8 °C. Nutrimentum pro lyophilisaone icterohaemorrhagiae, Leptospira Do not freeze! ad 1 ml canicola, Leptospira Component L (soluon): grippotyphosa) in dogs at the age PACKAGE Leptospira icterohaemorrhagiae of 8 weeks and above. 5 × 1 ml of the vaccine Biocan L inact. Use during pregnancy and + 5 × 1 ml of the lyophilised min. tre 32 defined MAT*) lactaon vaccine Biocan DH Leptospira canicola inact. Vaccinaon should be avoided 10 × 1 ml of the vaccine Biocan L min. tre 32 defined MAT*) during the last two weeks before + 10 × 1 ml of the lyophilised Leptospira grippotyphosa inact. delivery for the general purposes vaccine Biocan DH min. tre 32 defined MAT*) (handling with pregnant animal, 50 × 1 ml of the vaccine Biocan L *) geometrical mean of tres of specific etc.). + 50 × 1 ml of the lyophilised anbodies defined by microagglunaon vaccine Biocan DHl test DOSAGE TARGET SPECIES Dose – 1 ml irrespecve of age, Dogs. weight and breed.

14 1 Canine vaccines

Live vaccine for the ﬁrst shot in puppies at the age of six weeks

Biocan DHPPi lyophilisate for preparaon of soluon for injecon Live vaccine against canine distemper (CDV), inf. laryngotracheis (CAV-2), inf. hepas (CAV-1), parvovirosis (CPV-2), parainﬂuenza (CPIV-2) in dogs.

COMPOSITION INTERACTION STORAGE Composion – 1 ml: The vaccine Biocan DHPPi can be Store in a dry and dark place Freeze-dried component: used separately or at the temperature of 2 °C – 8 °C. Virus febris contagiosae canis simultaneously with other 3,0 4,5 PACKAGE min. 10 TCID50, max.10 TCID50 vaccines Biocan according to 5 × 1 ml of vaccine Biocan DHPPi Virus laryngotracheidis recommended vaccinaon + 5 × 1 ml of diluent contagiosae canis min. 103,5 scheme or in group with fluid 4,5 50 10 × 1 ml of vaccine Biocan TCID50, max.10 TCID vaccines Biocan (LR, L, C, R). DHPPi + 10 × 1 ml of diluent Parvovirus enteridis canis 4,5 5,5 DOSAGE 50 × 1 ml of vaccine Biocan min. 10 TCID50, max.10 TCID50 The dose is 1 ml regardless of DHPPi + 50 × 1 ml of diluent Virus parainfluensis canis 3,0 4,2 age, weight and breed of the min. 10 TCID50, max.10 TCID50 individual, vaccinaon may be TARGET SPECIES first performed during the sixth Dogs. week of age. INDICATION Method of administraon – For the acve immunizaon of subcutaneously, preferably in dogs against distemper, infecous zone behind the shoulder-blade. hepas, infecous SHELF LIFE laryngotracheis, parvovirosis 24 months. When diluted, and parainfluenza. the vaccine shall be used immediately.

15 1 Canine vaccines

Combinaon viral angens and three serogroups of Leptospira spp. for purpose of revaccinaon at the age of eight weeks

Biocan DHPPi + L lyophilisate for the preparaon of injecon suspension with diluent Vaccine against canine distemper (CDV), inf. hepas (CAV-1), inf. laryngotracheis (CAV-2), parvovirosis (CPV-2), parainﬂuenza (CPIV-2) vivid and leptospirosis (L. icterohaemorrhagiae inact., L. canicola inact., L. grippotyphosa inact.) in dogs inacvated

COMPOSITION hepas, infecous immunity of the animals Freeze-dried component laryngotracheis, parvovirosis, vaccinated. Virus febris contagiosae canis parainfluenza and the most 3.0 4.5 SHELF LIFE min. 10 TCID50, max. 10 TCID50 frequently occurred leptospira 24 months.When diluted, Virus laryngotracheidis serovars (Leptospira the vaccine shall be used contagiosae canis icterohaemorrhagiae, Leptospira 3.5 4.5 immediately. min. 10 TCID50, max. 10 TCID50 canicola, Leptospira Parvovirus enteridis canis grippotyphosa) in dogs at the age STORAGE min. 104.5 TCID , max. 105.5 TCID of 8 weeks and above. Store in a dry and dark place 50 50 at the temperature of 2 °C – 8 °C. Virus parainfluensis canis DOSAGE 3.0 4.2 Do not freeze! min. 10 TCID50, max. 10 TCID50 Dose - 1 ml irrespecve of age, Liquid component weight and breed. PACKAGE Leptospira icterohaemorrhagiae Vaccine is administered 5 × 1 ml of freeze-dried DHPPi inact. subcutaneously, preferably in component + 5 × 1 ml of L min. tre 32 defined MAT*) zone behind the shoulder-blade component Leptospira canicola inac. at the age of 8 weeks and above, 10 × 1 ml of freeze-dried DHPPi min. tre 32 defined MAT*) the re-vaccinaon shall be done component + 10 × 1 ml of L Leptospira grippotyphosa inact. within 14–21 day. component min. tre 32 defined MAT*) Immunity is starng aer 14 days 50 × 1 ml of freeze-dried DHPPi *) geometrical mean of tres of specific aer first vaccinaon and firm component + 50 × 1 ml of L anbodies defined by microagglunaon component test immunity is developed aer TARGET SPECIES further 14 days aer re- Dogs vaccinaon. The revaccinaon shall be performed within INDICATION 14–21 days. The revaccinaon For the acve immunizaon of should be repeated every year dogs against distemper, infecous in order to keep permanent

16 1 Canine vaccines

For eﬀecve ﬁnal vaccinaon of puppies at the age of 12 weeks

Biocan DHPPi + LR lyophilisate for the preparaon of injecon suspension with diluent Vaccine against canine distemper (CDV), inf. hepas (CAV-1), inf. laryngotracheis (CAV-2), parvovirosis (CPV-2), parainﬂuenza (CPIV-2) vivid and leptospirosis and rabies in dogs inacvated

COMPOSITION INDICATION Immunity is starng aer 14 days Component DHPPi - lyophilizate For the acve immunizaon of aer first vaccinaon and firm Acve substances: dogs against distemper, infecous immunity is developed aer Virus febris contagiosae canis hepas, infecous further 14 days aer 3,0 4,5 min. 10 , max. 10 TCID50 laryngotracheis, parvovirosis, re-vaccinaon. The revaccinaon Virus laryngotracheidis parainfluenza, rabies and the shall be performed within contagiosae canis most frequently occurred 14–21 days. 3,5 4,5 min. 10 , max. 10 TCID50 leptospira serovars (Leptospira The revaccinaon should be Parvovirus enteridis canis icterohaemorrhagiae, Leptospira repeated every year in order to 4,5 5,5 min. 10 , max. 10 TCID50 canicola, Leptospira keep permanent immunity Virus parainfluensis canis grippotyphosa) in dogs at the age of the animals vaccinated. 3,0 4,2 min. 10 , max. 10 TCID50 of 12 weeks and above. SHELF LIFE Component LR - diluent INTERACTION WITH OTHER 24 months. Acve substances: MEDICINAL PRODUCTS AND Virus rabiei inacvated STORAGE OTHER FORMS OF Store in a dry and dark place at min. 2 IU INTERACTION Leptospira icterohaemorrhagiae the temperature of 2 °C – 8 °C. The vaccine Biocan DHPPi + LR Do not freeze! inact. can be used separately or min. tre 32 defined by MAT*) simultaneously with vaccines PACKAGE Leptospira canicola inact. Biocan C, Biocan M Plus, 5 × 1 ml of the vaccine Biocan LR min. tre 32 defined by MAT*) Biocan B. + 5 × 1 ml of the lyophilised Leptospira grippotyphosa inact. vaccine Biocan DHPPi min. tre 32 defined by MAT*) DOSAGE 10 × 1 ml of the vaccine Biocan *) geometrical mean of tres of specific 1 ml irrespecve of weight of LR + 10 × 1 ml of the lyophilised anbodies defined by microagglunaon breed, at the age of 12 weeks and vaccine Biocan DHPPi test above. 50 × 1 ml of the vaccine Biocan TARGET SPECIES Method of administraon – LR + 50 × 1 ml of the lyophilised Dogs. subcutaneously. vaccine Biocan DHPPi.

17 1 Canine vaccines

Vaccine contains live, highly immunogenic strain of parvovirus inducing fast onset of immunity

Biocan DP lyophilisate for suspension for injecon with diluent Vaccine against canine distemper (CDV) and canine parvovirus (CPV-2), live

COMPOSITION DOSAGE PACKAGE Lyophilisate: Dose: 1 ml regardless of age, 5 × 1 ml of lyophilised vaccine Virus febris contagiosae canis: weight and breed of the Biocan DP + 5 × 1 ml of diluent 3.0 4.8 10 – 10 TCID50 individual, but not earlier than 10 × 1 ml of lyophilised vaccine Parvovirus enteridis canis: at the 6th week of age. Biocan DP + 10 × 1 ml of diluent 4.5 6.0 10 – 10 TCID50 Method of administraon – 50 × 1 ml of lyophilised vaccine Excipients: subcutaneous, preferably in the Biocan DP + 50 × 1 ml of diluent lyophilisaon medium ad 1 ml region behind the shoulder blade. TARGET SPECIES SHELF LIFE Dogs. 24 months, the vaccine should be INDICATIONS used immediately aer diluon. For acve immunizaon of dogs STORAGE against canine distemper and Store in a dry and dark place canine parvovirus from 6th week at 2 °C – 8 °C. of age. The onset of immunity is 14 to 28 days aer the second vaccinaon. The duraon of immunity to both the angens is at least one year.

18 1 Canine vaccines

The content of three recommended serovars of Leptospira species

Biocan L suspension for injecon Inacvated vaccine against leptospirosis in dogs

COMPOSITION DOSAGE STORAGE Acve substances: 1 ml regardless of age, weight Store in a dark and dry place Leptospira icterohaemorrhagiae and breed of the individual. under a temperature inact. The vaccine is administered of 2 °C – 8 °C. min. tre 32 defined by MAT*) subcutaneously at the age The vaccine must not get frozen! Leptospira canicola inact. of 8 weeks or more. PACKAGE min. tre 32 defined by MAT*) Revaccinaon is performed 10 × 1 ml, 20 × 1 ml, 50 × 1 ml, Leptospira grippotyphosa inact. in 14 to 28 days aer 100 × 1 ml. min. tre 32 defined by MAT*) primovaccinaon so that *) geometrical mean of tres of specific revaccinaon was performed anbodies defined by microagglunaon test at least at the age of 12 weeks of the puppies. TARGET SPECIES Annual revaccinaon is Dogs recommended in order to INDICATION maintain permanent immunity. For acve immunisaon of dogs SHELF LIFE from the age of 8 weeks against 24 months. Use the vaccine leptospiral serovars contained immediately aer opening. in vaccine.

19 1 Canine vaccines

A combinaon three Leptospira serovars and rabies virus in one vial

Biocan LR suspension for injecon Inacvated vaccine against leptospirosis and rabies in dogs

COMPOSITION A/ Biocan LR vaccine may be Primary vaccinaon at the age Acve substances: used as a diluent for other of 12 weeks. Virus rabiei inacvated lyophilised Biocan vaccines Vaccinaon with Biocan LR min. 2 IU (for example DHPPi, DHP, DP, P). vaccine with subsequent Leptospira icterohaemorrhagiae B/ Biocan LR vaccine may be revaccinaon with Biocan L inact. administered simultaneously or vaccine within an interval min. tre 32 defined by MAT*) with liquid vaccines Biocan C, of 14–28 days. Leptospira canicola inact. Biocan B and Biocan M To maintain permanent immunity min. tre 32 defined by MAT*) (possibly with lyophilised vaccine against leptospira and rabies, Leptospira grippotyphosa inact. Biocan DHPPi). it is recommended to revaccinate min. tre 32 defined by MAT*) DOSAGE yearly with Biocan LR vaccine. *) geometric mean of tres of specific anbodies defined by micro-agglunaon 1 ml subcutaneously regardless SHELF LIFE test of age, weight and breed 24 months. Use the vaccine TARGET SPECIES of the individual. immediately aer opening. Dogs. Vaccinaon scheme: STORAGE Primary vaccinaon at the age INDICATION Store in a dark and dry place of 8 weeks. For acve immunisaon of dogs at 2 °C – 8 °C. The vaccine must If necessary, it is possible to against rabies and leptospira not get frozen! vaccinate puppies at the age from serovars contained in vaccine. 8 weeks with Biocan L or PACKAGE INTERACTION WITH OTHER Biocan LR vaccine (in case of 10 × 1 ml, 20 × 1 ml, 50 × 1 ml, MEDICINAL PRODUCTS AND rabies in the area). Revaccinaon 100 × 1 ml. OTHER FORMS OF in this case is performed at INTERACTION the age of 12 weeks using Biocan Biocan LR vaccine may be used LR vaccine. To maintain separately, simultaneously or in permanent immunity against combinaon with other Biocan leptospira and rabies, it is vaccines: recommended to revaccinate yearly with Biocan LR vaccine.

20 1 Canine vaccines

Unique vaccine for prophylaxis and treatment of the dermatophytosis in dogs and cats

Biocan M inj. ad us. vet. Vaccine against Microsporum canis in dogs and cats

COMPOSITION DOSAGE SHELF LIFE Acve substance: 1 ml regardless of age, weight 24 months Microsporum canis inact. or bread of the animal. STORAGE min. 500 000 vegetave forms Dogs: strictly intramuscularly into Keep in a dry and dark place TARGET SPECIES the hind limb muscle. at 2 °C – 8 °C. Do not freeze. Dog, cat. Cats: subcutaneously into the area behind the blade bone PACKAGE INDICATION or intramuscularly into the hind 2 × 1 ml, 10 × 1 ml, 20 × 1 ml, From the 12th week of age for limb muscle. 50 × 1 ml, 100 × 1 ml. the prophylaxis and therapy of Preferably vaccinate into the le dermal mycosis in dogs and cats and revaccinate into the right half caused by the dermatophyte of the body. Microsporum canis. INTERACTION WITH OTHER MEDICINAL PRODUCTS AND OTHER FORMS OF INTERACTION Always apply Biocan M separately (never use it as a diluent for lyophilized vaccines or mix with liquid Biocan vaccines). Any other Biocan vaccine (Puppy, P, DP, DH, DHP, DHPPi, L, R, LR, C) can be administered simultaneously with Biocan M into a diﬀerent site (preferably on the other side).

21 1 Canine vaccines

Inacvated non-adjuvant vaccine against Microsporum canis infecon in dogs

Biocan M Plus injecon suspension for dogs Inacvated vaccine against Microsporum canis in dogs

COMPOSITION DOSAGE SHELF LIFE Acve substance: One ml of the vaccine can be 18 months Microsporum canis inact. applied to animals aged two STORAGE min. 1 million of vegetave forms months and above, regardless Store in a refrigerator TARGET SPECIES of the age, weight and race (2 oC – 8 oC). Do not freeze. Dogs. of the individual Protect from light Applicaon: deep intramuscularly INDICATION into the musculature of the pelvis PACKAGE For the prevenon and therapy extremity. 2 × 1 ml,10 × 1 ml, 20 × 1 ml, of dermal mycoses in dogs The vaccinaon should be carried 50 × 1 ml, 100 × 1 ml. induced by the dermatophyte out into the le body side and Microsporum canis. Animals the revaccinaon into the right should be vaccinated at the age body side.Prevenve and of 2 months and above. therapeuc use: animals shall be The immunity develops within vaccinated twice at the interval 1 month aer revaccinaon and of 10–21 days between the ﬁrst persists for at least 1 year. and the second vaccinaon. INTERACTION WITH OTHER The third vaccinaon dose MEDICINAL PRODUCTS AND can be applied, if necessary OTHER FORMS OF for therapeuc purposes, INTERACTION 10–21 days aer the Other immunoprophylacc revaccinaon. intervenons should not be carried out during one week before the ﬁrst vaccinaon up to 14 days aer the second (or, if relevant, the third) vaccinaon (except of the cases when the vaccine BIOCAN series is applied).

22 1 Canine vaccines

Monovalent protecon against canine parvovirosis in special situaon

Biocan P inj. sicc. ad us. vet. Live vaccine against parvovirosis (CPV-2) in dogs

COMPOSITION DOSAGE PACKAGE Freeze – dried component: The dose is 1 ml regardless of 5 × 1 ml of vaccine Biocan P + Acve substance: age, weight and breed of the 5 × 1 ml of diluent Parvovirus enteridis canis individual, vaccinaon may be 10 × 1 ml of vaccine Biocan P + 5.0 6.2 min. 10 TCID50, max.10 TCID50 ﬁrst performed during the sixth 10 × 1 ml of diluent Auxiliary substances: week of age. 50 × 1 ml of vaccine Biocan P + Nutrimentum pro lyophilisaone Method of administraon – 50 × 1 ml of diluent ad 1 ml subcutaneously, preferably in Diluent zone behind the shoulder-blade. Aqua pro injecone SHELF LIFE 1 ml 24 months, when diluted, TARGET SPECIES the vaccine shall be used Dogs. immediately. INDICATION STORAGE For the acve immunizaon Store in a dry and dark place at of dogs against parvovirosis. the temperature of 2 °C – 8 °C. INTERACTION WITH OTHER MEDICINAL PRODUCTS AND OTHER FORMS OF INTERACTION The vaccine Biocan P can be used separately or simultaneously with other vaccines Biocan according to recommended vaccinaon scheme or in group with ﬂuid vaccines Biocan (LR, L, C, R).

23 1 Canine vaccines

Safe vaccine for the vaccinaon of the youngiest puppies at 5th weeks of age

Biocan Puppy lyophilisate for the preparaon of injecon suspension with diluent Live vaccine against canine distemper and inacvated vaccine against canine parvovirosis

COMPOSITION within an interval of 14–21 days. 50 × 1 ml of lyophilised Lyophilized component (D) Yearly revaccinaon is component of the vaccine Virus febris contagiosae canis recommended in order to Biocan Puppy (Component D) 4,2 5,0 min. 10 TCID50 – max 10 TCID50 maintain a permanent immunity. 50 × 1 ml of liquid component Liquid component (P) SHELF LIFE of the vaccine Biocan Puppy Parvovirus enteridis canis inact. 24 month, use the vaccine (Component P) min. 1024 HAU – max 4096 HAU immediately aer reconstuon. TARGET SPECIES STORAGE Dogs. Store in a dry and dark place INDICATION at 2 oC – 8 oC. The vaccine must For an acve immunisaon of not get frozen! dogs against canine distemper and parvovirosis from 5th week PACKAGE of age. 5 × 1 ml of lyophilised component of the vaccine DOSAGE Biocan Puppy (Component D) Dose - 1 ml of injecon soluon, 5 × 1 ml of liquid component which is prepared by dilung of the vaccine Biocan Puppy the lyophilised component with (Component P) liquid component of the vaccine, 10 × 1 ml of lyophilised regardless of age, weight and component of the vaccine breed of the animal, but at the Biocan Puppy (Component D) earliest in the ﬁh week of age. 10 × 1 ml of liquid component Method of administraon – of the vaccine Biocan Puppy subcutaneous, best to the region (Component P) behind scapula. Individuals vaccinated for the ﬁrst me need to be revaccinated

24 1 Canine vaccines

Monovalent vaccine with immunogenic rabies virus SAD Vnukovo – 32

Biocan R suspension for injecon Inacvated vaccine against rabies

COMPOSITION DOSAGE recommended to revaccinate Acve ingredient Dosage – 1 ml regardless of age, in accordance with veterinary Virus rabiei inacvatum, weight and breed of the regulaons of each country. strain SAD Vnukovo – 32 individual; but at the earliest SHELF LIFE min. 2 IU in the 12th week of age. 24 months, to be used within TARGET SPECIES Method of administraon: 8 hours aer the first opening. - subcutaneous, best in Dogs, cats, fur animals, cale, STORAGE horses, sheep, goats, pigs. the region behind the shoulder blade. Store in a dry and dark place INDICATION - intramuscular, best to the at a temperature 2 °C – 8 °C. For acve immunisaon of target muscle of the rear limb. Do not freeze! animal species against rabies. Animals are vaccinated from PACKAGE INTERACTION WITH OTHER the age of 3 months. The onset of 10 × 1 ml, 20 × 1 ml, 50 × 1, MEDICINAL PRODUCTS AND protecve immunity is within 100 × 1 ml, 1 × 5 ml, 5 × 5 ml, OTHER FORMS OF 14 days aer immunisaon. 10 × 5 ml, 1 × 10 ml, 5 × 10 ml, INTERACTION Animals vaccinated earlier than 10 × 10 ml, 1 × 20 ml, 5 × 20 ml, Biocan R vaccine may be used at the age of 3 months must be 10 × 20 ml separately, simultaneously or revaccinated aer reaching this in combinaon with other age (minimal 14 day interval Biocan vaccines: between vaccinaons must be A/ Biocan R vaccine may be used observed). Animals vaccinated as a diluent for other lyophilised for the first me, at the age Biocan vaccines (for example of 3–12 months, must be DHPPi, DP, P). revaccinated in 1 year aer the B/ Biocan R vaccine may be first applicaon of the vaccine. administered simultaneously or Revaccinaon performed one with liquid vaccines Biocan C, year aer the first vaccine Biocan B, Biocan M and Biocan L. protects animals against rabies for at least 2 years. In order to maintain immunity, it is

25 1 Canine vaccines

Toxoid vaccine containing toxoid of Clostridium tetani for acve protecon against neurological symptoms of disease

Biocan T injecon suspension for dogs Vaccine against tetanus in dogs

COMPOSITION METHOD OF ADMINISTRATION PACKAGE Composion – 1 ml: Intramuscularly. 2 × 1 ml, 5 × 1 ml, 10 × 1 ml, Acve substance SHELF LIFE 20 × 1 ml, 1 × 2 ml. Anatoxinum tetanicum 36 months, usable life aer puriﬁcatum min. 7.5 IU the ﬁrst opening is max. 10 hours. TARGET SPECIES STORAGE Dogs. Store in a dry and dark place INDICATION at a temperature between Acve immunizaon of dogs 2 °C – 8 °C. Shake well the vial against tetanus. content before use. DOSAGE AND METHOD OF ADMINISTRATION 2 × 1 ml at the interval of 3 weeks (animals at the age of 3 months and above).

26 1 Canine vaccines

New vaccine protected against all the most pathogenic serogroups of Borrelia spp.

Borrelym 3 injecon suspension for dogs Vaccine against Lyme disease

COMPOSITION Onset of immunity: 1 month STORAGE Composion of one dose (1 ml): aer primary vaccinaon. Protect from light. Store Acve substances: Duraon of immunity: one year and transport at 2 °C – 8 °C. Inacvated Borrelia burgdorferi aer primary vaccinaon. STORAGE sensu lato: DOSAGE 10 × 1 ml, 2 × 1 ml, 20 × 1 ml, Borrelia garinii RP  1* 1 ml from 12 weeks of age. 50 × 1 ml, 100 × 1 ml. Borrelia afzelii RP  1* Subcutaneously. Shake the vial Borrelia burgdorferi sensu stricto well before use. RP  1* Primary vaccinaon: *RP = Relave potency (ELISA test) Administer two doses separated compared with the reference serum obtained aer vaccinaon of mice with a by an interval of 3 weeks. vaccine batch that has successfully passed Revaccinaon: the challenge test in the target species. Annual revaccinaon with a Suspension for injecon. single dose is recommended Pinkish up to white ﬂuid to maintain immunity although containing white sediment that this schedule has not been disperses easily when the content invesgated. is shaken. Vaccinaon should be carried out TARGET SPECIES prior to periods of increased ck Dogs. acvity, allowing suﬃcient me INDICATION for the immune response to For acve immunizaon of dogs vaccinaon to develop fully from 12 weeks of age, to induce prior to expected ck exposure. an an-OspA response against SHELF LIFE Borrelia spp. (B. burgdorferi sensu 24 months. stricto, B. garinii and B. afzelii).

27 1 Canine vaccines

Live vaccine containing new highly immunogenic parvo strain CPV 2b

Biocan NOVEL DHPPi lyophilisate and solvent for suspension for injecon for dogs

COMPOSITION  3 weeks aer compleon of the given with compable product Biocan Freeze-dried fracon (live primary course for CPiV Novel DHPPi/L4 and the vaccinaon aenuated): Duraon of immunity: scheme planned accordingly (please Canine Distemper virus, At least three years following the refer to SPC for Biocan Novel strain CDV Bio 11/A DHPPi/L4). 3.1 primary vaccinaon course for canine min. 10 TCID50 max. 105.1 TCID50 distemper virus, canine adenovirus Revaccinaon scheme: Canine Adenovirus Type 2, type 1, canine adenovirus type 2 and A single dose of Biocan Novel DHPPi strain CAV-2-Bio 13 3.6 canine parvovirus. At least one year should be given every 3 years. Annual min. 10 TCID50 max. 105.3 TCID50 following the primary vaccinaon re-vaccinaon is required for Canine Parvovirus Type 2b, course for canine parainfluenza virus. Parainfluenza, therefore a single dose strain CPV-2b-Bio 12/B 4.3 The duraon of immunity against of Biocan Novel DHPPi or Biocan min. 10 TCID50 max. 106.6 TCID50 CAV-2 was not established by Novel Pi/L4 can be used annually if Canine Parainfluenza virus, challenge. required. Full protecve immunity strain CPiV-Bio 15 3.1 5.1 It was shown that 3 years aer the against leptospira component of the min. 10 TCID50 max. 10 TCID50 vaccinaon CAV-2 anbodies are sll Pi/L4 vaccine, if used for annual INDICATION present. Protecve immune response revaccinaon, is formed only aer the Acve immunizaon of dogs from against CAV-2 associated respiratory basic vaccinaon with a Biocan Novel 6 weeks of age. disease is considered to last at least vaccine containing the L4 component. to prevent mortality and clinical signs 3 years. SHELF LIFE caused by canine distemper virus DOSAGE AND METHOD OF 24 months, aer reconstuon to prevent mortality and clinical signs ADMINISTRATION according to direcons: administer the caused by canine adenovirus type 1 Subcutaneous use. vaccine immediately. to prevent clinical signs and reduce viral excreon caused by canine Dose and route of administraon: STORAGE adenovirus type 2 Asepcally reconstute the Store and transport refrigerated to prevent clinical signs, leukopenia lyophilisate with the solvent. Shake (2 °C – 8 °C). Do not freeze and viral excreon caused by canine well and administer immediately the PACKAGE to prevent clinical signs (nasal and enre content (1 ml) of the 10 × 1 dose, 25 × 1 dose. ocular discharge) and reduce viral reconstuted product. excreon caused by canine Basic vaccinaon scheme: parainfluenza virus Two doses of Biocan Novel DHPPi Onset of immunity: apart 3–4 weeks apart from 6 weeks  3 weeks aer the first vaccinaon of age. for CDV, CAV, CPV, If protecon against leptospira is required the second dose may be 28 1 Canine vaccines

Combined vaccine containing four the most common and highly pathogenic serovars of Leptospira spp. in diluent fracon

Biocan NOVEL DHPPi/L4 lyophilisate and solvent for suspension for injecon for dogs

COMPOSITION to prevent mortality and clinical signs Primary vaccinaon scheme: Freeze-dried fracon (live caused by canine adenovirus type 1 Two doses of Biocan Novel DHPPi/L4 aenuated): to prevent clinical signs and reduce 3–4 weeks apart from 6 weeks of age. Canine Distemper virus, viral excreon caused by canine Rabies: strain CDV Bio 11/A, adenovirus type 2 3.1 5.1 If protecon against rabies is required: min. 10 max. TCID50 10 TCID50 to prevent clinical signs, leukopenia Canine Adenovirus Type 2, and viral excreon caused by canine First dose: Biocan Novel DHPPi/L4 strain CAV-2-Bio 13, parvovirus from 8–9 weeks of age. 3.6 5.3 Second dose: Biocan Novel DHPPi/L4R min. 10 TCID50 max. 10 TCID50 to prevent clinical signs (nasal and Canine Parvovirus Type 2b, ocular discharge) and reduce viral 3–4 weeks later, but not before strain CPV-2b-Bio 12/B, excreon caused by canine 12 weeks of age. 4.3 6.6 In case of need, dogs younger than min. 10 TCID50 max. 10 TCID50 parainfluenza virus Canine Parainfluenza virus, to prevent clinical signs, infecon and 8 weeks can be vaccinated as safety strain CPiV-Bio 15, urinary excreon caused by of Biocan Novel DHPPi/L4R has been 3.1 5.1 demonstrated in 6 weeks old dogs. min. 10 TCID50 max. 10 TCID50 L. interrogans serogroup Australis Liquid fracon (inacvated): serovar Braslava Revaccinaon scheme: Leptospira interrogans, serogroup to prevent clinical signs and urinary A single dose of Biocan Novel Icterohaemorrhagiae, excreon and reduce infecon caused DHPPi/L4 should be given every serovar Icterohaemorrhagiae, strain by L. interrogans serogroup Canicola 3 years. Annual re-vaccinaon is MSLB 1089 GMT ≥ 1:51 ALR serovar Canicola and L. interrogans required for Parainfluenza and Leptospira interrogans, serogroup serogroup Icterhaemorrhagiae serovar Leptospira components, therefore Canicola, serovar Canicola, strain Icterohaemorrhagiae a single dose of compable vaccine MSLB 1090 GMT ≥ 1:51 ALR to prevent clinical signs and reduce Biocan Novel Pi/L4 can be used Leptospira kirschneri, serogroup infecon and urinary excreon caused annually as required. Grippotyphosa, serovar by L. kirschneri serogroup SHELF LIFE Grippotyphosa, strain MSLB 1091 Grippotyphosa serovar Grippotyphosa 24 months, aer reconstuon GMT ≥ 1:40 ALR DOSAGE AND METHOD OF according to direcons: administer Leptospira interrogans, serogroup ADMINISTRATION the vaccine immediately. Australis, serovar Braslava, strain Subcutaneous use. STORAGE MSLB 1088 GMT ≥ 1:51 Dose and route of administraon: Store and transport refrigerated INDICATION Asepcally reconstute the (2 °C – 8 °C). Do not freeze. Acve immunizaon of dogs lyophilisate with the solvent. Shake PACKAGE from 6 weeks of age: well and administer immediately the 10 × 1 dose, 25 × 1 dose. to prevent mortality and clinical signs enre content (1 ml) of the caused by canine distemper virus reconstuted product.

29 1 Canine vaccines

Polyvalent vaccine intended for the last revaccinaon of puppies and boostering adult dogs

Biocan NOVEL DHPPi/L4R lyophilisate and solvent for suspension for injecon for dogs

COMPOSITION to prevent clinical signs and reduce reconstute the lyophilisate with the Freeze-dried fracon (live viral excreon caused by canine solvent. Shake well and administer aenuated): Canine Distemper virus, adenovirus type 2, to prevent clinical immediately the enre content (1 ml) 3.1 strain CDV Bio 11/A – min. 10 TCID50 signs, leukopenia and viral excreon of the reconstuted product. 5.1 max. 10 TCID50, Canine Adenovirus caused by canine parvovirus Basic vaccinaon scheme: 3.6 Type 2, strain CAV-2-Bio 13 – min. 10 to prevent clinical signs (nasal and Two doses of Biocan Novel DHPPi/L4R 5.3 TCID50 max. 10 TCID50, Canine ocular discharge) and reduce viral 3–4 weeks apart from 8–9 weeks of Parvovirus Type 2b, strain CPV-2b-Bio excreon caused by canine age. The second dose should not be 4.3 6.6 12/B – min. 10 TCID50 max. 10 parainfluenza virus, to prevent clinical given before 12 weeks of age. TCID50, Canine Parainfluenza virus, signs, infecon and urinary excreon 3.1 50 Rabies strain CPiV-Bio 15 – min. 10 TCID caused by L. interrogans serogroup 50 In case of need, dogs younger than max. 10 TCID Australis serovar Braslava 5.1 8 weeks can be vaccinated as safety of Liquid fracon (inacvated): to prevent clinical signs and urinary this product has been demonstrated Leptospira interrogans, serogroup excreon and reduce infecon caused in 6 weeks old dogs. The vaccinaon Icterohaemorrhagiae, serovar by L. interrogans serogroup Canicola may be indicated as soon as 6 weeks Icterohaemorrhagiae, strain serovar Canicola and L. interrogans of age with compable product Biocan MSLB 1089 GMT ≥ 1:51 ALR serogroup Icterohaemorrhagiae Novel DHPPi. Leptospira interrogans, serogroup serovar Icterohaemorrhagiae Canicola, serovar Canicola, strain to prevent clinical signs and reduce Revaccinaon scheme: MSLB 1090 GMT ≥ 1:51 ALR infecon and urinary excreon caused A single dose of Biocan Novel DHPPi/ Leptospira kirschneri, serogroup by L. kirschneri serogroup L4R should be given every 3 years. Grippotyphosa, serovar Grippotyphosa serovar Grippotyphosa Annual re-vaccinaon is required for Grippotyphosa, strain MSLB 1091 to prevent mortality, clinical signs and Parainfluenza and Leptospira GMT ≥ 1:40 ALR infecon caused by rabies virus components therefore a single dose of compable vaccine Biocan Novel Pi/L4 Leptospira interrogans, serogroup Duraon of immunity: can be used annually as required. Australis, serovar Braslava, strain At least three years following the MSLB 1088 GMT ≥ 1:51 primary vaccinaon course for canine SHELF LIFE Inacvated rabies virus, strain SAD distemper virus, canine adenovirus 24 months, aer reconstuon Vnukovo-32 > 2.0 IU type 1, canine adenovirus type 2, according to direcons: administer the vaccine immediately. INDICATION canine parvovirus and rabies. At least Acve immunizaon of dogs from one year following the primary STORAGE 8–9 weeks of age: vaccinaon course for canine Store and transport refrigerated to prevent mortality and clinical signs parainfluenza virus, Leptospira (2 °C – 8 °C).Do not freeze. Protect caused by canine distemper virus components. from light. to prevent mortality and clinical signs DOSAGE PACKAGE caused by canine adenovirus type 1 Subcutaneous use. Asepcally 10 × 1 dose, 25 × 1 dose.

30 1 Canine vaccines

Vaccine intended for yearly revaccinaon against parainﬂuenza and leptospirosis

Biocan NOVEL Pi/L4 lyophilisate and solvent for suspension for injecon for dogs

COMPOSITION Lyophilisate: Spongy maer of DOSAGE Freeze-dried fracon (live white colour. Reconstute one vial of the aenuated): Solvent: Whish colour with lyophilisate asepcally using the Canine Parainfluenza virus, strain easily shakeable sediments. contents of one vial of the 3.1 CPiV-Bio 15 min 10 TCID50 Reconstuted vaccine:Pinkish or solvent. Shake well and 5.1 max. 10 TCID50 yellowish colour with light immediately inject the enre Liquid fracon (inacvated): opalescence. content of the reconstuted vial Leptospira interrogans, serogroup INDICATION (1 ml) subcutaneously. Do not use Icterohaemorrhagiae, Acve immunizaon of dogs from chemically sterilised syringes or serovar Icterohaemorrhagiae, six weeks of age. needles, as these may interfere strain MSLB 1089 - to prevent clinical signs and with the effecveness of the GMT ≥ 1:51 ALR reduce viral excreon caused by vaccine. Leptospira interrogans, serogroup canine parainfluenza virus Basic vaccinaon scheme: Canicola, - to prevent clinical signs, Two doses of Biocan Novel Pi/L4 serovar Canicola, strain MSLB infecon and urinary excreon 3 – 4 weeks apart from 6 weeks 1090 caused by Leptospira serovars of age. GMT ≥ 1:51 ALR braslava, canicola, Revaccinaon scheme: Leptospira kirschneri, serogroup grippotyphosa and A single dose of Biocan Novel Grippotyphosa, icterohaemorrhagiae Pi/L4 to be given annually. serovar Grippotyphosa, strain Onset of immunity: SHELF LIFE MSLB 1091 Immunity has been 24 months, aer reconstuon GMT ≥ 1:40 ALR demonstrated from 3 weeks aer according to direcons: Leptospira interrogans, serogroup compleon of the primary course administer the vaccine Australis, for CPiV and from 4 weeks aer immediately. serovar Braslava, strain MSLB compleon of the primary course STORAGE 1088 for Leptospira components. GMT ≥ 1:51 Store and transport refrigerated Duraon of immunity: (2 °C – 8 °C). Do not freeze. Lyophilisate and solvent, for At least one year following the suspension for injecon. primary vaccinaon course for all PACKAGE The visual appearance is as components of Pi/L4. 10 × 1 dose, 25 × 1 dose. follows:

31 1 Canine vaccines

Combined puppy vaccine against distemper and parvovirosis, veriﬁed through challenges against three parvovirus strains CPV 2a, 2b, 2c, and against the CDV distemper virus

Biocan NOVEL Puppy lyophilisate and solvent for suspension for injecon for dogs

COMPOSITION Duraon of immunity: The Reconstuted vaccine: Clear One vaccinaon dose (1 ml) duraon of immunity against colourless to yellowish liquid with contains: CDV and CPV in puppies without light opalescence. Acve substances: maternally derived anbodies Basic vaccinaon scheme: Lyophilisate: Canine Distemper was aer a single dose of Biocan A single dose of Biocan Novel virus, strain CDV Bio 11/A, live Novel Puppy vaccine determined Puppy vaccine from 6 weeks of 4,1 aenuated 10 TCID50 – for 12 months. The duraon of age. 5,5 10 TCID50 immunity against CDV and CPV SHELF LIFE Canine Parvovirus type 2b, strain type 2b was demonstrated Shelf life of the veterinary CPV-2b Bio 12/B, live aenuated serologically and by challenge, 5,5 7,0 medicinal product as packaged 10 TCID50 – 10 TCID50 duraon of immunity against CPV for sale: 2 years. * Tissue culture infecous dose – 50% types 2a and 2c was Shelf life aer reconstuon Solvent: Water for injecon 1 ml demonstrated serologically. according to direcons: use TARGET SPECIES DOSAGE immediately. Dogs. Subcutaneous use. STORAGE INDICATION Dose and route of administraon: Store and transport refrigerated Acve immunizaon of dogs from Each dose is prepared by (2 °C – 8 °C). Protect from light. 6 weeks of age: reconstung the vial with Do not freeze. - to prevent mortality and clinical lyophilisate (component CDV and PACKAGE signs caused by canine distemper CPV) by vial of solvent (water for 5 × 1 dose, 10 × 1 dose, virus injecon). The reconstuted 25 × 1 dose. - to prevent clinical signs, vaccine should be gently shaken leukopenia and viral excreon and is intended for immediate caused by canine parvovirus type subcutaneous administraon. 2a, 2b and 2c Apply 1 ml regardless of the Onset of immunity: Immunity weight and breed of individual against CDV and CPV is from 6 weeks of age. developed within 14 days aer a single dose in puppies free of maternally derived anbodies.

32 1 Canine vaccines

Monovalent rabies vaccine containing me-tested strain SAD Vnukovo - 32

Biocan NOVEL R NOVELTY 2019

COMPOSITION DOSAGE Revaccinaon scheme: Liquid fracon (inacvated): 1 ml subcutaneously. Do not use A single dose of Biocan Novel R Inacvated rabies virus, strain chemically sterilised syringes or should be given every 3 years. SAD Vnukovo-32 ≥ 2.0 IU*** needles, as these may interfere SHELF LIFE Adjuvant: with the effecveness of the 24 months, aer reconstuon Aluminium hydroxide gel vaccine. Shake well before according to direcons: 1.8–2.2 mg administraon. administer the vaccine INDICATION Basic vaccinaon scheme: immediately. Acve immunizaon of dogs One dose of Biocan Novel R from from 12 weeks of age to prevent 12 weeks of age. SPECIAL STORAGE mortality, clinical signs and The efficacy is proven aer PRECAUTION infecon caused by rabies virus. a single dose from 12 weeks Store and transport refrigerated In case of need, dogs younger of age in laboratory studies. (2 °C – 8 °C). Do not freeze. than 12 weeks can be vaccinated. However, in field studies 10% of PACKAGE In this case the vaccine can be seronegave dogs did not show 10 × 1 dose, 25 × 1 dose. administered from 6 weeks of age seroconversion (> 0.1 IU/ml) in two doses. The second dose 3–4 weeks aer single primary should not be administered vaccinaon against rabies. before 12 weeks of age and not Another 17% did not show earlier than 3 weeks aer the first the 0.5 IU/ml rabies anbody dose. tre required by some non-EU Onset of immunity: countries to travel in. In case 2 weeks aer a single vaccinaon of travelling to risk areas or for from 12 weeks of age. travel outside the EU veterinary Duraon of immunity: surgeons may wish to use a two At least three years following the dose primary course including primary vaccinaon course. rabies or give an addional rabies Duraon of immunity was vaccinaon aer 12 weeks. demonstrated aer one vaccinaon at 12 weeks of age.

33 34 CATTLE VACCINES

BioBos BTV 1, 8 BioBos BTV 8 BioBos IBR marker inact. BioBos IBR marker live BioBos L BioBos L(6) BioBos Respi 2 intranasal BioBos Respi 3 BioBos Respi 4 KOLIBIN RC Neo MORAXEBIN Neo TRICHOBEN 2 TRICHOBEN AV 2 Cale vaccines

Vaccine against Blue tongue disease in cale and sheep

BioBos BTV 1, 8 injecon suspension for cale and sheep

COMPOSITION DOSAGE SHELF LIFE Acve substance: Dosage: 1 ml regardless of age, Shelf life of the veterinary Inacvated Bluetongue Virus weight and breed of the medicinal product in intact Serotype 1 min. 100 Elisa individual, but earliest in the 1st package 18 months and aer the units/ml, max. 1 000 Elisa month of animal age. ﬁrst opening of the immediate units/ml Applicaon: Subcutaneously. packaging 10 hours. Inacvated Bluetongue Virus Basic immunisaon for cale STORAGE Serotype 8 min. 100 Elisa (vaccinaon with subsequent Store in a refrigerator units/ml, max. 1 000 Elisa revaccinaon): (2 °C – 8 °C). units/ml 1st injecon: calves from the age The vaccine induces producon of 1 month (or from the age of PACKAGE of anbodies against infecon 3 months of the young ones from 1 × 10 ml, 1 × 50 ml, 10 × 10 ml, caused by virus Bluetongue vaccinated mothers) 1 × 100 ml in glass or plasc vials. (Bluetongue virus, BTV serotype 2nd injecon: 3 weeks later 1 and 8). Revaccinaon: TARGET SPECIES Annual revaccinaon with a Cale and sheep. single dose (1 ml) 2 weeks prior to the risky period. INDICATION Basic immunisaon for sheep Intended for acve immunizaon (vaccinaon with subsequent of cale and sheep from one revaccinaon): month of age to prevent viremia 1st injecon: sheep from the age and clinical signs of disease of 1 month (or from the age of caused by a virus Bluetongue 2.5 months of the young ones (Bluetongue virus, BTV serotype from the vaccinated mothers) 1 and 8). Revaccinaon: Annual revaccinaon with a single dose (1ml) 2 weeks prior to the risky period.

36 2 Cale vaccines

Vaccine against Blue tongue disease in cale and sheep

BioBos BTV 8 injecon suspension for cale and sheep

COMPOSITION Applicaon: Subcutaneously. SHELF LIFE Acve substance: Basic immunisaon for cale Shelf life of the veterinary Inacvated Bluetongue Virus (vaccinaon with subsequent medicinal product in intact 7,0 Serotype 8 min. 10 TCID50 revaccinaon): package 18 months and aer The vaccine induces producon 1st injecon: calves from the age the ﬁrst opening of the of anbodies against infecon of 1 month (or from the age of immediate packaging 10 hours. caused by virus Bluetongue 3 months of the young ones from STORAGE (Bluetongue virus, BTV 8). vaccinated mothers) Store in a refrigerator TARGET SPECIES 2nd injecon: 3 weeks later (2 °C – 8 °C). Cale and sheep. Revaccinaon: Annual revaccinaon with PACKAGE INDICATION a single dose (1 ml) 2 weeks prior 1 × 10 ml, 1 × 50 ml, 10 × 10 ml, Intended for acve immunizaon to the risky period. 1 × 100 ml, 1 × 250 ml in glass or of cale and sheep from one Basic immunisaon for sheep plasc vials. month of age to prevent viremia (vaccinaon with subsequent and clinical signs of disease revaccinaon): caused by a virus Bluetongue 1st injecon: sheep from the age (Bluetongue virus, of 1 month (or from the age of BTV serotype 8). 2.5 months of the young ones DOSAGE from the vaccinated mothers) Dosage: 1 ml regardless of age, Revaccinaon: weight and breed of the Annual revaccinaon with a individual, but earliest in the single dose (1ml) 2 weeks prior to 1st month of animal age. the risky period.

37 2 Cale vaccines

Marker vaccine against IBR (BHV-1) infecon inacvated

BioBos IBR marker inact. injecon suspension for cale

COMPOSITION DOSAGE, ROUTE OF STORAGE Acve substance: ADMINISTRATION AND Store in a refrigerator Bovine herpesvirus type 1 (BHV- VACCINATION SCHEME (2 °C – 8 °C). Do not freeze. 1) inacvated (strain Bio-27: Dosage: 2 ml PACKAGE IBR gE -) RP ≥ 1 Applicaon: intramuscularly. 10 ml, 50 ml, 100 ml in glass TARGET SPECIES Basic vaccinaon: or plasc bole. Cale from the age of 3 months. two applicaons in the 3-week interval. INDICATION Revaccinaon: For acve immunizaon of cale one applicaon every 6 months. to reduce intensity and term of the clinical symptoms caused by Onset of protecon 3 weeks aer infecon by the BHV-1 (IBR) virus the basic vaccinaon immunity and to reduce excreon of the persists 6 months aer the basic ﬁeld virus. vaccinaon. SHELF LIFE Shelf life of the veterinary medicinal product in intact package 2 years and aer the ﬁrst opening of the immediate packaging 10 hours.

38 2 Cale vaccines

Marker vaccine against IBR (BHV- 1) infecon live

BioBos IBR marker live lyophilizate and solvent for preparaon of suspension

COMPOSITION CHARACTERISTIC AND DOSAGE AND ROUTE OF Acve substance: INDICATION ADMINISTRATION Bovine herpesvirus type 1 (BHV- Marker vaccine against IBR 2 ml intranasal or intramuscularly 1) aenuated (strain Bio-27: IBR (BHV-1) live for the acve aer asepc preparaon of the 5.7 gE -) min. 10 TCID50; immunizaon of cale from vaccine. 7.5 max. 10 TCID50 2 weeks of age, to reduce the STORAGE TARGET SPECIES intensity and duraon of clinical Store in a refrigerator Cale. symptoms induced by viral (2 °C – 8 °C). Do not freeze. infecon caused by BHV-1 (IBR), and to decrease the excreon of PACKAGE ﬁeld virus. The onset of immunity 5 × 5 doses or 1 × 25 doses in was demonstrated 7 days aer glass vials with 10 ml or 50 ml intranasal vaccinaon and Diluent A. 14 days aer intramuscular vaccinaon of serologically negave animals. The vaccine does not induce the formaon of anbodies against IBR glycoprotein E (marker vaccine). Thereby cale vaccinated using this vaccine can be recognized from cale infected with IBR ﬁeld virus or vaccinated using convenonal non-marker vaccines against IBR virus.

39 2 Cale vaccines

Inacvated monovalent vaccine against Bovine Leptospirosis caused by Leptospira borgpetersenii serovar hardjo, type hardjo-bovis

BioBos L injecon suspension for cale

COMPOSITION DOSAGE, ROUTE OF Revaccinaon: Acve substance: ADMINISTRATION AND For the keeping of the protecve Leptospira hardjo type hardjo- VACCINATION SCHEME immunity an annual bovis inact. min. tre 32 Dosage: 2 ml revaccinaon by a single dose is determined by ALR* Applicaon: subcutaneously required at least 2 weeks before Basic vaccinaon: mang. * The value was determined on the basis of Onset imunity 4 weeks aer basic the tres of the reference serum obtained This requires administraon of from 5 rabbits vaccinated with a batch 2 vaccinaon doses with the vaccinaon scheme (aer two compliant with the challenge potency test on range of 4 – 6 weeks, whereas doses of vaccine) and duraon the target species (ALR = agglunaon-lyc of immunity 12 months. reacon). the second dose must be administered at least 4 weeks SHELF LIFE TARGET SPECIES before mang. The main effect is Shelf life of the veterinary Cale. the prevenon of excreon of medicinal product in intact INDICATION leptospiras by urine. If the second package 2 years and aer the first For acve immunizaon of cale vaccinaon dose is administered opening of the immediate since 4 weeks of age against at least 2 weeks before mang packaging 10 hours. leptospirosis (serovar hardjo, typ. the significant prevenon of the STORAGE hardjo-bovis) to prevent foetus also occurs. Store in a refrigerator infecon, protecon of embryos The calves may be vaccinated (2 °C – 8 °C). Do not freeze. and foetuses and excreon of from 4 weeks of age, the basic PACKAGE leptospiras especially by urine. vaccinaon requires the administraon of 2 vaccinaon 4 ml, 10 ml, 20 ml, 50 ml, 100 ml, doses. At reaching the category 250 ml in glass or plasc HDPE of the heifer the vaccinaon is bole. accomplished once before mang.

40 2 Cale vaccines

Inacvated polyvalent vaccine against Bovine Leptospirosis caused by major dangerous 6 serovars

BioBos L(6) injecon suspension for cale

COMPOSITION INDICATION doses. At reaching the category Acve substance: For acve immunisaon of cale of the heifer the vaccinaon is Leptospira pomona inact. from 4 weeks of age against accomplished once before min. tre 16 determined by ALR* leptospirosis (6 serovars mang. Leptospira hardjo type hardjo- contained in the vaccine) to Revaccinaon: prajitno inact. min. tre 35 prevent infecon, foetal infecon For the keeping of the protecve determined by ALR* and eliminaon of leptospires immunity an annual Leptospira hardjo type hardjo- especially in urine. revaccinaon by a single dose is bovis inact. min. tre 32 DOSAGE, ROUTE OF required at least 2 weeks before determined by ALR* ADMINISTRATION AND mang. Leptospira grippotyphosa inact. VACCINATION SCHEME Onset imunity 4 weeks aer basic min. tre 64 determined by ALR* Dosage: 2 ml vaccinaon scheme ( aer two Leptospira icterohaemorrhagiae Applicaon: subcutaneously doses of vaccine) and duraon inact. min. tre 81 determined by of immunity 12 months. ALR* Basic vaccinaon: This requires administraon of SHELF LIFE Leptospira canicola inact. Shelf life of the veterinary min. tre 35 determined by ALR* 2 vaccinaon doses with the range of 4 – 6 weeks, whereas medicinal product in intact package 2 years and aer the * The values were determined on the basis the second dose must be of the tres of the reference serum obtained administered at least 4 weeks first opening of the immediate from 5 rabbits vaccinated with a batch before mang. The main effect is packaging 10 hours. compliant with the challenge potency test on the target species (ALR = agglunaon-lyc the prevenon of excreon of STORAGE reacon). leptospiras by urine. If the second Store in a refrigerator vaccinaon dose is administered (2 °C – 8 °C). Do not freeze. TARGET SPECIES at least 2 weeks before mang Cale. PACKAGE the significant prevenon of the 10 ml, 50 ml, 100 ml in glass foetus also occurs. or plasc boles. The calves may be vaccinated from 4 weeks of age, the basic vaccinaon requires the administraon of 2 vaccinaon

41 2 Cale vaccines

Intranasal live vaccine against major viral pathogens of Bovine Respiratory Disease Complex (BRDC) caused by Bovine respiratory syncyal virus and Parainﬂuenza 3 virus

BioBos Respi 2 intranasal lyophilisate and solvent for nasal suspension

COMPOSITION DOSAGE, ROUTE OF STORAGE Acve substance: ADMINISTRATION AND Store in a refrigerator Bovine parainfluenza 3 (PI3), VACCINATION SCHEME (2 °C – 8 °C). Do not freeze. modified live virus, strain Bio Dosage: 2 ml Protect from direct sunlight. 5.0 7.5 23/A 10 – 10 TCID50 Applicaon: intranasally PACKAGE Bovine respiratory syncyal virus Administer one dose (2 ml) of the Printed carton: 1 × 5 doses (BRSV), modified, live, strain Bio 4.0 6.0 diluted vaccine intranasally to (1 × 3 ml of lyophilised vaccine + 24/A 10 – 10 TCID50 calves from 10 days of age using 1×10 ml of Diluent A). TCID50 – a 50% infecous dose for ssue an special intranasal applicator. Plasc box with a lid, cultures It is recommended to use a new with 10 wells: 5 × 5 doses applicator for each animal, in (5 × 3 ml of lyophilised vaccine + TARGET SPECIES order to prevent the transmission 5 × 10 ml of Diluent A). Intranasal Cale from the age of 10 days of infecon. applicator (box with 5 pieces) is INDICATION The onset of immunity has been not part of the packaging. For the acve immunizaon of demonstrated 10 days aer Aplicators are distributed calves from the age of 10 days a single vaccinaon. The duraon together with the vaccine. against BRSV and PI3V, to reduce of immunity aer single dose is the amount and duraon of 12 weeks. Immunity has been excreon of both these viruses. demonstrated by vaccinaon of serologically negave animals. SHELF LIFE Shelf life of the veterinary medicinal product in intact package (lyophilisate) 2 years and solvent as packaged for sale 4 years. Shelf life aer diluon according to direcons: 2 hours.

42 2 Cale vaccines

Inacvated vaccine against Bovine Respiratory Disease Complex (BRDC) caused by Bovine respiratory syncyal virus, Parainﬂuenza 3 virus and bacteria Mannheimia (Pasteurella) haemolyca

BioBos Respi 3 injecon suspension for cale

COMPOSITION DOSAGE, ROUTE OF Anbody response against BRS Acve substance: ADMINISTRATION AND virus, PI 3 virus and Mannheimia Virus respiratoris syncyalis VACCINATION SCHEME haemolyca reaches the highest bovis inacvatum, Dosage: 2 ml level in 3 weeks aer full strain Bio-24 RP ≥ 1* Applicaon: subcutaneously immunisaon programme. Virus parainfluensis 3 Basic immunisaon (vaccinaon Another revaccinaon is bovis inacvatum, with subsequent revaccinaon): recommended as required within strain Bio-23 RP ≥ 1* Vaccinaon of calves is an interval of 6 months aer Mannheimia (Pasteurella) recommended from 8 weeks performance of the basic haemolyca inacvata, strain of age with revaccinaon in immunisaon, because immunity DSM 5283, serovar 1A RP ≥ 1* 2–4 weeks (it is possible to persists aer revaccinaon *) Relave efficiency (RP) is given by the vaccinate calves from the age for at least 6 months. comparison of the anbody levels in serum of 2 weeks). SHELF LIFE prepared with the reference vaccine batch complying with the challenge test in target Revaccinaon: Shelf life of the veterinary animals. In problemac breeds, another medicinal product in intact package 2 years and aer the first TARGET SPECIES revaccinaon is recommended opening of the immediate Cale from the age of 2 weeks. within a period of 6 months aer basic immunisaon, possibly packaging 10 hours. INDICATION before risky period in parcular STORAGE For acve immunisaon of cale breed (e.g. transfer of animals, Store in a refrigerator against Parainfluenza 3 virus to change of the stabling system, (2 °C – 8 °C). Do not freeze. reduce infecon, Bovine etc.). respiratory syncyal virus to PACKAGE Pregnant cows and heifers: reduce infecon and clinical 2 ml, 10 ml, 20 ml, 50 ml, Vaccinaon with subsequent symptoms, and bacteria 100 ml in glass bole. revaccinaon within 7–5 weeks Mannheimia (Pasteurella) and 4–2 weeks before expected haemolyca serotype A1 to date of labour due to increased reduce clinical symptoms and resistance of the offspring via pulmonary lesions. colostrum.

43 2 Cale vaccines

Inacvated vaccine against Bovine Respiratory Disease Complex (BRDC) caused by Bovine respiratory syncyal virus, Parainﬂuenza 3 virus, Bovine viral diarrhoea virus and bacteria Mannheimia (Pasteurella) haemolyca

BioBos Respi 4 injecon suspension for cale

COMPOSITION symptoms, Bovine viral diarrhoea Pregnant cows and heifers: Acve substance: virus to reduce infecon, and Vaccinaon with subsequent Virus respiratoris syncyalis bacteria Mannheimia revaccinaon within 7 – 5 weeks bovis inacvatum, (Pasteurella) haemolyca and 4 – 2 weeks before expected strain BIO-24 RP  1 serotype A1 to reduce clinical date of labour due to increased Virus parainfluensis 3 bovis symptoms and pulmonary resistance of the offspring via inacvatum, lesions. colostrum. strain BIO-23 RP  1 DOSAGE, ROUTE OF Anbody response against BRS Virus diarrhoeae bovis ADMINISTRATION AND virus, PI 3 virus, BVD virus and inacvatum, VACCINATION SCHEME Mannheimia haemolyca reaches strain BIO-25 RP  1 Dosage: 2 ml the highest level in 3 weeks aer Mannheimia (Pasteurella) Applicaon: subcutaneously full immunisaon programme. haemolyca inacvata, Another revaccinaon is Basic immunisaon (vaccinaon strain DSM 5283, recommended as required within with subsequent revaccinaon): serovar 1A RP  1 an interval of 6 months aer Vaccinaon of calves is performance of the basic The vaccine induces producon recommended from 8 weeks immunisaon, because immunity of anbodies against infecon of age with revaccinaon persists for at least 6 months. caused by Bovine respiratory in 2–4 weeks (it is possible to synal virus, Parainfluenza 3 vaccinate calves from the age SHELF LIFE virus, Bovine viral diarrhoea virus of 2 weeks). Shelf life of the veterinary and bacteria Mannheimia medicinal product in intact Revaccinaon: (Pasteurella) haemolyca. package 2 years and aer the In problemac breeds, another first opening of the immediate TARGET SPECIES revaccinaon is recommended packaging 10 hours. Cale from the age of 2 weeks. within a period of 6 months aer STORAGE INDICATION basic immunisaon, possibly Store in a refrigerator For acve immunisaon of cale before risky period in parcular (2 °C – 8 °C). Do not freeze. against Parainfluenza 3 virus to breed (e.g. transfer of animals, reduce infecon, Bovine change of the stabling system, PACKAGE respiratory syncyal virus to etc.). 2 ml, 10 ml, 20 ml, 50 ml, 100 ml reduce infecon and clinical in glass bole. 44 2 Cale vaccines

Inacvated vaccine against Rotavirosis, Coronavirosis and E. coli infecons of calves

KOLIBIN RC Neo injecon suspension for cale

COMPOSITION DOSAGE, ROUTE OF lactogenic immunity for the first Acve substance: ADMINISTRATION AND 2–4 weeks of life. Rotavirus bovinum, VACCINATION SCHEME Feeding with colostrum: strain TM-91, inact. RP  1 Dosage: 2 ml In order to ensure the effecve Coronavirus bovinum, Applicaon: intramuscularly, prevenon of calves against strain C-197, inact. RP  1 preferably into the muscles in infecon, the gastrointesnal E. coli – 3 serovars of inacvated gluteal region tract of calves shall be saturated enteropathogenic strains – The pregnant heifers (or sll with colostrum obtained from O8:K35, K99; O9:K35, K99; unvaccinated cows) are the vaccinated cows for the first O101:K30, K99 RP  1 vaccinated twice at the interval 2–3 weeks of their life. A calf shall drink the adequate Vaccinaon of pregnant heifers of 21 days, namely, 7–5 weeks colostrum volume obtained from and cows induces formaon of and 4–2 weeks before the first the vaccinated cows within the specific colostral anbodies expected calving. 6 hours aer its birth. against both the viral and The next vaccinaons are bacterial angens contained in performed once, namely, before SHELF LIFE the vaccine. each next calving. Shelf life of the veterinary medicinal product in intact TARGET SPECIES Onset of immunity in calves fed package 2 years and aer the first Cale (pregnant heifers and from mothers , and in calves fed opening of the immediate cows). with colostrum collected from the vaccinated cows, the passive packaging 10 hours. INDICATION protecon starts when feeding STORAGE Acve immunisaon of pregnant begins. Duraon of imunity Store in a refrigerator heifers and cows for the purpose in calves fed with colostrum (2 °C – 8 °C). Do not freeze. of passive immunisaon of calves collected from the vaccinated against gastro-enteric diseases PACKAGE cows, their passive protecon caused by rotavirus, coronavirus 2 ml, 4 ml, 10 ml, 20 ml, 50 ml, against infecon lasts unl and enteropathogenic E. coli 100 ml, 250 ml in glass bole. feeding with colostrum is strains. interrupted. The calves fed from mothers are protected against the infecon by colostral and

45 2 Cale vaccines

Inacvated vaccine against Infecous bovine keratoconjuncvis caused by Moraxella bovis

MORAXEBIN Neo injecon suspension for cale

COMPOSITION DOSAGE, ROUTE OF SHELF LIFE Acve substance: ADMINISTRATION AND Shelf life of the veterinary Moraxella bovis inacvata – at VACCINATION SCHEME medicinal product in intact least 2.5 × 1010 CFU Dosage: 2 ml package 18 months and aer TARGET SPECIES Applicaon: intramuscularly the ﬁrst opening 10 hours. Cale. 2× at an interval of 14 days STORAGE into a neck musculature close to INDICATION Keep in a dry and dark place at a lymph-node before a blade- of 2 to 8 °C. Do not freeze! Immunoprophylaxis of infecous bone. bovine keratoconjuncvis in PACKAGE cale aged 1 months and above. Aer the angen contained in the 10 ml, 20 ml, 50 ml, 100 ml, From the immunological point of vaccine is applied into an animals 250 ml, 500 ml in glass view, the mass vaccinaon should body, the speciﬁc anbodies or plasc bole. be performed in all sensive against the infecous animals before the beginning keratoconjuncvis are formed of a grazing season. and protect the immunized animal against the disease menoned. Onset of immunity is 14 days aer the vaccinaon and lasts for 9 months.

46 2 Cale vaccines

Live vaccine for prevenon and treatment of Bovine trichophytosis (Ringworm) caused by Trichophyton verrucosum

TRICHOBEN lyophilisate and solvent for preparaon of injecon suspension for cale

COMPOSITION DOSAGE, ROUTE OF Immunity of the cellular type and Acve substance: ADMINISTRATION AND parally of the humoral type is A) Lyophilizate: Trichophyton VACCINATION SCHEME induced in the immunized verrucosum – min. 3,125 × 106 Dosage (prophylacc and animals. Onset of immunity is CFU, max. 18,75 × 106 CFU therapeuc): 1 month aer the revaccinaon B) Solvent: Diluent A Calves aged one day up to three and lasts at least 5 years. TARGET SPECIES months ………… 2 × 2 ml WITHDRAWAL PERIODS Cale from one day of age. Cale older than Meat: 14 days. three months …… 2 × 4 ml INDICATION The interval between the SHELF LIFE Both the prevenon and vaccinaon and the revaccinaon 3 years. The vaccine shall be treatment of bovine should be 5–14 days. consumed within 2 hours since trichophytosis. its dissoluon. All animals in the stables must be Applicaon: Intramuscular at the lumbar or gluteal region. STORAGE vaccinated. Vaccinaon is also Store and transport refrigerated necessary aer storing all newly For vaccinaon and revaccinaon (2 °C – 8 °C). Protect from frost. stopped 1–2 month calves and is recommended alternang right Protect from light. animals transferred, since and le sides of the body Trichophyton verrucosum is very Another (the third) revaccinaon PACKAGE resistant and survives in the can be performed 2–4 weeks 5 × 10 ml, 1 × 40 ml in glass environment for 6–8 years. aer the revaccinaon in the bole. animals aﬀected heavily with trichophyc changes and also in cachecc animals.

47 2 Cale vaccines

Avirulent live vaccine for prevenon and treatment of Bovine trichophytosis (Ringworm) caused by Trichophyton verrucosum

TRICHOBEN AV lyophilisate and solvent for preparaon of injecon suspension for cale

COMPOSITION DOSAGE, ROUTE OF WITHDRAWAL PERIODS Acve substance: ADMINISTRATION AND Meat: 14 days. A) Lyophilizate: Trichophyton VACCINATION SCHEME SHELF LIFE verrucosum avirulentum – Dosage (prophylacc and 3 years. The vaccine shall be min. 3,125 × 106 CFU therapeuc): 6 consumed within 2 hours since its max. 18,75 × 10 CFU Calves aged one day up to three dissoluon. B) Solvent: Diluent A months ... 2 × 2 ml Cale older than STORAGE TARGET SPECIES Store and transport refrigerated Cale from one day of age. three months ... 2 × 4 ml The interval between the (2 °C – 8 °C). Protect from frost. INDICATION vaccinaon and the revaccinaon Protect from light. For acve immunisaon of cale should be 5–14 days. PACKAGE to reduce clinical signs of Applicaon: Intramuscular 5 × 10 ml, 1 × 40 ml in glass dermatophytosis caused by bole. Trichophyton verrucosum at the lumbar or gluteal region. for prophylacc vaccinaon and For vaccinaon and revaccinaon for therapeuc use. is recommended alternang right All animals in the stables must be and le sides of the body vaccinated. Vaccinaon is also Another (the third) revaccinaon necessary aer storing all newly can be performed 2–4 weeks stopped 1–2 month calves and aer the revaccinaon in the animals transferred, since animals aﬀected heavily with Trichophyton verrucosum is very trichophyc changes and also resistant and survives in the in cachecc animals. environment for 6–8 years. Immunity is created within 1 month aer revaccinaon and it persists at least one year.

48 EQUINE

VACCINES

BioEquin F BioEquin FH BioEquin FT BioEquin H CLOTEID 4 FLUEQUIN FLUEQUIN T 3 TRICHOEQUEN 3 Equine vaccines

Novel vaccine containing inﬂuenza angens in according with the epidemiological situaon

BioEquin F, suspension for injecon for horses Vaccines against inﬂuenza

COMPOSITION DOSAGE SHELF LIFE Acve substances in one dose 1 ml deep intramuscularly. 33 months, aer the first opening Virus influenzae equorum Primary vaccinaon course in more doses: 10 hours. inacvatum, strains: First injecon at the age STORAGE A/Equi 2/Morava 95 1 6 months, second injecon Store in a refrigerator (European type) min. 5 log2 HIT is made 4 weeks later. (2 °C – 8 °C). A/Equi 2/Brno 08 (American type, Revaccinaon PACKAGE clade Florida 2) min. 5 log HIT1 The first revaccinaon (third 2 × 1 dose, 10 × 1 dose. 2 dose) is given 6 months aer 1 geometrical average of specific anbodies determinated by heamagglunaon the primary vaccinaon course inhibion test in serum of guinea pigs and further revaccinaon against Injecon suspension. influenza is carried out once in 12 months. TARGET SPECIES Revaccinate pregnant mares in Horse. the last trimester of pregnancy, INDICATION no later than one month before For acve immunizaon of horses the planned delivery. to reduce the occurrence of clinical signs caused by equine influenza virus and to reduce virus spreading aer infecon. Onset of immunity: 14 days aer primary vaccinaon Duraon of immunity: 6 months aer primary vaccinaon and 12 month aer first revaccinaon (third dose of vaccine).

50 3 Equine vaccines

Unique combinaon of current inﬂuenza angens and highly immunogenic strain of EHV-1

BioEquin FH emulsion for injecon for horses

COMPOSITION For acve immunizaon to Revaccinaon against equine Acve substances in one dose: reduce the occurrence of influenza and herpesvirus: Virus influenzae equorum aborons in pregnant mares The first revaccinaon (third inacvatum, strain: caused by equine herpesvirus dose) is administered 3 months A/Equi 2/Brno 08 (American (EHV-1) infecon. aer the primary vaccinaon and 1 type) H3N8 min. 6.0 log2 HIT Onset of acve immunity: next revaccinaon is carried out A/Equi 2/ Morava 95 (European 14 days aer primary vaccinaon every 6 months. type) H3N8 min. 6.0 log2 HIT1 Duraon of acve immunity: Vaccinaon of pregnant mares: Herpesvirus equorum To reduce the incidence of inacvatum (EHV-1) 6 months aer revaccinaon. 2 aborons caused by equine min. 2.1 log10 VNI DOSAGE herpesvirus infecon one dose Adjuvant(s): Vaccine dose – 1 ml. of the vaccine is administered to Oil adjuvant The vaccine is applied deep pregnant mares in the second (Montanide ISA 35 VG) 0.25 ml intramuscularly. Before use heat month aer mang and then Emulsion for injecon. the contents of the vial to in the fih or sixth month and The vaccine is a white, oily liquid a temperature of 15–25 °C in the ninth month of pregnancy. and shake well. with easily shakeable sediment. SHELF LIFE TARGET SPECIES Vaccinaon schedule: Shelf-life of the veterinary Horses. Primary vaccinaon against medicinal product as packaged equine influenza and for sale: 18 months. INDICATION herpesvirus: For acve immunizaon of horses Shelf-life aer first opening the The first vaccinaon at the age immediate packaging: 10 hours. to reduce the occurrence of of 6 months; the second respiratory infecon and clinical vaccinaon 4 weeks later. STORAGE signs caused by equine influenza Store in a refrigerator virus and equine herpesvirus (2 °C – 8 °C). Protect from light. (EHV-1). Store in a dry place. PACKAGE 2 × 1 dose, 10 × 1 dose.

51 3 Equine vaccines

Effecve combinaon of current influenza angens and purified tetanus toxoid

BioEquin FT emulsion for injecon for horses

COMPOSITION Onset of immunity has been Revaccinaon: Acve substances in one vaccine demonstrated by challenge test for The first revaccinaon is dose (1 ml) contains: equine influenza strain A/Equi administered 6 months aer the Inacvated virus equine influenza, 2/Brno 08, and by serology for strain primary vaccinaon and next strain: A/Equi 2/Morava 95. revaccinaon is carried out A/Equi 2/ Morava 95 (European Duraon of immunity has been every 12 months. 1 type), H3N8 min. 5 log2 HIT demonstrated by serology for both Revaccinaon of pregnant mares in A/Equi 2/Brno 08 (American type, vaccine influenza strains. the last trimester of pregnancy is 1 Florida 2), H3N8 min. 5 log2 HIT Influenza: Onset of acve immunity: carried out no later than one month Tetanus toxoid purified min. 30 IU2 14 days aer primary vaccinaon before the planned parturion. 1. geometrical average of specific anbodies Duraon of acve immunity: It is not recommended to use the determinated by heamagglunaon 6 months aer primary vaccinaon vaccine BioEquin FT for the inhibion test in serum of guinea pigs and at least 12 months aer the first revaccinaon of horses previously 2. Internaonal Units; tre of anbodies against toxin induced aer repeted revaccinaon (aer the third dose). vaccinated with the vaccine from vaccianon of guinea pigs determined by Tetanus: Onset of acve immunity: another manufacturer or ELISA method 14 days aer primary vaccinaon revaccinated the vaccine BioEquin Adjuvant(s): Duraon of acve immunity: FT by the vaccine of the another Aluminium hydroxide hydrated for 6 months aer primary vaccinaon manufacturer. Except the vaccines adsorpon 0.2 ml and at least 12 months aer the first containing the same strains Suspension for injecon. White revaccinaon (aer the third dose). of equine influenza. or yellowish to greyish brown DOSAGE AND ADMINISTRATION SHELF LIFE suspension, during storage sele ROUTE Shelf-life of the veterinary medicinal down sediment disperses aer Vaccine dose – 1 ml. product as packaged for sale: shaking. The vaccine is applied deep 33 months. Shelf-life aer first TARGET SPECIES intramuscularly. Before use heat opening the immediate packaging: Horses. the contents of the vial to a 10 hours. INDICATIONS FOR USE, temperature of 15–25 °C and STORAGE SPECIFYING THE TARGET SPECIES shake well. Store in a refrigerator (2 °C – 8 °C). For acve immunizaon of horses Vaccinaon schedule: Protect from frost. Protect from from 6 months of age against Primary vaccinaon: The first light. Store in a dry place. equine influenza to reduce clinical vaccinaon at the age of 6 months; PACKAGE signs and excrecon aer infecon, the second vaccinaon 4 weeks 2 × 1 dose, 10 × 1 dose and acve immunisaon against later. tetanus.

52 3 Equine vaccines

Vaccine against aborons cause EHV-1 provides paral cross immunity against EHV- 4

BioEquin H, emulsion for injecon for horses Inacvated vaccine against equine herpesvirus EHV-1

COMPOSITION Onset of acve immunity: Vaccinaon of pregnant mares: Acve substances in one dose: 14 days aer primary vaccinaon To reduce the incidence Herpesvirus equorum Duraon of acve immunity: of aborons caused by equine inacvatum (EHV-1) 6 months aer revaccinaon herpesvirus infecon one dose 1 min. 2.1 log10 VNI Use during pregnancy, lactaon of the vaccine is administered Adjuvant(s): or lay to pregnant mares in the second Oil adjuvant (Montanide Can be used during pregnancy. month aer mang and then ISA 35 VG) 0.25 ml The safety of the veterinary in the fih or sixth month and Emulsion for injecon. medicinal product has not been in the ninth month of pregnancy. The vaccine is a oily liquid, established during lactaon. SHELF LIFE creamy white, yellowish or pale DOSAGE Shelf-life of the veterinary pink colour, with easily shakeable Vaccine dose – 1 ml. medicinal product as packaged sediment. The vaccine is applied deep for sale: 18 months. TARGET SPECIES intramuscularly. Shelf-life aer first opening the Horses. Before use heat the contents immediate packaging: 10 hours. INDICATION of the vial to a temperature STORAGE For acve immunizaon of horses of 15–25 °C and shake well. Store in a refrigerator to reduce the occurrence Vaccinaon schedule (2 °C – 8 °C). Protect from light. Store in a dry place. of respiratory infecon and Primary vaccinaon: clinical signs caused by equine The first vaccinaon at the age of PACKAGE herpesvirus (EHV-1) and to 6 months; the second vaccinaon 2 × 1 dose, 10 × 1 dose. reduce the occurrence of 4 weeks later. aborons in pregnant mares caused by equine herpesvirus Revaccinaon: (EHV-1) infecon. The first revaccinaon (third dose) is administered 3 months aer the primary vaccinaon and next revaccinaon is carried out every 6 months.

53 3 Equine vaccines

Safe toxoid vaccine for long-term protecon against tetanus

CLOTEID 4 suspension for injecon Vaccine against tetanus

COMPOSITION INTERACTION WITH OTHER Basic vaccinaon: Acve substance in one dose: MEDICINAL PRODUCTS AND 2 doses at an interval of 3 weeks Anatoxinum tetanicum OTHER FORMS OF for animals older than 3 months puriﬁcatum RP ≥ 1 INTERACTION of age. Adjuvants: No informaon is available on the Revaccinaon: Algeldra suspensio 0,1 ml safety and eﬃcacy of this vaccine Revaccinaon is recommended Excipients: when administered concurrently aer two years, in horses aer Thiomersalum 0,15 mg with other veterinary medicinal 4 years. In indicated cases Suspension for injecon. products. Decision about using another booster dose can be this vaccine before or aer any administered earlier. TARGET SPECIES other veterinary medicinal Horses, cale, sheep, goats SHELF-LIFE product must be based on 36 months and dogs. consideraon of individual cases. INDICATION STORAGE DOSAGE Store in a refrigerator For the acve immunizaon The vial contents should be of horses, cale, sheep, goats (2 °C – 8 °C). Keep in a dry room. shaken before use. Protect from light. and dogs against tetanus from Dose - 1 ml, regardless of age, 3 months of age. weight and breed of an PACKAGE Onset of immunity: 14–21 days individual. 2 × 1 ml, 10 × 1 ml, 20 × 1 ml aer basic vaccinaon Method of administraon: Duraon of immunity: 2 years as intramuscular into the gluteal a minimum, 4 years in horses muscle. In horses, it is recommended to administer the product by the dry needle method, preferably into the gluteal muscle. In very restless horses, the product may be administered into the cervical or breast muscle.

54 3 Equine vaccines

Eﬀecve combinaon of three inﬂuenza angens

FLUEQUIN injecon suspension, for horses

COMPOSITION DOSAGE SHELF LIFE Acve substance in one dose: 1 ml deep intramuscularly. Shelf-life of the veterinary Virus influensis A/Equi 1/Praha Primary vaccinaon course medicinal product as packaged 56 inacvated, min. 160 HAU Primary vaccinaon course: First for sale 36 months. Virus influensis A/Equi 2/ injecon at the age of 3 to Shelf life aer the first opening Morava 95 (European type) 6 months, second injecon is in more doses: 10 hours. inacvated, min. 320 HAU made 4 to 6 weeks later. STORAGE Virus influensis A/Equi 2/ Revaccinaon Store in a refrigerator Brno 97 (American type) (2 °C – 8 °C). inacvated, min. 320 HAU The first revaccinaon (third dose) is given 6 months aer the PACKAGE Injecon suspension. primary vaccinaon course. 2 × 1 dose, 10 × 1 dose. TARGET SPECIES Further revaccinaons take place Horse. at 6 to 12-month intervals INDICATION depending on the infecon Prevenve vaccinaon of horses situaon. against influenza. Revaccinate pregnant mares in Onset of immunity: Solid the last trimester of pregnancy, immunity starts 21 days following no later than one month before revaccinaon. the planned delivery. Duraon of immunity: 6 months Note: In the case of foals born aer primary vaccinaon course. from mares demonstrably vaccinated before the delivery we recommend to vaccinate the foals at the age of 6 months due to the colostral immunity.

55 3 Equine vaccines

Combinaon of inﬂuenza angens and tetanus toxins for yearly revaccinaon

FLUEQUIN T injecon suspension, for horses

COMPOSITION DOSAGE SHELF LIFE Acve substance in one dose: 1 ml deep intramuscularly. 36 months, aer the first opening Virus influensis A/Equi 1/Praha Primary vaccinaon course in more doses: 10 hours. 56 inacvated, min. 160 HAU Primary vaccinaon course: STORAGE Virus influensis A/Equi 2/ First injecon at the age of 3 to Store in a refrigerator Morava 95 (European type) 6 months, second injecon is (2 °C – 8 °C). inacvated, min. 320 HAU made 4 to 6 weeks later. Virus influensis A/Equi 2/ PACKAGE Brno 97 (American type) Revaccinaon 2 × 1 dose, 10 × 1 dose. inacvated, min. 320 HAU The first revaccinaon (third Tetanus anatoxin, dose) is given against influenza purified min. 150 IU 6 months aer the primary vaccinaon course and against Injecon suspension. tetanus once in 12 months. TARGET SPECIES Further revaccinaon against Horse. influenza and tetanus is carried INDICATION out once in 12 months. Prevenve vaccinaon of horses Revaccinate pregnant mares in against influenza and tetanus. the last trimester of pregnancy, Onset of immunity: Solid no later than one month before immunity comes within 14 to the planned delivery. 21 days aer revaccinaon Note: In the case of foals born Duraon of immunity: Against from mares demonstrably influenza for at least 6 months vaccinated before the delivery we aer primary vaccinaon course recommend to vaccinate the and 12 months aer first foals at the age of 6 months due revacccinaon. Against tetanus to the colostral immunity. 12 months aer primary vaccinaon course.

56 3 Equine vaccines

Vaccine for successful management of trichophytosis in horses

TRICHOEQUEN inj. sicc. ad us. vet. Vaccine against equine trichophytosis

COMPOSITION DOSAGE SHELF LIFE Lyophilisate Prophylacc: 18 months, the vaccine must be Acve ingredient in one dose:  foals from the age of four used within 2 hours aer Trichophyton equinum reconstuon. 6 6 months ll the age of twelve min. 4×10 CFU, max. 16×10 CFU months: 2 × 2.5 ml STORAGE Solvent  Store in a dark and dry place Diluent A 1 ml horses above twelve months of age: 2 × 5 ml under a temperature TARGET SPECIES Interval between vaccinaon and of 2 °C – 8 °C. Horse from the age of 4 months. revaccinaon is 10–16 days. PACKAGE INDICATION Therapeuc: 1 × 5 ml, 5 × 5 ml, 1 × 25 ml, For prophylaxis and therapy In foals and horses over 4 months 1 × 50 ml. of equine trichophytosis. twice 5 ml with an interval USAGE DURING PREGNANCY of 10–16 days. The third The vaccine may be administered applicaon of the vaccine to pregnant animals in the whole in a therapeuc dose is period of pregnancy without any recommended in case risk of adverse eﬀects for youth of an extensive aﬀecon. and pregnant animals. 10–16 days aer revaccinaon. INTERACTION WITH OTHER Method of administraon MEDICINAL PRODUCTS Intramuscular, to the neck muscle Oral or parenteral treatment or in to gluteal muscle. with anmycoc agents is not Vaccinaon is recommended to recommended together the le half of the body and with vaccinaon. revaccinaon to the right half of the body.

57 58 FELINE VACCINES

Biofel B Biofel M Plus Biofel PCH 4 Biofel PCHR 4 Feline vaccines

Unique inacvated feline vaccine against Lyme borreliosis with Borrelia garinii and Borrelia afzelii bacterial subtypes

Biofel B inj. ad us. vet. Inacvated vaccine against feline Lyme borreliosis

COMPOSITION INDICATION SHELF LIFE 1 dose – 1 ml: For acve immunizaon of cats 2 years. th Acve compounds: over 12 week of age against STORAGE Borrelia burgdorferi sensu lato Lyme borreliosis. In a dark and dry place at the inacvata: DOSAGE temperature 2 – 8 °C. Borrelia garinii RP  1 Dose – 1 ml irrespecve of age, Do not freeze! Borrelia afzelii RP  1 weight and race of the individual, (RP = relave potency related to standard PACKAGE which complies with challege test on target but not earlier than at the age of 2 × 1 ml, 10 × 1 ml, 20 × 1 ml. animals) 12 weeks of kiens. Excipients: In case of primary vaccinaons, Algeldra suspensio 2 % 0.1 mg the revaccinaon shall be made Natrii chloridi soluo ad 1 ml at the interval of 14 – 21 days. TARGET SPECIES In order to maintain permanent Cats. immunity, the revaccinaon should be repeated every year.

Method of administraon: - subcutaneously, preferably at the region behind the blade- bone, - intramuscularly, preferably to the musculature of the pelvis extremity.

60 4 Feline vaccines

Unique vaccine for prophylaxis and treatment of dermatophytosis

Biofel M Plus injecon suspension for cats Vaccine against Microsporum canis in cats inacvated

COMPOSITION DOSAGE SHELF LIFE Acve substance: 1 ml of the vaccine can be Shelf-life of the veterinary Microsporum canis inact. – applied to animals aged two medicinal product as packaged min. 1 million of vegetave months and above, regardless for sale: 18 months. forms of the age, weight and race STORAGE TARGET SPECIES of the individual. Store in a refrigerator Cats. Applicaon: deep (2 °C – 8 °C). Do not freeze. INDICATION intramuscularly into the Protect from light. Store in a dry. For the prevenon and therapy musculature of the pelvis PACKAGE of dermal mycoses in cats extremity or subcutaneously 2 × 1 ml, 10 × 1 ml, 20 × 1 ml, induced by the dermatophyte behind the blade-bone. 50 × 1 ml, 100 × 1 ml. Microsporum canis. Animals The vaccinaon should be carried should be vaccinated at the age out into the le body side and of 2 months and above. the revaccinaon into the right The immunity develops within body side. 1 month aer revaccinaon Prevenve and therapeuc use: and persists for at least 1 year. animals shall be vaccinated twice at the interval of 10–21 days between the ﬁrst and the second vaccinaon. The third vaccinaon dose can be applied, if necessary for therapeuc purposes, 10–21 days aer the revaccinaon.

61 4 Feline vaccines

Inacvated vaccine safe even for the chronically ill and immunodeﬁcient cats

Biofel PCH emulsion for injecon for cats Vaccine against panleucopenia, calicivirus and herpesvirus infecon of cats

COMPOSITION INDICATION Revaccinaon Acve substance: For acve immunizaon against Further regular revaccinaons by Virus panleucopeniae panleucopenia, calicivirus and the vaccine Biofel PCHR are contagiosae felis herpesvirus infecon of cats. carried out in 12-month intervals. inacvatum RP ≥ 1 The protecve immunity is SHELF LIFE Calicivirus felis created within 2–4 weeks aer 24 months. inacvatum RP ≥ 1 revaccinaon. The duraon Herpesvirus felis of immunity is 12 months. STORAGE inacvatum RP ≥ 1 Store in a refrigerator AMOUNTS TO BE (2 °C – 8 °C). Protect from light. RP = Relave potency (ELISA test) by ADMINISTERED AND comparison with reference serum obtained Protect from frost. ADMINISTRATION ROUTE from guinea pigs aer vaccinaon with PACKAGE vaccine batch conforming to challenge test Dose - 1 ml irrespecve of age, on target animal. weight and breed, but not sooner 2 × 1 dose, 10 × 1 dose, Oil adjuvant than in the eighth week of age. 5 × 5 doses, 10 × 5 doses, (Emulsigen) ad 1 ml Method of administraon: 20 × 1 dose, 100 × 1 dose, TARGET SPECIES subcutaneously, preferably in the 1 × 5 doses Cats. area behind the shoulder blade. VACCINATION SCHEDULE Basic vaccinaon Two vaccinaons at intervals of 3–4 weeks.The ﬁrst vaccinaon with one dose of vaccine Biofel PCH from age 8 to 10 weeks and the second vaccinaon with one dose of vaccine Biofel PCHR from the age of 3 months.

62 4 Feline vaccines

A smart combinaon with rabies in one vial, in one shot

Biofel PCHR emulsion for injecon for cats Vaccine against feline panleucopenia, herpesvirus, calicivirus infecon and rabies

COMPOSITION DOSAGE SHELF LIFE Acve substance: Dose – 1 ml regardless of age, 24 months. Virus panleucopeniae weight and breed of the STORAGE contagiosae felis inacvatum individual; but not sooner than 3,0 Store in a refrigerator min. 10 TCID50 in the third month of age. (2 °C – 8 °C). Protect from light. Calicivirus felis inacvatum 5,5 Route of administraon: Protect from frost. min. 10 TCID50 Subcutaneously, preferably in the PACKAGE Herpesvirus felis inacvatum area behind the shoulder blade. 5,0 2 × 1 dose, 10 × 1 dose, min. 10 TCID50 Cats are vaccinated from the age 5 × 5 doses, 10 × 5 doses, Virus rabiei of 8 to 10 weeks using Biofel PCH inacvatum min 1 IU 20 × 1 dose, 100 × 1 dose, vaccine. 1 × 5 doses. TARGET SPECIES Revaccinaon is carried out Cats. within 3–4 weeks aer the INDICATION primary vaccinaon with the For acve immunizaon of cats vaccine Biofel PCHR. Biofel PCHR against panleucopenia, vaccine may be administered calicivirus, herpesvirus infecon from the age of 3 months. and rabies. The onset of protecve immunity is 2 to 4 weeks aer the revaccinaon. Further regular revaccinaons by the vaccine Biofel PCHR are carried out in 12 month intervals.

63 64 POULTRY VACCINES

LIVE VACCINES ORNIBRON H120 ORNIBRON H120 + D274 ORNIBUR Intermediate ORNIBUR Intermediate Plus ORNIMIX CLONE B1-Hitchner + H 120 ORNIPEST CLONE ORNIPRIM CLONE B1 SALGEN

INACTIVATED VACCINES ORNIDUCK ORNIVAC EDS ORNIVAC ND ORNIVAC ND+GO ORNIVAC ND+GO+IB+EDS ORNIVAC ND+IB2+EDS 5 PMV-Salmovac 5 Poultry vaccines

Live aenuated freeze-dried vaccine against Infecous Bronchis

ORNIBRON H120 lyophilizate for suspension for domesc fowl

COMPOSITION DOSAGE AND SHELF LIFE Each dose of the vaccine contains ADMINISTRATION 30 months infecous Bronchis virus Chickens could be vaccinated 3 5.3 STORAGE strain H 120 10 – 10 EID50. since the age of day-one by spray Store in a refrigerator TARGET SPECIES on chickens, by eye drop or into (2 °C – 8 °C). Do not freeze. Broilers, breeders and the nostril (dilute the vaccine in Store in a dry place protected commercial layers. puriﬁed dislled water or water from light. for injecon). INDICATIONS For oral vaccinaon chickens PACKAGING Acve immunizaon against should develop the habit of water 10 vials each containing 500, infecous bronchis. consumpon from drinkers; 1000, 2500 and 5000 doses. dilute the vaccine in fresh drinking water and provide to birds in an appropriate drinking system.

66 5 Poultry vaccines

Live aenuated freeze-dried vaccine against Infecous Bronchis containing two strains

ORNIBRON H120 + D274 lyophilizate for the preparaon of suspension for domesc fowl

COMPOSITION INDICATIONS SHELF LIFE Each dose of the vaccine contains Acve immunizaon of chickens 30 months. infecous bronchis virus (IB) since the age of day-one against 3.0 4.8 STORAGE strain H120 10 – 10 EID50 and Infecous Bronchis caused by 3.0 4.8 Store in a refrigerator strain D247 10 – 10 EID50, Massachuses serotype strains (2 °C – 8 °C). Do not freeze. respecvely. of infecous bronchis virus Store in a dry place protected TARGET SPECIES and/or variant strain belonging from light. to D274 protectotype. Broilers, breeders and PACKAGING commercial layers. DOSAGE AND 10 vials each containing 1000, ADMINISTRATION 2500 and 5000 doses of the Since the age of day-one by spray vaccine. on chickens, by eye drop or into the nostril (dilute the vaccine in puriﬁed dislled water or water for injecon). For oral vaccinaon dilute the vaccine in fresh drinking water and provide in an appropriate drinking system.

67 5 Poultry vaccines

Live aenuated freeze-dried intermediate vaccine against Infecous Bursal Disease (Gumboro Disease)

ORNIBUR Intermediate lyophilisate for suspension for domesc fowl

COMPOSITION DOSAGE AND STORAGE Each dose of the vaccine contains ADMINISTRATION Store in a refrigerator Infecous Bursal Disease Virus, Dilute the vaccine in fresh (2 °C – 8 °C). Do not freeze. 4.0 5.2 Bio OP-23 10 – 10 TCID50. drinking water and provide to Store in a dry place protected TARGET SPECIES chickens using an appropriate from light. Broilers, breeders and drinker. PACKAGING commercial layers. When low or no maternal 10 vials each containing 500, anbody is detected or in farms 2000 and 5000 doses. INDICATIONS endangered with potenal Acve immunizaon of chickens infecon, vaccinaon can be against Infecous Bursal Disease performed as early as the age (IBD). of 7 to 15 days. Revaccinate 1–2 weeks aer primary vaccinaon. SHELF LIFE 24 months.

68 5 Poultry vaccines

Live aenuated freeze-dried Intermediate Plus vaccine against Infecous Bursal Disease (Gumboro Disease)

ORNIBUR Intermediate Plus lyophilizate for the preparaon of suspension for domesc fowl

COMPOSITION DOSAGE AND STORAGE Each dose of the vaccine contains ADMINISTRATION Store in a refrigerator infecous Bursal Disease Virus, Dilute the vaccine in fresh (2 °C – 8 °C). Do not freeze. strain IBDV OP-1, drinking water and provide to Store in a dry place protected 4.0 5.2 min. 10 – 10 TCID50. chickens using an appropriate from light. TARGET SPECIES drinker. PACKAGING Broilers, breeders and Primary vaccinaon 7–21 days 10 vials each containing 500, commercial layers. of age, in infecon endangered 1000, 2500 or 5000 doses. ﬂocks since the age of 7 days. INDICATIONS Revaccinate 1–2 weeks aer Acve immunizaon of chickens primary vaccinaon. from the age of day-7 against IBD. The vaccine has the capacity SHELF LIFE of breaking through maternal 30 months. anbodies, hence it can be recommended for a relavely early age vaccinaon when the farm's epidemiological situaon requires. Ornibur Intermediate Plus vaccine is parcularly recommended for ﬂocks endangered with very virulent strain of IBD virus.

69 5 Poultry vaccines

Live aenuated freeze-dried bivalent vaccine against Newcastle Disease and Infecous Bronchis

ORNIMIX CLONE B1-Hitchner + H 120 lyophilizate for the preparaon of suspension for chickens

COMPOSITION DOSAGE AND SHELF LIFE Each dose contains aenuated ADMINISTRATION 24 months strains of Newcastle Disease virus The vaccine is administered to 6.0 7.5 STORAGE Bio 52, NDV B1 10 – 10 EID50 day-old chickens by spraying or Store in a refrigerator and Infecous Bronchis virus by drinking water. (2 °C – 8 °C). Do not freeze. Bio 53, IBV H 120 For water vaccinaon, dilute the 3.0 4.8 Store in a dry place protected 10 – 10 EID50. vaccine in fresh drinking water from light. TARGET SPECIES and provide to chickens using an appropriate drinker. PACKAGING Broilers, breeders and 10 vials each containing 200, commercial layers. Revaccinaon can be performed aer 4 weeks and 6 weeks 1000, 2500 and 5000 doses. INDICATIONS following spray or via drinking Intended for administraon to water vaccinaon, respecvely. healthy chickens as an aid to prevent Infecous Bronchis and Newcastle Disease. Advantage of incorporang both vaccines into a single vaccine is to:  reduce double vaccinaon stress on chickens,  reduce cost and work load of double vaccinaon,  provide reasonable gap for other vaccines,  protect chickens from an early age infecon by both disease agents.

70 5 Poultry vaccines

Live aenuated freeze-dried vaccine of LaSota strain against Newcastle Disease

ORNIPEST CLONE lyophilisate for suspension for domesc fowl

COMPOSITION DOSAGE AND STORAGE Each dose of the vaccine contains ADMINISTRATION Store in a refrigerator Newcastle Disease Vaccine strain Spray on day-old chickens or (2 °C – 8 °C). Do not freeze. 6.0 8.0 La Sota SL 93 10 – 10 EID50. install droplet into the eye or Store in a dry place protected TARGET SPECIES nostril (dilute the vaccine in from light. Broilers, breeders and puriﬁed dislled water or water PACKAGING commercial layers. for injecon). 10 vials each containing For oral vaccinaon dilute the 200 doses, 500 doses, 1000 doses INDICATIONS vaccine in fresh drinking water. Intended for administraon to and 2500 doses. healthy chickens as an aid to SHELF LIFE prevent Newcastle Disease. 30 months.

71 5 Poultry vaccines

Live aenuated freeze-dried vaccine of lentogenic strain against Newcastle Disease

ORNIPRIM CLONE B1 lyophilizate for the preparaon of suspension for chickens

COMPOSITION TARGET SPECIES SHELF LIFE Each dose of the vaccine contains Broilers, breeders and 30 months. Newcastle Disease virus strain commercial layers. STORAGE Hitchner (B1) Bio 52 NDV B1 6.0 7.5 DOSAGE AND Store in a refrigerator 10 – 10 EID50. ADMINISTRATION (2 °C – 8 °C). Do not freeze. INDICATIONS Day-old chickens can be Store in a dry place protected Intended for primary vaccinaon vaccinated by spraying using from light. of healthy chickens as an aid to spray cabinet. The vaccine can PACKAGING prevent Newcastle Disease. also be applied into the nostril or 10 vials each containing Depending on the by eye drop. For the eye and nose 200 doses, 500 doses, 1000 doses epidemiological condion of the droplets, the vaccine should be and 2500 doses.. farm chickens can be diluted in puriﬁed dislled water revaccinated with Orniprim Clone or water for injecon. or Ornipest Clone. Another way of mass vaccinaon is applicaon via fresh drinking water.

72 5 Poultry vaccines

Live aenuated freeze-dried vaccine against Avian Salmonelosis

SALGEN Vaccine against Avian Salmonelosis, aenuated

COMPOSITION INDICATIONS STORAGE Aenuated Salmonella Acve immunizaon against Store in a refrigerator typhimurium 2×106 – 3.8×107 CFU salmonella serotypes group B and (2 °C – 8 °C). Do not freeze. in a stabilizer. Oral lyophilisate to D to reduce faecal shedding of Store in a dry place protected be reconstuted with fresh S. typhimurium and colonizaon from light. drinking water for oral of internal organs with the PACKAGING vaccinaon. bacterium. 20 ml and 50 ml vials either per TARGET SPECIES DOSAGE AND 1 vial or 5 vials packed in a box. Gallinaceous species (domesc ADMINISTRATION For dosage informaon see fowl, water fowl, pheasants and The lyophilised vaccine is diluted product leaﬂet. pigeons). in an appropriate volume of fresh drinking water and administered orally via drinking water. SHELF LIFE 24 months.

73 5 Poultry vaccines

Inacvated oil emulsion vaccine against Duck Infecous Hepas

ORNIDUCK emulsion for injecon for ducks

COMPOSITION INDICATIONS SHELF LIFE Each dose of the vaccine contains For acve immunizaon 24 months. Virus hepas infecosae of mature ducks in a breeding STORAGE anatum inacvatum and producon ﬂocks. Ducklings 5.0 Store in a refrigerator min. 10 KELD50. from vaccinated ducks receive (2 °C – 8 °C). Do not freeze. TARGET SPECIES passive immunity that protects Store in a dry place protected Ducks. them from early age infecon. from light. DOSAGE AND PACKAGING ADMINISTRATION 100 ml bole each containing 0.5 ml of the vaccine is 200 doses packed either singly inoculated intramuscularly into or in a pack of 12 or 20 boles. the breast muscle. 250 ml bole containing 500 doses. 500 ml bole containing 1000 doses.

74 5 Poultry vaccines

Inacvated oil emulsion vaccine against Egg Drop syndrome

ORNIVAC EDS emulsion for injecon for domesc fowl

COMPOSITION DOSAGE AND PACKAGING Each dose of the vaccine contains ADMINISTRATION Boles of 50 ml – 150 doses, inacvated adenovirus EDS strain 0.5 ml of the vaccine is 100 ml – 300 doses, min. 1,000 HAU. inoculated intramuscularly into 250 ml – 750 doses, TARGET SPECIES the breast muscle. Usually 500 ml – 1500 doses. Broiler breeders and layers. pullets are vaccinated 2–4 weeks before point of lay INDICATIONS (16–20 weeks of age). Acve immunizaon of parent ﬂocks against EDS. Vaccinated SHELF LIFE parents subsequently pass to 12 months. their progenies immunity STORAGE against EDS. Store in a refrigerator (2 °C – 8 °C). Do not freeze. Store in a dry place protected from light.

75 5 Poultry vaccines

Inacvated oil emulsion monovalent vaccine against Newcastle Disease

ORNIVAC ND emulsion for injecon for domesc fowl

COMPOSITION DOSAGE AND SHELF LIFE One dose of 0.3 ml of the vaccine ADMINISTRATION 18 months from the date of contains an inacvated Individual applicaon to each manufacture and 10 hours, pseudopess avium, strain NDV pullet by injecon of the vaccine if the vaccine is opened for use, SL-93 at a concentraon into the breast muscle provided the vaccine is kept of > 4 log2 HIT. For each bird the volume under the recommended TARGET SPECIES of 0.3 ml is applied using temperature (2 °C – 8 °C). Broiler breeders and layers. a sterile needle. STORAGE Usually vaccinaon is performed INDICATIONS Store in a refrigerator since the age of 16 weeks, (2 °C – 8 °C). Do not freeze. Acve immunisaon of poultry abobut 4 weeks before pullets against Newcastle disease. To be Store in a dry place protected are transferred to the egg laying from light. used as a booster aer previous house. Ornivac ND is the best administraon of a live vaccine. booster of immunity against ND PACKAGING Immunity starts not later than when the vaccine is applied to 240 ml vial containg 800 doses 14 days aer vaccinaon and chickns that are primed with 480 ml bole containing lasts unl the end of lay. The the corresponding live vaccine. 1600 doses onset and duraon of immunity Immunity persists unl the end Individual packcaging: were proved serologically. of the egg laying period. 1 × 800 doses, 1 × 1600 doses Mulple packaging in cartons: 10 × 800 doses, 10 × 1600 doses

76 5 Poultry vaccines

Inacvated oil emulsion bivalent vaccine against Newcastle Disease and Infecous Bursal Disease

ORNIVAC ND+GO emulsion for injecon for domesc fowl

COMPOSITION DOSAGE AND SHELF LIFE Each dose of the vaccine ADMINISTRATION 18 months. contains: A dose of 0.3 ml is inoculated STORAGE 1) Paramyxovirus pseudopess intramuscularly into the breast Store in a refrigerator avium ante inacvatum muscle or subcutaneously at the 8.0 (2 °C – 8 °C). Do not freeze. min. 10 EID50 back of the neck. Usually pullets Store in a dry place protected 2) Virus bursidis infecosae are vaccinated 2–4 weeks before from light. avium ante inacvatum onset of the egg laying period. 6.3 PACKAGING min. 10 TCID50. Primary vaccinaon with the Boles of 50 ml – 100 doses, TARGET SPECIES corresponding live vaccine is recommended (ND, IBDV). 100 ml –200 doses, Broiler breeders and layers. 250 ml – 500 doses, INDICATIONS 500 ml – 1000 doses. Immunizaon of broiler breeder pullets and layers. Vaccinated parents subsequently pass to their progenies immunity against ND and IBDV

77 5 Poultry vaccines

Inacvated oil emulsion quadrivalent vaccine against Newcastle Disease, Infecous Bursal Disease, Infecous Bronchis and Egg drop syndrome

ORNIVAC ND+GO+IB+EDS emulsion for injecon for domesc fowl

COMPOSITION TARGET SPECIES SHELF LIFE Each dose of the vaccine Broiler breeders and layers. 18 months. contains: INDICATIONS STORAGE a) Paramyxovirus pseudopess Immunizaon of broiler breeder Store in a refrigerator avium, NDV strain SL-93 8.6 pullets and commercial layers in (2 °C – 8 °C). Do not freeze. min. 10 EID50 order to protect them from ND, Store in a dry place protected b) Virus bursidis infecosae IBD, IB and EDS. Vaccinated from light. avium ante inacvatum, IBDV layers then pass protecve PACKAGING strain OP-23 strain immunity against ND, IBDV, IB 6.6 In boles of min. 10 TCID50 and EDS to their oﬀspring via 50 ml – 100 doses, c) Virus bronchidis infecosae the egg. avium ante inacvatum, IBV 100 ml –200 doses, strain M-41 strain DOSAGE AND 250 ml – 500 doses, 6.8 ADMINISTRATION 500 ml – 1000 doses. min. 10 EID50 d) Adenovirus EDS 76 ante A dose of 0.5 ml is inoculated inacvatum min. 1000 HAU. intramuscularly into the breast muscle or subcutaneously at the back of the neck. Usually pullets are vaccinated 2–4 weeks before onset of the egg laying period. Primary vaccinaon with the corresponding live vaccine is recommended.

78 5 Poultry vaccines

Inacvated oil emulsion trivalent vaccine against infecous bronchis, Newcastle Disease and Egg Drop syndrome

ORNIVAC ND+IB2+EDS emulsion for injecon for domesc fowl

COMPOSITION DOSAGE AND SHELF LIFE Each dose of the vaccine contains ADMINISTRATION 18 months. a) Newcastle Disease Virus 0.5 ml of the vaccine is STORAGE strain SL-93, min. 24 HIU, inoculated intramuscularly into Store in a refrigerator b) 2 strains of Infecous the breast muscle. Usually (2 °C – 8 °C). Do not freeze. Bronchis Virus pullets are vaccinated 6.2 Store in a dry place protected (IBV M-41 – min. 2 HIU 2–4 weeks before point of lay from light. and IBV D 274, min. 26.3). (16–20 weeks of age). c) Adenovirus EDS strain PACKAGING Bio 56, min. 26,5 HIU. Boles of 50 ml – 100 doses, 100 ml –200 doses, TARGET SPECIES 250 ml – 500 doses, Broiler breeders and layers. 500 ml – 1000 doses. INDICATIONS Acve immunizaon of parent ﬂocks and layers to induce immunity against ND, IB serotype Massachuses and strain D274 and EDS. Vaccinated parents subsequently pass to their progenies immunity against ND, IBDV and EDS.

79 5 Poultry vaccines

Inacvated oil emulsion bivalent vaccine against Pigeon Paramyxovirus and salmonellosis

PMV-Salmo-Vac emulsion for injecon for pigeons

COMPOSITION DOSAGE AND STORAGE Salmonella typhimurium subsp. ADMINISTRATION Store in a refrigerator copenhagen, strain 1, 4, 12 : i : 1, 0.3 ml of the vaccine is applied (2 °C – 8 °C). Do not freeze. 2, inacvatum RP ≥ 1* subcutaneously in the back Store in a dry place protected Paramyxovirus pseudopess of the neck. Primary vaccinaon from light. avium, strain NDV SL-93, of young pigeons takes place PACKAGING inacvatum RP ≥ 1* at 3–4 weeks of age and Vials of 10 ml, 20 ml, and 50 ml *RP = Relave potency (ELISA test) revaccinaon at an interval each containing 25, 60 and compared with the reference serum of 4 weeks. The second 150 doses, respecvely. obtained aer vaccinaon of mice with a vaccinaon should not be applied vaccine batch that has successfully passed the challenge test on the target species. later than 3 weeks before ﬂight or exhibion. TARGET ANIMAL SPECIES Not all packaging sizes are Adult pigeons which have already Pigeons. available in certain market been vaccinated with territories INDICATIONS PMV-Salmo-Vac should be For acve immunizaon of revaccinated annually and pigeons against paraxymovirus 2–3 weeks before mang. (ND) and salmonellosis since the SHELF-LIFE age of 3 weeks. The salmonellosis 18 months. part of the vaccine helps to reduce colonizaon of the gastrointesnal tract and excreon of the strains S. typhimurium var. Copenhagen, S. enterica subsp. Enterica serowar typhi, S. paratyphi A, S. hirschfeldii (S. paratyphi C), S. anatum, S. senenberg via faeces.

80 RABBIT

VACCINES

MYXOREN PASORIN-OL PESTORIN PESTORIN RHDV2 PESTORIN MORMYX 6 TRICHOPELEN 6 Rabbit vaccines

Vaccine containing immunogenic strain of myxomavirus for three diﬀerent methods of administraon

MYXOREN lyophilisate and solvent for parenteral use Vaccine against myxomatosis vivid MXT

COMPOSITION into an auricle, 1.5 ml and 0.8 ml the immunity then lasts for Poxvirus myxomatosae of the diluent is contained at least 6 months. The next 3.3 aenuatum min. 10 TCID50 in the package that is suﬃcient revaccinaon should be 5.8 max. 10 TCID50 for 100 doses and 50 doses, performed not later than Diluent A - Natrii chloridum – respecvely. 6 months aer the last 8.34 mg, Kalii chloridum – In subcutaneous applicaon, vaccinaon. 0.21 mg, Natrii the amount of diluent is 20 ml or Two vaccinaons a year, namely, hydrogenophosphas – 2.47 mg, 10 ml and it represents 20 doses the vaccinaon in springme and Kalii dihydrogenophosphas – or 10 doses s.c. the revaccinaon during summer, 0.21 mg, Aqua pro injecone In applicaon using the needless should be preferably performed ad 1.0 ml. applicator with the dose of in breeding rabbits in regions Lyophilisate and solvent 0.2 ml, the amount of diluent is with unfavourable infecon for parenteral use. 20 ml or 10 ml and it represents condions. For rabbits. 80 or 40 needles doses. When SHELF LIFE INDICATIONS using needles applicator with 2 years, the vaccine shall be Prevenve vaccinaon of 0.1 ml dose, the amount of consumed within 4 hours since clinically healthy rabbits against diluent is 10 ml or 5 ml and such its diluon! myxomatosis. diluted vaccine represents 100 or 50 doses. STORAGE ADMINISTRATION ROUTE AND Anbodies obtained from Store in a dry and dark place DOSAGE mothers inhibit the vaccinaon at a temperature of 2 to 8 °C. The vaccine can be either eﬀect; the animals should not be PACKAGE injected into an auricle using a therefore vaccinated earlier than 1 × 10, 5 × 10, 5 × 20 special double needle or applied at the age of 4 weeks. In case of subcutaneous doses, 1 × 40, subcutaneously in a backbone the single vaccinaon performed 1 × 80, 1 × 50, 1 × 100, 5 × 40, region or a needless applicator at the age of 10 weeks and above 5 × 80, 5 × 50, 5 × 100 needless (does 0.1 or 0.2 ml). the immunity lasts for at least dose, 1 × 50, 1 × 100, 5 × 50, The single-dose package intended 6 months. If an animal is 5 × 100 doses applied with for a subcutaneous applicaon immunized earlier than at the age double needle. contains 1 ml of the diluent. of 10 weeks, it should be Single-dose packages: 1 × 1, 5 × 1, If the vaccine is to be injected revaccinated 6 weeks later and 10 × 1 subcutaneous dose.

82 6 Rabbit vaccines

Simple protecon against diﬃcultly treatable infecon of respiratory tract

PASORIN-OL inj. ad us. vet. Vaccine against rabbit pasteurellosis

COMPOSITION DOSAGE MODE OF ADMINISTRATION Suspension: Rabbits between 4th and 6th week Subcutaneous. Suspension Pasteurella multocida of age 0.5 ml 10 th SHELF LIFE A, D min. 1. 10 Rabbits over 7 week of age 1 year, aer the first opening Adjuvant: Emulsio olei 1 ml within 10 hours ad 1.0 ml Recommended vaccinaon schedule: STORAGE INDICATION Store in a dry and dark place The vaccine serves for rabbit  the 1st vaccinaon dose th at temperatures between pasteurellosis in the 4 week of age, 2 and 8 °C. immunoprophylaxis.  the 2nd vaccinaon dose Do not freeze. th USE DURING PREGNANCY, in the 7 week of age, PACKAGE LACTATION  the 3rd vaccinaon dose 1 × 20 ml, 1 × 100 ml 14 days aer vaccinaon and in the 10th week of age within 14 days aer (breeding rabbits). revaccinaon, doe rabbits may Further regular immunizaon show a lower rate of pregnancy always with one vaccine dose (up to 15 %). Other negave every 6 months. influences on pregnancy and When vaccinang older rabbits lactaon were not observed. for the first me, immunize twice Interacon with other medicinal at an interval of 3 weeks, further products and other forms regular immunizaons with one of interacon vaccine dose every 6 months. The vaccine may be administered simultaneously with Pestorin- Mormyx inj.sicc.a.u.v. vaccine.

83 6 Rabbit vaccines

Safe inacvated vaccine for easy subcutaneous administraon against RHD

PESTORIN suspension for injecon for rabbit Vaccine against Rabbit Haemorrhagic Disease

COMPOSITION INTERACTION WITH OTHER AMOUNTS TO BE Acve substance in one dose: MEDICINAL PRODUCTS ADMINISTERED AND Calicivirus sepcemiae AND OTHER FORMS ADMINISTRATION ROUTE haemorrhagiae cuniculi (soluo OF INTERACTION 1 ml subcutaneously, regardless organorum) – min. 128 HA Combinaon of vaccines – of animal weight. Adjuvant: Aluminium hydroxide concurrently with subcutaneous SHELF LIFE hydrated for adsorpon. aplicaon of the vaccine against 2 years, aer ﬁrst opening INJECTION RHD the any applicaon of the container – 10 hours. For rabbits. a vaccine against myxomathosis (live MXT – according to enclosed STORAGE INDICATION Store in a dark and cold place at Package Insert for the Vaccine o For prevenve vaccinaon against myxomathosis is possible. temperatures between 2 and 8 C of healthy rabbits against viral The vaccine shall not be mixed The vaccine shall not be allowed haemorrhagic disease of rabbits. due to their diﬀerent to freeze! USE DURING PREGNANCY, characteriscs. PACKAGE LACTATION OR LAY 2 × 1 dose, 5 × 1 dose, Can be used during pregnancy. 10 × 1 dose, 1 × 10 doses, It is not recommended to 1 × 20 doses, 5 × 20 doses, vaccinate doe rabbits in the last 1 × 50 doses week of pregnancy due to hazard of aboron by a strong grip.

84 6 Rabbit vaccines

Inacvated vaccine for rabbits against RHDV-2 in 0.5 ml dose

PESTORIN RHDV2 suspension for injecon for rabbits

COMPOSITION INDICATIONS SHELF LIFE Acve substance: For acve immunisaon of Shelf life: 9 months. Calicivirus sepcemiae rabbits from the age of 4 weeks Use the vaccine within 10 hours haemorrhagiae cuniculi for prevenon of mortality aer ﬁrst opening. inacvatum type 2 (RHDV 2) caused by the rabbit min. 80* haemorrhagic disease type 2 STORAGE * Titre of haemagglunaon inhibion virus (RHDV2). Store in a dark and dry place anbodies aer applicaon of the vaccine to at 2 – 8 °C. laboratory animals (rabbit) Onset of immunity: 7 days aer vaccinaon. Protect against freeze. Adjuvans: Aluminium hydroxide hydrous Duraon of immunity: P ACKAGE for adsorbon 2% 0.1 ml 6 months aer vaccinaon. 10 × 1 dose, 1 × 10 doses, Excipients: AMOUNTS TO BE 10 × 10 doses, 1 × 20 doses, Thiomersal 0.05 mg ADMINISTRATED AND 10 × 20 doses ADMINISTRATION ROUTE TARGET SPECIES Dose 0,5ml regardless of animal Rabbits. size. Administraon: subcutaneously.

85 6 Rabbit vaccines

Protecon against RHD and myxomatosis in one shot

PESTORIN MORMYX lyophilisate and solvent for suspension for injecon Vaccine against Rabbit Haemorrhagic Disease and myxomatosis

COMPOSITION a) Vaccinaon with AMOUNTS TO BE Acve substances in one dose: the monovalent vaccine against ADMINISTERED AND Liquid component: Calicivirus myxomatosis (Myxoren) can be ADMINISTRATION ROUTE sepcemiae haemorrhagiae performed at the age of 4 weeks Dose: 1 ml regardless cuniculi (soluo organorum) – and above followed with of animal size. min. 80*, aluminium hydroxide, the revaccinaon with the Administraon: subcutaneously. thiomersal, buﬀered saline vaccine Pestorin Mormyx that SHELF LIFE soluon. shall be applied not earlier than 24 months *Titre of hemagglunaon inhibion at the age of 10 weeks. The anbodies following vaccinaon of Use the vaccine within 2 hours laboratory animals (rabbit) interval of at least 2 weeks shall mixing the components! be kept between the applicaons Lyophilized component: Poxvirus of the vaccines Myxoren and STORAGE myxomatosae aenuatum – Pestorin Mormyx. Store in a dry and dark place min. 103,3 – max. 10 5,8TCID , 50 b) Vaccinaon with the vaccine at 2 to 8 °C. The vaccine culvaon medium MEM, Pestorin Mormyx can be do not freeze! lyophilizaon medium. performed at the age of 6 weeks PACKAGE Soluon for injecon. and above followed by 1 × 1, 5 × 1, 10 × 1 dose For rabbits the revaccinaon performed 1 × 5, 5 × 5, 10 × 5, 1 × 10 dose INDICATIONS 4 weeks later. 5 × 10, 10 × 10 dose. For the prevenve immunizaon Next revaccinaons with of clinically healthy rabbits the vaccine Pestorin Mormyx is against rabbit haemorrhagic recommended to be performed disease and myxomatosis. in 6-month intervals in breeding Rabbits should be vaccinated animals. Considering the disease at the age of 10 weeks. seasonal incidence, animals Vaccinaon can be performed should be vaccinated earlier in case of adverse (re-vaccinated) in me to ensure infecous condions, namely, their full immunity during the as follows: whole crical period of infecon occurrence.

86 6 Rabbit vaccines

For protecon of animals in large rabbits farms against dermatophytosis

TRICHOPELEN lyophilisate for suspension for injecon with solvent Vaccine against trichophytosis in fur-bearing animals

COMPOSITION Silver foxes, artcc foxes and SHELF LIFE Acve substance in one dose: rabbits aged 6 weeks and above: 18 months. The reconstuted Trichophyton mentagrophytes Prophylacc doses: vaccine shall be consumed within min. 2 × 105 CFU, 2 × 0.5 ml of the vaccine 2 hours. 6 max. 8 × 10 CFU Therapeuc doses: STORAGE Solvent 2 × 1 ml of the vaccine Store and transport refrigerated Diluent A 1 ml Chinchillas: (2 °C – 8 °C). Do not freeze. Lyophilisate for suspension Prophylacc doses: Protect from light. Store in a dry for injecon with solvent animals aged 2–3 months place. TARGET SPECIES 2 × 0.25 ml animals aged 3 months PACKAGE Silver foxes, arcc foxes, rabbits, 1 × 1 ml + Diluent A, chinchillas. and above 2 × 0.5 ml Therapeuc doses: 2 × 0.5 ml 5 × 1 ml + 5 × Diluent A, INDICATION The interval between vaccinaon 5 × 10 ml + 5 × Diluent A, Prophylaxis and therapy and revaccinaon is in broiler 1 × 50 ml + Diluent A of trichophytosis in fur-bearing rabbits aged 14 days to 6 weeks animals. 5–12 days, for other animals DOSAGE 8–12 days. The preparaon should be WITHDRAWAL PERIODS applied intramuscularly in Meat 6 weeks. a lumbar or gluteal region. Broiler rabbits aged 14 days to 6 weeks: Prophylacc doses: 2 × 0.25 ml Therapeuc doses: 2 × 0.25 ml

87 88 SWINE

VACCINES

BIOSUIS APP 2,9,11 BIOSUIS M.hyo BIOSUIS PARVO L (6) BIOSUIS ParvoEry BIOSUIS PRRS inact Eu+Am BIOSUIS Respi E ERYPESTEN ERYSEN ERYSIN SINGLE SHOT KOLIERYSIN Neo KOLISIN Neo PARVOERYSIN PARVOSIN-OL PESTISEN-C POLYPLEUROSIN APX PLUS IM RHINISIN DNT 7 ROKOVAC NEO 7 Swine vaccines

Inacvated vaccine against Acnobacillosis of pigs caused by dangerous serotypes 2,9,11 with toxoids APX I, II and III with the dose 1 ml only

BIOSUIS APP 2,9,11 emulsion for injecon for pigs

COMPOSITION INDICATION SHELF LIFE Acnobacillus pleuropneumoniae For acve immunisaon Shelf life of the veterinary serovar 2 RP ≥ 1* of faening pigs to migate medicinal product in intact Acnobacillus pleuropneumoniae the consequences of infecon package 2 years and aer the first serovars 9, 11 RP ≥ 1* caused by Acnobacillus opening of the immediate toxoid APX I RP ≥ 1* pleuropneumoniae – the cause packaging 10 hours. toxoid APX II RP ≥ 1* of porcine pleuropneumonia. STORAGE toxoid APX III RP ≥ 1* DOSAGE, ROUTE OF Store in a refrigerator The vaccine contains inacvated ADMINISTRATION AND (2 °C – 8 °C). Do not freeze. whole-cell angens of VACCINATION SCHEME PACKAGE Acnobacillus pleuropneumoniae Dosage: piglets from the age s.2, s.9 and s.11 and toxoids APX 10 ml, 50 ml, 100 ml, 250 ml of 6 weeks are vaccinated with a in glass or plasc bole. I, APX II and APX III. These dose of 1,0 ml angens aer parenteral Applicaon: intramuscularly, administraon cause producon preferably to the paraauricular of specific anbodies, which area. help to protect against the The onset of acve immunity consequences of field infecon 3 weeks aer revaccinaon and by Acnobacillus the duraon of immunity pleuropneumoniae. 20 weeks aer revaccinaon. TARGET SPECIES Pigs.

90 7 Swine vaccines

Inacvated vaccine against Enzooc Pneumonia (Mycoplasmosis) of pigs with the possibility to use only one dose aer 10 days of age

BIOSUIS M.hyo emulsion for injecon for pigs

COMPOSITION DOSAGE, ROUTE OF SHELF LIFE Acve substance: ADMINISTRATION AND Shelf life of the veterinary Inacvated VACCINATION SCHEME medicinal product in intact Mycoplasma Dosage: 2 ml package 2 years and aer the first hyopneumoniae RP ≥ 1* Applicaon: intramuscularly, opening of the immediate TARGET SPECIES preferably to the paraauricular packaging 10 hours. Pigs. area. STORAGE The vaccine should be INDICATION Store in a refrigerator administered according to the (2 °C – 8 °C). Do not freeze. For acve immunizaon of following schemes: faening pigs to migate 1) 1 dose should be administered PACKAGE the effects of infecon with to piglets aer 10 days of age. 10 ml, 100 ml, 250 ml in glass Mycoplasma hyopneumoniae – 2) In the farms with high infecon or plasc bole. a causave agent of enzooc pressure by Mycoplasma pneumonia in pigs. hyopneumoniae 2 doses at an interval of 3 weeks can be administered from 7 days of age. Selecon of the vaccinaon scheme depends on knowing the disease incidence on a parcular farm.The product smulates acve immunity against Mycoplasma hyopneumoniae, thus migang the effects of infecon with M. hyopneumoniae in faening pigs.

91 7 Swine vaccines

Inacvated vaccine against Porcine Parvovirosis and all dangerous serotypes of leptospira including Leptospira pomona and Leptospira Braslava BIOSUIS PARVO L (6) emulsion for injecon for pigs

COMPOSITION INDICATION Vaccinaon 4–5 weeks prior Acve substance: For prevenve vaccinaon of to first mang or ejaculate Parvovirus suis inact. min. 512 HA sows, gilts and boars against collecon and in 2–3 weeks aer Leptospira pomona inact. porcine parvovirosis and lepto- vaccinaon a revaccinaon is min. 1 × 108 spirosis. The BIOSUIS PARVO L (6) performed so that it is Leptospira Hardjo inact. vaccine can be simultaneously accomplished 2–3 weeks prior to min. 1 × 108 administered with other first mang or inclusion of the Leptospira Braslava inact. inacvated vaccines from the boar to arficial inseminaon. To min. 1 × 108 product range of the Bioveta, a.s. maintain immunity, revaccinate Leptospira grippotyphosa inact. always with one vaccinaon dose 8 DOSAGE, ROUTE OF min. 1 × 10 ADMINISTRATION AND within 6 months. Leptospira icterohaemorrhagiae The maximal level of 8 VACCINATION SCHEME inact. min. 1 × 10 Dosage: 2ml postvaccinaon anbodies is Leptospira canicola inact. detected 14 to 28 days aer 8 Applicaon: intramuscularly min. 1 × 10 1) Gilts and sows: revaccinaon and these Immunisaon induces producon Primovaccinaon – two vaccine anbodies persist for at least of specific anbodies that protect doses – vaccinaon and 6 months aer the vaccinaon. embryos and foetuses of gilts and revaccinaon. SHELF LIFE sows against parvovirosis and Vaccinaon 4–5 weeks prior to Shelf life of the veterinary leptospirosis for the whole period covering and in 2–3 weeks aer medicinal product in intact of pregnancy. vaccinaon is revaccinaon package 2 years and aer the first The high tres of post- performed so that it is opening of the immediate vaccinaon anbodies in boars accomplished 2–3 weeks prior packaging 10 hours. prevent parvovirus and leptospira to mang. STORAGE replicaon in the genitals and Further regular vaccinaons reduce the risk of infecon Store in a refrigerator always with one vaccinaon dose (2 °C – 8 °C). Do not freeze. transmission during mang. 2–4 weeks prior to mang. TARGET SPECIES 2) Boars: PACKAGE Pigs. Primovaccinaon – two vaccine 4 ml, 10 ml, 20 ml, 50 ml, 100 ml, doses – vaccinaon and 250 ml, 500 ml in glass or plasc revaccinaon. bole.

92 7 Swine vaccines

Vaccine against Swine Parvovirosis and Swine Erysipelas with aluminium hydroxid adjuvant

BIOSUIS ParvoEry suspension for injecon for pigs Inacvated vaccine against Swine Parvovirosis and Swine Erysipelas

ACTIVE SUBSTANCE DOSAGE, ADMINISTRATION vaccinated as gilts (before first AND VACCINATION SCHEME farrowing), the primary vaccinaon Porcine parvovirus, inacvated, same as for gilts should be performed. strain CAPM V198, S-27 Dosage: 2 mlAdministraon: Other regular revaccinaon always ≥ 4 log2 *) intramuscularly into the neck with one vaccinaon dose 3 weeks Erysipelothrix rhusiopathiae muscles behind the ear before each inseminaon at the inacvated, serotype 2, strain 2- 1) Gilts: Primary vaccinaon – from 6 latest (but not later than 6 months 64 RP ≥ 1 **) months of age 2 vaccinaon doses in aer previous vaccinaon). The onset *) tre HI anbodies in guinea-pig serum aer the period of 6 weeks and 3 weeks of acve immunity against Parvovirus applicaon of ¼ dose for pigs. Anbodies tre 16 and before inseminaon. In case of suis 3 weeks aer primary vaccinaon more must be proved in 4 from 5 guinea-pigs. The resulng value of HI tre is given by mean of tres of previous vaccinaon against (beginning of pregnancy) and against anbodies reached in 5 guinea pigs.**) Relave parvovirus and erysipelas of pigs with E. rhusiopathia 3 weeks aer primary potency (RP) is given by comparison of anbody level in serum of vaccinated mice with anbody level in monovalent vaccines from Bioveta, a. vaccinaon. Duraon of immunity mice serum prepared with reference vaccine batch, s. producon, if available against Porcine parvovirus during the which complies in challenge test on target animals (administraon of 1 vaccinaon dose whole pregnancy period and against according to the Phr. Eur. requirements. against erysipelas from 8 weeks of age E. rhusiopathiae 6 months aer TARGET SPECIES and administraon of 1 vaccinaon primary vaccinaon. Pigs (gilts, sows) dose against porcine parvovirus SHELF LIFE 6 weeks before inseminaon), one INDICATION vaccinaon dose 3 weeks before Shelf life of the veterinary For acve immunisaon of pigs inseminaon is sufficient. medicinal product in intact (gilts, sows) to reduce clinical Other regular revaccinaon always package 2 years and aer the first signs (skin lesions and fever) of with one vaccinaon dose 3 weeks opening of the immediate Swine Erysipelas caused by before each inseminaon at the packaging 10 hours. latest (but not later than 6 months Erysipelothrix rhusiopathiae and aer previous vaccinaon). STORAGE to prevent transplacental 2) Sows: Primary vaccinaon - in case Store in a refrigerator infecon of embryos and of previous vaccinaon against (2 °C – 8 °C). Do not freeze. foetuses of gilts and sows caused parvovirus and erysipelas of pigs with Protect from light. by Porcine Parvovirus. vaccines from Bioveta, a.s. producon (see administraon schedule for gilts), PACKAGE one vaccinaon dose 3 weeks before 10ml, 50ml, 100ml, 250ml in inseminaon is sufficient. In case glass or plasc bole. when the sows were not previously

93 7 Swine vaccines

Inacvated vaccine against PRRS infecon combines both known European and American strains

BIOSUIS PRRS inact Eu+Am emulsion for injecon for pigs

COMPOSITION DOSAGE, ROUTE OF REVACCINATION: Acve substance: ADMINISTRATION AND Applicaon of 1 dose (2 ml) on Inacvated PRRS virus: VACCINATION SCHEME day 60–70 in each pregnancy PRRS/EU strain Dosage: 2 ml following the basic vaccinaon. 5.1 min. 10 TCID50  RP 1 Applicaon: intramuscularly The scope of immunizaon is at PRRS/US strain preferably to the paraauricular the discreon of a veterinary 5.1 min. 10 TCID50  RP 1 area. surgeon and depends also TARGET SPECIES The animals (gilts) may be on the specific epizooc Pigs (gilts and sows). vaccinated before mang from situaon. the age of 6 months. The onset of immunity was INDICATION Basic vaccinaon: demonstrated by challenge Acve immunizaon of gilts and 1) Gilts: 3 weeks aer the primary sows to reduce reproducve Primary vaccinaon 2×1 dose at vaccinaon (i.e. aer the disorders and viremia caused by an interval of 2–3 weeks, before administraon of three doses) porcine reproducve and mang, the third dose on day and the duraon of immunity respiratory syndrome virus 60–70 of gestaon following demonstrated by challenge was (European and American type). the primary vaccinaon. 6 months. In the herds infected with the 2) Sows: PRRS virus the infecon is of SHELF LIFE Primary vaccinaon 2×1 dose at Shelf life of the veterinary heterogeneous character and is an interval of 2–3 weeks, before manifested differently during medicinal product in intact mang, areal vaccinaon of sows package 18 months and aer the the me period. In this context, in the herd in the shortest the correctly applied vaccinaon first opening of the immediate possible me interval is packaging 10 hours. programme, together with recommended, the third dose the zoohygienic acons, is an on day 60–70 of gestaon STORAGE effecve tool for improvement following the primary Store in a refrigerator of reproducve indicators and vaccinaon. (2 °C – 8 °C). Do not freeze. for control of the disease. PACKAGE 10 ml, 50 ml, 100 ml in glass or plasc bole.

94 7 Swine vaccines

Inacvated combined vaccine against Acnobacillosis, all clinical forms of Swine Erysipelas and dangerous serotypes H.parasuis caused Glässer disease BIOSUIS Respi E emulsion for injecon for pigs

COMPOSITION DOSAGE, ROUTE OF Onset of acve immunity 21 days Acve substance: ADMINISTRATION AND aer revaccinaon and duraon Acnobacillus pleuropneumoniae VACCINATION SCHEME of acve imunity 20 weeks aer serovar 2 RP ≥ 1* Dosage: 1 ml (piglets) or 2 ml revaccinaon. Duraon of passive Acnobacillus pleuropneumoniae (pregnant gilts and sows) immunity for the suckling period serovars 9, 11 RP ≥ 1* Applicaon: intramuscularly (i.e. 3 weeks). Apx I toxoid RP ≥ 1* preferably to the paraauricular For acve immunizaon of sows Apx II toxoid RP ≥ 1* area. to prevent infecon with Apx III toxoid RP ≥ 1* 1) Piglets: erysipelas onset of immunity Erysipelothrix rhusiopathiae Primary vaccinaon with a dose 21 days aer revaccinaon and (3 strains - type 2, 1 strain - of 1 ml from 6 weeks of age and duraon of immunity 6 months type 1) RP ≥ 1* revaccinaon aer 3 weeks aer booster revaccinaon. Haemophilus parasuis 2) Sows: SHELF LIFE (serovars 1, 5, 13) RP ≥ 1* Inial vaccinaon with a dose Shelf life of the veterinary TARGET SPECIES 2 ml 6–5 weeks before medicinal product in intact Pigs (pregnant gilts, sows, farrowing and revaccinaon package 2 years and aer piglets). aer 2–3 weeks, but not later the ﬁrst opening of the than 2 weeks before farrowing immediate packaging 10 hours. INDICATION Booster revaccinaon with a dose For acve and passive 2 ml regularly 3–2 weeks before STORAGE immunizaon of piglets to each subsequent farrowing Store in a refrigerator prevent infecon with erysipelas, In the event that the period (2 °C – 8 °C). Do not freeze. reduce infecon with between two deliveries exceeds PACKAGE Acnobacillus pleuropneumoniae 6 months, it is necessary to 10 ml, 50 ml, 100 ml and 250 ml and Haemophilus parasuis perform again the inial in glass or plasc bole. (Glässer's disease) and to reduce vaccinaon and revaccinaon. clinical symptoms caused by these pathogens.

95 7 Swine vaccines

Live combined vaccine against Swine Erysipelas and Classical Swine Fever

ERYPESTEN inj. sicc. ad us. vet.

COMPOSITION Breeding pigs: SHELF LIFE Acve substance: Revaccinaon shall be carried out Shelf life of the veterinary Erysipelothrix rhusiopathiae - in pigs at the age of 5–6 month medicinal product in intact minimum 1 × 109 (before they are included package 18 months and Virus of pess in pigs, in a breeding-stock). the vaccine shall be consumed nonpatogenous – Its onset against classical swine within 3 hours aer being 5 minimum 10 PD50 fever can be observed 3th day dissolved. Lyophilized culture of the vivid aer the vaccinaon and the Note: The vaccine can be applied aenuated strain of erysipelas immunity is fully developed 7th intradermally by means of and nonpatogenous strain of day aer the vaccinaon. a needless injector during classical swine fever in pigs. The vaccine assures the whole- the mass examinaon. TARGET SPECIES life immunity against classical 5 × concentrated vaccine shall Pigs. swine fever. be used in such cases. Its onset against erysipelas be The lyophilizate supplied in 20 ml INDICATION observed 8th – 14th day aer vial (with 100 ml marking) shall For the basic imunizaon against the vaccinaon and it lasts be then diluted only in 20 ml of E erysipelas and pest. Pigs shall be for 6 months. Nevertheless, in diluent and 0.2 ml of vaccine shall vaccinated not early than at order to keep the immunity be applied into the skin the age of 8–9 weeks. against erysipelas, the in auricle base. DOSAGE, ROUTE OF revaccinaon with the vaccine STORAGE ADMINISTRATION AND against erysipelas shall be carried Store in a refrigerator VACCINATION SCHEME out every 6 months. (2 °C – 8 °C). Do not freeze. Dosage: 2 ml WITHDRAWAL PERIOD PACKAGE Applicaon: subcutaneously, Meat – 21 days. preferably to the paraauricular 20 ml and 100 ml area. with Diluent E. The ﬁrst vaccinaon: pigs over 8–9 weeks of age.

96 7 Swine vaccines

Live aenuated lyophilised vaccine against Swine Erysipelas from the age of 8 weeks

ERYSEN inj. sicc. ad us. vet.

COMPOSITION Lyophilizate dissoluon: 2) Pigs intended for breeding: Acve substance: For the intradermal applicaon Primary vaccinaon should Erysipelothrix rhusiopathiae of the vaccine the lyophilizate is be performed at the age aenuatum – at least 1 × 107, re-hydrated as follows: of 8–9 weeks (animals weighing culturing medium, lyophilizing - 20 ml packing (of the lyophilized 15–20 kg of body weight) and medium, diluent A. constuent) diluted in 4 ml of revaccinaon at the age of Diluent A – the dose 0.2 ml i.d. 5–6 months. TARGET SPECIES - 20 ml packing (of the lyophilized The revaccinaon should be Pigs. constuent) diluted in 2 ml of repeated always at the period INDICATION Diluent A – the dose 0.1 ml i.d. of 6 months. Immunizaon of pigs against - 100 ml packing (of the The immunity onset comes swine erysipelas with a single lyophilized constuent) diluted one day 8–14 following the vaccinaon dose only. in 20 ml of Diluent A – the dose vaccinaon and lasts DOSAGE, ROUTE OF 0.2 ml i.d. for 6 months. ADMINISTRATION AND - 100 ml packing (of the WITHDRAWAL PERIOD VACCINATION SCHEME lyophilized constuent) diluted Meat – 21 days. Subcutaneous: 2 ml in 10 ml of Diluent A – the dose 0.1 ml i.d. SHELF LIFE Lyophilizate dissoluon: Shelf life of the veterinary For the subcutaneous applicaon 1) Pigs intended for faening: Should be vaccinated at the age medicinal product in intact of the vaccine the lyophilizate is package 2 years and the vaccine re-hydrated with the full volume between 8 weeks and 9 weeks (animals weighing 15–20 kg of shall be consumed within 3 hours of the enclosed Diluent A. aer being dissolved. Intradermal: 0.1 ml or 0.2 ml body weight). The vaccine (depending on the dissoluon protects animals for the whole STORAGE of the lyophilizate when intended faening period. Store in a refrigerator for use in a needle-less (2 °C – 8 °C). Do not freeze. applicator). PACKAGE 20 ml and 100 ml with Diluent A.

97 7 Swine vaccines

Inacvated vaccine against all forms of Swine Erysipelas with a single vaccinaon dose only

ERYSIN SINGLE SHOT emulsion for injecon for pigs

COMPOSITION DOSAGE, ROUTE OF SHELF LIFE Acve substance: ADMINISTRATION AND Shelf life of the veterinary Erysipelothrix rhusiopathiae VACCINATION SCHEME medicinal product in intact inact. (3 strains – type 2, 1 strain Dosage: 2 ml package 18 months and aer – type 1) – min. 1 × 1010, Applicaon: subcutaneously, the ﬁrst opening of the nutrimentum ad culvaonem, preferably to the paraauricular immediate packaging 10 hours. emulsio olei, formalin, area. STORAGE merthiolate. The ﬁrst vaccinaon: pigs over Store in a refrigerator TARGET SPECIES 8 weeks of age. (2 °C – 8 °C). Do not freeze. Pigs. Breeding pigs: another vaccinaon and revaccinaon PACKAGE INDICATION always aer 6 months. 10 ml, 20 ml, 50 ml, 100 ml For immunizaon of pigs against Immunity is fully developed in glass or plasc bole. all of forms porcine erysipelas 21 days aer the vaccinaon and including sepcemic form too. persists for 6 months.

98 7 Swine vaccines

Inacvated combined vaccine against Neonatal Colibacillosis in suckling piglets and all forms of Swine Erysipelas

KOLIERYSIN NEO emulsion for injecon for pigs

COMPOSITION Basic vaccinaon: Piglets are protected against the Acve substance: Sows and gilts should be illness for the period of suckling Escherichia coli inacvata administered not later than from an immunized mother. (F4) RP  1 5 weeks before the expected The onset of the immunity Escherichia coli inacvata farrowing with the single dose against erysipelas comes within (F5) RP  1 of the vaccine KOLIERYSIN NEO. 21 days following the vaccinaon Escherichia coli inacvata In order to protect piglets against and lasts for 6 months. (F6) RP  1 enteric coli infecons (via the SHELF LIFE Escherichia coli inacvata colostric and lactogenic way by Shelf life of the veterinary (F41) RP  1 suckling from the immunized medicinal product in intact Erysipelothrix rhusiopathiae mother) the revaccinaon with package 18 months and aer inact. RP  1 the single dose of the vaccine the ﬁrst opening of the (3 strains – type 2,1 strain – KOLISIN NEO shall be performed immediate packaging 10 hours. type 1) 10–14 days later. This revaccinaon should be STORAGE TARGET SPECIES performed not later than 14 days Store in a refrigerator Gilts and pregnant sows. before the expected delivery. (2 °C – 8 °C). Do not freeze. INDICATION Revaccinaon: PACKAGE For the protecon against Shall be repeated 2–3 weeks 5 ml, 10 ml, 20 ml, 50 ml, 100 ml, erysipelas in sows, and against before the each next expected 250 ml, 500 ml in glass or plasc enteric coli-infecons in piglets. farrowing. bole. DOSAGE, ROUTE OF Aer being applied ADMINISTRATION AND intramuscularly into the body VACCINATION SCHEME of a vaccinated individual, Dosage: 2 ml the angens contained in the Applicaon: intramuscularly vaccine acvate the immunity preferably to the paraauricular system and anbody formaon. area.

99 7 Swine vaccines

Inacvated vaccine against Neonatal Colibacillosis of piglets containing frequent enterotoxigenic prevalent serovars of E. coli with LT thermola- bile enterotoxins producon KOLISIN NEO emulsion for injecon for pigs

COMPOSITION Basic vaccinaon: SHELF LIFE Acve substance: Should be applied to sows and Shelf life of the veterinary Escherichia coli inacvata gilts not later than 5 weeks medicinal product in intact (F4) RP  1 before the expected farrowing package 2 years and aer the ﬁrst Escherichia coli inacvata and revaccinaon 2–3 weeks opening of the immediate (F5) RP  1 later. packaging 10 hours. Escherichia coli inacvata Revaccinaon: STORAGE (F6) RP  1 Administraon of 1 injecon Store in a refrigerator Escherichia coli inacvata 4 to 2 weeks prior to any other (2 °C – 8 °C). Do not freeze. (F41) RP  1 expected farrowing. Two vaccinaons shall be again PACKAGE TARGET SPECIES performed if the interval 5 ml, 10 ml, 20 ml, 50 ml, 100 ml, Gilts and pregnant sows. between two subsequent 250 ml, 500 ml in glass or plasc INDICATION deliveries exceeds 8 months bole. For the vaccinaon of the Aer being applied pregnant sows to be performed intramuscularly into the body in breeding infected or of a vaccinated individual, threatened with enteric coli the angens contained in the infecons. vaccine acvate the immunity DOSAGE, ROUTE OF system and anbody formaon. ADMINISTRATION AND Piglets are protected against the VACCINATION SCHEME illness for the period of suckling Dosage: 2 ml from an immunized mother. Applicaon: intramuscularly Piglets are not vaccinated (their preferably to the paraauricular protecon is ensured by the area. colostral and lactogenic way from the immunized mother).

100 7 Swine vaccines

Inacvated combined vaccine against Porcine Parvovirosis and all forms of Swine Erysipelas with possibility to use for primary vaccinaons one dose only

PARVOERYSIN emulsion for injecon for pigs

COMPOSITION DOSAGE, ROUTE OF Immunity against swine Acve substance: ADMINISTRATION AND erysipelas is developed fully Parvovirus suis inact.  4 log2 VACCINATION SCHEME 21 days aer vaccinaon and Erysipelothrix rhusiopathiae Dosage: 2 ml. lasts for 6 months. inact. RP  1 Applicaon: intramuscularly SHELF LIFE (3 strains of type 2, 1 strain 1) Gilts and sows: Shelf life of the veterinary of type 1) Primovaccinaon: medicinal product in intact Specific anbodies protecng One vaccinaon dose 2–4 weeks package 18 months and aer immunized animals against swine before mang. the first opening of the erysipelas, and the embryos and Addional regular vaccinaons immediate packaging 10 hours. foetuses of the sows and gilts are always with one vaccinaon STORAGE against parvovirosis throughout dose 2–4 weeks prior to mang. Store in a refrigerator pregnancy are formed aer the 2) Boars: (2 °C – 8 °C). Do not freeze. vaccinaon. In boars, high tres Primovaccinaon – one of anbodies prevent the vaccinaon dose at least 2 weeks PACKAGE replicaon of parvovirus in prior to mang. 10 ml, 20 ml, 50 ml, 100 ml the reproducve organs, thus To maintain immunity, in glass or plasc bole. decreasing the risk of infecon revaccinate always with one during mang or arficial vaccinaon dose within inseminaon. 6 months. TARGET SPECIES Aer primary vaccinaon, the Pigs. tres of haemagglunaon- inhibion anbodies show the INDICATION increase. Their maximum level is For the acve immunizaon detected on the 35th day, and of pigs against parvovirosis and the anbodies menoned are all forms of swine erysipelas protecve for a period including sepcemic form too. of 6 months.

101 7 Swine vaccines

Inacvated monovalent vaccine against Porcine Parvovirosis with possibility to use for primary vaccinaons one dose only

PARVOSIN-OL emulsion for injecon for pigs

COMPOSITION 1) Gilts and sows: SHELF LIFE Acve substance: Primovaccinaon: Shelf life of the veterinary Parvovirus suis inact. One vaccinaon dose 2–4 weeks medicinal product in intact ≥ 4 log2 before mang. package 2 years and aer the ﬁrst Vaccinaon induces producon Addional regular vaccinaons opening of the immediate of speciﬁc anbodies that protect are always with one vaccinaon packaging 10 hours. embryos and foetuses of gilts and dose 2–4 weeks prior to mang. STORAGE sows against parvovirosis for the 2) Boars: Store in a refrigerator whole pregnancy period. Primovaccinaon – one (2 °C – 8 °C). Do not freeze. In boars the high tres of vaccinaon dose at least 2 weeks anbodies prevent parvovirus prior to mang. PACKAGE replicaon in the genitals and To maintain immunity, 10 ml, 20 ml, 50 ml, 100 ml, reduce the risk of infecon revaccinate always with one 250 ml, 500 ml in glass or plasc transmission during mang. vaccinaon dose within bole. TARGET SPECIES 6 months. Pigs (gilts, sows, boars). The tre of haemagglunaon inhibion anbodies rises INDICATION following primovaccinaon. For prevenve vaccinaon The maximum level is of sows, gilts and boars against determined on the 35th day porcine parvovirosis. and the anbodies persist DOSAGE, ROUTE OF for 6 months. ADMINISTRATION AND VACCINATION SCHEME Dosage: 2 ml Applicaon: intramuscularly

102 7 Swine vaccines

Live aenuated vaccine against Classical Swine Fever (CSF) for all categories of pigs

PESTISEN-C inj. sicc. ad us. vet.

COMPOSITION immunity – at the age of 8 weeks. included in the faening group. Acve substance: Live aenuated Said single vaccinaon provides Its onset against classical swine swine pest virus (C strain-China) immunity for the whole faening fever can be observed 3th day

min. 100 PD50, max. 1000 PD50 course. aer the vaccinaon and the TARGET SPECIES Pigs intended for breeding (both immunity is fully developed 7th Pigs. sows and boars) coming from day aer the vaccinaon. sows that were vaccinated with The vaccine assures the whole- INDICATION PESTISEN-C vaccine should life immunity against classical The vaccine is intended also be vaccinated at the age swine fever. Piglets coming from for prevenve vaccinaon of of 8 weeks and re-vaccinated at sows that were vaccinated with pigs against classical swine fever. the age of 6–8 months (but not PESTISEN are protected for DOSAGE, ROUTE OF later than 1 month before their 5–7 weeks due to colostral ADMINISTRATION AND pung). immunity. VACCINATION SCHEME Pigs coming from mothers that SHELF LIFE Dosage: 2 ml were not vaccinated against pest Shelf life of the veterinary Applicaon: subcutaneously, in pigs should be vaccinated medicinal product in intact preferably to the paraauricular in the same way. package 18 months and area. 2) Vaccinaon carried out in the vaccine shall be consumed 1) Prevenve vaccinaon: breeding aﬀected or infected within 3 hours aer being It is used for the vaccinaon with CSF: dissolved. of healthy pigs intended for PESTISEN-C vaccine can be Note: The vaccine can be applied intradermally breeding and faening. applied – with regard to the quick by means of a needless injector during the mass In the large-scale breeding and immunity onset – also in examinaon. 5x concentrated vaccine shall be used in such cases. The lyophilizate supplied in faening farms, all pigs shall be breeding that are at risk of being 20 ml vial (with 100 ml marking) shall be then vaccinated consecuvely in the infected or are already infected diluted only in 20 ml of E diluent and 0.2 ml of vaccine shall be applied into the skin in auricle relevant rounds. Fodder type with CSF in pigs. In this case, pigs base. shall not be changed during the that do not show any symptoms STORAGE vaccinaon period. of CSF in pigs (without fever) Store in a refrigerator Pigs intended for faening and should be vaccinated at the age (2 °C – 8 °C). Do not freeze. coming from sows that were of 1 week and above. vaccinated with PESTISEN-C Piglets vaccinated at the age PACKAGE vaccine should be vaccinated – of 1–7 weeks should be 20 ml and 100 ml with Diluent E. because of their colostral revaccinated before they are

103 7 Swine vaccines

Inacvated subunit bacterin-toxoid vaccine against bacterial respiratory syndrome of pigs with the dose 1 ml only

POLYPLEUROSIN APX PLUS IM emulsion for injecon for pigs

COMPOSITION DOSAGE, ROUTE OF SHELF LIFE Acve substance: ADMINISTRATION AND Shelf life of the veterinary Acnobacillus pleuropneumoniae VACCINATION SCHEME medicinal product in intact serotype 9 RP> 1* Dosage: 1 ml package 18 months and aer the Acnobacillus pleuropneumoniae Applicaon: intramuscularly, ﬁrst opening of the immediate serotype 2 RP> 1* preferably to the paraauricular packaging 10 hours. Pasteurella multocida area. STORAGE serotype A RP> 1 * 1) Pigs: Store in a refrigerator Pasteurella multocida Primary vaccinaon with a dose (2 °C – 8 °C). Do not freeze. serotype D RP> 1 * of 1 ml from 6 weeks of age and Bordetella bronchisepca RP> 1* revaccinaon aer 3 weeks PACKAGE Apx I toxoid RP> 1* 2) Pregnant gilts and sows: 10 ml, 20 ml, 50 ml, 100 ml, Apx II toxoid RP> 1* Inial vaccinaon: 250 ml, 500 ml in glass or plasc Apx III toxoid RP> 1* With a dose 1 ml 6–4 weeks bole. TARGET SPECIES before farrowing and Pigs. revaccinaon aer 2–3 weeks, but not later than 2 weeks before INDICATION farrowing For immunizaon of piglets, pregnant gilts and sows in Revaccinaon: healthy herds or suﬀering Administraon of 1 injecon from pneumonia caused by: 3 to 2 weeks prior to any other Acnobacillus pleuropneumoniae, expected farrowing. Pasteurella multocida, Bordetella Newborn piglets from vaccinated bronchisepca. sows receive passive protecon against pneumonia by colostral immunity for 14–21 days. Immunity is developed in 14 days aer revaccinaon and persists for 6 months.

104 7 Swine vaccines

Inacvated vaccine against porcine Progressive Atrophic Rhinis with dermonecrotoxical toxoid

RHINISIN DNT emulsion for injecon for pigs

COMPOSITION Basic vaccinaon: SHELF LIFE Acve substance: Breed sows and gilts are Shelf life of the veterinary Pasteurella multocida vaccinated with one dose medicinal product in intact type D – dermonecrotoxical 8–6 weeks before farrowing package 18 months and aer toxoid min. 2 μg and revaccinaon aer 4 weeks. the ﬁrst opening of the Bordetella bronchisepca – Further revaccinaon is carried immediate packaging cell suspension inacvata out with one dose 3 to 2 weeks 24 hours. 10 min. 10 microorganisms before each expected farrowing. STORAGE Pasteurella multocida – If the period between the two Store in a refrigerator cell suspension inacvata subsequent farrowings exceeds (2 °C – 8 °C). Do not freeze. min. 1010 microorganisms 8 months, it is necessary to repeat the basic vaccinaon. PACKAGE TARGET SPECIES 20 ml, 50 ml, 100 ml in glass Pigs older than 6 monts Piglets of immunized sows are passively protected against bole. INDICATION atrophic rhinis by the transfer To vaccinate gilts and sows so of maternal anbodies with that passive immunity against colostrum. The speciﬁc immunity atrophic rhinis can develop protecon develops between in newborn piglets. the 14th and 21st day aer basic The preparaon is intended vaccinaon. for prophylacc purposes. DOSAGE, ROUTE OF ADMINISTRATION AND VACCINATION SCHEME Dosage: 2 ml. Applicaon: intramuscularly, preferably to the paraauricular area.

105 7 Swine vaccines

Inacvated unique vaccine against rotaviral and enteric coliinfecons of piglets containing the most frequent enterotoxigenic prevalent serovars of E. coli ROKOVAC NEO emulsion for injecon for pigs

COMPOSITION DOSAGE, ROUTE OF SHELF LIFE Acve substance: ADMINISTRATION AND Shelf life of the veterinary Rotavirus suis inact. OSU 6 VACCINATION SCHEME medicinal product in intact RP ≥ 1* Dosage: 2 ml package 2 years and aer the ﬁrst Escherichia coli inact. Applicaon: intramuscularly opening of the immediate O101:K99 (F5) RP ≥ 1* preferably to the paraauricular packaging 10 hours. Escherichia coli inact. area. STORAGE O147:K88 (F4) RP ≥ 1* Basic vaccinaon: Store in a refrigerator Escherichia coli inact. Sows and gilts – administraon (2 °C – 8 °C). Do not freeze. O149:K88 (F4) RP ≥ 1* of 2 injecons within an interval Escherichia coli inact. of 2 to 4 weeks; the second PACKAGE K85:987P (F6) RP ≥ 1* injecon at the latest 2 weeks 10 ml, 50 ml, 100 ml, 250 ml Escherichia coli inact. prior to the expected farrowing. in glass or plasc bole. O101:K99:F41 (F5, F41) RP ≥ 1* Revaccinaon: TARGET SPECIES Administraon of one injecon Pigs (pregnant sows and gilts) 4 to 2 weeks prior to any other expected farrowing. INDICATION Vaccinated sows transfer colostral For acve immunisaon immunity to piglets, which are of pregnant sows and gilts thereby protected against against rotaviral and enteral angens contained in the vaccine coliinfecons, to induce colostral for the period of sucking from and lactogenous immunity to the vaccinated mother. protect piglets unll weaning. Piglets are protected against angens included in vaccine during sucking from vaccinated mother.

106 OTHER

VACCINES

8 LYSVULPEN 8 Other vaccines

Oral live aenuated vaccine for prophylacc vaccinaon of wild red foxes and racoon dogs against rabies

LYSVULPEN vaccine against rabies for oral immunisaon

COMPOSITION carefully dropped on the ground. PACKAGING 1 dose (1.8 ml): The bait is placed to the sites The vaccine is filled into the Acve ingredients: protected against direct sunlight aluminium-plasc blisters placed Aenuated strain of the rabies and aer placement, it is covered in the bait. virus SAD Bern composed of two with natural material (leaves, Package size: dominant subpopulaons of grass, plant lier, etc.) to protect a) For manual placement virus, namely SAD Bern and from sun. Vaccine (aluminium-plasc blister SAD B19 “like” In case that there is a direct with vaccine virus in the bait) is 6 min. 1.8×10 TCID50 – contact of the person's hand with packed into cardboard box with 8 max. 1.8×10 TCID50 the bait, it is necessary to use the fixaon grid with 20 pieces TARGET SPECIES protecve gloves during bait of baits. Red fox (Vulpes vulpes), racoon placement, so that the baits were Group packaging in a cardboard dog (Nyctereutes procyonoides). not affected by human smell. box is 30×20 doses Gloves are intended for single use (i.e. 600 doses). INDICATIONS only (for placement of 1 carton = b) For aerial distribuon For prophylacc vaccinaon of 20 pieces of baits). Vaccine (aluminium-plasc blister wild red foxes and racoon dogs with vaccine virus in the bait) is against rabies. SHELF LIFE Shelf life of the veterinary packed as follows: SPECIAL PRECAUTIONS medicinal product as packaged - by 40 doses freely in layers The vaccine must not be exposed for sale: 2 years. interleaved with tapaten in to temperatures above 15–25 °C Shelf life aer defrosng: thermo-isolaon cardboard box (carry in thermo-suitcases, max. 7 days at 25 °C. in the total amount of 400 doses possibly packaged to thermo- - in polyethylene containers in isolaon material, so that vaccine STORAGE amount 350, 400, 500, 600, 700, was sufficiently protected against Store and transport frozen at a 800, 900 and 1000 doses in the effects of higher temperature -20 °C or lower. thermo-isolaon cardboard box environmental temperatures) Protect from light. Approved Package Insert is a part unl the me of placement, The baits must be distributed and of every package. whether manual or from a plane. placed as soon as possible aer During manual placement in the defrosng. terrain, the bait in carton box is

108 HORMONES

LECIRELIN Bioveta 0.025 mg/ml OESTROPHAN 0.25 mg/ml OXYTOCIN BIO 5 IU/ml REMOPHAN 75 μg/ml SERGON 500 IU/ml 9 SERGON PG 400/200 IU 9 Hormones

Synthec GnRH as a luteinizing releasing hormone (LHRH) superanalogue with a high biological acvity and a prolonged eﬀect

LECIRELIN Bioveta 0.025 mg/ml soluon for injecon

COMPOSITION DOSAGE SHELF LIFE Acve substance: Making the date of ovulaon Shelf life of the veterinary Lecirelin 0.025 mg more precise, estrus medicinal product as packaged Excipients: synchronizaon, improving for sale: 2 years. Chlorobutanol the concepon rate aer 10 ml injecon vial: Shelf life hemihydrate 2.105 mg inseminaon, treatment of aer ﬁrst opening the immediate TARGET SPECIES irregular cycles: packaging: 28 days. Cows. 2 ml of the product, equivalent 2 ml ampoule: The product is to 50 µg of the acve intended for immediate INDICATIONS FOR USE, substance. consumpon aer ﬁrst opening. SPECIFYING THE TARGET SPECIES Treatment of ovarian cysts: STORAGE Making the date of ovulaon 4 ml of the product, equivalent to Protect from light. Protect from more precise, estrus 100 µg of the acve substance. frost. synchronizaon, improving WITHDRAWAL PERIODS PACKAGE the concepon rate aer Meat: Not applicable. 10 × 2 ml, 1 × 10 ml, 10 × 10 ml inseminaon, treatment Milk: Not applicable. of irregular cycles. Treatment of ovarian cysts. USE DURING PREGNANCY AND LACTATION Do not use during pregnancy. The product can be used during lactaon.

110 9 Hormones

Long me veriﬁed hormonal product. Substance contains cloprostenol with a analogous funcon as prostaglandin F2 alfa. Good safety margin and inﬂuence to ferlity. OESTROPHAN 0.25 mg/ml injecon soluon

COMPOSITION DOSAGE administraon follows on day 11, Cloprostenolum 1 ml of soluon Synchronizaon of heat inseminaon on day 14 and re- contains cloprostenolum Cale: administer 2 ml of the inseminaon on day 15. (ut natrium) 0.25 mg product (500 µg of the acve Pregnancy interrupon INDICATION substance) twice, 10 days apart. Cale: 2 ml of the product Biotechnical The first dose of the product (further treatment according to Cale – synchronizaon and should be administered at any the clinical condion); inducon of estrus in heifers and phase of the sexual cycle (in cows Sows: 0.7 ml pro toto (0.175 mg cows; within a period of 40 to 60 days of the acve substance) should Sows – inducon of parturion; aer calving). The second dose be administered starng from Mares – interrupon of normal should be administered on day 11 day 111 of pregnancy. The and pathological pregnancy aer the first administraon, with majority of cases of parturion (in the first half of gravidity) inseminaon being carried out on induced occur within 40 hours Therapeuc day 14 (72–76 hours aer the aer the administraon, namely Funconal disorders of ovaries, second administraon) between 24 and 35 hours. postpartal and post-service irrespecve of manifestaons Mares: a single dose of 1.0 ml anestrus (in heifers: silent estrus, of estrus, and subsequent (0.250 mg of the acve persisng diestrus, embryonal re-inseminaon (day 15). substance); on cycling mares mortality, lactaon anestrus, Funconal disorders of ovaries METHOD OF ADMINISTRATION terminaon of Cale: administer 2 ml of the Cale: Intramuscularly. pseudopregnancy), postpuerperal product; inseminaon is to be Sows, mares: Intramuscularly. performed aer the first estrus. chronical endometris, WITHDRAWAL PERIOD pyometra, interrupon of normal Follicular cysts are treated with a single dose of 2 ml, not earlier Meat – 24 hours, milk – no or pathological pregnancy in the withdrawal periods. first half of pregnancy, therapy of than on day 10 aer luteal cysts, combined therapy of administraon of HCG or LHRH, STORAGE follicular cysts, inducon of and aer a posive ovarian Store below 25 °C. parturion. response has been ascertained. Protect from light! The estrus occurs on day 3 aer SHELF LIFE TARGET SPECIES Oestrophan administraon. Cows, sows, mares. 36 months, aer first opening the Postpuerperal diseases of the 10 ml container: 28 days. uterus: Cale: administer 2 ml PACKAGE of the product, repeated 10 × 2 ml, 1 × 10 ml. 111 9 Hormones

Medicament for eﬀecve management of the dystocia, puerperal complicaons and milk producon disorders in target species

OXYTOCIN BIO 5 IU/ml injecon soluon

COMPOSITION DOSAGE STORAGE 1 ml of the product contains Cows Keep out of the reach and sight oxytocinum 5.0 IU Uterine inera, milk ejecon, of children. Store in a refrigerator INDICATION mass, uterine involuon: (2 °C – 8 °C).Protect from frost. To support parturion in case of 20–40 IU (i.m. or s.c.), SHELF LIFE primary and secondary expulsion 2.5–10 IU (i.v.). Shelf-life24 months, aer ﬁrst of fetus and to accelerate the Mares opening the container 28 days. expulsion of fetus. Uterine inera: 20–40 IU (i.m. or s.c.), 2.5–10 IU (i.v.). PACKAGE During the puerperal period 1 × 10 ml, 5 × 10 ml, 10 × 10 ml, (not lather then 3 day aer Placenta retenon: 10–20 IU (i.m. or s.c.). 1 × 20 ml, 5 × 20 ml, 10 × 20 ml, parturion): uterine inera: To 1 × 50 ml, 12 × 50 ml, 24 × 50 ml. smulate involuon in case of Milk ejecon, uterine involuon: placenta retenon and uterine 40 IU (i.m. or s.c.), 10 IU (i.v.) prolapse (the product is Sheep, goats administered immediately aer Uterine inera: 10 IU (i.m. delivery or caesarean secon and or s.c.), 0.5–2.5 IU (i.v.). two to four hours later), to Milk ejecon, uterine involuon: remove the pathological contents 10–20 IU (i.m. or s.c.), of uterus, endometris, 0.5–2.5 IU (i.v.). lochiometra. Sows Retenon of milk to smulate its Uterine inera, uterine ejecon in all target species. To involuon, placenta retenon, remove residual milk and toxic milk ejecon: material from the udder aer 10–30 IU (i.m. or s.c.), delivery and during the 0.5–2.5 IU (i.v.). treatment of infecous mass in Bitches cows. Uterine inera, uterine involuon, placenta retenon, TARGET SPECIES milk ejecon 2–10 IU (i.m. Cows, mares, sheep, goats, sows, or s.c.), 0.5 IU (i.v.) bitches.

112 9 Hormones

Hormonal product intended for synchronizing of sexual cycle of donors and recipients in the programme of bovine embryotransfer mainly REMOPHAN 75 μg/ml injecon soluon (ESTROPUR)

COMPOSITION DOSAGE When treang postpuerperal 1 ml of injecon soluon contains Cale: diseases of uterus, repeat the Dexcloprostenolum natricum 75 1) oestrus synchronizing – administraon at intervals μg administer 2 ml of the product of 10 days, inseminate solely Product´s acve substance is (0.15 mg of acve substance). aer the second administraon. dexcloprostenol sodium salt. This For estrus synchronisaon, ﬁrst Sows: substance is bioequivalent to determine the corpus luteum Administer (behind the ear)

F2-alpha prostaglandin, which has (6th to 18th day of the cycle) and a one-shot dose of 1 ml of a specific luteolyc effect. based on the developing oestrus preparaon (75 μg of acve TARGET SPECIES signs, inseminate 70 to 120 hours substance) from the 111th day Cows, heifers, sows. aer administraon. If oestrum of pregnancy. Most induced does not develop, the parturion start between the INDICATIONS preparaon may be administered 19th and 30th hour aer Biotechnical again on the 11th day aer the administraon. Cale – synchronizaon and first treatment. In embryo METHOD OF ADMINISTRATION inducon of estrus in heifers and donors, administer the 3rd day cows and synchronizing of Cale: intramuscularly. aer the superovulaon Sows, mares: intramuscularly. sexual cycle of donors and preparaon start (morning dose recipients in the programme 2 ml, evening dose 2 ml). When WITHDRAWAL PERIODS of bovine embryotransfer. treang funconal ovary Meat – 24 hours, milk – 4 hours Sows – synchronizaon and disorders, inseminate at the first SHELF LIFE inducon of parturion; oestrus provoked by the Shelf-life 2 years, aer first Therapeuc preparaon administraon; opening 14 days. Funconal disorders of ovaries, if oestrus does not appear, postpartum and post-service STORAGE it is possible to repeat the Store in a dry place at the anestrus, postpuerperal chronical administraon on the 11th day. endometris, pyometra, temperatures of 10 to 25 °C. 2) follicular cysts – at combined Protect from light. interrupon of either normal therapy administrate product on PACKAGE or pathological pregnancy in the 10th to 14th day aer LHRH 10 × 2 ml, 10 × 4 ml, 1 × 10 ml, the first half of pregnancy, administraon based on posive 5 × 10 ml, 5 × 20 ml. combined therapy of follicular ovarian response detecon. cysts, inducon of parturion.

113 9 Hormones

Follicle smulang hormone product intended for females of all farm and domesc animals except for mares

SERGON 500 IU/ml powder for preparaon of injecon soluon with solvent

COMPOSITION synchronizaon of estrus. WITHDRAWAL PERIOD(S) 1 ml of injecon soluon contains DOSAGE Meat and milk not applicable. Gonadotrophinum sericum Cows, heifers: 1000–3000 IU SHELF LIFE equinum – 500 IU Sheep, goats: 500 IU (suitable Shelf-life 2 years, aer diluon Serum gonadotropin smulates immediately aer removing of or re-constuon as instructed: ovaries, induces growth and intra-vaginal tampons) 24 hours. development of follicles and Sows: 500–1000 IU STORAGE controls producon of estrone – inducon of cycle and hormone. Store in a refrigerator. increasing of the number Protect from light. TARGET SPECIES of piglets per lier Cows, heifers, sows, gilts, sheep, (1. – 2nd day aer weaning) PACKAGE goat, bitch, rabbit. – quiet estrus 1 × 1000 IU + (10th day aer piglet weaning) 1 × Dissolvent à 2 ml INDICATIONS 5 × 1000 IU + Anestrus, inducon and Gilts: – anestrus and quiet estrus 5 × Dissolvent à 2 ml (from 8–10 months of age) 1 × 3000 IU + – estrus inducon (aged 1 × Dissolvent à 6 ml 6 months or 90 kg body weight) 5 × 3000 IU + Bitches: 250–500 IU 5 × Dissolvent à 6 ml Rabbit: 25–50 IU (inseminaon 1 × 5000 IU + 3rd and 5th day aer applicaon) 1 × Dissolvent à 10 ml 5 × 5000 IU + METHOD OF ADMINISTRATION 5 × Dissolvent à 10 ml Intramuscularly or subcutaneously

114 9 Hormones

Follicle smulang and luteinizing hormone product intended to inducing regular ferle estrus in sows and gilts

SERGON PG 400/200 IU lyophilizate for soluon for injecon with solvent

COMPOSITION DOSAGE AND METHOD OF ADMINISTRATION 1 ml of injecon soluon contains Transfer the content of the vial with the solvent to the vial with Gonadotropinum sericum the lyophilized substance and dissolve. Apply one dose (2 ml) equinum – 400 IU, Gonado- intramuscularly or subcutaneously behind the ear. tropinum chorionicum – 200 IU Applicaon scheme: The product is a lyophilized mixture of human chorionic Target species Indicaon Time of administraon gonadotropin (hCG) and Sow Starng the cycle Day 0 to 2 aer weaning pregnant mares' serum To increase the number of piglets Day 0 to 2 aer weaning gonadotropin (PMSG). Anestrus/subestrus Roughly Day 10 aer weaning Acng similarly to the follicle- Gilt Anestrus/subestrus At 8 to 10 months of age smulang hormone (FSH) and Inducon of oestrus At 5.5 to 6.5 months of age or at a the luteinizing hormone (LH), weight of 85 to 100 kg. Gilts can be the serum gonadotropin induces inseminated during the ﬁrst oestrus the growth of ovarian follicles. aer administraon. A more The chorionic gonadotropin acts numerous farrow can be expected if similarly to the luteinizing the inseminaon was only performed hormone and smulate ovulaon during the second oestrus aer administraon. and development of the corpus luteus. Combinaon of the Note: Oestrus will occur 3 to 6 days aer applicaon. hormones induces a ferle WITHDRAWAL PERIOD(S) PACKAGE oestrous cycle Meat and milk not applicable. 5×1 dose + 5×2 ml of the in pigs. SHELF LIFE diluents, 10×1 dose + 10×2 ml TARGET SPECIES Shelf-life 3 years, aer diluon of the diluents, 5×5 doses + Sows and gilts. or re-constuon as instructed: 5×10 ml of the diluent, INDICATIONS 12 hours. 5×10 doses + 5×20 ml of the Anestrus, inducon and diluent, 6×20 doses + 6×40 ml STORAGE synchronizaon of estrus of the diluent Store in a refrigerator. in sows and gilts. Protect from light.

115 116 10 Anmicrobial

ANTIMICROBIALS

AMOXICILLIN Bioveta 150 mg/ml LA BIOVETA AMOXICILIN 100 mg/g BIOVETA COLISTIN 1 200 000 IU/g COTRIMAZIN BIOVETA GAMMAVIT BIO IVATYL TAR 180.000 IU/ml 10 STREPTONAMID 10 Anmicrobial

Amoxicillin injectable anbiocs with a broad spectrum of acvity

AMOXICILLIN Bioveta 150 mg/ml LA suspension for injecon

COMPOSITION INDICATIONS SHELF LIFE Acve substance: Treatment of the disease caused Shelf-life of the veterinary Amoxicillinum (ut Amoxicillinum by the bacteria sensive to medicinal product in an intact trihydricum) 150 mg amoxicillin in cale, pigs and packaging for 2 years. Shelf life Excipients: dogs. Especially local, aer the ﬁrst opening of the Benzylalcohol (E 1519) 9 mg gastrointesnal, respiratory and immediate packaging: 28 days Butylhydroxytoluene urogenital infecons are STORAGE (E 321) 0.2 mg concerned. Store at a temperate below 25 °C. TARGET SPECIES DOSAGE Protect from light. Store in a dry Cale, pigs, dogs The usual dose is 10mg of place. amoxicillin per kg live body PACKAGE weight per day or 1ml per 15 kg 100 ml, 250ml live body weight per day. Route of administraon: intramuscular WITHDRAWAL PERIOD Meats: Cale: 15 days. Pigs: 42 days. Milk: 72 hours.

118 10 Anmicrobial

Water-soluble anbioc pulvis containing Amoxicillinum intended for pigs, poultry and calves

BIOVETA AMOXICILIN 100 mg/g powder for oral soluon

COMPOSITION DOSAGE Shelf-life in an intact package: 1 g of powder contains Oral administraon in drinking 2 years. Amoxicillinum (ut trihydricum) water. Shelf life aer reconstuon 100 mg 10 mg amoxicilin/1 kg of live in drinking water according to Anbioc powder for preparaon weight and day instrucon for use is 24 hours. of oral soluon. - 10 g of BIOVETA AMOXICILIN STORAGE TARGET SPECIES per 100 kg of live weight and day Store below 25 °C and keep in dry Poultry, pigs, cale – calves. (administer separately in two place. doses) or INDICATIONS - 0.5–2 g of BIOVETA PACKAGE Infecous diseases caused by AMOXICILIN per 1 litre of 100 g, 500 g, 1 kg, 3 kg, 5 kg. bacteria sensive to amoxicillin, drinking water for 5 days. In case such as e.g. upper respiratory of more serious infecon, it is tract infecon and infecon of possible to double the daily dose the lungs, postpartal infecons, on the ﬁrst day. infecon of the urogenital tract, Prepare the medicated drinking hepatobilliary infecon, water fresh every day. salmonelosis, coli infecons, etc. Amoxicilin is eﬀecve also during WITHDRAWAL PERIODS very low concentraons against Porcine meat for 3 days. bacteria from the group of Calf meat for 7 days. Streptococcus (including Poultry meat for 2 days. Streptococcus suis type-2) Do not administer to layers, Staphylococcus (including the eggs of which are intended penicillinase resistant strains), for human consumpon. Corynebacterium, Clostridium, SHELF LIFE Bacillus, Erysipelothrix, Campylobacter, Pasteurella, Escherichia, Salmonella, Serpulina, Bordetella and Acnobacillus.

119 10 Anmicrobial

Water-soluble bactericide anbioc pulvis containing Colisnum intended for pigs, domesc fowl and calves with high eﬀect against G– microorganisms

BIOVETA COLISTIN 1 200 000 IU/g powder for oral soluon

COMPOSITION DOSAGE WITHDRAWAL PERIODS 100 g of powder contains BIOVETA COLISTIN is Meat from piglets, calves and Colisni sulphas 120 mg administered orally in drinking broilers: 2 days. Anbioc powder for preparaon water or feed. In feed, it is Do not use in laying hens, the of oral soluon. possible to administer the eggs of which are intended for TARGET SPECIES preparaon only individually, i.e. human consumpon. Piglets, calves, domesc fowl. for individual animals. It cannot SHELF LIFE be used for preparaon of INDICATIONS Shelf-life in an intact package: medicated feed mixture for mass 36 months. Prevenon and treatment of administraon. gastrointesnal disorders in Treatment dose: STORAGE piglets, calves and domesc Calves, piglets: 5–8 g of the Store below 25 °C and keep in dry poultry caused by gram-negave preparaon per 100 kg of live place. bacteria (mainly E. coli weight daily (in two dose) PACKAGE and Salmonella spp.). for 3 days. 100 g, 500 g, 3 kg, 5 kg, 10 kg, Domesc fowl: 5–8 g of the 15 kg, 25 kg in closed paper, preparaon per 10 l of drinking plasc or metal covers. water for 3 days. Prevenve dose: Half of the treatment dose. Prepare the medicated drinking water fresh every day.

120 10 Anmicrobial

The acve substances have a broad bactericidal acon against many G+ and G– aerobic bacteria and a broad spectrum of anaerobic bacteria

COTRIMAZIN BIOVETA oral paste for horses Sulfadiazinum, trimethoprimum

COMPOSITION USE DURING PREGNANCY AND SHELF LIFE Acve substances: LACTATION Shelf life of the veterinary 1 g of paste contains: Administraon of this medicinal product as packaged Sulfadiazinum 288.2 mg combinaon of acve substances for sale: 2 years. Shelf life aer Trimethoprimum 58.0 mg during pregnancy, especially first opening of immediate Oral paste. White to light brown in the early stages, can lead to packaging: 6 months. oral paste. congenital defects in foals. Use SPECIAL PRECAUTIONS TARGET SPECIES of the product during pregnancy FOR STORAGE Horses. should be based on a Do not refrigerate or freeze. consideraon of risks versus Store in the original packaging. INDICATIONS FOR USE, benefits by the aending SPECIFYING THE TARGET veterinarian. Sulfonamides pass PACKAGE SIZES SPECIES into maternal milk and may have 1 × 54 g, 5 × 54 g Treatment of bacterial infecons a negave effect on foals suckling in horses (infecons of the from sulfonamide treated mares. digesve tract – diarrhoea, Use of the product during respiratory tract infecons – lactaon should be based on pneumonia, pleurisy, a consideraon of risks versus strangulaon, wound infecons, benefits by the aending sepcaemia, and systemic veterinarian. infecons) caused by microorganisms sensive to the combinaon of acve substances: Rhodococcus equi Staphylococcus spp. Streptococcus spp. Escherichia coli

121 10 Anmicrobial

Water-soluble pulvis containing anbioc, vitamins and unique bovine immunoglobulins

GAMMAVIT BIO powder for oral suspension

COMPOSITION DOSAGE SHELF LIFE 1 bag 25 g contains: Oral administraon. Shelf-life in an intact package: Tetracyclini A dose is 25 g (1 bag) per calf. 1 year. hydrochloridum 750 mg Before administraon, suspend STORAGE Immunoglobulinum the dose in about 200 ml of tea Store below 25 °C and keep in dry bovinum 500 mg or water heated to a temperature place and protect for light. Tocoferoli alfa acetas 30 mg of 25–30 °C to obtain a Renoli acetas 200.000 IU homogeneous suspension PACKAGE Colecalciferolum 15.000 IU without sediment. This 1 × 25 g in mul-layered PE/Al/ homogeneous medicated paper bag, TARGET SPECIES 10 x 25 g. Newborn calves. suspension should be consumed immediately. INDICATIONS Administer the product The product is administered in immediately aer birth, not later breeds with mortality in calves than 24 hours aer birth, and of neonatal diarrhoea caused by repeat the treatment with the Escherichia coli in the ﬁrst days same dose on the second day, of life. Prior to the or on the second and third day. administraon, the situaon in Use immediately aer dissolving! the breed should be well-known, i.e. the presence of disease WITHDRAWAL PERIODS caused by microorganisms Meat – 14 days. sensive to the acve ingredient should be conﬁrmed in the herd.

122 10 Anmicrobial

Injecon anbioc for treatment of infecous diseases of respiratory, gastrointesnal, urogenital tracts, derm and ssue due to bacteria sensive to tylosin

IVATYL TAR 180 000 IU/ml soluon for injecon

COMPOSITION Staph. aureus). Tylosine acvity be administered divided 1 ml of injecon soluon contains against Serpulina hyodysenteriae to 12 hourly intervals. Tylosinum (ut Tylosini tartras) and Streptococcus suis in pigs Adult cale: 30 ml/400 kg 180,000 IU is fluctuang. Also some of body weight. – TARGET SPECIES G anaerobes (B. nodosus, Calves: 3 ml/40 kg of body Cale, pig. F. necrophorum) are sensive to weight. tylosine. Tylosine is acve also Adult pigs: 3 ml/40 kg of body INDICATIONS against Campylobacter coli, weight. Treatment of respiratory, Bacteroides spp., Clostridium Piglets: 0.75 ml/10 kg of body gastrointesnal and urogenital welchii type A and Erysipelothrix weight. tract infecons, skin infecons rhusiopathie. G– pathogens and infecons of so ssue METHOD OF ADMINISTRATION present in the respiratory tract, Intramuscularly. caused by bacteria sensive to such as e.g. Pasteurella tylosine. Tylosine in a form of multocida, Acnobacillus WITHDRAWAL PERIODS soluon for injecon is a pleuropneumonia and Bordetella Meat: cale: 28 days, macrolide anbioc with a spp. are slightly sensive or pigs: 21 days. bacteriostac effect against resistant. G– enterobacteriae Milk: 9 milking. G+ bacteria, some spirochetes, – (E. coli, Salmonella spp., Proteus SHELF LIFE G anaerobic bacteria and mainly spp. and Pseudomonas spp.) are Shelf-life 2 years, aer first against mycoplasma. Tylosine resistant. Reduced sensivity was opening of the immediate demonstrates an obvious in vitro also reported in Serpulina packaging: 28 days. acvity against mycoplasma hyodysenteriae, Streptococcus STORAGE and ureaplasma in pigs (M. suis and Staphylococcus aures in hyopneumoniae, M. hyorhinis, Store at temperature below pigs and Mycoplasma 25 °C. Keep the vial in a box, M. hyosynoviae, Ureaplasma gallisepcum in poultry. spp.), in cale (M. bovis, M. protected against light. Keep mycoides), in dogs (M. canis) DOSAGE the product in a refrigerator aer and most mycoplasma present In ruminants 1 me daily for first opening (2 °C – 8 °C). in poultry. Against pathogens 5–7 days, in pigs 1 me daily PACKAGE causing mass in cale (Str. for up to 5 days. 100 ml and 250 ml in glass vial agalacae and Str.uberis and If necessary, the daily dose may or plasc HDPE boles.

123 10 Anmicrobial

Water-soluble combined anbioc pulvis containing Streptomycinum and Phthalylsulfat- hiazolum intended for calves, dogs and horses

STREPTONAMID peroral powder

COMPOSITION Maximum daily dose and Method of administraon – 1 bag (2.8 g) contains: maximum overall dose perorally, in water or feed. To be Acve substances: Daily dose: administered individually! Streptomycini sulfas 1 000 000 IU Horse – The product is mixed with a small Phthalylsulfathiazolum 1.0 g Streptomycini sulfas amount of feed or water before TARGET SPECIES 6 000 000 IU feeding. In case of total Horses, cale-calves, dogs, Phthalylsulfathiazolum 6 g inappetence, a dose may be piglets. Calf, foal – applied in a bolus or electuary Streptomycini sulfas form. INDICATIONS FOR 2 000 000 IU WITHDRAWAL PERIOD(S) USE,SPECIFYING THE TARGET Phthalylsulfathiazolum 2 g SPECIES Calf meat – 15 days. Do not use in Dog – horses the meat of which is Treatment of infecous diseases Streptomycini sulfas of the digesve tract caused by intended for human 1 000 000 IU – 2 000 000 IU consumpon. bacteria sensive to the acve Phthalylsulfathiazolum 1 g – 2 g substances contained in the SHELF LIFE product, diarrhoea and dysentery Maximum overall dose: Shelf-life of the veterinary in calves, peroral treatment aer Horse – medicinal product as packaged an inial injecon of Streptomycini sulfas for sale: 2 years. streptomycin. 18 000 000 IU Use immediately aer dissolving Phthalylsulfathiazolum 18 g in water or mixing in feed! DOSAGE Calf, foal – Horse: Streptomycini sulfas SPECIAL PRECAUTIONS 2–3 bags twice a day for 3 days 10 000 000 IU FOR STORAGE Calf, foal: Phthalylsulfathiazolum 10 g Keep at a temperature not 1 bag twice a day for 4–5 days Dog – exceeding 25 °C. Dog: Streptomycini sulfas Store in a dry place. 1/2–1 bag twice a day 5 000 000 IU – 10 000 000 IU Protect from light. for 4–5 days Phthalylsulfathiazolum 5 g – 10 g PACKAGE 5 × 2.8 g.

124 11 Anparasics ANTIPARASITICS

Anparasic CANISSHAMPOO BIO KILL 2.5 mg/ml BIOMEC 10 mg/ml BLUE repellent CANIVERM forte CANIVERM mite CANIVERM oral paste EQUIMOXIN 18.92 mg/g EQUISTRONG 400 mg/g EQUIVERM Oral Paste ESB3 Bio 300 mg/g FIPRON 50 mg spot-on soluon for cats FIPRON 67 mg spot-on soluon for dogs S FIPRON 134 mg spot-on soluon for dogs M FIPRON 268 mg spot-on soluon for dogs L FIPRON 402 mg spot-on soluon for dogs XL FIPRON 2.5 mg/ml spray GREEN repellent SULFADIMIDIN BIOVETA 20 g TOP SPOT ON STRONGER 16.25 g TOP SPOT ON STRONGER 650 mg TOP SPOT ON DOG S TOP SPOT ON DOG M 11 TOP SPOT ON DOG L 11 Anparasics

Preparaon containing permethrin with excellent anparasic and repellent eﬀects

Anparasic CANISSHAMPOO

Anparasic shampoo with INSTRUCTION FOR USE SPECIAL STORAGE inseccide formula against fleas, Rub the shampoo gradually into PRECAUTION lice and cks. the dog's wet hair, let work for Keep at temperatures under COMPOSITION a while, rinse and repeat the 25 °C, do not freeze. Permethrinum 0.2%, procedure. Then wipe the dog Keep out of the reach of children. Aqua, Sodium Laureth Sulfate + dry and brush its hair. Protect Only for animals. Cocamide DEA, Cocamide DEA, dog's eyes, ears and muzzle. SHELF LIFE Sodium Chloride, Perfume, In the case of eye, ear or nose 24 months. Piperonyli butoxidum 0.5%, Color, internal contact, irrigate with large quanes of water. PACKAGE Citric acid, 2-bromo-2- 200 ml. nitropropane-1,3 diol. WARNING Parcularly fine and so In the event of a massive aack anparasic shampoo designed of parasites, apply the for hair care of all dog categories formulaon the next day again. and breeds. This effecve At extensive invasion of fleas, anparasic substance infallibly a decontaminaon of the destroys fleas, lice and cks. Its environment will be necessary. composion makes hair easy to comb and keeps it fine and so for a long me.

126 11 Anparasics

Preparaons containing permethrin have excellent anparasic and repellent eﬀects

BIO KILL 2.5 mg/ml cutaneous spray

COMPOSITION DOSAGE SHELF LIFE 1 ml of the product contains Animals - apply the preparaon 24 months. permethrinum 2.5 mg against the direcon of hair and STORAGE Cutaneous spray. White milky feather unl the skin (feather) is Store below 25 °C. emulsion. wet. Long-hair animals should be brushed simultaneously. PACKAGE TARGET SPECIES Posology: 10 mg permethrin (i.e. 100 ml, 500 ml, Dogs, guinea pigs, hamsters, 4 ml of the preparaon) per 1 kg 200 ml. exoc birds. of animal weight, thus: INDICATIONS 20 puffs of a 100-ml package per The product is used against 1 kg of animal body weight, ectoparasites (fleas, lice, cks, 4 puffs of a 500-ml package per mites) in dogs, guinea-pigs, 1 kg of animal body weight. hamsters and exoc birds, against insects (ants, flies, spiders) and Sanitaon of environment – spray for disinfecon of pens and nests. cages, kennels, stalls and stables unl wet with about 25 ml/m2 Sanitaon of environment: (125 puffs of a 100-ml package or BIO KILL 2.5 mg/ml spray is also 25 puffs of a 500 ml package). used to prevent infestaon with If needed, repeat spraying aer the aforemenoned species. 1–2 weeks.

127 11 Anparasics

Highly eﬀecve endectocide for parenteral use in animals

BIOMEC 10 mg/ml injecon soluon

COMPOSITION If treang the animals against STORAGE Ivermecnum 10 mg in 1 ml psoropc mange, repeat the Store at a temperature below Injecon soluon. Clear treatment in 7 days. 25 °C. Protect from light. Keep colourless or yellowish fluid. Pig: out of the reach and sight of TARGET SPECIES Recommended dose is 0.3 mg children. Cale, sheep, pig. ivermecn per kg live weight The product is strongly toxic for (corresponding to 1 ml of the aquac organisms. Any unused INDICATION product per 33 kg live weight). veterinary medicinal product Preparaon is indicated for The product must be or waste materials derived from effecve therapy and to prevent administered subcutaneously, such veterinary medicinal spread of the most common in the neck area, at the products should be disposed parasitary diseases. recommended dose. of in accordance with local DOSAGE WITHDRAWAL PERIOD requirements. Cale: Sheep, pigs: meat: 28 days PACKAGE Recommended dose is 0.2 mg Cale: meat: 49 days, 20 ml, 50 ml, 100 ml, ivermecn per kg live weight milk: Animals producing milk for 250 ml, 500 ml. (corresponding to 1 ml of the human consumpon should not product per 50 kg live weight). be treated with the product Administer the product during lactaon or 28 days before subcutaneously into loose skin expected parturion. in front of or behind the shoulder blade. SHELF LIFE Sheep: 5 years, aer the first opening Recommended dose is 0.2 mg of the immediate ivermecn per kg live weight packaging: 28 days. (corresponding to 0.5 ml of the product per 25 kg live weight). Administer the product subcutaneously into the loose skin between the shoulders.

128 11 Anparasics

A unique combinaon of highly effecve repellent substances. Suitable for daily use. Effecve against bing insects including gnats, mosquitoes, midges and horseflies. Long-term effect.

BLUE repellent applied to horses

COMPOSITION Using safety glasses or other eye P262 Do not get in eyes, on skin, Acve substances: 21.7 g/100 g protecon is recommended or on clothing. P273 Avoid DEET; 10.3 g/100 g ethyl during applicaon. release to the environment. butylacetylaminopropionate (IR Wearing protecve gloves is First aid measures: 3535); 0.5 g/100 g pyrethrins and recommended when the product In case of inhalaon of vapours pyrethroids; 0.1 g/100 g geraniol is applied as a coang. Use provide the vicm with enough in unique combinaon. biocides safely. The product can fresh air. SKIN CONTACT: Wash Excipients: Citronella oil, corrode some plascs and with plenty of water and soap. lavender oil, peppermint oil, synthec fabrics. SKIN IRRITATION OF RASH: Seek eucalypt oil, isopropyl myristate, STORAGE medical advice/treatment. EYE copovidone, benzyl alcohol, Keep in original ghtly sealed CONTACT: Rinse carefully with denatured ethanol containers in a venlated place water for several minutes. Take Instrucons for use: Spray the at a temperature below 30 °C. out the contact lenses if used and product evenly from a distance Do not expose to direct sunlight. if they can be taken out easily. of 20 to 30 cm to the dry and Connue rinsing. If eye irritaon clean hair of the horse! The DANGER persists: Seek medical product may also be applied as a H225 Highly flammable liquid and advice/treatment. INGESTION: coang. Always apply the vapour. H315 Causes skin Rinse mouth with water, drink product to the head of the horse irritaon. H317 May cause an plenty of water. If you feel as a coang using a clean and dry allergic skin reacon. H319 unwell, seek medical advice. cloth or sponge. Avoid applying Causes serious eye irritaon. H411 Toxic to aquac life with PACKAGE the product to the eyes, nostrils 750 ml and mouth of the horse or to long lasng effects. P101 If injured sites. Repeat the medical advice is needed, have applicaon as needed. Mulple product container or label at applicaons per day are hand. P102 Keep out of the reach recommended in periods of high of children. P103 Read label acvity of insects. Always read before use. P210 Keep away from the label and product informaon heat/sparks/open flames/hot before use. surfaces and other sources of ignion. – No smoking.

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Caniverm guarantees suﬃcient eﬃcacy against helminthosis of the gastrointesnal tract in dogs and cats

CANIVERM forte tablets

Anparasic agent against DOSAGE In puppies, the preparaon roundworms and tapeworms. Puppies, small canine and feline is recommended to be COMPOSITION breeds: administered from the week 3 1 tablet – 0.7 g: – 1/2 tablets 0.7 g per 2–5 kg to week 12 of age by a single Fenbendazolum 150 mg of live weight applicaon in an interval Pyranteli embonas 144 mg Medium canine breeds: of 3 weeks and than regularly Praziquantelum 50 mg – 1 tablet 0.7 g per 5–10 kg every 3 months. Tablets. Pale yellow tablets. of live weight SHELF LIFE Large canine breeds and big 24 months. TARGET SPECIES beasts: Dogs, cats. Felines and canines. – 1 tablet 0.7 g per started STORAGE INDICATION 10 kg of live weight Store below 25 °C. Keep in dry place. Protect from light. Diseases caused by ascarids, Route of administraon – oral. tapeworms in dogs, cats, felines Tablets may be administered PACKAGE and canines. (Toxocara canis, separately or wrapped in a piece 2 tablets; 6 tablets; 100 tablets. Toxocara ca, Toxascaris leonina, of food.Do not administer Uncinaria stenocephala, together with dairy food. The Ancylostoma caninum, Trichuris dose should be administered vuplis, Echinoccus granulosus, in a single applicaon. Echinocccus mullocularis, For beasts (Felines and Canidae), Dipylidium caninum, Taenia spp., zoological gardens, circuses, etc. Mulceps mulceps, are recommended to mix crushed Mesocestoides spp.). tablets according to the animal weight in meat balls; these balls are to be placed in the cage before morning feeding in the number corresponding to the number of animals.

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Small tablets – accurate dosing in puppies and kiens

CANIVERM mite tablets

Anparasic agent against POSOLOGY AND METHOD OF In puppies, the preparaon roundworms and tapeworms. ADMINISTRATION is recommended to be COMPOSITION Puppies, small canine and feline administered from the week 3 1 tablet – 0.175 g breeds: to week 12 of age by a single Acve ingredient(s): – 1 tablet 0.175 g per 0.5–2 kg applicaon in an interval Fenbendazolum 37.5 mg of live weight of 3 weeks and than regularly Pyranteli embonas 36.0 mg – 2 tablets 0.175 g per 2–5 kg every 3 months. Praziquantelum 12.5 mg of live weight. SHELF LIFE Tablet, pale yellow tablets. 24 months. Route of administraon – oral. TARGET SPECIES Tablets may be administered STORAGE Dogs, cats. Felines and canines. separately or wrapped in a piece Store below 25 °C, keep in dry INDICATION of food. Do not administer place, protect from light. Diseases caused by ascarids, together with dairy food. PACKAGE tapeworms in dogs, cats, felines The dose should be administered 2 tablets; 6 tablets; 100 tablets and canines. (Toxocara canis, in a single applicaon. Toxocara ca, Toxascaris leonina, For beasts (Felines and Canidae), Uncinaria stenocephala, zoological gardens, circuses, etc. Ancylostoma caninum, Trichuris are recommended to mix crushed vuplis, Echinoccus granulosus, tablets according to the animal Echinocccus mullocularis, weight in meat balls; these balls Dipylidium caninum, Taenia spp., are to be placed in the cage Mulceps mulceps, before morning feeding in Mesocestoides spp.). the number corresponding to the number of animals.

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The anparasic product contains three acve substances, the combinaon of these substances increases eﬃcacy of oral paste with maintaining of maximum safety

CANIVERM oral paste

COMPOSITION DOSAGE SHELF LIFE Acve substances in 1 ml Oral administraon. 18 months, aer ﬁrst opening of paste: The recommended dose is 15 mg the immediate packaging Fenbendazolum 75 mg of fenbendazole, 14.4 mg of 6 months. Pyranteli embonas 72 mg pyrantel embonate and 5 mg STORAGE Praziquantelum 25 mg of praziquantel per kilogram Keep out of the reach of children. Oral paste. Yellow paste. of animal body weight, which This veterinary medicinal product TARGET SPECIES corresponds to 1 ml of paste per does not require any special Dogs and cats. 5 kg of animal body weight. storage condions. Cat: INDICATIONS – 0.5 ml of paste per 0.5–2 kg PACKAGE Diseases caused by helminths in of body weight 1 × 4 ml, 1 × 10 ml dogs and cats (Toxocara canis, – 1 ml of paste per 2.1–5 kg Toxocara ca, Toxascaris leonina, of body weight Uncinaria stenocephala, Dog: Ancylostoma caninum, Trichuris – 0.5 ml of paste per 0.5–2 kg vulpis, Echinococcus granulosus, of body weight Echinococcus mullocularis, – 1 ml of paste per 2.1–5 kg Dipylidium caninum, Taenia spp., of body weight Mulceps mulceps, – then 1 ml of paste per Mesocestoides spp.). each 5 kg of body weight At puppies, the preparaon is recommended to be administered from the week 3 to week 12 of age by a single applicaon in an interval of 3 weeks and then regularly every 3 months.

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The highly eﬀecve product containing moxidecn induces a consistent eﬃcacy against small strongylidae for a two-week period

EQUIMOXIN 18.92 mg/g oral gel for horses Moxidecnum

COMPOSITION Other species: Oxyuris equi weighing 700 kg of bw. 1 gram of gel contains: (adults and larval stages) For accurate dosage it is Acve substance: Habronema muscae (adults) recommended to determine Moxidecnum 18.92 mg Gasterophilus intesnalis (L2, L3) the animal's weight via a tape Translucent, clear to yellow oral Gasterophilus nasalis (L2, L3) measure. The applicator needs gel. Strongyloides westeri (adults) to be adjusted to the calculated TARGET SPECIES Trichostrongylus axei dose by seng the ring on Not food-producing horses. The product induces a consistent the piston marker. INDICATION(S) efficacy against small strongylidae WITHDRAWAL PERIOD Infestaon with parasites for a two-week period. Do not use in horses whose meat hypersensive to moxidecn: Excreon of small strongylidae or milk is intended for human Big strongylidae: Strongylus eggs is suppressed for 90 days. consumpon. vulgaris (adults and arterial The product is effecve against The horse must be declared not stages), Strongylus edentatus (developing) intramucosal stages for food producon. (adults and visceral stages), (L4) of small strongylidae. STORAGE Triodontophorus brevicauda Within 8 weeks aer the Keep out of the reach of children. (adults), Triodontophorus treatment early (hypobioc) L3 Do not freeze. Store in the serratus (adults), stages of small strongylidae are original package to protect the Triodontophorus tenuicollis eliminated. product from light. Do not use (adults) DOSAGE aer its expiry date stated on the Small strongylidae (adults and A single-dose oral administraon. label and the carton. intraluminal larval stages): The recommended dose is 0.4 mg Use during pregnancy, lactaon Cyathostomum spp., Cylicocyclus of moxidecn/kg per body The product can be used during spp., Cylicostephanus spp., weight, which equals to 1.056 g pregnancy or lactaon. Cylicodontophorus spp., of product/50 kg bw. SHELF LIFE Gyalocephalus spp. One part of a piston scale on the 24 months, aer first opening the Roundworms: Parascaris applicator equals to the immediate packaging: 6 months equorum (adults and larval recommended dose of 50 kg per stages) PACKAGE bw of a horse. The content of one 1 × 14.8 g, 10 × 14.8 g applicator is intended for a horse

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Safe paste for the stallion, pregnant and lactang mare and suckling foals

EQUISTRONG 400 mg/g oral paste for horses

COMPOSITION 100 kg live weight. One scale or, if this is not possible, 1 g of the paste contains pyranteli division shows the dose postpone their transfer to June. embonas – 400 mg per 100 kg live weight. SUPPRESSION AND Oral light yellow paste. Dosing regimen: TREATMENT OF For horses. – Foals (1–8 months age): ANOPLOCEPHALOSIS INDICATIONS 1 dose (4.75 g of the paste) per Recommended dose is 38 mg Suppression and treatment of 100 kg live weight every 4 weeks. of pyrantel embonate per kg live infecons caused by adult small – Horses (more than 8 months weight, or 9.5 g of the paste per and large strongylides, pinworms, age): 1 dose (4.75 g of the paste) 100 kg live weight. Two scale roundworms and tapeworms per 100 kg live weight every divisions show the dose per in horses. 6–8 weeks. Every 4–6 weeks 100 kg live weight. Pyrantel embonate is a broad- during the grazing season. When Repeat applicaon in 6 weeks spectrum anthelminc transferring the horse to grazing if necessary. which is eﬃcacious against: following winter stabling, always administer 1 dose of the paste SHELF LIFE large strongyles: Strongylus 24 months. vulgaris, S. edentatus, S. equinus 3–4 days before pung the small strongyles: Trichonema spp. animal out to pasture. STORAGE (Cyathostomes), Triodontophorus – Nursing mares: It has been This veterinary medicinal product spp. shown that strongyle infestaon does not require any special pinworms Oxyuris equi in sucklings during the grazing storage condions. Store in a dry roundworms: Parascaris equorum season can be reduced by using place. tapeworms: Anoplocephala “clean” pastures (transfer of the PACKAGE perfoliata horses or not grazing down by 1 × 28.5 g (1 applicator) horses previous year), by 10 × 28.5 g (10 applicators) DOSAGE administering the product to One applicator contains 11.4 g nursing mares 3–4 days before of pyrantel embonate in 28.5 g transfer and aerwards of peroral paste. repeatedly every 2–4 weeks ll Recommended dose is 19 mg the end of autumn. The ideal of pyrantel embonate per kg live paern is to put the mares with weight, or 4.75 g of the paste per the foals out to “clean” pastures

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Wide - spectrum paste for the eﬀecve rotaonal deworming programme

EQUIVERM oral paste for horses

COMPOSITION The applicator should be adjusted SHELF LIFE 1 ml of the paste contains to the calculated dose by seng Shelf-life of the veterinary ivermecnum 20 mg the ring on a respecve piston medicinal product as packaged praziquantelum 100 mg posion. for sale: 2 years, aer ﬁrst Oral paste. Fine olive green paste. Hold the piston of applicator, turn opening the immediate For horses the grooved dosing ring on the packaging: 6 months. INDICATION piston so that the boom edge of STORAGE Treatment of parasic diseases the ring is aligned with the mark Store below 25 °C. caused by the most common of the desired weight. Make sure Store in a ghtly closed species of helminths. Treatment that the horse has no feed applicator. of bots. residues in its mouth. Remove Aer use, replace the cap again. the cap from the applicator, DOSAGE insert it into the horse's mouth PACKAGE Oral administraon. and apply the paste to the root 1 × 7 ml, 10 × 7 ml. The recommended dose is 200 µg of the tongue. Aer applicaon of ivermecn and 1 mg of li the horse's head immediately praziquantel per kilogram of for a few seconds and make sure animal body weight, which that the horse has swallowed corresponds to a single dose the dose. of 1 ml of the paste per 100 kg Anparasic programme of animal body weight. In order to achieve an adequate The body weight of a horse and level of prevenon against dosage should be determined parasic infestaon, it is precisely before starng necessary to provide veterinary treatment. The contents of one consultancy on appropriate applicator will be suﬃcient for dosing and zoohygienic treatment of a horse weighing up condions. to 700 kg. The applicator is calibrated by 100 kg of weight.

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Sulfaclozin contained in the powder interferes with the development cycle of coccidia and prevents their mulplicaon

ESB3 Bio 300 mg/g powder for oral soluon Sulfaclozinum

COMPOSITION for two days and connue the WITHDRAWAL PERIOD 1 gram of product contains therapy with the same dose Domesc fowl: meat: 16 days. sulfaclozinum natricum for 3 days. Turkey: meat: 28 days. monohydricum 300 mg The product is applied to drinking Rabbit: meat: 15 days. Powder for oral soluon. water, a fresh soluon is Do not use in layers producing Off-white to yellowish crystalline prepared daily. Treated animals eggs for human consumpon. powder. should not have access to SHELF LIFE INDICATION another source of drinking water. 36 months, aer first opening the Coccidiosis due to infecon with If water intake is higher than the immediate packaging: 3 weeks, E. tenella, E. necatrix, calculated volume, non- aer reconstuon in drinking E. acervulina, E. brune, medicated drinking water should water: 24 hours. be administered for the rest of E. maxima, E. mis-miva, STORAGE E. praecox, E. adenoides, a day. There is no need to change the feeding regime. Keep out of the reach E. meleagrimis. of children. Store below Bacterial disease in poultry and The 3-day treatment can be replaced by the product 25 °C. Protect from light. rabbits due to infecon with Keep in a dry room. Salmonella gallinarum, applicaon on days 1, 3 and 5 Pasteurella multocida. Moreover, (or even 7 and 9), or for example PACKAGE Coryza contagiosa, necroc on days 1, 2, 5, or even 6 and 9. 5 × 10 g, 250 g, 1 kg, 5 kg. enteris in poultry. In the flocks where coccidiosis occurs only from me to me, TARGET SPECIES a prevenve 2 or 3-day Broilers and breeding chickens, administraon is recommended turkeys, rabbits. in weeks 3 and 5 of age. DOSAGE The laying hens, whose eggs are Domesc fowl and turkeys: not intended for human 1 g of the product per 1 litre consumpon, are treated at of water for 3 days. the onset of lay. Rabbits: 2 g of the product per 1 litre of drinking water for 3 days, then skip the medicaon

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Fipronil as an acaricide acts on salivary glands of cks, thereby disabling sucon on an animal

FIPRON 50 mg spot-on soluon for cats

COMPOSITION DOSAGE STORAGE 1 tube (0.5 ml) contains For lack of data the minimum This veterinary medicinal product fipronil 50 mg me between two applicaons does not require any special Spot-on soluon. is 4 weeks. temperature storage condions. Clear, yellow to yellow-green Method of administraon: Store in the original container soluon. spot-on use. in order to protect from light. TARGET SPECIES Dosage: Store in a dry place. Cats. Apply 1 tube of 0.5 ml of the skin PACKAGE between the shoulder blades. 1, 3 or 25 single-dose tubes. INDICATION One dose ensures protecon Treatment and prevenon of flea against flea infestaon for up infestaon (Ctenocephalides felis) to 5 weeks. The product is and related flea allergy dermas effecve against cks (FAD) in cats. Treatment and for 3 to 4 weeks. prevenon of infestaon by cks (Ixodes spp.) and lice (Felicola SHELF LIFE subrostratus) in cats. 24 months, use immediately aer opening the bag.

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It can be applied to puppies, kiens, pregnant and lactang female dogs or cats

FIPRON 67 mg spot-on soluon for dogs S

COMPOSITION This ensures a minimum STORAGE One tube (0.67 ml) contains recommended dose of fipronil This veterinary medicinal product fipronil 67 mg of 6.7 mg/kg bw. does not require any special Spot-on soluon. Monthly treatment is temperature storage condions. Clear, yellow to yellow-green recommended in case of a high Store in the original container soluon. risk of repeated aacks by fleas, in order to protect from light. TARGET SPECIES if the dog is allergic to flea bites, Store in a dry place. Dogs. in case of necessary control of PACKAGE ck infestaon, or at frequent 1, 3 or 25 single-dose tubes. INDICATION bathing of the dog using Treatment and prevenon of flea hypoallergenic or moisturizing infestaon (Ctenocephalides spp.) shampoos. In areas where there and related flea allergy dermas is no serious infestaon by fleas (FAD) in dogs. Treatment and and cks, FIPRON spot-on for prevenon of infestaon by cks dogs can be applied every two to (Rhipicephalus spp., three months. Dermatocentor spp., Ixodes spp.) FIPRON spot-on for dogs is and lice (Trichodectes canis) in effecve against flea infestaon dogs. for approximately two months DOSAGE and against cks for up to For lack of data the minimum 1 month, depending on the me between two applicaons strength of environmental is 4 weeks. contaminaon. Fleas are killed Method of administraon: within 24 hours aer infestaon. spot-on use. Dosage depends on the weight SHELF LIFE of animal. 24 months, use immediately aer Dogs weighing 2–10 kg: opening the bag. the contents of one tube of 0.67 ml (S).

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It kills ﬂeas in 18 hours aer applicaon and eliminates cks in 24–48 hours aer applicaon

FIPRON 134 mg spot-on soluon for dogs M

COMPOSITION This ensures a minimum STORAGE One tube (1,34 ml) contains recommended dose of fipronil This veterinary medicinal product fipronil 134 mg of 6.7 mg/kg bw. does not require any special Spot-on soluon. Monthly treatment is temperature storage condions. Clear, yellow to yellow-green recommended in case of a high Store in the original container soluon. risk of repeated aacks by fleas, in order to protect from light. TARGET SPECIES if the dog is allergic to flea bites, Store in a dry place. Dogs. in case of necessary control of PACKAGE ck infestaon, or at frequent 1, 3 or 25 single-dose tubes. INDICATION bathing of the dog using Treatment and prevenon of flea hypoallergenic or moisturizing infestaon (Ctenocephalides spp.) shampoos. In areas where there and related flea allergy dermas is no serious infestaon by fleas (FAD) in dogs. Treatment and and cks, FIPRON spot-on for prevenon of infestaon by cks dogs can be applied every two to (Rhipicephalus spp., three months. Dermatocentor spp., Ixodes spp.) FIPRON spot-on for dogs is and lice (Trichodectes canis) in effecve against flea infestaon dogs. for approximately two months DOSAGE and against cks for up to For lack of data the minimum 1 month, depending on me between two applicaons the strength of environmental is 4 weeks. contaminaon. Fleas are killed Method of administraon: within 24 hours aer infestaon. spot-on use. Dosage depends on the weight SHELF LIFE of animal. 24 months, use immediately aer Dogs weighing above 10 kg and opening the bag. to 20 kg: the contents of one tube of 1.34 ml (M)

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Fipronil kills a ﬂea or ck upon a mere contact, an insect does not need to suck blood for the eﬀect to occur

FIPRON 268 mg spot-on soluon for dogs L

COMPOSITION This ensures a minimum STORAGE One tube (2.68 ml) contains recommended dose of fipronil This veterinary medicinal product fipronil 268 mg of 6.7 mg/kg bw. does not require any special Spot-on soluon. Monthly treatment is temperature storage condions. Clear, yellow to yellow-green recommended in case of a high Store in the original container soluon. risk of repeated aacks by fleas, in order to protect from light. TARGET SPECIES if the dog is allergic to flea bites, Store in a dry place. Dogs. in case of necessary control of PACKAGE ck infestaon, or at frequent 1, 3 or 25 single-dose tubes. INDICATION bathing of the dog using Treatment and prevenon of flea hypoallergenic or moisturizing infestaon (Ctenocephalides spp.) shampoos. In areas where there and related flea allergy dermas is no serious infestaon by fleas (FAD) in dogs. Treatment and and cks, FIPRON spot-on for prevenon of infestaon by cks dogs can be applied every two (Rhipicephalus spp., to three months. Dermatocentor spp., Ixodes spp.) FIPRON spot-on for dogs is and lice (Trichodectes canis) in effecve against flea infestaon dogs. for approximately two months DOSAGE and against cks for up to For lack of data the minimum 1 month, depending on the me between two applicaons strength of environmental is 4 weeks. contaminaon. Fleas are killed Method of administraon: within 24 hours aer infestaon. spot-on use. Dosage depends on the weight SHELF LIFE of animal. 24 months, use immediately aer Dogs weighing above 20 and to opening the bag. 40 kg: the contents of one tube of 2.68 ml (L)

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A broad spectrum of eﬀects in comparison with other preparaons

FIPRON 402 mg spot-on soluon for dogs XL

COMPOSITION One tube of 4.02 ml and one STORAGE One tube (4.02 ml) contains pipee of the suitable smaller This veterinary medicinal product fipronil 402 mg size for dogs weighing above does not require any special Spot-on soluon. 60 kg bw. temperature storage condions. Clear, yellow to yellow-green Monthly treatment is Store in the original container soluon. recommended in case of a high in order to protect from light. TARGET SPECIES risk of repeated aacks by fleas, Store in a dry place. Dogs. if the dog is allergic to flea bites, PACKAGE in case of necessary control of 1, 3 or 25 single-dose tubes. INDICATION ck infestaon, or at frequent Treatment and prevenon of flea bathing of the dog using infestaon (Ctenocephalides spp.) hypoallergenic or moisturizing and related flea allergy dermas shampoos. In areas where there (FAD) in dogs. Treatment and is no serious infestaon by fleas prevenon of infestaon by cks and cks, FIPRON spot-on for (Rhipicephalus spp., dogs can be applied every two Dermatocentor spp., Ixodes spp.) to three months. and lice (Trichodectes canis) in FIPRON spot-on for dogs is dogs. effecve against flea infestaon DOSAGE for approximately two months For lack of data the minimum and against cks for up to me between two applicaons 1 month, depending on the is 4 weeks. strength of environmental Method of administraon: contaminaon. Fleas are killed spot-on use. within 24 hours aer infestaon. Dosage depends on the weight of animal. SHELF LIFE Dogs weighing above 40 kg: 24 months, use immediately aer the contents of one tube opening the bag. of 4.02 ml (XL)

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The product is badly soluble in water, which ensures its resistance against rain

FIPRON 2.5 mg/ml cutaneous spray, soluon

COMPOSITION This dose may be increased up to SHELF LIFE 1 ml of the spray contains a double in dependence on the 24 months. fipronilum 2.5 mg animal's hair length, i.e. to 15 mg STORAGE Cutaneous spray, soluon of fipronil per kg of the animal's Store below 25 °C. TARGET SPECIES body weight, in pracce up to Protect from frost. Dogs, cats. 12 squeezes of the applicaon pump per kg of the animal's body PACKAGE INDICATION weight when using the 100 ml 1 × 100 ml, 1 × 250 ml. Treatment and prevenon of flea packaging or 4 squeezes per kg aack and associated allergies of the animal's body weight when to flea bite. Treatment and using the 250 ml packaging. prevenon of louse and ck Spray the whole animal's body aacks. from a 10–20 cm distance against DOSAGE the direcon of the hair/fur. Generally, the dose is 7.5 mg of Usually, a brush or comb is used Fipronil per kg of the animal's simultaneously. All hair/fur body weight, i.e. in pracce 3 ml should be moisturized uniformly of the product or 6 squeezes of with the product so the the applicaon pump per kg of preparaon can penetrate as far the animal's body weight when as the skin. For the treatment of using the 100 ml packaging or the head and skin around the 2 squeezes of the cap per kg eyes, spray the product onto a of the animal's body weight when wet glove and rub it carefully into using the 250 ml packaging. the hair/fur. Avoid spraying into the eyes. Since no safety studies are available, do not apply the product more frequently than once in 4 weeks.

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A unique combinaon of highly effecve natural oils (Gerosil 9) with a high repellent effect. Suitable for daily use. Effecve against bing insects including gnats, mosquitoes, midges and horseflies. Soluon of vegetable origin. Free of neurotoxic poisons. Long-term effect. GREEN repellent applied to horses

COMPOSITION Mulple applicaons per day are P103 Read label before use. Acve substances: recommended in periods of high P210 Keep away from Geraniol 2.16 g/100 g, acvity of insects. Always read heat/sparks/open flames/hot citriodiol 2.96 g/100 g, the label and product informaon surfaces and other sources of geranium oil 0.98 g/100 g, before use. Using safety glasses ignion. No smoking. P260 Do citronella oil 2.47 g/100 g in or other eye protecon is not breathe vapours. P262 Do not unique combinaon (Gerosil 9). recommended during get in eyes, on skin. Excipients, hazardous applicaon. Wearing protecve components: Denatured ethanol, gloves is recommended when the PACKAGE citronellal, lavender oil, product is applied as a coang. 750 ml peppermint oil, eucalyptus oil. Use biocides safely. Instrucons for use: Spray the STORAGE product evenly from a distance of Keep in original ghtly sealed 20 to 30 cm to the dry and clean containers in a venlated place at hair of the horse! The product a temperature below 30 °C. Do may also be applied as a coang. not expose to direct sunlight. Always apply the product to the DANGER head of the horse as a coang using a clean and dry cloth or H225 Highly flammable liquid and sponge. Avoid applying the vapour. H317 May cause an product to the eyes, nostrils and allergic skin reacon. H319 mouth of the horse or to injured Causes serious eye irritaon. sites. Repeat the applicaon as H412 Harmful to aquac life with needed. long lasng effects. P101 If medical advice is needed, have product container or label at hand. P102 Keep out of the reach of children.

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Besides eﬃcacy against Eimeria spp. has excellent bacteriostac eﬀect against G– and G+ bacteria inducing gastrointesnal and respiratory infecons

SULFADIMIDIN BIOVETA 20 g powder for preparaon of peroral soluon Sulfadimidinum natricum

COMPOSITION DOSAGE SHELF LIFE 1 bag (containing 20 g of the 1 bag is dissolved in 10 liters of 36 months, aer diluon in preparaon corresponding to one potable water and administered potable water according to dose) contains sulfadimidinum instead of beverages for 3 days. direcons: 24 hours. natricum 20 g This 3-day treatment is repeated, STORAGE INDICATION if necessary, but only aer Keep out of the reach and sight Coccidiosis, parcularly in poultry expiraon of the 3-day break of children. Do not store above and rabbits. Treatment of without any treatment. 25 °C. Store in a dry place. infecous diseases caused by Prevenve administraon to Protect from light. Keep out of the nuclei sensive to rabbits is suitable at the age the reach and sight of children. sulfadimidine. Connuaon of of 5–10 weeks, preferably aer 2–3 day break of potable water PACKAGE treatment started by applicaon 1 sachet a 20 grams, of the injecon sulfadimidine. and lush fodder. Method of administraon – 5 × 1 sachets a 20 grams. TARGETS SPECIES perorally in the beverage. Poultry, rabbits, calves, pigs, lambs. WITHDRAWAL PERIOD Meat – 15 days. Do not use in the laying hens whose eggs are speciﬁed for human consumpon.

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The product is waterproof and sweat – resistant

TOP SPOT ON STRONGER 16.25 g soluon for applicaon on skin – spot-on for horses

COMPOSITION DOSAGE SHELF LIFE 1 vial (25 ml corresponding to Horses – the contents 24 months. one dose) contains permethrin of 1 package (25 ml) for horses STORAGE 16.25 g with weight approximately Store at a temperate below 25 °C. Soluon for applicaon on skin – 500 kg. The preparaon is applied Protect from light. spot-on. on several sites on skin in Protect from cold and freeze. Light yellow, clear soluon. the area of the withers and shoulders in a quanty PACKAGE TARGET SPECIES 1 × 25 ml, 6 × 25 ml. Horses. of 2–3 ml in one site. Fur is spread before applicaon INDICATION and the soluon is applied with Therapeuc and prevenve usage an applicator directly on skin. in horses against ectoparasites Do not rub in. It is necessary to and flying insects (cks, ensure applicaon of the mosquitoes, horse-flies, gad-flies preparaon on such a place, from and black-flies). which the animal cannot lick it and prevent mutual licking among animals. If the animals get wet aer treatment or they are shampooed, it is necessary to repeat the therapy. The interval between individual treatments should be at least 7 days.

145 11 Anparasics

Permethrin with very low toxicity to warm-blooded animals

TOP SPOT ON STRONGER 650 mg soluon for applicaon on skin – spot-on for dogs

COMPOSITION above 30 kg – content SHELF LIFE 1 applicator (1 ml) of the soluon of 3 applicators (3 × 1 ml) is 24 months. contains permethrin 650 mg applied on skin in the area STORAGE Soluon for applicaon on skin – between the shoulder blades, Store at a temperature below spot-on. middle of the back and in the 25 °C. Protect from light. Light yellow, clear soluon. root of the tail in large dog Protect from cold and freeze. TARGET SPECIES breeds – (Dog L or 3 applicators from mass packaging). PACKAGE Dogs. 1 × 1 ml (S), INDICATION METHOD OF ADMINISTRATION 2 × 1 ml (M), Therapeuc and prevenve usage Only for administraon by 3 × 1 ml (L), in dogs against ectoparasites – insllaon on skin. 25 × 1 ml, 50 × 1 ml, ﬂeas, cks. Fur is spread before applicaon 100 × 1 ml. and the soluon is applied with DOSAGE an applicator directly on skin. Dogs Do not rub in. It is necessary to up to 15 kg – content ensure applicaon of the of 1 applicator (1 ml) is applied preparaon on such a place, from on skin in the area between the which the animal cannot lick it shoulder blades in small dog and prevent mutual licking breeds – (Dog S or 1 applicator among animals. If dogs get wet from mass packaging). aer treatment or they are from 15 to 30 kg – content shampooed, it is necessary to of 2 applicators (2 × 1 ml) is repeat the therapy. The interval applied on skin in the area between individual treatments between the shoulder blades and should be at least 7 days. in the root of the tail in moderate dog breeds – (Dog M or 2 applicators from mass packaging).

146 11 Anparasics

One dose of product = reliable protecon against ﬂeas for 3 months, against cks for 4 weeks

TOP SPOT ON DOG S soluon for applicaon on skin – spot-on for dogs

COMPOSITION DOSAGE SHELF LIFE 1 applicator (1 ml) Only for administraon by 24 months. of the soluon contains insllaon on skin. STORAGE permethrin 650 mg Dogs weighing less than 15 kgs – Protect from light. Soluon for applicaon on skin – content of one applicator (1 ml) is Protect from cold and freeze. spot-on. applied on skin in the area Light yellow, clear soluon. between the shoulder blades in PACKAGE 1, 3 or 10 single-dose tubes. TARGET SPECIES small dog breeds. Dogs (less than 15 kgs). METHOD OF ADMINISTRATION INDICATIONS Hold the tube with the neck Therapeuc and prevenve usage upwards and knock the neck in dogs against ectoparasites – repeatedly with your finger. Break fleas, cks off the p carefully by twisng (Ctenocephalides spp., moon. Part the hair of the Ixodes spp.) animal in the withers in front Recommended dose of the of the shoulder blades unl the TOP SPOT ON DOG S provides skin is visible. Place the applicator protecon against cks p on the skin and press the tube infestaon for 4 weeks and repeatedly to empty the enre against fleas infestaon contents of the tube directly for 3 months. on the skin. CONTRAINDICATION Product should not be used in cats, as this product is toxic for cats. Top Spot on Dog S should not be used in puppies less than 3 weeks old and dogs weighing less than 2 kgs. Follow the recommended dosage

147 11 Anparasics

Depo eﬀect, good local and systemic tolerance

TOP SPOT ON DOG M soluon for applicaon on skin – spot-on for dogs

COMPOSITION DOSAGE SHELF LIFE 1 applicator (2 ml) of the soluon Only for administraon by 24 months. contains permethrin 1300 mg insllaon on skin. STORAGE Soluon for applicaon on skin – Dogs weighing 15–30 kgs – Protect from light. spot-on. content of one applicator (2 ml) Protect from cold and freeze. Light yellow, clear soluon. is applied on skin in the area between the shoulder blades and PACKAGE TARGET SPECIES 1, 3 or 10 single-dose tubes. Dogs (15–30 kgs). in the root of the tail in medium dog breeds. INDICATIONS Therapeuc and prevenve usage METHOD OF ADMINISTRATION in dogs against ectoparasites – Hold the tube with the neck fleas, cks (Ctenocephalides spp., upwards and knock the neck Ixodes spp.) repeatedly with your finger. Break Recommended dose of the off the p carefully by twisng TOP SPOT ON DOG M provides moon. Part the hair of the protecon against cks animal in the withers in front of infestaon for 4 weeks and the shoulder blades unl the skin against fleas infestaon is visible. Place the applicator p for 3 months. on the skin and press the tube repeatedly to empty the enre CONTRAINDICATION contents of the tube directly on Product should not be used in the skin. cats, as this product is toxic for cats. Top Spot on Dog M should not be used in puppies less than 3 weeks old. Follow the recommended dosage.

148 11 Anparasics

Using preparaons containing permethrin can signiﬁcantly reduce the incidence of ck-borne diseases in humans and animals

TOP SPOT ON DOG L soluon for applicaon on skin – spot-on for dogs

COMPOSITION DOSAGE SHELF LIFE 1 applicator (3 ml) of the soluon Only for administraon by 24 months. contains permethrin 1950 mg insllaon on skin. STORAGE Soluon for applicaon on skin – Dogs weighing above 30 kgs – Protect from light. spot-on. content of one applicator (3 ml) Protect from cold and freeze. Light yellow, clear soluon. is applied on skin in the area between the shoulder blades, PACKAGE TARGET SPECIES 1, 3 or 10 single-dose tubes. Dogs (above 30 kgs). middle of the back and in the root of the tail in large dog INDICATIONS breeds in large dog breeds. Therapeuc and prevenve usage in dogs against ectoparasites – METHOD OF ADMINISTRATION fleas, cks Hold the tube with the neck (Ctenocephalides spp., Ixodes upwards and knock the neck spp.) repeatedly with your finger. Break Recommended dose of the off the p carefully by twisng TOP SPOT ON DOG L provides moon. Part the hair of the protecon against cks animal in the withers in front of infestaon for 4 weeks and the shoulder blades unl the skin against fleas infestaon is visible. Place the applicator p for 3 months. on the skin and press the tube repeatedly to empty the enre CONTRAINDICATION contents of the tube directly Product should not be used in on the skin. cats, as this product is toxic for cats. Top Spot on Dog L should not be used in puppies less than 3 weeks old. Follow the recommended dosage

149 150 ANTIANAEMICS

FERRIBION 100 mg/ml GAFERVIT 12 GAFERVIT mite 12 Ananaemics

Injecon ananaemic product with trivalent iron in the dextraferranum form

FERRIBION 100 mg/ml injecon soluon

COMPOSITION ROUTE OF ADMINISTRATION 1 ml of injecon soluon Intramuscularly. contains: WITHDRAWAL PERIOD Dextraferranum 100,000 mg None. TARGET SPECIES SHELF LIFE Cale, horses, sheep, goats, Shelf-life 2 years, aer ﬁrst piglets, dogs, minks, foxes. opening of the immediate INDICATIONS packaging: 28 days. Anemia, hypoglobulinemia, STORAGE cachexy, delayed development, Store in a refrigerator weaning-related diseases (2 °C – 8 °C). (diarrhea, inappetence, etc.), piglet metabolism disorders. PACKAGE 50 ml, 100 ml, 500 ml in glass vial DOSAGE or plasc HDPE bole. Prophylaccally Therapeucally Adult cale, horse 4 – 8 ml 8 – 12 ml Calf, sheep, goat 2 – 4 ml 4 – 6 ml Piglet (2 – 3 days old) 1 – 2 ml 2 – 2.5 ml Lamb 1.5 – 2.5 ml 2 – 4 ml Dog 1 – 2 ml Prophylacc doses Mink (8 – 12 weeks old) 0.5 ml should be repeated Mink (3 months and above) 1 ml 2–3 mes Fox (6 – 12 weeks old) 1 ml at the intervals Fox (3 months and above) 2 ml of 1–2 weeks

The injecon is applied into the gluteal musculature on a medial thigh surface and into the neck musculature in piglets and other animals, respecvely.

152 12 Ananaemics

Injecon ananemic, immunoprevenve and vitamin of group B product with the unique content of pure porcine immunoglobulines

GAFERVIT injecon soluon

COMPOSITION TARGET SPECIES ROUTE OF ADMINISTRATION 100 ml of injecon soluon Piglets. Intramuscularly. contains: INDICATIONS WITHDRAWAL PERIOD Immunoglobulinum suillum Anemia, hypoglobulinemia, None. navum 5000,000 mg cachexy, delayed development, SHELF LIFE Dextraferranum 700,000 mg weaning-related diseases Thiamini Shelf-life 2 years, aer ﬁrst (diarrhea, inappetence, etc.), opening of the immediate hydrochloridum 3,000 mg piglet metabolism disorders. Riboﬂavinum 1,140 mg packaging: 28 days. Pyridoxini DOSAGE STORAGE hydrochloridum 0,280 mg Piglets Store in a refrigerator Niconamidum 42,840 mg up to 10 days of age 3 ml (2 °C – 8 °C). Piglets from 10 to 20 days Calcii pantothenas 1,600 mg PACKAGE Cupri chloridum 2,707 mg of age 5 ml Piglets over 20 days of age 10 ml 10 ml, 20 ml, 50 ml, 100 ml, Cobaltosi chloridum 250 ml, 500 ml and 1.000 ml in anhydricum 0,266 mg glass vial or plasc HDPE bole. Thiomersalum Natrii chloridi soluo 9 g/l parenteralis

153 12 Ananaemics

Injecon ananemic, immunoprevenve and vitamin of group B product with the unique content of porcine serum

GAFERVIT mite injecon soluon

COMPOSITION DOSAGE STORAGE 1 ml of injecon soluon Piglets Store in a refrigerator contains: up to 10 days of age 5 ml (2 °C – 8 °C). Serum suillum navum 0.8 ml Piglets PACKAGE Dextraferranum 7 mg from 10 to 20 days of age 10 ml 10 ml, 20 ml, 50 ml, 100 ml, Thiamini hydrochloridum 0.03 mg Piglets over 20 days of age 20 ml 250 ml, 500 ml and 1.000ml Riboﬂavinum 0.0114 mg ROUTE OF ADMINISTRATION in glass vial or plasc HDPE Pyridoxini Intramuscularly. bole. hydrochloridum 0.0028 mg Niconamidum 0.4284 mg WITHDRAWAL PERIOD Calcii pantothenas 0.016 mg None. Cupri chloridum 0.02707 mg SHELF LIFE Cobaltosi chloridum Shelf-life 2 years, aer ﬁrst anhydricum 0.00266 mg opening of the immediate TARGET SPECIES packaging: 28 days. Piglets. INDICATIONS Anemia, hypoglobulinemia, cachexy, delayed development, weaning-related diseases (diarrhea, inappetence, etc.), piglet metabolism disorders.

154 ANAESTHETICS

NALGOSED 10 mg/ml NARKAMON 100 mg/ml NARKAMON 50 mg/ml ROMETAR 20 mg/ml Sedan 35 mg/ml XYLASED 100 13 XYLASED 500 13 Anaesthecs

Butorphanol is a central nervous system acng analgesic with both opiate agonist and antagonist acvity

NALGOSED 10 mg/ml soluon for injecon Butorphanolum COMPOSITION alone: Administer a dose of anaesthesia is used 1 ml of the soluon for injecon 0.2-0.3 mg/kg bw, equivalent to (acepromazine/ketamine or contains butorphanol 10 mg (as 0.02-0.03 ml of the product/kg xylazine/ketamine), administer butorphanol tartrate 14.58 mg) bw, i.e. 0.2-0.3 ml/10 kg bw, by butorphanol 5 minutes before INDICATION IV, IM or SC injecon. administering the anaesthec. The product is indicated for As a sedave: Butorphanol in As a postoperave analgesic: the management of analgesia combinaon with medetomidine i) Intramuscular, subcutaneous and sedaon in horses; for the As a preanaesthec: Butorphanol administraon management of analgesia, alone: Administer a dose of ii) Intravenous administraon sedaon and preanaesthesia 0.1-0.2 mg/kg bw, equivalent to As a sedave: Butorphanol in in dogs and cats. 0.01-0.02 ml of the product/kg combinaon with medetomidine bw, by IV, IM or SC injecon. As a part of the anaesthesia TARGET SPECIES As a sedave and preanaesthec protocol: Butorphanol in Dogs, cats, horses. – premedicaon of barbiturate combinaon with medetomidine DOSAGE anaesthesia: Butorphanol in and ketamine HORSE: Only for intravenous (IV) combinaon with medetomidine i) Intravenous administraon administraon, DOG, CAT: As a part of the anaesthesia ii) Intramuscular administraon Intravenous (IV), subcutaneous protocol: Butorphanol in SHELF LIFE (SC) or intramuscular (IM) combinaon with medetomidine Shelf life of the veterinary administraon and ketamine medicinal product as packaged HORSE CAT for sale: 2 years. As an analgesic: Butorphanol As a preoperave analgesic: Shelf life aer ﬁrst opening the alone: Administer a dose of Butorphanol alone: Administer a immediate packaging: 28 days. 0.1 mg/kg bw, equivalent to dose of 0.4 mg/kg bw, equivalent 0.01 ml of the product/kg bw, i.e. to 0.04 ml of the product/kg bw, SPECIAL STORAGE 1 ml/100 kg bw, by IV injecon. i.e. 0.2 ml/5 kg bw, by IM or SC PRECAUTIONS As a sedave: Butorphanol in injecon. When intravenous This veterinary medicinal product combinaon with detomidine inducon of anaesthesia is used, does not require any special or butorphanol in combinaon administer butorphanol storage condions. with romiﬁdine 15–30 minutes before Protect from light. DOG administering the anaesthec. PACKAGE As an analgesic: Butorphanol When intramuscular inducon of 10 ml.

156 13 Anaesthecs

Ketamine is used with other agents for sedaon, analgesia and total dissociave anesthesia

NARKAMON 100 mg/ml soluon for injecon Ketamine

COMPOSITION Dog SHELF LIFE 1 ml of clear, colourless soluon Monoanaesthesia 0.1–0.2 ml of Shelf-life 24 months, aer first for injecon contains the product/kg of live weight (i.e. opening the immediate ketaminum 100 mg. 10–20 mg of ketamine/kg of live packaging 28 days. INDICATION weight) intramuscularly SPECIAL STORAGE Short term general anaesthesia Combinaon opons: atropin PRECAUTIONS in dogs, cats, horses and donkeys 0.05 mg/kg of live weight i.v., Keep out of the reach of children. for diagnosc and therapeuc i.m., s.c. together with Keep the vial in a box, protected procedures. acepromazine in a dose against light. Protect from frost. of 0.1 mg/kg of live weight, aer TARGET SPECIES iniaon of their effect PACKAGE Dogs, cats, horses and donkeys. NARKAMON 100 mg/ml soluon 10ml, 50 ml. DOSAGE for injecon in a dose Method of administraon: of 0.2 ml/10 kg of live weight. intramuscular or intravenous. (i.e. 2 mg of ketamine/kg of live The dosage should be adjusted weight) intravenously individually to individual paents. Cat Horse Monoanaesthesia 0.2–0.4 ml The usual dose is 2 ml of the of the product/kg of live weight product/100 kg of live weight (i.e. 20–40 mg of ketamine/kg (i.e. 2 mg of ketamine/kg of live of live weight) intramuscularly weight) quickly intravenously. Combined anaesthesia: For safe effect of ketamine is 0.1–0.2 ml of the product/kg of required sedave premedicaon live weight (i.e. 10–20 mg of e.g. acepromazin 0.1 mg/kg ketamine/kg of live weight) of live weight, then guaifenesine intramuscularly 90–120 mg/kg of live weight or xylazine 0.4–0.6 mg/kg of live weight i.v.

157 13 Anaesthecs

Ketamine is used with other agents for sedaon, analgesia and total dissociave anesthesia

NARKAMON 50 mg/ml soluon for injecon Ketamine

COMPOSITION extended in all domesc animals and persists for 10–15 minutes. 1 ml of the product contains by a repeated administraon Cat: For sedaon, 5–10 mg/kg bw ketaminum 50 mg of 1/3 to 1/2 of the inial dose to examine and treat the animal Clear colourless soluon for at the me of first signs without any pain. For general injecon. of awakening. anaesthesia, 20–25 mg/kg bw TARGET SPECIES Horse: Xylazine 1.1 mg/kg bw intramuscularly. To reduce Horse, calf, sheep, goat, dog, cat, slowly intravenously, aer the percentage of side ketamine feline, monkey, ape, antelope, the onset of intensive sedaon manifestaons and to achieve deer, roe deer, bird of prey, ketamine is administered in relaxaon, the following parrot, pigeon, reple, mouse, a dose of 2.2 mg/kg bw quickly procedure is recommended: rat and guinea pig. intravenously within 2 minutes. atropine 0.05 mg/kg bw + Calf, sheep, goat: Atropine xylazine 0.5 mg/kg bw INDICATIONS 0.1–0.2 mg/kg bw subcutaneously (or diazepam As monoanaesthec (separately) intramuscularly, 10–15 minutes 0.25–0.5 mg/kg bw in cats for diagnosis, treatment later ketamine 10 mg/kg bw intramuscularly). 15–20 minutes and minor surgical procedures intramuscularly. later, ketamine 10–15 mg/kg not requiring myorelaxaon Dog: Ketamine in combinaon intramuscularly. Ketamine is (reducing of muscle tension). with xylazine is the most frequent administered intramuscularly In combinaon with tranquilizers method of general anaesthesia (i.m.) or intravenously (i.v.). (sedaves), injecon or in dog. Atropine 0.05 mg/kg bw + WITHDRAWAL PERIOD inhalaon anaesthecs xylazine 1–2 mg/kg bw + (desensizers) for a majority Meat 24 hours, no withdrawal ketamine 10–20 mg/kg bw period for milk. of medium and larger surgeries simultaneously or subsequently in horses, calves, sheep, dogs, intramuscularly. Medium SHELF LIFE cats, zoo animals, small animals, and large dog breeds: atropine Shelf-life 24 months, aer first birds and reples. 0.05 mg/kg bw + xylazine opening the immediate DOSAGE 1–1.5 mg/kg bw simultaneously packaging 28 days. Posology depends on the animal intramuscularly. 5–10 minutes STORAGE species, the method of later, 2 mg/kg bw of 1% ketamine Store below 25 °C. administraon and the required soluon, slowly intravenously. Protect from light. intensity of anaesthesia. Anaesthesia starts aer the PACKAGE The effect of ketamine can be ketamine injecon is terminated 50 ml. 158 13 Anaesthecs

Xylazine is determined to sedaon, analgesia and myorelaxaon in according to dose and combinaon with other substances

ROMETAR 20 mg/ml injecon soluon Xylazinum

COMPOSITION Cale: Dose I: 0.25 ml weight s.c. or i.m. 1 ml contains xylazinum (ut Rometar/100 kg live weight i.m. – Cat: For sedaon: 1 to 2 mg xylazini hydrochloridum) 20 mg sedaon to calm the animal xylazine per kg live weight (i.e. Clear colourless soluon down and for minor procedures 0.05 to 0.1 ml Rometar/100 kg for injecon. in local anaesthesia. live weight) s.c. or i.m. (doses TARGET SPECIES Dose II: 0.5 ml Rometar/100 kg near the upper limit induce Horses, cale, dogs, cats, ZOO live weight i.m. – medium respiratory depression) aer animals (red deer, roe deer, sedaon, weak relaxaon and 24 to 36 hours of starvaon and fallow deer). analgesia. The paent is allowed premedicaon with atropine to lie down. (starvaon and premedicaon INDICATIONS Dose III: 1 ml Rometar/100 kg must not be omied). Voming Sedaon prior to medical live weight i.m. : very strong or urge to vomit are frequent examinaon or not very painful sedaon with appreciable during the starng phase of the procedures (transfer, weighing, depression of the CNS, long- effect. In combinaon with X-raying, cloven hoof treatment, lasng myorelaxaon and injecon anaesthecs (typically foreign maer removal from medium analgesia, well suited ketamine) for inducing total the throat of a big animal, ...). to the majority of surgeries on anaesthesia in preparaon Prior to painful procedures a lying paent (local anaesthesia for the majority of surgeries. in combinaon with local can be applied in addion if anaesthecs. WITHDRAWAL PERIOD appropriate). Meat from cale and horses: DOSAGE Dose IV: 1.5 ml Rometar/100 kg 1 day. Milk from cale: Horse: Use Rometar alone at live weight i.m. – induces total No withdrawal periods. doses of 0.6 to 1 mg xylazine per anaesthesia with pronounced kg live weight (i.e. 3–5 ml side effects (bradypnoea, SHELF LIFE Rometar/100 kg live weight). bradycardia, tympanites, Shelf-life 24 months, aer the The combinaon which is most salivaon). first opening of the immediate frequently used for short Dog: For sedaon: 1 to 3 mg packaging 28 days. procedures on a lying paent is xylazine per kg live weight (i.e. STORAGE as follows: xylazine 1.1 mg/kg live 0.05 to 0.15 ml Rometar per kg Store below 25 °C. weight slowly i.v., in 2–3 minutes live weight) i.m. following 24 hr Protect from light. followed by ketamine 2.2 mg/kg starvaon and premedicaon PACKAGE live weight rapidly i.v. with atropine 0.05 mg per kg live 50 ml. 159 13 Anaesthecs

Sedaon for ﬁxaon prior to examinaon and during treatment Sedaon before animal transport (reducon of transport stress)

COMPOSITION DOSAGE Acve substance: HORSE: Acepromazine 35.0 mg Degree Acepromazine dose Number TARGET SPECIES of sedaon [mg/kg bw] of divisions Horses, dogs. Mild 0.1–0.2 2–3 divisions per animal INDICATIONS Moderate 0.3–0.4 4–6 divisions per animal Sedaon of animals for reasons FOAL: of restlessness, nervousness, Degree Acepromazine dose Number tetanus, lumbago of sedaon [mg/kg bw] of divisions - Sedaon for ﬁxaon prior to Mild 0.3–0.5 1–1.5 divisions per animal examinaon and during Moderate 0.7–1.0 2–3 divisions per animal treatment DOG: - Sedaon before animal Degree Acepromazine dose Number transport (reducon of transport of sedaon [mg/kg bw] of divisions stress) Mild 1.0 0.5 divisions/17.5 kg bw - Also acts as an anemec Moderate 2.0 1 divisions/17.5 kg bw (at narcosis, travelling) Deep 3.0 1.5 divisions/17.5 kg bw - Aer serious surgeries when the 0.5 division corresponds to 0.5 ml on the applicator plunger scale. animal needs to be kept in a state Not intended for food-producing animals. of sedaon for a longer me The eﬀect of acepromazine aer oral administraon occurs WITHDRAWAL PERIOD STORAGE in 30–60 minutes in large animals Meat from cale and horses: Store below 25 °C. and in 15–25 minutes in small 1 day. Milk from cale: Protect from frost. animals. No withdrawal periods. Its duraon of acon is 4 hours PACKAGE on average. SHELF LIFE 10 ml. Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

160 13 Anaesthecs

Injectable product for sedaon, myorelaxaon and analgesia with higher concentraons of xylazine intended for horses and cale

XYLASED 100 mg/ml soluon for injecon Xylazinum (as xylazine hydrochloride)

COMPOSITION Recommended doses WITHDRAWAL PERIOD 1 ml of the soluon for injecon for individual routes Cale: Meat: 3 days. contains: of administraon: Milk: 36 hours. Acve substance: Xylazine (as i) Intravenous administraon: Horse: xylazine hydrochloride) 100.0 mg 0.03–0.1 ml of the product/ Do not use in horses the meat Clear, colourless soluon, 100 kg bw, which is equivalent of which is intended for human free of visible parcles. to a xylazine dose consumpon. INDICATIONS of 0.03–0.1 mg/kg bw Do not use in horses the milk Cale: ii) Intramuscular administraon: of which is intended for human Sedaon, myorelaxaon and 0.05–0.3 ml of the product/ consumpon. analgesia for small surgeries. 100 kg bw, which is equivalent SPECIAL STORAGE Horse: to a xylazine dose PRECAUTIONS Sedaon and myorelaxaon. of 0.05–0.3 mg/kg bw Keep out of the reach of children. Horse Protect from frost. Keep the vial TARGET SPECIES Method of administraon: Single Cale, horses. in the carton in order to protect slow intravenous administraon. from light. Do not use aer the DOSAGE FOR EACH SPECIES, Recommended dose: 0.6–1 ml expiry date which is stated on ROUTE(S) AND METHOD OF of the product/100 kg bw, which the packaging. ADMINISTRATION is equivalent to a xylazine dose Shelf life aer ﬁrst opening the Cale of 0.6–1.0 mg/kg bw immediate packaging: 28 days. Method of administraon: Single slow intravenous or PACKAGE: intramuscular administraon. 1 × 10 ml, 1 × 50 ml When administered intramuscularly, the product may be applied by injecon or tranquiliser shot.

161 13 Anaesthecs

Fast sedaon, good myorelaxaon and transional analgesia

XYLASED 500 Xylazinum lyophilizate for soluon for injecon with solvent

COMPOSITION – 10 ml of solvent to prepare within 2 hours aer Xylazinum (ut Xylazini 5% soluon administraon. hydrochloridum) 500 mg – 5 ml of solvent to prepare Red deer, fallow deer, roe deer: Solvent: Water for injecon 10% soluon The onset of effect is established INDICATION – 2 ml of solvent to prepare at 5 minutes, the duraon of Cale: Sedaon, myorelaxaon 25% soluon effect is about 20 minutes and and analgesia at small surgeries; Effect in target species: the normal condion is restored within 2–3 hours aer premedicaon before general Cale: The rate of effect depends administraon. anaesthesia. Horse: sedaon and on an administered dose. The Horse: At intravenous applicaon myorelaxaon; premedicaon analgesic and anaesthec effect the dose should be applied before general anaesthesia is growing with an increasing slowly, for 1–2 minutes. TARGET SPECIES dose. Aer intramuscular Cale, horse, red deer, fallow administraon, the onset of WITHDRAWAL PERIOD deer, roe deer sedaon is established at Cale: meat 3 days, milk 3 milkings. DOSAGE 5 minutes, with duraon of The product may be prepared 30–60 minutes. When a dose is SHELF LIFE in 3 different concentraons increased, deep sedaon and 24 moths, aer the dissoluon (5%, 10%, 25%), using different marked analgesia occur, the immediately amounts of solvent (10 ml, 5 ml, recovery phase is prolonged STORAGE 2 ml). Dissolve the lyophilizate to 1–2 hours. Keep out of the reach and sight in a quanty of solvent according Horse: Aer intravenous of children. Store below 25 °C. to the required concentraon administraon, the onset of Protect from light. xylazine effect is fast, within of soluon. PACKAGE 1 minute. The effect persists 5% and 10% soluons are 1 × 500 mg + 1 × solvent (2 ml) for 15–20 minutes, the recovery recommended for injecon (to prepare 25% soluon), phase is 10–15 minutes. Normal applicaons, 25% soluon 1 × 500 mg + 1 × solvent (10 ml) condion is restored within for a narcozing shot. (to prepare 5%, 10%, 25% 1 hour. Aer intramuscular Always measure in a syringe soluon) a respecve volume of solvent administraon the onset period is for the reconstuon prolonged to 10–15 minutes and of lyophilizate: the normal condion is restored

162 ANALGETICS

MELOXICAM BIOVETA 5 mg/ml 14 MELOXICAM BIOVETA 1.5 mg/ml 14 Analgecs

NSAID analgesic in injectable form for subcutaneous and intravenous administraon

Meloxicam Bioveta 5 mg/ml soluon for injecon for dogs and cats COMPOSITION DOSAGE Cats Acve Substance: Canine indicaon of alleviaon Meloxicam 5 mg/ml i) indicaon of musculoskeletal of post-operave pain TARGET SPECIES system involvement Subcutaneous administraon. Dogs and cats. Subcutaneous administraon. Single administraon at 0.3 mg Single administraon 0.2 mg meloxicam/kg bw., which INDICATION meloxicam/kg bw., which corresponds to a soluon dose Canine corresponds to a soluon dose of of 0.06 ml/kg bw. Alleviaon of inflammatory 0.4 ml of the formulaon/10 kg Apply 30–45 minutes before response and pain associated bw. surgery. with both acute and chronic MELOXICAM Bioveta 1.5 mg/ml musculoskeletal involvement. SHELF LIFE oral suspension at a dose of Shelf life of the veterinary Alleviaon of post-operave pain 0.1 mg meloxicam/kg body and inflammaon aer medicinal product as packaged weight can be used 24 hours aer for sale: 2 years. orthopedic and so ssue injecon to connue treatment. surgery. Shelf life aer first opening: 28 days. Cats ii) indicaon of post-operave Alleviaon of post-operave pain pain relief PACKAGE SIZE aer ovariohysterectomy and Intravenous or subcutaneous 10 ml minor so ssue surgery. administraon. Single administraon at 0.2 mg meloxicam/kg bw. weight, which corresponds to a soluon dose of 0.4 ml/10 kg body weight. Apply 30 minutes before surgery.

164 14 Analgecs

NSAID analgesic and an- inﬂammatory peroral suspension for dogs

Meloxicam Bioveta 1.5 mg/ml oral suspension for dogs MELOXICAM IN SUSPENSION DOSAGE SHELF LIFE FOR LONG TERM USE Inial treatment is a single dose Shelf life of the veterinary COMPOSITION of 0.2 mg meloxicam/kg body medicinal product as packaged Acve Substance: weight, i.e. 1 ml of the for sale: 2 years. Meloxicam 1,5 mg/ml product/7.5 kg bw on the first Shelf life aer first opening: day. Treatment should be 6 months. TARGET SPECIES connued with administraon Dogs. of a maintenance dose of 0.1 mg PACKAGE SIZE INDICATION meloxicam/kg body weight, i.e. 10, 100 ml Canine: 1 ml of the product/15 kg bw The 10 ml pack contains a 1 ml Alleviaon of inflammatory once daily at 24-hour intervals. oral applicator. response and pain associated For longer term treatment, once The 100 ml pack contain 2 oral with both acute and chronic a clinical response has been applicators of 1 ml and 5 ml. musculoskeletal involvement observed (aer ≤ 4 days), the in dogs. dose of the product can be adjusted to the lowest effecve individual dose reflecng that the degree of pain and inflammaon associated with chronic musculoskeletal disorders may vary over me. Parcular aenon should be paid to accurate dosing. Oral administraon, in feed or directly into the animal's mouth. Shake well before use.

165 14 Analgecs

166 INTRAMAMMARY

GAMARET INTRAMAR LC 15 LINEOMAM LC 15 Intramammary

Product for treatment acute and chronic mass during lactaon with the unique anbioc Novobiocinum

GAMARET intramammary suspension

COMPOSITION DOSAGE WITHDRAWAL PERIODS 1 applicator 10 ml contains: The content of one applicator Meat 7 days, milk – 72 hours Procaini benzylpenicillinum (10 ml of the preparaon) is (6 milking). monohydricum 100 mg administered to the aﬀected SHELF LIFE Neomycini sulfas 102 000 IU quadrant. Before the preparaon Shelf-life in an intact package: Dihydrostreptomycini is administered the lacteal glands 18 months sulfas 91 250 IU are milking and thoroughly Novobiocinum cleaned and disinfected using STORAGE natricum 100 mg enclosed cleaning wipes. Store below 25 °C and keep in dry Prednisolonum 10 mg Administraon method: place and protect for light. Do not freeze. TARGET SPECIES The preparaon is intended only Cale – milking cows in lactaon for intramammary use. Shake PACKAGE period. well before use. Udder and teats 10 ml plasc applicators are washed as required with (packaging 20 applicators INDICATIONS warm water and thoroughly in paper box). Treatment of acute and chronic dried. The ends of teats are mass in cows in the period of disinfected with an appropriate lactaon caused by micro- agent and aer removing the organisms suscepble to plasc cover of the applicator's novobiocin, penicillin, p is the applicator inserted to dihydrostreptomycin and the teat duct. The content is neomycin. administered to the udder by pressing the piston. Aer the administraon is the parcular quadrant massaged in order to ensure a beer distribuon of the preparaon into milk cisterns. If required by the situaon, it is possible to repeat therapy aer 24–48 hours.

168 15 Intramammary

Product for mass treatment with the broad- spectrum eﬃcacy against major bacterial pathogens of mammary gland

INTRAMAR LC intramammary suspension

COMPOSITION CHARACTERISTIC AND WITHDRAWAL PERIODS 1 applicator (4 g) contains : INDICATION Meat 7 days, milk 84 hours Amoxicillinum (ut amoxicillinum The product is intended for the (7 milking). trihydricum) 200.00 mg treatment of mass in lactang SHELF LIFE Acidum clavulanicum dairy cows. The product contains Shelf-life in an intact package: (ut kalii clavulanas) 50.00 mg a broad spectrum anbioc 18 months Prednisolonum 10,00 mg amoxicillin and clavulanic acid potenced with corcosteroid STORAGE TARGET SPECIES Store below 25 °C and keep in dry Cale. prednisolone, which suitably modulates the inflammatory place and protect for light. response. Product is indicated for Do not freeze. the treatment of environmental PACKAGE and contagious mass caused Each applicator is provided with by bacteria sensive to beta- a self-adhesive label is sealed lactam anbiocs, including the in PE foil with four pieces. strains producing beta-lactamase, Shipping box of 24 pcs of especially species: applicators (6 × 4 pcs) is inserted Staphylococcus spp. including into a box along with a leaflet. coagulate-negave strains , Streptococcus spp. (especially S. agalacae, S. dysgalacae, S. uberis), Enterococcus spp. Administraon method: The product is administered immediately aer milking. In each affected district serves a total of 3 doses at 12-hour intervals.

169 15 Intramammary

Product for mass treatment caused by bacteria suscepble to a combinaon of lincomycin and neomycin anbiocs

LINEOMAM LC intramammary soluon

COMPOSITION AMOUNTS TO BE the teat canal, press the plunger 1 applicator of 10 ml contains: ADMINISTERED AND and dispense the enre contents Lincomycinum (ut ADMINISTRATION ROUTE of the applicator into the affected hydrochloridum) 330 mg Intramammary administraon. quarter. It is recommended the Neomycin sulfate 100,000 IU For one dose, the contents teat be massaged briefly, away Intramammary soluon. Clear, of 1 applicator is administered from the p of the teat towards colourless to yellowish soluon. to each affected quarter, i.e. the milk cistern, following TARGET SPECIES 100,000 IU neomycin sulfate applicaon. Dairy cows during lactaon. and 330 mg lincomycin. A total Each applicator is intended of 3 doses is applied to each for single use only. INDICATIONS FOR USE, affected quarter. Doses are WITHDRAWAL PERIODS SPECIFYING THE TARGET applied at 12-hour intervals. SPECIES Meat: 3 days. Administer the product by Milk: 84 hours. Treatment of mass caused by intramammary infusion only, bacteria suscepble to a taking asepc precauons. Apply SHELF LIFE combinaon of lincomycin and to a clean, washed and Shelf life of the veterinary neomycin in dairy cows during thoroughly dried udder, as soon medicinal product as packaged lactaon. Bacteria generally as possible aer milking the for sale: 2 years. suscepble to lincomycin and/or treated quarter. Prior to Intended for immediate use aer neomycin are bacteria of the applicaon, disinfect the end of first opening. genus Staphylococcus spp., the teat using one of the STORAGE including S. aureus, the genus disinfectant wipes provided (use Do not freeze. Protect from light. Streptococcus spp. including a new wipe for each teat!). S. agalacae, S. dysgalacae and PACKAGE Prior to applicaon, hold the 24 × 10 ml, package includes S. uberis, and coliform bacteria, applicator with the cannula including E. coli. 24 disinfectant wipes moistened pointed upward and remove with 65% v/v isopropyl alcohol USE DURING PREGNANCY AND the cap from the cannula in this soluon LACTATION posion. Immediately aer Can be used during pregnancy opening, insert the cannula into and lactaon.

170 VITAMINS

MINERALS

ADE - vit. ENERGY BOOSTER BIOVETA FRESH HORSE PASTE KELPA BIOVETA MULTIVIT – MINERAL PLASTIN VITA E SELEN 16 VITAPLASTIN FORTE 16 Vitamins, minerals

Oily injecon product containing vitamins A, D2 and E

ADE - vit. injecon soluon

COMPOSITION period, oligospermia, lack of STORAGE 1 ml of injecon soluon libido sexualis in males, Store in a refrigerator contains: myodystrophy in lambs and (2 °C – 8 °C), protect from frost, Renoli propionas 100 000 IU calves, vitamin supplementaon keep in dry and dark place. Ergocalciferolum 100 000 IU in the period before parturion PACKAGE Tocoferoli alfa acetas 30 mg and in newborn animals, 50 ml, 100 ml in glass vial, 500 ml TARGET SPECIES especially in exposed hygiene and in plasc HDPE bole. Cale, horses, pigs, sheep, goats, dietary condions. dogs, rabbits. DOSAGE INDICATIONS Cale, horse 5–10 ml Hypovitaminosis and avitaminosis Calf, pig, foal 3–7 ml A, D2 and E, growth and Piglet, lamb, kid 1–3 ml metabolic disorders in young Rabbit 0.1 ml domesc animals, increased Dog 0.1 ml/5 kg suscepbility to infecous of the body weight diseases of the respiratory and In severe cases, repeat 2–3 mes the digesve systems; in half doses in 2-day intervals. hemeralopia, xerophthalmia, METHOD OF ADMINISTRATION keratomalacia, epithelial Intramuscularly. alteraons, acne, hyperkeratoc eczema, rickets, osteomalacia, WITHDRAWAL PERIOD disorders caused by low calcium None. level in the body, promong bone SHELF LIFE fractures healing and proper Shelf-life 2 years. tooth development, dermas pustulosa. Supporve treatment of sterility of unknown eology, prophylaxis of embryonic mortality and fetal development disturbances during the prenatal

172 16 Vitamins, minerals

Supplementary feed to increase performance of horses

ENERGY BOOSTER BIOVETA oral gel

ENERGY BOOSTER BIOVETA  by supplementaon of TARGET ANIMAL SPECIES provides rapid and reliable supply electrolytes aer excessive Horses. of nutrients, minerals and sweang, mainly during and DOSAGE vitamins important for their aer the procedure. Oral. health and performance and COMPOSITION horse (live weight 500 kg): correct funcon of vital organs Supplementary substances: 20 g (1 applicator) in horses. Paste is easily Vitamin E, vitamin B3, B1, B2, B5, moderate horse breeds: administered with an oral B6, B12, iron as sulphate 10 g (1/2 applicator) applicator and due to suitable heptahydrate, zinc sulphur small horse breeds: technological processing. heptahydrate, methionin, L – 5 g (1/4 applicator) Balanced intake of nutrients, lysine hydrochloride, aspartam, see table below ... electrolytes and vitamins is potassium sorbate, emulgators manifested by: Glucose, saccharose, sodium STORAGE  physical stabilisaon, fast chloride, potassium chloride, Keep out of the reach of children. regeneraon and support calcium gluconate, magnesium Keep at a temperature bellow of appete with group B hydrogenphosphate 25 °C. Protect from light. vitamins, Suspension-emulsion preparaon Keep in dry place.  regulaon of blood cells with an applicator in a form of SHELF LIFE producon and myoglobin by paste containing highly 2 years. iron, concentrated and rapidly PACKAGE available nutrional substances,  1×20 g. rapid return to full electrolytes and vitamins. performance capacity and increased will for performance due to metabolic opmisaon Daily dose Time period of essenal amino acids, General 20 g 2 mes weekly  by the opmisaon of smuli To improve condion of the horse ll recovery acvaon in nerve endings by Racing horses 20 g 2–5 hours before means of minerals and During extreme short-term race and aer electrolytes, exeron (training, races)

173 16 Vitamins, minerals

Oral gel for respiratory support and against muscle fague of the horse

FRESH HORSE oral gel

INDICATION TARGET ANIMAL SPECIES STORAGE Product with a unique Horses. Store at temperatures below combinaon of LACARTIN 5 DOSAGE AND METHOD OF 25 °C. acve substances containing oils ADMINISTRATION Protect from frost. of peppermint, anis and The applicator contains SHELF LIFE eucalyptus to facilitate and one dose – 12.4 g. 2 years. support breathing, and L-carnin Administer one applicator PACKAGE to spare muscle glycogen and 15–25 minutes before mounng 1 × 12.4 g reduce lactate build-up in the horse (show jumping, race muscles causing muscle fague. horses, reining, dressage, etc.). The medicinal product comes in In other cases 15–25 minutes the form of sweet, tasty and easy- before starng the sports to-administer gel. performance of the horse. COMPOSITION Squeeze the applicator contents 1 applicator contains: at the back of the tongue by L-carnin 4.5 g, peppermint oil, single pushing the piston. anise oil, eucalyptus oil, silicon This medicinal product does not dioxide, sucralose, honey, water, contain any doping substances. sodium methylparaben, sodium propylparaben. Before applicaon, remove the cap from the applicator by Oral gel. bending it slightly to one side.

174 16 Vitamins, minerals

Ascophyllum nodosum for healthy teeth and strong imune system

KELPA BIOVETA Veterinary dietary supplement for dogs and cats

COMPOSITION DOSAGE MINIMUM SHELF LIFE Alga Ascophyllum nodosum 90 % Small dog breeds up to 10 kg and By the date indicated on mint (dry leaves) cats – ½–1 measuring cup. the jar label parsley (dry leaves) Dogs from 10 kg to 25 kg – PACKAGE yeast (dry, deacvated) 1–2 measuring cups. 90 g TARGET SPECIES Dogs from 25 kg – 2 measuring Dog, cat. cups. INDICATIONS Measuring cap volume approx. Eliminates bad breath. 0,5 g. Supports the funconing of the STORAGE thyroid gland and the immune In a dry and dark place, in the system.Improves skin and hair original closed container. Keep quality. out of the reach of children. Has anoxidant eﬀects.

175 16 Vitamins, minerals

Well-balanced mineral supplement for broad spectrum of target species

MULTIVIT – MINERAL vitamin, mineral and amino-acid product

COMPOSITION osteomalacia, disorders caused by The upper tolerance of the dose is 1 ml of injecon soluon contains: low calcium level in the organism, maximum for one animal. The dose Renolum – 50 000 IU, Colecalci- support of bone fractures healing can be repeated in 10–14 days. ferolum – 25 000 IU, Vitaminum E – and correct teeth genesis, The recommended dose for oral 4 mg, Thiaminum – 10 mg, dermas pustulosa in piglets, administraon is: Riboﬂavinum – 0,04 mg, neuris, therapy with Calves, foals (50 kg bw) Pyridoxinum – 2 mg, Cyanocobala- chemotherapeucs, 1 ml/8 animal/day minum – 0,01 mg, Dexpanthenolum panmyelopathy, intesnal atonia, Piglets, lambs, kids (5 kg bw) – 2 mg, Acidum niconicum – 5 mg, somnipathy and liver disorders. 1 ml/40 animal/day Inositolum – 2 mg, Methioninum Supporve treatment of sterility Pigs (100 kg bw) racemicum – 5 mg, Cholini citricum without known aeology, 1 ml/4 animal/day – 5 mg, Magnesii hypophosphis prophylaxis of embryonic mortality Horses, cale (500 kg bw) hexahydricus – 1 mg, Cobaltosi and foetus genesis disorders in the 2 ml/1 animal/day chloridum – 0,02 mg, Cupri sulfas – prenatal period, oligospermia, poor METHOD OF ADMINISTRATION 0,1 mg, Zinci sulfas – 0,1 mg libido sexualis in males, The product is administered TARGET SPECIES myodystrophia in lambs and calves; intramuscularly, subcutaneously Cale, horse, sheep, pig, goat, dog, replenishment of vitamin and and orally. piglets, kids, lambs, hens, chickens, mineral reserves before giving birth and at new-born animals, especially WITHDRAWAL PERIOD turkeys and their chickens, ducks, None. ducklings, geese, goslings, pigeons in exposed zoohygienic and dietec and exoc birds. condions. SHELF LIFE Shelf-life 2 years, aer ﬁrst opening INDICATIONS DOSAGE The recommended dose for of the immediate packaging: Hypovitaminosis and avitaminosis 28 days. A, D3 and E and vitamins soluble in intramuscular or subcutaneous administraon is: Aer diluon ( for oral water; growth and metabolism administraon) – 12 hours. disorders in young domesc Cale: 2–6 ml/100 kg bw animals, increased suscepbility to Sheep, pigs, goats: STORAGE infecous diseases of respiratory 1,5–2,5 ml/50 kg body weight Store at temperature at 8–15 °C and digesve systems; hemeralopia, Piglets, kids, lambs: in the dark and dry place. xerophtalmia, keratomalacia, 1–1.5 ml/10 kg body weight PACKAGE epithelial alteraon, acne, Dog: 50 ml, 100 ml, 250 ml and 500 ml hyperkeratoc eczema, rachis, 0,5–5 ml/10 kg body weight in glass vials.

176 16 Vitamins, minerals

Minerals for peroral administraon with vanilla ﬂavor

PLASTIN mineral food complement for pigs, dogs and poultry

COMPOSITION DOSAGE STORAGE Calcium carbonate, calcium Pigs: 5–10 g, i.e. a flat coffee On a dry place, in intact, duly dihydrogen and hydrogen spoon 1–2 mes a day, sealed original packages at the phosphate monohydrate, iron depending on the size. temperature up to 25 °C. sulfate monohydrate, zinc oxide, Piglets: 1–3 mes a day one knife SHELF LIFE zinc and amino acid n-hydrate point to the smallest ones. 36 months. chelate complex, iron and amino 3–5 g per day, i.e. less than or acid n-hydrate chelate complex , a flat coffee spoon once a day. PACKAGE copper(II) oxide (CuO), copper Dogs: 1–5 g per day, i.e. twice 1 kg, 5 kg and amino acid n-hydrate chelate the knife point up to the flat complex manganese (II)oxide, coffee spoon once a day, manganese and amino acid depending on the size. n-hydrate chelate complex, Poultry: 0.5–1.5 g per day, i.e. potassium iodide (KI), vanilla one heaped coffee spoon for flavor 10 hens or for 50–100 chickens Compleon of mineral per day. substances into the feeding dose. Perorally in feed.

177 16 Vitamins, minerals

Product intended for prophylaxis and therapy of diseases caused by the deﬁciency of the vitamin E and selenium

VITA E SELEN soluon for injecon

COMPOSITION DOSAGE 1 ml of injecon soluon Animal species Dose - prophylacc Dose - therapeuc contains: Alpha-tocopherol acetate 25 mg Lambs up to 3 weeks of age 1 ml 2 ml Sodium selenite 2.2 mg Lambs over 3 weeks of age 2 ml 4 ml (equivalent to 1 mg of selenium) Calves, young cale 10 ml/100 kg bw 20 ml/100 kg bw TARGET SPECIES Piglets 1 ml/10 kg bw 2 ml/10 kg bw Lambs, calves, young cale, cows, pigs. Cows (3 weeks before calving) 20 ml INDICATIONS METHOD OF ADMINISTRATION Prevenon and therapy of Intramuscularly into the neck diseases associated with muscles. deficiency of vitamin E and selenium, especially muscular WITHDRAWAL PERIODS dystrophy in young livestock; Meat: 30 days beneficial effect on the Milk: none reproducon of cows. SHELF LIFE Shelf-life 2 years, aer first opening of the immediate packaging: 28 days. STORAGE Store at temperature below 25 °C, do not freeze, protect from light. PACKAGE 50 ml and 100 ml in brown glass vials.

178 16 Vitamins, minerals

Well-balanced mineral supplement for broad spectrum of target species

VITAPLASTIN FORTE mineral food complement

COMPOSITION DOSAGE Rabbits: one knife point once Calcium carbonate,calcium Horses, cale: 30–60 g per day, a day. dihydrogen and hydrogen i.e. one heaped tablespoon Poultry: 0.5–1.5 g per day, i.e. phosphate monohydrate, 1–2 mes a day. In large-capacity one knife point 1–3 mes a day, calcium-magnesium carbonate, breeding farms one ½ liter bole or one flat to heaped coffee iron sulfate monohydrate, of powder 1–2 mes a day per spoon for 10 hens or for iron(III)oxide, zinc oxide (ZnO), each 10–14 cows. 50–100 chickens per day. zinc and amino acid n-hydrate Foals, calves: 10–30 g per day, i.e. Proporonately more to chelate complex, iron and amino a heaped coffee spoon ducklings or goslings, depending acid n-hydrate chelate complex, 1–3 mes a day, depending on their body weight. vanilla flavor, copper(II), copper on the size. Exoc birds: one knife point into and amino acid n-hydrate chelate Sheep, goats: 10 g per day, i.e. a 100 g of so feed. complex, manganese (II)oxide, flat coffee spoon 2 mes a day. STORAGE manganese and amino acid Lambs: 1–3 mes a day one knife On a dry place, in intact, duly n-hydrate chelate complex, point to the smallest ones. 3–5 g sealed original packages at the potassium iodide per day, i.e. less than or a flat temperature up to 25 °C. Compleon of mineral coffee spoon once a day. substances into the feeding dose. Pigs: one flat coffee spoon SHELF LIFE Perorally in feed. 1–2 mes a day, or one heaped 36 months. TARGET ANIMAL SPECIES coffee spoon per each 3 heads, PACKAGE Horses, Cale, Sheep, 3 mes a day /5–10 g/. 1 kg, 5 kg. Goats, Pigs, Dogs, Silver Foxes, Piglets: 1–3 mes a day one knife Rabbits, Poultry and Exoc Birds. point to the smallest ones. 3–5 g per day, i.e. less than or a flat coffee spoon once a day, or one heaped coffee spoon per each 3 heads, 1–2 mes a day. Dogs, silver foxes: 1–5 g per day, i.e. one knife point 2 mes a day, up to one flat coffee spoon once a day.

179 16 Vitamins, minerals

180 17 Joint nutrion JOINT NUTRITION

Atlet BS Atlet MSM Atlet syrup HYALCHONDRO DC Plus HYALCHONDRO EC Plus 17 HYALURONAN BIOVETA 10 mg/ml 17 Joint nutrion

Complete joint nutrion with natural Boswellia serrata extract to alleviate inﬂammaon and pain

ATLET BS oral powder Complete joint nutrion

COMPOSITION DOSAGE Acve substance content per kg: Horse Initial dose Maintenance (boost) dose Glucosamine sulfate 400 g weight (first 14 days of using) daily daily Hydrolyzed collagen 300 g Chondroin sulfate 150 g Boswellia serrata extract 65 g Sodium hyaluronate 9 g TARGET SPECIES Horses. INDICATIONS - Nutrion, protecon and regeneraon of joint carlages and ssues - Alleviaon of musculoskeletal SHELF LIFE pain 2 years. - Improved movement and STORAGE greater physical performance Store below 25 °C. - Slowing down to stopping Protect from light and frost. further joint carlage damage Keep out of the reach of children. - Longer acve life of the animal PACKAGE - Improved general health 600 g.

During strenuous physical exercise, to keep a good funcon of the musculoskeletal system. Aer orthopaedic surgeries, against osteoarthris and musculoskeletal pain.

182 17 Joint nutrion

Unique, proven combinaon of glucosamine, chondroin and MSM. Helps ensure carlage integrity and reduce the risk of carlage damage

ATLET MSM oral powder Complete joint nutrion

COMPOSITION DOSAGE Acve substance content per kg: Horse Initial dose Maintenance (boost) dose Glucosamine sulfate 355 g weight (first 14 days of using) daily daily

Chondroin sulfate 133 g 4.5 g 2.25 g MSM 9.0 g 4.50 g Methylsulfonylmethane 444 g 13.5 g 6.75 g TARGET SPECIES 18.0 g 9.00 g Horses. 22.5 g 11.25 g INDICATIONS 27.0 g 13.50 g - Foals from 2 months of age - To prevent musculoskeletal diseases Administer the powder with a SHELF LIFE - Sport and working horses of all piece of food, mixed in grain or 2 years. age categories molasses, or give right into the STORAGE mouth. Animals usually accept Store below 25 °C. - Nutrion, protecon and the product without problems. Protect from light and frost. regeneraon of joint carlages Keep out of the reach of children. and ssues PACKAGE - Alleviaon of musculoskeletal 700 g. pain - Improved movement and greater physical performance - Slowing down to stopping further joint carlage damage - Longer acve life of the animal - Improved general health

183 17 Joint nutrion

To relieve inﬂammaon and pain. To protect and regenerate the locomotor system of dogs and cats. Syrup for oral administraon.

ATLET syrup for dogs and cats Chondroprotecve for dogs and cats

COMPOSITION DOSAGE SHELF LIFE 100 ml of the syrup contains: Recommended daily dose: 2 years. Hydrolysed collagen 14 000 mg Dog: 0–10 kg 2.5 ml STORAGE Glucosamine 10–20 kg 5 ml Store below 25 °C. Protect from sulfate.2KCl 4 000 mg 20–40 kg 10 ml light and frost. Aer first opening MSM 40–60 kg 15 ml use within 3 months. Keep out (dimethylsulfone) 2 400 mg Cat: 2.5–5 ml of the reach of children. Chondroin sulfate 2 400 mg Hyaluronic acid 200 mg Administer the daily dose directly PACKAGE Cranberry extract 120 mg into the mouth or mixed with 250 ml. Boswellia serrata food. extract 100 mg The duraon of administraon Excipients: depends on the diagnosis and the Fructose, sucralose, polysorbate effect of the product. When using 20, citric acid monohydrate, the product for prevenve potassium sorbate, flavour protecon of the locomotor TARGET SPECIES system, administer daily for 3 Dogs, cats. months, skip the next month and repeat 3 months of therapy. INDICATIONS When using the product for To protect and regenerate the diagnosed damage of the locomotor system of dogs and locomotor system, administer cats. Syrup for oral permanently. administraon.

184 17 Joint nutrion

A high complementary feed supplement providing a painless aid for maintaining healthy joints THE PRODUCT DOES NOT CONTAIN ANY DOPING SUBSTANCES!

HYALCHONDRO DC Plus food supplement for dogs

 for all puppies up to three INDICATION manganese. The unique months of age to forfy and Food supplement is specifically combinaon of the support healthy development intended to support correct aforemenoned substances of the locomotor system, development and funcon of the ensures, apart from the support  for all breeds of dogs to locomotor system in all dog of correct development and increase resistance during sport species. It is used in case of funcon of the locomotor and work acvies, since the increased demands on the system, also the improvement unique combinaon of HCK with locomotor system of the dogs in of the physical condion of the manganese posively influences the period of growth, in case of dogs, it also increases resistance metabolism of collagen, training and working exeron, of the organism during exeron, producon of body connecve aer injuries to support and during growth, training and aer ssues, mainly formaon of restore funcon of the locomotor previous joint disorders. carlage,for all older dogs and system. It is appropriate to use RECOMMENDED DOSAGE dogs aer an injury since the product also in older dogs Up to 10 kg 1 ml/day combinaon of HCK with vitamin and in dogs in recovery aer 10–30 kg 2 ml/day E and manganese increases the injuries or in the period aer 30–50 kg 3 ml/day resistance of the organism during previous joint procedure or 50–70 kg 4 ml/day stress condions and posively operaon, where the usage Single dose before feeding or influences the course of of the product results in higher together with feed for a period osteoarthris therapy quality and longer acve life of 30 days connuously. of the dog. The main acve COMPOSITION SHELF LIFE Hyaluronan – chondroin ingredient of the product is hyaluronic acid together in 24 months, aer the first opening complex, invert sugar with 6 months. reduced glycemic index (glucose, a complex with chondroin fructose), vitamin E (as DL-alpha sulphate. The maximal efficiency STORAGE tocopherol acetate), manganese of the product is ensured with Keep at a temperature below (in the form of manganese higher concentraon of two main 25 °C. Protect from light. sulphate, monohydrate), components of the joint PACKAGE stabilisers. nutrion. The product is also 120 ml. Peroral emulsion. enriched with vitamin E and

185 17 Joint nutrion

A food supplement improving quality of the joint carlage for painless movement THE PRODUCT DOES NOT CONTAIN ANY DOPING SUBSTANCES!

HYALCHONDRO EC Plus food supplement for horses

COMPOSITION locomotor system of horses, in DOSAGE Peroral emulsion the period of growth to In order to achieve a maximal Hyaluron – Chondroin – strengthen and support quality effect, it is recommended to Complex with manganese and development of the locomotor administer the preparaon at vitamin E. A unique food system, in case of training or least for a period of 30 days, best supplement supporng work strains, aer injuries and before the morning feeding or development and maintaining aer operaons on the together with feeding. The healthy locomotor system in all locomotor system. It may be used product may be administered categories of sport and labour in all age categories of horses. throughout the whole year; we horses and ponies A unique combinaon with recommend at least one to two HYALCHONDRO EC plus is manganese posively influences 30-day cycles a year depending suitable especially for: the metabolism of collagen, on the exeron of the horse. sport, racing and saddle horses producon of connecve ssue in All categories of horses prior to the iniaon and during the body, especially formaon of the season, young horses and carlage. Vitamin E has a posive 15 ml / day ponies to support healthy effect on the course of Connually for a period development of the locomotor osteoarthris and also acts as of 30 days system. labour breeds and older a strong an-oxidant protecng All categories of ponies horses to extend acve age. the body against free radicals. 10 ml / day all horse breeds in the period of Vitamin E also increases the Connually for a period recovery aer a previous disease resistance of the organism during of 30 days or surgical procedure on the strenuous condions during the locomotor system. period of growth and training. SHELF LIFE INDICATION The product may be administered 2 years. Use within 6 months Food supplement is specifically during the whole year. It is aer 1st opening. intended to support correct intended for all sport, racing and STORAGE development and funcon of the labour breeds of horses, possibly Keep at a temperature below locomotor system in all horse for ponies, as well as to older 25 °C. Protect from light. horses to extend their acve age. breeds. It is used in case of PACKAGE increased demands on the 2×225 ml.

186 17 Joint nutrion

A low molecular hyaluronan for rapid eﬃcacy of safe intravenous administraon

HYALURONAN BIOVETA 10 mg/ml soluon for injecon

COMPOSITION DOSAGE SHELF LIFE 1 ml of the soluon for injecon Method of administraon: Shelf life of the veterinary contains sodium 1) Intravenous (subcutaneous) medicinal product in intact hyaluronate 10 mg administraon package: 2 years. The product Soluon for injecon. a) Horses: must be used immediately aer Clear colourless fluid. Dose: usually 6 ml (60 mg). first opening of the immediate TARGET SPECIES Number of doses: 3–7 doses, packaging. Horses, dogs, cats. opmum 5. STORAGE Interval between doses: Store at a temperate below 25 °C. INDICATIONS 3–9 days, opmum 7. Orthopaedic: Protect from light. Do not freeze.  Acute and chronic b) Dogs, cats: PACKAGE osteoarthris, Dose: slightly lower, usually 5 × 6 ml. polyosteoarthris, subacute 3–5 ml. and chronic arthris Number of doses: 3–7 doses,  Acute and chronic opmum 5. tendovaginis, tendinoses and Interval between doses: bursis 3–9 days, opmum 7.  Osteochondroses 2) Topical administraon to the Ophthalmologic: conjuncval sac:  Acute and chronic keras Dose/number of doses:  Conjuncvis, 1–2 drops to the eye keratoconjuncvis (conjuncval sac) every  Dry keratoconjuncvis 2–12 hours.  Corneal ulcer, corneal Period of administraon: injury 5–60 days, possibly permanently (acute inflammaon 5–7 days, chronic inflammaon unl improvement/cure).

187 188 18 Dermatologics DERMATOLOGICS

ALAPTID BIODEXIN ear loon BIODEXIN shampoo BIOPIROX 10 mg/ml OTIBIOVIN ear drops, soluon OTIMIX ear drops, suspension OTIPUR ear drops, soluon OTOFIN 18 PIX - FAGI 18 Dermatologics

Original dermatologic with wound healing eﬀects

ALAPTID® veterinary ointment

COMPOSITION INDICATION STORAGE Composion 100 g: A cosmec veterinary product, Store at the temperature Alapdum – 1 g which can be used in all warm- from 10 °C to 25 °C. Excipients – Polysorbate 60, blooded non-food animals to SHELF LIFE Cetostearyl alcohol, Paraﬃn treat mild injuries to the skin and 36 months, aer the ﬁrst opening liquid, Propylene glycol, Methyl mucous membranes, burns, 28 days. parahydroxybenzoate, Propyl excoriaons, frost bites, pressure parahydroxybenzoate, Water for ulcers, acid burns in canine PACKAGE injecons. footpads from salt in the winter 1 × 20 g. CHARACTERISTICS OF THE period, etc. MEDICINAL PRODUCT DOSAGE Alapde (spirocyclic synthecally Externally on skin. Apply the prepared dipepde) smulates ointment in a layer of 2–3 mm the growth of granulaon ssue, on the skin site; possible slightly accelerates the epithelisaon wrap with a bandage and keep process and the course of wound on site for the required period healing. to support wound healing with occasional controls. In cases, when bandage cannot be used, the ointment is applied 2 mes a day or as required. The applicaon period depends on the extent of injured site and the regeneraon state. The usual applicaon length varies from 3 – 10 days; longer in chronic neglected cases.

190 18 Dermatologics

Anbacterial and anmycoc acve agent chlorhexidin digluconate soluon 0.1 % and essence of Melaleuca alternifolia acng against bacteria and yeasts Malassezia pachydermas

BIODEXIN ear loon soluon

COMPOSITION DOSAGE SHELF LIFE 100 ml of the product contains: Apply 5–8 drops into dog ears. 24 months. Chlorhexidine digluconate Rub the auditory canal and let STORAGE soluon 0.5 ml, Australian tea the dog shake the medicinal Store in the original container. tree oil, dexpanthenol, propylene product out. Possible residues Store below 25 °C. glycol, Cremophor RH 40, of the medicinal product and Protect from light and frost. phenoxyethanol, ethylhexyl earwax can be removed by glycerol, alpha tocopherol, acec a coon swab. The procedure PACKAGE acid 99%, sodium acetate can be repeated twice a day. 100 ml. trihydrate, puriﬁed water. If the symptoms are not Ear soluon. improved, seek help from a veterinarian. TARGET SPECIES Dog. INDICATION The product is intended for applicaon into the external auditory canal of dogs.

191 18 Dermatologics

The product contains four percent of the very acve ansepc agent called chlorhexidine

BIODEXIN shampoo

COMPOSITION TARGET ANIMALS DOSAGE 100 ml of the medicinal product Dog, cat. Apply small amount of the contains: medicinal product uniformly on Chlorhexidine digluconate The medicinal product contains the wet animal hair, massage soluon, decyl glucoside, soluon of the ansepc unl foam is created. Let act for cocoamidopropyl betaine, substance chlorhexidine 5–10 minutes, then flush the sodium chloride, cocamine oxide, in the shampoo base. Thanks to animal by water thoroughly. PEG-7 glyceryl cocoate, laureth-4, a strong ansepc effect the Washing can be repeated in PEG/PPG-120/10 medicinal product can be used, several days, if necessary. When trimethylolpropane trioleate, where the washing, ansepc handling the animal, prevent eye laureth-2, glycerol 85%, benzyl and deodorant effect has to be contact with the medicinal alcohol, combined. product. methylchloroisothiazolinone, INDICATION In case of accidental eye contact, methylisothiazolinone, acec acid Intended for washing coat and flush eyes with clean water flow. 99%, Briliant Blue FCF, purified skin of dogs and cats, where the STORAGE water. ansepc, cleaning and Store below 25 °C. Store in a well deodorant effect is needed. sealed primary container. Protect from light. Protect from frost. SHELF LIFE 24 months. PACKAGE 250 ml, 500 ml.

192 18 Dermatologics

No mutagenic, teratogenic, carcinogenic eﬀects have been reported

BIOPIROX 10 mg/ml cutaneous spray, soluon Piroctolamine

COMPOSITION DOSAGE SHELF LIFE 1 ml of the product contains The product should be applied 24 months. piroctolamine 10 mg/g to aﬀected sites by spraying from STORAGE Cutaneous spray, soluon. a distance of 10–20 cm, at least Store below 25 °C. Clear to slightly opalescent 4 mes in 2 to 4-day intervals Do not freeze. soluon. unl disappearance of clinical symptoms. PACKAGE TARGET SPECIES 100 ml. Dog, cat, non-food furry animals The highest daily dose and the and small non-food animals. maximum dose for the whole treatment: INDICATION It is recommended to apply the Treatment of fungal skin diseases product repeatedly not earlier caused by dermatophyte fungi in than 2–4 days aer the ﬁrst dogs, cats, furry and small applicaon and to one quarter animals. of the body as a maximum. Method of administraon – dermal, by spraying.

193 18 Dermatologics

Logically ﬁrst step in management of the os externa in dogs and cats

OTIBIOVIN ear drops soluon

COMPOSITION DOSAGE SHELF LIFE Composion – 1 ml: Apply 4–5 drops of the product 24 months, aer ﬁrst opening the Triamcinoloni into the ear canal 3 to 4 mes immediate packaging 12 days. acetonidum 0.5 mg a day at the beginning of STORAGE Acidum salicylicum 5 mg treatment, 2 to 3 mes a day Store below 25 °C. Gentamicini sulfas 2 mg aer 3 days. Then gentle massage Protect from light. Carbethopendecinii around the ear is recommended bromidum 0.125 mg so that the product can beer PACKAGE 15 ml. Ear drops, soluon. Colourless, penetrate the ssues. In case of slightly turbid soluon. neglected, crusted condions it is recommended to soen TARGET SPECIES the ssue ﬁrst and remove crusts Dogs, cats. with forceps. INDICATION Treatment usually lasts 5 to Os externa caused by 7 days, but maximally 12 days microorganisms sensive to the (3 days aer disappearance acve substances of the product. of clinical symptoms).

194 18 Dermatologics

The right mix of the three acve ingredients

OTIMIX ear drops suspension

COMPOSITION DOSAGE SHELF LIFE Composion – 1 ml: The drops administer into the ear 24 months. Miconazoli nitras 23 mg canal aer the cleaning with STORAGE Polymyxini B sulfas 5500 IU the cleaning soluon. The base Store below 25 °C. Prednisoloni acetas 5 mg of the ear massage carefully aer PACKAGE Ear drops, white suspension. administraon. Apply drops of the suspension 15 ml, 30 ml. TARGET SPECIES into the ear canal, repeat Dogs. administraon twice a day, in INDICATIONS the interval of the 12 hours. Os externa caused by The product apply 7 days. microorganisms sensive to the In case of the inﬂammatory signs acve substances of the product. connue in the management Gram posive microrganisms: the other 3–5 days. Staphylococcus spp. The way od the administraon: (parcularly S. intermedius, Topically into the ear canal. S. pseudointermedius a S. aureus including MRSA) Streptococcus spp. – hemolyc strains Gram negave microorganisms: Pseudomonas aeruginosa, E. coli, Enterococcus spp. Yeasts Malassezia pachydermas. The content of the corcosteroid prednisolon suitable improve inﬂammatory reacon.

195 18 Dermatologics

It dissolves cerumen and impuries and enables further treatment of possible os

OTIPUR ear drops soluon

The product for the gentle INDICATION SHELF LIFE cleaning of the external auditory The preparaon is intended for 18 months. canal of the dogs and cats. carefully cleaning of meatus STORAGE COMPOSITION acuscus externus in dogs and Store below 25 °C, the 1 gram of the drops contains: cats. It dissolves cerumen and preparaon should not be lacc acid 10.0 mg, impuries and enables further allowed to freeze! treatment of possible os. salicylic acid 1.2 mg, PACKAGE Carbethopendecinium DOSAGE 60 g, 200 g in a plasc bole bromide 5.0 mg, Apply a gentle pressure to the with dropper. Propylene glycol ad 1.0 g applicator and apply the TARGET SPECIES preparaon into the external Dog, cat. auditory canal. Soened crusts and surface cerumen should be removed with pliers in neglected cases. Massage carefully the aﬀected spots in order to release cerumen and remove it with a tampon unl acousc meatus is free.

196 18 Dermatologics

Herbal essenal oils soothe and promote healing

OTOFIN ear loon

COMPOSITION INDICATION Composion of the product in OTOFIN ear loon dissolves ear Fill in the external ear canal with 100 ml: wax, cleans the outer ear canal of the product and gently massage Propylene glycol 40.0 g; (±) - your dog or cat and leaves its flexible part. Allow the animal alpha-bisabolol 100 mg; fluid the skin supple and fragrant. to shake its head and wipe alcoholic calendula extract 3.0 g; Regular use helps keep the ears dissolved impuries running out lavender essenal oil 100 mg; clean and healthy. Calendula, of the ear with a coon swab. basil essenal oil 280 mg; lavender, basil, and propylene Repeat the procedure in case macrogol 7 glycerol cocoate; glycol are known for their ability of very dirty ears. acidifier; disodium edetate to reduce the numbers of SHELF LIFE dihydrate; foaming regulator; bacteria and yeasts, they also act 24 months. purified water. against some viruses and mites. Calendula and alpha-bisabolol STORAGE TARGET SPECIES Store below 25 °C. Dogs, cats. have a proven an-inflammatory and soothing effect. Protect from light and frost DOSAGE PACKAGE Roune use to maintain the ears 100 ml. healthy and clean: once a week In case of excessively dirty ears, the product can be applied once daily for 8 days, upon consultaon with a veterinarian.

197 18 Dermatologics

The most common indicaon for use of Pix-Fagi spray is hoof rot shot

PIX-FAGI Bioveta 200 mg/g cutaneous spray, soluon

COMPOSITION Treatment – psoriasis vulgaris, WITHDRAWAL PERIOD Composion in 1 g: lichen infected atopic dermas, Not intended for food-producing Acve substance lichen simplex chronicus, lichen animals. Fagi pix 200 mg planus, seborrhoeic dermas. SHELF LIFE Cutaneous spray, soluon Replacement of woven bandage; 2 years. Brown, slightly opalescent to an an-adhesive brown surface STORAGE cloudy liquid ﬁlm, which repels water, is made Store below 25 °C. Protect from TARGET SPECIES aer evaporaon of solvent. Tar light and radiant heat sources. Non-food warm-blooded animals, has favourable drying properes. The product is a Class 1 except felines. DOSAGE combusble! INDICATION Shake well before use.Apply by PACKAGE Diseases of the hoof and claw spraying from a distance 160 g – in hardened plasc HDPE where treatment with tar is of 15–20 cm, avoid useless vials of 250 ml with a mechanical indicated, hoof surgery, running down. When treang pump. treatment of hoof defects, claws and hooves it is preferable treatment following regular to create 2–3 layers (apply trimming of hoofs, fastening the following layer only aer of hoof dressings and covering the previous one has dried bandages. Dermatomycoses completely). in animals, especially in the early Using the product does not aﬀect stages or during sequenal the overall health of animals therapy, when the drying during pregnancy due to the properes of tar are manifested relavely small applicaon area favourably.

198 19 Ansera ANTISERA

CLOTEAN IMULYZIN POLYEQUAN 19 POLYGLOB 19 Ansera

High quality tetanus antoxin for prophylacc and therapeuc administraon

CLOTEAN inj. ad us. vet. Serum against tetanus

COMPOSITION DOSAGE STORAGE Acve substance: Subcutaneously, intramuscularly Store at a dark and dry place at Immunoserum tetanicum and intravenously. the temperature between 2 °C equinum navum Prophylacc and 8 °C. Keep out of the reach min. 300 IU/1 ml Large animals 4 000–6 000 IU and sight of children. INDICATION (13–20 ml) SHELF LIFE For passive immunizaon of Small animals 2 000–3 000 IU Shelf-life – 24 months, aer the animals during surgery, injuries, (7–10 ml) ﬁrst opening – 14 days. etc. The preparaon can be used Therapeuc Large animals 40 000 IU PACKAGE for therapeuc purposes at the 1 × 20 ml, 5 × 20 ml, 1 × 100 ml. onset of tetanus. (140 ml) Small animals 20 000 IU TARGET SPECIES (70 ml) Horse, cale, sheep, goat, pig, The therapeuc doses are dog, cat and, if necessary, other applied daily for 2–4 days and aﬀected animal species. then depending of the health condions of the treated animal.

200 19 Ansera

The product extends the passive protecon of the cale and increases the eﬀect of homologous anbodies

IMULYZIN suspension for injecon

COMPOSITION DOSAGE METHOD OF ADMINISTRATION 1 ml of the product contains : 1. Prevenve administraon: Subcutaneous or intramuscular Immunoglobulini bovini soluo Calves under 10 days 10–15 ml administraon. (as γ-globulins) min. 0.06 g Calves over 10 days 15–30 ml WITHDRAWAL PERIOD Lysinum (as 200 mg Lysini The minimum dose is 0.2 ml per None. hydrochloridum) 0.16 g 1 kg of body weight to each newly born individual as soon SHELF LIFE TARGET SPECIES Shelf-life 2 years and aer ﬁrst Cale. as possible aer birth or to each individual included in common opening 10 hours. INDICATIONS stabling, preferably before STORAGE 1. For protecve administraon collecon, or aer acceptance Store in a refrigerator against infecous diseases of the in the stable, preferably within (2 °C – 8 °C), respiratory tract and diarrhoeal 24 hours aer acceptance. It is protect from frost and light. diseases in calves, during the recommended to repeat the dose states of hypo and PACKAGE between days 10 and 20 aer the 100 ml in glass vial. agammaglobulinaemia, during ﬁrst administraon. various states of emergency and 2. Therapeuc administraon: general debilitaon. Calves under 10 days 15 ml 2. As part of comprehensive Calves over 10 days 25 ml treatments (supporve therapy). Other cale categories 30 ml The product is administered in For therapeuc use it is case of epidemic waves, or at recommended to repeat the dose crical mes of the year, or for 2–3 days later. The basic dose can regular treatment of each batch be increased in cases determined of calves according to the by a veterinary surgeon. situaon. Higher doses should be administered in divided porons applied to more sites. Immunity develops shortly aer administraon and lasts for 2–3 weeks.

201 19 Ansera

The content of anbodies against most common causes of neonatal infecon in foals

POLYEQUAN inj. ad us. vet. Serum against foal Sepc Polyarthris

COMPOSITION DOSAGE SHELF LIFE Composion – 100 ml: Prevenve 2 years, Acve substances Foals aged up to 1 week 25 ml aer ﬁrst opening – 10 hours. Immunoserum an Escherichia Foals aged 1 week STORAGE coli, Salmonella abortus equi, and above 50 ml Keep in a dry and dark place Streptococcus equi, Therapeuc at of 2 to 8 °C. Acnobacillus Double doses should be applied, equinum navum 100 ml half of it subcutaneously and the PACKAGE 50 ml, 100 ml. TARGET SPECIES rest intravenously. Foals. The applicaon can be repeated, if necessary. INDICATION Subcutaneous or intravenous Passive immunizaon of foals applicaon should be used. when breeding is endangered or in case of illness induced by E. coli, Salmonella abortus equi, Streptococcus equi, Acnobacillus equinum navum germs.

202 19 Ansera

Eﬀecve protecon of puppies against most common viral infecon

POLYGLOB soluon for injecon, for dogs

COMPOSITION DOSAGE SHELF LIFE Acve Substances: The prevenve dose is 0.4 ml per Shelf-life of the veterinary Immunoglobulinum contra 1 kg of body weight; it should be medicinal product as packaged Febris contagiosae applied repeatedly at the interval for sale 2 years, aer first canis min. 160 VNA50 of 48 hours. opening the immediate Immunoglobulinum The therapeuc dose is 0.4 ml packaging: 10 hours. contra Parvovirosis per 1 kg of body weight of the STORAGE canis min. 1024 HIU treated animal; it should be Store in a refrigerator Immunoglobulinum applied at 24-hour intervals unl (2 °C – 8 °C). contra Hepas contagiosae improvement of health, canis at Laryngotracheis but for 5 days as a maximum. PACKAGE 1 × 5 ml. canis min. 160 VNA50 Immunoglobulinum The product can be administered contra Parainfluensis intravenously and canis min. 64 HIU intramuscularly. TARGET SPECIES Intravenous administraon Dog. induces an immediate onset of passive immunity and provides INDICATIONS FOR USE, the highest degree of availability SPECIFYING THE TARGET of administered SPECIES immunoglobulins. Supporve therapy and passive immunoprophylaxis in dogs suffering from or being at risk of distemper, parvovirosis, hepas, laryngotracheis and parainfluenza. High levels of anbodies prevent the occurrence of these diseases or palliate their course.

203 204 20 Environmental disinfectants and inseccides ENVIRONMENTAL DISINFECTANTS AND INSECTICIDES

BIO KILL inseccidum IVASAN pets IVASAN farm 20 IVASAN spray 20 Environmental disinfectants and inseccides

The composion is odorless, harmless to humans and warm-blooded animals, eﬀecve against all known species of insects and developmental stages

BIO KILL inseccidum product for disinsecon

COMPOSITION a) Against cockroaches and PACKAGE Acve substance: Permethrine kitchen cockroaches – apply 100 ml, 200 ml, 450 ml – in white 2,5 g (0,25 %) in water emulsion. in form of strips in the cornes polyethylene bole with CHARACTERISTICS of the room, on door and mechanical spraying apparatus BIO KILL is a inseccidal spraying window casing, around lier 1000 ml, 5000 ml – in white preparaon with a long-term bins, washbasins, sewerage, polyethylene bollte with a top effect. It is determined for use distribuon of heat and hot STORAGE against insects in households, water At temperature of 10–40 °C. health service establishments, b) Against flies and mosquitos – apply on places where they SHELF LIFE food- processing plants, social 36 months. plants, social instuons, against usually seat, i.e. on window cockroaches, kitchen casing, ceiling, around droplight etc. Not intended to administraon cockroaches, flies, mosquitos, on skin or coat of domesc bed-bugs, fleas, moths, ants, c) Against fleas apply on the whole floor, carpet, resng place animals. wasps, silver fish, mites, vermins Toxic for cats, eliminate of food and fabrics of pets d) Against other species – the contact of cats with INSTRUCTIONS BEFORE apply direct to a place of their the inseccide. APPLICATION occurence. Shake before applicaon Apply the preparaon from distance of about 30 cm to all places where insects stay and shelter. The aended area should be evenly wet. The preparaon has no odour and it doesn´t keep visible traces. Repeat the spraying aer 3–4 weeks or in case of recurrence of insects.

206 20 Environmental disinfectants and inseccides

Long lasng, residual eﬀect – polymer layer reduces the possibility of pathogens adhesion

IVASAN pets

The concentrated liquid germs has not yet been reported. DILUTION OF WORKING disinfectant IVASAN Pets is used IVASAN Pets is intended not only SOLUTIONS to disinfect all washable surfaces for professional use, especially  Prevenve and connuous and medical equipment in for the needs of veterinary clinics disinfecon: 3% soluon veterinary clinics, veterinary (outpaent clinics, veterinary (0.3 litre/10 litres of water) hospital facilies and public hospitals, operang rooms,  spaces in which it prevents waing rooms) and laboratories, Focal and final infecons caused by viruses, but also for shelters, larger disinfecon: 5% soluon bacteria and fungi and prevents breeding facilies and (0.5 litre/10 litres of water) their spread. households. Do not wash the surface Treated surfaces (plasc, metal, Thanks to its safety, the product immediately aer treatment. wood, fabric, leather ...) do not is suitable for disinfecon The shortest exposure me is change their colour and of transport boxes, cages, 15 minutes. The water properes, their properes are terrariums, delivery pens, toilets temperature does not influence not disturbed, the product is and breeding tools (combs, toys, the product effect. The product noncorrosive and nonflammable. beds for pets, harnesses, can be used together with undersaddle pads…). convenonal detergents, but The product can be applied in INSTRUCTIONS FOR USE AND cannot be mixed with other the presence of people and disinfectants. animals, it does not irritate the DOSAGE skin and mucous membranes. The product may be applied with The me period needed for the a brush, mop, cloth, or fogging biocidal effect – at least ACTIVE SUBSTANCE machine, by spraying, washing, 15 minutes. alkyl(C12-16) dimethylbenzyl- or immersion. The product can STORAGE ammonium chlorides – be used for manual as well as 0.15 g/100 g Store at 10–25 °C. Do not expose mechanical disinfecon (WAP). the product to direct sunlight. Excipient: PHMG - It is not necessary to venlate SHELF LIFE polyhexamethylene guanidine rooms aer applicaon. Prepare 24 months. hydrochloride soluon from 30-50 ml of the The product has characterisc concentrate and 1 litre of water. PACKAGE long-lasng anbacterial (G+ and HDPE bole 1000 ml, G– bacteria, tuberculosis can 3000 ml. bacteria), anviral and anfungal effects. Existence of resistant

207 20 Environmental disinfectants and inseccides

Acve substances with anmicrobial acvity or the ability to inhibit the growth of microorganisms

IVASAN farm

Ivasan Farm is a liquid , water- has almost neutral pH, applicaon. Treated surfaces soluble product intended for is colourless and odourless, need not be washed professional disinfecon and which means the maximum subsequently. hygienic sanitaon of surfaces, environmental friendliness. DILUTION OF WORKING spaces and technological It does not damage disinfected SOLUTIONS equipment on animal farms and materials, does not change their  for disinfecon of vehicles used colour and is not corrosive. disinfecon at low load for animal transport and feed condions: 1% soluon  Disinfecon of livestock (0.1 litre/10 litres of water) stores. buildings (walls, floors, milking  ACTIVE SUBSTANCE equipment) fogging in the presence of alkyl(C12-16)dimethylbenzyl- animals: 2% soluon  Disinfecon of technological (0.2 litre/10 litres of water) ammonium chlorides – equipment (feeders, drinkers,  0.25 g/100 g. fencing of pens, air connuous prevenve Excipient: PHMG – condioning) disinfecon: 3% soluon polyhexamethylene guanidine (0.3 litre/10 litres of water)  Disinfecon of vehicles hydrochloride  intended for animal transport focal and final disinfecon: The product has characterisc 5% soluon + long-lasng anbacterial (G and  Disinfecon of hatcheries (0.5 litre/10 litres of water) G– bacteria, tuberculosis (walls, floors, incubators)  addive to water-based paints: bacteria), anviral and anfungal  Disinfecon connuous, focal 5% soluon effects. Existence of resistant and final (virucide, bactericide, (0.5 litre/10 litres of water) germs has not yet been reported. fungicide) Thanks to its unique properes, STORAGE INSTRUCTIONS FOR USE AND the product has a strong biocidal No special precauons are DOSAGE effect on viruses, bacteria and necessary. Store at 10–25 °C. IVASAN Farm can be used fungi, in full compliance with the Do not expose the product in fogging equipment forming fog current safety for humans, to direct sunlight. and thermal fog, in high-pressure animals and plants. apparatuses, by spraying, SHELF LIFE In recommended concentraons, washing objects and immersion 24 months. the product can be used in the soluon. The minimum PACKAGE in breeding facilies in the me period needed for the Can 5 l, can 10 l. presence of animals. IVASAN biocidal effect is 15 minutes aer Farm does not contain chlorine, 208 20 Environmental disinfectants and inseccides

No toxic components, contains no phenols, aldehydes or esters, colourless, odorless

IVASAN spray

The liquid disinfectant effecve off with water aer the Spray is also gentle to small against viruses, bacteria and fungi prescribed me of acon. mammals, birds and reples, is intended for direct spraying in ACTIVE SUBSTANCE so it can safely be used to veterinary and breeding facilies. alkyl(C12-16)dimethyl- disinfect their breeding facilies. The product does not contain benzylammonium Aer a short exposure wipe or chlorine, is nonflammable, chlorides – 0.025 g/100 g rinse the product of the treated colourless and odourless. Excipient: PHMG – surface, and the surface can It disinfects and removes odours polyhexamethylene guanidine come into immediate contact from invesgaon tables, hydrochloride. with an animal. transport boxes, beds for pets, The me period needed for pens, terrariums and breeding The product has characterisc the biocidal effect – at least long-lasng anbacterial (G+ and tools, including bowls. – 15 minutes. The IVASAN spray does not G bacteria, tuberculosis No probable direct and indirect damage any material and is bacteria), anviral and anfungal adverse side effects are known. therefore ideal for the effects. Existence of resistant germs has not yet been reported. STORAGE disinfecon of contaminated No special precauons are furniture, carpets, maresses and INSTRUCTIONS FOR USE AND necessary. Store at 10–25 °C. other materials from which it also DOSAGE Do not expose the product removes odour. Treated materials Spray on smelly and dirty places to direct sunlight. do not change their colour and and let it act for at least are not otherwise damaged. 15 minutes. It is not necessary SHELF LIFE Aer treatment, a thin polymer to wash or otherwise treat the 24 months. layer is formed on the surface, treated place aer applicaon. PACKAGE SIZE which eliminates biological In the event that your four-legged 500 ml. contaminaon (bacteria, viruses, friend fouled its crate or bed, it is moulds, fungi) on the treated good to apply the IVASAN Spray surface aer the prescribed and let it act for at least fieen exposure me. The layer protects minutes before washing. This up to several days and reduces method of applicaon ensures the risk of recontaminaon. a hundred percent cleanness The polymer layer can be rinsed without any odour. The IVASAN

209 210 21 Others

OTHERS

AQUA VIVA COFFEINUM BIOVETA 125 mg/ml JODOUTER 100 mg/ml LOTAGEN 360 mg/ml LOTAGEN injector PENBITAL 400 mg/ml 21 PROFYMAST emulsio 21 Others

Rehydraon water-soluble pulvis for peroral using in calves with basic pH

AQUA VIVA powder for oral soluon

COMPOSITION DOSAGE WITHDRAWAL PERIOD 1 bag 83,7 g contains: One bag represents one dose. None. Natrii citras anhydricus 3.92 g, The product is designed for SHELF LIFE Natrii acetas anhydricus 3.28 g, peroral administraon only. Shelf-life in an intact package: Natrii propionas 1.92 g, Prepare a fresh soluon by 24 months, up the prepared Kalii chloridum 2.98 g, mixing the contents of one bag soluon within 24 hours. Natrii chloridum 4.68 g, with 2 litres of water Kalii (about 30–37 °C). STORAGE dihydrogenophosphas 1.36 g, Store below 25 °C and keep in dry  at ﬁrst signs of diarrhea, stop place and protect for light. Flavum orangeatum feeding milk or milk substute Silica colloidalis anhydrica, and administer 2 litres of the PACKAGE Glucosum anhydricum dissolved 1 × 83,7 g in mul-layered PE/Al/ paper bag. TARGET SPECIES  formulaon 2× a day for 2 days Cale-calves. (4 feedings). INDICATIONS  then administer 1 litre of the The veterinary medicinal product formulaon mixed in 1 litre of reverses dehydraon and acidosis milk substute for 2 days and replaces lost electrolytes (4 feedings). in case of diarrhoea in calves  resulng from nutrious, then connue normal feeding. bacterial, viral or cryptosporidious eﬀects. If the diarrhea is lingering or obsnate and causes serious dehydraon, administer 2 litres of the soluon 3–4× a day. Do not administer the preparaon separately for a period longer than 4 days.

212 21 Others

Injecon product containing the central analepc – coﬀeine – intended for support of heart acon

COFFEINUM BIOVETA 125 mg/ml soluon for injecon

COMPOSITION DOSAGE WITHDRAWAL PERIOD 1 ml of injecon soluon Horse: 10–20 ml s.c., i.m. None. contains: Coffeinum (5–10 ml i.v.) SHELF LIFE anhydricum 125 mg. Cale: 20–40 ml s.c., i.m. Shelf-life 3 years, aer first TARGET SPECIES (10–20 ml i.v.) opening of the immediate Horses, cale, pigs, sheep, goats, Pig, sheep, goat: 2–8 ml. s.c., i.m. packaging: 28 days. dogs and cats. (1–4 ml i.v.) Dog: 0,5–2 ml s.c., i.m. STORAGE INDICATIONS (0,25–1 ml i.v.) Store at temperature Total acute physical weakness, Cat: 0, 5 ml s.c., i.m. (0,25 ml. i.v.) below 25 °C, protect from light collapse or shock as a and frost. manifestaon of depression or Oral doses may be administered in the same quanty as or a half PACKAGE paralysis of central nervous 50 ml in glass vial. system (aer exhausve exercise, higher than subcutaneous doses. poisoning or severe disease), Coffeine is administered surgical coma, heart insufficiency subcutaneously, intramuscularly (especially of bradycardial type) or intravenously. Aer s.c. and and other cases of injury or i.m. administraon the onset exhauson, depressive states, of effect is observed within to reduce the awakening 15–30 minutes and persists from general anaesthesia. for several hours. METHOD OF ADMINISTRATION Intramuscularly, subcutaneously,intravenously and orally.

213 21 Others

Local ansepc and disinfectant product containing ﬁxed iodine for treatment of inﬂammatory genitals diseases in cows and sows mainly

JODOUTER 100 mg/ml intrauterine soluon

COMPOSITION before inseminaon in case of 1st Pigs: 1 ml of soluon contains: degree endometris. Flush with 150 ml of product, Povidonum Cervicis, vaginis and vulvis – possibly more according to the iodinatum 100 mg (10%) treated either with a flush or by physiological volume of uterus. TARGET SPECIES applicaon of tampons, soaked Therapeuc flush must be Cale, pigs. with soluon (tampons are performed 12 hours aer labour. removed aer treatment). Sterility as a consequence INDICATIONS Urovaginis – clusters of urates of subacute infecon – Contaminaon of vagina with should be removed by massage administraon of 300 ml of the urine (urovagina), inflammaon and then should be administered product. of vagina and vaginal vesbulum 1 package (150 ml) into the Subsequent treatment could be (vaginis, vesbulis), cervix vagina, possibly to the performed with the same dose. (cervicis), acute and chronic intrauterine space. inflammaon of uterine mucosa WITHDRAWAL PERIOD Uterine atonia and pyometra – None. (endometris) caused by acute flush of uterus is performed, in and subacute infecons, infecon case greater quanty of soluon SHELF LIFE caused by trichomonas, vaginal is used, it is necessary to drain Shelf-life 18 months. injury, insufficient contraclity of the soluon from uterus. STORAGE uterus aer labour (atonia of Retenon of placenta – aer Store at the temperature below uterus aer labour), lochiometra, administraon develops 25 °C and protect from light. retenon of placenta (reteno contracon of uterus and secundarium), pyometra. PACKAGE bleeding stops, placenta is of The product is filled per 150 ml DOSAGE more rough consistence and it is in polyethylene compressible Cale: possible to treat it easily. containers. Endometris, trichomoniasis – Subsequent treatment could be Treatment of sterility must be performed with the same dose, it performed in metestrus or in is necessary to shake before use. diestrus. It is possible to recommend flushes 12 hours

214 21 Others

Local ansepc, disinfectant and adstringent product with very broad using in gynecology, obstetrics and surgery of many animals

LOTAGEN 360 mg/ml concentrate for vaginal/cutaneous soluon

COMPOSITION DOSAGE - in case of small surgical 1 ml of soluon contains: Cale intervenons, apply 20-% Policresulenum 360 mg Cervicis, vaginis and vulvis: aqueous soluon. TARGET SPECIES - irrigate the surface vaginal Use in small animals Cale, horses, pigs, sheep, goats, damages with 2% soluon. Eczema on lips and skin folds: dogs and cats. Addional lacteal glad: - apply gauze soaked with the - 9% soluon should be applied preparaon onto an affected INDICATIONS into a fistula using a milk spot. Sterility: cervicis, vaginis, catheter. Fistula of anal gland: vulvis, trichomoniasis. Mares - inject 2 ml of 5-% aqueous Obstetrics: vagina damage, post Vaginis (pneumovagina, soluon into an anal gland cavity. partum vaginal bleeding, urovagina): Repeat, if necessary. prevenon of MMA syndrome - irrigate with 1–2% soluon of Interdigital ulceraon: Surgical intervenons and the preparaon in order to - apply gauze soaked with the wound treatment: disturb parenchyma. preparaon on the affected spot slight local bleeding spots and - irrigaon of urovagina in horses between fingers. bleeding during surgical 1 – 3 litres of 0.5% soluon. Os externa inflammaon: intervenons, lupus (dermas Local use during surgical - rinse it with 5-% aqueous of fetlock in horses), hoof cancer intervenon and cleaning of old soluon of the preparaon once (pododermas chronica wounds a day. verrucosa madidans), ulcers on Hemostasis: extremies, interdigital WITHDRAWAL PERIOD - cover the wound with gauze None. necrobacillosis, foot-and-mouth soaked with the preparaon. disease in sheep, burns, Cleaning of wounds, ulcers, SHELF LIFE inflammaon of the alvearium abscesses, eczema and other Shelf-life aer first opening the (os externa), furunculosis, pathological dermal ganges: container: 21 days. dermal eczema, erosions, - apply gauze soaked with 4–20-% STORAGE irrigaon of urovagina in mares, soluon into the old wound or Store at the temperature to obliteraon of lacteal pseudo- the pathologically changed ssue. 25 °C. Do not refrigerate or fistula. Ulcers onto extremies, freeze. putrefacon of so ssue, PACKAGE interdigital necrobacillosis, etc.: 100 ml. 215 21 Others

Local ansepc, disinfectant and adstringent product for use in gynecology and obstetrics of cale and pigs

LOTAGEN injector intra-vaginal soluon

COMPOSITION TARGET SPECIES Pigs 150 ml of soluon contains: Cale, pigs. MMA syndrome: At least 300 ml Policresulenum 2.16 g INDICATIONS of the product is used for (Polycondensate of m-cresol- The product is intended for use in intravaginal irrigaon. sulfonic acid and formaldehyde gynaecology and obstetric where The therapeuc irrigaon shall be at the mass rao of 14:1) its anmicrobial, selecve, performed within 12 hours aer Selecve Coagulaon Effect: coagulaon and astringent effects delivery. Lotagen acts differenally onto can be advantageously used. WITHDRAWAL PERIOD the pathologically changed and Gynaecology – sterility induced None. healthy skin parts. Lotagen by acute infecons, cervicis, SHELF LIFE coagulates cells which funcon is vaginis, vulvis, genital Shelf-life 60 months. impaired; such cells are then trichomoniasis and urovaginis systemacally eliminated from STORAGE the organism (demarcaon, Obstetrics – vaginal injury, vaginal Store at the temperature eliminaon). On the other hand, bleeding between 15 °C – 25 °C. Lotagen smulates division of DOSAGE PACKAGE undamaged cells resulng in the Cale The product is filled per 150 ml formaon of the new mucosa Cervicis, vaginis and vulvis: in polyethylene compressible membrane; it means that cells Tampons soaked with the containers. are smulated to enhance skin product soluon are applied epithelizaon. (tampons shall be removed aer Astringent Effect: Lotagen treatment) or irrigaon is smulates contracon of smooth performed. musculature which results in arterioles contracon and thus small bleeding can be stopped.

216 21 Others

Gentle preparaon for euthanasia without adverse reacons

PENBITAL 400 mg/ml soluon for injecon

COMPOSITION WAY OF ADMINISTRATION WITHDRAWAL PERIOD Product contains pento- Intravenously or intracardially. Not intended for food-producing barbitalum natricum 400,0 mg The intravenous route of animals. (362,94 mg of pentobarbital) administraon should be the SHELF LIFE in one ml. route of choice and the velocity Shelf-life 36 months, aer first Injecon soluon. of administraon is necessary. opening the immediate Blue to sea – green soluon. Intravenous catheter is packaging 3 months. recommended in cale and TARGET SPECIES STORAGE Cale, goat, sheep, swine, horse horses. When intravenous administraon Store below 25 °C. and rabbit not intended for Protect from light. slaughter purposes. is difficult, the product may be Dog, cat, ferret. administered via the intracardiac PACKAGE route only aer deep sedaon or 100 ml. INDICATION anaesthesia. Euthanasia. DOSAGE The dose is uniform for all target species. Recommended dose of the pentobarbital is 140 mg/kg, equivalent to 0,35 ml/kg. Examinaon of the vital funcon is necessary aer administraon. The repeon of the administraon is necessary unl death confirmaon.

217 21 Others

Preparaon for external surface treatment of mammary gland

PROFYMAST emulsio Preparaon for surface treatment of mammary gland

COMPOSITION INDICATIONS STORAGE Composion of the product: Surface treatment of mammary Store below 25 °C, protect from Aqua puriﬁcata, Paraﬃnum gland. Soening the skin of the frost and direct sunlight. liquidum, Alcohol cetylicus, mammary gland (protecon PACKAGE Alcohol cetylstearylicus, against drying by sunlight on 250 ml with a pump, 1000 ml and Oleomacrogolum, Menthae pasture). 5000 ml in the plasc HDPE piperitae etheroleum – 0,5%, DOSAGE bole. Acidum stearicum, Dinatrii edetas Externally massage using on the dihydricus, Cera alba, mammary gland. Methylparabenum. Shake before use. TARGET SPECIES WITHDRAWAL PERIOD Cale-dairy cows (sheep, goat). None.

218 VETERINARY MEDICAMENTS PRODUCER

USEFUL CONTACTS Bioveta, a. s. Komenského 212 683 23 Ivanovice na Hané Czech Republic

Phone: +420 517 318 598, +420 517 318 500 www.bioveta.cz

Marek Vystavěl, Dipl. Ing. Markeng and Sales Director Phone: +420 517 318 599 E-mail: [email protected]

Věra Chlupová Head of Export Department Phone: +420 517 318 615 E-mail: [email protected]

Pavel Raška, D.V.M. Product Manager – Farm animals Mobil: +420 777 357 860 E-mail: [email protected]

Ladislav Křoustek, D.V.M. Product Manager – Companion animals Mobil: +420 775 854 707 E-mail: [email protected]

Wuhib Ayele, D.V.M., PhD. Product Manager – Companion animals and poultry Mobil: +420 775 894 441 E-mail: [email protected]

219 NOTES

220 Our producon is preparing these noveles for you:

BIOSUIS PRRS live lyophilisate and solvent for suspension for injecon

MLV vaccine for acve immunizaon of clinically healthy pigs in a PRRSV contaminated herds and farms (environment), to reduce viraemia caused by infecon with European strains of PRRS virus.

BIOSUIS Salm emulsion for injecon

For immunizaon of pregnant gilts and sows in order to induce colostral immunity, and beer protecon of suckling piglets against bacterial infecon by strains of Salmonella enterica subsp enterica, serovars Typhimurium, Infans and Derby.

RABADROP oral suspension

Vaccine for oral prophylacc immunisaon of wild red foxes and raccoon dogs against rabies with apathogenic rabies virus strain. Duraon of imunity at least 12 months. Store frozen at –20 °C and lower. The thawed vaccine bait may be stored for 90 days from 2 °C to 8 °C.