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CURRICULUM VITAE Ramón Bataller, M.D

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CURRICULUM VITAE Ramón Bataller, M.D CURRICULUM VITAE Ramón Bataller, M.D. Personal Data: Citizenship: Spain Business Address: 2209 McGavran-Greenberg University of North Carolina at Chapel Hill C.B. # 7461 Chapel Hill, NC 27599-7461 Languages: Catalan, Spanish, English, Italian Education: High School: Colegio Maristas, Valencia, Spain University of Valencia School of Medicine, Valencia, Spain, 1984-1990. Professional Experience: Resident, Liver and Gastroenterology Units, Hospital Clínic, Barcelona, 1991-1994. Faculty member, Emergency Room, Hospital Clínic, Barcelona, 1994-1998. Research Fellow, Liver Unit, Hospital Clínic, Barcelona, 1995-2000. Visiting Fellow, Università degli Studi di Firence, Florence, Italy, 1995. Visiting Fellow, Free University of Brussels, Brussels, Belgium, 1997. Postdoctoral Fellow, University of North Carolina at Chapel Hill, 2000-2003. Senior Especialist, Liver Unit, Hospital Clínic, Barcelona, 2003-2011 Associate Porfessor, UNC Chapel Hill, 2011-present Board Certified: Diplomate of Spanish Board of Gastroenterology, 1995. Societies: Member, Asociación Española para el Estudio del Hígado. Member, European Association for the Study of Liver Diseases (EASL). Member of the Scientific Committee, Governing Board, EASL (2009-2011) Member, International Society for Research of Hepatic Sinosoid (ISRHS) Editorial Board Gastroenterology (2007-2010) World Journal of Gastroenterology (2006-) Gut (Associate Editor 2008-2011) Gastroenterology Research and Practice (2009-) Research Interests: Pathogenesis and treatment of hepatic fibrosis. Alcohol-induced liver disease. Nonalcoholic steatohepatitis. PUBLICATIONS Original articles: 1.- Bataller Sifre R, Gómez García MA, Ferrandis Borrás S, Bataller R, Bataller Alberola RB y Alberola García MD. Replicación viral, daño histológico y movimiento enzimático en hepatopatías crónicas por virus B. Rev Esp Enf Digest 1989;6: 537-543. 2.- Bataller R, Llach J, Salmerón JM, Elizalde JI, Mas A, Piqué JM, Brullet E, Terés J, Bordas JM, Rodés J. Endoscopic sclerotherapy in upper gastrointestinal bleeding due to the Mallory- Weiss syndrome. Am J Gastroenterol 1994;89:112-116. 3.- Bataller Sifre R, Roselló Morera J, Bataller R, Ferrández Izquierdo A, Castillo Pallarés J, Bort Martí J, Galindo Puerto MJ. Correlación del cociente hígado/bazo isotópico con el daño hístico en hepatopatías crónicas difusas. Rev Esp Enf Digest 1994; 86:651-654. 4.- Elizalde JI, Llach J, Bordas JM, Bataller R, Mondelo F, Panés J, Terés J. Valor del control endoscópico tras escleroterapia por lesión péptica gastroduodenal. Gastroenterol Hepatol 1994;17:11-13. 5.- Nieto I, Llach J, Bordas JM, Mondelo F, Elizalde JI, Bataller R, Terés J. Hallazgos endoscópicos gastrointestinales en pacientes infectados por el virus de la inmunodeficiencia. Gastroenterol Hepatol 1995;18:57-60. 6.- Saló J, Ginès A, Anibarro L, Jiménez W, Bataller R, Clària J, Ginès P, Rivera F, Arroyo V, Rodés J. Effect of upright posture and physical exercise on endogenous neurohormonal 2 systems in cirrhotic patients with sodium retention and normal supine plasma renin, aldosterone and norepinephrine levels. Hepatology 1995;22:479-487. 7.- Saló J, Ginès A, Quer JC, Planas R, Ginès P, Bataller R, Jiménez W, Fernández- Esparrach G, Arroyo V, Rodés J. Renal and neurohormonal changes following simultaneous administration of systemic vasoconstrictors and renal vasodilators in patients with hepatorenal syndrome. J Hepatol 1996;25: 916-923. 8.- Saló J, Jiménez W, Kuhn M, Ginès A, Ginès P, Fernández-Esparrach G, Angeli P, Clària J, Bataller R, Arroyo V, Forssmann WG, Rodés J. Urinary excretion of urodilatin in patients with cirrhosis. Hepatology 1996;24:1428-1432. 9.- Saló J, Ginès A, Quer JC, Fernández-Esparrach G, Guevara M, Ginès P, Bataller R, Planas R, Jiménez W, Arroyo V, Rodés J. Renal and neurohormonal changes following simultaneous administration of systemic vasoconstrictors and dopamine or prostacyclin in cirrhotic patients with hepatorenal syndrome. J Hepatol 1996;25:916-923. 10.- Bordas JM, Elizalde I, Llach J, Mondelo F, Bataller R, Teres J. Biliary reflux due to sphincter of Oddi ablation: a new pathogenetic explanation for long-term major biliary symptoms after endoscopic-sphincterotomy. Endoscopy 1996;28:642-646 11.- Llovet JM, Rodriguez-Iglesias P, Moitinho E, Planas R, Bataller R, Navasa M, Menacho M, Pardo A, Castells A, Cabré E, Arroyo V, Gasull MA, Rodés J. Spontaneous bacterial peritonitis in cirrhotic patients undergoing selective intestinal decontamination. A retrospective study of 229 spontaneous bacterial peritonitis episodes. J Hepatol 1997; 26:88-95. 12.- Bataller R, Nicolás JM, Ginès P, Esteve A, Görbig MN, García-Ramallo E, Pinzani M, Jiménez W, Ros J, Jiménez W, Thomas A, Arroyo V, Rodés J. Arginine vasopressin induces contraction and stimulates growth in cultured human hepatic stellate cells. Gastroenterology 1997;113:615-624. 13.- Saló J, Guevara M, Fernández-Esparrach G, Bataller R, Ginès A, Jiménez W, Ginès P, Rivera F, Arroyo V, Rodés J. Impairment of renal function during moderate physical exercise in cirrhotic patients with ascites. Relationship with the activity of neurohormonal systems. Hepatology 1997;25:1338-1342. 3 14.- Saló J, Ginès A, Ginès P, Piera C, Jiménez W, Guevara M, Fernández-Esparrach G, Sort P, Bataller R, Arroyo V, Rodés J. Effect of therapeutic paracentesis on plasma volume and transvascular escape rate of albumin in patients with cirrhosis. J Hepatol 1997;27:645-653. 15.- Guevara M, Ginès P, Jiménez W, Sort P, Fernández-Esparrach G, Escorsell A, Bataller R, Bosch J, Arroyo V, Rivera F, Rodés J. Increased adrenomedullin levels in cirrhosis: relationship with hemodynamic abnormalities and vasoconstrictor systems. Gastroenterology 1998;114:336-343. 16.- Guevera M, Bru C, Ginès P, Fernández-Esparrach G, Sort P, Bataller R, Jiménez W, Arroyo V, Rodés J. Increased cerebral resistance in cirrhosis: relationship with renin- angiotensin and central nervous systems. Hepatology 1998;28:39-44. 17.- Bataller-Sifre R, Bataller R. Aclaramiento de ácido glicocólico en la Enfermedad de Gilbert. An Med Intern 1998;15:580-583. 18.- Bataller R, Nicolás JM, Ginès P, Görbig MN, García-Ramallo E, Tobías E, Pinzani M, Lario S, Thomas AT, Arroyo V, Rodés J. Contraction of cultured human stellate cells activated in culture: a role for voltage-operated calcium channels. J Hepatol 1998; 29:398-408. 19.- Görbig MN, Ginès P, Bataller R, Nicolás JM, Garcia-Ramallo E, Clària J, Arroyo V, Rodés J. Atrial natriuretic factor inhibits endothelin-induced calcium increase and cell contraction in human cultured hepatic stellate cells. Hepatology 1999;30:501-509. 20.- Bataller R, Ginès P, Nicolás JM, Görbig MN, Garcia-Ramallo E, Bosch J, Arroyo V, Rodés J. Angiotensin II induces contraction and proliferation of human hepatic stellate cells. Gastroenterology 2000;118:1149-1156. 21.- Titos E, Clària J, Bataller R, Bosch-Mercé M, Ginès P, Jiménez W, Arroyo V, Rivera F, Rodés J. Mechanisms of increased hepatic cysteinyl-leukotriene production in experimental cirrhosis. Gastroenterology 2000;119:794-805. 22.- Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón JM, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J. Terlipressin plus albumin infusion: an effective and safe therapy for hepatorenal syndromeHepatorenal syndrome. J Hepatol 2000; 33:43-48. 4 23.- Llovet JM, Moitinho E, Sala M, Bataller R, Rodriguez-Iglesias P, Castells A, Fernandez J, Planas R, Navasa M, Bruix J, Rodes J. Prevalence and prognostic value of hepatocellular carcinoma in patients presenting with spontaneous bacterial peritonitis. J Hepatol 2000; 33:423-429. 24.- Nicolás JM, Fernández-Solà J, Fatjó R, Casamitjana R, Bataller R, Sacanella E, Tobías E, Badía E, Estruch R. Increased circulating leptin levels in chronic alcoholism. Alcohol Clin Exp Res 2001; 25:83-88. 25.- Fernández-Esparrach G, Sánchez-Fueyo A, Ginès P, Uriz J, Quinto L, Ventura PJ, Cardenas A, Guevara M, Sort P, Jiménez W, Bataller R, Arroyo V, Rodés J. A prognostic model for predicting survival in cirrhosis with ascites. J Hepatol 2001;34:46-52. 26.- Görbig MN, Ginès P, Bataller R, Nicolás JM, García-Ramallo E, Cejudo P, Sancho-Bru P, Jiménez W, Arroyo V, Rodés J. Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility. J Hepatol 2001; 34:222-229. 27.- Bataller R, Gasull X, Ginès P, Hellemans K, Görbig MN, Nicolás JM, Sancho-Bru P, De las Heras D, Gual A, Geerts A, Arroyo V, Rodés J. In vitro and in vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage-operated calcium channels. Hepatology 2001; 33:956-962. 28.- Gasull X, Bataller R, Ginès P, Sancho-Bru P, Nicolás JM, Görbig MN, Ferrer E, Badía E, Gual A, Arroyo V, Rodés J. Human myofibroblastic hepatic stellate cells express Ca2+- activated K+ channels that modulate the effects of endothelin-1 and nitric oxide. J Hepatol 2001;35:739-748. 29.- Uriz J, Gines P, Ortega R, Jimenez W, Cardenas A, Calahorra B, Sort P, Fernandez J, Bataller R, Arroyo V, Rivera F, Rodes J. Increased plasma levels of neuropeptide Y in hepatorenal syndrome. J Hepatol 2002;36:349-55. 30.- Ortega R, Ginès P, Uriz J, Cárdenas A, Calahorra B, De Las Heras D, Guevara M, Bataller R, Jiménez W, Arroyo V, Rodés J. Terlipressin therapy with and without albumin for patients with hepatorenal syndrome: Results of a prospective, nonrandomized study. Hepatology 2002;36:941-948. 5 31.- Paik YH, Schwabe R, Bataller R, Russo MP, Jobin C, Brenner DA. Toll-like receptor 4 mediates inflammatory effects by bacterial lipopolysaccharide in activated human hepatic stellate cells. Hepatology 2003;37:1043-1055. 32.- Bataller R, Ginès P, Sancho-Bru P, Lora JM, Al-Garawi A, Solé M, Nicolás JM, Jiménez JM, Weich N, Gutierrez-Ramos JC, Arroyo V, Rodés J. Activated human hepatic stellate cells express the components of the renin-angiotensin system and synthesize angiotensin II. Gastroenterology 2003;125:117-125. 33.- De las Heras D, Fernandez J, Gines P, Cardenas A, Ortega R, Navasa M, Barbera JA, Calahorra B, Guevara M, Bataller R, Jimenez W, Arroyo V, Rodes J. Increased carbon monoxide production in patients with cirrhosis with and without spontaneous bacterial peritonitis.
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