BMC Genetics BioMed Central Research article Open Access Haplotype frequencies at the DRD2 locus in populations of the East European Plain Olga V Flegontova*1, Andrey V Khrunin1, OlgaILylova1, Larisa A Tarskaia1, Victor A Spitsyn2, Alexey I Mikulich3 and Svetlana A Limborska1 Address: 1Department of Human Molecular Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia, 2Medical and Genetics Scientific Centre, Russian Academy of Medical Sciences, Moscow, Russia and 3Institute of Arts, Ethnography and Folklore, National Academy of Sciences of Belarus, Minsk, Belarus Email: Olga V Flegontova* -
[email protected]; Andrey V Khrunin -
[email protected]; Olga I Lylova -
[email protected]; Larisa A Tarskaia -
[email protected]; Victor A Spitsyn -
[email protected]; Alexey I Mikulich -
[email protected]; Svetlana A Limborska -
[email protected] * Corresponding author Published: 30 September 2009 Received: 9 March 2009 Accepted: 30 September 2009 BMC Genetics 2009, 10:62 doi:10.1186/1471-2156-10-62 This article is available from: http://www.biomedcentral.com/1471-2156/10/62 © 2009 Flegontova et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: It was demonstrated previously that the three-locus RFLP haplotype, TaqI B-TaqI D-TaqI A (B-D-A), at the DRD2 locus constitutes a powerful genetic marker and probably reflects the most ancient dispersal of anatomically modern humans. Results: We investigated TaqI B, BclI, MboI, TaqI D, and TaqI A RFLPs in 17 contemporary populations of the East European Plain and Siberia.