At a glance Br J Ophthalmol: first published as 10.1136/bjophthalmol-2020-318090 on 26 October 2020. Downloaded from Highlights from this issue

doi:10.1136/bjophthalmol-2020-318090 Keith Barton , James Chodosh , Jost B Jonas , Editors in chief

Glaucoma in the Northern Ireland Cohort The effect of partial posterior vitreous Comparison of OCT angiography in for the Longitudinal Study of Ageing detachment on spectral-domain optical children with a history of intravitreal (NICOLA): cohort profile, prevalence, coherence tomography retinal nerve fibre injection of ranibizumab vs laser awareness and associations (seepage1492) layer thickness measurements photocoagulation for retinopathy of The crude prevalence of glaucoma in (seepage1524) prematurity (see page 1556) Northern Ireland of 2.83% (95% CI Among glaucoma suspects, eyes with par- In this cross-sectional study, we found that 2.31%, 3.46%) is comparable to other tial posterior vitreous detachments, com- the central foveal vessel length density and European population-based studies. pared to eyes without, were associated perfusion density, the foveal avascular Approximately two thirds of people with with greater average, superior, and inferior zone area and central foveal thicknesses glaucoma were undiagnosed. Associations retinal nerve fibre layer thickness of children who had undergone different with glaucoma were consistent with cur- measurements. treatments, might vary. rent understanding of the disease. Three-year follow-up of choroidal Comparison of central visual sensitivity Selective laser trabeculoplasty vs neovascularisation in eyes of chronic between monocular and binocular testing medication for open-angle glaucoma: central serous chorioretinopathy in advanced glaucoma patients using imo systematic review and meta-analysis of (see page 1561) perimetry (see page 1528) randomised clinical trials (see page 1500) After an average of 3 years of follow, most In glaucomatous eyes, better-eye central Selective laser trabeculoplasty is a safe and patients remained clinically stable without sensitivity was better and worse-eye cen- effective IOP-lowering therapy for open- the persistence of subretinal fluid despite tral sensitivity was poorer, under binocular angle glaucoma. The patients received significant structural changes in choroidal than monocular conditions. Monocular selective laser trabeculoplasty need signifi- neovascularisation on optical coherence visual-field measurements should be care- cant lower number of medications. tomography angiography. fully considered when assessing advanced Anterior chamber particles are associated glaucoma patients. Comparison of various surgical with reduction of intraocular pressure techniques for optic disc pit after selective laser trabeculoplasty (see The effect of low dose atropine on myopia maculopathy: vitrectomy with internal page 1508) progression, pupil diameter and limiting membrane (ILM) peeling alone The number of the anterior chamber par- accommodative amplitude—low dose vs inverted ILM flap ‘plug’ vs ticles evaluated with anterior segment atropine and myopia progression autologous scleral ‘plug’ (see page 1567) optical coherence tomography immedi- (see page 1535) Resolution of maculopathy in cases of ately after selective laser trabeculoplasty

In a one-year study, the myopia progres- optic disc pits is swifter if the pit is plugged http://bjo.bmj.com/ correlates significantly with intraocular sion effects of low dose atropine were dose using either an inverted internal limiting pressure reduction at least for 3 months dependent however the side effect profile membrane flap or scleral flap, compared after the procedure. was independent of dosage. to vitrectomy alone. Efficacy and safety evaluation of ORCA study: Real-world vs reading centre benzalkonium chloride preserved Objectively measured near work, outdoor assessment of disease activity of eye-drops compared with alternatively exposure and myopia in children

neovascular age-related macular on September 25, 2021 by guest. Protected copyright. preserved and preservative-free eye-drops (see page 1542) degeneration (nAMD) (see page 1573) in the treatment of glaucoma: a systematic According to the objective data, the time Lack of treatment despite correct identifi- review and meta-analysis (see page 1512) spent with a light intensity of >3000 lux cation of CNV activity was detected in the This systematic review, based on 16 rando- was a protective factor against myopia, ORCA study. Not only can misinterpreta- mised clinical trials, could not determine while the time spent with a working distance tion of SD-OCT lead to vision loss over significant differences in efficacy or safety of <20 cm was a risk factor for myopia. between benzalkonium chloride-preserved time, but also lack of treatment despite prostaglandin analogue and beta-blocker correct interpretation. eye drops compared to alternatively pre- Long-term (20-year) real-world outcomes served or preservative-free eye drops. of intravenous chemotherapy Comparison of true-colour wide-field (chemoreduction) for retinoblastoma in confocal scanner imaging with standard First-in-human continuous 24-h 964 eyes of 554 patients at a single centre fundus photography for diabetic measurement of intraocular pressure and (see page 1548) retinopathy screening (see page 1579) ocular pulsation using a novel contact lens A 20-year analysis of 964 eyes with retino- Vision-threatening diabetic retinopathy sensor (see page 1519) blastoma treated with intravenous che- features which are missed with standard A first-in-man study is reported using con- motherapy revealed tumour control fundus cameras, can be detected with the tact lens that measures intraocular pressure (avoidance of enucleation and external true-colour, wide-field EIDON confocal and ocular pulsation in mm Hg. This novel beam radiotherapy) for Groups A, B, and scanner. Clinically relevant differences in device is also able to detect physiological Cat≥91%, D at 71%, and E at 32% grading result in more referrals for sight- and induced intraocular pressure variations. (p<0.001). threatening disease when using the EIDON.

Br J Ophthalmol November 2020 Vol 104 No 11 i At a glance Br J Ophthalmol: first published as 10.1136/bjophthalmol-2020-318090 on 26 October 2020. Downloaded from

Effectiveness of an innovative and Visual and refractive outcomes and Microsporidial stromal keratitis: comprehensive eye care model for complications in femtosecond laser-assisted characterisation of clinical features, individuals in residential care facilities: vs conventional phacoemulsification cataract ultrastructural study by electron surgery: findings from a randomised, results of the residential ocular care microscopy, and efficacy of different surgical (ROC) multicentred randomised controlled clinical trial (see page 1596) Post-operative refractive and visual out- modalities (see page 1613) controlled trial (see page 1585) The current study highlights that medi- In this randomised controlled trial, we comeswerecomparablebetweenfemtose- cond laser-assisted cataract surgery and cal therapy is ineffective for microspor- showed that an integrated eye assessment conventional phacoemulsification surgery. idal stromal keratitis and surgical and intervention programme improved Complication rates were low in both groups. intervention is a requisite to prevent near vision, emotional well-being and per- the extensive spread of mature spores ceived vision quality in the short-term for Long-term visual outcomes of the boston type i keratoprosthesis in canada in the corneal stroma; however, surgical visually impaired residential care dwellers (see page 1601) therapy was associated with overall poor in Australia. A retrospective cohort study of consecutive outcome. Boston type I keratoprosthesis procedures Observation of nine previously reported showed 61.8% of eyes maintained better and ten unreported SLC4A11 mutations Normative patterns and factors associated than preoperative visual acuity 7 years post- among 20 Iranian CHED probands and with presbyopia progression in operatively; the main risk factor for irrever- sible vision loss was preoperative glaucoma. identification of an MPDS mutation as a multiethnic Asian population: the possible cause of CHED and FECD in one Singapore Epidemiology of Eye Diseases Three-year follow-up of accelerated transepithelial corneal cross-linking for family (see page 1621) Study (see page 1591) Screening of SLC4A11 in CHED patients We found that the overall near addition progressive paediatric keratoconus (see page 1608) and exome sequencing revealed unre- power in Asians was lower than current Keratometry and corneal thickness remained ported mutations and identification of recommended guidelines. Additionally, stable after accelerated transepithelial cor- MPDZ which, similarly to SLC4A11, Malays demonstrated the highest rate of neal cross-linking (ATE-CXL) for the pae- affects membrane transport and is presbyopia progression in comparison to diatric progressive keratoconus patients a possible cause of CHED and FECD in Chinese and Indians. during the 36-month follow-up period. one family. http://bjo.bmj.com/ on September 25, 2021 by guest. Protected copyright.

ii Br J Ophthalmol November 2020 Vol 104 No 11