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SENS-Research-Foundation-2019
by the year 2050, cardiovascular an estimated 25-30 the american 85 percent of adults disease years and older age 85 or older remains the most population will suffer from common cause of 2 1 2 dementia. death in older adults. triple. THE CLOCK IS TICKING. By 2030, annual direct The estimated cost of medical costs associated dementia worldwide was 62% of Americans with cardiovascular $818 billion diseases in the united over age 65 have in 2015 and is states are expected to more than one expected to grow to rise to more than chronic condition.1 3 $2 trillion $818 billion. by 2030.1 References: (1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732407/, (2) https://www.who.int/ageing/publications/global_health.pdf, (3) https://www.cdcfoundation.org/pr/2015/heart-disease-and-stroke-cost-america-nearly-1-billion-day-medical-costs-lost-productivity sens research foundation board of directors Barbara Logan Kevin Perrott Bill Liao Chairperson Treasurer Secretary Michael Boocher Kevin Dewalt James O’Neill Jonathan Cain Michael Kope Frank Schuler 02 CONTENTS 2019 Annual Report 04 Letter From The CEO 06 Outreach & Fundraising 08 Finances 09 Donors erin ashford photography 14 Education 26 Investments 20 Conferences & Events 30 Research Advisory Board 23 Speaking Engagements 31 10 Years Of Research 24 Alliance 32 MitoSENS 34 LysoSENS 35 Extramural Research 38 Publications 39 Ways to Donate cover Photo (c) Mikhail Leonov - stock.adobe.com special 10th anniversary edition 03 FROM THE CEO It’s early 2009, and it’s very late at night. Aubrey, Jeff, Sarah, Kevin, and Mike are sitting around a large table covered in papers and half-empty food containers. -
5 EVENTS in ONE: Head Real World Evidence and Big Data Solutions Novartis, Switzerland
FIFTH ANNUAL - LIFE SCIENCE R&D DATA INTELLIGENCE LEADERS FORUM Basel, Switzerland January 23-24th, 2018 Optional Workshop 22nd, January Hear keynote presentations from the experts: Etzard Stolte Global Head Knowledge Management Roche, Switzerland Abhimanyu Verma 5 EVENTS IN ONE: Head Real World Evidence and Big Data Solutions Novartis, Switzerland Day 1: Torsten Niederdraenk Head of Technology Center Strategic Developments in R&D Big Siemens Healthcare, Germany Data Catherine Brownstein Scientific Director Day 2 (am): Stream 1 Manton Center for Orphan Disease Research Boston Children’s Hospital, USA Discovery & Omics Data Excellence Navin Ramachandran Radiology Consultant Day 2 (am): Stream 2 University College London Hospitals NHS Foundation Trust, Healthcare specialist in distributed ledgers and IoT Clinical & Patient Level Data IOTA Foundation, UK Excellence Marie-Claire Peakman Executive Director, Head Hit Discovery & Lead Profiling, Medicine Design Day 2 (pm): Stream A Pfizer, USA R&D IT & Bioinformatics Alex Zhavoronkov Co-founder, Insilico Medicine, CSO Day 2 (pm): Stream B The Biogerontology Research Foundation, UK Ivana Schnur Digital Health Collaborations Co-founder, CMO Sense.ly, USA Pre-Event Workshop: Jan 22nd Paul Wicks Artificial Intelligence for Drug Vice President of Innovation PatientsLikeMe, UK Discovery: Workshop for Senior Jazz Panchoo Global Strategy Head, VP, Digital Platforms Executives Ascensia Diabetes Care, Switzerland This Event is Certified for Continuing Professional Development with more than 30 presentations -
Read Our New Annual Report
The seeds of a concept. The roots of an idea. The potential of a world free of age-related disease. Photo: Sherry Loeser Photography SENS Research Foundation Board of Directors Barbara Logan, Chair Bill Liao, Secretary Kevin Perrott, Treasurer Michael Boocher Jonathan Cain Kevin Dewalt Michael Kope Jim O’Neill Frank Schüler Sherry Loeser Photography 2 Contents CEO Letter (Jim O’Neill) 4 Finances 5 Donors 6 - 7 Fundraising & Conferences 8 - 9 Around the World with Aubrey de Grey 10 Outreach 11 Founding CEO Tribute & Underdog Pharmaceuticals 12 - 13 Investments 14 Welcome New Team Members 15 Education 16 - 17 Publications & Research Advisory Board 18 Research Summaries 19 - 22 Ways to Donate 23 The SRF Team Front row: Anne Corwin (Engineer/Editor), Amutha Boominathan (MitoSENS Group Lead), Alexandra Stolzing (VP of Research), Aubrey de Grey (Chief Science Officer), Jim O’Neill (CEO), Bhavna Dixit (Research Associate). Center row: Caitlin Lewis (Research Associate), Lisa Fabiny-Kiser (VP of Operations), Gary Abramson (Graphics), Maria Entraigues-Abramson (Global Outreach Coordinator), Jessica Lubke (Administrative Assistant). Back row: Tesfahun Dessale Admasu (Research Fellow), Amit Sharma (ImmunoSENS Group Lead), Michael Rae (Science Writer), Kelly Protzman (Executive Assistant). Not Pictured: Greg Chin (Director, SRF Education), Ben Zealley (Website/Research Assistant/ Deputy Editor) Photo: Sherry Loeser Photography, 2019 3 From the CEO At our 2013 conference at Queens College, Cambridge, I closed my talk by saying, “We should not rest until we make aging an absurdity.” We are now in a very different place. After a lot of patient explanation, publication of scientific results, conferences, and time, our community persuaded enough scientists of the feasibility of the damage repair approach to move SENS and SENS Research Foundation from the fringes of scientific respectability to the vanguard of a mainstream community of scientists developing medical therapies to tackle human aging. -
How to Think and Act Rationally
1 How to Be Rational: How to Think and Act Rationally David Robert [email protected] Abstract: This paper is divided into 4 sections. In Sections 1 and 2, I address (1) how to acquire rational belief attitudes and (2) how to make rational choices. Building on Sections 1 and 2, I then answer two of the most pressing questions of our time: (3) Should you be skeptical of climate change? (4) Should you invest in life-extension medical research? It has always appalled me that really bright scientists almost all work in the most competitive fields, the ones in which they are making the least difference. In other words, if they were hit by a truck, the same discovery would be made by somebody else about 10 minutes later. —Aubrey de Grey To make rational choices involves choosing courses of action that best serve one’s ends. As a good example, one’s chances of having a positive impact on the world are significantly greater if one focuses one’s efforts on solving the world’s biggest, most urgent problems than if one focuses one’s efforts on solving comparatively small, non-urgent problems that will not ultimately matter in the long run if the biggest, most urgent problems are left unsolved. Therefore, if one’s goal is to make a difference in the world, then it is simply not rational to focus one’s efforts on solving comparatively small, non-urgent problems. It is true that functioning societies do need people working on comparatively small day- to-day problems. -
321444 1 En Bookbackmatter 533..564
Index 1 Abdominal aortic aneurysm, 123 10,000 Year Clock, 126 Abraham, 55, 92, 122 127.0.0.1, 100 Abrahamic religion, 53, 71, 73 Abundance, 483 2 Academy award, 80, 94 2001: A Space Odyssey, 154, 493 Academy of Philadelphia, 30 2004 Vital Progress Summit, 482 Accelerated Math, 385 2008 U.S. Presidential Election, 257 Access point, 306 2011 Egyptian revolution, 35 ACE. See artificial conversational entity 2011 State of the Union Address, 4 Acquired immune deficiency syndrome, 135, 2012 Black Hat security conference, 27 156 2012 U.S. Presidential Election, 257 Acxiom, 244 2014 Lok Sabha election, 256 Adam, 57, 121, 122 2016 Google I/O, 13, 155 Adams, Douglas, 95, 169 2016 State of the Union, 28 Adam Smith Institute, 493 2045 Initiative, 167 ADD. See Attention-Deficit Disorder 24 (TV Series), 66 Ad extension, 230 2M Companies, 118 Ad group, 219 Adiabatic quantum optimization, 170 3 Adichie, Chimamanda Ngozi, 21 3D bioprinting, 152 Adobe, 30 3M Cloud Library, 327 Adonis, 84 Adultery, 85, 89 4 Advanced Research Projects Agency Network, 401K, 57 38 42, 169 Advice to a Young Tradesman, 128 42-line Bible, 169 Adwaita, 131 AdWords campaign, 214 6 Affordable Care Act, 140 68th Street School, 358 Afghan Peace Volunteers, 22 Africa, 20 9 AGI. See Artificial General Intelligence 9/11 terrorist attacks, 69 Aging, 153 Aging disease, 118 A Aging process, 131 Aalborg University, 89 Agora (film), 65 Aaron Diamond AIDS Research Center, 135 Agriculture, 402 AbbVie, 118 Ahmad, Wasil, 66 ABC 20/20, 79 AI. See artificial intelligence © Springer Science+Business Media New York 2016 533 N. -
SENS Research Foundation Annual Report 2015
S E N S R e s e a r c h F o u n d a t i o n has a unique mission: to ensure the development of cures which repair the underlying cellular and molecular damage of aging. This document, our 2 0 1 5 R e p o r t, demonstrates our commitment to delivering on the promise of that mission, and to meeting the challenges facing the rapidly emerging rejuvenation biotechnology field. Our research program delivers key proof-of-concept results. Our education program prepares the first generation of rejuvenation biotechnology professionals. Our outreach program widens and connects our communi. Our Rejuvenation Biotechnology conferences unite stakeholders from academic, industrial, political, regulatory and financial institutions. Together, we are transforming the way the world researches and treats age-related disease. i n t r o d u c t i o n 2 l e t t e r f r o m t h e C E O 3 c o m m u n i t y 4 o u t r e a c h 6 e d u c a t i o n 8 r e s e a r c h 1 0 f i n a n c e s 1 4 r e s e a r c h : p r o j e c t b y p r o j e c t 1 5 s u p p o r t i n g t h e f o u n d a t i o n 2 3 FOUNDATION BOARD OF LEADERSHIP DIRECTORS Mike Kope Barbara Logan Jonathan Cain Chief Executive Officer Board Chair Kevin Dewalt Kevin Perrott Dr. -
SENS Research Foundation Annual Report 2014
sens research foundation foundation report august 2014 mission 2 leer from the CEO 3 outreach 4 research 8 education 14 finances 16 research: project by project 18 FOUNDATION BOARD OF LEADERSHIP DIRECTORS Mike Kope Barbara Logan Jonathan Cain Chief Executive Officer Board Chair Kevin Dewalt Kevin Perrott Aubrey de Grey Treasurer James O’Neill Chief Science Officer Bill Liao Mike Kope Secretary © 2014, SENS Research Foundation a: 110 Pioneer Way, Suite J / Mountain View, CA 94041 / USA p: 650.336.1780 f: 650.336.1781 www.sens.org All rights reserved. No part of this material may be reproduced without specific permission from SENS Research Foundation. SENS Research Foundation’s federal employer ID number is 94-3473864. Because SENS Research Foundation is a 501(c)(3) non-profit, your donation may be tax deductible. transforming the way the world researches and treats age-related disease We fund research at institutions around the world, and at our own Moun- tain View facility. Our research is integrated with wide-ranging outreach and education programs. Our goal is to see the emergence of an industry that will cure the diseases of aging, an industry based around what we call rejuvenation biotechnology. Many things go wrong with aging bodies, but at the root of them all is the burden of decades of unrepaired damage to the cellular and molecular structures that make up the functional units of our tissues. Faced with the diseases and disabilities caused by this damage, today’s medicine is too often reduced to crisis management in the emergency room, painfully harsh treatments for diseases such as cancer, or best efforts at palliative care. -
Return of Organization Exempt from Income Tax OMB No
Extended to November 15, 2018 Return of Organization Exempt From Income Tax OMB No. 1545-0047 Form 990 Under section 501(c), 527, or 4947(a)(1) of the Internal Revenue Code (except private foundations) 2017 Department of the Treasury | Do not enter social security numbers on this form as it may be made public. Open to Public Internal Revenue Service | Go to www.irs.gov/Form990 for instructions and the latest information. Inspection A For the 2017 calendar year, or tax year beginning and ending B Check if C Name of organization D Employer identification number applicable: Address change SENS Foundation Inc. Name change Doing business as Sens Research Foundation, Inc. 94-3473864 Initial return Number and street (or P.O. box if mail is not delivered to street address) Room/suite E Telephone number Final return/ 110 Pioneer Way J (650) 336-1780 termin- ated City or town, state or province, country, and ZIP or foreign postal code G Gross receipts $ 8,057,919. Amended return Mountain View, CA 94041 H(a) Is this a group return Applica- tion F Name and address of principal officer: Michael Kope for subordinates? ~~ Yes X No pending same as C above H(b) Are all subordinates included? Yes No I Tax-exempt status: X 501(c)(3) 501(c) ( )§ (insert no.) 4947(a)(1) or 527 If "No," attach a list. (see instructions) J Website: | WWW.SENS.ORG H(c) Group exemption number | K Form of organization: X Corporation Trust Association Other | L Year of formation: 2009 M State of legal domicile: CA Part I Summary 1 Briefly describe the organization's mission or most significant activities: Develop, promote and ensure widespread access to rejuvenation biotechnologies. -
Scientific Programme Monday, 09 September 2019 09:00
Scientific Programme Monday, 09 September 2019 [BC]2 Session , University of Basel Seminarraum 106 09:00 - 16:00 T1: Using the Ensembl REST APIs to programmatically access genomic data Room Seminarraum 106 Overview The Ensembl project provides a comprehensive and integrated source of annotation of genome sequences, including genes, genetic variation, features that regulate gene expression, homologues and alignments. These data are accessible programmatically in a language agnostic manner via the Ensembl REST APIs. Scripting against public databases like Ensembl facilitates quick retrieval of valuable data in your preferred format or can be integrated into pipelines for data analysis. This tutorial is aimed at researchers and developers interested in exploring Ensembl beyond the website. The workshop covers how to use the Ensembl REST APIs, including understanding the major endpoints and how to write scripts to call them. Feedback from previous courses •“Wish I had taken the course long time ago. Didn’t know before how good and powerful APIs are!” API workshop, EMBL-EBI, January 2016 •“I really enjoyed the course, and the ENSEMBL API will become a very relevant part of my toolset.” API workshop, Cambridge, December 2013 Audience and requirements The tutorial is aimed at bioinformatics and wet-lab researchers who use genomic data and would like to use scripting to access these data directly, including integrating into pipelines. This is a hands-on training course and participants will need to bring a laptop with WiFi enabled in order to take part. Participants must be able to code in Python, Perl or R. The training will utilise Jupyter Notebooks hosted by Microsoft Azure – to use these all participants will need to have a free Microsoft Account. -
Hormonal Rejuvenation Course Aubrey De Grey-A Roadmap To
Hormonal Rejuvenation Course Aubrey de Grey-A Roadmap To End Aging F. Karl Weddige Panama College of Cell Science In partial fulfillment of the requirements of course 616 August 25, 2014 HORMONAL REJUVENATION – 2015 ASSIGNMENT #1 STUDENT: KARL WEDDIGE Essay Questions (1) Please re-read the Syllabus and watch the video featuring Aubrey de Grey which is found there. Please write a brief report giving your impressions of the content and also of Aubrey de Grey: What is his main premise? How good are his facts…meaning, is he convincing? What do you conclude from viewing this video? Has the video made you think differently about aging? What do you make of this video?? Note: We are just having some fun as an introduction to the course…not looking for a scientific paper here. Aubrey de Grey is not an unintelligent man - In fact, some might suggest that he is a deep thinking genius while others criticize his scientific prowess. De Grey is a Biomedical Gerontologist who holds a PhD in Biology from Cambridge University, was a computer scientist prior to receiving his PhD, and is the founder of multiple scientific foundations (SENS Research Foundation, Methuselah Foundation). The lyrics of the song “Forever Young” by the musical group Alphaville are purely indicative of Aubrey de Greys premise behind his research: “A Roadmap to End Aging”. …Some are like water, some are like the heat Some are a melody and some are the beat Sooner or later they all will be gone Why don't they stay young? It's so hard to get old without a cause I don't want to perish like a fading horse Youth's like diamonds in the sun, And diamonds are forever So many adventures given up today, So many songs we forgot to play. -
Longevity-Conference
Top-30 Longevity Conferences 2019-2020 Table of Contents Introduction 3 Infographic Mind Map 4 List of Top-30 Longevity Conferences in 2019 - 2020 5 Top-30 Longevity Conferences 2019-2020: Distribution by Country 7 Top-30 Longevity Conferences 2019-2020: Distribution by Region 8 Top-30 Longevity Conferences 2019-2020: Distribution by Main Topic 9 Top-30 Longevity Conferences 2019-2020: Fees 10 Top-30 Longevity Conferences 2019-2020: Location 11 Influential Past Conferences That Have Established Longevity as a Prominent Mainstream Topic 17 150 Longevity Conferences 2019-2020 24 Appendix I. Top-30 Longevity Conferences 2019-2020 Profiles 28 Disclaimer 60 Introduction 3 With the rapid development of the Longevity industry, the number of events dedicated to this topic has increased proportionately. These events differ in a number of ways including target audience, central topics being covered, entrance fee range, location, venue, etc. Potential participants need to be aware of such conferences details while planning which conferences to attend. This report aims to serve as a guide in this type of decision making, which also includes a cost-benefit analysis of the conferences themselves. The report presents the Top-30 conferences related to Longevity, providing key facts and figures on each. The Top-30 conferences chosen for this list, from 150 Longevity-themed conferences in total, satisfy the following criteria: ● They are well attended, with a large number of speakers as well as participants ● They include at least one panel on the topic of Longevity ● They feature speakers who are professionals in the industry As a number of conferences for 2020 have not yet been announced, we expect to be updating the report regularly, increasing both the number of the conferences covered and the quantity of information on them. -
Aging Intervention Foundation
Organizations and Longevity Funds Advancing Aging Interventions in Humans Following Their Progress Johnny Adams https://www.AgingInterventionFoundation.org [email protected] (949) 922-9786 (US) https://www.AgingIntervention Foundation.org/OrganizationsFollowProgress.pdf Last updated July 4, 2021 Often updated. You may not have the current version. Check frequently for updates. Disclaimer: I do not know many of the people involved with these companies. I do not necessarily endorse many of them. This is just a list provided as a service. Please contact me with information on organizations you know of that are making advances in aging interventions in humans. Aging Intervention Foundation https://www.AgingInterventionFoundation.org https://www.aginginterventionfoundation.org/AgingInterventionProgram.pdf Some references, lists, directories http://whoswho.senescence.info/companies.php http://agingbiotech.info/companies/ https://docs.google.com/spreadsheets/d/1mnR3uA2pBoT0aUegmoo5yVcLDad0ESlWrXl9_pXv Dsg/edit#gid=0 https://www.aginganalytics.com/ https://mindmaps.dka.global/ https://www.aginganalytics.com/top-30-longevity-conferences https://www.fightaging.org/archives/2020/01/notes-on-the-sens-research-foundation-pitch-day- january-2020/ https://www.researchgate.net/publication/315836059_Longevity_Organizational_Report https://www.scribd.com/document/371542878/Longevity-Organizational-Report-4-3-17 List of Longevity Clinical Trials as of Sept 2019 - List starts in the 8th paragraph. https://www.worldhealth.net/news/current-state-longevity-clinical-trials Age Reversal Network https://www.age-reversal.net Turn Biotechnologies www.turn.bio An informed member of our community commented: I foresee using the Oisín treatment for clearing away the senescent cell junk, followed by the Turn treatment for reprogramming the remaining aging cells to a younger state as the realistic path to achieving the real rejuvenation of aging humans (like me).