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Biogerontology: a Novel Tool to Stay Healthy in Old Age
MoPAct Policy Brief: 5 Biogerontology: a novel tool to stay healthy in old age Policy priority Healthy lifestyle interventions in particular regarding nutrition and vaccination need to be implemented early in life with a lifecourse perspective. Summary: Key findings: • Accumulating evidence from experimental studies shows that aging is not inevitably linked with the development of chronic diseases. • Only 20-25% of healthy life expectancy (HLE) is predetermined by genes; lifestyle and environment play a major role. • Age-associated accumulation of molecular and cellular damage can be prevented or greatly delayed by lifestyle interventions e.g. dietary manipulations. • Classical strategies (e.g. nutrition, exercise, vaccination) require broad communication to public. • Novel strategies (e.g. dietary interventions, novel drugs, stem cells) need successful translation from the understanding of molecular mechanism to animal models to clinic. • To be successful interventions need to be started early Figure 1. Strategies to increase HLE. (1) Classical interventions include nutrition, exercise, vaccination, no smoking/alcohol/drugs. (2) Novel interventions include in life with a life-course perspective. dietary interventions, clearance of senescent and damaged cells, mitohormetics, stem cells, drugs against inflammation, rejuvenation factors from blood, telomeres, Background: epigenetic drugs, chaperons and proteolytic systems (novel interventions adapted from López-Otín et al., Cell 2013). Population aging is progressing fast in all developed countries. Aging is associated with the development of multiple serious chronic illnesses, including type 2 diabetes, hypertension, heart Prevention disease, stroke, cancer, cognitive impairment and increased Prevention prior to the development of age-associated diseases morbidity and mortality from infectious diseases. As people is key for successful aging. -
Who Wants to Live Forever? Reader’S Digest
HEALTH Who Wantsto Live Forever? As a species, we humans appear to be the undisputed masters of our planet. Moreover, since Yuri Gagarin’s inaugural space flight in 1961, we can even leave the confines of Earth to travel in space. Yet, we have one Achilles’ heel—we’re mortal BY CHRIS MENON 1234567890 1234567890 36 BRAIN LIGHT/ALAMY STOCK PHOTO WHO WANTS TO LIVE FOREVER? READEr’s DIGEST T 122 YEARS, THE MAXIMUM HUMAN LIFESPAN lags well behind some species of giant tortoise (188 years), Greenland shark (400 years) and the record set by the lowly Icelandic clam (507 years). Even those relatively few humans who do manage to make it past 100—some 14,570 people in the UK in 2015—are invariably bedeviled byA poor health. Recently, efforts to extend the healthy of Amazon, has similarly invested human lifespan have achieved much in Unity Biotechnology, which aims publicity following the backing of “to design therapeutics that prevent, visionary, super-rich Silicon Valley halt, or reverse diseases of ageing”. tech entrepreneurs. In 2013, Google’s Unity intends to develop a new founders created a subsidiary class of therapies called “senolytic company called Calico (short for medicines”, designed to selectively the California Life Company), eliminate senescent cells. Senescent Billionaire researchers, which promptly hired a team of top cells accumulate with age and, Some believe that death, Arthur Levinson, Jeff technologies that scientists and now has more than unlike normal cells, they secrete like any disease, can be Bezos and Elon Musk the SENS Research £1bn in the bank to fund its work. -
From Here to Immortality: Anti-Aging Medicine
FromFrom HereHere toto Immortality:Immortaalitty: AAnti-AgingAnnntti-AAgging MMedicineedicine Anti-aging medicine is a $5 billion industry. Despite its critics, researchers are discovering that inter ventions designed to turn back time may prove to be more science than fiction. By Trudie Mitschang 14 BioSupply Trends Quarterly • October 2013 he symptoms are disturbing. Weight gain, muscle Shifting Attitudes Fuel a Booming Industry aches, fatigue and joint stiffness. Some experience The notion that aging requires treatment is based on a belief Thear ing loss and diminished eyesight. In time, both that becoming old is both undesirable and unattractive. In the memory and libido will lapse, while sagging skin and inconti - last several decades, aging has become synonymous with nence may also become problematic. It is a malady that begins dete rioration, while youth is increasingly revered and in one’s late 40 s, and currently 100 percent of baby boomers admired. Anti-aging medicine is a relatively new but thriving suffer from it. No one is immune and left untreated ; it always field driven by a baby- boomer generation fighting to preserve leads to death. A frightening new disease, virus or plague? No , its “forever young” façade. According to the market research it’s simply a fact of life , and it’s called aging. firm Global Industry Analysts, the boomer-fueled consumer The mythical fountain of youth has long been the subject of base will push the U.S. market for anti-aging products from folklore, and although it is both natural and inevitable, human about $80 billion now to more than $114 billion by 2015. -
SENS-Research-Foundation-2019
by the year 2050, cardiovascular an estimated 25-30 the american 85 percent of adults disease years and older age 85 or older remains the most population will suffer from common cause of 2 1 2 dementia. death in older adults. triple. THE CLOCK IS TICKING. By 2030, annual direct The estimated cost of medical costs associated dementia worldwide was 62% of Americans with cardiovascular $818 billion diseases in the united over age 65 have in 2015 and is states are expected to more than one expected to grow to rise to more than chronic condition.1 3 $2 trillion $818 billion. by 2030.1 References: (1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732407/, (2) https://www.who.int/ageing/publications/global_health.pdf, (3) https://www.cdcfoundation.org/pr/2015/heart-disease-and-stroke-cost-america-nearly-1-billion-day-medical-costs-lost-productivity sens research foundation board of directors Barbara Logan Kevin Perrott Bill Liao Chairperson Treasurer Secretary Michael Boocher Kevin Dewalt James O’Neill Jonathan Cain Michael Kope Frank Schuler 02 CONTENTS 2019 Annual Report 04 Letter From The CEO 06 Outreach & Fundraising 08 Finances 09 Donors erin ashford photography 14 Education 26 Investments 20 Conferences & Events 30 Research Advisory Board 23 Speaking Engagements 31 10 Years Of Research 24 Alliance 32 MitoSENS 34 LysoSENS 35 Extramural Research 38 Publications 39 Ways to Donate cover Photo (c) Mikhail Leonov - stock.adobe.com special 10th anniversary edition 03 FROM THE CEO It’s early 2009, and it’s very late at night. Aubrey, Jeff, Sarah, Kevin, and Mike are sitting around a large table covered in papers and half-empty food containers. -
Shared Ageing Research Models (Sharm): a New Facility to Support Ageing Research
Biogerontology (2013) 14:789–794 DOI 10.1007/s10522-013-9457-0 METHOD Shared Ageing Research Models (ShARM): a new facility to support ageing research Adele L. Duran • Paul Potter • Sara Wells • Tom Kirkwood • Thomas von Zglinicki • Anne McArdle • Cheryl Scudamore • Qing-Jun Meng • Gerald de Haan • Anne Corcoran • Ilaria Bellantuono Received: 5 July 2013 / Accepted: 16 August 2013 / Published online: 2 October 2013 Ó The Author(s) 2013. This article is published with open access at Springerlink.com Abstract In order to manage the rise in life expec- Wellcome Trust, open to all investigators. It collects, tancy and the concomitant increased occurrence of stores and distributes flash frozen tissues from aged age-related diseases, research into ageing has become murine models through its biorepository and provides a strategic priority. Mouse models are commonly a database of live ageing mouse colonies available in utilised as they share high homology with humans and the UK and abroad. It also has an online environment show many similar signs and diseases of ageing. (MICEspace) for collation and analysis of data from However, the time and cost needed to rear aged communal models and discussion boards on subjects cohorts can limit research opportunities. Sharing of such as the welfare of ageing animals and common resources can provide an ethically and economically endpoints for intervention studies. Since launching in superior framework to overcome some of these issues July 2012, thanks to the generosity of researchers in but requires dedicated infrastructure. Shared Ageing UK and Europe, ShARM has collected more than Research Models (ShARM) (www.ShARMUK.org) 2,500 tissues and has in excess of 2,000 mice regis- is a new, not-for-profit organisation funded by tered in live ageing colonies. -
5 EVENTS in ONE: Head Real World Evidence and Big Data Solutions Novartis, Switzerland
FIFTH ANNUAL - LIFE SCIENCE R&D DATA INTELLIGENCE LEADERS FORUM Basel, Switzerland January 23-24th, 2018 Optional Workshop 22nd, January Hear keynote presentations from the experts: Etzard Stolte Global Head Knowledge Management Roche, Switzerland Abhimanyu Verma 5 EVENTS IN ONE: Head Real World Evidence and Big Data Solutions Novartis, Switzerland Day 1: Torsten Niederdraenk Head of Technology Center Strategic Developments in R&D Big Siemens Healthcare, Germany Data Catherine Brownstein Scientific Director Day 2 (am): Stream 1 Manton Center for Orphan Disease Research Boston Children’s Hospital, USA Discovery & Omics Data Excellence Navin Ramachandran Radiology Consultant Day 2 (am): Stream 2 University College London Hospitals NHS Foundation Trust, Healthcare specialist in distributed ledgers and IoT Clinical & Patient Level Data IOTA Foundation, UK Excellence Marie-Claire Peakman Executive Director, Head Hit Discovery & Lead Profiling, Medicine Design Day 2 (pm): Stream A Pfizer, USA R&D IT & Bioinformatics Alex Zhavoronkov Co-founder, Insilico Medicine, CSO Day 2 (pm): Stream B The Biogerontology Research Foundation, UK Ivana Schnur Digital Health Collaborations Co-founder, CMO Sense.ly, USA Pre-Event Workshop: Jan 22nd Paul Wicks Artificial Intelligence for Drug Vice President of Innovation PatientsLikeMe, UK Discovery: Workshop for Senior Jazz Panchoo Global Strategy Head, VP, Digital Platforms Executives Ascensia Diabetes Care, Switzerland This Event is Certified for Continuing Professional Development with more than 30 presentations -
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Article Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis Graphical abstract Authors Christopher D. Wiley, Rishi Sharma, Sonnet S. Davis, ..., Marco Demaria, Arvind Ramanathan, Judith Campisi Correspondence [email protected] (C.D.W.), [email protected] (A.R.), [email protected] (J.C.) In brief Senolytics, transgenic, and pharmacological interventions that selectively kill senescent cells are currently in clinical trials aiming to treat age-related degenerative pathologies. Here, Wiley et al. discover that senescent cells produce multiple signaling lipids known as oxylipins. One oxylipin, dihomo-15d-PGJ2, promotes features of senescence by activating RAS and is released from cells during senolysis, serving as the first biomarker of the Highlights process in culture and in vivo. d Senescent cells make several oxylipins, dihomo- prostaglandins, and leukotrienes d Dihomo-15d-PGJ2 is intracellular during senescence and released during senolysis d Dihomo-15d-PGJ2 activates RAS, promoting senescence and the SASP d Positive feedback between prostaglandins, RAS, and p53 maintains senescence Wiley et al., 2021, Cell Metabolism 33, 1–13 June 1, 2021 ª 2021 Published by Elsevier Inc. https://doi.org/10.1016/j.cmet.2021.03.008 ll Please cite this article in press as: Wiley et al., Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis, Cell Metabolism (2021), https://doi.org/10.1016/j.cmet.2021.03.008 ll Article Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis Christopher D. Wiley,1,2,* Rishi Sharma,1 Sonnet S. Davis,1 Jose Alberto Lopez-Dominguez,1 Kylie P. Mitchell,1 Samantha Wiley,1 Fatouma Alimirah,1 Dong Eun Kim,1 Therese Payne,1 Andrew Rosko,1 Eliezer Aimontche,1 Sharvari M. -
Read Our New Annual Report
The seeds of a concept. The roots of an idea. The potential of a world free of age-related disease. Photo: Sherry Loeser Photography SENS Research Foundation Board of Directors Barbara Logan, Chair Bill Liao, Secretary Kevin Perrott, Treasurer Michael Boocher Jonathan Cain Kevin Dewalt Michael Kope Jim O’Neill Frank Schüler Sherry Loeser Photography 2 Contents CEO Letter (Jim O’Neill) 4 Finances 5 Donors 6 - 7 Fundraising & Conferences 8 - 9 Around the World with Aubrey de Grey 10 Outreach 11 Founding CEO Tribute & Underdog Pharmaceuticals 12 - 13 Investments 14 Welcome New Team Members 15 Education 16 - 17 Publications & Research Advisory Board 18 Research Summaries 19 - 22 Ways to Donate 23 The SRF Team Front row: Anne Corwin (Engineer/Editor), Amutha Boominathan (MitoSENS Group Lead), Alexandra Stolzing (VP of Research), Aubrey de Grey (Chief Science Officer), Jim O’Neill (CEO), Bhavna Dixit (Research Associate). Center row: Caitlin Lewis (Research Associate), Lisa Fabiny-Kiser (VP of Operations), Gary Abramson (Graphics), Maria Entraigues-Abramson (Global Outreach Coordinator), Jessica Lubke (Administrative Assistant). Back row: Tesfahun Dessale Admasu (Research Fellow), Amit Sharma (ImmunoSENS Group Lead), Michael Rae (Science Writer), Kelly Protzman (Executive Assistant). Not Pictured: Greg Chin (Director, SRF Education), Ben Zealley (Website/Research Assistant/ Deputy Editor) Photo: Sherry Loeser Photography, 2019 3 From the CEO At our 2013 conference at Queens College, Cambridge, I closed my talk by saying, “We should not rest until we make aging an absurdity.” We are now in a very different place. After a lot of patient explanation, publication of scientific results, conferences, and time, our community persuaded enough scientists of the feasibility of the damage repair approach to move SENS and SENS Research Foundation from the fringes of scientific respectability to the vanguard of a mainstream community of scientists developing medical therapies to tackle human aging. -
Longevity and Generosity. the Death of Death. July 2018. N° 112
Longevity and generosity. The death of death. July 2018. N° 112. Some people say, “Oh, you shouldn’t do enhancement” but the thing is we do enhancement all the time — to some extent, all aging reversal is enhancement. Vaccines are enhancement… I think I’m just now getting up to speed after 63 years of education. Aging reversal is something that will buy me and many of my colleagues a lot more time to make many more contributions, so you might consider that a meta-level contribution, if we can pull that off. World-renowned Harvard University biology researcher George Church (source). Theme of the month. How to contribute financially to research for a much longer healthy life Introduction If you have considerable financial means you can afford medical care more easily than less well-off citizens. But whether you are rich or not, with a good "genetic capital" or not, whatever your precautions and your anti-aging clinic visits, in the current state of knowledge your chances are low of living more than 100 years if you are a woman and beyond 95 years if you are of the weaker sex for longevity. And whatever happens, you will not live past 122 years for a woman et 116 years for a man. To go further will require complex and costly research. If informed citizens pay money to support this research, it will be positive in a direct way by funding the research. It will also be positive in that it will show the growing interest in these issues. What could you do about it? Moderate financial support If your financial means are limited or if you do not wish to make large donations, your action can still have an impact. -
HCB 524 — Transhumanism
HCB 524 Special Topic in Bioethics Fall Semester, 2019. Tuesdays 6-8:30pm. Instructor of Record: Adam Sepe, MA, MLS(ASCP)cm [email protected] Course Description: Transhumanism and [Human?] Dignity. Throughout human history — and prehistory for that matter — technological advancement has drastically altered every aspect of human life. Most of us will say that many advents — such as cooking and the wheel — have been largely, if not entirely, beneficial. Would we say the same of all technology? Surely each of us can list technologies that have, in the very least, some considerable downsides. So while history and experience can tell us that some technologies are beneficial and that some other technologies are harmful, how can we know what kind of impact future technology will have? For now we can’t, and so all we can do is try, to the best of our ability, to imagine such futures and develop our technology with these considerations in mind. ‘Transhumanism’ refers a diverse collection of ideas that have one at least thing in common: through future technology, humanity will be fundamentally altered to an unprecedented degree. Some even believe there will come a time when, through our own action, the word ‘human’ will be obsolete; that we will be succeeded by entities (or an entity) for which ‘human’ does not apply. Most people who identify as transhumanists are, to varying degrees, proponents of such technology. They are in favor of such alterations and they argue that these will be beneficial. In this course, we will take a critical look at transhumanist claims. -
Syllabus 2018
FINAL DRAFT Summer One Semester 2018 HCB 504 BIOTECHNOLOGY: Special Topics Room 067 Mondays, Tuesday, Thursdays 6 – 8:30 pm Instructor of Record: Migdal, Kobba, Post Phyllis Migdal, MD MA [email protected] Timothy Kobba MA [email protected] Stephen Post PhD [email protected] Course Description: Dignity and Biomedical Aspirations – Therapy, Enhancement & Transhumanism The three “supers” of transhumanism are not just “science fiction.” Super-longevity, super-happiness, and super-intelligence, along with perfect babies, are works-in-progress at the interface of “old” evolved human nature as we have known it and technical progress toward the posthuman of our own creation. With the astonishing biotechnological powers that are increasingly reshaping nature and human nature, are we in a “transitional state” (transhumanism) en route to a redesigned posthuman future in which current limitations are overcome? Four centuries ago, Francis Bacon announced the biological utopia of the future in his The New Atlantis, replete with fountains of youth and chimeras. The term “transhumanism” was originally coined by the British biologist philosopher Julian Huxley in a 1957 essay to capture the ways in which social institutions could supplant evolution in refining and improving the species, as could technology. Sensory perception, emotive ability, cognitive capacity, health and life spans could all be augmented. The term was taken over in the 1990s by British philosopher Max More, who began defining the principles -
How to Think and Act Rationally
1 How to Be Rational: How to Think and Act Rationally David Robert [email protected] Abstract: This paper is divided into 4 sections. In Sections 1 and 2, I address (1) how to acquire rational belief attitudes and (2) how to make rational choices. Building on Sections 1 and 2, I then answer two of the most pressing questions of our time: (3) Should you be skeptical of climate change? (4) Should you invest in life-extension medical research? It has always appalled me that really bright scientists almost all work in the most competitive fields, the ones in which they are making the least difference. In other words, if they were hit by a truck, the same discovery would be made by somebody else about 10 minutes later. —Aubrey de Grey To make rational choices involves choosing courses of action that best serve one’s ends. As a good example, one’s chances of having a positive impact on the world are significantly greater if one focuses one’s efforts on solving the world’s biggest, most urgent problems than if one focuses one’s efforts on solving comparatively small, non-urgent problems that will not ultimately matter in the long run if the biggest, most urgent problems are left unsolved. Therefore, if one’s goal is to make a difference in the world, then it is simply not rational to focus one’s efforts on solving comparatively small, non-urgent problems. It is true that functioning societies do need people working on comparatively small day- to-day problems.