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Guide Des Aides Pour Les Jeunes De L'yonne
GUIDE DES AIDES POUR LES JEUNES DE L’YONNE SEXUALITÉ - CONTRACEPTION - VIE AFFECTIVE AIDER - PRÉVENIR - ACCOMPAGNER LES POINTS D’INFORMATION JEUNESSE LES MISSIONS LOCALES DE L’YONNE SPORT ET JEUNESSE AU CONSEIL DÉPARTEMENTAL ASSOCIATION PRÉVENTION ROUTIÈRE 16-25 ANS SEXUALITÉ - CONTRACEPTION - VIE AFFECTIVE ACCUEIL GRATUIT CENTRE DE PLANIFICATION DU CONSEIL DÉPARTEMENTAL ET CONFIDENTIEL Lieux d’écoute et d’information gratuits, les Centres de planification et d’éducation familiale sont ouverts à tous, en toute confidentialité. Consultations médicales, conjugales et familiales : sur rendez-vous. AUXERRE TOUCY SENS Conseil Départemental de l’Yonne Conseil Départemental de l’Yonne Centre hospitalier Unité Territoriale de Solidarité Unité Territoriale de Solidarité 1 avenue Pierre de Coubertin-89100 Sens 4 avenue de Perrigny-89000 Auxerre 10 rue Arrault-89130 Toucy Tél : 03 86 86 19 88 Tél : 03 86 49 59 00 Tél : 03 86 44 42 02 AVALLON MIGENNES Conseil Départemental de l’Yonne Centre P.M.I Unité Territoriale de Solidarité 29 avenue des Cosmonautes-89000 Migennes 2 rue du Général Leclerc-89200 Avallon Tél : 03 86 72 74 05 / 06 86 48 07 69 Tél : 03 86 34 95 35 TONNERRE JOIGNY Conseil Départemental de l’Yonne Centre hospitalier Unité Territoriale de Solidarité 5 avenue Gambetta-89300 Joigny 35 rue Vaucorbe-89700 Tonnerre Tél : 03 86 72 74 03 / 06 86 48 07 69 Tél : 03 86 54 85 04 CeGIDD = CENTRES GRATUITS D’INFORMATION, DE DÉPISTAGE ET DE DIAGNOSTIC. Ces centres offrent la possibilité de faire un test de dépistage (sida,hépatites b et c, infections sexuellement transmissibles) et d’obtenir des informations et de la documentation. -
Chapter 6: Old People Are People Too, So Let's Act
Career Planning & Adult Development JOURNAL Volume 31, Number 2 ISSN 0736-1920 Summer 2015 OUR FUTURE: Projections of Work and Life Helen Harkness, Guest Editor QThe Future Q The End of Work as We Know It QJobs and Careers on the Front Line of the Future QSilicon Valley and the New Rules of Work Q Training Challenges Facing Education and Training and Career Development in the Future QOld people are people too, so let’s act accordingly Q Crisis of Human Capital in Aerospace: It’s All About the STEM QCollege for All – Reality or Flawed Myth? QOur Jobs: The American Workforce and Economy in Crisis Q The Future Has Arrived: The Future is Now the Present Summer 2015..............................Career Planning and Adult Development JOURNAL..............................1 CAREER PLANNING and ADULT DEVELOPMENT JOURNAL Volume 31, Number 2 ISSN 0736-1920 Summer 2015 OUR FUTURE: Projections of Work and Life Looking Ahead with the Journal,E\Steven E. Beasley, Managing Editor4 Introduction to this Issue, E\ Helen Harkness, PhD, Guest Editor5 Chapter 1: 7KH)XWXUHE\ Leigh Ellen Key8 Chapter 2: 7KH(QGRI:RUNDV:H.QRZ,Wby Andy Hines10 Chapter 3: -REVDQG&DUHHUVRQWKH)URQW/LQHRIWKH)XWXUHby Gary Marx20 Chapter 4: 6LOLFRQ9DOOH\DQGWKH1HZ5XOHVRI:RUNE\Gary A. Bolles28 Chapter 5: 7UDLQLQJ&KDOOHQJHV)DFLQJ(GXFDWLRQDQG7UDLQLQJ DQG&DUHHU'HYHORSPHQWLQWKH)XWXUHE\Timothy C. Mack40 Chapter 6: 2OGSHRSOHDUHSHRSOHWRRVROHW·VDFWDFFRUGLQJO\by Aubrey de Grey47 Chapter 7: &ULVLVRI+XPDQ&DSLWDOLQ$HURVSDFH,W·V$OO$ERXWWKH67(0 by Deborah Westphal51 Chapter 8: &ROOHJHIRU$OO²5HDOLW\RU)ODZHG0\WK"E\ -
Mixing Old and Young: Enhancing Rejuvenation and Accelerating Aging
Mixing old and young: enhancing rejuvenation and accelerating aging Ashley Lau, … , James L. Kirkland, Stefan G. Tullius J Clin Invest. 2019;129(1):4-11. https://doi.org/10.1172/JCI123946. Review Donor age and recipient age are factors that influence transplantation outcomes. Aside from age-associated differences in intrinsic graft function and alloimmune responses, the ability of young and old cells to exert either rejuvenating or aging effects extrinsically may also apply to the transplantation of hematopoietic stem cells or solid organ transplants. While the potential for rejuvenation mediated by the transfer of youthful cells is currently being explored for therapeutic applications, aspects that relate to accelerating aging are no less clinically significant. Those effects may be particularly relevant in transplantation with an age discrepancy between donor and recipient. Here, we review recent advances in understanding the mechanisms by which young and old cells modify their environments to promote rejuvenation- or aging-associated phenotypes. We discuss their relevance to clinical transplantation and highlight potential opportunities for therapeutic intervention. Find the latest version: https://jci.me/123946/pdf REVIEW The Journal of Clinical Investigation Mixing old and young: enhancing rejuvenation and accelerating aging Ashley Lau,1 Brian K. Kennedy,2,3,4,5 James L. Kirkland,6 and Stefan G. Tullius1 1Division of Transplant Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 3Singapore Institute for Clinical Sciences, Singapore. 4Agency for Science, Technology and Research (A*STAR), Singapore. -
Who Wants to Live Forever? Reader’S Digest
HEALTH Who Wantsto Live Forever? As a species, we humans appear to be the undisputed masters of our planet. Moreover, since Yuri Gagarin’s inaugural space flight in 1961, we can even leave the confines of Earth to travel in space. Yet, we have one Achilles’ heel—we’re mortal BY CHRIS MENON 1234567890 1234567890 36 BRAIN LIGHT/ALAMY STOCK PHOTO WHO WANTS TO LIVE FOREVER? READEr’s DIGEST T 122 YEARS, THE MAXIMUM HUMAN LIFESPAN lags well behind some species of giant tortoise (188 years), Greenland shark (400 years) and the record set by the lowly Icelandic clam (507 years). Even those relatively few humans who do manage to make it past 100—some 14,570 people in the UK in 2015—are invariably bedeviled byA poor health. Recently, efforts to extend the healthy of Amazon, has similarly invested human lifespan have achieved much in Unity Biotechnology, which aims publicity following the backing of “to design therapeutics that prevent, visionary, super-rich Silicon Valley halt, or reverse diseases of ageing”. tech entrepreneurs. In 2013, Google’s Unity intends to develop a new founders created a subsidiary class of therapies called “senolytic company called Calico (short for medicines”, designed to selectively the California Life Company), eliminate senescent cells. Senescent Billionaire researchers, which promptly hired a team of top cells accumulate with age and, Some believe that death, Arthur Levinson, Jeff technologies that scientists and now has more than unlike normal cells, they secrete like any disease, can be Bezos and Elon Musk the SENS Research £1bn in the bank to fund its work. -
Le Sénonais : Le Défi De L’Attractivité
INSEE BOURGOGNE N°129-Mars2006-2,30euros Le Sénonais : le défi de l’attractivité Le Sénonais profite de sa Le Sénonais : un arrondissement aux portes de l'Île-de-France situation géographique aux portes de l’Île-de-France. Il attire des retraités franciliens, comme les arrondissements voisins de Montargis ou Troyes, mais aussi des jeunes ménages avec enfants. Les nouveaux arrivants tirent le profil social vers le "haut". L’économie locale, bien que créatrice d’emplois, n’arrive pas à absorber la hausse du nombre d’actifs. Le chômage est élevé et les déplacements domicile- travail en direction de l’Île- de-France s’intensifient. Parallèlement, l’arrondissement profite du desserrement des activités franciliennes. Source : Insee - Recensement de la population de 1999. Cet article est extrait d'un rapport d'étude réalisé par l'Insee-Bourgogne en partenariat avec la Direction Régionale de l'Équipement de Bourgogne. L'arrondissement de Sens, appelé ici Sénonais, est analysé en comparaison avec les arrondissements voisins de Troyes, Montargis, Auxerre et Avallon. INSEE BOURGOGNE N°129-Mars2006-2,30euros ’arrondissement de Sens, est situé Lau nord de la Bourgogne, aux por- Espaces ruraux et urbains du Sénonais tes de l’Île-de-France, à mi-chemin entre Troyes et Montargis. Il bénéficie d’une excellente desserte autoroutière : ?? Marigny-le-ChâtelMarigny-le-Châtel ?? il est traversé par les autoroutes A5 et Bray-sur-SeineBray-sur-Seine Montereau-Montereau- A6 qui mènent de Paris au Sud de la ??Montereau-Montereau- ?? Fault-YonneFault-Yonne France. Un barreau autoroutier trans- Marcilly-le-HayerMarcilly-le-Hayer versal assure actuellement la jonction ?? ?? entre l’A6 et l’A5 et devrait être prolon- Villeneuve-la-GuyardVilleneuve-la-Guyard gé, à l’horizon 2010, afin de relier Troyes, Sens, Orléans et Tours. -
La Taxe D'aménagement
YONNE La Taxe d’Aménagement - TA - CompignyCompigny VinneufVinneuf Courlon-Courlon-Courlon- VilleneuveVilleneuve Plessis-Plessis- PerceneigePerceneige VilleneuveVilleneuve sur-sur-sur- sur-sur-sur- Saint-Saint- la-Guyardla-Guyardla-Guyard Saint-Saint- YonneYonne SerginesSergines YonneYonne JeanJeanJean PaillyPailly Saint-Maurice-aux-Saint-Maurice-aux- VilleblevinVilleblevin SerbonnesSerbonnes Riches-HommesRiches-Hommes ChampignyChampigny MicheryMichery ChaumontChaumont LaLa Thorigny-sur-OreuseThorigny-sur-Oreuse Saint-AgnanSaint-Agnan Saint-AgnanSaint-Agnan VillemanocheVillemanoche Chapelle-Chapelle- Gisy-les-Gisy-les- Chapelle-Chapelle- CourgenayCourgenay Pont-sur-Pont-sur- sur-sur- LaLa PostollePostolle Pont-sur-Pont-sur- NoblesNobles sur-sur-sur- LaLa PostollePostolle YonneYonne OreuseOreuse VillethierryVillethierry EEvvvrrryyy VillethierryVillethierry LaillyLailly BagneauxBagneaux VilleperrotVilleperrot CuyCuy VoisinesVoisines Saint-Saint- SoucySoucy LixyLixy VillenavotteVillenavotte Villeneuve-Villeneuve- SérotinSérotin Villeneuve-Villeneuve- Saint-Denis-lès-SensSaint-Denis-lès-Sens ValleryVallery Foissy-Foissy- l'Archevêquel'Archevêquel'Archevêque ValleryVallery Courtois-sur-Courtois-sur- Fontaine-la-Fontaine-la- LesLesLes Foissy-Foissy- BrannayBrannay Saint-ClémentSaint-Clément Gaillarde sur-sur-sur- NaillyNailly YonneYonne Saint-ClémentSaint-Clément GaillardeGaillarde ClérimoisClérimois sur-sur- MolinonsMolinons SalignySaligny DollotDollot Saint-Martin-Saint-Martin- VanneVanne FlacyFlacy VillebougisVillebougis Saint-Martin-Saint-Martin- -
From Here to Immortality: Anti-Aging Medicine
FromFrom HereHere toto Immortality:Immortaalitty: AAnti-AgingAnnntti-AAgging MMedicineedicine Anti-aging medicine is a $5 billion industry. Despite its critics, researchers are discovering that inter ventions designed to turn back time may prove to be more science than fiction. By Trudie Mitschang 14 BioSupply Trends Quarterly • October 2013 he symptoms are disturbing. Weight gain, muscle Shifting Attitudes Fuel a Booming Industry aches, fatigue and joint stiffness. Some experience The notion that aging requires treatment is based on a belief Thear ing loss and diminished eyesight. In time, both that becoming old is both undesirable and unattractive. In the memory and libido will lapse, while sagging skin and inconti - last several decades, aging has become synonymous with nence may also become problematic. It is a malady that begins dete rioration, while youth is increasingly revered and in one’s late 40 s, and currently 100 percent of baby boomers admired. Anti-aging medicine is a relatively new but thriving suffer from it. No one is immune and left untreated ; it always field driven by a baby- boomer generation fighting to preserve leads to death. A frightening new disease, virus or plague? No , its “forever young” façade. According to the market research it’s simply a fact of life , and it’s called aging. firm Global Industry Analysts, the boomer-fueled consumer The mythical fountain of youth has long been the subject of base will push the U.S. market for anti-aging products from folklore, and although it is both natural and inevitable, human about $80 billion now to more than $114 billion by 2015. -
SENS-Research-Foundation-2019
by the year 2050, cardiovascular an estimated 25-30 the american 85 percent of adults disease years and older age 85 or older remains the most population will suffer from common cause of 2 1 2 dementia. death in older adults. triple. THE CLOCK IS TICKING. By 2030, annual direct The estimated cost of medical costs associated dementia worldwide was 62% of Americans with cardiovascular $818 billion diseases in the united over age 65 have in 2015 and is states are expected to more than one expected to grow to rise to more than chronic condition.1 3 $2 trillion $818 billion. by 2030.1 References: (1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732407/, (2) https://www.who.int/ageing/publications/global_health.pdf, (3) https://www.cdcfoundation.org/pr/2015/heart-disease-and-stroke-cost-america-nearly-1-billion-day-medical-costs-lost-productivity sens research foundation board of directors Barbara Logan Kevin Perrott Bill Liao Chairperson Treasurer Secretary Michael Boocher Kevin Dewalt James O’Neill Jonathan Cain Michael Kope Frank Schuler 02 CONTENTS 2019 Annual Report 04 Letter From The CEO 06 Outreach & Fundraising 08 Finances 09 Donors erin ashford photography 14 Education 26 Investments 20 Conferences & Events 30 Research Advisory Board 23 Speaking Engagements 31 10 Years Of Research 24 Alliance 32 MitoSENS 34 LysoSENS 35 Extramural Research 38 Publications 39 Ways to Donate cover Photo (c) Mikhail Leonov - stock.adobe.com special 10th anniversary edition 03 FROM THE CEO It’s early 2009, and it’s very late at night. Aubrey, Jeff, Sarah, Kevin, and Mike are sitting around a large table covered in papers and half-empty food containers. -
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5 EVENTS in ONE: Head Real World Evidence and Big Data Solutions Novartis, Switzerland
FIFTH ANNUAL - LIFE SCIENCE R&D DATA INTELLIGENCE LEADERS FORUM Basel, Switzerland January 23-24th, 2018 Optional Workshop 22nd, January Hear keynote presentations from the experts: Etzard Stolte Global Head Knowledge Management Roche, Switzerland Abhimanyu Verma 5 EVENTS IN ONE: Head Real World Evidence and Big Data Solutions Novartis, Switzerland Day 1: Torsten Niederdraenk Head of Technology Center Strategic Developments in R&D Big Siemens Healthcare, Germany Data Catherine Brownstein Scientific Director Day 2 (am): Stream 1 Manton Center for Orphan Disease Research Boston Children’s Hospital, USA Discovery & Omics Data Excellence Navin Ramachandran Radiology Consultant Day 2 (am): Stream 2 University College London Hospitals NHS Foundation Trust, Healthcare specialist in distributed ledgers and IoT Clinical & Patient Level Data IOTA Foundation, UK Excellence Marie-Claire Peakman Executive Director, Head Hit Discovery & Lead Profiling, Medicine Design Day 2 (pm): Stream A Pfizer, USA R&D IT & Bioinformatics Alex Zhavoronkov Co-founder, Insilico Medicine, CSO Day 2 (pm): Stream B The Biogerontology Research Foundation, UK Ivana Schnur Digital Health Collaborations Co-founder, CMO Sense.ly, USA Pre-Event Workshop: Jan 22nd Paul Wicks Artificial Intelligence for Drug Vice President of Innovation PatientsLikeMe, UK Discovery: Workshop for Senior Jazz Panchoo Global Strategy Head, VP, Digital Platforms Executives Ascensia Diabetes Care, Switzerland This Event is Certified for Continuing Professional Development with more than 30 presentations -
Loire / Nivernais
Paris Strasbourg Nantes Lyon Bordeau Toulouse Marseille LOIRE / NIVERNAIS LA CHARITÉ-SUR-LOIRE Canal de Briare - Canal latéral à La Loire - Canal du Nivernais - L'Yonne This is an easy to access cruising region as close to Paris (about 2h or 2h30 depending on your starting point at either Rogny or Plagny). Explore numerous historical sites and enjoy internationally renowned Sancerre wines and excellent local gastronomy. There are a wide range of cruise itineraries on both canals and the river Yonne. FROM PLAGNY AND ROGNY-LES-SEPT-ÉCLUSES The Canal de Briare runs parallel to the Loire River and the superb an essential stop on the route to ‘Saint-Jacques-de-Compostella’ Canal du Nivernais and offers peaceful waters alongside the rhythm Apremont-sur-Allier ranked among the most beautiful villages in of enchanting French village life. Set in surroundings between hills France and Nevers, a town full of art, history and famous for its and forests the area is dotted with remarkable sites such as: Rogny cathedral and gothic dukes’ palace, its Roman church from the 11th with its seven locks built during the realm of Henry IV ; the Briare century and some of the oldest potteries in France. Lastly nature canal bridge designed by Eiffel ; Sancerre and pouilly, renowned lovers should visit Bec d’Allier – the meeting point between Loire for their world famous vineyards ; la Charité sur Loire (city of and Allier, one of the last wild rivers in Europe and classified a books) which is classified by UNESCO as a World Heritage Site and ‘Panda Site’ by the WWF. -
Age-Dependent Deterioration of Nuclear Pore Assembly in Mitotic
RESEARCH ARTICLE Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics Irina L Rempel1, Matthew M Crane2, David J Thaller3, Ankur Mishra4, Daniel PM Jansen1, Georges Janssens1, Petra Popken1, Arman Aks¸it1, Matt Kaeberlein2, Erik van der Giessen4, Anton Steen1, Patrick R Onck4, C Patrick Lusk3, Liesbeth M Veenhoff1* 1European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, Netherlands; 2Department of Pathology, University of Washington, Seattle, United States; 3Department of Cell Biology, Yale School of Medicine, New Haven, United States; 4Zernike Institute for Advanced Materials, University of Groningen, Groningen, Netherlands Abstract Nuclear transport is facilitated by the Nuclear Pore Complex (NPC) and is essential for life in eukaryotes. The NPC is a long-lived and exceptionally large structure. We asked whether NPC quality control is compromised in aging mitotic cells. Our images of single yeast cells during aging, show that the abundance of several NPC components and NPC assembly factors decreases. Additionally, the single-cell life histories reveal that cells that better maintain those components are longer lived. The presence of herniations at the nuclear envelope of aged cells suggests that misassembled NPCs are accumulated in aged cells. Aged cells show decreased dynamics of transcription factor shuttling and increased nuclear compartmentalization. These functional changes are likely caused by the presence