The UK's Leading Non-profit Foundation Specifically Focused on Longevity and the Paradigm Shift from Treatment to Prevention Provided Financing for Initial Scope of Activities for the All-Party Parliamentary Group for Longevity Produced the First Ever Longevity Industry Landscape Overview Analytical Reports Succeeded in Having the World Health Organization Add New Code for “Ageing Related” Diseases 2 Table of Contents 2 The Biogerontology Research Foundation Biogerontology Research Foundation - Summary Predicted the Rise of the Longevity Industry 3 Years in Advance The Biogerontology Research Foundation Produced Biogerontology Research Foundation Scope, History the First Ever Longevity Industry Landscape and Agenda 2019 - 2020 Overview Reports Reports by the Biogerontology Research Biogerontology Research Foundation History and Foundation and Aging Analytics Agency: 2013 - Scope of Activities 2015 The BGRF is Supporting the Activities of the UK UK Longevity Industry Landscape Overview Q4 ALl-Party Parliamentary Group for Longevity 2018 The BGRF is Supporting the Launch of an Artificial The Biogerontology Research Foundation is Intelligence Centre for Longevity at King’s College Supporting the Launch of Swiss Longevity London Foundation in Geneva, Switzerland in 2019 Biogerontology Research Foundation Board of Paradigm Shift from Treatment to Prevention Trustees The New Frontier - from Precision Medicine to Proposal for Cooperation and Collaboration Precision Health The BGRF Established Extension Code for “Ageing Related” During the World-Health Organization’s Contact Information ICD-11 Revisions Biogerontology Research Foundation - Summary 3 I. Active Involvement in UK Longevity Policy, Politics and Governance Initiatives The Biogerontology Research Foundation has always made progressive policy proposals relating to Longevity a core element of its activities, and has recently made the decision to significantly expand its scope of activities in this regard, interfacing with both national and international policy-related organizations to further the United Kingdom’s activities relating to Longevity politics and governance, including providing inputs to optimize the long-term strategy of the All-Party Parliamentary Group for Longevity’s Blueprint and Framework for a National UK Healthy Longevity Development Strategy. II. Cross-Sector Dialogue with All Major UK Longevity Industry Players A focus on cross-sector dialogue, projects and initiatives spanning government, industry, academia and other relevant spheres of activity, Longevity Swiss Foundation aims to achieve a maximum level of synergy and convergence, growing every aspect of United Kingdom’s Longevity ecosystem to scale. III. Scientific Research to Further R&D on AI for Longevity and Actionable Biomarkers of Ageing The Biogerontology Research Foundation has an extremely strong history of applying AI for ageing research (including more than a dozen peer-reviewed scientific articles and projects on this topic) and on the development of practically-implementable and actionable panels of biomarkers of ageing (such as its MouseAge crowdfunding initiative, which enabled the development of ageing biomarkers based on deep-learning analysis of photographs), and actively prioritizes collaboration on these specific niches). IV. Support of Progressive Longevity Financial Reform to Neutralize Economic Burden of Ageing Population The Biogerontology Research Foundation is committed to working alongside progressive financial institutions including pension funds, insurance companies, private wealth banks and other relevant entities to roadmap initiatives and policy proposals to turn the problem of ageing population into the economic opportunity of Healthy Longevity. Biogerontology Research Foundation Scope, History and 4 Agenda 2019 - 2020 The Biogerontology Research Foundation is the UK’s It has been working since 2008 to develop the UK’s leading non-profit focused on Longevity and on Longevity Industry and the field of Geroscience (The expediting the coming paradigm shift from disease Science of Longevity) to a level of mainstream prominence treatment to personalized precision prevention. and recognition since 2008 -- nearly a decade before the Longevity Industry rose to its current state of acceptance It was the main initial donor that provided financial and by the mainstream investors, the global scientific organisational support to Longevity International UK for community, the public and the media landscape. the purpose of establishing the APPG for Longevity. It was also actively involved in the successful initiative While the topic of Longevity is now accepted by even the of adding a new extension code for “ageing-related most conservative industry, scientific and media diseases” accepted in 2018 by the World Health professionals, it took tireless years of work to achieve, and Organization during the last revisions of its the Biogerontology Research Foundation has been on the International Classification of Diseases framework - the forefront of these developments closest any group has come to classifying ageing as a disease. The Biogerontology Research Foundation Has Been Committed for to Developing the United Kingdom's Longevity Industry, Academic Sphere and its State of Longevity Policy, Politics and Governance for More than 10 Years. Now that the UK Longevity Ecosystem has Reached a state of Unprecedented Mainstream Acceptance and Prominence, the Biogerontology Research Foundation is Expanding its Scope to Help Develop the Global Longevity Industry to Scale. Biogerontology Research Foundation History and Scope of 5 Activities 2008 Founded in 2008 by Prominent Longevity Scientists Including Alex Zhavoronkov Inspired by Dr. Aubrey de Grey and Founded in prominent Longevity Scientists including Alex Zhavoronkov, the BGRF was officially launched as a formal UK non-profit foundation in 2008. 2009 - 2017 Landmark Production of Several Global Longevity Industry Landscape Overview Analytical Reports Throughout 2008 - 2013, the BGRF produced a number of key analytical reports on industries that eventually emerged into the present unified Longevity Industry, laying the groundwork for the analytical frameworks later used for its Longevity Industry Landscape Overviews, which were officially published in 2017. This marks the first time that any entity had ever published comprehensive industry overviews of the entire global Longevity industry. 2017 - 2018 Successful Addition of New Extension Code for Age Related Diseases via World Health Organization In 2017 the Biogerontology Research Foundation submitted a proposal to classify ageing as a disease during the ICD-11 revisions. In 2018, the proposal was partially implemented in the form of a new extension code for age related diseases, the closest any organization has ever come globally to officially classifying ageing as a disease. 2018 Publication of Longevity Industry in UK Landscape Overview Q4 2018 (Second Edition) - 1100 Pages In 2018 the Biogerontology Research Foundation released a second extended edition of its previous Longevity Industry in UK Landscape Overview Report, 1100+ pages in length, which provided key inputs into the current Longevity Industry, Academic and Policy Landscape on the UK for the APPG for Longevity. 2019 Support of the Artificial Intelligence Centre for Longevity at King’s College London The Biogerontology Research Foundation supported the structuring of the strategic agenda for a new AI Centre for Longevity as part of the Ageing Research at King’s (ARK) alongside Aging Analytics Agency and Insilico Medicine, offering key inputs into how to most optimally leverage the UK’s strengths in AI R&D to help support cutting-edge AI for Longevity, Preventive Medicine and Precision Health R&D at King’s College in London. 2019 Provided Financing to Support Initial Scope of Activities for All-Party Parliamentary Group for Longevity In Q2 2019 the Biogerontology Research Foundation was the primary source of financing for the support and execution of the All-Party Parliamentary Group for Longevity initial scope of activities, and also offered key strategic inputs on the APPG for Longevity’s agenda for 2019-2020 alongside Aging Analytics Agency Biogerontology Research Foundation Agenda 2019 - 2020 6 2019 Q2 Supporting the All-Party Parliamentary Group for Longevity The BGRF will continue to support the activities of the All-Party Parliamentary Group for Longevity by offering key inputs relevant for its long-term strategy as one of its Supporting Partners. 2019 Q27 Support of AI Centres for Precision Health and LifeTime Wellness (Financial, Social, Psychological Wellness) The Biogerontology Research Foundation is utilizing its wealth of knowledge on the ways that AI can be used to accelerate R&D in Preventive Medicine, Precision Health and Longevity to support the launch of AI Centres for Longevity and AI Centres for LifeTime Wellness, to make the UK a global leader in AI for Longevity Research. 2019 Q3 Support and Launch of the Longevity Swiss Foundation The BGRF is utilizing its expertise in pushing forward progressive policy proposals with UK politics and governance organizations within the UK to help guide the launch of similar activities in Switzerland through the Longevity Swiss Foundation, a Geneva-based non-profit aiming to make Switzerland a leading international Longevity hub. 2019 Q4 Ongoing Development of Distributed Longevity Knowledge Platform Longevity.International The Biogerontology Research Foundation will continue its efforts