bioRxiv preprint doi: https://doi.org/10.1101/236232; this version posted December 18, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Fibroblast state switching orchestrates dermal maturation and wound healing Emanuel Rognoni1,2, Angela Oliveira Pisco1,2, Toru Hiratsuka1, Kalle Sipilä1, Julio Belmonte3, Seyedeh Atefeh Mobasseri1, Rui Dilão4 and Fiona M. Watt1* 1Centre for Stem Cells and Regenerative Medicine, King’s College London, 28thFloor, Tower Wing, Guy’s Hospital Campus, Great Maze Pond, London SE1 9RT 2Equal contribution 3Developmental Biology Unit and Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany 4Nonlinear Dynamics Group, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal *Corresponding author:
[email protected] Key words: dermis development, fibroblast states, mathematical modelling, tissue architecture, wound healing 1 bioRxiv preprint doi: https://doi.org/10.1101/236232; this version posted December 18, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Summary Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to proliferate in early postnatal life. Here we propose a mathematical model in which a negative feedback loop between extracellular matrix (ECM) deposition and fibroblast proliferation determines dermal architecture.