Endocrine Surgery Goals and Objectives
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Contents 1 Tumours of the pituitary gland 11 Spindle epithelial tumour with thymus-like differentiation 123 WHO classifi cation of tumours of the pituitary 12 Intrathyroid thymic carcinoma 125 Introduction 13 Paraganglioma and mesenchymal / stromal tumours 127 Pituitary adenoma 14 Paraganglioma 127 Somatotroph adenoma 19 Peripheral nerve sheath tumours 128 Lactotroph adenoma 24 Benign vascular tumours 129 Thyrotroph adenoma 28 Angiosarcoma 129 Corticotroph adenoma 30 Smooth muscle tumours 132 Gonadotroph adenoma 34 Solitary fi brous tumour 133 Null cell adenoma 37 Haematolymphoid tumours 135 Plurihormonal and double adenomas 39 Langerhans cell histiocytosis 135 Pituitary carcinoma 41 Rosai–Dorfman disease 136 Pituitary blastoma 45 Follicular dendritic cell sarcoma 136 Craniopharyngioma 46 Primary thyroid lymphoma 137 Neuronal and paraneuronal tumours 48 Germ cell tumours 139 Gangliocytoma and mixed gangliocytoma–adenoma 48 Secondary tumours 142 Neurocytoma 49 Paraganglioma 50 3 Tumours of the parathyroid glands 145 Neuroblastoma 51 WHO classifi cation of tumours of the parathyroid glands 146 Tumours of the posterior pituitary 52 TNM staging of tumours of the parathyroid glands 146 Mesenchymal and stromal tumours 55 Parathyroid carcinoma 147 Meningioma 55 Parathyroid adenoma 153 Schwannoma 56 Secondary, mesenchymal and other tumours 159 Chordoma 57 Haemangiopericytoma / Solitary fi brous tumour 58 4 Tumours of the adrenal cortex 161 Haematolymphoid tumours 60 WHO classifi cation of tumours of the adrenal cortex 162 Germ cell tumours 61 TNM classifi -
Endocrine Pathology (537-577)
LABORATORY INVESTIGATION THE BASIC AND TRANSLATIONAL PATHOLOGY RESEARCH JOURNAL LI VOLUME 99 | SUPPLEMENT 1 | MARCH 2019 2019 ABSTRACTS ENDOCRINE PATHOLOGY (537-577) MARCH 16-21, 2019 PLATF OR M & 2 01 9 ABSTRACTS P OSTER PRESENTATI ONS EDUCATI ON C O M MITTEE Jason L. Hornick , C h air Ja mes R. Cook R h o n d a K. Y a nti s s, Chair, Abstract Revie w Board S ar a h M. Dr y and Assign ment Co m mittee Willi a m C. F a q ui n Laura W. La mps , Chair, C ME Subco m mittee C ar ol F. F ar v er St e v e n D. Billi n g s , Interactive Microscopy Subco m mittee Y uri F e d ori w Shree G. Shar ma , Infor matics Subco m mittee Meera R. Ha meed R aj a R. S e et h al a , Short Course Coordinator Mi c h ell e S. Hir s c h Il a n W ei nr e b , Subco m mittee for Unique Live Course Offerings Laksh mi Priya Kunju D a vi d B. K a mi n s k y ( Ex- Of ici o) A n n a M ari e M ulli g a n Aleodor ( Doru) Andea Ri s h P ai Zubair Baloch Vi nita Parkas h Olca Bast urk A nil P ar w a ni Gregory R. Bean , Pat h ol o gist-i n- Trai ni n g D e e p a P atil D a ni el J. -
Genetic Landscape of Papillary Thyroid Carcinoma and Nuclear Architecture: an Overview Comparing Pediatric and Adult Populations
cancers Review Genetic Landscape of Papillary Thyroid Carcinoma and Nuclear Architecture: An Overview Comparing Pediatric and Adult Populations 1, 2, 2 3 Aline Rangel-Pozzo y, Luiza Sisdelli y, Maria Isabel V. Cordioli , Fernanda Vaisman , Paola Caria 4,*, Sabine Mai 1,* and Janete M. Cerutti 2 1 Cell Biology, Research Institute of Oncology and Hematology, University of Manitoba, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada; [email protected] 2 Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo/EPM, São Paulo, SP 04039-032, Brazil; [email protected] (L.S.); [email protected] (M.I.V.C.); [email protected] (J.M.C.) 3 Instituto Nacional do Câncer, Rio de Janeiro, RJ 22451-000, Brazil; [email protected] 4 Department of Biomedical Sciences, University of Cagliari, 09042 Cagliari, Italy * Correspondence: [email protected] (P.C.); [email protected] (S.M.); Tel.: +1-204-787-2135 (S.M.) These authors contributed equally to this paper. y Received: 29 September 2020; Accepted: 26 October 2020; Published: 27 October 2020 Simple Summary: Papillary thyroid carcinoma (PTC) represents 80–90% of all differentiated thyroid carcinomas. PTC has a high rate of gene fusions and mutations, which can influence clinical and biological behavior in both children and adults. In this review, we focus on the comparison between pediatric and adult PTC, highlighting genetic alterations, telomere-related genomic instability and changes in nuclear organization as novel biomarkers for thyroid cancers. Abstract: Thyroid cancer is a rare malignancy in the pediatric population that is highly associated with disease aggressiveness and advanced disease stages when compared to adult population. -
Validation of Algorithms to Identify Pancreatic Cancer and Thyroid Neoplasms from Health Insurance Claims Data in a 10-Year Foll
Validation of Algorithms to Identify Pancreatic Cancer and Thyroid Neoplasms From Health Insurance Claims Data in a 10-Year Follow-Up Study Caihua Liang, MD, PhD1*; Monica L Bertoia, MPH, PhD1; C Robin Clifford, MS1; Yan Ding, MSc1; Qing Qiao, MD, PhD2; Joshua J Gagne, PharmD, ScD1,3; David D Dore, PharmD, PhD1 1Optum Epidemiology, Boston, MA/Ann Arbor, MI, USA; 2Global Medical Affair AstraZeneca, Gothenburg, Sweden; 3Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA. *Corresponding author: [email protected]. This study was funded through a research contract between Optum Epidemiology and AstraZeneca. Background Methods (cont.) Identification of cancer events in health insurance claims data can be Figure 1. Pancreatic cancer and thyroid neoplasm relaxed and restricted challenging and subject to misclassification. Given the low incidence of algorithms certain cancers, robust performance evaluation requires a large sample size PANCREATIC CANCER THYROID NEOPLASMS with long-term follow-up. ICD-9 Codes ICD-9 Codes (Malignant neoplasm of …) 193 Malignant neoplasm of thyroid gland 157.X … pancreas 226 Benign neoplasm of thyroid gland Objective 157.0 … head of pancreas 157.1 … body of pancreas Thyroid Cancer Benign Thyroid Neoplasm To validate algorithms for potential incident pancreatic cancer and thyroid 157.2 … tail of pancreas neoplasms in a 10-year follow-up study using a health insurance claims 157.3 … pancreatic duct Restricted Algorithm: Restricted Algorithm: 157.4 … islets of Langerhans a+b+c a+b+c database. 157.8 … other specified sites of Relaxed Algorithm: Relaxed Algorithm: pancreas a+b or a+c a+b or a+c 157.9 … pancreas, part unspecified Data Source a. -
Significance of RAS Mutations in Thyroid Benign Nodules and Non
cancers Review Significance of RAS Mutations in Thyroid Benign Nodules and Non-Medullary Thyroid Cancer Vincenzo Marotta 1 , Maurizio Bifulco 2 and Mario Vitale 3,* 1 UOC Clinica Endocrinologica e Diabetologica, AOU S. Giovanni di Dio e Ruggi D’Aragona, 84131 Salerno, Italy; [email protected] 2 Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80100 Naples, Italy; [email protected] 3 Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy * Correspondence: [email protected]; Tel.: +39-089-672-753 Simple Summary: Only about 4% of thyroid nodules are carcinomas and require surgery. Fine- needle aspiration cytology is the most accurate tool to distinguish benign from malignant thyroid nodules, however it yields an indeterminate result in about 30% of the cases, posing diagnostic and prognostic dilemmas. Testing for genetic mutations, including those of RAS, has been proposed for indeterminate cytology to solve these dilemmas and support the clinician decision making process. A passionate debate is ongoing on the biological and clinical significance of RAS mutations, calling into question the utility of RAS as tumor marker. Recently, the description of a new entity of non- invasive follicular thyroid neoplasm and the accurate review of more recent analyses demonstrate that RAS mutations have limited utility in both the diagnostic and prognostic setting of thyroid nodular disease. Citation: Marotta, V.; Bifulco, M.; Abstract: Thyroid nodules are detected in up to 60% of people by ultrasound examination. Most Vitale, M. Significance of RAS of them are benign nodules requiring only follow up, while about 4% are carcinomas and require Mutations in Thyroid Benign surgery. -
2018 Updates for Neoplasms of the Thyroid
12/11/2018 2018 Updates for Neoplasms of the Thyroid 1 2 0 1 8 - 2019 FCDS WEBCAST SERIES 1 2 / 1 3 / 2 0 1 8 S T E V E N P E A C E , C T R CDC & Florida DOH Attribution 2 “Funding for this conference was made possible (in part) by the Centers for Disease Control and Prevention. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services, nor does the mention of trade names, commercial practices, or organizations imply endorsement by the US Government.” FCDS would also like to acknowledge the Florida Department of Health for its support of the Florida Cancer Data System, including the development, printing and distribution of materials for the 2018 FCDS Annual Conference and the 2018-2019 FCDS Webcast Series under state contract CODJU. The findings and conclusions in this series are those of the author(s) and do not necessarily represent the official position of the Florida Department of Health. 1 12/11/2018 FLccSC LMS – CEU Quiz –FCDS IDEA 3 2017 - Florida Changed How FCDS Awards CEUs for FCDS Webcasts Attendees must take and pass a 3-5 question CEU Quiz to get CEUs CEU Awards are Restricted to Attendees with a FLccSC LMS Account The CEU Quiz will be posted to FLccSC 1-2 hours after the webcast ends Only registered FLccSC Users will be given access to the CEU Quiz Florida attendees must have a Florida FLccSC Account to take the Quiz South Carolina attendees must have a South Carolina FLccSC Account -
A Clinical Study on Malignant Neoplastic Thyroid Swellings
Jebmh.com Original Research Article A Clinical Study on Malignant Neoplastic Thyroid Swellings Sumanth Mandava1, Tarun Chowdary Gogineni2, Vasu Reddy Challa3, Karthik Santosh Appaji4 Sriphani Reddy Puvvala5, T. Jaya Chandra6 1, 2, 3, 5 Department of Surgical Oncology, GSL Medical College, Rajahmundry, Andhra Pradesh, India. 4Department of General Surgery, GSL Medical College, Andhra Pradesh, India. 6Scientist in Charge, Central Research Laboratory, GSL Medical College, Andhra Pradesh, India. ABSTRACT BACKGROUND More thyroid malignancy cases occur in women. FNAC (Fine Needle Aspiration Corresponding Author: Cytology) and histopathology play a key role in resolving this diagnostic challenge. Dr. Vasu Reddy Challa, A study was conducted to correlate the age, gender parameters with the clinical Associate Professor, Department of Surgical Oncology, findings in thyroid malignancies by considering the histopathological examination GSL Medical College, Rajahmundry, (HPE) as the gold standard. Andhra Pradesh, India. E-mail: METHODS [email protected] It was a prospective study conducted in the department of Surgical Oncology, GSL Medical College, Rajahmundry, Malignant thyroid neoplasm individuals of any age, DOI: 10.18410/jebmh/2020/599 either gender who were fit thyroidectomy were included in the study. FNAC of the thyroid gland and lymph nodes was done. Data was analyzed using SPSS 21.0. Chi How to Cite This Article: square test was used to find the statistical significance. P > 0.05 was considered to Mandava S, Gogineni TC, Challa VR, et al. A clinical study on malignant neoplastic be statistically significant. thyroid swelling. J Evid Based Med Healthc 2020; 7(49), 2928-2932. DOI: RESULTS 10.18410/jebmh/2020/599 In this study, 52 HPE proven cases were studied, female male ratio was 5.5. -
Surgical Indications and Techniques for Adrenalectomy Review
THE MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL DOI: 10.14744/SEMB.2019.05578 Med Bull Sisli Etfal Hosp 2020;54(1):8–22 Review Surgical Indications and Techniques for Adrenalectomy Mehmet Uludağ,1 Nurcihan Aygün,1 Adnan İşgör2 1Department of General Surgery, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey 2Department of General Surgery, Bahcesehir University Faculty of Medicine, Istanbul, Turkey Abstract Indications for adrenalectomy are malignancy suspicion or malignant tumors, non-functional tumors with the risk of malignancy and functional adrenal tumors. Regardless of the size of functional tumors, they have surgical indications. The hormone-secreting adrenal tumors in which adrenalectomy is indicated are as follows: Cushing’s syndrome, arises from hypersecretion of glucocorticoids produced in fasciculata adrenal cortex, Conn’s syndrome, arises from an hypersecretion of aldosterone produced by glomerulosa adrenal cortex, and Pheochromocytomas that arise from adrenal medulla and produce catecholamines. Sometimes, bilateral adre- nalectomy may be required in Cushing's disease due to pituitary or ectopic ACTH secretion. Adenomas arise from the reticularis layer of the adrenal cortex, which rarely releases too much adrenal androgen and estrogen, may also develop and have an indication for adrenalectomy. Adrenal surgery can be performed by laparoscopic or open technique. Today, laparoscopic adrenalectomy is the gold standard treatment in selected patients. Laparoscopic adrenalectomy can be performed transperitoneally or retroperitoneoscopi- cally. Both approaches have their advantages and disadvantages. In the selection of the surgery type, the experience and habits of the surgeon are also important, along with the patient’s characteristics. The most common type of surgery performed in the world is laparoscopic transabdominal lateral adrenalectomy, which most surgeons are more familiar with. -
Ese-Ensat-Acc-Guidelines-13-5-2018
European Society of Endocrinology Clinical Practice Guidelines on the Management of Adrenocortical Carcinoma in Adults, in collaboration with the European Network for the Study of Adrenal Tumors Martin Fassnacht1,2*, Olaf M. Dekkers3,4,5, Tobias Else5, Eric Baudin7,8, Alfredo Berruti9, Ronald R. de Krijger10, 11, 12, 13, Harm R. Haak14,15, 16, Radu Mihai17, Guillaume Assie19, 20, Massimo Terzolo20* 1 Dept. of Internal Medicine I, Div. of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany 2 Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany 3 Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands 4 Department of Clinical Endocrinology and Metabolism, Leiden University Medical Centre, Leiden, the Netherlands 5 Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark 6 Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA 7 Endocrine Oncology and Nuclear Medicine, Institut Gustave Roussy, Villejuif, France 8 INSERM UMR 1185, Faculté de Médecine, Le Kremlin-Bicêtre, Université Paris Sud, Paris, France 9 Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Medical Oncology, University of Brescia at ASST Spedali Civili, Brescia, Italy. 10 Dept. of Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands 11 Dept. of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands 12 Dept. of Pathology, Reinier de Graaf Hospital, Delft, The Netherlands 13 Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands 14 Department of Internal Medicine, Máxima Medical Centre, Eindhoven/Veldhoven, the Netherlands 15 Maastricht University, CAPHRI School for Public Health and Primary Care, Ageing and Long-Term Care, Maastricht, the Netherlands 16 Department of Internal Medicine, Division of General Internal Medicine, Maastricht University Medical Centre+, Maastricht, the Netherlands. -
Hyperparathyroidism
HYPERPARATHYROIDISM Edited by Gonzalo Díaz-Soto and Manuel Puig-Domingo Hyperparathyroidism Edited by Gonzalo Díaz-Soto and Manuel Puig-Domingo Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Romana Vukelic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published April, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from [email protected] Hyperparathyroidism, Edited by Gonzalo Díaz-Soto and Manuel Puig-Domingo p. -
Hormonally Active Adrenocortical Carcinoma in a 24-Year Old Woman
ACS Case Reviews in Surgery Vol. 1, No. 1 Hormonally active adrenocortical carcinoma in a 24-year old woman AUTHORS: CORRESPONDENCE AUTHOR: AUTHOR AFFILIATIONS: Wachtel H1-4, Sadow PM2,4, Stathatos N3,4, Dr. Carrie Lubitz, MD, FACS 1 Massachusetts General Hospital, Dept. of Surgery, Lubitz CC1,4 Massachusetts General Hospital Div. of General & Endocrine Surgery, Boston, MA Yawkey Center for Outpatient Care, 7B 2 Massachusetts General Hospital, Dept. of 55 Fruit Street Pathology, Boston, MA Boston, MA 02114 3 Massachusetts General Hospital, Dept. of Phone: 617-643-9473 Medicine, Div. of Endocrinology, Boston, MA Fax: 617-724-3895 4 Harvard Medical School, Boston, MA Email: [email protected] Background Adrenal tumors are common and frequently identified incidentally; adrenalectomy is indicated for functional tumors, masses ≥4 cm, and cases where malignancy is suspected. Summary A 24-year old previously healthy woman presented with a six-month history of weight gain, amenorrhea, hirsutism, acne, and hypertension. Biochemical evaluation revealed hypercortisolism and elevated DHEA-S. Abdominal imaging demonstrated an 11 cm right adrenal mass, abutting the right hepatic lobe, right kidney, and inferior vena cava. The patient underwent open right adrenalectomy for the presumptive diagnosis of hormonally active adrenocortical carcinoma (ACC). The tumor was able to be mobilized from surrounding structures without requiring resection of adjacent organs. Pathological exam demonstrated a 728 g, 16.5 cm ACC with extensive necrosis, and Ki67 proliferation index of 35% and large vessel vascular invasion. Postoperatively, the symptoms of hypercortisolism, virilization, and hypertension resolved. The patient is currently undergoing adjuvant mitotane therapy and has no evidence of disease six months after surgery. -
Spectrum of Malignancy and Premalignancy in Carney Syndrome
American Journal of Medical Genetics 73:369–377 (1997) Spectrum of Malignancy and Premalignancy in Carney Syndrome Ngozi A. Nwokoro,1,2* Mary T. Korytkowski,3 Suzanne Rose,3 Michael B. Gorin,4 Mona Penles Stadler,2 Selma F. Witchel,5 and John J. Mulvihill2 1Department of Oral and Maxillofacial Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 2Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 3Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 4Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 5Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania Carney syndrome is a rare, autosomal dom- neoplastic colonic polyps; inant, multi-system disorder comprising 8 subcapsular cataracts; follic- well-characterized findings, only 2 of which ular thyroid carcinoma need be present for a definitive diagnosis. Benign neoplasms are frequent, but malig- nancies are thought to be uncommon. We INTRODUCTION have studied a family to clarify the diagno- sis and spectrum of clinical manifestations Carney syndrome (MIM number 160980) is a rare, of the syndrome and to develop guidelines multi-system, pre-neoplastic syndrome diagnosed for management. The proposita, a 34-year- when at least 2 of the following 8 findings are present: old woman had classic findings of Carney cardiac myxoma, cutaneous myxoma, myxoid mam- syndrome, invasive follicular carcinoma of mary fibroadenoma, spotty mucocutaneous pigmenta- the thyroid gland, Barrett metaplasia of the tion including lentigines and blue nevi, primary pig- esophagus, neoplastic colonic polyps, bipo- mented nodular adrenocortical disease (Cushing syn- lar affective disorder, and atypical mesen- drome), testicular tumor, growth-hormone–secreting chymal neoplasm of the uterine cervix dis- pituitary adenoma, and psammomatous melanotic tinct from the myxoid uterine leiomyoma schwannoma [Carney et al., 1985, 1986a,b; Cook et al., usually seen in this syndrome.