TQEHresearch 2009 Research Report
TQEHresearch 2009 Research Report Contents
04 DIRECTOR OF RESEARCH REPORT 06 2009 RESEARCH PUBLICATIONS IN THE SPOTLIGHT 09 ANAESTHESIA, Department of 10 CARDIOLOGY UNIT 18 CLINICAL PHARMACOLOGY UNIT 21 DERMATOLOGY UNIT 22 ENDOCRINOLOGY UNIT 24 GASTROENTEROLOGY AND HEPATOLOGY UNIT 26 GYNAECOLOGY, Department of 28 HAEMATOLOGY AND MEDICAL ONCOLOGY, The combined Departments of 34 INTENSIVE CARE UNIT 39 MEDICINE, University of Adelaide Discipline of 44 NEUROLOGY UNIT 51 NUCLEAR MEDICINE UNIT 54 NURSING RESEARCH 55 OTOLARYNGOLOGY, HEAD AND NECK SURGERY, Department of 59 PSYCHIATRY, University of Adelaide Discipline of 61 RENAL UNIT 68 RESPIRATORY MEDICINE UNIT 70 RHEUMATOLOGY UNIT 72 SURGERY, University of Adelaide Discipline of 77 THERAPEUTICS RESEARCH CENTRE, University of South Australia 80 PUBLICATIONS 93 INVITED PRESENTATIONS 105 RESEARCH SUPPORT STRUCTURES 111 AWARDS 115 ACKNOWLEDGEMENTS 116 THE QUEEN ELIZABETH HOSPITAL RESEARCH FOUNDATION
TQEHresearch Research Report 2009 2 TQEHresearch Research Report 2009 3 Professor Guy Maddern Director of Research Director of Research Report The Basil Hetzel Institute 2009 began with great enthusiasm as Alongside this move towards translational for Medical Research The groups moved into The Basil Hetzel Institute research has been the development of the Queen Elizabeth Hospital building at The Queen Elizabeth Hospital. South Australian Health and Medical Research Like all new buildings, there have been the Institute on North Terrace. The Common- inevitable problems in resolving small but wealth Government has allocated $200 irritating technical glitches but, at the time million to this new capital development and of writing this report, all but one major it is envisaged that it will have a central role problem has been satisfactorily resolved and for research in South Australia with a close the groups are enjoying their new environ- relationship to its nodes, such as the Basil ment. There can be little doubt the architec- Hetzel Institute, around the major hospitals ture has greatly facilitated co-operation not on the North Terrace precinct. This and a sense of camaraderie and team work relationship needs careful oversight and across the groups. This has led to much the next few years will be critical to ensure enthusiasm and interest in joining a number that appropriate structure, relationship and of the teams based at The Queen Elizabeth co-operation is developed. The great challenge Hospital and over the next 1–2 years it will be to use successfully all the research is anticipated a number of new research infrastructure in South Australia but have groups may well relocate to the facility. a co-ordinated approach to its endeavours and the funding available to support medical The other significant change over the last research. At this stage the general direction twelve months has been to develop five being adopted is positive and providing it is significant themes within the building carefully managed, there can be little doubt in order to optimise resources and focus that medical research within South Australia the efforts of the research community at will benefit from this enormous capital the hospital. Increasingly, the focus is on injection. The problem as always is to ensure translational research. This is particularly adequate recurrent funds are available to keep appropriate as the great strength of the staffed such a large and complex vision. Basil Hetzel Institute is its very close link to patient care. There is an abundance of As we go forward into the next decade the questions that need to be answered about site at The Queen Elizabeth Hospital has the patients being treated at the hospital adequate space for a further doubling of the and using the research infrastructure to Research Institute size and efforts to obtain tackle some of these important questions funding and groups for this are now being seems logical and appropriate. actively pursued.
TQEHresearch Research Report 2009 4 “There is an abundance of questions that need to be answered about the patients being treated at the hospital and using the research infrastructure to tackle some of these important questions seems logical and appropriate.”
TQEHresearch Research Report 2009 5 “The great challenge 2009 Research Publications in the spotlight in Neurology is how to repair the brain Perugini M, Kok CH, Brown AL, Wilkinson The 2009 H1N1 virus is very topical and following damage CR, Salerno DG, Young SM, Diakiw SM, had a substantial effect on ICUs during from stroke, Lewis ID, Gonda TJ, D’Andrea RJ. Repres- the winter in Australia and New Zealand. sion of Gadd45alpha by activated FLT3 and This publication will assist planning for the neurodegenerative GM-CSF receptor mutants contributes to treatment of patients during the winter in diseases (such as growth, survival and blocked differentiation. the Northern Hemisphere. A/Professor Sandra Parkinson’s and Leukemia 2009; 23:729-738. Peake is a member of the study Management Committee. Alzheimer’s disease) Impact Factor: 8.6 and trauma.” The publication from Richard D’Andrea’s Arthur A, Shi S, Zannettino AC, Fujii N, group in Leukemia in 2009 describes the Gronthos S, Koblar SA. Implanted adult role of a growth regulatory gene (encoding human dental pulm stem cells induce the Growth Arrest and DNA Damage 45 endogenous axon guidance. Stem Cells 2009: alpha protein) that is down-regulated in 27(9):2229-37. Acute Myeloid Leukaemia (AML), particularly in AML’s that harbour the common FLT3 Stem Cells impact factor 7.9 mutation. In dissecting the mechanism by which leukaemic cells alter expression of this ‘Regenerative medicine is a new and exciting gene and obtain a growth advantage this field which involves stem cell biology and work has described an important change surgical transplantation to treat a myriad of that can be potentially targeted in the diseases. The great challenge in Neurology treatment of AML. Importantly this study is how to repair the brain following damage included cell line studies and studies with from stroke, neurodegenerative diseases AML patient samples validating the role of (such as Parkinson’s and Alzheimer’s disease) this pathway. These studies set the stage for and trauma. The data from this study was mouse experiments to determine the ability highly significant as it demonstrated for the of this pathway to cooperate with other first time how adult human stem cells from events that contribute to AML. the tooth produce factors which can actively rewire the nervous system. This finding has led to pre-clinical animal studies looking at ANZIC Influenza Investigators, Webb SA, how stem cell therapy may repair the brain Pettilä V, Seppelt I, Bellomo R, Bailey M, following a stroke. The work was undertaken Cooper DJ, Cretikos M, Davies AR, Finfer by the Stroke Research Programme which is a S, Harrigan PW, Hart GK, Howe B, Iredell collaboration between the laboratories at the JR, McArthur C, Mitchell I, Morrison S, Basil Hetzel Institute for Medical Research, Nichol AD, Paterson DL, Peake S, Richards TQEH, the School for Molecular and Biomed- B, Stephens D, Turner A, Yung M. Critical ical Sciences, University of Adelaide and a care services and 2009 H1N1 influenza in long-term collaborator A/Prof Stan Gronthos Australia and New Zealand. N Engl J Med. from the Division of Haematology, Hanson 2009 Nov 12; 361(20):1925-34. Institute, Adelaide.’
This publication has been published by the Foreman A, Singhal D, Psaltis AJ, Wormald New England Journal of Medicine, the top PJ. Targeted imaging modality selection for ranked journal. The investigators were able bacterial biofilms in chronic rhinosinusitis. to obtain 100% case ascertainment for all Laryngoscope 2009; Nov 30. [Epub ahead of Australia and New Zealand and calculated print] per million inhabitants, the numbers of ICU admissions, bed-days, and days of mechan- Impact Factor 1.8 ical ventilation due to infection with the 2009 H1N1 virus. Data was also collected Chronic Rhinosinusitis (CRS) is an extremely on demographic and clinical characteris- common condition, encountered regularly by tics of the patients and on treatments and all ENT surgeons. However it is a challenging outcomes. condition to manage because current
TQEHresearch Research Report 2009 6 therapeutic regimes lack specificity. This is HL in a representative sample of people with “The results of this primarily because the underlying pathogen- asthma has not been reported however. In esis of this condition is poorly understood subjects with asthma identified in the 2008 research provide and therefore treatment options cannot be South Australian Health Omnibus Study, evidence-based specifically targeted against an underlying increased symptoms, functional impairment, guidelines to cause. Recently biofilms have been proposed and significant health care use were more as a potential instigator of this disease and common in people with less HL in analyses assist researchers the role they play in CRS has developed into adjusted for age, sex, and education. This in identifying one of the hottest topics in ENT research. suggests that HL is not merely acting as a Clinically this is a highly relevant area of proxy for education. Asthma itself, however, situations in which research because unlocking the pathogenesis was not increased in people with low health each technique is of CRS will eventually enable the develop- literacy, consistent with the notion that HL ment of targeted anti-biofilm treatments affects asthma management and interac- ideally suited and that can improve the outcomes of our CRS tions with health services rather than factors ensures they select patients. In the mean time our primary associated with the development of asthma. the appropriate research aim is to better understand the These findings indicate that the considera- nature and specific characteristics of bacteria tion of HL across all asthma clinical practice technique that is within the biofilms as well as outline the host and self-treatment education should be a best able to answer response to these bacterial colonies. This priority in attempts to address the ongoing paper uses sinonasal mucosal specimens community burden of asthma morbidity. their research from CRS patients to directly compare the question.” two most commonly used microscopic techniques for biofilm detection. The results Barkun JS, Aronson JK, Feldman LS, Maddern of this research provide evidence-based GJ, Strasberg SM; Balliol Collaboration, guidelines to assist researchers in identi- Altman DG, Barkun JS, Blazeby JM, Boutron fying situations in which each technique is IC, Campbell WB, Clavien PA, Cook JA, ideally suited and ensures they select the Ergina PL, Flum DR, Glasziou P, Marshall appropriate technique that is best able to JC, McCulloch P, Nicholl J, Reeves BC, Seiler answer their research question. Thus this CM, Meakins JL, Ashby D, Black N, Bunker paper will have a significant impact on future J, Burton M, Campbell M, Chalkidou K, research in this area. Furthermore, biofilms Chalmers I, de Leval M, Deeks J, Grant A, are being recognised as being involved in the Gray M, Greenhalgh R, Jenicek M, Kehoe pathogenesis of other diseases of the ears S, Lilford R, Littlejohns P, Loke Y, Madhock (otitis media with effusion), nose and throat R, McPherson K, Rothwell P, Summerskill B, (chronic tonsillitis) so this research is relevant Taggart D, Tekkis P, Thompson M, Treasure T, for our wider specialty, justifying our decision Trohler U, Vandenbroucke J. Evaluation and to seek publication in the peak journal of our stages of surgical innovations. Lancet. 2009 specialty- The Laryngoscope. In summary, Sep 26;374(9695):1089–1096. we hope this research will assist future work in this area and expedite our path towards Lancet Impact Factor 28.4 our goal of developing novel anti-biofilm treatment strategies that can improve our This was a paper that highlighted the patient’s outcomes. challenge of conducting high quality research within a surgical context. It was part of three papers put together over a Adams RJ, Appleton S, Hill CL, Ruffin RE. number of years to explain the process of Inadequate health literacy is associated with surgical research, why it is different and increased asthma morbidity in a popula- how its differences can be corrected for. tion sample. Journal of Allergy and Clinical The paper has defined a very clear agenda Immunology. 2009; 124:601-3. to improve of surgical research in order to give it the same quality and scientific rigor Journal of Allergy and Clinical Immunology associated with much of the work conducted Impact Factor 9.8 within the pharmaceutical industry. The paper is an important benchmark by which Health literacy (HL) enables patients to future surgical research will be judged and understand and to act in their own interests offers a clear and unambiguous path for and is associated with health status, preven- aspiring surgeons to follow in their research tive health behaviours, and health care costs. endeavours.
TQEHresearch Research Report 2009 7 Bonder CS, Sun WY, Matthews T, Cassano C, Li X, Ramshaw HS, Pitson SM, Lopez AF, Coates PT, Proia RL, Vadas MA, Gamble JR. Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood 2009 Feb 26;113(9):2108-17.
Blood Impact Factor 10.8
This work describes a new therapeutic role for a rare group of blood stem cells called endothelial progenitor cells in repair of damaged organs. In this study, these cells were shown to improve the recovery of kidneys damaged by interruption of their blood supply. The renal group at The Queen Elizabeth Hospital performed the experi- ments to show this phenomenon for the first time. This paper has lead other researchers to explore the potential of these cells to improve the recovery of the kidney after transplanta- tion and other surgical procedures such as abdominal aneurysm repair and to investi- gate the role of these cells in improving survival of pancreatic islet cell transplants.
Rogers NM, Lawton PD, Jose MD. Indigenous Australians and living kidney donation. N Engl J Med. 2009, 8;361(15):1513-6.
Impact Factor 50.0
The basis of living kidney donation hinges on the fact that there is no long-term detrimental effect to the donor although this has only been studied in Caucasian popula- tions. Indigenous peoples have a high rate of chronic kidney disease and questions arise as to whether they should be used as living donors despite fulfilling standardised donor work-up. This study is the first to demonstrate inferior donor outcomes when an Indigenous population has donated kidneys.
TQEHresearch Research Report 2009 8 Department of Anaesthesia
Dr Roelof van Wijk
Overview pates in the redesign and implementation of “ The Department The Department of Anaesthesia, The Queen undergraduate teaching in Anaesthesia and Elizabeth Hospital, provides Anaesthetic Pain Medicine for medical students, together of Anaesthesia services to Surgery, Cardiology, Imaging, with other Departments and disciplines is engaged in Psychiatry, and the Pregnancy Advisory within the region. teaching airway Centre. Our Acute Pain Service provides advice and postoperative pain management Research is focused on: skills for services throughout the Hospital. (i) regional anaesthesia anatomy, imaging Resuscitation, and techniques, in collaboration with The Department is part of the SA/NT TQEH Radiology Department; Ambulance staff Anaesthetic Rotation Scheme for the training (ii) predictors of acute postoperative pain, and the Emergency of Registrars in Anaesthesia. It is engaged with special focus on psychosocial in teaching airway skills for Resuscitation, predictors (CaReSS-project), Department, Ambulance staff and the Emergency Depart- in collaboration with the Department of and also involved ment, and also involved in the assessment Psychology at the University of Adelaide in the assessment of rural General Practitioners for Anaesthetic and TQEH Psychiatry privileges. We provide lectures and bed-side Department; and of rural General teaching sessions for fourth to sixth year (iii) airway management techniques. Practitioners medical students. The Department partici- for Anaesthetic
Staff R Steiner FANZCA privileges. ” Head of Department H Stevens FANZCA R van Wijk MD PhD FANZCA FFPMANZCA G Tham FANZCA V Thiruvenkatarajan FANZCA Consultants T Visvanathan FANZCA R Balasingam FANZCA R Watts FRACGP A Colby FANZCA P Woodhouse FANZCA A Czuchwicki FANZCA K France FANZCA Consultant Physician T George FANZCA C Gibb FRACP E Holt FANZCA J Jeyadoss FANZCA Visiting Medical Officers M Kha FANZCA M Alam FANZCA G Koo FANZCA E Chye FANZCA E Krishnappa FANZCA J Currie FFARCS A Laver FANZCA P Naderi FANZCA R Lea FANZCA G Newcombe FANZCA P Chien Lim FANZCA K Peng Ng FANZCA R Limb FRCA FANZCA A Sen FANZCA A Michael FANZCA G Miller FFARCS(I) FANZCA Nurse Practitioner R Mitchell FANZCA J Tonkin CNC A Moffat FFARCS D Nemeth FANZCA Grant K Osborn FANZCA TQEH Research Foundation. (Small grant A Rainbird FANZCA 2009) Targeted Cognitive Behavioural Therapy A Rajbhoj FANZCA on catastrophic thinking and peri operative V Rao Kadam FANZCA pain. ($7,305 2009) Jarvis K, Steele A, Tonkin R Sethi FANZCA J, van Wijk R.
TQEHresearch Research Report 2009 9 Department of Cardiology Research focus The Cardiology Unit has recently undertaken formal association with other TQEH researchers in Clinical Pharmacology and Vascular Surgery, and researchers in the Physiology Department, University of Adelaide, to form the TQEH Vascular Disease and Therapeutics Research Group.The overall research focus of the enlarged group is on development of new therapeutic modalities for cardiovascular diseases, utilising a translational, “bench to bedside” approach. Professor John Horowitz
yet seldom experience an acute myocar- Overview dial infarct. However they are consider- Early Reperfusion Therapies for Acute ably disabled, as many patients experience Myocardial Infarction recurrent chest pain that responds poorly (A/Prof J Beltrame) to conventional vasodilatory anti-anginal The emergency treatment of acute myocar- agents. In isolated vessel studies, we have dial infarction has undergone a rapid shown that microvessels respond differently evolution in the past 25 years with coronary to large vessels and thus we must re-examine artery angioplasty and stenting being consid- the vascular pharmacology of these vessels ered the optimal therapy to re-establish if we are to develop new therapies for coronary patency. Clinical studies being these microvascular disorders. Our basic undertaken at TQEH are examining pharma- vasomotor research program is exploring cologic therapies which may further enhance novel vasomotor therapies including the use these mechanical treatments. of statins, endothelin blockers, rho-kinase inhibitors, and calcium T-channel blockers. The IVANA trial (Intravenous Verapamil and Nitrates in Acute Myocardial Infarction) is a Reflecting the translational nature of our multi-centre study supported by the National basic research studies into clinical outcomes, Heart Foundation and co-ordinated by we have recently evaluated the clinical TQEH. This novel study will establish if readily benefits of an endothelin blocker (bosentan) available vasodilator therapy (Verapamil and in preventing angina in patients with the Nitroglycerin) promptly restores coronary coronary slow flow phenomenon. The last artery patency in patients with ST elevation of the required patients have been recruited myocardial infarction. Patient recruitment into this important study and the results was completed in December 2009 and data should be available early in the new year. analysis is in progress for this potentially ground-breaking study. In addition to the above basic and clinical studies, our research has been evaluating The early use of N-acetylcysteine in acute the morbidity associated with microvas- myocardial infarction (NACIAM) study cular disorders, specifically the impact on was initiated with the completion of the symptom status and quality of life. These IVANA study. This study examines the original studies will provide important cardio protective benefit of N-acetylcysteine insights into the health burden of these in ST elevation myocardial infarction by microvascular disorders. ascertaining if it reduces infarct size. Impact of Coronary Heart Disease on Mechanisms and Therapeutics of Quality of Life (A/Prof J Beltrame) Coronary Microvascular Disorders The above quality of life studies have been (A/Prof J Beltrame) extended to patients with obstructive The coronary slow flow phenomenon is a coronary artery disease and have already coronary microvascular disorder that was provided significant insights into populations initially characterised at TQEH. Our studies with angina. In particular, our observational demonstrated that these patients frequently studies at TQEH have corroborated a major manifest as an acute coronary syndrome clinical trial of angina therapies.
TQEHresearch Research Report 2009 10 The Clinical Utility of Coronary CT study of the effects of perhexiline (the IMPASS “The relationship Angiography (A/Prof J Beltrame) investigation) and also an evaluation of the The non-invasive assessment of coronary effects of ramipril in rabbits. of this improvement artery stenoses by CT angiography has to our recent considerably advanced in recent years. How Metabolic anti-ischaemic agents demonstration that to optimally utilise this technology in routine (A/Prof J Kennedy, Prof J Horowitz) clinical practice remains unclear. In close Our recent research has shown that perhexiline markedly collaboration with TQEH Radiology Depart- perhexiline, already known to be effective improves the efficiency ment, we are investigating the clinical utility of in relieving angina in patients who are coronary CT as compared with conventional unresponsive to other therapies, also of oxygen utilisation of non-invasive imaging techniques in reducing improves left ventricular function in patients the myocardium, the need for additional investigations such as with heart failure. The relationship of this invasive coronary angiography. improvement to our recent demonstra- as well as suppressing tion that perhexiline markedly improves inflammatory changes Depression in Patients with Coronary the efficiency of oxygen utilisation of the in white blood cells, Heart Disease (A/Prof J Beltrame) myocardium, as well as suppressing inflam- In collaboration with TQEH Department of matory changes in white blood cells, valvular valvular cells and Psychiatry, studies are being undertaken to cells and endothelial cells, is under investiga- endothelial cells, is examine the impact of depression on patients tion. The focus of current investigation is with coronary heart disease. Therapeutic the finding that perhexiline improves cardiac under investigation.” strategies to manage these patients are also function in patients with severe heart failure: being assessed. Currently, in conjunction with We are examining potential links between the TQEH Department of Psychiatry and Univer- anti-inflammatory and metabolic modulating sity of South Australia researchers, we are effects of the drug. We are also interested examining the anti-depressant effects of fish in evaluating the effects of perhexiline as oils in patients with coronary artery disease. an adjunct to reperfusion therapy in acute myocardial infarction. We have therefore Pathogenesis of aortic stenosis developed a regimen for acute treatment of (Prof J Horowitz, A/Prof J Kennedy, patients with evolving myocardial infarction Dr O Akbar Ali, Dr Y Chirkov, Dr D Ngo, with perhexiline. Dr A Sverdlov) Aortic stenosis (AS) is the most common The Role of p53 in Heart Failure cause of valvular heart disease in the (Dr A Holmes) Australian population. It affects individuals The transcription factor p53 has important particularly as they age. We are trying to roles in regulating gene expression of key develop therapies to retard the progression cellular processes such as oxidative stress, of aortic stenosis and thus decrease the mitochondrial respiration, glycolysis, and need for valve replacement. Components of fibrosis. Studies being conducted at TQEH the research in this regard include creation will examine if myocardial p53 function of a tissue culture model of aortic valve contributes to changes in these cellular disease, development of aortic stenosis processes in ageing and heart failure in rabbits treated with vitamin D supple- ments, and preparation of a human data Optimising the effects of Nitrates and base for patients with early stages of aortic Nitric Oxide in arteries and platelets stenosis (“aortic sclerosis”). Studies in a (Prof J Horowitz, Dr Y Chirkov, cohort of 255 ageing normal subjects have A/Prof J Kennedy) identified dysfunction in the aortic valve The basis for this research is related to the endothelial layer and of circulating platelets following observations. Firstly, nitric oxide, as potential target areas in such patients. which is released from the endothelial lining A follow up study is being undertaken to of blood vessels and prevents spasm and identify patients at risk for rapid progres- thrombosis of these vessels, becomes less sion of disease. We have also identified effective in patients who are prone to the the congenital condition of bicuspid aortic development of coronary events. This valve as a potential model of valve disease phenomenon, of nitric oxide resistance, has resulting from lack of nitric oxide effect. We been shown by our group to be a major are also evaluating the possible effects of a prognostic marker. The second related observa- number of agents in improving outcomes tion is that drugs used in the treatment of heart in aortic stenosis. This includes a clinical disease such as nitroglycerin, (a nitric oxide
TQEHresearch Research Report 2009 11 “ The success of donor) become less effective with the passage success of such interventions has led to the of time, a phenomenon known as nitrate wide spread clinical utilisation of nurse lead such interventions tolerance. outreach programs for patients with chronic has lead to the heart disease. The nature of these programs wide spread clinical We are interested in developing strategies varies somewhat, and it is important to to circumvent both of these problems. We delineate the optimal program for patient utilisation of nurse have demonstrated that a number of forms outcomes. We have demonstrated that the lead outreach of therapy calculated at reducing redox protocol developed at TQEH is associated stress improve tissue responsiveness to with reduced admissions as well as improved programs for nitric oxide. Such therapeutics include ACE survival over a 10-year period. An ongoing patients with inhibitors, perhexiline, possibly cholesterol research program will compare this protocol lowering, and certainly improved diabetic with related forms of clinic-based interven- chronic heart control in diabetics. tion in patients with chronic heart failure. disease.” We are also investigating the potential Pathogenesis of Tako-Tsubo Cardiomy- role of the nitroxyl anion as a means of opathy – “Broken Heart Syndrome” optimising vasodilator function. Since we (Prof J Horowitz, A/Prof J Beltrame, have previously shown that responsiveness Dr S Unger, A/Prof J Kennedy, of tissues to nitric oxide may be attenuated Dr Y Chirkov) in high risk groups of patients, we wish to Tako-tsubo cardiomyopathy is an examine potential means for circumventing uncommon but interesting condition this problem. Both novel donors of nitroxyl that mimics acute myocardial infarction anion and “direct” activators of soluble although there is no evidence of coronary guanylate cyclise are under investigation. artery disease. The condition often occurs in women and is typically precipitated by Platelet and Endothelial Dysfunction in severe emotional stress. While the condition the Polycystic Ovary Syndrome maybe life threatening in its acute presenta- (Prof J Horowitz) tion, the long term prognosis is generally The polycystic ovary syndrome is a common good. Utilising basic laboratory studies and cause of menstrual disturbances and impaired clinical cardiac magnetic resonance imaging fertility. Many people with polycystic ovary techniques, important advances have syndrome are obese and there is an increased been made at TQEH in understanding the risk of diabetes. It has been suggested for mechanisms responsible for this disorder. some time that polycystic ovary syndrome may A recently initiated, NHMRC-funded be a risk factor for the development of heart research project will set out to improve disease in women, but it has been felt that this diagnostic methodology for such patients, occurs via the associated obesity, insulin resist- evaluate the risk of peroxynitrite formation ance and diabetes. We have shown that young in the pathogenesis of the condition, women with polycystic ovary syndrome exhibit and determine whether there is actually abnormalities of platelet and blood vessel complete recovery from attacks. function (but not of endothelial progenitor cell production) irrespective of body weight. These Role of Thioredoxin/TXnip system in ongoing studies will seek to investigate the human disease (Prof J Horowitz, implications of therapy and the ageing process A/Prof J Kennedy, Dr D Ngo) on cardiac risk profile in this group of individ- We have recently demonstrated that uals. In particular, we will evaluate associations development of aortic stenosis in a rabbit between polycystic ovary syndrome, vascular model is associated with increased concen- and platelet function and endothelial progen- trations of the intracellular pro-oxidant itor cell counts in various subsets of patients. thioredoxin-interacting protein (TXnip). We are now evaluating the potential role of Non-pharmacological interventions in TXnip in other models of aortic stenosis and Heart Failure in other cardiovascular disease states. (Prof S Stewart, Prof J Horowitz) We have previously shown that outcomes Major Enabling Technologies: in patients with chronic heart failure can 1. Assay of asymmetric dimethylarginine be improved by screening them for short (ADMA). This assay, developed by Ms term deterioration during the early period Tamila Heresztyn, provides a marker of of time after discharge from hospital. The the function of the vascular endothelium.
TQEHresearch Research Report 2009 12 We recently reviewed the importance of this Staff “Utilising basic assay for all cardiac studies examining both Professor of Cardiology physiology and prognostic markers. Director, Cardiology Unit laboratory studies 2. Magnetic Resonance Imaging (MRI) of JD Horowitz MBBS BMedSc(Hons) PhD FRACP and clinical the Heart. In collaboration with TQEH cardiac magnetic Radiology Department we have developed Associate Professors a considerable cardiovascular MRI program JF Beltrame BSc BMBS FRACP PhD FESC FACC FCSANZ resonance imaging with over 1,000 studies performed. Increas- CJ Zeitz MBBS PhD FRACP OstJ techniques, ingly this technology is being utilised for our clinical research studies to identify Senior Clinical Staff important advances infarct size and perfusion abnormalities. O Akbar Ali MBBS FRACP FCSANZ have been made 3. Echocardiographic Backscatter. This M Arstall MBBS PhD FRACP at TQEH in technique, initially utilised for the quantita- P Averbuj MD FRACP tion of early aortic stenosis in a study from WP Chan MBBS FRACP understanding TQEH, is a vital tool in enabling us to follow CL Gibb MBBS FRACP the mechanisms the progression of aortic valve disease in both ADB Hains MBBS FRACP animal models and in the general population. JTY Hii BMBS FRACP responsible for this 4. Basic Vasomotor Studies. In collaboration SB Limaye MBBS MD MRCP FRACP disorder.” with TQEH Vascular Surgery and the Univer- D Lypourlis MD FRACP sity of Adelaide Physiology Department, we D Mahadevan BMBS FRACP have an extensive basic research program K Mishra MBBS MD MRCP FRACP to evaluate human vascular structure and C Neil MBBS FRACP function. This includes identification of D Ninio MBBS(Hons) FRACP calcium channels, isolated vessel reactivity A Philpott MBBS FRACP and vessel responses in a beating heart. S Rajendran MBBS PhD FRACP 5. Clinical Vasomotor Studies. To complement P Sage MBBS PhD FRACP these basic studies we have several clinical AL Sverdlov MBBS FRACP methodologies including endothelial function S Unger MBBS PhD FRACP testing, evaluation of coronary vasospastic AS Warner MBBS BMedSc(Hons) PhD FRACP responses, coronary Doppler wire and pressure wire studies. Senior Research Scientists 6. Endothelial Progenitor Cells Function. In YY Chirkov BSc PhD collaboration with the Renal Unit of TQEH, A Holmes BSc(Hons) PhD we are developing methods for quanti- JA Kennedy BSc(Hons) PhD tating the release from the bone marrow D Ngo BPharm BHlth Sc(Hons) PhD of endothelial progenitor cells, which play DP Wilson BSc(Hons) MSc PhD a major role in the ongoing repair of the vasculature. Disorders of endothelial progen- Laboratory Manager itor cell function postulated in association I Stafford BSc with most forms of cardiac disease and an additional therapeutic objective should be Research Assistants optimisation of EPC release. D Das MSc T Heresztyn BSc Collaborators (1) Department of Physiology, University of Technical Officer Adelaide G Murphy BA (2) Department of Medicine, St Vincent’s Hospital, Melbourne Trial Coordinators (3) Department of Epidemiology & Preventative C Anderson-Stanford RN Medicine, Monash University, Melbourne M Black RN (4) Cardiology Department, Birmingham J Rose RN University, UK T Selkow RN (5) Department of Obstetrics and Gynaecology, N Smith RN University of Adelaide (6) Baker Research Institute, Melbourne (7) Department of Biochemistry, University of Hannover, Germany
TQEHresearch Research Report 2009 13 Postgraduate Students
PhD Candidates P Averbuj MD FRACP “Pathophysiological interactions between diabetes and chronic kidney disease: implication for vascular events.” A Chan MBBS FRACP “The polycystic ovary syndrome and coronary risk” S Copley BSc(Hons) “The Role of RHO Kinase Inhibitors and Statins in the Coronary Slow Flow Phenomenon” N Cutri BSc(Hons) “The Characteristics of Microspastic Angina” R Dreyer BSc(Hons) “Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial infarction (AMI) – Patients. The VIRGO Study” N Ghaffari BSc(Hons) “The Modulation of Vasomotor Responses by Statin Therapy” E Goble RN BSc(Hons) MSc “Physiological determinants of outcome in heart failure” N Hurst MBBS FRACP FRCPA “The effect of the nitric oxide and prostacyclin pathways on platelet aggregation” L Jesuthasan MBBS FRACP “Coronary and myocardial perfusion studies of the coronary slow” V Kopetz BSc(Hons) “Biological determinants of the coronary slow flow phenomenon” G Mahadevan MBBS FRACP “The pathophysiology and potential therapeutics of diastolic heart failure” C Neil MBBS FRACP “Is the therapeutic induction of bradycardia beneficial in heart failure? Implications for cardiac contractility” A Philpott MBBS FRACP “Mechanisms and prevention of nitrate tolerance” K Rajopadhyaya BSc(Hons) “Molecular Physiology of Vascular Function” C Smith BSc(Hons) “Calcium T-Channel Distribution in the Human Vascular Tree and its Relation to Function” A Sverdlov MBBS FRACP “Pathogenesis of aortic sclerosis” R Tavella BSc(Hons) “Quality of life, depression and cardiac disease”
Honours Candidates D Calvanese BSc “The evaluation of cardiovascular health in chronic methampetamine users” Class IIA Honours Y Chan BSc “ET-1 vasoconstriction involves IP3, voltage-gated and soc channels” Class I Honours A Jaghoori BSc “Comparison of selective and dual endothelin blockade on Simvastatin effect on endothelin vasoconstrictor response” Class I Honours R Lindop BBiotech “Characterisation of Tissue Nitric Oxide Responsiveness in Patients with Bicuspid Aortic Valve” Class I Honours
Cardiology Department Vacation Scholarship 2009-2010 J Eng “Endothelin Antagonists and Statin Therapy - Is there a difference between selective Endothelin-A receptor antagonism and Combined Endothelin-A and B receptor antagonism?”
TQEHresearch Research Report 2009 14 Grants NHMRC. (Health Services Research Program BUPA Australia. The Clinical Utility of CT # 418967) Which Heart failure Intervention Coronary Angiography in the Assessment is most Cost-effective and consumer friendly of Patients with Intermediate Probability of in reducing Hospital care: The WHICH? Study. Coronary Artery Disease. ($100,000 2009) ($175,740 2009) 2008-2012, Stewart S, 2008-2010, Beltrame JF, Sebben R. Scuffham P, Marwick T, Horowitz JD, Krum H, Davidson P, Peter M, Reid C. Cardio Vascular Lipid Research Grant Pfizer Australia. Bicuspid aortic valve. ($55,000 NHMRC. (Project Grant) Tako-Tsubo cardio- 2009) Akbar Ali O. myopathy: pathogenesis and natural history. ($79,000 2009) 2009 – 2011, Horowitz JD, Department of Health Strategic Health Beltrame JF, Selvanayagam J, Frenneaux M, Research Program. Health, economic, Tsikas D. psychological and social benefits of educating carers. ($486,990 2009-2010) Rebecca L Cooper Medical Foundation. Phillips P, Jones T, Eckerman S, Worthley S, (Project Grant) Vitamin D deficiency and Beltrame JF, Chew D, Arstall MA, Cafarella P. endothelial dysfunction in people with diabetes. ($16,000 2009) 2009-2010, National Heart Foundation of Australia. Ngo DT. Endothelial dysfunction, redox stress and the pathogenesis of aortic valve calcifi- TQEH Research Foundation. (NHMRC Near cation. ($129,000 2009) 2008-2009, Miss grant 2008). The Rho Kinase pathway: Horowitz JD, Kennedy JA. A therapeutic target for micro vascular dysfunction. ($75,000 2009) Beltrame JF. National Heart Foundation of Australia. The prevalence of heart failure in Aboriginal TQEH Research Foundation. (NHMRC Near communities in Central Australia: The Heart Miss grant 2008) Determinants of progres- for the Heart Study (Stage 1). ($129,000 sion to aortic stenosis. ($35,000 2008-2009) 2009) 2008-2009, Brown A, Stewart S, Horowitz JD. Zeitz C, Krum H, Lee G, McGrady M, Carrington M. TQEH Research Foundation Strategic Initia- tives Funding. (Program grant) TQEH Vascular National Heart Foundation of Australia. Disease and Therapeutics Research Group: The Mevalonate and Rho kinase Pathways: towards improved outcomes for vascular Combination Therapy Targeted at the disease. ($180,000 2009) 2009-2011, Treatment of Microvascular Dysfunction. Horowitz JD, Beltrame JF, Morris RG, Fitridge ($123,000 2009) 2009-2010, Wilson DP, RA, Zeitz CJ, Wilson DP, Sallustio BC, Chirkov Beltrame JF, Horowitz JD. YY, Kennedy JA, Cowled PA.
National Heart Foundation of Australia. TQEH Research Foundation. (Small grant (Grant in Aid G07A3109) The early use 2008) IVANA study continuation funding. of N-AcetylCysteine in Acute Myocardial ($12,000 2009) Beltrame JF. Infarction. (The NACIAM Study) ($64,500 2009) 2008-2009, Beltrame JF, Arstall MA, TQEH Research Foundation. (Small grant Selvanayagam J, Horowitz JD. 2009) Clinical and Biological Determinants of the Coronary Slow Flow Phenomenon. National Heart Foundation (South Australia). ($6,000 2009) Beltrame JF, Heresztyn T. (J-Trust Fund) Vascular studies using a Laser Doppler Surface Blood Flow Monitor. TQEH Research Foundation. (Small grant ($15,000 2009) 2009-2010, Beltrame JF. 2009) Hyperglycaemia attenuates p53 function in the endothelium. Implications for NHMRC. (Project grant #472642) Novel impaired vasodilator function in diabetes. cGMP-Based Therapies Prevent Left ($10,412 2009) Holmes A, Kennedy JA. Ventricular Remodelling. ($197,250 2009) 2008-2010, Ritchie RH, Horowitz JD, TQEH Research Foundation. Top Up Kemp-Harper BH. Postgraduate Scholarships ($7,083 2009) Neil C, Averbuj P.
TQEHresearch Research Report 2009 15 TQEH Research Foundation. Honours Research Scholarships ($8,000 2009) Chan Y, Lindop R.
New grants awarded for 2010 National Heart Foundation/SA Department of Health (ID# CR 09A 4249). (South Australian Cardio Vascular Research Development Program Fellowship) Endothelin as a Therapeutic Target in Ischaemic Vascular Disorders. ($450,000 2010-2012) Beltrame JF.
NHMRC. (Project grant # 627245) Determinants of occurrence and progression of aortic stenosis in bicuspid and tricuspid valves. ($526,875 2010-2012) Horowitz JD.
Awards K Rajopadhyaya. The Queen Elizabeth Hospital Research Foundation Award for Best Junior PhD Student Presentation, The Queen Elizabeth Hospital Research Day, Adelaide October 2009.
Acknowledgements The Cardiology Unit wishes to thank the Anne-Marie Trimboli Trust, the NHF, NHMRC, The Queen Elizabeth Hospital Research Foundation, Rebecca L Cooper Foundation, South Australian Department of Health and the University of Adelaide for their valuable project, research staff and student support.
TQEHresearch Research Report 2009 16 TQEHresearch Research Report 2009 17 Clinical Pharmacology Unit
Overview Research Focus: The laboratory relocated in July 2009 into The Basil • Translating laboratory skills in therapeutic Hetzel Institute (BHI), thereby forging more physical links drug monitoring to the delivery of with the laboratory-based research community at TQEH optimal testing for clinical care and beyond. To say that this relocation from the main • Perhexiline genetics and metabolism hospital building was a breath of fresh air would be an understatement. What a wonderful facility we have • Studies involving the drugs used in organ for established research staff and for nurturing aspiring transplantation to avert rejection young researchers. • Local anaesthetic drugs in post-operative The focus this year continues established programs, pain management and fast-track surgery often closely allied to our routine diagnostic drug-assay analytical work in patient care, but also unrelated pharmacological studies where the focus is delivery of translational outcomes that enhance medical care in our community. Our group has formal links in 2 of the new TQEH Research Foundation funded program grants, being the Renal Program Grant, and the Vascular Disease and Therapeutics Research Group.
A particular research highlight in 2009 has been the PhD awarded to Dr Ian Westley. This candidature has been a great pleasure to observe. Ian started in our labora- tory as a Technical Officer, and then in recent years was promoted to Senior Medical Scientist. He initially enrolled in external part-time studies to gain his Science degree, then enrolled in a Masters and upgraded to a Doctorate (PhD). His project involved the complexities of the transplantation drug, mycophenolate, and the way various cellular transporters in liver cells handle this drug, including competitive effects of co-administered drugs also used in transplantation, and various rodent models. Associate Professor These drug-handling issues make clinical management of Ray Morris our renal transplant patients taking this drug complex. Ian was given leave-of-absence to do post-doctoral work with a prestigious group in Belgium for 12 months, returning to TQEH/BHI in September. In this role, Ian developed the method and implemented the national plasma concentrations monitoring of the anti-cancer drug Imatinib in Belgium.
TQEHresearch Research Report 2009 18 Angina treatment clinical, biochemical and genetic data to The department maintains an active establish whether it may be possible to research interest in the treatment of angina, further reduce rejection and loss of the particularly in patients receiving perhex- transplanted organ by individualising each iline, an older and very effective drug patient’s immunosuppressant medication which can, however, cause serious liver and based on their genetics and the genetics of nerve toxicity if dosages are not individual- the transplanted organ. ised based on the testing provided in our lab. Our current research aims to better As alluded to above, the PhD study into understand the mechanisms of action and the cellular mechanisms by which the liver fate of perhexiline in the body in order handles mycophenolate and other drugs to translate this understanding into safer given to transplant recipients has now been clinical use, and to develop new therapies completed. Dr Ian Westley has identified for the treatment of angina. The project is the MRP2 liver transporter protein involved currently supported by a PhD student, Mr in the elimination of mycophenolate and its John Licari, whose work is investigating metabolites from the body, and in addition, the development of new drugs for the has generated evidence that mutations treatment of angina, based on our growing of MRP2 may affect an individual’s risk of knowledge of how perhexiline works. John developing kidney damage. has identified two chemicals, similar to the current perhexiline medication and has Local anaesthesia and ‘fast-track’ surgery completed testing their safety in animal This project involves a PhD candidature of models. He has shown that whilst one Ms Sumi Krishnan, and studies the potential chemical is very similar to perhexiline and to reduce or eliminate the use of narcotic causes both liver and nerve damage, the analgesics for pain relief following either other appears to have a much better safety laparoscopic or open abdominal surgery by profile. Testing is currently underway to slowly trickling in local anaesthetic dorsal to determine whether this new drug is also the surgical incision site for 4 days following effective in treating angina and other forms surgery using a commercial device called of heart disease. Some of John’s work was PainBuster®. The recruitment phase of this presented in October at the North American clinical trial (80 patients) was completed meeting of the International Society for the in late 2009. The work remaining includes Study of Xenobiotics. the statistical analysis of a large amount of clinical and laboratory data, further labora- Transplantation therapy tory work in the understanding of the Our laboratory is part of a SA/NT team handling of the infused local anaesthetic involved in a long-term strategy to provide drug, including the changes that occur pancreatic islet cell transplantation for the to protein binding of the drug following treatment of type-1 diabetes. Specifically, the ‘stress’ of surgery. This project also our role is to provide the national drug forms part of a ‘fast-track surgery’ protocol monitoring service in the national consor- that is aimed at a win-win for the patient tium. We acknowledge the hard work of and health-care system by enhancing the Juvenile Diabetes Research Foundation recovery post-surgery thereby allowing (JDRF) in making this funding available. earlier discharge and reducing length of hospitalisation. The portable PainBuster® Clinical Pharmacology received major device allows freedom of movement of funding for 2009-2011 from the National the recovering patients, so avoiding the Health and Medical Research Council to confinement to a bed and connections to support a research scientist, Mr Ben Noll, intravenous catheters and infusion pumps. who is assisting in a wide-ranging project This work is exciting in that our research can investigating overall genetic factors that translate into direct benefits to patients in may influence the efficacy of immunosup- this way. pressant drugs and, hence, the incidence of rejection or organ toxicity. The project aims to recruit 200 kidney transplant recipients and their donors, and we are half way to our target of collecting sufficient
TQEHresearch Research Report 2009 19 Staff Completed thesis Chief Medical Scientist IS Westley BMedLabSc PhD, University of South Australia, School of RG Morris BSc PhD Pharmacy and Medical Sciences, 2009. Thesis: “Investigation of the interindividual Principal Medical Scientist variability in the disposition of BC Sallustio BSc PhD mycophenolic acid and its ether and acyl Senior Medical Scientist glucuronide metabolites: metabolic and IS Westley BMedSc PhD transporter effects” R Bright BSc(Hons) Postgraduate Students Grant-Funded Scientist B Noll BSc(Hons) PhD Candidates J Licari BHSc(Hons) “Investigation of the pharmacological effect Technical Officers of (-)- and (+)-perhexiline” FA Wicks BSc S Krishnan BHlthSc(Hons) “The clinical evaluation of fast-track surgery A Kalaitsidis BSc C Lang-Jones Cert Med Lab Sc including extended local anaesthetic infusion D Dinow BSc for post-operative pain”
Administrative Officer Honours Candidate J Borosewicz BSc Z MD Dom BHlthSc “Metabolism of mycophenolic acid in human P Cardone liver microsomes: effect of tacrolimus, cyclosporine and its metabolites”
Grants Juvenile Diabetes Research Foundation. (Program grant) South Australian and Northern Territory Pancreatic Islet Isolation Program (SANTIP) ($851,728 2008-2009) 2006 – 2009, Russ GR, Coates PTH, Morris RG, Sallustio BC, and all other members of SANTIP.
NHMRC. (Project grant) Pharmacogenomics of Renal Transplantation ($114,750 2009) 2009-2011, Sallustio BC, Coller JK, Morris RG, Somogyi AA.
Surgical Synergies. Product support for patient local anaesthesia studies (approx $70,000 2009), Morris RG, Hewett P, Karatassas A, Tonkin J.
TQEH Research Foundation Strategic Initiatives Funding. (Program grant) South Australian Translational Centre for Renal Research ($180,000 2009) 2009-2011, Russ GR, PT Coates, S McDonald, Sallustio BC, Morris RG.
TQEH Research Foundation Strategic Initiatives Funding. (Program grant) Vascular Diseases and Therapeutics Research Group: Towards improved outcomes for Vascular Disease ($180,000 2009) 2009-2011, Horowitz JD, Beltrame JF, Morris RG, Fitridge RA, Zeitz CJ, Wilson DP, Sallustio BC, Chirkov YY, Kennedy JA, Cowled PA.
TQEH Research Foundation/University of Adelaide Faculty of Health Sciences Divisional Postgraduate Scholarships ($40,854 2009) 2007-2009 Licari J, Krishnan S.
TQEH Research Foundation Honours Research Scholarship ($4,000 2009). MD Dom, Z.
TQEHresearch Research Report 2009 20 DERMATOLOGY UNIT Research Focus
• Clinical trials of new treatments to reduce actinic keratoses and skin cancers in renal transplant patients Dr Warren Weightman
Overview doing safety skin assessments. The trial is “The unit is also The Dermatology Unit assesses and treats a 24 month, double-blind, randomized, involved in clinical skin disorders at The Queen Elizabeth multi-centre, placebo-controlled, parallel- Hospital (TQEH) in both outpatients and group study comparing efficacy and safety research with inpatients and teaches medical students, of FTY720 1.25mg and 0.5mg administered an emphasis on dermatology registrars, general practitioners orally once daily versus placebo in patients and other doctors employed at TQEH. The with relapsing-remitting multiple sclerosis. different methods unit is also involved in clinical research of treatment and with an emphasis on different methods of The third study is a multicentre, randomized, prevention of sun treatment and prevention of sun damage double-blind, placebo-controlled, phase II and skin cancer. Dr Warren Weightman is a study to evaluate the safety and efficacy of damage and skin board member of the Australian Society of subcutaneous bioresorbable implants of cancer.” Dermatological Research. CUV1647 for the prophylactic treatment of pre-cancerous skin lesions of the head, We have been involved in five studies during forearms and hands in immune compro- 2009. mised, organ transplant patients.
The first study is in association with the The fourth study is a clinical trial looking at Renal Unit of TQEH. This is a 12 month the efficacy and safety of 5% 5-fluorouracil open-label, randomized, multi-centre, cream in renal transplant patients for the sequential cohort, dose finding study to treatment of actinic keratoses. evaluate the efficacy, safety and tolerability of oral AEB071 versus Neoral in combina- The fifth study is a clinical study looking at tion with Certican, Simulect and corticos- the presence and type of pain in Squamous teroids in de novo adult renal transplant Cell Cancers in renal transplant patients. recipients. The dermatology unit is doing the safety skin assessments. The unit is looking at doing further clinical trials in the future. The second study is in association with the Neurology Unit with the Dermatology Unit
Staff Head of Department W Weightman MBBS FRACP FACD
Visiting Dermatologists P Selva MBBS FACD A Lewis MBBS FRACGP FACD YC Lee MBBS FACD
Dermatology Registrar E Haverhock MBBS
TQEHresearch Research Report 2009 21 ENDOCRINOLOGY UNIT Research Focus • Health care delivery • Development of efficient strategies to diagnose and monitor diabetes and osteoporosis Dr Pat Phillips
“The research is Overview for risk factors and early indicators of chronic Translational research is our major research health problems, especially diabetes and to identify the focus. Our work has been concentrated on cardiovascular and respiratory disease. The achievement of the health care delivery and the develop- original cohort was first assessed in 2000 and important diabetes ment of efficient strategies to diagnose and has been reassessed twice with an interval of monitor diabetes and osteoporosis, with the about 3 years to give longitudinal information management emphasis on directly dealing with compli- on health status. We have used this dataset to targets, the cated patient issues and improving the level assess the diabetes incidence, self and health of local general practitioners (GPs) and other system based management and changes of uptake of health care professionals in regular chronic diabetes incidence/management, and finally guidelines for diseases management through evidence- the risk factors associated with aspects. diabetes based feedback. Support for our research has come from a wide range of government and A comparative study is also underway to management, private organisations. assess the comparability of diabetes patients the development in this population sample and the patient Clinically we continue to use the diabetes cohort in DAC dataset. The objective is to of diabetes patient dataset established since 1998 establish a patient base for studying the complications and for research on the status of people who continuum of diabetes patient progress attend the unit’s Diabetes Assessment Clinic from early diagnosis to the late stage with strategies that are (DAC). DAC provides patients referred by full development of complications requiring effective in their GPs a “one stop shop” which includes hospital care. The psychological data of DAC improving care checking for predisposition to diabetes, risk patients is also assessed to be compared with factors for complications, the complications the similar data in the population sample to and reducing themselves and current therapy. The research explore the mental status of diabetes patients complications.” is to identify the achievement of important at different stage. diabetes management targets, the uptake of guidelines for diabetes management, the Alongside the quantitative data we also development of diabetes complications and participate in studies assessing qualitative strategies that are effective in improving information including quality of life and the care and reducing complications. One key individual responses to changes in health feature of our work is the established link status. These studies will give us data on the and feedback mechanism to GPs referring factors associated with improved, stable or their patients for both outpatient care and worsening health status and ideas on how DAC care. This enables us to evaluate strate- medical, self care and quality of life can be gies to prompt/improve diabetes manage- improved. The expansion of the study to ment by GPs. If successful, we will broaden cover Whyalla area and to include a cohort the audience for these prompts on diabetes of children is also underway. These will give care and the areas they cover. The format us insight into the chronic health status of and content of the feedback to GPs has been country SA and children. updated based on current research develop- ment in diabetes management in 2009. The president of the Henan Wujin General Hospital, China, visited the Endocrinology Unit In 2009 we continued the North West and TQEH. The hospital has expressed a wish Adelaide Health Study in collaboration with to collaborate with the unit in developing other departments in The Queen Elizabeth diabetes treatment strategies to combat Hospital, the Unit of Population Research & the growing epidemic of diabetes in their Outcome Studies of the Department of Health province. Unit staff have been invited to give and the University of South Australia. The lectures in Henan Wujin General Hospital study population is a representative sample in 2010. It was also agreed that some of residents in North West Adelaide, checking doctors and researchers will be visiting and
TQEHresearch Research Report 2009 22 conducting short term research in TQEH in the Staff “Osteoporosis and next few years. Director associated fractures PJ Phillips MBBS MA MRACMA FRACP Osteoporosis and associated fractures are Grad Dip Hlth Econ are a major cause of a major cause of preventable disability and preventable disability dependence for South Australians and a Medical Specialists major cost to the community. Our good N Laddipeerla MBBS MD DNB (Endo) and dependence for links with the community organisation CG Beng MBBS MRC PATH MAACB Associate South Australians Osteoporosis Australia, the Royal Australian Physician (Clin Chemistry Dept) College of General Practitioners and the and a major cost to Divisions of General Practice enable us to Scientists the community.” review the management of osteoporosis in J Wang BSc MPH PhD the community. There are now osteoporosis C Seaborn BSc education and awareness programmes in E Bowen BSc the western and northern metropolitan areas targeting those with osteoporosis, their health Ophthalmology professionals and the general community. N Gehling BSc BMBS FRACO M Goggin MB BCh BAO DO FRCSI (Ophth) We now have two dual Xray absorptiom- FRCOPhth PhD eter (DXA) scanners (at the Lyell McEwin J Runciman MB BHB FRACS FRACO and at The Queen Elizabeth Hospital). These A Drew CRA (US) meet the needs of the northern and western suburbs of Adelaide and associated country Diabetes Centre Nurses areas. Our combined services now see about T Willson RN BN(Hons) Grad Cert Health 5,500 patients per year and we have a (Diab Man and Ed) CDE database containing records for over 26,000 R Cox CN BN MN individuals. A large proportion of these are M Hodgson RN RM BMid Grad Cert (Diab Ed) being monitored for changes in bone density D Barrow RN Grad Cert (Diab Ed) over time. This important source of clinical C Nitschke RN RM Grad Cert (Diab Man & Ed) “We are working date provides the opportunity of investigating R Wilson CN many aspects of the overall bone health of R Gunadi BMgt BN MN RN DRN with Osteoporosis the communities that we service, and of long Australia to make term trends and changes. With the addition Podiatry Service osteoporosis a State of a specialist epidemiologist/statistician D Brown DipAppSc Nursing BAppSc Podiatry to our ranks, we are now in a position to D Filipak BAppSc Podiatry health priority and to undertake an assessment of this database develop a strategic with a view to publication. Dietitians M Campbell MNutrDiet plan to reduce its We are working with Osteoporosis Australia to C Stanton BSc DipEd MNutrDiet impact in South make osteoporosis a State health priority and to M Campbell MNutrDiet develop a strategic plan to reduce its impact in Australia.” South Australia. We have been working with the Diabetes Outreach Florey Adelaide Male Aging Study to measure J Giles Grad Cert(Diab Ed) MN (Advanced Prac) CDE bone density and body composition in a cohort K Visentin of men selected from the northern and western C Gilbert BA(Hons) regions of Adelaide. This is a longitudinal study S Westlake and is now in its seventh year. Participants are followed up every five years. This study Administration offers the opportunity to assess and analyse L Roberts changes in both bone density and regional body C Bouthémy DipHlthSc composition as men age and we are currently J Grimsey accumulating data for future analysis. During A Gazzard 2009, a further cohort of follow up participants V Watson has been assessed and added to the database. J Cocks We will review this database during 2010 and B Cummins assess the results for potential publication. L Clark
TQEHresearch Research Report 2009 23 GASTROENTEROLOGY AND HEPATOLOGY UNIT
Research Focus • Intestinal growth and intestinal stem cells • Coeliac disease Professor • Pathogenesis of bowel inflammation Ian Roberts-Thomson
“The study Overview they are thought to be important as they Dr Adrian Cummins has completed the will investigate are long-lived, accumulate mutations and second year of his NHMRC project on the have metastatic potential. The study will whether abnormal regulation of intestinal stem cells during investigate whether abnormal stem cells can stem cells can be growth of the small intestine. Rino Donato be detected in the blood of patients who is the Research Assistant and Joshua Woenig have had a bowel resection for cancer and detected in the is the Technical Officer on this project. whether this predicts recurrence of cancer. blood of patients The aim of this work is to identify growth These findings could be used to select a factors that might be used to treat disorders group of patients for further treatment with who have had a such as short bowel syndrome both in chemotherapy. bowel resection children and in adults. The study is concen- trating on the Wnt/beta catenin and Notch for cancer and Dr Ilmars Lidums and Dr Adrian Cummins signalling pathways. Of 19 possible Wnt completed a study of the use of the whether this growth factors, at least two appear to be PillCam capsule to assess the extent of predicts recurrence important in intestinal growth in rats. We bowel inflammation in patients with were fortunate to obtain TQEH Research coeliac disease, both before and after of cancer.” Foundation funding of $160,000 for a laser treatment with a gluten-free diet. In a microdissection microscope for The Research second study, capsule endoscopy was used Institute to assist in this and other projects. to assess bowel inflammation in patients This enables us to isolate the area around with positive coeliac serology but normal intestinal stem cells in a tissue section to duodenal biopsies. These studies were determine cell markers and local growth presented by Dr Lidums at the Australian factors. In order to translate this knowledge Gastroenterology Week in Sydney in directly to humans, collaboration continues October. Additional work related to coeliac with Dr David Moore, Dr Richard Couper disease is also being performed by Dr Guy and Dr Paul Hammond from the Centre for Sander with help from Ms A Chua. Other Adolescent and Paediatric Gastroenterology collaborative studies involve Associate at the Women’s and Children’s Hospital. Professor Irmeli Penttila at the Women’s and Children’s Health Research Institute and A second line of investigation concerns Associate Professor Gordon Howarth from abnormal intestinal stem cells in colorectal the Roseworthy Campus of the University cancer. Dr Cummins and Professor Ian of Adelaide. These collaborative projects Roberts-Thomson from this Department and involve the development of food allergy Dr Jenny Hardingham from the Department and the effect of probiotics on ameliorating of Haematology/Oncology were awarded inflammatory bowel disease in animal a joint grant from the Cancer Council of models. Dr Adrian Cummins was awarded South Australia. To assist in this project, the title of Clinical Associate Professor from Dr Phulwinder (Kumar) Grover has come the University of Adelaide during 2009. to our Department from Flinders Medical Nicola Eastaff-Leung was awarded a PhD for Centre after completing a NIH grant. He her thesis on regulatory and Th17 T cells in has 25 years experience in research mainly inflammatory bowel disease. Rino Donato in the field of kidney stones but is changing was also awarded a PhD based on work his focus to cancer research. Dr Cummins, done at Women’s and Children’s Health Dr Grover and Dr Hardingham were Research Institute. fortunate to receive a further small grant of $10,000 from TQEH Research Founda- tion to work on a particular marker of stem cells (OLFM4) in colorectal cancer as part of this larger study. Cancer stem cells may only make up 1% of cancer cells but
TQEHresearch Research Report 2009 24 Staff Director IC Roberts-Thomson MD FRACP
Senior Consultant AG Cummins BSc(Med) MD PhD FRACP I Lidums PhD FRACP
Post-doctoral Fellow G Sander BSc (Hons) PhD PK Grover PhD
Medical Scientist WJ Uylaki BSc(Hons)
Technical Officers J Woenig BSc
Research Assistant R Donato BSc(Hons)
Completed thesis N Eastaff-Leung PhD, University of Adelaide, Department of Medicine, 2009. Thesis: “Deficiency of immunoregulatory cells in Inflammatory bowel disease”.
PhD Candidates J Fauser BSc(Hons) “The effect of probiotics on the small intestine” L Prisciandaro “Novel probiotic supernatants and treatment of gastrointestinal BSc Animal Sci (Hons) disorders”
Grants intestinal stem cell marker in health and NHMRC. (Project grant) The role of intestinal disease. ($101,000 2009) Cummins AG, epithelium in gliadin peptide influx in celiac Roberts-Thomson I, Hardingham J, disease. ($161,000 2009) 2008-1010, Gibson R. Sander G. TQEH Research Foundation. (BHI facility NHMRC. (Project grant) Regulation of Equipment grant) Laser dissection intestinal stem cells and intestinal growth. microscope. ($160,000 2009) Cummins AG, ($135,000 2009) 2008-1010, Cummins AG, Hardingham J. Pentilla I. TQEH Research Foundation. (Small grant NHMRC. (Complimentary Medicine Project 2009) Investigation of OLFMG positive stem grant). Novel probiotics and naturally cells in colorectal cancer. ($10,000 2009) sourced extracts as treatment strategies for Cummins AG, Grover PK, Hardingham J, chemotherapy-induced intestinal mucositis. Price T. ($107,000 2009) 2008-2010, Howarth G, Butler R, Cummins AG. University of Adelaide School of Animal and Veterinary Sciences Divisional Scholar- The Cancer Council of South Australia. ship/Pork CRC Top Up Scholarship ($25,427 (Project grant) Investigation of Lgr as an 2009) Fauser J.
TQEHresearch Research Report 2009 25 GYNAECOLOGY, Department of Research Focus • Pelvic organ prolapse • Essure sterilisation procedure • Pelvic cancer Dr Roy Watson
Overview randomised trial of vaginal mesh repair for The Gynaecology department provides a the correction of cystocele (MAP study). Dr comprehensive range of general gynaeco- Paul Duggan at the Royal Adelaide Hospital logical and subspecialist investigations is the principal investigator. and procedures with an emphasis on minimally invasive surgery, colposcopy, pelvic Dr Monika Juneja, recently appointed as organ prolapse and urinary incontinence VMS in Gynaecology, is investigating the (urogynaecology), gynaecological oncology role of hysterectomy in prolapse repair and management of severe endometriosis with a seeding grant from the Australian including close collaboration with our Gynaecological Endoscopy Society Research colorectal colleagues for severe pelvic disease. Committee. Her term supervisors are Drs All consultants in our department have an Barry and Munday. active role in clinical research activities and are supportive of our trainees undertaking The POPPY study is an international collabo- suitable projects while working in our unit. rative multi centre randomised study to In 2009 the department continued to build investigate the use of pelvic floor muscle personnel and funds to support future large strengthening for female pelvic organ trials particularly in the area of pelvic organ prolapse. Dr Barry is TQEH’s researcher in “All consultants in prolapse and related minimally invasive this study. Dr Barry is also trialling the use of surgical treatments, including mesh vaginal herbal preparation R1962 for the reduction our department repair; Essure sterilisation and gynaecological in recurrence of urinary tract infections in have an active oncology. However, Dr Chris Barry continues women. to promote a more diverse interest in pelvic role in clinical floor disorders with interest in natural Dr Munday and Dr Jane Fielder (Senior research activities remedies and molecular mechanisms related Registrar) have commenced a study to bladder inflammatory disorders. comparing various imaging techniques and are supportive following the Essure female sterilisation of our trainees Research interests include final assessment procedure. undertaking of vaginal mesh repair trials into uterine conservation; new approaches to imaging suitable projects pelvic organ prolapse and novel treatments while working in for interstitial cystitis.
our unit.” Dr John Miller, Senior Visiting Gynaecological Oncologist, has involved our department in multicentre investigations with the University of Adelaide into the psychological aspects of recurrent cancer and the development of patient decision aids as well as continuing to recruit patients for chemotherapy and surgical trials centred at the Royal Adelaide Hospital.
Dr Amita Singla has commenced a trial examining the effectiveness of women self-collecting Pap smears aimed at improving compliance.
Drs Barry and Munday are coordinating the hospital’s arm of a multi-centre prospective
TQEHresearch Research Report 2009 26 Staff J Miller MB BS FRANZCOG CGO Director Senior Visiting Gynaecologist and certified R Watson MBBS FRANZCOG FRCOG sub-specialist in Gynaecology Oncology. Senior Visiting Gynaecologist with specialist interest in pre malignant disease, Tutor and A Singla MB BS FRANZCOG Assessor for the RANZCOG Chair of RANZCOG Senior Staff Specialist, Senior Obstetrician Asia Pacific Committee and DRANZCOG and Gynaecologist with special interest in Education and Assessment Committee. Pelvic Floor repair, menopause, Colposcopy and vulval disorders. Senior Consultants C Barry MB BS MRCOG FRANZCOG D Roberts MBBS FRANZCOG Staff Specialist and Senior Gynaecologist Visiting Medical Specialist, Obstetrician and with a special interest in Urogynaecology. Gynaecologist. President of the SA Continence Foundation of Australia. Dr M Juneja MB BS FRANZCOG Visiting Medical Specialist in Gynaecology. D Munday MB BS FRANZCOG Senior Visiting Gynaecologist with special Gynaecology Clinical Practice interests in minimal access surgery/ Consultant endometriosis/pelvic floor repair/Essure S O’Toole sterilisation. Deputy Chair of the Australian Gynaecological Endoscopy Society Research Acting Gynaecology Clinical Practice Committee. Consultants (2009) V Filipatos A Matthew
TQEHresearch Research Report 2009 27 HAEMATOLOGY AND MEDICAL ONCOLOGY, The combined Departments of Research Focus • Identification, development and clinical trial of new therapeutic agents for the treatment of cancer • Further understanding of the mechanisms underlying solid cancers and haematological disease, particularly myeloproliferative disorders and leukaemia Associate Professor • Development of new cancer diagnostic assays Peter Bardy
“The focus of Clinical research improvement projects to optimise the The clinical trial program involves Phase I, II management of pre-operative anaemia and activity in relation and III trials of new therapeutics. Ongoing reduce transfusion rates in orthopaedic and to transfusion and studies are investigating chemotherapeutic colorectal surgery. anaemia involves agents, new supportive therapies (cytokines, erythropoietic agents), novel molecular At a national level, Dr Kathryn Robinson clinical practice targeted agents (EGFR, VEGF and mTOR coordinated the first meeting of an Iron improvement inhibitors) and antithrombotic agents. Deficiency Anaemia Expert Group to help Currently there are over thirty active clinical to identify barriers to improvement, future projects to optimise trials available to patients within the unit. research directions and national priorities. the management These include investigator driven, coopera- The group currently has a review article of pre-operative tive group and pharmaceutical driven Phase on iron deficiency anaemia underway for I to Phase III studies. Over 15% of patients submission to the MJA. A/Prof Peter Bardy anaemia and are ultimately entered in clinical trials well and Dr Kathryn Robinson have also been reduce transfusion above the recommended 10% target. The unit involved in a randomised controlled trial consists of Medical Oncologists, Haematolo- of oral iron replacement in female blood rates in orthopaedic gists, eight Clinical Trials Co-ordinators and a donors conducted by the Australian Red and colorectal dedicated Clinical Research Fellow. Trial results Cross Blood Service. from our unit have been presented by our surgery.” team at this years American Society of Clinical A/Prof Peter Bardy, through his links with Oncology, ESMO and NCI-EORTC Meeting the Tissue Typing Laboratory, has been and include work with anti-angiogenic collaborating with the Renal Unit to therapy combined with chemotherapy and optimize the management of sensitized Phase I results of NPI-0052, a novel protea- patients having renal transplants. some inhibitor. In addition, collaboration with the Basil Hetzel institute has allowed clinical trial tissue banks to be used with the aim to Laboratory-based studies explore the EGFR pathway in correlation with Project 1: Molecular-genetic approaches clinical outcomes. to identify lesions in myeloproliferative neoplasms (A/Prof R D’Andrea, A/Prof P The unit also has a special interest in Bardy, Dr P Neufing, Ms C Butcher) non-malignant haematology including thrombosis and haemostasis (Dr Simon We have focused on the myeloproliferative McRae) and transfusion, anaemia, iron neoplasm (MPN) Polycythemia Vera (PV), a deficiency and blood conservation (Dr hematological disease in which the bone Kathryn Robinson, Dr Uwe Hahn & A/Prof marrow produces increased numbers of Peter Bardy). several haemopoietic cell types (red blood cells, white blood cells and platelets). This The focus in thrombosis management is disease is of particular interest to us as the the use of new anticoagulants. This work multilineage effects are associated with a involves company sponsored as well as dysregulation of haemopoietic stem cell investigator-led trials. growth and normal blood cell growth factor responses. An acquired mutation is The focus of activity in relation to transfu- present in a high percentage of PV patients. sion and anaemia involves clinical practice
TQEHresearch Research Report 2009 28 This mutation affects the activity of the characterizing a novel mutation present intracellular signaling molecule JAK2 which in three families, including a large South plays a critical role in normal growth factor Australian family. responses. Whilst the JAK2 mutation is clearly important, several studies indicate additional genetic events are involved in Project 3: MAX Translational Sub-study: the initiation and progression of MPN. Determination of biomarkers to predict We have identified the gene RUNX1 as a resistance or sensitivity to anti-angiogenic likely candidate for involvement in PV and monoclonal antibody therapy in colorectal have screened this gene for mutations in cancer (Dr J Hardingham, A/Prof T Price, a number of PV patients. We have identi- Dr A Townsend) fied a RUNX1 mutation in a PV patient who Recent developments in the use of novel developed leukaemia. This is the subject of a targeted therapies to treat colorectal cancer, manuscript currently in preparation. such as monoclonal antibody therapy (bevacizumab) inhibiting the vascular We are also using several genome-wide endothelial growth factor (VEGF), offer “We are now approaches to identify other genes that promise in improving patient outcomes. may be involved in initiation or progression The identification of biomarkers that predict characterizing a of disease. In collaboration with Dr Charles which patients will benefit from such novel mutation Mulligan (St Jude’s Research Institute, therapy can significantly aid in tailoring present in three Memphis, USA) we are presently conducting treatment for each patient to improve a Single Nucleotide Polymorphism (SNP) efficacy and reduce the toxicity and cost families, including array comparing paired affected and of treatment. Activation of the EGFR in a large South unaffected tissue from PV patients to colorectal cancer results in cell signalling identify altered chromosomal regions. via several pathways including the PI3K/AKT Australian family.“ From these regions we have prioritised and and RAS/MEK/ERK pathways, which regulate screened several genes for mutations in cell proliferation, survival and importantly, PV patients. We are currently screening a production of angiogenic factors. There is cohort of normal individuals to investigate a complex interaction between the EGFR the significance of mutations detected in signalling pathways and tumour angiogen- PV patients. esis. EGFR activation results in the phospho- activation of downstream molecules and increased production of multiple angiogenic Project 2: Australian Familial factors including VEGF and interleukin 8. Hematological Cancer Study (AFHCS) Given the effect of constitutive activation of (A/Prof R D’Andrea, A/Prof P Bardy) the EGFR signalling pathways on prognosis, Studies of families showing single gene and the effect of mutant KRAS/BRAF and inheritance for predisposition to hemato- loss of PTEN on the induction of VEGF and logical malignancies will facilitate the other angiogenic factors, the aim is to identification of the genes and mechanisms investigate the association of mutant KRAS/ involved in the first steps of these cancers. BRAF and loss of PTEN on the response to This has been a successful approach to bevacizumab. We also aim to investigate the identification of genes implicated in the relationship between the activation of solid tissue cancers. In collaboration with the downstream molecules AKT, IL-8 and Prof Hamish Scott and Dr Graeme Suthers HIF-1, and the response to bevacizumab. We we have identified a number of South have analysed 148 samples to date for KRAS Australian kindreds with familial hemato- mutations using high resolution melting logical malignancy, recorded pedigree (HRM) and found 55/148 (37%) mutant. We data, collected clinical and demographic have also developed a highly sensitive novel data about family members, and stored technique to detect BRAF mutations using biological samples (blood, tissue) from both HRM and a discriminatory probe. Sample affected and unaffected family members. testing and validation by sequencing is Having identified these families of interest, underway. and excluded the involvement of known predisposition genes, we are now using sophisticated genetic approaches to identify new genes underlying the early events in hematological malignancy. We are now
TQEHresearch Research Report 2009 29 Project 4: Discovery of biomarkers for Project 5: Detection of occult dissemi- diagnostic and therapeutic applications in nated tumour cells and tumour DNA colorectal cancer (Dr M Raynor, A/Prof K Pittman) (Dr J Hardingham, Prof P Hewett) We are studying the significance of Patients diagnosed with early stage circulating tumour cells in patients with colorectal cancer (TNM stage I or II) undergo early stage operable breast cancer and surgical tumour resection with curative monitoring the presence of occult disease intent, yet up to 30% of these patients (circulating tumour cells and tumour DNA suffer recurrent or metastatic disease within in the plasma) at regular intervals after five years of surgery. This suggests that surgery. To isolate circulating tumour cells an occult metastatic disease process was we make extensive use of the Immunobead already under-way, or that viable tumour RT-PCR method, which was previously cells with proliferative and metastatic established in this department. In addition, potential had been shed from the primary plasma is separated from the blood samples tumour site during surgical resection. We for the detection of tumour DNA using “The presence have shown by immunobead RT-PCR that methylation markers. The immunobead of high levels of circulating tumour cells (CTC) detected at RT-PCR method has now been adapted diagnosis using a panel of five biomarkers for a high-throughput platform to allow PCK8 is thought predict later relapse. However the test quantitation, faster processing of samples to protect the cells showed only 80% specificity. Our aim is to and clear distinction between specific and discover better tumour biomarkers for colon background amplification. Ten experimental from apoptosis (cell tumour cells. To this end we have investi- gene markers and three housekeeping gene death) and this may gated the molecule SET and found it to be markers have now been fully optimised and up-regulated in 75% tumours compared to validated for tumour cell detection. The be important in normal bowel tissue. It has been included utility of methylation as a tumour marker predicting patients’ in the biomarker panel for the detection of has been demonstrated by several studies tumour response to CTC. To date blood and lavage samples have and we have established methods for been collected from sixty seven colorectal detecting DNA originating from tumour apoptosis-inducing cancer patients and from 21 controls and cells and for analysing several genes therapeutic agents analysis for CTC is proceeding. previously shown to be commonly methyl- ated in breast cancer cells. used to treat SET was also investigated as a therapeutic advanced colon target as its main function in colon cancer cancer.” is to inhibit the tumour suppressor protein Staff PP2A, thus promoting tumour growth. Chair of the combined Depart- Knocking out SET expression by RNA ments of Haematology and Medical interference showed that several tumour- Oncology promoting target proteins including TJ Price MBBS FRACP β-catenin were down-regulated, however these beneficial effects may be over-ridden Head of Clinical and Laboratory by the increased expression of the tumour- Haematology promoting oncogene ETS2. Further work is PG Bardy MBBS FRACP FRCPA needed to confirm this finding and to assess concomitant knockdown of ETS2. Another Head of Clinical Oncology biomarker found over-expressed in 65% KB Pittman MBBS MD FRACP of colon tumours is phospho-CK8 (PCK8). The presence of high levels of PCK8 is Head of Clinical Research thought to protect the cells from apoptosis TJ Price MBBS FRACP (cell death) and this may be important in predicting patients’ tumour response to Staff Specialists/Clinical Trials apoptosis-inducing therapeutic agents used RM Green MBBS FRACP FRCPA to treat advanced colon cancer. This work U Hahn MD FRCPA was a joint collaboration with Flinders and S McRae MBBS FRACP FRCPA Adelaide Proteomics facilities. JE Norman MBBS FRACP WK Patterson MBBS FRACP K Robinson MBBS FRCPA FRACP A Townsend MBBS FRACP
TQEHresearch Research Report 2009 30 Chief Medical Scientist and 3rd year Physiology (University of Laboratory Head Adelaide) lab placement (J Hardingham RJ D’Andrea PhD group) S Li Principal Medical Scientist and Group H Kakavand Leader J Gordon JE Hardingham BSc PhD D Lim J Ashby Clinical Associates T Price Collaborators A Townsend (1) Internal (TQEH): P Bardy A/Prof A Cummins, Department Gastro- P Hewett enterology and Hepatology, TQEH N Rieger Mr P Hewett, Colorectal Surgical Unit, Department of Surgery, The Royal Grant Funded Scientists Adelaide and Queen Elizabeth Hospitals, MP Raynor PhD Adelaide C Butcher MMedSc Mr N Rieger, Colorectal Surgical Unit, P Neufing PhD Department of Surgery, The Royal Adelaide and Queen Elizabeth Hospitals, Research Assistants Adelaide J Wrin BSc Mr D Walsh, Breast/Endocrine Unit, I Kanter BSc Department of Surgery, The Queen A Shivasami BSc MBiotech Elizabeth Hospital, Adelaide J Lake RN Clinical Trials Nurse (2) Other local and National: Clinical Trial Co-ordinator A/Prof S Barry, Department of Paediatrics, D King RN University of Adelaide, Adelaide Dr G Suthers, Familial Cancer Unit, Clinical Trial Manager Adelaide Women’s and Children’s S Yeend EN Hospital Dr T Chataway, Flinders Proteomic Clinical Trial Co-ordinators Facility, Flinders University P Cooper BSc Prof LB To, Department of Haematology, G Dymmott RN Institute of Medical and Veterinary J Jeffries BBiotech(Hons) BAppSc(Human Movement) Science, Adelaide A Griffiths (based at Lyell McEwin Hospital) Ms M Wallwork and Mr J Terlett, L Pirc BBiotech(Hons) MMedSci Adelaide Microscopy J Williams BScGen(Hons) Prof AF Lopez, Division of Human J Rowe PhD Immunology, Institute of Medical and D Cakouros PhD Veterinary Science, Adelaide A/Prof A Dobrovic, Molecular Pathology Clinical Trial Administration Research, Department of Pathology, Peter A Barr MacCallum Cancer Centre, Melbourne
Postgraduate Students PhD candidates G Arentz “Characterisation of protein biomarkers for diagnostic and therapeutic applications in colorectal cancer” C Kok “Identification and functional analysis of common gene expression changes between myeloid leukaemia datasets” N Rao “Mutations in RUN X1 in Polycythemia Vera”
TQEHresearch Research Report 2009 31 Dr I Lewis, Department of Haematology, NHMRC. (Project grant) Molecular genetics Institute of Medical and Veterinary of Polycythemia Vera. ($198,500 2009) Science, Adelaide 2008-2010, D’Andrea R, Scott H, Bardy P, Prof T Gonda, Diamantina Institute, for Melo J. Cancer, Immunology and Metabolic Medicine, University of Queensland, NHMRC. (2009 Equipment grant) The role Brisbane of renal dendritic cells in infection under Dr H Scott, Walter and Eliza Hall immunosuppression. ($11,848 2009) Institute, Victoria Coates PTH, D’Andrea R.
(3) International: The Cancer Council of South Australia. Dr C Mullighan, St. Jude Children’s (Project grant) A new prognostic multi- Research Hospital, Memphis, Tennessee, marker assay for early stage bowel cancer USA ($89,750 2009) Hardingham JE, Chataway T, Hewett P, Price T.
Grants The Cancer Council of South Australia. Amgen. Phase II study of second line (Project grant) Familial blood cancers therapy with Irinotecan, Panitumumab and ($101,500 2009) Scott H, D’Andrea RJ, Everolimus in metastatic colorectal cancer Suthers G, Bardy PG, Hughes T, Lewis ID, with KRAS wild type. ($100,000 2009) Mullighan CG, Hahn C. 2009-2010, Townsend A, Hardingham J, Price T. The Cancer Council of South Australia. (Project grant) KLF5 function in Acute Australian Research Council. (Linkage Project) Myeloid Leukaemia ($98,000 2009) Differentiation of cord blood stem cells into D’Andrea RJ, Brown A, Mullighan C, thymus (T) cells with regulatory phenotype Bardy P. and function. ($100,000 2009) 2009-2011, Barry SC, Zola H, D’Andrea RJ, Lewis I. The Queen Elizabeth Hospital. (Haematology-Oncology Scheme A grant) Cancer Australia. PETACC 6 trial, neoadjuvant EGFR pathway assessment in patients chemotherapy for T3/T4 rectal carcinoma. receiving anti angiogenesis therapy. ($20,000 ($159,266 2009) 2008-2010, Price TJ et al. 2009) Hardingham J, Townsend A, Price T.
Haemophilia Foundation Research Fund. The Queen Elizabeth Hospital. (Haematology- Thrombin Generation in Patients with Oncology Scheme A grant) Detection of Discrepant Haemophilia A. ($20,000 2009) occult disseminated tumour cells and tumour McRae S. DNA. ($60,000 2009) Raynor M.
Inner Wheel Australia. Optimisation of cord The Queen Elizabeth Hospital Research blood stem cell differentiation into T cells Foundation. (Small grant 2009) Identification with regulatory phenotype. ($62,500 2009) of mutations in molecules which package Barry SC, D’Andrea RJ, Lewis ID. DNA in leukemia and pre-leukemic disease. ($18,000 2009) D’Andrea R, Neufing P, Merck Sorono Pharma. EGFR pathway assess- Butcher C. ment in patients receiving anti angiogenesis therapy. ($30,000 2009) 2008-2009, Price The Queen Elizabeth Hospital Research TJ, Townsend A, Hardingham J. Foundation. (Small grant 2009) Determina- tion of biomarkers of resistance/sensitivity to NHMRC. (Project grant) Dissecting FLT3 Cetximab therapy in colorectal tumour cell signalling in acute myeloid leukaemia. lines using expression profiling PCR arrays. ($159,500 2009) 2007-2009, D’Andrea R, ($4,000 2009) Hardingham J, Price T. Gonda T. The Queen Elizabeth Hospital Research NHMRC. (Project grant) Functional validation Foundation. (Small grant 2009) Investigation of FoxP3 target genes in human regulatory T of OLFMG positive stem cells in colorectal cells. ($200,200 2009) 2009-2011, Barry SC, cancer. ($10,000 2009) Cummins AG, Grover Shannon F, Zola H, D’Andrea R. PK, Hardingham J, Price T.
TQEHresearch Research Report 2009 32 The Queen Elizabeth Hospital Research Foundation/Department of Haematology- Oncology. (Postgraduate Scholarship) ($18,724 2009) Rao N.
New grants awarded for 2010 Leukaemia and Lymphoma Society of USA. The role of OCT-1 Activity enhancers in improving the response of patients with low OCT-1 activity to imatinib (US$200,000 2010) 2010-2012, White D, Hughes T, D’Andrea RJ, Somogyi A, Melo J.
NHMRC. (Project grant) Klf5 function in normal and leukaemic haemopoiesis ($209,500 2010) 2010-2012, D’Andrea RJ, Mullighan C, Lewis ID, Jenkins N.
NHMRC. (Project grant) Dissecting the role of the IL-3 receptor alpha subunit and beta-catenin in Acute Myeloid Leukaemia ($187,500 2010) 2010-2012, D’Andrea RJ, Ramshaw H, Ekert P, Lewis ID, Barry SC.
Awards K Robinson. SA Health Award 2009: Dr Kathryn Robinson on behalf of the SA BloodSafe Program.
Acknowledgments The Department of Haematology - Oncology would like to thank AIB Labs, the Australian Red Cross Blood Service, The Cancer Council of South Australia, The Queen Elizabeth Hospital Research Foundation, The Familial Cancer Unit - Children, Youth & Women’s Health Service, the National Health and Medical Research Council, Flinders Univer- sity and the University of Adelaide for their generous support of this research.
TQEHresearch Research Report 2009 33 INTENSIVE CARE UNIT
Research Focus • Sepsis studies • Observational surveys • Patient safety • Nutrition studies • Outcome studies • Statistical method reviews Associate Professor Sandra Peake
“The ARISE study Sepsis Studies patients with severe sepsis. The study is Australasian Resuscitation In Sepsis NHMRC-funded and is being performed has been awarded Evaluation (ARISE) under the auspices of the ANZICS CTG. $2.4 million by ARISE is a phase III, multi-centre, ANZICS The purpose of this study is to assess the the NHMRC and CTG-endorsed, randomised, controlled effects of atorvastatin on the biological study evaluating early goal-directed and clinical outcomes of adult intensive is being conducted therapy in 1600 patients presenting to care patients with severe sepsis. The study over 2.5 years the Emergency Department with severe will establish whether a definitive phase sepsis in 35 Australian, New Zealand and III trial in Australia and New Zealand is through the Hong Kong hospitals. The study has been feasible and justifiable, and will provide Australian and awarded $2.4 million by the NHMRC and essential information on the cost and likely New Zealand is being conducted over 2.5 years through sample size for such a trial. Recruitment the Australian and New Zealand Intensive commenced November 2007 and is due for Intensive Care Care Centre Research Centre, Department completion in June 2010. Centre Research of Epidemiology and Preventive Medicine, Monash University. Associate Professor A controlled comparison of eritoran Centre, Sandra Peake is the Chair of the ARISE tetrasodium and placebo in patients Department of Management Committee and Patricia with severe sepsis Williams is the Research Coordinator A multi-centre, international, industry- Epidemiology representative on the ARISE Management sponsored randomised, double-blind, and Preventive Committee. The study commenced at placebo-controlled study. The purpose of Medicine, Monash TQEH in October 2008 and is collabora- this research study is to assess the safety tion between the Emergency Department and efficacy of an experimental drug called University.“ and the Intensive Care Unit. The Queen eritoran tetrasodium (eritoran) in patients Elizabeth hospital is currently the highest with severe sepsis. Eritoran belongs to a recruiting site. group of drugs called Lipid A antagonists. Previous studies have indicated that eritoran An economic evaluation of resuscita- works by blocking the effect of toxic tion in sepsis products and by reducing the production of An economic evaluation of the multi- inflammatory chemicals that can contribute centre, ARISE randomised controlled trial during an infection to the symptoms of of early goal-directed therapy in patients sepsis. The study will also measure how presenting to the Emergency Department health care costs are affected by its use. with severe sepsis will be conducted in The study commenced in May 2007 and a cohort of patients randomised to the continued in 2009. ARISE RCT. Cost per quality life year gained will be evaluated. The study was awarded Sepsis and DIC a $100,000 grant from the Intensive A multi-centre, industry-sponsored Care Foundation in November 2008 and randomised, double–blind, placebo– commenced in 2009. controlled, Phase-2B study is underway to assess the safety and efficacy of a drug STATInS: Study of atorvastatin therapy called ART-123 on subjects with sepsis and in sepsis disseminated intravascular coagulation. A phase II randomised controlled trial ART-123 is thought to act by stopping of atorvastatin therapy in intensive care thrombin-mediated clotting and enhancing
TQEHresearch Research Report 2009 34 Protein C activation at the site of clotting TAME: An Audit of the Time and “The study aims rather than systemically; thereby reducing Financial Costs involved in the Review the risk of bleeding. Recruitment at TQEH Process of Multi Centre Clinical Trials in to identify completed in 2009. Australia and New Zealand associated risk The TAME (Time And Money Evalua- Efficacy and Safety of Drotrecogin tion) project is an observational study of factors, compare Alfa (Activated) in Adult Patients with important aspects of the scientific and cardiac and Septic Shock ethical review of multi-centre medical A randomized, double-blind, placebo- research in intensive care across Australia non-cardiac controlled, multicenter, Phase 3 study of and New Zealand. This study aims to complications, drotrecogin alfa (activated) administered compare between existing systems of local as a continuous 96-hour infusion to adult committees versus centralized authorities mortality, length patients with septic shock commenced the overall duration of the scientific and of ICU and hospital in 2008. The purpose of this placebo- ethics approval process for one or more controlled study is to determine if drotrec- clinical trials seeking contemporaneous stay in patients ogin alfa (activated) treatment provides approval in Australia and New Zealand. with prolonged significant mortality reduction and organ Also to be compared between local and function improvement in patients with centralised approval systems are the fees QTc interval and septic shock compared with placebo charged for the approval process, and QTc dispersion.“ treatment in patients receiving the current an estimate of the direct time required standard of care for septic shock. This study preparing and supporting the review process will also assess the effectiveness of drotrec- by local research staff at each participating ogin alfa (activated) in reducing 28-day site. It is planned that the TAME study will mortality in patients with septic shock and examine two projects seeking approval, concomitant severe protein C deficiency at these being firstly an investigator-initiated baseline. Recruitment commenced August study and secondly a commercially- 2008 and continued in 2009. sponsored study. This study is endorsed by the ANZICS CTG and received funding from the Intensive Care Foundation. Mrs Patricia Observational Studies Williams (TQEH ICU Research Coordinator) STATInS TIME (Time-In-Motion is a member of the study Management Evaluation) Study Committee. A time and motion evaluation study of a phase II randomised controlled trial Prolonged QT interval in the of atorvastatin therapy in intensive care ICU-incidence, risk factors and patients with severe sepsis (STudy of outcome, a prospective multi-centre Atorvastatin Therapy In Sepsis). This observational study sub-study is a prospective, observational, This study is being undertaken to determine time-in-motion evaluation study using the incidence of prolonged QTc interval a real-time daily management log to and QTc dispersion in critically ill patients document the time required by Research admitted to the ICU. The study aims to coordinators to perform all aspects of the identify associated risk factors, compare STATInS study. The findings from this study cardiac and non-cardiac complications, will assist with the understanding of the mortality, length of ICU and hospital stay time required to perform the coordination in patients with prolonged QTc interval of a research project. This knowledge may and QTc dispersion. This study was done be used at a local level for sites to project in collaboration with the Royal Adelaide and justify operating costs of local personnel Hospital Intensive Care Department. and to assess the economic feasibility of a Preparation is underway to submit the study. This information will also be used to results of this study for publication. inform the planning and design of future studies and to provide more accurate staff The epidemiology of radiocontrast cost estimates for future grant applications. exposure in critically ill Australian adults: a prospective, multi-centre, observational study A study to determine the incidence of intravascular radiocontrast (contrast) nephropathy following exposure to contrast
TQEHresearch Research Report 2009 35 “The survey aims among adults admitted to Intensive Care paracetamol) in intensive care patients Unit’s (ICU) in Australia is completed. This continues. The study is funded by a $15,000 to gain a better study is in collaboration with the Royal grant from the Intensive Care Foundation. understanding Prince Alfred Hospital Intensive Care Unit. of both strengths Preparation is underway to submit the Understanding the safety culture results of this study for publication. in Australian Intensive Care Units: related to establishing a baseline for quality patient safety Point Prevalence Program improvement and areas for The Point Prevalence Program, performed A survey of the safety culture in Australian under the auspices of the ANZICS CTG, Intensive Care Units (ICUs) was conducted in improvement aims to provide the structure for individual 2009 by a sub-group of the Quality Advisory as well as researchers to conduct basic observational Panel of the Australian College of Critical Implementation Point Prevalence Studies to inform future Care Nurses (ACCCN). This was funded by research, while minimising the workload ACCCN, the Australian and New Zealand of targeted on participating ICUs by combining studies Intensive Care Society (ANZICS) and the improvement using a common and standardised Case Research Centre for Clinical and Community activities in focal Report Form, on predictable dates. The two Practice Innovation. The survey aims to gain studies conducted in 2009 where an evalua- a better understanding of both strengths areas that have tion of the implementation of “Process of related to patient safety and areas for the potential to Care” practices in your ICU and an evalua- improvement as well as Implementation of improve patient tion of temperature management practice targeted improvement activities in focal areas for patients with acute brain syndromes. that have the potential to improve patient care.” This program is funded by the Intensive Care care. Bernadette Grealy, Clinical Service Foundation. Coordinator, Intensive Care Unit is a co-investigator for this study.
Nutrition Studies Early total parenteral nutrition Outcome Studies A multi-centre, level 1 randomised, Radiocontrast-induced nephropathy in controlled trial comparing early total ICU patients parenteral nutrition to standard nutritional A retrospective study examining the support in the critically ill patient was incidence of, and risk factors for, radiocon- commenced in December 2006. The study trast-induced nephropathy in ICU patients is NHMRC-funded and is being performed has been completed. Preparation is under the auspices of the ANZICS CTG. underway to submit the results of this study Associate Professor Peake is an associate for publication. investigator and member of the study Management Committee. Outcome from Idiopathic Pulmonary Fibrosis A retrospective study examining the outcome Patient Safety of patients with idiopathic pulmonary fibrosis Assessing the safety of a continuous admitted to ICU for respiratory failure has potassium chloride infusion in critical been completed. Published in Critical Care & care: A randomised controlled trial Resuscitation 2009. This prospective non-blinded, randomised, controlled trial aims to ascertain whether Gentamicin and creatinine clearance administration of potassium chloride is In conjunction with Dr Terry Jones, Pharmacy safer by intermittent or continuous infusion. Department, a prospective observational Recruitment completed in September 2009 study comparing various modes of creati- and data analysis is underway. Funding was nine clearance in ICU patients, including received from The Queen Elizabeth Hospital the clearance of gentamicin is completed. Research Foundation to assist with this study. Published in Anaesthesia and Intensive Care, December 2009. Comparison of haemodynamic effects of paracetamol in the critically ill Gentamicin-computer derived dosing A randomised, controlled trial assessing and clearance in ICU the safety and haemodynamic effects of In conjunction with Dr Terry Jones intravenous paracetamol (versus enteral (Pharmacy) this study is examining the
TQEHresearch Research Report 2009 36 benefits of using a computer derived dosing the 2009 pandemic influenza A (H1N1) virus “The study aims schedule and creatinine clearance estimates through health care systems in developed for all patients prescribed gentamicin in the countries during winter in the Northern to enrol 10,000 Intensive Care Unit. This study is continuing. Hemisphere. A/Professor Sandra Peake patients over a is a member of the study Management 2-3 month The application of advanced Committee. The results of the study thus far statistical techniques in the analysis of were published in the New England Journal period utilising outcome data of Medicine in October 2009. The study will information specific A number of studies are ongoing defining continue into 2010. the role of advanced statistical analysis in to patients and to outcomes research and meta-analysis. Studies on the critically ill represent institutions to co-operative undertakings between all the The correlation between waist Nursing and Medical staff in the Intensive assess the relative circumference and outcomes in Care Unit. Many thanks to our Research impact of factors critically Ill patients Coordinator, Mrs Patricia Williams. on patient survival The study is a prospective, single centre, epidemiological study to be conducted to hospital over a 12 month period involving patients Staff discharge.” who are admitted to the intensive care unit Director for more than 24 hours. The study aims MS O’Fathartaigh MB Bch BAO FFARCS (Ire.) to determine whether there is a correla- FFICANZCA tion between waist circumference and morbidity, ICU mortality, 28 day mortality, Consultant Specialists hospital mortality and 6 monthly mortality JL Moran MB BS FANZCA FRACP FJFICM MD in critically ill patients. Recruitment is due SL Peake BM BS BSc(Hons) FJFICM PhD for completion July 2010. S Moodie MB CHB FJFICM K Lee MBBS MBus FACEM FJICM Discharge and Readmission Evaluation S Jacobs MBChB FRCA FANZCA study (DARE) A multi-centre prospective observational Research Coordinator study (audit) of consecutive patients P Williams RN IntCCert BN discharged from the ICUs of hospitals in Australia and New Zealand and is being Senior Registrars / Registrars / Resident performed under the auspices of the Medical Officers ANZICS CTG. The study aims to enrol R Chalwin MB CHB 10,000 patients over a 2-3 month period A Benedict MBBS utilising information specific to patients and TM Vinodh MBBS DA DNB FISCCM to institutions to assess the relative impact H Tewari MBBS MD of factors on patient survival to hospital K Arpudaswamy MBBS MD discharge. The DARE Study aims to identify V Biradar MBBS DMB the patient and system factors that increase C Nottage MBBS preventable morbidity and mortality in J Ng MBBS patients who are discharged alive from ICU. J Raj MBBS MS Recruitment was completed in December 2009. Nursing staff B Grealy RN RM IntCCert BN MN(Res) S Flynn RN IntCCert Infinite L Esca RN IntCCert An inception-cohort study was conducted R Fraser RN IntCCert in all Australian and New Zealand intensive J Phillips-Hughes RN IntCCert G Dip Nursing care units (ICUs) during the winter of 2009. L Sheffield RN IntCCert This project involved the establishment of E Williams RN IntCCert a real-time registry and the collection of clinical health information in patients with Studies have also been undertaken in influenza A infection (including patients collaboration with Dr Terry Jones, Pharmacy, with novel H1N1 2009) admitted to the TQEH and Dr Tobias Otto, TQEH Emergency Intensive Care Unit. This study will assist Department and the Royal Adelaide Hospital planning for the treatment of infection with and Royal Prince Alfred Intensive Care Units.
TQEHresearch Research Report 2009 37 Grants Queen Elizabeth Hospital Research Founda- tion. (Small grant 2009) An investigation of pharmacokinetic-pharmacodynamic charac- teristics of various beta-lactam antibiotics in patients with sepsis using microdialysis ($4,000 2009) Peake S, Robertson T, Lipman J, Roberts J, Roberts M.
The Queen Elizabeth Hospital Research Foundation. Assessing the safety of continuous potassium chloride infusion in critical care: a randomised controlled trial. ($13,636 2009) Peake S.
TQEHresearch Research Report 2009 38 MEDICINE, University of Adelaide Discipline of
Research Focus
From genes and cells to population health • Basic research studies of the physiology of zinc in the respiratory system • Population research on chronic disease • Patient safety and quality improvement • Nutritional problems affecting older people • Health Services and systems research • Undergraduate and postgraduate assessment Professor Richard Ruffin
Overview Professor Richard Ruffin is involved in “Research of The Department of Medicine has major studies on asthma and COPD epidemiology, educational involvement in Undergraduate and Postgrad- and continuing a population health study uate teaching and training; undergraduate examining chronic diseases (diabetes, obesity, assessment at the and postgraduate curriculum development asthma, COPD, cardiac risk factors, renal undergraduate and and undergraduate postgraduate assess- disease) within the North Western Adelaide ment, basic and applied research; clinical population. This work is defining incidence, postgraduate level service and management. Members of the severity, undiagnosed disease prevalence, and has commenced, department are involved in basic science the burden of disease in the population. A and will provide an research, clinical research, and epidemio- linked data set is facilitating this work. The logical research across the disciplines of cohort is providing material to look at genetic evidence base for Neurology, (see Neurology Report), Ageing, links to disease and risk factors. Research of future junior doctor Cardiology (see Cardiology report), chronic educational assessment at the undergraduate diseases and risk factors; and population and postgraduate level has commenced, and training.“ health. Workplace based assessment is will provide an evidence base for future junior being developed progressively with training doctor training. Workplace based assessment modules and calibration exercises. training modules for national application and national calibration are being developed. A/Prof Renuka Visvanathan is the Director of the Aged and Extended Care Services at The A/Prof Bob Adams is the Director of The Queen Elizabeth Hospital (TQEH) and has Health Observatory in The Institute (BHI). established a research program in ageing, Along with co-investigators at TQEH and in particular nutritional frailty. In 2009, she collaborators elsewhere, The Observatory was awarded the Australia and New Zealand is continuing work on a number of issues Society for Geriatric Medicine Lundbeck related to healthy ageing and chronic Fellowship. As part of this fellowship, she disease, using population health data as attended a one week seminar on depression a basis for developing community-based and dementia in Denmark. She also visited intervention trials. He is continuing work three geriatric medicine centres in the United on the second phase of the ARC-funded Kingdom. 2009 has also been a successful Nutrition, Obesity, Lifestyle and Environ- year in terms of research grants success ment Study (NOBLE) examining the effect of with two NHMRC grants being awarded to obesity on “baby boomers” and workforce commence in 2010. She was also part of the participation. A/Prof Adams has a major MNA International Initiative which developed interest in health literacy and is the Chair an improved nutritional screening tool- the of the South Australian Health Literacy Mini Nutritional Assessment Short Form. A/ Alliance. He is collaborating with colleagues Prof Visvanathan is also a chief investigator in Switzerland and across Europe in several with the Health Observatory based at the projects looking at the relationship of health Queen Elizabeth Hospital. This team was literacy and health outcomes. A/Prof Adams successful in securing a $1.25 million five year is a chief investigator on a major NHMRC- program grant from The Queen Elizabeth funded project that will look at the relation- Research Foundation in 2009. ship between cardiac disease in men and
TQEHresearch Research Report 2009 39 “The North West the effects of sex steroids, obesity and other Disease Research Program supported by The novel factors such as endocrine disruptors. He Queen Elizabeth Hospital Research Foundation. Adelaide Health is also a chief investigator on two NHMRC- This Program grant aims to better understand Cohort Study funded projects led by Prof Mark Daniels at the molecular and cellular mechanisms of (NWAHS), a University of South Australia that will examine inflammation underlying chronic inflammatory the relationship between space and place and diseases; to develop pre-clinical models for population study of the metabolic syndrome. investigation of inflammatory pathways and to chronic disease now identify novel therapeutics for treating chronic Dr Peter Zalewski continued his studies on inflammation. Drs Lang and Zalewski are also in its tenth year of the role of zinc in regulation of apoptosis in working with A/Prof Toby Coates, Transplanta- follow up, the respiratory system and in asthma, funded tion Unit and Dr Chiara Murgia, INRAN, Italy, by an NHMRC project grant with Professor to investigate proteins that transport zinc in has contributed Richard Ruffin and Dr Chiara Murgia (a visiting pancreatic islets and airway cells. substantially to research fellow from the Institute for Food and chronic disease Nutrition in Rome. Contributing to this work Professor David Wilson is an epidemiologist are Research Officer Rhys Hamon, looking employed by the Department of Medicine research.” at the effects of intracellular Zn on expres- to contribute a major population focus to sion of a major inhibitor of apoptosis XIAP, health and health outcomes. This includes the and second year PhD student Eugene Roscioli management of population studies and applied whose thesis concerns the role of XIAP in research staff. He was the founder of several airway biology and asthma. The grant focuses population surveillance systems including on the role of Zn ions in regulation of the the South Australian Health Omnibus Survey family of Zn-rich Inhibitor of Apoptosis Proteins (SAHOS), an annual population household (IAPs). A number of new techniques have survey, which provides population health data been established in the laboratory, including for major government and non-government Western blotting and mammalian cell gene health organisations and underpins a number expression techniques to enable the experi- of population health research studies. He ments to be performed. Dr Zalewski is Chief is a co-founder of the Health Observatory Investigator A (CIA) on a new NHMRC project and the North West Adelaide Health Cohort grant to commence in 2010. This is a collabo- Study (NWAHS). The Health Observatory is rative project looking at the role of zinc in a specialist research unit established to study phagocytosis with A/Prof Sandy Hodge and the biomedical and anthropological aspects of A/Prof Hubertus Jersmann (Hanson Institute health and disease at the population level and and Discipline of Medicine, RAH). PhD student the ways these can be modified to promote Lata Jayaram has recently submitted her thesis healthy ageing. The North West Adelaide and a paper on the zinc-related aspects of this Health Cohort Study (NWAHS), a population study. Dr Zalewski is a co-supervisor of another study of chronic disease now in its tenth year PhD student Razinah Sharif who is working of follow up, has contributed substantially to on aspects relating to measurement of zinc chronic disease research. Professor Wilson is levels and deficiency in human buccal cells, in a recognised international expert on popula- collaboration with scientists at CSIRO, WCH tion surveillance and a member of the World and the Waite Research Institute. Dr Zalewski Association on Risk factor Surveillance (WARFS). is also a member of CIDR (Centre for Inflam- He has contributed substantially to the thinking matory Diseases Research), a cross-discipline on population research and its application collaboration between scientists and clinicians to new areas such as infectious diseases and at TQEH and The Basil Hetzel Institute, focusing health literacy. He is a strong advocate of the on chronic inflammation and especially the role need for multi-disciplinary research of health of the inflammasome. Dr Zalewski chaired a problems for the development of sustainable symposium on zinc and apoptosis/inflamma- health solutions and improved population tion at the International Society for Zinc Biology health outcomes. in Jerusalem in Nov 2009. Prof John Horowitz, A/Prof Beltrame and A/Prof Dr Carol Lang, NHMRC Peter Doherty Research Zeitz have their research interests detailed in Fellow, conducts research into the role of zinc the Cardiology section of this report. and airway inflammation in chronic respiratory diseases such as asthma and chronic obstruc- A/Prof Simon Koblar has his research interests tive pulmonary disease. Dr Lang is also a Chief detailed in the Neurology section of this Investigator for the Centre of Inflammatory report.
TQEHresearch Research Report 2009 40 Staff Professor of Medicine RE Ruffin BSc (Hons) MBBS (Hons) MD FRACP
Professor in Cardiology J Horowitz MBBS BMedSc(Hons) PhD FRACP
Associate Professors RJ Adams MBBS MD FRACP J Beltrame PhD FRACP S Koblar MBBS PhD FRACP R Visvanathan MBBS PhD FRACP CJ Zeitz MBBS FRACP S Rajendran MBBS FRACP PhD
Research Fellows PD Zalewski BSc(Hons) PhD
Project Officer DH Wilson BEd MPH PhD
Hospital Scientist AG Milton BSc(Hons)
Technical Officer SL Appleton BSc(Hons) R Hamon BSc(Hons)
Personal Assistant E Mourtzios A Brown (from December 2009)
Postgraduate Students
L Jayaram MBChB FRACP “Asthma severity and perception study”
SL Appleton BSc(Hons) “Complexities of the relationship between asthma and obesity”
S Yu MBBS FRACP “CASA cytokines, adioposity, sarcopenia and ageing: a pilot study”
E Roscioli BSc(Hons) “The role of ZIP 1 in regulating apoptosis in cells in the respiratory epithelium”
TQEHresearch Research Report 2009 41 Peter Doherty Research Fellow CJ Lang BSc(Hons) PhD
Postdoctoral Fellow C Murgia PhD (Visiting)
Awards R Visvanathan. Lundbeck Fellowship awarded by Australia and New Zealand Society for Geriatric Medicine (travel and accommoda- tion costs).
Grants rhinosinusitis ($180,000 2009) 2009-2011, ARC. (Project grant #LP 0990065) Australian Wormald PJ, Koblar S, Rischmueller M, baby boomer generation, obesity and work - Lester S, Lang C, Tan LW, Zalewski P. patterns, causes and implications. ($489,764 2009) 2009-2011, Hugo G, Wittert G, Adams RJ, Cobiach L, Daniel N, Findley CC, Taylor New NHMRC grants awarded for 2010 AW, Wilson DH, Winefield HR, Woolacott AL, NHMRC. (Project grant # 627178) The Ruffin RE. effects of testosterone and a nutritional supplement on hospital admissions in NHMRC. (Project grant #519206) Airway under-nourished, older people. [TQEH Led epithelial IAPs and their interaction with Zn multicentre RCT] ($1,018,438 2010-2012) ions. ($88,500 2009) 2008-2010, Zalewski Chapman I, Visvanathan R, Naganathan V, PD, Ruffin RE, Murgia C. Hunter P, Karnon J, Horowitz M, Lange K, Cameron I. NHMRC. (Australian Biomedical (Peter Doherty) Research Fellowship) The role of NHMRC. (Project grant #627189) Gastric, zinc in the respiratory system and in chronic small intestinal and cardiovascular obstructive pulmonary disease. ($67,500 mechanisms of postprandial hypotension. 2009) 2006-2010, Lang CJ. ($676,500 2010 -2012) Jones KL, Gentil- core D, Visvanathan R, Chapman I, Rayner TQEH Research Foundation Strategic Initia- C, Horowitz M. tives Funding. (Program grant) The Health Observatory. ($250,000 2009) 2009-2013, NHMRC. (Project grant #627227) Effect of Adams RJ, Wilson D, Hill C, Visvanathan R, sex steroids, inflammation, environmental Wittert G, Ruffin R. and biopsychosocial factors on cardiometa- bolic disease risk in men. ($1,763,013 TQEH Research Foundation. (Small grant) Is 2010-2012) Wittert G, Wilson D, Travison the X-linked inhibitor of apoptosis a suscep- T, Adams R, Taylor A, McKinley J, Jenkins A, tibility gene for asthma? ($5,000 2009) Milne, R, Hugo G, Atlantis E. Zalewski P, Roscioli E, Lester S. NHMRC. (Project grant # 627223) TQEH Research Foundation/Discipline Zalewski P, Hodge S, Jersmann H. Alveolar of Medicine. (Postgraduate Scholarship) macrophage zinc and zinc transporters ($17,022 2009) Roscioli E. and their role in phagocytosis. ($278,750 2010-2012). TQEH Research Foundation Strategic Initia- tives Funding. (Program grant) Inflammatory mechanisms and therapies in chronic disease- asthma, COPD, stroke, cerebrovascular disease, rheumatology diseases and chronic
TQEHresearch Research Report 2009 42 TQEHresearch Research Report 2009 43 Neurology Unit
Research Focus • Investigating environmental and genetic risks for stroke • Investigation of the therapeutic application of adult stem cells to repair the brain following stroke • Investigation of inflammatory pathways in stroke and other diseases • Primary Health Stroke Prevention Research • Statistical parametric mapping analysis of regional cerebral blood flow (Nuclear Medicine collaboration) • Epilepsy Research (clinical trials of new anti-epileptic medication) Dr MK Robinson • Dementia Research (clinical trials of new Alzheimer’s Disease medications) • Multiple Sclerosis (clinical trials of new RRMS treatments)
TQEHresearch Research Report 2009 44 Overview SRP is participating in the Australian Stroke Genetics Collaboration (ASGC), a new multi- The Neurology Department has two main state, multi-centre Australian study into the research arms: genetic causes of stroke. The ASGC Study Stroke related research which involves will run over several years to gain a better both genetic investigations into risk for understanding of the genes involved in stroke stroke, stem cell therapy to repair the brain and sample numbers will be increased by following stroke, inflammatory pathways further patient collections, thereby increasing involved in stroke, and also Primary Health the power of the study. Since commencing Stroke Prevention Research his PhD in April 2009, Mr Michael Djukic has Clinical trials sponsored to investigate the designed a proteomic method for biomarker benefit to our patient populations of new discovery in patients diagnosed with transient therapeutics in dementia, epilepsy and ischaemic attack. Clinical criteria have been multiple sclerosis. developed for candidate patient selection, and blood samples from patients presenting to the Stroke Research Programme (SRP) Community-Based rapid Access TIA (COMBAT) The SRP, directed by A/Prof Simon Koblar clinic have been collected prospectively. and co-director Dr Anne Hamilton-Bruce, forms a research collaborative between the Ms Wai Khay Leong, an international PhD School of Medicine & School of Molecular scholar from Malaysia who obtained a Biomedical Science, University of Adelaide University of Adelaide International PhD and Department of Neurology, The Basil Scholarship, being ranked seventeenth in Hetzel Institute for Medical Research, The the University for 2009, has joined the SRP Queen Elizabeth Hospital (TQEH). At the as a PhD candidate. Her major PhD project beginning of 2009, the TQEH component of is to investigate the functional use and SRP moved to the first floor of the new Basil underlying mechanisms of using Dental Pulp Hetzel Research Institute facility, TQEH. Stem Cells (DPSC) in a rat stroke model. This year she has worked on the completion of The ongoing study of endothelial function a pilot study and is currently writing up the in cerebral small vessel disease (CSVD) with results from this study. PhD student Ms Ada Lam has, with recruit- ment and data analysis now complete, At the Basil Hetzel Institute (BHI), SRP team progressed well and been finalised. A total members also collaborate within the Centre of one hundred and thirty two participants for Inflammatory Diseases Research (CIDR). were assessed during the study period. Four teams (ENT, Neurology, Respiratory and Collaborators include Dr E Win Khoo and Rheumatology) in the BHI joined to form Dr Sandy Patel (MRI and CSVD), and Ms CIDR in 2008 and are supported via a three Skye McLennan and A/Prof Jane Mathias year TQEH Research Foundation Program (Cognition and CSVD) from the School of grant. CIDR collaborators have expertise Psychology at the University of Adelaide. in many of the main chronic diseases, Further laboratory collaboration includes e.g., asthma and emphysema, sinusitis, that with Ms Rosanna Tavella, Ms Natalie arthritis and stroke. Common inflamma- Cutri and A/Prof John Beltrame (SNPs and tory pathways will be investigated and then cardiology). The SRP also collaborated targeted by new types of therapies such as with Dr Celia Chen from the Department cell therapies, zinc and fish oil. of Ophthalmology, Flinders Medical Centre in a study to determine if measurement of Dr Elaine Leung’s PhD project aims to define retinal nerve fibre layer (RNFL) thickness the characteristics of Trans Ischaemic Attack with optical coherence topography is an (TIA) assessment and management that effective non-invasive marker of brain currently exist in a prospective study and volume changes in patients with clinical to determine if a community-based rapid or sub-clinical leukoaraiosis. This paper is access TIA clinic improves patient stroke currently under review for publication. With outcome and assess its cost-effectiveness. respect to the IP from our earlier research, The project also aims to characterise the on which Ms Lam’s work builds, Athero- role and impact of General Practitioners gen’s ‘Mutations Associated with Stroke’ with a Special Interest (GPwSI) in TIA care patents have been issued in the United and stroke prevention, as well as test an States of America and Australia. educational module on TIA assessment and
TQEHresearch Research Report 2009 45 “A $20,000 management for general practice in improving The Search Study confidence and knowledge in TIA care. The SEARCH study is an NHMRC funded donation, pledged population study of stroke with a budget last year by a Mr Victor Krawczyk’s Honours research of $700,000 over three years. The study grateful former project aimed to understand whether a is based at TQEH and is a prospective workgroup of medical scientific researchers population based study of stroke incidence stroke patient, was a community of practice and to learn according to established ‘ideal’ criteria. has been used this about members’ understandings of language, Population stroke incidence studies are medicine and the body in their work practices. the only reliable means of identifying the year to support This exploratory study took a workgroup of incidence of stroke which varies widely in SRP research. professionals as the case to research for its different regions. There has never been a SRP team ‘intrinsic’ worth using a case study qualita- population based stroke study in South tive approach. Analysis showed that the Australia. The SEARCH study has an urban members also workgroup had elements of a community of arm, covering 140,000 residents around participated in practice and that particular understandings of North West Adelaide, and rural arms in a language, medicine and the body informed variety of locations in South Australia. The National Stroke their work practices. The findings are project is a collaboration between TQEH, Week activities transferable as the case has sufficient context the School of Population Health, and the dependent similarities with other research School of Rural Health at The University of to raise public workgroups. These outcomes may enhance Adelaide. Reliable data on incidence, type awareness of stroke the implementation of translational research and care requirements for stroke is vital in symptoms...” through shared understandings of medicine planning for adequate stroke health care in and the body. This can assist in opening a the immediate future. new field of investigation in organisational studies by extending community of practice theory to under-researched professional Thrombolysis Audit configurations in the biomedical sciences. A state based population thrombolysis audit is being performed as a separate project Dr Anne Hamilton-Bruce continues a collab- within the stroke unit. 164 cases of stroke oration with Ms Rosie King, Dr John R Moss where thrombolysis has been administered and Dr Afzal Mahmood, Department of have been identified. Timing, complications Public Health at the University of Adelaide, and outcome will be reported to evaluate investigating the impact that a hospital the safety and efficacy of thrombolysis in admission can have on the continuing ability South Australia. This audit will be used of Home and Community Care (HACC) as a bench mark and repeated after the clients (older people and people with implementation of the SA Stroke Plan. disability) to remain living in their home.
Team members have continued to present Clinical Trials at community meetings to raise awareness Epilepsy about our research as well as funding needs, Seven trials of new anti-epileptic drugs to support research. Once again, the SRP were undertaken throughout this year, one was a recipient of donations throughout of which is still actively recruiting. These the year. A $20,000 donation, pledged last trials will allow access to new anti-epileptic year by a grateful former stroke patient, has drugs that may not become available to the been used this year to support SRP research. general public until Pharmaceutical Benefits SRP team members also participated in Scheme (PBS) listing and allows develop- National Stroke Week activities to raise ment of valuable clinical experience in the public awareness of stroke symptoms, and utilisation of these drugs. promoted a public lecture given by A/Prof Koblar in the lecture theatre of the new Basil Dementia Hetzel Research Institute building. We also The Memory Clinic and Clinical Cognitive received $100,000 from the Catholic Church Research Units participate in many Interna- and $10,000 from Stroke SA for Stem Cell tional studies. Dr Karyn Boundy is the Therapy research in 2009. In December we Chairperson of the Australasian Consor- were awarded $75,000 by the Centre for tium of Centres for Clinical Cognitive Stem Cell Research, Robinson Institute for Research (AC4R) to continue facilitation further stem cell therapy studies in 2010. of clinical trials in memory conditions in
TQEHresearch Research Report 2009 46 Australasia. She has also been selected as Roche are sponsoring a 30 week add on “The cognitive the South Australian and AC4R representa- study of RO5313534, to Aricept 5mg or tive for Neurosciences Trials Australia – a 10mg for mild to moderate Alzheimer’s profile of S 38093 clinical trials platform with “nodes” in each Disease. RO5313534 is an agonist of the suggests this neurological subspecialty area to facili- alpha 7 nicotinic acetylcholine receptor; compound could tate both investigator driven and to also evidence indicates that activation of to attract pharmaceutical company early Nicotinic alpha-7 receptor is critical for treat episodic, stage phase I – III research to Australia. Dr learning and memory. spatial and Boundy has spoken at local General Practi- tioner (GP) division, national and interna- CL2-38093-005 (S 38093) is a Servier Phase working memory tional meetings about aspects of dementia IIa study for mild to moderate Alzheimer’s deficits found management and diagnosis of less common disease. S 38093 is an H3 histaminergic dementias e.g., frontal lobe and tauopa- receptor antagonist, and is predicted to in Alzheimer’s thies. She has participated in an analysis of have cognitive enhancing and arousal disease.” antipsychotics on behavioural and psycho- properties in humans. The cognitive profile logical symptoms associated with dementia, of S 38093 suggests this compound could which subsequently aided the PBS treat episodic, spatial and working memory reimbursement of Risperidone for BPSD. A deficits found in Alzheimer’s disease. satellite Neurology/Memory Clinic has been set up in Port Lincoln via Rural Health SA. Disease Modifying Trials in Alzheimer’s Disease The study with the Rheumatology Unit on 3133K1-3000/1-WW are twin protocols neuropsychological, cognitive, behavioural using a humanised anti amyloid-beta peptide and imaging with MRI and SPECT in monoclonal antibody (AAB001). These are Sjogren’s Syndrome is submitted for review eighteen month studies with multiple doses for publication. of intravenously administer bapineuzumab in subjects with Mild to moderate The Prospective Research in Memory Clinics Alzheimer’s Disease, who are Apolipoprotein (PRIME) database continues to study all E έ4 CARRIERS or NON CARRIERS compared types of dementia patients are being with placebo subjects. Subjects will be assessed every twelve months over a three stratified according to Mini-Mental State year period. This database allows compar- Examination score 16-21/30 - 21-26/30 ison with centres interstate and interna- and concomitant cholinesterase inhibitor tional and to provide epidemiological data and/or Memantine use. on our patient group. An eighteen month Phase 2 Pfizer study Alzheimer Symptomatic Trials of Multiple Doses of PF 04360365 in Eight trials have been commenced, Patients with Mild to Moderate Alzheimer’s completed or are in extension phase. Disease is progressing. PF-04360365 is a E2020-G00-328 (Aricept 23mg SR) humanized monoclonal antibody directed and AVA102675 (Rosiglitazone) were against an epitope encompassing the C completed. Further trials of Aricept 23mg terminal amino acids of the (Amyloid Beta) SR are anticipated, while lack of efficacy for Aβ1-40 peptide derived from the Amyloid Rosiglitazone in Alzheimer’s disease saw this Precursor Protein (APP). The compound study ceased. is postulated to decrease Aβ in the brain, whether present as soluble monomers or A 24-48 week GSK study is continuing to oligomers or in plaques. investigate SB-742457 added to existing donepezil (Aricept) treatment in volunteers The Medivation/Pfizer sponsored DIM18 with mild to moderate Alzheimer’s disease. (Dimebon) Phase III study for mild to SB-742457 is an oral selective 5HT6 moderate Alzheimer’s Disease is vigorously receptor antagonist. recruiting. Dimebon is postulated to have disease modifying mitochondrial stabilisa- Lundbeck are sponsoring a 30 week, multi- tion properties and binds with high potency center, evaluation of Lu AE58054, a selective to select serotonin receptors (5-HT6 and serotonin receptor 6 (5-HT6 receptor) 5-HT7), alpha-1 adrenergic receptors antagonist. in patients with moderate (subtypes 1A, 1B, and 1D) and alpha-2 Alzheimer’s disease. adrenergic receptors (subtype 2B). Dimebon
TQEHresearch Research Report 2009 47 additionally binds to histamine H1 and H2 T-cell proliferation for the next 2 years. “Firategrast has a receptors and is a dual cholinesterase and The Phase II study has shown significant similar selectivity NMDA-receptor antagonist. reduction of disease activity on MRI scans and pharmaco- and a trend towards lower annualised Multiple Sclerosis relapse rates and disability. The current dynamic activity Many new exciting disease modifying Phase III study will compare 2 different to natalizumab, products are being tested. Clinical trials in doses of Teriflunomide against placebo over the area of Relapsing Remitting Multiple two years. a monoclonal Sclerosis (RRMS) continued with an antibody shown extension to the CFTY720D2301 protocol, An observational study on disability, quality to be effective an oral compound (FTY720) that revers- of life and cognition whilst on currently ibly traps a proportion of lymphocytes in approved treatment has been submitted to for treatment of the lymph nodes thereby reducing neuro- Ethics and approval is pending. multiple sclerosis. inflammation in RRMS. The core study finished earlier this year and the results are This oral product pending. Staff has a good safety Director of Neurology profile so far. The Another diverse treatment is Firategrast1 MK Robinson MBBS FRACP (GSK-SB-683699) (also oral) an antago- study will conclude nist of α4ß1/α4ß7 integrin mediated cell Senior Visiting Neurologist in 2010.” adhesion. These integrins have been shown GH Purdie MBBS FRACP to play an important role in the initiation KL Boundy MBBS FRACP and perpetuation of localised inflamma- H Waddy BMBS FRACP tion. Firategrast has a similar selectivity and pharmacodynamic activity to natalizumab, a Clinical Academic Neurologist / Director monoclonal antibody shown to be effective of Stroke Research Programme for treatment of multiple sclerosis. This oral SA Koblar BMBS FRACP PhD product has a good safety profile so far. The study will conclude in 2010. Senior Consultant Neurologist / Director of Stroke Unit The CAMMS323 and CAMMS324 protocols J Jannes BMBS FRACP PhD trial Alemtuzumab, a monoclonal antibody which is approved for the treatment of Chief Clinical Neuropsychologist B-cell chronic lymphocytic leukaemia in AC Kneebone BA Dip App Psych MA PhD FAPS many countries under the names CAMPATH or MabCAMPATH. In a phase II study Consultant Neurologist conducted in patients with RRMS, Alemtu- C Short BSc MBBS FRACP zumab produced a significant reduction in sustained accumulation of disability as well National Health and Medical Research as reductions in relapse rates and lesion Council (NHMRC) Stroke Fellow formation. CAMMS323 is for treatment- J Leyden BMBS naïve patients and CAMMS324 is for patients who have been on MS treatment. Principal Medical Scientist / Co-Director of Stroke Research Programme In the ATAMS Protocol 28063, Atacicept is MA Hamilton-Bruce BSc MSc MBA PhD AFCHSE used for RRMS in a double-blind, placebo- CBiol MSB CSci FIBMS controlled trial, with Rebif as a rescue treatment. Atacicept is a recombinant Medical Scientist fusion protein which acts as an antagonist MB Donk BHSc to B-lymphocyte stimulator (BLyS) and A Proliferation-inducing ligand (APRIL) which Chief EEG Technologist are important regulators of B cells. The J Pruszkowski Diploma in Medical Analysis treatment has been terminated due to poor efficacy and patients are on an extended Neurology Secretary follow-up period. JA D’ordoy Cert IV Bus Admin
Protocol EFC105031 trials an oral Administrative Assistant compound (Teriflunomide) which inhibits K Greet
TQEHresearch Research Report 2009 48 Administrative Assistant (part-time) Clinical Research Trials R Richards JA Deimel RN BN EL Lam RN Memory Unit Secretary PCK Cheung RN G Searle P Steventon RN S Casey RN BN Clinical Nurse Manager F Whaley RN BN KJ Webb RN BN Senior Research Scientist for SRP and Comprehensive Epilepsy Program CPC CIDR S Horn CPC ICU Cert M Lewis PhD
Stroke Nurse Senior Medical Scientist for SRP L Dodd RN BN AG Milton BSc(Hons) Dip Comp Sci
Transient Ischaemic Attack (TIA) Nurse P Toner RN BN
Stroke Research Nurse S Castle RN BN
Postgraduate Students Completed thesis EA Goble BSc(Hons) MSc, University of Adelaide, School of Medicine, July 2009. Thesis: Acetylcholine and Post-traumatic Stress Disorder”
PhD candidates M Djukic BHSc(Hons) GradCertBus(Acc) “Proteomic and genomic investigations in transient ischaemic attack” A Lam BPharm(Hons) “Endothelial Function in Cerebral Small Vessel Disease (SVD)” WK Leong BSc(Biotech)(Hons) “Mechanisms of neuroregeneration post-ischaemic stroke – stem cell and molecular studies” E Leung MBBS BSc(Med) DCH FRACGP “That a community-based approach to Transient Ischaemic Attack (TIA) care is effective”
Honours candidate V Krawczyk BSocSci “A case study of medical scientific searchers: Exploring communities of practice and understandings of language, medicine and the body”
TQEHresearch Research Report 2009 49 Grants 2009-2011, Wormald PJ, Koblar SA, Lang C, Alzheimer’s Australia. Scholarship to attend Lester S, Rischmueller M, Tan LW, Zalewski P. the Alzheimer’s Australian National Confer- ence June 2009 ($500 2009) Boundy KL, University of Adelaide. Australian Postgrad- Deimel J. uate Award ($17,024 2009) Djukic M.
Australian Neurology. (Research grant) University of Adelaide. Australian Postgrad- ($20,000 2009) Koblar SA, Hamilton-Bruce uate Award ($20,429 2009) Leung E. MA, Lewis M. University of Adelaide. Centre for Stem Cell Australian Neurology. (Research grant) A Research Robinson Institute. Efficacy of rodent model of ischaemic stroke ($6,000 intravenous versus intracerebral injection of 2009) Koblar SA, Lewis M, Hamilton-Bruce A, stem cells for brain repair ($75,000 2009) Milton A, Leong WK. Koblar SA, Gronthos S.
Catholic Archdiocese of Sydney.(Adult Stem University of Adelaide. Adelaide Scholarships Cell grant) Human Dental Pulp Stem Cells International (ASI) ($20,429 2009) Leong WK. for Stem Cell Therapy in Stroke ($100,000 2008/9) Koblar SA, Gronthos S, Arthur A. University of Adelaide. Faculty of Health Sciences. Postgraduate Research Scholarship CMV. Equipment Grant. ($14,500 2009) ($20,429 2009) Lam AK. Milton AG, Hamilton-Bruce MA, Jannes J, Koblar SA. University of South Australia. High Achiever Research Vacation Scholarship 2010 awarded National Stroke Foundation. (Research grant) 2009. ($1,800 2009) Krawczyk V. ($20,000 2009) Leung E.
NHMRC. (Project grant) The Role of Award Eph/ephrin Interactions in Mediating Leong WK. University of Adelaide School of Mesenchymal Stem Cell Commitment, Molecular and Biomedical Science, 1st Prize - Migration and Bone Fracture Repair Open Science Category Award ($200 2009) ($185,500 2009) 2009-2011, Gronthos S, Koblar SA, Matsuo K. Patents Janssen Cilag. Prime Database Survey Mutation associated with strokes (TPA): ($80,000 2007 - ongoing) Boundy KL. • Registered in the name of The Queen Elizabeth Hospital Research Foundation Stroke Genetics. (Collaborative Project grant) and Adelaide Research and Innovation Genome-wide association study ($1,100,000 Pty Ltd (ARI). Licensed to Atherogen 2009) Levi C, Sturm J, Attia J, Scott R, Koblar Biotechnology Pty Ltd. SA, Lincz L. • Inventors: Jannes J, Koblar SA, Hamilton- Bruce MA. Stroke SA. Stem Cell Therapy in Stroke • PCT/AU2004/000905 and issued patents ($10,000 2009) Koblar SA. derived there from including US Patent 7,455,970 and Australian Patent TQEH Research Foundation Honours Research 2003903412. Title: “Mutation associated Scholarship ($4,000 2009) Krawczyk V. with strokes. Inventors: Hamilton-Bruce MA; Jannes J, Koblar SA. TQEH Research Foundation. Postgraduate Top-Up Scholarship ($4,166 2009) Brain Repair Following Stroke - Stem Djukic M. Cell Ikaros Assay: Patent: An assay for determining neuroplasticity effect of stem TQEH Research Foundation Strategic Initia- cells PCT/AU02/01759. tives Funding. (Program grant) Inflamma- • Applicant: ARI, University of Adelaide tory Mechanisms and Therapies in Chronic and Medvet Science Pty Ltd. Disease, Asthma, COPD, Stroke, Cerebrovas- • Inventors: Koblar SA, Gronthos S, Arthur A. cular Disease, Rheumatology Diseases and • Australian Provisional Patent Applic. Chronic Rhinosinusitis. ($180,000 2009) No.2007904700 filed 30/8/07.
TQEHresearch Research Report 2009 50 NUCLEAR MEDICINE UNIT Research Focus • Statistical parametric mapping of regional cerebral blood flow and MRI • Development of new image processing techniques in brain and lung imaging • Evaluation of ischaemia and cardiac denervation in heart failure • Nuclear Medicine therapies in patients with inoperable cancers Dr Steve Unger
Overview of new imaging software for specialised “We found Our Department’s research continues to clinical diagnosis. This was performed by Dr involvement of focus on the major areas of cardiac, Barnden and a grant-funded scientist. oncological and neurological nuclear brainstem and medicine. Dr Thanh Nguyen is investigating The powerful statistical parametric mapping prefrontal white the association between cardiac sympathetic (SPM) package was applied to subjects denervation (as assessed by myocardial selected retrospectively from the depart- matter structures I-123 MIBG imaging) and myocardial ment’s archive of dementia brain scans. not yet reported in ischaemia (assessed with stress Tc-99m Together with new pre-processing software the CFS literature. Sestamibi imaging) and outcomes, particu- developed at TQEH and in collaboration larly ventricular arrhythmias, in patients with with Dr David Abbott of the Brain Research We presented heart failure. We are also involved in cardiac Institute (BRI) in Melbourne, this revealed preliminary results “hot spot’ imaging of patients with an acute perfusion deficits in the anterior cingulate sympathetically medicated cardiac syndrome gyrus in Mild Cognitive Impairment. to an international known as Tako-tsubo cardiomyopathy. CFS conference Interim funding was obtained to allow our We have also participated in two multi- grant-funded scientist to continue analysis in March.” centre collaborative projects with the of brain MRI images in Chronic Fatigue oncology unit involving therapeutic nuclear Syndrome (CFS) in a project with Dr Richard medicine. The first study involves the use Burnet of RAH as principal investigator. Our of SIR-spheres (microspheres labelled with application of SPM for quantitative analysis Y-90) administered via the hepatic artery in of T1 and T2-weighted MRI is a world first. patients with non-resectable liver metastases We found involvement of brainstem and from primary colorectal carcinoma. The prefrontal white matter structures not yet second study is a large multi-national multi- reported in the CFS literature. We presented centre Phase III trial of targeted radiation preliminary results to an international CFS therapy using Alpharedin (radium-223) in conference in March. patients with metastatic prostate cancer and diffuse bone pain. New image processing programs have been developed by Dr Barnden for clinical During 2009, Dr Gabrielle Cehic has evaluation. They offer improved detection successfully set up a state-wide collabora- of pulmonary emboli and cerebral blood tive referral and therapy service for patients flow deficits. Dr Vallat has utilised the with gastro-enterological/pancreatic neuro- new program to evaluate SPECT (3-D) lung endocrine tumours (GEP-NET), chairing images in comparison to standard planar regular multi-disciplinary meetings on a images in the diagnosis of pulmonary bi-monthly basis. We hope to commence embolism in a prospective clinical study. clinical trials of novel radio-labelled peptides in these patients with poorly controlled The masters research project “Acetycholine symptoms in the near future. and Post Traumatic Stress Disorder” of Elizabeth Goble jointly supervised by Dr Neuroimaging research and development Barnden was completed and accepted. in 2009 built on the image processing expertise of the department. It involved two clinical brain research projects and the in-house development and application
TQEHresearch Research Report 2009 51 Staff Director S Unger MBBS FRACP PhD
Visiting Medical Specialists M Kitchener MBBS FRACP R Casse MBBS FRACP A Warner MBBS FRACP PhD G Cehic MBBS FRACP K Tan MBBS FRACP M Nottage MBBS FRACR
Medical Scientists L Barnden BSc(Hons)PhD D Badger BSc(Hons) PhD B Crouch BSc(Hons) A Menone BSc(Hons)PhD
Higher Degree Students PhD candidate TH Nguyen “Cardiac Denervation in Heart Failure”
MSc in Medial Physics D Badger B Crouch
Registrar W Vallat MBBS
Technologists P Ong G Pandos T Smith P Sotiropoulos N Farnham T Piscitelli K Eberhard L Waran R Edwards Grants D Maglica The Mason Foundation. Investigation of the progression of brain abnormalities in Chronic Fatigue Syndrome (CFS) using MRI in a longitudinal study of post-viral fatigue subjects ($100,000 2009) 2009-10, Barnden L, Kwiatek R.
John T Reid Charitable Trusts. Investigation of the progression of brain abnormalities in CFS using MRI in a longitudinal study of post-viral fatigue subjects. ($51,000 2009) 2009-10, Barnden L, Kwiatek R.
TQEHresearch Research Report 2009 52 TQEHresearch Research Report 2009 53 NURSING RESEARCH Research Focus • Diabetes • Cardiac Assessment • Cardiac Care • Advanced Care Planning • Wound Care • Education
“The application of Overview Grants evidence/research The past year has provided many challenges Abbott Diabetes Care Service Development for The Queen Elizabeth Hospital/Saint Grant for Diabetes Educators. Education and based protocols Margaret’s Rehabilitation Hospital and support for young people and their families and pathways Nursing however, the Nursing Service affected by type 1diabetes in rural and continued its endeavours to improve remote SA ($3,000 2009) Visentin K, Giles J. continue to be health outcomes for its patients through implemented...” the continuum of inpatient, day patient, The Northern Communities Health Founda- outpatient and community services. The tion Inc. Advance Care Planning in the continuing development of Clinical Practice Community ($10,000 2009) 2007-2009, Consultants toward Nurse Practitioner authori- Respecting Patient Choices Program TQEH sation promotes the value Nurses bring to the and Adelaide Western General Practice care continuum and transitioning patients Network. back to community services and aiding patients to self manage their chronic disease/ illness. The application of evidence/research based protocols and pathways continue to be implemented enabling outcomes to be evaluated and further research undertaken. Nurses participated in clinical practice improvement studies for continence manage- ment reduction in medication omissions, security outcomes for patients in ED and the establishment of an evidence based Warfarin protocol for the hospital.
Further collaboration is underway with the University of Adelaide – Nursing Programmes to progress areas of clinical significance for 2010.
TQEHresearch Research Report 2009 54 OTOLARYNGOLOGY, HEAD AND NECK SURGERY, Department of
Professor PJ Wormald
Overview involved with other research teams at the 'This group in In 2009 the ENT Department continued Institute in the investigation of inflamma- to expand its research capabilities and tory mechanisms and in the development combination with research team. We now have six full time of potentially interesting new treatment the supervising PhD students and a Master’s student as well options. Our involvement in Chronic as three full time scientists. This group in Inflammatory Diseases Research (CIDR) clinical staff has combination with the supervising clinical has seen our expertise utilized by other developed a very staff has developed a very vibrant critical researchers within the BHI. research mass which generates ideas and vibrant critical is consequently able to stay at the very The Tan & Wormald NHMRC Development cutting edge of rhinological research Grant using the S. aureus biofilm model in research mass which worldwide. This has led to our department sheep commenced in March 2009. Dr Tan, generates ideas being recognized internationally as one of Ms Leonie Baker (Senior Research Assistant) the leading rhinological research institu- and Ms Sarah Bray (Research Assistant) and is consequently tions in the world. At the recent American were involved in testing the inhibitory effect able to stay at the Rhinological Society meeting in San Diego of the novel sugar 3 sialyl lactose (3SL) on our department was awarded the Maurice biofilm formation. We also conducted in very cutting edge of Cottle Award for the best scientific paper vitro tests of the efficacy of 3SL on other rhinological research and the Golden Head Mirror Award (an clinically relevant bacteria, Haemophilus award that is not given each year but only influenzae and Pseduomonas aeruginosa. worldwide... when the board deems suitable individuals fill the criteria) for a significant contribu- Dr Andrew Foreman, Surgeon Scientist tion to Rhinology both in the research and PhD candidate, is investigating the role teaching areas. of biofilms in Chronic Rhinosinusitis. So ...This has led to far he has developed a Fluorescence in The Queen Elizabeth Hospital Research situ Hybridisation (FISH) protocol for the our department Foundation has supported the purchase of detection and characterisation of bacterial being recognized a number of new instruments to support and fungal biofilms in CRS and compared research in the Basil Hetzel Institute. The this protocol to our gold-standard BacLight internationally as Bioplex MultiArrayer (Biorad, USA), Liquichip protocol to identify situations in which each one of the leading (Qiagen, Germany), and ImmunoCAP would be best used, based on the research (Phadia, Sweden) have greatly increased aims of the project. Over the last year rhinological research our capacity to perform highly sophisti- he has successfully identified an interac- institutions in the cated analyses of cytokine protein markers tion between S. aureus biofilms and the of inflammation, bacterial quantitation host. This has been in collaboration with world.” on ex vivo animal respiratory mucosa and the University of Ghent, Belgium, whom immunoglobulin profiles in patient sera Andrew visited earlier in the year. This is the and tissues. The ENT Department has also first study to definitively link biofilms to the been a central player in the development pathogenesis of CRS and therefore validates of the “Centre for Chronic Inflammation our previous work as well as providing a and Disease Research” (CIDR). A successful basis from which to move forward from collaborative research bid involving ENT, with more specific biofilm treatment Stroke Research Programme, Rheuma- modalities. Andrew’s research also collabo- tology and Respiratory centered on the rates with the Centre for Genomic Sciences common theme in each of these areas, (CGS) in Pittsburgh, PA, USA. This aspect namely “inflammation”. This successful bid will attempt to perform whole genome has now seen our research team become sequencing of S. aureus strains to identify
TQEHresearch Research Report 2009 55 “...the next differences between biofilm-forming and Staff non biofilm-forming strains and how these Professor of Otolaryngology and Head important step is might be relevant to CRS pathogenesis. of Department to evaluate the Andrew also visited the CGS whilst in the P-J Wormald MD FCS(SA) FRCS(Ed) role of fungus in USA where he presented at the American Rhinologic Society Annual Scientific Senior Lecturer non-sensitized as Meeting. G Rees MBBS FRACS well as sensitized Dr Rowan Valentine, Surgeon Scientist Staff Specialist subjects and to PhD candidate, is investigating the effects S Floreani MBBS FRACS understand the of chitosan on the nose and sinuses after J Ling MBBS FRACS pathogenesis surgery. This year he has completed a S Rajapaksa MBBS FRACS patient trial comparing the effects of this H Pant MBBS FRACS of fungal sinus gel on haemostasis and adhesion formation, infections as well showing the gels significant anti-adhesion Rhinology Fellow and haemostatic properties. In addition M Tewfik MD as the potential to this, Rowan has recently developed an symbiosis between animal model of carotid artery injury during ENT Registrar endoscopic sinus surgery and is currently K Ha MBBS MS fungus and bacterial further analysing the CD gel haemostatic infections properties under this challenging environ- Garnett Passe & Rodney Williams particularly S. ment. Next year we will be continuing to Memorial Foundation Research investigate CD Gel by investigating the Scientist, University of Adelaide aureus.” haemostatic mechanisms by which CD Gel LW Tan BSc(Hons) PhD achieves haemostasis, and further delineate the effects of the gel on sinus ostial stenosis ENT Research Assistants following sinus surgery. L Baker BSc(Hons) S Bray BSc(Hons) Dr Sam Boase, PhD student, is developing an animal model of fungal sinusitis. The Clinical Nurse Operating Theatres department has successfully developed T Nicholls RN BN MN a bacterial model, the next important step is to evaluate the role of fungus in Secretary non-sensitized as well as sensitized subjects L Martin and to understand the pathogenesis of fungal sinus infections as well as the potential symbiosis between fungus and bacterial infections particularly S. aureus.
Dr Josh Jervis-Bardy, PhD candidate, has been investigating the role of S. aureus in the recalcitrant chronic sinusitis patients as well as investigating novel and new treatment of patients with recalcitrant S. aureus infections.
Dr Deepti Singhal, PhD candidate, has developed the first pictures of fungal biofilms both in a static as well as in the flow chamber and been able to characterize the features of fungal biofilms for the first time in the world.
Ms Jasmine Micklen is doing a PhD, evaluating the validity and acceptability of currently accepted quality of life question- naires on the outcomes of aboriginal patients treated for head and neck cancer.
TQEHresearch Research Report 2009 56 Postgraduate Doctoral Students Completed thesis T Le MS, University of Adelaide, Discipline of Surgery, School of Medicine. Thesis: “The effect of topical agents on biofilm formation in the in vivo sheep model of chronic rhinosinusitis”
Continuing Postgraduate students R Valentine MBBS “Comparison of Tranexamic Acid and Chito-dex Gel in Haemostasis and Wound Healing following Endoscopic Sinus Surgery”
A Foreman MBBS “The role of bacterial bioflims in chronic rhinosinusitis”
S Boase MBBS “Bacterial biofilm formation in chronic rhinosinusitis: testing novel treatments using a sheep model”
D Singhal BMBS “Fungal bacterial Biofilms in chronic rhinosinusitis”
J Jervis-Bardy MBBS “Novel anti-biofilm therapies in chronic rhinosinusitis”
J Micklen BBTech(Hons) “Australian Aboriginal Head and Neck Cancer Patients: Health-Related Quality of Life in South Australia and the Northern Territory”
Awards Grants A Foreman. Australian Society of Otolaryn- BioInnovation SA. (Commercial Develop- gology Head and Neck Surgery SA Branch ment grant) Novel glycotherapies for Meeting, Adelaide, Ronald Gristwood Medal bacterial biofilm associated diseases for Best Registrar Presentation, August 2009. ($62,420 2009) Tan LW, Wormald PJ.
A Foreman. The Queen Elizabeth Hospital Garnett Passe and Rodney Williams Memorial Research Foundation Research Day Adelaide, Foundation. The nasal innate immune Best presentation, “Higher Degrees Clinical response to fungal and staphylococcal and Registrars” category, October 2009. challenge: the role of lysozyme ($90,000 2009) 2008-2010, Carney AS, Harris P, A Foreman. Royal Australasian College Woods C, Ooi EH, Tan LW, Wormald PJ. of Surgeons Surgical Research Society, 46th ASM, Adelaide, Travel Grant, Garnett Passe and Rodney Williams November 2009. Memorial Foundation. (Research Scientist grant) Are aberrant sugar profiles of the R Valentine. American Rhinologic Society, San mucin glycoprotein MUC7 responsible for Diego CA, USA. Maurice Cottle Award, Best bacterial and fungal biofilm formation in Scientific Presentation, September 2009. chronic rhinosinusitis ($120,000 2009) 2008-2011, Tan LW, Wormald PJ. PJ Wormald. American Rhinologic Society, San Diego CA, USA. Golden Head Mirror Garnett Passe and Rodney Williams Award for Significant Contribution and Memorial Foundation. (Surgeon Scientist Teaching in ENT, September 2009. grant) ($75,000 2009) Foreman A.
Garnett Passe and Rodney Williams Memorial Foundation. (Surgeon Scientist grant) ($75,000 2009) Valentine R.
Premier‘s Nursing & Midwifery Scholarship 2009/2010. A Study Tour to the United States of America and the United Kingdom to explore the fundamentals in developing the ENT Nurse Practitioner role. ($12,000 2009) Nicholls T.
TQEHresearch Research Report 2009 57 TQEH Research Foundation Strategic Initia- tives Funding. (Program grant) Inflamma- tory mechanisms and therapies in chronic disease-asthma, COPD, stroke, cerebrovas- cular disease, rheumatology diseases and chronic rhinosinusitis ($180,000 2009) 2009-2011, Wormald PJ, Koblar S, Rischmueller M, Lester S, Lang C, Tan LW, Zalewski P.
TQEH Research Foundation/ENT Department Postgraduate Research Scholarship ($20,427 2009) Singhal D.
TQEH Research Foundation/ENT Department Postgraduate Research Scholarship ($18,724 2009) Jervois-Bardy J.
The University of Adelaide Faculty Health Sciences New Appointment Funding 2009. Commercialisation of a glycoprofiling diagnostic kit and novel therapies for biofilm related respiratory disorders ($15,000 2009) Tan LW.
Commercialisation Patents PCT filed Diagnostic Method-Registered in the name of TQEH Research Foundation and TQEH: Australian Provisional Patent Application 2008902510 Filed 21 May 2008; PCT filed 31 Mar 2009 (Ref no. SPEC-11809049). Inventor: LW Tan. Officially published on 26 November 2009 under publication number WO 2009/140715.
Method of treatment-Registered in the name of TQEH Research Foundation and TQEH: Australian Provisional Patent Application 2008903259 Filed 26 June 2008; PCT filed 26 June 2009 (Ref no. SPEC-12095484) Inventor: LW Tan.
TQEHresearch Research Report 2009 58 PSYCHIATRY, University of Adelaide Discipline of
Research Focus • The relationship between depression and cardiovascular disease and its management. • The development of more efficient and effective strategies for the management of mental illness.
Dr Geoff Schrader
Overview in depressed outpatients at the Centre for In 2009, patients began to be recruited for the Treatment of Anxiety and Depression. a randomised controlled trial of omega 3 Rachel Dreyer began a project which will fatty acids for depression in patients with examine gender effects in the presentation ischaemic heart disease. The trial is part and management of cardiovascular disease. of a project funded by the National Heart Tracy Air began a project which will examine Foundation and beyondblue which is also the impact of depression on the cost to the investigating possible mechanisms including community of cardiovascular disease. the role of the serotonin transporter gene and endothelial dysfunction on any impact Dr Rohan Dhillon, Dr Tarun Bastiampillai and of omega 3 fatty on depression. Dr Jorg Strobel and Ms Sue Tiver continued to develop their interest in new approaches Dr Schrader continued his collaboration to the management of mental illness. In with Professor Simon Stewart, Professor of particular they assessed the impact of a Preventative Cardiology at the Baker Heart novel means of improving communication Research Institute and Professor David between mental health professionals. Dr Wilkinson, of the Department of Primary Maura Kenny, clinical lecturer, continued to Care at University of Queensland on the develop her interest in mindfulness based NHMRC funded “TakeHeart” project. This cognitive psychotherapy at the Centre for project involves a cluster randomized trial the Treatment of Anxiety and Depression. conducted in twenty four general practices and is attempting to discover the impact of identifying and treating depression in patients with heart failure and angina completed its recruitment phase this year. Dr Schrader has also continued his collabo- ration with A/Prof John Beltrame from the Discipline of Medicine and together they supervise four PhD students, Rosanna Tavella, Alexis Wheeler, Rachel Dreyer and Tracy Air whose projects focus on various aspects of the association between cardiac disease and depression. Rosanna Tavella continued her investigation into the impact of depression on quality of life in cardiac patients and continued a project examining the association between the serotonin transporter gene and depression in cardiac patients. Alexis Wheeler continued a project examining mortality rates in cardiac patients with depression and this work is being carried out in association with the Epidemiology Branch of the SA Health. She began recruiting patients for a study to determine the effect of mindfulness based meditation on heart rate variability
TQEHresearch Research Report 2009 59 Staff Senior Lecturer GD Schrader MBBS PhD FRANZCP
Research Fellow K Eckert MPH
Research Nurses E Jansen RN T Stewart RN L Burres RN
Administration D Alberton
Postgraduate Students PhD candidates R Tavella “Quality of life, depression and cardiac disease” A Wheeler “Associations between depression and cardiac disease” R Dreyer “Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction (AMI) – Patients. The VIRGO Study”
T Air “The economic impact of depression in cardiovascular disease”
Grants National Heart Foundation of Australia/ Beyondblue.Omega-3 fatty acid supple- mentation for symptoms of depression in cardiovascular disease. ($222,500 2009) 2008-2010, Schrader GD, Beltrame J, Howe P, Berry N, Coates A, Buckley J.
TQEH Research Foundation/University of Adelaide. (Postgraduate Scholarship) ($20,427 2009) Wheeler A.
TQEHresearch Research Report 2009 60 RENAL UNIT Research Focus • Many aspects of the care of patients with renal disease with special emphasis on kidney transplantation at clinical, epidemiological and experimental levels • A new research initiative began in 2005-6 continues in the field of pancreatic islet transplantation as treatment for Type-1 diabetes mellitus and has progressed to the point where the first islet transplant is imminent • A three year TQEHRF Program Grant to establish the renal unit as a centre for renal translational research to bring areas of research into the clinical arena for the benefit of renal transplant patients
Professor Graeme Russ
Overview “Increasingly we 2009 has again been an extremely productive year for research in the department. have been able The highlights of the year have been: to perform more • Associate Professor Manchala Mohan Rao was installed as a Member of the Order difficult transplants, of Australia (AM) in the Queen’s Birthday Honours List for his service to medicine, particularly renal transplant surgery, as a mentor and educator, and through transplanting six professional development. In addition A/Prof Rao received a ‘Lifetime Achievement recipients with ABO Award’ from the Indian Society of Organ Transplantation in recognition of his role for incompatibility and pioneering renal transplantation in India; five who required • Ongoing funding from the Juvenile Diabetes Research Foundation for the Pancreatic Islet Transplant Project; desensitisation to antibodies who • Research funding to the department exceeding well over 1 million dollars, for the fourth consecutive year; otherwise may not • Fifty publications (well over a 100% increase from last year) in peer reviewed have been international medical journals; considered for • A record number of both post graduate students and honours’ students for the a transplant.” second year in a row; • Three post graduate students awarded their PhD degree; • Five Honours Students being awarded Honours in BSc Honours Degree; • Continuing growth in contract research between commercial companies and the department; • A new three year NHMRC Project Grant to A/Prof Toby Coates for Renal Dendritic Cell studies; • TQEHRF Program Grant for Translation Renal Research Centre to Prof Graeme Russ, A/Prof Toby Coates, A/Prof Stephen McDonald, Dr Ravi Krishnan, A/Prof Ray Morris and Dr Betty Sallustio.
The research program at the Department of Nephrology and Transplantation Services at The Queen Elizabeth Hospital has three broad aims which cover firstly the epidemi- ology of kidney disease, cellular therapies for chronic renal disease/organ transplanta- tion and clinical renal transplantation research. The department had another good year for kidney transplantation, with eighty kidney transplants, which included twenty three with live donors. Increasingly we have been able to perform more difficult transplants, transplanting six recipients with ABO incompatibility and five who required desensitisation to antibodies who otherwise may not have been considered for a transplant.
TQEHresearch Research Report 2009 61 Epidemiological Research Laboratory Research The principal focus of Epidemiological The laboratory research conducted by Dr Ravi Research has continued to be the Australia Krishnan continues to investigate the role of and New Zealand Dialysis and Transplant inhibitory molecules in allograft rejection by (ANZDATA).and ANZ Organ Donor (ANZOD) the use of gene therapy vectors. The inhibi- Registries, conducted within the Depart- tory molecules studied are FoxP3, HLA-G, ment. A/Prof McDonald is the Executive PD-L1/2. Another aspect of Dr Krishnan’s Officer for ANZDATA, and Prof Russ for work examines the role of adult Mesenchymal ANZOD. These are now funded by the stem cells as cellular therapeutic agents National Organ and Tissue Donation and for modifying the alloimmune response to Transplantation Authority; operations of facilitate the acceptance of transplanted each are overseen by separate steering organs with minimal immunosuppres- committees. sion. In addition, new investigations using mesenchymal stem cells by Dr Krishnan have For both Registries, the core roles are recently been funded by the US-based Adult gathering and utilizing information about Stem Cell Therapy Company, Angioblast the incidence, prevalence and outcomes of Systems. The collaborative research project “The collaborative dialysis and transplantation across Australia will be examining the role of Adult Stem and New Zealand (for the ANZDATA Cells in a variety of degenerative diseases research project Registry), and the number and characteris- and opens up a strong link between medical will be examining tics of deceased organ donors (for ANZOD research in the hospital and industry. The Registry). funding will allow the employment of experi- the role of enced researchers Mr Dongqing Yang and Adult Stem Cells As part of this there is an active research Ms Julie Johnston. The data obtained from in a variety of role, with a number of papers produced the studies will facilitate further funding from and a wide network of collaborators in renal Industry and also Category 1 type funding. degenerative units throughout Australia. In 2009, over This year Dr Krishnan has supervised PhD diseases and opens thirty journal publications appeared based student, Boris Fedorić who was awarded his on ANZDATA or ANZOD data. In addition, PhD in October, along with four honours up a strong link major changes have been undertaken to the students (Miranda Coleman, Tim Searcy, between medical content and format of the individual centre James Cooney and Chris Hope). Dr Krishnan reports. These are reports which outline has pursued extensive collaborations at an research in the the performance of individual renal units international level with the University of hospital throughout Australia and New Zealand in Columbia (Prof Silviou Ietescu) and local and industry.“ the areas of transplantation and dialysis, collaborators with regard to mesenchymal and are produced for every unit on a yearly stem cell therapy. basis. Finally, there has been extensive collaboration with and use of ANZDATA TQEH Research Foundation continues to data by the Australian Institute of Health support the laboratory research effort. In and Welfare who have produced a series of 2009 the Foundation initiated a Program major reports on chronic kidney disease in Grant for the Renal Unit to create a centre for Australia. renal translational research. The Foundation also continued to support small grants which Dr Andrew Brunskill resigned as Epidemi- assisted Dr Michael Collins and Dr Matthew ology Fellow in September, and will return Stephenson with their studies in renal to the US. Highlights of his period as transplantation. fellow have been the exploration of socio- economic dimensions of end-stage renal During the year Dr Michael Collins instigated disease. Hannah Dent is on maternity leave a major study of ‘screening for colo-rectal from November 2009; the biostatistician cancer in kidney transplant recipients’. This position is being filled by Fiona Mensah. study is ongoing and the initial data looks very promising in the management of transplant recipients. Michael has also commenced his PhD studies into tolerogenic dendritic cell therapy in renal transplantation under the supervision of A/Prof Toby Coates and Prof Graeme Russ. Within the dendritic cell laboratory Dr Natasha Rogers continued
TQEHresearch Research Report 2009 62 her studies on tolerogenic liposomes in in crossmatching. Ms Eng was awarded “Organ donors in association with Prof Chris Parish from the her PhD degree during 2009 and is now Australian National University. Dr Claire Jessup benefiting from her post doctoral research South Australia has worked on a novel approach to cellular at the John Hopkins’ Hospital in Baltimore. continue to allow therapy by researching the characteristics of During 2009 other members of the Tissue SANTIP to contribute rat endothelial progenitor cells to enhance the Typing Laboratory presented clinical engraftment of pancreatic islets. Dr Matthew research at the Australasian South East a high number of Stephenson has joined our research team Asian Tissue Typing Association meeting in pancreata for islet studying the effects of how ischaemia of the New Delhi and at the American Society for kidney affects its function. Dr Stephenson Histocompatability and Immunogenetics in isolation and a along with Dr Duncan Cooke investigated San Francisco. further six organs dendritic cell markers in urine of kidney transplant recipients to examine patients South Australian and Northern for whole pancreas undergoing acute rejection. Ms Svjetlana Territory Islet Program transplantation.” Kireta commenced studies into mesangial The South Australian and Northern Territory cells isolated from nephrectomised kidneys Islet Program (SANTIP) was extremely to examine their role in transplant glomeru- active this year in sending organs from lopathy. Dr Shilpa Prasad, Hooi Sian Eng and South Australia and the Northern Territory Boris Fedoric all completed their PhDs and to St Vincent’s Institute in Melbourne for we congratulate them all, along with their islet isolation. Dr Daisy Mohanasundaram supervisors A/Prof Toby Coates, Professor continued with her expertise in rodent islet Graeme Russ and Dr Ravi Krishnan. isolation in mice and rats. She has initiated a project in Type II diabetes to investigate Dr Shaundeep Sen continues his PhD the role of critical zinc transporters in islet examining the relationship between risk biology. Ms Clare Mee has also utilised her factors and markers of vascular disease among expertise in small animal handling in isolation people with kidney disease under the supervi- of islets from rodent pancreata. Mr Chris sion of A/Prof Stephen McDonald and A/ Drogemuller has developed a unique model Prof Toby Coates, in addition to Dr Claudine of testing the variability of zinc transporter Bonder from the Hanson Institute. In 2009, gene expression in isolated human islets. Dr Sen’s work has included assays of endothe- Chris, together with Dr Claire Jessup and lial progenitor cell number and function, A/Prof Toby Coates supervised Ms Amy for application in clinical studies in dialysis Hughes to develop adenoviral gene therapy and transplant patients. He has continued as a novel therapy to prevent apoptosis in to examine the rates of different types of transplanted islets. Amy was awarded a hospital admissions for cardiovascular causes, prestigious Trevor Prescott scholarship to comparing rates of myocardial infarction and assist in her PhD studies. SANTIP is prepared cardiac failure between dialysis and transplant and is eagerly waiting to perform its first patients and the general population. clinical transplant, after being at the brink of an islet transplant six times during 2009. Professor Graeme Russ was successful in being awarded a Cellcept Australia Research Mr Clyde Milner continues to provide labora- Grant (CARG) for his study on the correla- tory supervision and management on the tion of renal donor histopathology and Islet Transplantation Program, while Islet function with long-term outcome in recipi- Transplant nurse Ms Toni Miller has coordi- ents of expanded criteria deceased donor nated the transplant list. Four patients are organs: derivation of donor score which on the active waiting list and are being predicts likelihood of outcome events. constantly monitored in a new clinic at the Royal Adelaide Hospital conducted by A/ Dr Shilpa Prasad was awarded her PhD Prof Toby Coates and endocrinologist A/Prof degree this year using a novel transplant David Torpy. Organ donors in South Australia model studying the immune biology in continue to allow SANTIP to contribute a the common marmoset monkey. Tissue high number of pancreata for islet isolation typing research continued in the labora- and a further six organs for whole pancreas tory under the supervision of A/Prof Toby transplantation. The program will gain a Coates and Prof Graeme Russ. Ms Hooi second PhD student starting in 2010 to study Sian Eng finalised her studies on the the role of zinc transporter gene expression significance of Luminex detected antibodies in diabetes.
TQEHresearch Research Report 2009 63 Staff CJ Martin Fellow Professor and Director Renal Unit and C Jessup PhD Renal Transplant Services GR Russ MBBS FRACP PhD Research Assistants A Hughes BSc(Hons) Senior Staff Nephrologists N Brook BSc MSc BM MRCS MD FRCS (Urol) Technical Officers RP Carroll MB BCh MA FRACP J Johnston R Chacko MD DNB DM(Nephro) DNB FRACP D Yang MSc APS Disney MBBS FRACP SP McDonald MBBS(Hons) FRACP PhD Clinical Trials B Hockley RN Transplant Surgeons C Russ RN MM Rao BSc MS MCh FACS FRACS AM M Hockley RN CH Russell MB BCh FRACS BA(Hons) MA (Oxon) K Fisher FRCS (Edin) L Trowbridge RN T Miller RN Renal Transplant Nephrologist C Chan RN PTH Coates MBBS FRACP PhD ANZDATA Registry Senior Medical Scientist L Excell R Krishnan BSc(Hons) PhD B Livingston B Surv E Steinmetz Medical Scientists C Young C Milner BAppSc C Leitch S Kireta BSc A Brunskill MBBS MPH C Drogemuller BSc (Epidemiology Fellow to Sept 2009) D Mohanasundaram PhD H Dent BSc(Hons) M Stephenson PhD F Mensah MSc C Mee BHlthSc A Milton BSc (part-time)
TQEHresearch Research Report 2009 64 Postgraduate Students Completed Theses S Prasad PhD, University of Adelaide, Department of Medicine. Thesis: “Studies of Immune Biology of the Common Marmoset: A Novel Non-human Primate Transplant Model” H S Eng PhD, University of Adelaide, Department of Medicine. Thesis: “Specificity and properties of Anti-HLA Antibodies Associated with Renal Allograft Rejection” B Fedoric PhD, University of Adelaide, Department of Medicine. Thesis: “Generation of Tolerogenic Human DC Through Rapamycin Conditioning and Genetic Modification with HLA-G”
Honours degrees M Coleman BHlthSc (Hons) First Class University of Adelaide. “T Cells Acquire Antigen Presenting Function From Dendritic Cells (DC): DC Modified With Immunosuppressive Agents Subvert T Cell Antigen Presenting Function”
T Searcy BBiotech (Hons) First Class Flinders University. “Human Mesenchymal Stem Cells Inhibit Monocyte-Derived Dendritic Cell Phenotype and Function”
J Cooney BBiotech (Hons) 2A Flinders University. “The Effect Of Ectopic FOXP3 Expression on Mesenchymal Stem Cell Function”
C Hope BBiotech (Hons) 2A Flinders University. “DNA Methylation of Adipogenic Genes in Mesenchymal Stem Cells during Adipogenic Differentiation”
R Yu BMedSc (Hons) First Class University of Adelaide. “Calcium supplementation and its effects on bone loss in renal transplant recipients”
Continuing Postgraduate Students N Rogers MBBS FRACP “Specific targeting of dendritic cells with tolerogenic liposomes in allotrans plantation”
M Collins MBChB FRACP “Tolerogenic dendritic cell therapy in kidney transplantation”
S Sen MBBS FRACP “Investigation of classical and novel risk factors for cardiovascular disease and function in kidney disease”
D Rojas BSc (Hons) “Studies on the immunomodulatory effects of the inhibitory molecule PDL-2 in dendritic cells”
T Matthews BSc (Hons) “Role of Dendritic Cells in Immune Responses in Ischaemia Reperfusion Injury in the Kidney”
A Hughes BSc (Hons) “Transduction of pancreatic islets with insulin-like growth factor–II for transplantation in the treatment of type-I diabetes”
Appointments C Milner Affiliate Lecturer, School of Medicine Faculty of Health Sciences, The University of Adelaide. M Stephenson Affiliate Lecturer, School of Medicine Faculty of Health Sciences, The University of Adelaide.
TQEHresearch Research Report 2009 65 “We appreciate the Grants TQEH Research Foundation. (Small grant CellCept Australia. (Research grant) (CARG). 2008) The ectopic expression of the generous support Correlation of renal donor histopathology and transcription factor FoxP3 in dendritic cells of the Muriel T function with long-term outcome in recipients ($20,000 2008-2009) Krishnan R. Gunn Foundation of expanded criteria deceased donor organs: derivation of donor score which predicts TQEH Research Foundation Strategic Initia- to enable enhanced likelihood of outcome events. ($20,000 2009) tives Funding. (Program grant). To institute work to continue in Russ G. a centre for renal translational research ($180,000 2009) 2009-2011, Russ G, the Renal Unit.” Juvenile Diabetes Research Foundation. Coates PTH, Krishnan R, McDonald S, (Program grant) South Australian and Morris RG, Sallustio B. Northern Territory Pancreatic Islet Isolation Program ($851,728 2008-2009) 2006 – TQEH Research Foundation/University of 2009, Russ G, Coates PTH, Morris R et al. Adelaide. (Divisional Scholarship) ($20,427 2009) Rojas DM. Juvenile Diabetes Research Foundation. Young scientist research travel grant ($2,500 2009) TQEH Research Foundation. Honours Jessup C. Research Scholarships ($16,000 2009) Coleman M, Cooney J, Yu R, Searcy T. Juvenile Diabetes Research Foundation. Young scientist research travel grant ($2,000 2009) TQEH Research Foundation. (Near Miss Rojas D. grant 2008). The role of renal dendritic cells in ischaemia reperfusion injury ($98,000 Kidney Health Australia. (Postgraduate 2008-2009) Coates PTH. Scholarship) Investigation of classical and novel risk factors for cardiovascular disease TQEH Research Foundation. (Small grant and function in kidney disease ($31,000 2009) Screening for colorectal cancer in 2009) 2007-2009, Sen S. recipients of kidney transplants ($10,000 2009) Collins M, Coates PTH, Teo E. NHMRC. (Capacity Building grant in Popula- tion Health) Improving population health by TQEH Research Foundation. (Small grant a multidisciplinary, multi-method focus on 2009) The role of Mesangial cells in kidney disease of the young, the old and of transplant glomerulopathy ($9,959 2009) Indigenous Australians (TQEH $54,970 2009) Stephenson M, Coates PTH, Kireta S. 2007-2010, Craig J, Cass A, Irwig L, Chadban S, McDonald S, Devitt J, Macaskill P, Jones M, Trevor Prescott/Freemasons Scholarship. Howard K. ($20,000 2009) 2009-2011, Hughes A.
NHMRC. (2009 Equipment grant) The role University of Adelaide. Overseas Conference of renal dendritic cells in infection under Scheme ($1,500 2009) Jessup C. immunosuppression. ($11,848 2009) Coates PTH, D’Andrea R. Contract research NHMRC. (Postgraduate Medical Scholar- Angioblast Systems Ltd. Studies on the ship) Tolerogenic Dendritic Cells in Kidney therapeutic use of adult mesenchymal stem Transplantation: studies in Common cells in degenerative diseases ($192,000 Marmoset Monkeys ($32,628 2009) 2008-2009) Krishnan R. 2009-2011, Collins M.
NHMRC. (Postgraduate Medical Research Scholarship) Specific targeting of dendritic cells with tolerogenic liposomes in allotransplanta- tion ($32,628 2009) 2008-2010, Rogers N.
NHMRC. (Project grant # 565033) The role of renal dendritic cells in infections and immunity under immunosuppression ($152,125 2009) 2009-2011, Coates PTH.
TQEHresearch Research Report 2009 66 Awards R Carroll Mark Cock’s Award from the TSANZ and TeamLife Transplant Australia. M Collins TQEH Research Day 2009. Winner Best Lay description. $500. A Hughes Trevor Prescott Scholarship 2009-2011 $20,000. A Hughes TSANZ Scientific Meeting Awards - Young Investigator Award. C Jessup Overseas Conference Scheme, University of Adelaide - $1,500. C Jessup Young Scientist Research Travel Grant, JDRF - $2,500.
MM Rao AM Member of the Order of Australia – Queen’s Birthday Honour. For service to medicine, particularly renal transplant surgery, as a mentor and educator, and through professional development.
MM Rao AM ‘Lifetime Achievement Award’ by the Indian Society of Organ Transplantation in recognition of his role for pioneering transplantation in India.
D Rojas Young Scientist Research Travel Grant, JDRF - $2,000. D Rojas ANZSN Young Investigator Finalist $500.
D Rojas TQEH Research Day 2009. Winner Senior PhD student section. $1,000. S Sen TQEH Research Day 2009. Winner Poster section. $500. S Sen TSANZ Scientific Meeting Awards - Kidney Health Australia Prize for the Best Presentation in the Field of Clinical Research. S Sen TSANZ Scientific Meeting Awards - Young Investigator Award.
R Yu TQEH Research Day 2009. Winner Honours section. $1,000.
Acknowledgements The Renal Unit especially wishes to thank The Queen Elizabeth Hospital Research Foundation for its continuing program, scholarship and small grants support.
We very much appreciate the generous support of the Muriel T Gunn Foundation to enable enhanced work to continue in the Renal Unit.
TQEHresearch Research Report 2009 67 RESPIRATORY MEDICINE UNIT
Research Focus
• Best Practice/medication/counselling combination intervention for inpatient smoking cessation • Positional aspects to obstructive sleep apnoea management • Nitric Oxide • Innovative forms of portable oxygen delivery
“The Respiratory Overview with TQEH Project Officers who have A range of evidence based projects, undergone SA Quit training via collabo- Medicine Unit and pharmaceutical industry new drug trials, rator, John Lit (Flinders Medical Centre). Clinical Practice Unit sleep-related and other studies are The purpose of the project is to evaluate have collaborated underway. the impact of this inpatient initiated new medication/Best Practice counselling, to across multiple In December 2008, a group of TQEH issue smoking cessation as a secondary units at TQEH and Registrars, TQEH Project Officer, and a prevention, in people admitted with TQEH based medical student underwent a smoking related illnesses. beyond to evaluate Cochrane training workshop in Adelaide, the potential run by Vanessa Pitt, of the Melbourne The Pulmonary Function Laboratory is synergistic benefits Cochrane Centre. Using interactive consolidating its formal comparison of lung online methods, the group of Respiratory function in Asian and non Asian subjects to of commencing clinicians/researcher officer/medical student evaluate the need for correction according smoking cessation, learnt how to conduct Cochrane reviews, to ethnicity, and exploring bronchial and now these reviews are well advanced, challenge techniques, including the use for inpatients, under the supervision of Brian Smith, and of Mannitol. using latest anti other members of the Australian Cochrane Airway Group network across most states The Respiratory Research Unit continues to smoking medication of Australia. Several members of this group evaluate a range of new medications for and Best Practice have gone on to participate at advanced COPD, Asthma, IPF and Bronchiectasis lead counselling.” Cochrane courses at the TSANZ ASM in by Drs. Antony Veale and Jon Polasek. Darwin (March 2009) and further Review completion coursework in Melbourne The Respiratory Medicine Unit’s Sleep (November 2009). Laboratory is evaluating the effects of exercise/weight loss/lifestyle upon the The Respiratory Medicine Unit and Clinical indicators of obstructive sleep apnoea, Practice Unit have collaborated across led by Chief Scientist Sean Homan, as well multiple units (Cardiology, Neurology/Acute as looking at diagnosis and therapy of Stroke Service, and Vascular) at TQEH and positional sleep apnoea, led by Dr A. Veale. beyond to evaluate the potential synergistic benefits of commencing smoking cessation, Brian Smith has collaborated with members for inpatients, using latest anti smoking of the British Thoracic Society to produce medication and Best Practice counselling. the 2008 “British Guidelines on the Varenicline, which has PBS approval (unlike Management of Asthma”. nicotine replacement therapy), is superior to nicotine patches at smoking cessation, although has never been formerly evaluated when commenced in an inpatient setting. The South Australian Quit Line which is based on Greenhill Road, provides a year round service to smokers, in the form of highly supportive professionally trained counsellor support, and in combination
TQEHresearch Research Report 2009 68 Staff Grants Director Commonwealth Dept of Health & Aged BJ Smith FRACP Dip Clin Epi PhD Care. Australian Cochrane Airways Group Network ($11,000 2009) Smith BJ et al. Senior Consultants AM Southcott FRACP NHMRC. Effect of asthma during pregnancy R Ruffin MD BSc(Hons) PhD FRACP on placenta and foetus ($216,550 2009) I Nikitins FRACP 2009-2011, Clifton V (Smith BJ A.I.) A Veale PhD FRACP J Polasek FRACP A Roy FRACP Clinical Trials (Dr A M Southcott) Bayer. Bronchitis Study designed to compare Advanced Trainee efficacy of Moxifloxacin® and Amoxycillin® Z Usmani antibiotics in subjects with acute exacerba- M Chandratilleke tions of chronic bronchitis ($1,897 2009).
Principal Medical Scientist Boehringer Ingelheim. Asthma study S Homan MSc designed to assess the efficacy of Spiriva® as add-on controller therapy on top of usual Pulmonary Function Laboratory medication for subjects with severe asthma D Keatley BSc(Biomed)(Hons) ($28,270 2009). A Herrero Adv RSC Cert of Science N Leonardis BSc Boehringer Ingelheim. LABA Emphysema study designed to assess efficacy of a new Clinical Trials Unit Coordinator long acting medication for subjects with K Boath Mgt Cert Adv Cert BHlthSc emphysema ($69,883 2009).
Research Nurse Boehringer Ingelheim. Idiopathic Pulmonary P Gluyas RN RM CC Cert Fibrosis study designed to evaluate efficacy of a new medication to prevent scarring of Sleep Laboratory lungs and disease progression in subjects M Smith BSc with Idiopathic Pulmonary Fibrosis ($57,288 T Faulkner BPsych(Hons) 2009). T Hams (Admin) Sanofi. Insomnia study designed to assess Respiratory Nurses efficacy of a new sleep medication for L Kotal RN RM CC Cert Post Grad Dip Health subjects with sleep maintenance insomnia ($13,257 2009). Counselling K Lawton BAN
Unit Pharmacist T Jones B Pharm Dip Ed PhD
Secretarial H Gummow V Daly M Ashley
PhD Student J Bignall “Positional effects of obstructive sleep apnoea” Supervisors: B Smith, A Veale
TQEHresearch Research Report 2009 69 RHEUMATOLOGY UNIT Research Focus • Autoimmunity • Osteoarthritis • Epidemiology • Giant Cell Arteritis • Immunogenetics Dr Maureen Rischmueller
“Genetic variation Overview Dr Maureen Rischmueller’s research in the P2X7 The Department of Rheumatology strives to group, led by Medical Scientist Ms Sue augment its clinical rheumatology services Lester, continues to focus on the genetics receptor is with research programs into the causation of autoimmunity, providing insights into providing and complications of rheumatic diseases biological mechanisms underlying disease, important clues and evaluation of new generations of and ultimately enabling identification of pharmaceutical agents for the treatment of therapeutic targets. In addition to their large into the arthritis. The major focus of this research is cohort of patients with Sjögren’s syndrome, pathogenesis towards the immunogenetics, pathogen- they, in collaboration with Drs Simon esis, and epidemiology and treatment of a Burnet, Catherine Hill, and Samuel Whittle, of Sjögren’s number of rheumatic diseases. are continuing to archive DNA and serum syndrome.” samples from a range of other rheumatic Two important developments have diseases, such as systemic lupus erythema- occurred within the past year. The first is tosus, scleroderma osteoarthritis and giant the opening of the new research facility cell arteritis. Further, they are archiving DNA at The queen Elizabeth Hospital (TQEH) from the NWAHS cohort, an important which has enabled the relocation of the resource for research at TQEH. Their collabo- Rheumatology Research Laboratory from ration with Professor James Wiley, Nepean the Hanson Institute to TQEH. The second Hospital, Sydney, pertaining to the P2X7 is the involvement of the Rheumatology receptor in Sjögren’s syndrome is on-going. Department in both the Centre for Inflam- Genetic variation in the receptor is providing matory Diseases Research and the Health important clues to the pathogenesis of Observatory program grants funded by Sjögren’s syndrome, and further Dr Bac Hai TQEH Research Foundation. These develop- Tran has identified, and mapped the epitope, ments have enabled the consolidation of a novel P2X7 autoantibody which has of Rheumatology research in addition to great potential to be both disease specific strategic collaborations with opportunities (and therefore be of use in a diagnostic for the integration of our clinical, scientific capacity) and functionally important in the and epidemiological research interests. dryness, and other autonomic, symptoms associated with this disease. Associate Professor Catherine Hill is chief investigator on an NHMRC funded randomized clinical trial of fish oil in the treatment of knee osteoarthritis and is a chief investigator on the Health Observa- tory Program grant funded by The Queen Elizabeth Hospital research Foundation. Her other current areas of investigation include population studies of musculoskel- etal disorders, including data from the North West Adelaide Health Study (NWAHS) cohort study, influence of health literacy on health outcomes and chronic diseases, investigation of the association of malignancy and giant cell arteritis (GCA), establishment of SA GCA Registry, system- atic reviews of steroid sparing agents in GCA and PMR.
TQEHresearch Research Report 2009 70 Staff New grants awarded for 2010 Director/Senior Lecturer Arthritis Australia. (Project grant) Association M Rischmueller MBBS FRACP of n-3 fatty acid levels and serum COMP levels with inflammation, symptoms and cartilage Staff Specialists volume in knee osteoarthritis. ($35,000 2010) S Burnet MBBS FRACP Hill CL, Cleland LG, Jones G, March LM. CL Hill MBBS MD MSc(Epi) FRACP SL Whittle MBBS FRACP Arthritis Australia. (Project grant) Novel autoantibodies target purinergic receptors in Registrar patients with Sjogren’s syndrome. ($15,000 M Wechalekar MBBS 2010) Tran H, Neufing P, Rischmueller M. V Katikireddi MBChB(Hons) MRCP(UK) TQEH Research Foundation. (Small grant) Is Medical Scientists XIAP a susceptibility gene for asthma? ($5,000 S Lester BSc(Hons) 2010) Zalewski P, Roscioli E, Lester S. H Tran BSc PhD
Technical Officer J McLean
Clinical Trials Coordinators S Downie-Doyle BSc(Hons) PhD R Battersby BSc Grad Cert Drug Development
Clinical Trials Assistant/Administrative Support J Marrett BBus(Mkt) M Bubicich BSc(Hons) M Devine
Rheumatology Clinical Nurses A Batty BNursing C Tosh Dip AppSc(Nursing)
Grants NHMRC Project Grant (ID# 451900). Fish Oil in knee osteoarthritis ($162,875 2009) 2008-2010, Hill CL, Cleland LG, Jones G, March LM.
TQEH Research Foundation Strategic Initia- tives Funding Program Grant. The Health Observatory ($250,000 2009) 2009-2013, Adams RJ, Wilson DW, Hill CL, Visvanathan R, Ruffin RE, Wittert G.
TQEH Research Foundation Strategic Initia- tives Funding Program Grant. Inflamma- tory mechanisms and therapies in chronic disease - asthma, COPD, stroke, cerebrov- ascular disease, rheumatology diseases and chronic rhinosinusitis ($175,000 2009) 2009-2011. Wormald PJ, Koblar SA, Lang CJ, Lester S, Rischmueller M, Tan LW, Zalewski P.
TQEHresearch Research Report 2009 71 SURGERY, University of Adelaide Discipline of Research Focus • Liver tumour ablation • Fast track colorectal cancer surgery • Abdominal adhesion prevention • Single port surgery • Vascular disease risk factors • Increase use of local anaesthesia for day surgery
• Sinus surgery and its pathophysiology Professor Guy Maddern
“The University of Overview Institute and saw over forty two papers Adelaide Discipline The University of Adelaide Discipline of presented by young surgical researchers in Surgery this year has again provided a large November 2009. of Surgery has also range of research endeavours and publica- become a central tions. Over sixty papers have been produced The pressure of delivering high quality in areas as diverse as surgical history, upper research with the almost insatiable demand hub for stimulating gastrointestinal cancer surgery, ear nose and for surgical service delivery is a difficult one; surgical research throat surgery, vascular surgery, colorectal however the Discipline seems to be reaching a sustainable balance. around the country.“ surgery and plastic surgery. The nature of the research output from the Discipline has been broad-based with Staff a large number of clinical reports, some RP Jepson Professor of Surgery important laboratory and benchtop work Head, Discipline of Surgery and a considerable amount of research Head, School of Medicine involving animal experimentation. The Director, Division of Surgery outcomes to date have led to a number of Director of Research, Basil Hetzel research grant successes, in particular the Research Institute awarding by NHMRC of over $1 million to GJ Maddern MBBS PhD MS MD FRACS Associate Professor Rob Fitridge for his work on aortic aneurysm risk factors and develop- Associate Professors ment of a predictive model to enable more R Fitridge MBBS MS FRACS timely management of them. N Rieger MBBS MS FRACS WEW Roediger MBBCh MSc DPhil(Oxon) FRACS Professor PJ Wormald has also been successful in obtaining ongoing support Senior Lecturers from the Garnett Passe & Rodney Williams M Bruening MBBS MS FRACS Memorial Foundation and with his M Goggin MBBCh BAO FRCSI(Ophth) FRCOphth DO Chief Scientist, Dr Lor Wai Tan, has been J Miller MBBS FRACS successful in supervising a large number of G Rees MBBS FRACS higher degree students during their surgical D Rodda MBBS FRACS training. The work of Professor Wormald D Walsh MBBS FRACS has been linked with Professor Maddern in attempting to develop the utility of novel Staff Specialists treatments for the assessment of intra- A Anthony MBBS FRACS abdominal adhesions which, if successful, C Barry MBBS, MRCOG, FRANZCOG would have an enormous impact on the N Giles BMBS, FRACP cost and morbidity of surgical care. M Hamilton MBCHB, FRACS P Hewett MBBS FRACS The University of Adelaide Discipline of H Kanhere MBBS, FRACS Surgery has also become a central hub C Lai MBBS FRACS for stimulating surgical research around A Singla MBBS, FRANZCOG the country and for the second year has D Tonkin MBBS, FRACS hosted the Surgical Research Society annual D Walters MBBS FRACS meeting at the Basil Hetzel Institute. This N Wright MBBCH, FRSA is likely to become an annual event at the P Subramaniam MBBS FRACS
TQEHresearch Research Report 2009 72 Clinical Title Holders B McCusker Clinical Lecturer “The pressure of S Ali Clinical Lecturer R McGovern Clinical Lecturer A Anthony Clinical Lecturer K Moretti Clinical Lecturer delivering high W Babidge Affiliate Lecturer J Muecke Clinical Lecturer quality research F Bridgewater Clinical Assoc/Professor S Neuhaus Clinical Assoc/Professor with the almost P Byrne Clinical Lecturer R Parkyn Clinical Assoc/Professor B Carney Clinical Lecturer M Patkin Clinical Lecturer insatiable demand D Close Clinical Lecturer C Pozza Clinical Lecturer for surgical service P Cowled Affiliate Senior Lecturer T Proudman Clinical Senior Lecturer A Cowin Affiliate Associate Professor M Rao Clinical Assoc/Professor delivery is a difficult P Drew Visiting Research Fellow S Raptis Clinical Senior Lecturer one; however the A Economos Clinical Lecturer T Rayner Affiliate Lecturer P Fleming Clinical Lecturer D Roach Clinical Senior Lecturer Discipline seems H Forbes Clinical Lecturer C Russell Clinical Associate Lecturer to be reaching N Gehling Clinical Lecturer S Sabaratnam Clinical Lecturer a sustainable P Hewett Clinical Professor N Sacks Clinical Professor V Humeniuk Clinical Lecturer R Strickland Clinical Lecturer balance.” A Karagiannis Clinical Lecturer P Stuart Clinical Lecturer A Karatassas Clinical Lecturer P Sutherland Clinical Senior Lecturer C Lai Clinical Senior Lecturer LW Tan Affiliate Senior Lecturer M Lloyd Clinical Lecturer M Tie Clinical Lecturer A Luck Clinical Senior Lecturer RP Jepson Research Fellow E Mah Clinical Senior Lecturer P Cowled PhD
Postgraduate Students PhD candidates S Krishnan BHlthSc(Hons) “The clinical evaluation of fast-track surgery including extended local anaesthetic infusion for post-operative pain”
N Ruzehaji BSc(Hons) “The role of Flii in the pathology of diabetic wounds” BAppSc(Podiatry)
J Smith PhD “The litigation threat to surgical practice: Legal reform and risk management”
Honours candidates D Dawson “Pathophysiology of small bowel damage following hind limb ischaemia reperfusion injury” J Smale “Bimodal electric tissue ablation (BETA) as an adjunct to liver resection”
Master of Surgery P Ho MBBS “Physician Assistants: Trialling a new health professional in the South Australian health System
C Lauder MBChB MRCS “Peritoneal adhesion formation and modulation”
TQEHresearch Research Report 2009 73 Technical Officers Department of Health, Western Australia. B Hutchens WA Audit of Surgical Mortality ASERNIP-S. M Slawinski ($303,000 2008-2009) 2008–2010, M Smith Maddern GJ.
Research Assistants National Breast Cancer Centre. National S Lane BA(Mgt)(Hons) Breast Cancer audit ASERNIP-S. ($240,000 L Leopardi BSc BEng(Biomedical)(Hons) 2008-2009) 2006–2009, Maddern GJ. S Page BMedSc(Hons) NHMRC Development of novel treatment Clinical Trials Coordinators for wounds. ($62,500 2009) 2008–2010, C Chian BSc(Hons) LLB GDLP Cowin A. B Sivendra BMedRad(NucMed) NHMRC Project Grant. Prospective evalua- Colorectal Research Coordinators tion of a model to predict outcomes S Singh BPharm MPharm following endovascular aortic aneurysm J Stephens BSc(Hons) MPH repair. ($253,950 2009) 2009–2013, Fitridge R, Boult M, Golledge J, Maddern GJ, Vacation Scholarships 2009-10 Thompson M, Barnes M. W Pan Royal Australasian College of Surgeons Foundation for Surgery. Louis Waller Grants Medico-Legal Scholarship. ($60,000 2009) Australian Research Council. Managing and Smith J. mining evolving ontologies through pattern languages and data mining. ASERNIP-S Royal Australasian College of Surgeons/ in collaboration with Flinders University MMM/CCANZ. Colorectal Cancer Audit and Australian Computer Society ASERNIP-S. ($69,388 2008–2009) (SA Branch) ($49,300 2009) 2006–2009, Maddern GJ. Maddern GJ. Royal Australasian College of Surgeons/ Commonwealth Department of Health and MMM/CCANZ. Colorectal Cancer Audit Aged Care. Horizon Scanning ASERNIP-S. ASERNIP-S. ($115,000 2008–2009) ($130,000 2009) 2006–2009, Maddern GJ. Maddern GJ.
Commonwealth Department of Health and South Australian Department of Health. Aged Care. Systematic reviews ASERNIP-S. ENT Funding. ($454,000 2008–2009) (198,000 2008–2009) Maddern GJ. Maddern GJ.
Commonwealth Department of Health South Australian Department of Health. and Aged Care. Simulated Surgical South Australian Audit of surgical mortality Skills Program ASERNIP-S. ($5,000,000 ASERNIP-S. ($170,000 2008-2009) 2008–2011) Maddern GJ. 2006–2009, Maddern GJ.
Department of Health Queensland. Queens- TQEH Research Foundation Strategic Initia- land Audit of Surgical Mortality ASERNIP-S. tives Funding. (Program grant) Vascular ($333,000 2009) 2006–2009, Maddern GJ. Diseases and Therapeutics Research. ($180,000 2009) 2009–2011, Horowitz JD, Department of Health, Tasmania. Tasmanian Beltrame J, Zeitz C, Wilson DP, Morris RJ, audit of surgical Mortality ASERNIP-S. Sallustio B, Chirkov Y, Kennedy J, Cowled PA. ($29,000) 2007–2009 ($165,000 2008-2009) 2008–2011, Maddern GJ. TQEH Research Foundation Strategic Initia- tives Funding. (Program grant) Develop- Department of Health Victoria. Victorian ment and Assessment of novel surgical Audit of Surgical Mortality ASERNIP-S. technologies and their introduction into the ($48,895 2008-2009) 2007–2009, Australian healthcare system. ($250,000 Maddern GJ. 2009) 2009–2013, Maddern G, Wormald PJ, Jamieson G, Fitridge R, Hewett P.
TQEHresearch Research Report 2009 74 TQEH Research Foundation. (Small grant Spinal Fellow “TQEH 2009) Breast cancer in the elderly client S Zahari MBBS Malaya, MMed (Ortho) – determining the evidence to improve Orthopaedics and treatment outcomes. ($16,000 2009) Hand and Upper Limb Fellow Trauma currently Walsh D, Redman K. T Sharpe MB CHB Glasgow FRACS performs the TQEH Research Foundation. (Small grant Project Officer (CNAHS) second largest 2009) Breast cancer follow up at The Queen M Sutton B Physio number of primary Elizabeth Hospital – developing future models of care. ($14,000 2009) Walsh D, Arthroplasty Outcomes Officer arthroplasty Redman K. G West B Physio procedures of
TQEH Research Foundation/University of Research Officer the public Adelaide. Postgraduate Divisional Research T Mayo B Psych(Hon) hospital units in Scholarship ($20,427 2009) Ho P. South Australia.” Executive Secretary TQEH Research Foundation. Honours B Stoddard Research Scholarship ($4,000 2009) Smale J. Secretaries E Smythe L Georgeff J Whatling ORTHOPAEDICS AND TRAUMA, TQEH Department Nursing Staff L Thomas CNC – Joint Replacement Staff J Gould CNM – Joint Replacement Director C Butcher MBBS FRACS FAOrthA (to Oct 09) Orthopaedics and Trauma G Morrison MBChB FRCS (Ed) FRACS FAOrthA current research activities (from Nov 09) TQEH Orthopaedics and Trauma currently performs the second largest number of Deputy Director primary arthroplasty procedures of the G Morrison MBChB FRCS (Ed) FRACS FAOrthA public hospital units in South Australia. (to Oct 09) In the future TQEH will consolidate its N Cullen MD FRCS(C) FRACS FAOrthA position as a major centre for conducting (from Nov 09) clinically based research for the monitoring of prosthetic implants. The TQEH uses Senior Lecturer internationally recognised outcome A Fagan MBBS (Adel) FRCS (Glas) measures for the purposes of Quality Assurance and as an approach to evidence Visiting Specialists based decision making. ET Mah MD BMBS FRACS FAOrthA P Lewis MBBS FRACS FAOrthA The Unit has expanded its base research O Osti MD PhD FRACS FAOrthA infrastructure to allow for the implemen- L Ferris MBBS BSc(Med) FRACS tation of consultant driven research trials R Montgomery MBBS FRACS deemed to be of significant interest to J van Essen MBBS FRACS(Ortho) the orthopaedic as well as the wider W. Duncan MBBS FRACS(Orth) community. As one of the Orthopaedic G Nimon MBBS FRACS(Orth) teaching hospitals, this facility also gives C Begg MBBS FRACS(Orth) the opportunity for Orthopaedic Fellows, T Stevenson MBChB FRCS FRACS FAOrthA Trainees, Senior Registrars and orthopaedic N Pourgeizis MBBS FRACS(Orth) junior medical staff to participate in C Gooi MBBS FRACS(Orth) research culminating in the potential for presentations and publications necessary Arthroplasty Fellow for their career progress. A Hopcroft (Trauma & Orth)
TQEHresearch Research Report 2009 75 “The Unit has Trials completed New Trials Lewis P, Butcher C, West G, Deo H, Rickman Morrison G, Cullen N, Duncan W, Begg C, expanded its M, Chatterji U, Prakash U, Gillespie P, Mount van Essen J, Lewis P, Montgomery R. Total base research P, Ludbrook G. Cognitive Function following Knee Arthroplasty Using Patient Specific infrastructure Total Joint Arthroplasty – is there a problem? Templating – An Outcome Study. to allow for the Recruitment complete Funding for research in this department has implementation of – Follow up continues been obtained totally from industry contri- Bauze R, Clayer M, Lewis P, Stevenson T, butions to the Orthopaedic and Trauma consultant driven Morrison G, Butcher C, Waters D, Mah Research Fund. In 2009 contributions have research trials E, Brook P, Cullen N. A Comparative Trial come from Stryker ($41,800) and Biomet between the Spectron Total Hip Replacement ($14,850). deemed to be of and the Exeter Total Hip Replacement. significant interest to the orthopaedic Munyard A, Cullen N. A Trial of the TRAC Mobile Bearing Total Knee Replacement. as well as the wider Butcher C, Lewis P, Stevenson T, Morrison G, community.” Waters D, Mah E, Brook P, Bauze R, Clayer M. A Comparative Trial between the NexGen Fixed Bearing Total Knee Replacement and the NexGen Rotating Platform Total Knee Replacement.
Recruitment continues Butcher C, Lewis P, Phillips S, Duncan W, Morrison G, van Essen J, Cullen N, West G. Functional and Perceived Outcome Study Comparing Posterior Cruciate Substituting and Cruciate Retaining Inserts in a Multi-axis Radius Knee.
Lewis P, Butcher C, Phillips S, West G. Functional Outcome Study Comparing Single and Multi-axis Femoral Component Designs of Knee Replacements.
Lewis P, Butcher C, Phillips S, Gillespie, P, Morrison G, Cullen N, Duncan W, West G Functional Outcome Study Comparing Small and Large Diameter Metal on Metal Hip Prostheses.
Deshaies A, Lewis P, Butcher C, Gillespie P. Evaluation of Blood Flow in the Proximal Tibia during Unicompartmental and Total Knee Replacements.
Mah E, Sharma K. Comparative study on the clinical outcome of arthrodesis versus arthro- plasty for small finger carpo-metacarpal arthritis – a prospective randomized study.
Ferris L, Cullen N, Wilkinson D, Fintland J. Functional Outcome Study Treating Tendinopathy in and around the foot using Hyperbaric Oxygen (HBO) treatment.
TQEHresearch Research Report 2009 76 THERAPEUTICS RESEARCH CENTRE, University of South Australia Research Focus The general theme of our research at the Therapeutics Research Centre, is the investigation of pharmacological strategies that may improve quality of life and other patient outcomes.
Our work has been at all levels of therapeutic research, namely: drug design, drug delivery, pharmacokinetics, toxicology and quality use of medicines and natural products for a range of diseases and for patients in institutions and at home.
Overview • Enhancement of drug & cosmeceuti- “The Topical Drug The Director of this Unit, Professor Michael cals delivery using physical techniques Roberts, is an Australian National Health & (iontophoresis, sonophoresis, abrasion) Delivery Group’s Medical Research Council Senior Principal • Physiological factors affecting drug & interests range from Research Fellow based at both The Institute cosmeceuticals distribution in the skin practical aspects of (Basil Hetzel Institute) (affiliated with the • Effect of blood flow on drug & UniSA School of Pharmacy) and the School cosmeceuticals clearance from the skin drug delivery of Medicine at Princess Alexandra Hospital and tissue distribution system design in Brisbane, Australia. His research interests • Prediction and modeling of drug & are in experimental and clinical therapeu- cosmeceuticals skin penetration kinetics through to tics and in pharmaceutical science. Staff • Effect of various skin diseases on drug & theoretical began working at the BHI in August 2009 cosmeceutical absorption investigation and in collaboration with the research groups based in Brisbane and UniSA City East Liver mathematical campus and the group will grow signifi- Current areas of liver research include the: modelling of cantly in the year ahead. • Effects of various liver diseases (e.g cirrhosis, non-alcoholic fatty penetration and Skin liver disease) on drug hepatic distribution of The Topical Drug Delivery Group’s interests pharmacokinetics range from practical aspects of drug delivery • Relationship between the severity of solutes within system design through to theoretical the liver disease and drug levels in liver various skin layers.” investigation and mathematical modelling transplant patients of penetration and distribution of solutes • Effects of repeat dosing of a within various skin layers. Publications vasoactive drug on its own hepatic arising from our work have dealt with the pharmacokinetics relationships between physical or chemical • Effects of cardiovascular diseases properties of topically applied drugs and (e.g. heart failure, primary hypertension, their distribution within the skin, as well as atherosclerosis) on drug disposition in the effect of various skin pre-treatments on the liver subsequent drug permeation. The group • Pharmacokinetics of sulphonylureas and has also published invited reviews on factors several antibiotics in the pancreas influencing the formation of drug reservoirs within the skin following topical applica- Clinical Analyses tion and the latest developments in physical The research interests of the Drug Analysis forms of topical drug delivery, such as jet and Medicinal Chemistry Group include: injectors and electrically-enhanced permea- • Clinical sample analysis by HPLC & LCMS. tion technologies. Assay development for drugs and small molecules in biological fluids Areas of research include: • Synthesis of novel drugs and drug deriva- • Effect of drug & cosmeceutical structure tives for assessment in ADMET studies. on skin permeability kinetics • Effect of vehicle/formulation on skin Clinical Imaging and Modelling Group absorption The Imaging and Modelling Group focuses • Targeting of drugs & cosmeceuticals into on the contribution that the physical and hair follicles mathematical sciences can make to our
TQEHresearch Research Report 2009 77 research. This includes the development “However, it also of pharmacokinetic models to describe incorporates the transdermal permeation, using traditional use of cutting- statistical methods (in conjunction with the Topical Drug Delivery Group). However, it edge methods also incorporates the use of cutting-edge and technologies methods and technologies to improve our understanding of transdermal permeation, to improve our including molecular simulation and fluores- understanding cence microscopy.
of transdermal Research interests include: permeation, • Pharmacological modelling of including molecular transdermal permeation processes; • Molecular modelling of transport simulation and processes in the stratum corneum; fluorescence • Application of microscopy to transdermal penetration studies; and microscopy.” • Application of microscopy in skin pathology assessment.
Staff UniSA Research Chair: Therapeutics & Pharmaceutical Science MS Roberts BPharm PhD DSc
UniSA Research Fellow TA Robertson BSc PhD
Grants NHMRC. (Project grant # 569710) Pharmacodynamics in Liver Disease and in Liver Surgery. ($288,592 2009) 2009-2011, Roberts MS.
The Queen Elizabeth Hospital Research Foundation. (Small grant 2009) An investigation of pharmacokinetic- pharmacodynamic characteristics of various beta-lactam antibiotics in patients with sepsis using microdialysis ($4,000 2009) Peake S, Robertson T, Lipman J, Roberts J, Roberts M.
TQEHresearch Research Report 2009 78 TQEHresearch Research Report 2009 79 Publications
TQEHresearch Research Report 2009 80 Publications
ANAESTHESIA, Kennedy JA, Hua X, Mishra K, Murphy Wiley-Blackwell, West Sussex, UK. GA, Rosenkranz AC, Horowitz Chapter 18, Pg 167-77, 2010. Department of JD. Inhibition of calcifying nodule Papers formation in cultured porcine aortic Abstracts Kadam VR, Moyes D, Moran JL. valve cells by nitric oxide donors. Kennedy JA, Murphy GA, Mishra K, Relative efficiency of two warming Eur J Pharmacol. 2009; 602:28-35. Horowitz JD, Inhibition of TGF-beta1 devices during laparoscopic cholecys- induced calcifying nodule formation tectomy. Anaesthesia & Intensive Care. Maseri A, Beltrame JF, Shimokawa H. by prostanoid receptor stimulation in 2009; 37(3):464-8. Role of Coronary Vasoconstriction in porcine aortic valve interstitial cells. Ischemic Heart Disease and the Search European Journal of Heart Failure for Novel Therapeutic Targets. Circ J. Suppl. 2009; 8(2):1273. CARDIOLOGY UNIT 2009; 73(4):394-403. Papers S. Kanagasingam N, Horowitz JD, Ball CJ, Wilson DP, Turner SP, Saint DA, Ngo DT, Sverdlov AL, McNeil JJ, Kennedy JA. Development of aortic Beltrame JF. Heterogeneity of Horowitz JD. Correlates of arterial valve cellular calcification is associ- L- and T-Channels in the Vasculature: stiffness in an ageing population: ated with intracellular redox stress: A Rationale for the Efficacy of role of asymmetric dimethylarginine. amelioration by nitric oxide. European Combined L- and T-Channel Blockade. Pharmacol Re. 2009; 60(6):503-7. Journal of Heart Failure Suppl. 2009; Hypertension. 2009; 53(4):654-60. 8(2):1596. Ngo DT, Sverdlov AL, Willoughby SR, Beltrame JF, Crea F, Camici P. Advances Nightingale AK, Chirkov YY, McNeil S. Kanagasingam N, Horowitz JD, in Coronary Microvascular Disease. JJ, Horowitz JD. Determinants of Kennedy JA. Transforming growth Heart Lung Circ. 2009; 18(1):19-27. occurrence of aortic sclerosis in an factor-β1 increases thioredoxin- aging population. JACC Cardiovasc interacting protein in calcifying aortic Beltrame JF, Ganz P. Evaluating patients Imaging. 2009; 2(8):919-27. valve cells: attenuation by nitric oxide. with persistent chest pain and no Heart Lung and Circulation. 2009; obstructive coronary artery disease. Rajendran S, Willoughby SR, Chan 18S:S193. JAMA. 2009; 302(6):622-3. WPA, Liberts EA, Heresztyn T, Saha M, Marber MS, Norman RJ, Horowitz JD. Beltrame JF, Horowitz JD. The 56th Polycystic Ovary Syndrome is Associ- CLINICAL Cardiac Society of ANZ Annual ated with Severe Platelet and Endothe- Scientific Meeting: Focused Symposia lial Dysfunction in Both Obese and PHARMACOLOGY UNIT on Public Health. Heart Lung Circ. Lean Subjects. Atherosclerosis. 2009; Papers 2009; 18(2):93. 204(2):509-14. Martin JH, Morris RG, Beer C. What changes are needed to the current Beltrame JF, Horowitz JD. The 56th Ritchie RH, Irvine JC, Rosenkranz direction and interpretation of clinical Cardiac Society of ANZ Annual AC, Patel R, Wendt IR, Horowitz cancer research to meet the needs of Scientific Meeting: Focused Symposia JD, Kemp-Harper BK. Exploiting the 21st century? Med J Aust 2009; on Basic and Clinical Science. Heart cGMP-based therapies for the preven- 190:74-77. Lung Circ. 2009; 18(1):2. tion of left ventricular hypertrophy: NO* and beyond. 2009. Pharmacol Wallemacq P, Armstrong VW, Brunet Beltrame JF, Weekes AJ, Morgan C, Ther. 2009; 124(3):279-300. M, Haufroid V, Holt DW, Johnston Tavella R, Spertus JA. Prevalence of A, Kuypers D, Le Meur Y, Marquet Weekly Angina Among Patients with Wilson DP, Ball CJ, Turner SP, Saint DA, P, Oellerich M, Thervet E, Toenshoff Chronic Stable Angina in Primary Care Beltrame JF. Response to Combined B, Undre N, Weber LT, Westley Practices. The Coronary Artery Disease in L-and T-Channel Blockade is Better IS, Mourad M. Opportunities to General Practice (CADENCE) Study. Arch than L-Channel Blockade Therapy. optimize tacrolimus therapy in solid Intern Med. 2009; 169(16):1491-99. Hypertension. 2009; 54(1):e3-4. organ transplantation: report of the European consensus conference. Ther Keech A, Horowitz JD. Cost-effective- Book Chapters Drug Monit. 2009 Apr;31(2):139-52. ness considerations of cardiovascular Kucia AM, Beltrame JF. Presentations therapeutics. Heart Lung Circ. 2009; of Acute Coronary Syndromes. In AM Abstracts 18(2):118-22. Kucia and T Quinn (ed) Acute Cardiac Krishnan S, Morris RG, Hewett P, Care – A Practical Guide for Nurses. Karatassas A, Tonkin J, Field J. Local
TQEHresearch Research Report 2009 81 anaesthetic infused at the incision Proceedings 2009 Sept; 14:P2-68. Close A, Phillips PJ. Lifestyle and site for post-operative pain manage- Norris RL, Morris RG, Ray JE, Fullinfaw diabetes care. Conquest. Spring 2009 ment following abdominal surgery: An RO Ilett KF, Lee T, Martin J, Barras M, (September-November) 22–23. interim analysis. [Proc 29th Aust Pain Thompson EM, Jones GRD. Preliminary Soc Mtg.] 2009; 100. results of a therapeutic drug monitoring Cole A, Gill T, Shanahan EM, Phillips P, survey in Australasia. Pathology. 2009; Taylor A, Hill CL. Is diabetes associated Krishnan S, Morris RG, Hewett P, 41(Suppl):71. with shoulder pain or stiffness: Results Karatassas A, Tonkin J, Field J. Local from a population-based cohort study. anaesthetic infused at the incision Norris R, Morris RG, Thompson E, J Rheumatol. 2009; 36:371-7. site for post-operative pain manage- Ray JE, Baras M, Jones G, Martin J. A ment following abdominal surgery: An Survey of therapeutic drug monitoring Dal Grande E, Gill TK, Wyatt L, Chittle- interim analysis. Basic Clin Pharmacol in Australasia. Ther Drug Monit. 2009; borough CR, Phillips, PJ, Taylor AW. Toxicol. 2009; 105(S1):61. 31(5):664. Population attributable risk (PAR) of overweight and obesity on chronic Krishnan S, Morris RG, Hewett P, Sallustio BC, Westley IS, Coller JK, Ward diseases: South Australian representa- Karatassas A, Tonkin J. Does the MB, Russ GR, Morris RG. Frequency of tive, cross – sectional data, 2004 – infusion of local anaesthetic at the genetic polymorphisms in the promoter 2006. Obes Res Clin Prac. 2009 Aug; incision site provide adequate pain (C-24T), exon 10 (G1249A) region of 3(3):159-168. relief following abdominal surgery? ABCC2 in Australian renal transplant An interim Analysis. Ther Drug Monit. recipients and donors. Ther Drug Giles J, Visentin K, Phillips PJ. Diabetes 2009; 31(5):663. Monit. 2009; 31(5):656-7. in Aged Care. Australian Nursing Journal. 2009 Feb;16(7):40. Krishnan S, Morris RG, Hewett P, Sallustio BC, Morris RG. Total bilirubin Karatassas A, Tonkin J, Field J. Local concentration in plasma of renal Grant JF, Hicks N, Taylor AW, Chittle- anaesthetic infused at the incision transplant patients may reflect differ- borough CR, Phillips PJ; The North site for post-operative pain manage- ences in MRP2 inhibition by cyclosporine West Adelaide Health Study Team. ment following abdominal surgery: An and tacrolimus. Drug Metabolism Gender-specific epidemiology of interim analysis. TQEH Research Day, Reviews. 2009; 41(Sup. 3):77. diabetes: a representative cross- Oct 2009. sectional study. Int J Equity Health. Sallustio BC. Pharmacogenetics of Renal 2009 Mar 11:8(1):6. Krishnan S, Morris RG, Hewett P, Transplantation ASCEPT Proceedings. Karatassas A, Tonkin J, Field J. Local 2009 Sept; 14:O86. Phillips PJ. Antiplatelet therapy, Helico- anaesthetic infused at the incision bacter pylori infection and compli- site for post-operative pain manage- Westley IS, Di Fazio V, Vanbinst R, cated peptic ulcer disease in diabetes: ment following abdominal surgery: An Wallemacq P. HPLC-MS/MS assay for The Fremantle Diabetes Study. 2009 interim analysis. ASCEPT Proceedings. the determination of Imatinib and its Diabetes UK, Diabetes Medicine. 26, 2009 Sept; 14:P1-22. metabolites CGP74588 concentrations 70-75. in plasma. Ther Drug Monit. 2009; Licari J, Somogyi AA, Pierides J, 31(5):643. Phillips PJ. A1c and CVD – how low to Sallustio BC. Comparison of Sprague go? Medicine Today. December 2009; Dawley and Dark Agouti rats as animal Book Chapters Vol 10, Number 12:55-56. models of perhexiline-induced hepato- Upton RN, Myburgh JA, Morris RG. toxicity. Drug Metabolism Reviews. Pharmacokinetics, pharmacodynamics Phillips PJ, Evans A. The ABCS of foot 2009; 41(Sup. 3):128. and drug monitoring in critical illness. care in diabetes: S is for structure. In: Oh’s Intensive Care Manual 6th Medicine Today. May 2009; Vol10, MD Dom Z, Sallustio BC, Somogyi edition. (Bersten A.D, Soni N. eds). Number 5: 59-66. AA. Metabolism of mycophenolic acid London: Butterworth Heinemann in human liver microsomes: effect Elsevier. 2009; pp. 897-912. Phillips PJ. The insulin KISS in older of tacrolimus, cyclosporine and its people with type 2 diabetes. (‘Keep metabolites. ASCEPT Proceedings. insulin safe and simple’). Medicine 2009 Sept; 14:P2-64. Today. January 2009; Vol10, Number ENDOCRINOLOGY UNIT 1: 27–34. Papers Morris RG. Are therapeutic drug assays Chittleborough CR, Burke MJ, Taylor AW, misleading clinical staff? Can we do Phillips PJ, Evans A. The ABCS of Wilson DH, Phillips PJ, Adams RJ, Ruffin it better? ASCEPT Proceedings. 2009 foot care in diabetes: C is for care. RE; North West Adelaide Health Study Sept; P-11. Medicine Today. March 2009; Vol 10, Team. Medicare-related service use and Number 3:79–82. costs among people with diagnosed Noll BD, Coller JK, Somogyi AA, Morris and undiagnosed diabetes and respira- RG, Sallustio BC. Measurement of Phillips J, Phillips PJ. Children get type tory conditions. Aust Health Rev. 2009 cyclosporine in kidney transplant 2 diabetes too. Australian Family Feb;33(1):107-16. biopsies using HPLC-MS/MS. ASCEPT TQEHresearch Research Report 2009 82 Physician. September 2009; Vol 38, No Roberts-Thomson IC, Teo E, Maddern Safety and sensitivity of two ultrasound 9, 699 -703. GJ. Bile duct injuries associated with strategies in patients with clinically cholecystectomy. Journal of Gastro- suspected deep venous thrombosis; Phillips PJ, Burnet S. Cally’s carpal enterology and Hepatology. 2009; a prospective management study. complaint. Australian Family Physician. 24:706-708. J Thromb Haemost. 2009 March 2009; Vol 38, No 3. Dec;7(12):2035-41. Roberts-Thomson IC, Teo E. Colonos- Phillips PJ. Diabetes in Australia – our copy: Art or science? Journal of Gastro- Hutton JF, Gargett T, Sadlon TJ, Bresatz 2009 report card. Conquest. Summer enterology and Hepatology. 2009; S, Brown CY, Zola H, Shannon MF, 2009; (December-February) 10–11. 24:180-184. D’Andrea RJ, Barry SC. Development of CD4+CD25+FoxP3+ regulatory T cells Phillips PJ. The Insulin KISS. Conquest. Tooley KL, Cummins AG, Grose RH, Lymn from cord blood hematopoietic progen- Spring 2009; (September – November), KA, El-Merhibi A, DeNichilo M, Penttila itor cells. Journal of Leukocyte. Biology 10–11. IA. Maternal milk but not formula milk 2009; 85:445-451. regulates the immune response to Phillips PJ. Diabetes and the Geriatric introduction of food antigens. Journal Powell JA, Thomas D, Barry EF, Kok CH, Giants. Geriatric Medicine in General. Nutrition. 2009; 139:2145-2151. McClure BJ, Tsykin A, To LB, Brown A, Practice Volume 3, October 2009, 8-10. Lewis ID, Herbert K, Goodall GJ, Speed Whitford EJ, Cummins AG, Butler RN, TP, Asou N, Jacob B, Osato M, Haylock Phillips PJ. A1c and Blood Glucose Fauser JK, Yazbeck R, Lawrence A, DN, Nilsson SK, D’Andrea RJ, Lopez AF, Testing – two sides of the same coin. Cheah KY, Prisciandaro LD, Howarth Guthridge MA. Expression profiling of a Conquest. Winter 2009; (June-August), GS. The new probiotic, Streptococcus hemopoietic cell survival transcriptome 8-9. thermophilus TH-4, reduces crypt implicates osteopontin as a functional fission in a rat model of 5-fluorouracil prognostic factor in AML. Blood. 2009 Phillips PJ, Close A. Home medicine induced mucositis. Cancer Biology Oct 5. [Epub ahead of print]. reviews Conquest. Winter 2009; Therapeutics .2009; 9:209-215. (June-August) 22-23. Perugini M, Kok CH, Brown AL, Abstracts Wilkinson CR, Salerno DG, Young Phillips PJ, Close A. Diabetes and Fon JT, Lidums I. Body Mass Index SM, Diakiw SM, Lewis ID, Gonda complimentary medicines. Conquest. influences Small Bowel transit time and TJ, D’Andrea RJ. Repression of Autumn 2009; 22-23. complteness of capsule endoscopy. Gadd45alpha by activated FLT3 and J Gastroenterol & Hepatol. 2009; GM-CSF receptor mutants contributes to Phillips PJ. Abnormal laboratory results. 24:A254. growth, survival and blocked differentia- Pitfalls in interpreting laboratory tion. Leukemia. 2009; 23:729-738. results. Australian Prescriber. 2009; Vol Fon JT, Lidums I. Diagnostic yield of 32. No.2, 43-46. capsule endoscopy for investigation Perugini M, Varelias A, Sadlon T, of obscure gastrointestinal bleeding in D’Andrea RJ. Hematopoietic growth the elderly. J Gastroenterol & Hepatol. factor mimetics: From concept to clinic. 2009; 24:A258. Cytokine and Growth Factor Reviews. GASTROENTEROLOGY 2009; 20:87-94. AND HEPATOLOGY UNIT Papers Raynor MP. Stephenson SA. Pittman KB. Cook AF, Grover PK, Ryall RL. HAEMATOLOGY AND Walsh DC. Henderson MA. Dobrovic A. Face-specific binding of prothrombin Identification of circulating tumour cells fragment 1 and human serum albumin MEDICAL ONCOLOGY, in early stage breast cancer patients to inorganic and urinary calcium using multi marker immunobead oxalate monohydrate crystals. British The combined RT-PCR. Journal of Haematology & Journal Urology International. 2009; Departments of Oncology. 2009; 2:24. 103:826-835. Papers Sukumaran S, Pittman KB, Patterson Eng HS, Bennett G, Bardy P, Coghlan P, WK, Dickson J, Yeend S, Townsend A, Cummins AG, Roberts-Thomson IC. Russ GR, Coates PT. Clinical significance Broadbridge V, Price TJ. A phase I study Prevalence of celiac disease in the of anti-HLA antibodies detected by to determine the safety, tolerability and Asia-Pacific region. Journal of Gastro- Luminex: enhancing the interpretation of maximum tolerated dose of green- enterology and Hepatology. 2009; CDC-BXM and important post-transplan- lipped mussel (Perna canaliculus) lipid 24:1347-1351. tation monitoring tools. Hum Immunol. extract, in patients with advanced 2009 Aug;70(8):595-9. Healy J, Alexander B, Eapen C, Roberts- prostate and breast cancer. Ann Oncol. 2009 Oct 21. [Epub ahead of print]. Thomson IC. Minocycline-induced Gibson NS, Schellong SM, El Kheir DY, autoimmune hepatitis. Internal Beyer J, Gallus AS, McRae S, Schutgens Townsend A, Price T, Karapetis C. Medicine Journal. 2009; 39:487-488. RE, Piovella F, Gerdes VE, Buller HR. Selective internal radiation therapy for TQEHresearch Research Report 2009 83 liver metastases from colorectal cancer. outcomes of elderly trauma patients JJ (NICE-SUGAR Study Investigators). Cochrane Database Syst Rev. 2009 Oct; admitted to Intensive Care and the Intensive versus conventional glucose 7:(4):CD007045. Review. general wards of an Australian tertiary control in critically ill patients. NEJM referral hospital. Anaesth Intensive Care 2009; 360:1346-9. (S Peake Principal Townsend A, Price T, Yeend S, Pittman K, .2009; 37(5):773-783. Investigator, The Queen Elizabeth Patterson K, Luke C. Metastatic Carcinoid Hospital). Tumor: Changing Patterns of Care Over Chen J, Bellomo R, Flabouris A, Hillman Two Decades. J Clin Gastroenterol. 2009 K, Finfer S; MERIT Study Investigators Rangappa P, Moran J. Outcomes of Jul 14. [Epub ahead of print]. for the Simpson Centre; ANZICS Clinical patients admitted to the intensive Trials Group. The relationship between care unit with idiopathic pulomanary Usman M, Price T, Laddipeerla N, early emergency team calls and serious fibrosis. Critical Care & Resuscitation Broadbridge Vy, Townsend A. Contrast adverse events. Crit Care Med. 2009; 2009; 11(2):102-109. induced hyperthyroidism due to ioine 37:148-53. excess. BMJ Case Reports 2009;1-5. Reade MC, Delaney A, Bailey MJ, Worthley DL, Johnson DF, Eisen DP, Chen J, Hillman K, Bellomo R, Harrison DA, Yealy DM, Jones PG, Dean MM, Heatley SL, Tung JP, Scott J, Flabouris A, Finfer S, Cretikos M Rowan KR, Bellomo R, Angus DC Padbury RT, Harley HA, Bardy PG, Angus (MERIT Study Investigators for the for the Australasian Resuscitation PW, Mullighan CG. Donor mannose- Simpson Centre; ANZICS Clinical Trials in Sepsis Evaluation (ARISE), United binding lectin deficiency increases Group). The impact of introducing Kingdom Protocolised Management the likelihood of clinically significant medical emergency team system on In Sepsis (ProMISE) and United States infection after liver transplantation. the documentations of vital signs. Protocolised Care for Early Septic Clinical Infectious Diseases. 2009 Resuscitation 2009; 80:35-43. (S Shock (ProCESS) Investigators. Prospec- Feb;15:48(4):410-7. Peake, Member, Steering Committee tive meta-analysis using individual and Principle Investigator,The Queen patient data in intensive care medicine. Worthley DL, Ruszkiewicz A, Davies Elizabeth Hospital). Intensive Care Med. 2009 Sep 18. R, Moore S, Nivison-Smith I, Bik To L, [Epub ahead of print]. (S Peake, Chair, Browett P, Western R, Durrant S, So J, Flabouris A, Chen J, Hillman K, Bellomo ARISE Management Committee). Young GP, Mullighan CG, Bardy PG, R, Finfer S (The MERIT Study Investiga- Michael MZ. Human gastrointestinal tors from the Simpson Centre and the Thomas MC, MacIsaac RJ, Jerums G, neoplasia-associated myofibroblasts ANZICs Clinical Trials Group). Timing Weekes A, Moran J, Shaw JE, Atkins can develop from bone marrow-derived and interventions of emergency teams RC. Nonalbuminuric renal impairment cells following allogeneic stem cell during the MERIT study. Resuscitation in type 2 diabetic patients and in the transplantation. Stem Cells. Jun 2009; 2009 Nov 12. [Epub ahead of print]. general population (National Evaluation 27(6):1463-8. (S Peake, Member, Steering Committee of the Frequency of Renal Impairment and Principle Investigator, The Queen cO-existing with NIDDM [NEFRON] 11) Abstracts Elizabeth Hospital). Diabetes Care. 2009; 32(8)1497-1502. Price TJ, Peeters M, Douillard J, Mitchell E, Cohn A, Strickland AH, Rivera F, Xu F, Ghelani DR, Moran JL, Sloggett A, Webb SA, Pettilä V, Seppelt I, Bellomo Gansert J, Siena S. Safety summary of Leeson RJ, Peake SL. Long term survival R, Bailey M, Cooper DJ, Cretikos M, Panitumumab (pmab) in combination of intensive care septic and hospital Davies AR, Finfer S, Harrigan PW, Hart with chemotherapy from 4 clinical trials patient cohorts compared with the GK, Howe B, Iredell JR, McArthur C, in patients with metastatic colorectal general Australian population: a relative Mitchell I, Morrison S, Nichol AD, cancer. J Clin Oncol. 2009; 27(suppl; survival approach. J Eval Clin Pract. Paterson DL, Peake S, Richards B, abstr e15005). 2009; 15(3):425-435. Stephens D, Turner A, Yung M (ANZIC Influenza Investigators). Critical care Tebbutt NC, Gebski V, Wilson K, Groop P-H, Thomas MC, Moran JL, services and 2009 H1N1 influenza in Cummins M, Chua Y, Robinson B, Waden J, Thorn LM, Makinen V-P Australia and New Zealand. N Engl J Broad A, Cunningham D, Simes J, Price Rosengard-Barlund M, Saraheimo M, Med. 2009 Nov 12;361(20):1925-34. T. International randomized Phase III Hietala K, Heikkila O Forsblom C. The study of Capecitabine, Bevacizumab, presence and severity of chronic kidney Webb SAR, Seppelt I (for the ANZIC and Mitomycin C in 1st line metastatic disease predicts all-cause mortality Influenza Investigators). Pandemic colorectal cancer. Final results of the in type 1 diabetes. Diabetes. 2009; (H1N1) 2009 influenza (“swine flu”) in AGITG MAX trial. J Clin Oncol. 2009; 5(7):1651-1658. Australian and New Zealand Intensive 27:15s (suppl; abstr 4023). Care. Critical care and resuscita- Finfer S, Chittock DR, Su SY, Blair D, tion. 2009; 11:170-172 (S Peake, Foster D, Dhingra V, Bellomo R, Cook SA representative, ANZIC Influenza D, Dodek P, Henderson WR, Hébert PC, Investigators). INTENSIVE CARE UNIT Heritier S, Heyland DK, McArthur C, Papers McDonald E, Mitchell I, Myburgh JA, Chan YL, Moran JL, Clarke C, Martin Norton R, Potter J, Robinson BG, Ronco J, Solomon PJ. Mortality and cost
TQEHresearch Research Report 2009 84 MEDICINE, University of Appleton SL, Ruffin RE, Wilson DH, person. Gastroenterol. Clin N Am. Taylor AW, Adams RJ. North West 2009; 38:393-409. Adelaide Discipline of Adelaide Cohort Health Study Team. Papers Cardiovascular disease risk associated Visvanathan R. Australia and New Adams RJ, Appleton SL, Wilson DH, with asthma and respiratory morbidity Zealand Society for Geriatric Medicine Taylor AW, Ruffin RE. Associations of might be mediated by short-acting Position Statement No 6 – Under- physical and mental health problems beta-2 agonists. J Allergy Clin Immunol. nutrition and the older person. Australa- with chronic cough in a representative 2009; 123(1):124-30,E1. sian Journal of Ageing. 2009; 28:99-105. population cohort. Cough. 2009 16 Dec; 5:10. Chapman IM, Visvanathan R, Hammond AJ, Morley JE, Field JBF, Tai Invited Reviews or Editorials Adams RJ, Appleton S, Hill C, Wilson K, Belobrajdic DP, Chen RYT, Horowitz Visvanathan R, Chapman I. Under- D, Taylor A, Dal Grande E, Chittlebor- M. Effect of testosterone and a nutrition and Anorexia In Older People ough C, Gill T, Ruffin RE. Independent nutritional supplement, alone and in in Gastroenterology In The Elderly-Ed. Association of HbA(1c) and incident combination of hospital admissions Talley & Tangalos. Gastroenterology cardiovascular disease in people without in undernourished older men and Medical Clinics of North America. diabetes. Obesity. (Silver Spring) 2009; women. Amer J Clin Nutr. 2009; 2009; 38(3):393-409. 17(3):559-63. 89:880-9. Visvanathan R. Nutritional Frailty: Adams RJ, Howard N, Tucker G, Chittleborough CR, Burke MJ, Taylor Unrecognized Threatens Independ- Appleton S, Taylor AW, Chittleborough AW, Wilson DH, Phillips PJ, Adams RJ, ence. Editorial Int J Evidence-based C, Gill T, Ruffin RE, Wilson DH. Effects Ruffin RE, and the North West Adelaide Healthcare. Volume 7 Issue 4 of area deprivation on health risks and Health Study Team. Medicare-related (December 2009) Editorial. outcomes: a multilevel, cross-sectional service use and costs among people Australian population study. Int J Pub with diagnosed and undiagnosed Visvanathan R. Under-nutrition and Health. 2009; 54L(3):183-92. diabetes and respiratory conditions. housebound older people. Nut & Diet. Australian Health Review. 2009; 2009 Dec; 66(4): 238-242. Adams RJ, Stocks NP, Wilson DH, Hill CL, 33(1):107-116. Gravier S, Kickbusch I, Beilby JJ. Health literacy – A new concept for general Kaiser MJ, Bauer HM, Pansch C, Uter practice? Aust Fam Physician. 2009; W, Guigoz Y, Cederholm T, Thomas DR, NEUROLOGY UNIT 38(3):144-7. Anthony P, Charlton KE, Maggio M, Papers Tsai AC, Grafhwohl D, Vellas B, Sieber Arthur A, Shi S, Zannettino AC, Fujii N, Adams RJ, Appleton SL, Hill CL, Dodd CC; MNA International Group. Valida- Gronthos S, Koblar SA. Implanted Adult M, Findlay C, Wilson DH. Risks associ- tion of the mini nutritional assessment Human Dental Pulp Stem Cells induce ated with low functional health literacy short-form (MNA-SF): A practical tool endogenous axon guidance. Stem Cells. in an Australian population. Medical J for identification of nutritional status. J 2009; 27(9):2229-37. Aust. 2009; 191:530-534. Nutr Health Aging. 2009; 13:782-788. Arthur A, Koblar SA, Shi S, Gronthos S. Adams RJ, Appleton SL, Wilson DH, Murgia C, Devirgiliis C., Mancini E, Eph/ephrinB mediated mobilization of Taylor AW, Chittleborough CR, Gill TK, Donadel G, Zalewski P.D., Perozzi G. Dental Pulp Stem Cell in tooth repair. Ruffin RE. Cholesterol lowering therapy Diabetes-linked zinc transporter ZnT8 Journal of Dental Research. 2009; and the Australian Pharmaceutical is a homodimeric protein expressed 88(9):829-34. Benefits Scheme: a population study. by distinct rodent endocrine cell types The Australian Health Review. 2009; in the pancreas and other glands Bousser MG, Amarenco P, Chamorro 33(2):325-33. Nutr Metab Cardiovasc. Dis. 2009; A, Fisher M, Ford I, Fox K, Hennerici 19(6):431-9. MG, Mattle HP, Rothwell PM; PERFORM Adams RJ, Tucker G, Price K, Hill CL, Study Investigators – Jannes J. Appleton SL, Wilson DH, Taylor AW, Ruffin RE. Time to Rethink Asthma Rationale and design of a randomized, Ruffin RE. Self-reported adverse events Management. Thorax. 2009; Dec double-blind, parallel-group study of in healthcare that cause harm: A 64(12):1013-1014. terutroban 30 mg/day versus aspirin population based survey. Med J Aust. 100 mg/day in stroke patients: the 2009 May 4;190(9):484-8. Tai K, Visvanathan R, Hammond AJ, prevention of cerebrovascular and Wishart JM, Horowitz M, Chapman cardiovascular events of ischemic origin Adams RJ, Appleton S, Hill CL, Ruffin IM. Fasting ghrelin is related to skeletal with terutroban in patients with a RE. Inadequate health literacy is associ- muscle mass in healthy adults. Eur J history of ischemic stroke or transient ated with increased asthma morbidity Nutr. 2009; 48:176-183. ischemic attack (PERFORM) study. in a population sample. Journal of Cerebrovasc Dis. 2009; 27(5):509-18. Allergy and Clinical Immunology. 2009; Visvanathan R, Chapman IM. Under 124:601-3. nutrition and anorexia in the older Price CJ, Blacker DJ, Grimley RS, Dewey HM, Gerraty RP, Koblar SA, Denisenko
TQEHresearch Research Report 2009 85 SM, Storey CE, Bladin CF, Hill KM. dressings in the acute care setting. Jardeleza C, Seiberling K, Floreani S, National survey of management of Wound Practice & Research. 2009; Wormald PJ. Surgical outcomes of transient ischaemic attack in Australia: 17(3): 146-52. endoscopic management of adenocar- Take Immediate Action. Me J Aust. cinoma of the sinonasal cavity. 2009; 191(1):17-20. Phillips P, Giles J. ‘Ten ways to stuff up Rhinology. 2009 Dec; 47(4):354-61. your medications’. Diabetes Network Abstracts News. 2009; 59:11. Jervis-Bardy J, Foreman A, Field Arthur A, Stylianou C, Koblar S, Matsuo J, Wormald PJ. Impaired mucosa K, Gronthos S. EphB/ephrin-B interac- Abstract healing and infection associated with tions assist in MSC niche maintenance Wright D, Kucia AM, Northey D, Ooi S.aureus following endoscopic sinus and contribute to bone remodelling K, Horowitz JD. Can an acute cardiac surgery. Am J Rhinol. Allergy. 2009 following injury. Bone Journal Australia. assessment nurse reduce time spent in Sep-Oct; 23(5):549-52. May 2009; 44(1):S142-S143. ED for patients presenting with chest pain? Heart, Lung and Circulation. Liu G, Shi Z, Kurigea T, Hanton LR, Djukic M, Koblar S, Lewis M, Hamilton- 2009; 18(3):S85. Simpson J, Moratti SC, Robinson RH, Bruce MA. Biomarker discovery Athanasiadis T, Valentine R, Wormald for transient ischaemic attack and Book PJ. Synthesis and characterisation of ischaemic stroke. The Queen Elizabeth Kucia AM. ‘Diagnostic testing’ in chitosan/dextran based hydrogels for Hospital Research Day Programme and B. Kozier, G. Erb, A. Bermann, S. surgical use. Macromol Symp. 2009; Abstracts. Adelaide October 2009; P-20. Snyder et al (Eds). 2009 Kozier & Erb’s 279:151-7. Fundamentals of Nursing, Pearson Lam A, Hamilton-Bruce M, Koblar S, Australia, NSW. Pant H, Beroukas D, Kette F, Smith W, Khoo EW, Patel S, Jannes J. Endothelial Wormald PJ. Nasal polyp cell popula- function in cerebral small vessel disease. tions and fungal-specific peripheral International Journal of Stroke. 2009; blood lymphocyte proliferation in 4(S1):2. OTOLARYNGOLOGY, allergic fungal sinusitis. Am J Rhinol HEAD AND NECK Allergy. 2009 Sep-Oct; 23(5):453-60. Lam A, Hamilton-Bruce MA, Khoo EW, Patel S, Koblar S, Jannes J. Endothelial SURGERY, Department of Pant H, Schembri MA, Wormald PJ, function in cerebral small vessel disease. Papers McCardle PJ. IgE mediated fungal The Queen Elizabeth Hospital Research Beule A, Athanasiadis T, Athanasiadis E, allergy in allergic fungal sinusitis. Day, Programme and Abstracts. Field J, Wormald PJ. Efficacy of different Laryngoscope. 2009; 119(6):1046-52. Adelaide October 2009; P-34. techniques of sinonasal irrigation after modified Lothrop procedure. Am J Rhinol Seiberling K, Floreani S, Robinson S, Leong WK, Lewis M, Gronthos S, Koblar Allergy. 2009 Jan-Feb; 23(1):85-90. Wormald PJ. Endoscopic management S. The therapeutic role of dental pulp of frontal sinus osteomas revisited. stem cells in improving functional Foreman A, Psaltis AJ, Tan LW, Wormald Am J Rhinol Allergy. 2009 May-June; recovery following ischaemic stroke – PJ. Characterization of bacterial and 23(3):331-6. cellular and molecular investigations. fungal biofilms in chronic rhinosinusitis. The Queen Elizabeth Hospital Research Am J Rhinol Allergy. 2009 Nov-Dec; Seiberling K, Jardeleza C, Wormald PJ. Day Programme and Abstracts. 23(6):556-61. Minitrephination of the frontal sinus: Adelaide 2009; P-36. Indications and uses in today’s era Foreman A, Singhal D, Psaltis AJ, of sinus surgery. Am J Rhinol Allergy. Leung ES, Hamilton-Bruce MA, Price C, Wormald PJ. Targeted imaging modality 2009 Mar-Apr; 23(2):229-31. Koblar SA. Transient Ischaemic Attack selection for bacterial biofilms in chronic (TIA) Knowledge in General Practice: rhinosinusitis. Laryngoscope. 2009 Nov Seiberling K, Ooi E, Miinyip J, Wormald a cross-sectional study of Western 30. [Epub ahead of print]. PJ. Canine fossa trephine for the Adelaide general practitioners. Interna- severely diseased maxillary sinus. tional Journal of Stroke. 2009; 4(1):22. Harris PK, Hussey DJ, Watson DI, Mayne Am J Rhinol Allergy. 2009 Nov-Dec; GC, Bradshaw A, Joniau S, Tan LW, 23(6):615-8. Wormald PJ, Carney AS. Reflux changes NURSING RESEARCH in adenoidal hyperplasia: a controlled Seiberling KA, Wormald PJ Case studies Papers prospective study to investigate its in the surgical management of nasal Giles J, Visentin K, Phillips P. Diabetes in aetiology. Clin Otolaryngol. 2009 Apr; airway obstruction. Otolaryngol Clin aged care. Australian Nursing Journal. 34(2):120-6. North Am. 2009; 119(6):1046-52. 2009 Feb; Vol 16(7):40. Humphreys K, Wormald P, Maddern G Seiberling K, Wormald PJ. The role McInnes WA. THE DRESSING BANK – a Upper airway surgery for adult sleep of Itraconazole in Recalcitrant Fungal system for providing access, equity and apnoea: what is the evidence? ANZ Sinusitis Am J Rhinol & Allergy. 2009 cost-effectiveness for advanced wound Journal of Surgery. 2009; 79(4):223-224. May-Jun; 23(3):331-6.
TQEHresearch Research Report 2009 86 Tan N, Floreani S, Robinson S, Nair S, Dhillon R, Bastiampillai T, Hong . An expanded criteria in Australia and New Sunkaraneni V, Faris C, Wormald PJ. unusual case of hospital-acquired Zealand, 1991 to 2005. Transplanta- Transillumination assisted maxillary infection: Legionella Longbeachae. tion. 2009; 87:1201-9. trephination – cadaver validation of a Australasian Psychiatry. 2009 Aug; new technique. Laryngoscope. 2009 17(4):337-8. Combe C, Albert JM, Bragg-Gresham Mar 5; 119(5):984-987. JL, Andreucci VE, Disney A, Fukuhara Price JR, Bastiampillai T, Dhillon RS. Is S, Goodkin DA, Gillespie BW, Saito Tan LW, Rogers J, Hatzirodos N, Baker depot medication safe in the setting of A, Jadoul M, Pisoni RL. The Burden L, Ooi EH, Wormald PJ. Immunomodu- myopathy? Aust N Z J Psychiatry. 2009 of Amputation Among Hemodialysis latory effect of cytosine-phosphate- Aug; 43(8):781-3. Patients in the Dialysis Outcomes guanosine (CpG)-oligonucleotides in and Practice Patterns Study (DOPPS). non-asthmatic chronic rhinosinusitis: Stead K, Kumar S, Schultz TJ, Tiver S, American Journal of Kidney Diseases. An explants model. Am J Rhinol Allergy. Pirone CJ, Adams RJ, Wareham CA. Teams 2009; 54(4):680-692. 2009 Mar-Apr; 23(2):123-9. communicating through STEPPS. Med J Aust. 2009; 190(11):S128-32. Coster DJ, Jessup CF, Williams KA. Thwin M, Weitzel E, McMains KC, Mechanisms of corneal allograft Athanasiadis T, Psaltis A, Field J, Wooden MDG, Air TM, Schrader GD, rejection and regional immunosuppres- Wormald PJ. Validating the use of Wieland B, Goldney RD. Frequent sion. Eye. 2009; (23)10:1894-7. report-derived Lund-McKay scores attenders with mental disorders at a Am J Rhinol Allergy. 2009 Jan-Feb; general hospital emergency depart- Craig JC, Webster AC, McDonald 23(1):33-5. ment. Emergency Medicine Australasia SP: The case of azathioprine versus 2009; 21:191–195. mycophenolate. Do different drugs Valentine R, Athanasiadis T, Moratti S, really cause different transplant Robinson S, Wormald PJ. The efficacy outcomes? Transplantation. 2009; of a novel chitosan gel on hemostasis 87:803-4. following endoscopic sinus surgery in a RENAL UNIT Papers sheep model of chronic rhinosinusitis. Edey M, Hawley CM, McDonald SP, Barraclough K, Hawley CM, McDonald Am J Rhinol Allergy. 2009 Jan-Feb; Brown FG, Rosman JB, Wiggins KJ, SP, Brown FG, Rosman JB, Wiggins KJ, 23(1):71-5. Bannister KM, Johnson DW. Entero- Bannister KM, Johnson DW. Coryne- coccal peritonitis in Australian perito- bacterium peritonitis in Australian Valentine R, Wormald PJ, Sidwani R. neal dialysis patients: predictors, peritoneal dialysis patients: predictors, Advances in Absorbable Biomaterials treatment and outcomes in 116 cases. treatment and outcomes in 82 cases. and Nasal Packing. Otolaryngol Clin N Nephrol Dial Transplant. 2009 Nov 30. Nephrol Dial Transplant. 2009 Dec; Am. 2009; 42:813-828. [Epub ahead of print]. PubMed PMID: 24(12):3834-9. 19948875. Valentine R, Wormald PJ. Nasal Brook NR, Gibbons N, Johnson DW, dressings after endoscopic sinus Eng HS, Bennett G, Bardy P, Coghlan Nicol DL. Outcomes of transplants from surgery: what and why? Curr Opin P, Russ GR, Coates PT. Clinical signifi- patients with small renal tumours, Otolaryngol Head Neck Surg. 2009 cance of anti-HLA antibodies detected live unrelated donors and dialysis Nov 12. [Epub ahead of print]. by Luminex: enhancing the interpre- wait-listed patients. Transpl Int. 2009 tation of CDC-BXM and important [Epub ahead of print]. Weitzel EK, McMains KC, Wormald PJ. post-transplantation monitoring tools. Comprehensive surgical management Hum Immunol. 2009 Aug; 70(8):595-9. Bonder CS, Sun WY, Matthews T, of the aerosinusitis patient. Current Cassano C, Li X, Ramshaw HS, Pitson Opin Otol. H&NS. 2009 Feb 17;11-7. Flechner S, Friend P, Campistol J, Weir SM, Lopez AF, Coates PT, Proia RL, M, Diekmann F, Russ G. De novo Vadas MA, Gamble JR. Sphingosine immunosuppression with mammalian kinase regulates the rate of endothelial target of rapamycin inhibitors and PSYCHIATRY, University progenitor cell differentiation. Blood. posttransplantation malignancy in 2009 Feb 26;113(9):2108-17. focus. Transplant Proc. 2009 Jul-Aug; of Adelaide Discipline of 41(6 Suppl):S42-4. Papers Brady JL, Mannering SI, Kireta S, Coates Bastiampillai T, Dhillon R, French PT, Proietto AI, Cowan PJ, D’Apice AJ, Lew Gallagher M, Jardine M, Perkovic V, TH.Clozapine use in treatment-resistant AM. Monoclonal antibodies generated by Cass A, McDonald S, Petrie J, Eris J: agitation in the setting of dementia. Aust DNA immunization recognize CD2 from Cyclosporine withdrawal improves N Z J Psychiatry. 2009 Jul; 43(7):689-90. a broad range of primates. Immunol Cell long-term graft survival in renal Biol. 2009 Jul; 87(5):413-8. transplantation. Transplantation. 2009; Bastiampillai T, Forooziya F, Dhillon 87:1877-83. R.Clozapine-withdrawal catatonia. Aust N Collins MG, Chang SH, Russ GR, Z J Psychiatry. 2009 Mar; 43(3):283-4. McDonald SP. Outcomes of transplanta- Garg S, Carroll RP, Walker RG, Ramsay tion using kidneys from donors meeting HM, Harden PN. Skin cancer surveil- TQEHresearch Research Report 2009 87 lance in renal transplant recipients: antigen DQ alpha heterodimers and between Dialysis Modality and re-evaluation of U.K. practice and human leucocyte antigen DR alleles in Mortality. J Am Soc Nephrol. 2009; comparison with Australian experience. tubulointerstitial nephritis and uveitis 20:155-163. Br J Dermatol. 2009 Jan; 160(1):177-9. syndrome. Nephrology. (Carlton). 2008 Dec;13(8):755-7 (omitted from 2008 Miles R, Hawley CM, McDonald SP, Howard K, Salkeld G, White S, Report). Brown FG, Rosman JB, Wiggins KJ, McDonald S, Chadban S, Craig JC, Cass Bannister KM, Johnson DW. Predictors A. The cost-effectiveness of increasing Li JY, Yong TY, Grove DI, Coates PT. and outcomes of fungal peritonitis kidney transplantation and home-based Late-onset and atypical presentation in peritoneal dialysis patients. Kidney dialysis. Nephrology. 2009; 14:123-132. of Pneumocystis carinii pneumonia in Int. 2009 Sep; 76(6):622-8. a renal transplant recipient. Clin Exp Howard K, White S, Salkeld G, Nephrol. 2009 Feb;13(1):92-5. Nesrallah GE, Suri RS, Moist LM, McDonald S, Craig J, Chadban S, Cass, Cuerden M, Groeneweg KE, Hakim A. Cost-effectiveness of screening and Li JY, Yong TY, Grove DI, Coates PT. R, Ofsthun NJ, McDonald SP, Hawley optimal management for diabetes, Successful control of Scedosporium C, Caskey FJ, Couchoud C, Awaraji C, hypertension and chronic kidney disease prolificans septic arthritis and probable Lindsay RM. International Quotidian to prevent end-stage kidney disease: a osteomyelitis without radical surgery in Dialysis Registry: annual report 2009. modelled analysis. Value Health. 2009 a long-term renal transplant recipient. Hemodial Int. 2009 Jul; 13(3):240-9. Oct 29. [Epub ahead of print]. Transpl Infect Dis. 2008; 10:63-5. (omitted from 2008 Report). Orr NI, McDonald SP, McTaggart Irving MJ, Johnson DW, McDonald S, S, Henning P, Craig, JC. Frequency, Walker RG, Frommer MS, Craig JC. Li JY, Yong TY, Jurisevic CA, Russ etiology and treatment of childhood Opinions on the Content and Effects GR, Grove DI, Coates PT, Disney AP. end-stage kidney disease in Australia of Clinical Practice Guidelines for CKD: Successful treatment of pulmonary and New Zealand. Pediatr Nephrol. A Survey of Nephrologists in Australia mucormycosis in a renal transplant 2009; 24:1719-26. and New Zealand. Am J Kidney Dis. recipient with limited pulmonary 2009; 53:1082-90. reserve by combined medical and O’Shea S, Hawley C, McDonald surgical therapy. Heart Lung Circ. 2009 S, Brown F, Rosman J, Wiggins K, Jessup CF, Mohanasundaram D, Mee Jun;18(3):226-8. Bannister K, Johnson D. Streptococcal C, Sun WY, Drogemuller C, Milner C, peritonitis in Australian peritoneal Sen S, Bonder CS and Coates PTH. Li JY, Yong TY, Rao MM, Coates PTH. dialysis patients: predictors, treatment Co-transplantation of rat endothe- Partial nephrectomy for renal cell and outcomes in 287 cases. BMC lial progenitor cells to enhance the carcinoma in an allograft kidney with Nephrology. 2009; 10:19. engraftment of pancreatic islets. limited functional reserve. Nephrol Dial Xenotransplantation. 2009; 16(5):412. Transplant Plus. 2009; 2:312-313. Pescovitz MD, Nezakatgoo N, Lorber MI, Nashan B, Tedesco-Silva H Jr, Johnson DW, Dent H, Hawley CM, Lim WH, Chang SH, Chadban SJ, Kasiske BL, de la Cruz FJ, Russ G, McDonald SP, Rosman JB, Brown FG, Campbell SB, Dent H, Russ GR, Campistol J, Keown PA. international Bannister KM, Wiggins KJ: Associa- McDonald SP. Interleukin-2 receptor Sirolimus Study Group. Prospective tions of dialysis modality and infectious antibody reduces rejection rates observational study of sirolimus as mortality in incident dialysis patients and graft loss in live-donor kidney primary immunosuppression after in Australia and New Zealand. Am J transplant recipients. Transplantation. renal transplantation. Transplantation. Kidney Dis. 2009; 53:290-7. 2009 Nov 27; 88(10):1208-13. 2009 Oct 27;88(8):1010-8.
Karamadoukis L, Ansell D, Foley RN, Lim WH, Coates PS, Russ GR, Coates Pilmore H, Dent H, Chang S, McDonald SP, Tomson CRV, Trpeski L, PT. Hyperparathyroidism and vitamin McDonald SP, Chadban SJ. Reduction Caskey FJ: Towards case-mix-adjusted D deficiency predispose to bone loss in in Cardiovascular Death After Kidney international renal registry compari- renal transplant recipients. Transplanta- Transplantation. Transplantation. sons: how can we improve data tion 2009 Sep15; 88(5):678-83. 2009 Dec 31. [Epub ahead of print]. collection practice? Nephrol. Dial. PubMed PMID: 20048695. Transplant. 2009; 24:2306-2311. Macdonald JA, McDonald SP, Hawley CM, Rosman J, Brown F, Wiggins KJ, Prasad S, Kireta S, Leedham E, Russ Levidiotis V, Chang S, McDonald S: Bannister K, Johnson DW. Recovery GR, Coates PT. Propagation and Pregnancy and maternal outcomes of renal function in end-stage renal characterisation of dendritic cells among kidney transplant recipients. failure--comparison between peritoneal from G-CSF mobilised peripheral J Am Soc Nephrol. 2009; 20:2433- dialysis and haemodialysis. Nephrol Dial blood monocytes and stem cells in 2440. Transplant. 2009; 24:2825-2831. common marmoset monkeys. J Immunol Methods. 2009 Nov 18. Li JY, Yong TY, Bennett G, Barbara McDonald SP, Marshall MR, Johnson [Epub ahead of print]. JA, Coates PT. Human leucocyte DW, Polkinghorne KR. Relationship
TQEHresearch Research Report 2009 88 Rogers NM, Jones TE, Morris RG. Vanrenterghem Y, Krämer BK, Abramo- Eye Disease. Corneal Allotransplanta- Frequently discordant results from wicz D, Oppenheimer F, Pietruck F, tion, Allergic Disease and Trachoma. therapeutic drug monitoring for Russ G, Karpf C, Undre N. Pharma- Springer, Berlin. digoxin – clinical confusion for the cokinetics for once- versus twice-daily prescriber. Int Med J. 2008 Nov 11. tacrolimus formulations in de novo [Epub ahead of print] (omitted from kidney transplantation: a randomized, 2008 report). open-label trial. Am J Transplant. 2009 RESPIRATORY MEDICINE Nov; 9(11):2505-13. UNIT Rogers NM, Lawton PD, Jose MD. Harris M, Smith BJ, Veale AJ, Esterman Indigenous Australians and living van Leeuwen MT, Grulich AE, Webster A, Frith PA, Selim P. Providing reviews kidney donation. N Engl J Med. 2009; AC, McCredie MR, Stewart JH, of evidence to COPD patients: 8;361(15):1513-6. McDonald SP, Amin J, Kaldor JM, controlled prospective 12-month trial. Chapman JR, Vajdic CM. Immunosup- Chronic Respriatory Disease. 2009; Rogers NM, Matthews TJ, Kausman pression and other risk factors for early 6(3):165-73. JY, Kitching RA, Coates PT. Review and late non-Hodgkin lymphoma after article: Kidney dendritic cells: their kidney transplantation. Blood. 2009 Jul McEvoy RD, Pierce RJ, Hillman D, role in homeostasis, inflammation and 16; 114(3):630-7. Esterman A, Ellis EE, Catcheside PG, transplantation. Nephrology. (Carlton). O’Donoghue FJ, Barnes DJ, Grunstein 2009; 14(7):625-35. van Leeuwen MT, Grulich AE, McDonald RR, Southcott AM. Australian trial of SP, McCredie MR, Amin J, Stewart non-invasive Ventilation in Chronic Rogers NM, Peh CA, Faull R, Pannell JH, Webster AC, Chapman JR, Vajdic Airflow Limitation (AVCAL) Study M, Cooper J, Russ GR. Transmission of CM. Immunosuppression and other Group. Nocturnal non-invasive nasal toxoplasmosis in two renal allograft risk factors for lip cancer after kidney ventilation in stable hypercapnic recipients receiving an organ from the transplantation. Cancer Epidemiol COPD: a randomised controlled trial. same donor. Transpl Infect Dis. 2008; Biomarkers Prev. 2009 Feb; 18(2):561-9. Thorax. 2009 Jul; 64(7):561-6. 10: 71-4. (omitted from 2008 report). Villar E, Polkinghorne KR, Chang SH, Smith BJ, Da Costa J. Evidence Based Rogers NM, Russ GR, Cooper J, Coates Chadban SJ, McDonald SP. Effect of medicine: commentary: basing PT. Immunophenotyping of interstitial type 2 diabetes on mortality risk associ- medication adjustment on fractional infiltrate does not distinguish between ated with end-stage kidney disease. exhaled nitric oxide did not prevent BK virus nephropathy and acute cellular Diabetologia. 2009 Sep 9. [Epub ahead asthma exacerbations. Evidence Based rejection. Nephrology. (Carlton). 2009; of print]. Medicine. 2009; 14:2009:8. 14(1):118-22. Yeates KE, Cass A, Sequist TD, Rumpsfeld M, McDonald SP, Johnson McDonald SP, Jardine MJ, Trpeski L, DW. Peritoneal Small Solute Clearance Ayanian JZ. Indigenous people in RHEUMATOLOGY UNIT Is Nonlinearly Related To Patient Australia, Canada, New Zealand and Hill CL, Gill TK, Appleton S, Cleland Survival In The Australian And New the United States are less likely to L, Taylor AW, Adams RJ. The use of Zealand Peritoneal Dialysis Patient receive renal transplantation. Kidney fish oil in the community: Results of Populations. Perit Dial Int. 2009 Int. 2009 Sep; 76(6):659-64. a population-based study. Rheuma- Nov-Dec;29(6):637-46. tology (Oxford) 2009; 48:441-2. Yong TY, Li JY, Amato L, Mahadevan K, Siva B, Hawley CM, McDonald SP, Phillips PJ, Coates PS, Coates PT. Pituitary Cole A, Gill T, Shanahan EM, Phillips P, Brown FG, Rosman JB, Wiggins involvement in Wegener’s granulo- Taylor AW, Hill CL. Is diabetes associ- KJ, Bannister KM, Johnson DW. matosis. Pituitary. 2008; 11(1):77-84. ated with shoulder pain or stiffness: Pseudomonas Peritonitis in Australia: (omitted from 2008 Report). Results from a population-based Predictors, Treatment, and Outcomes cohort study. J Rheumatol. 2009; in 191 Cases. Clin J Am Soc Nephrol. Abstracts 36:371-7. 2009; 4:957-964. Russ G. Where did we leave off in 2008? Conclusions from the 8th Lester S, Proudman S, Lee A, Hall C, Stewart JH, Vajdic CM, van Leeuwen International Symposium. Transplant McWilliams L, James M, Cleland L. MT, Amin J, Webster AC, Chapman JR, Proc. 2009 Jul-Aug; 41(6):S27-30. Treatment-induced stable, moderate McDonald SP, Grulich AE, McCredie reduction in blood cell counts correlate MRE: The pattern of excess cancer Book Chapter to disease control in early rheuma- in dialysis and transplantation. Coster DJ, Jessup CF, Williams KA. toid arthritis. Intern Med J. 2009; Nephrol Dial Transplant. 2009 Oct; Mechanisms of Corneal Allograft 39(5):296-303. 24(10):3225-31. Rejection and the Development of New Therapies. Book Chapter. In Limaye V, Walker J, Ahern M, Bardy P, Wlodarczyk Z, Squifflet JP, Ostrowski Reinhard T and Larkin F, Essentials in Cox S, Roberts-Thomson P, Lester S, M, Rigotti P, Stefoni S, Citterio F, Ophthalmology: Cornea and External Blumbergs P. Monozygotic twins with
TQEHresearch Research Report 2009 89 distinct forms of idiopathic inflamma- endoscopic treatments for gastro- tive jaundice secondary to a common tory myositis. Rheumatology. (Oxford) oesophageal reflux disease. Br J Surg. bile duct abscess: A delayed sequel 2009; 48(7):855-7. 2009; 96(2):128–136. of cholecystectomy. HPB Surgery. 2009; Article ID 628197, 3 pages, See also: Hill CL, in Discipline of Chisholm JA, Jamieson GG, Lally CJ, doi:10.1155/2009/628197. Medicine publications. Devitt PG, Game PA, Watson DI. The effect of obesity on the outcome of Garcea G, Breukink SO, Marlow NE, laparoscopic antireflux surgery. Maddern GJ, Barraclough B, Collier SURGERY, University of J Gastrointest Surg. 2009; NA, Dickingson IC, Fawcett J, Graham Adelaide Discipline of 13(6):1064–1070. JC. A systematic review of the impact Adams DH, Ruzehaji N, Greenwood of volume of hepatic surgery on JE, Campbell HD, Arkell R, Cowin Ciccocioppo A, Stephens JH, Hewett patient outcome. Surgery. 2009; AJ. Attenuation of Flightless I, an PJ, Rieger NA. Complete pathologic 145(5):467–475. actin-remodelling protein, improves response after preoperative rectal burn injury repair via modula- cancer chemoradiotherapy. ANZ J Garcea G, Nabi H, Maddern GJ. Russell tion of transforming growth factor Surg. 2009; 79(6):481–484. Strong and the history of reduced-size (TGF)-beta1 and TGF-beta3. Br J liver transplantation. World J Surg. Dermatol. 2009; 161(2):326–336. Dixon E, Armstrong C, Maddern 2009; 33(8):1575–1580. G, Sutherland F, Hemming A, Wei Ananda SS, McLaughlin SJ, Chen F, A, Sherman M, Moore M, McKay Garcea G, Ong SL, Dennison AR, Hayes IP, Hunter AA, Skinner IJ, Steel A, Urbach D, Labrie M, Gordon L, Berry DP, Maddern GJ. Palliation of MC, Jones IT, Hastie IA, Rieger NA, Barkun J, Lynn Quan M , Dowden malignant obstructive jaundice. Dig Shedda S, Compston DJ, Gibbs P. Initial S, Bigam D, Gallinger S. Develop- Dis Sci. 2009; 54(6):1184–1198. impact of Australia’s National Bowel ment of quality indicators of care for Garcea G, Ong SL, Maddern GJ. Cancer Screening Program. Med J Aust. patients undergoing hepatic resection Predicting liver failure following major 2009; 191(7):378–381. for metastatic colorectal cancer using hepatectomy. Dig Liver Dis. 2009; a Delphi process. J Surg Res. 2009; 41(11):798–806. Barkun JS, Aronson JK, Feldman LS, 156(1):32–38. Maddern GJ, Strasberg SM; Balliol Garcea G, Ong SL, Maddern GJ. The Collaboration, Altman DG, Barkun JS, Dowson H, Hewett P. Perspective on ‘is current role of PET-CT in the character- Blazeby JM, Boutron IC, Campbell WB, laparoscopic colectomy as cost-benefi- isation of hepatobiliary malignancies. Clavien PA, Cook JA, Ergina PL, Flum cial as open colectomy’. ANZ J Surg. HPB(Oxford). 2009; 11(1):4–17. DR, Glasziou P, Marshall JC, McCulloch 2009; 79(4):221-222. Garcea G, Chee W, Ong SL, Maddern P, Nicholl J, Reeves BC, Seiler CM, GJ. Preoperative biliary drainage for Meakins JL, Ashby D, Black N, Bunker Ergina PL, Cook JA, Blazeby JM, distal obstruction: the case against J, Burton M, Campbell M, Chalkidou K, Boutron I, Clavien PA, Reeves BC, Seiler revisited. Pancreas. 2009 Nov 23. Chalmers I, de Leval M, Deeks J, Grant CM; Balliol Collaboration, Altman [Epub ahead of print]. A, Gray M, Greenhalgh R, Jenicek M, DG, Aronson JK, Barkun JS, Campbell Kehoe S, Lilford R, Littlejohns P, Loke WB, Cook JA, Feldman LS, Flum DR, Hamer PW, Thompson SK, Rees GL, Y, Madhock R, McPherson K, Rothwell Glasziou P, Maddern GJ, Marshall JC, Devitt PG, Jamieson GG. Bilateral P, Summerskill B, Taggart D, Tekkis McCulloch P, Nicholl J, Strasberg SM, recurrent laryngeal nerve palsy after Ivor P, Thompson M, Treasure T, Trohler Meakins JL, Ashby D, Black N, Bunker Lewis oesophagectomy. [Letter]. ANZ U, Vandenbroucke J. Evaluation and J, Burton M, Campbell M, Chalkidou K, Journal of Surgery. 2009; 79 959–60. stages of surgical innovations. Lancet. Chalmers I, de Leval M, Deeks J, Grant 2009 Sep26;374(9695):1089–1096. A, Gray M, Greenhalgh R, Jenicek M, Harvey I, Smith S, Patterson I. The use Kehoe S, Lilford R, Littlejohns P, Loke of quilted full thickness skin grafts in Bruening MH, Maddern GJ. Rural Y, Madhock R, McPherson K, Rothwell the lower limb – reliable results with surgery: the Australian experience. Surg P, Summerskill B, Taggart D, Tekkis early mobilisation. J Plast Reconstr Clin North Am. 2009; 89(6):1325–1333. P, Thompson M, Treasure T, Trohler Aesthet Surg. 2009; 62(7):969–972. U, Vandenbroucke J. Challenges in Bucher C, Zuberbuhler B, Goggin M, evaluating surgical innovation. Lancet. Hoggan BL, Cameron AL, Maddern Esterman A, Schipper I. Corneal limbal 2009; 374(9695):1097–1104. GJ. Systematic review of endovenous marking in the treatment of myopic laser therapy versus surgery for the astigmatism with the excimer laser. Fagan A, Kennaway D, Oakley A, treatment of saphenous varicose veins. J Refract Surg. 2009 Sep 2. [Epub Pinealectomy in the chicken: a good Ann Vasc Surg. 2009; 23:277–287. ahead of print]. model of scoliosis? Eur Spine J. 2009; 18:1154–1159. Humphreys K, Wormald P, Maddern G. Chen D, Barber C, McLoughlin P, Upper airway surgery for adult sleep Thavaneswaran P, Jamieson GG, Fairhurst K, Strickland A, Bridgewater apnoea: what is the evidence? ANZ J Maddern GJ. Systematic review of FHG, Maddern GJ. Painless obstruc- Surg. 2009; 79(4):223–224.
TQEHresearch Research Report 2009 90 Kaufmann C, Krishnan A, Landers J, McCulloch P, Altman DG, Campbell review of permanent and semiperma- Esterman A, Thiel MA, Goggin M. WB, Flum DR, Glasziou P, Marshall nent dermal fillers for HIV-associated Astigmatic neutrality in baxial microin- JC, Nicholl J; Balliol Collaboration, facial lipoatrophy. AIDS Patient Care cision cataract surgery. J Cataract Aronson JK, Barkun JS, Blazeby JM, STDS. 2009; 23(9):699–714. Refract Surg. 2009; 35(9):1555–1562. Boutron IC, Campbell WB, Clavien PA, Cook JA, Ergina PL, Feldman LS, Flum Vandeweyer D, Neo EL, Chen JW, Kaufmann C, Thiel MA, Esterman A, DR, Maddern GJ, Nicholl J, Reeves BC, Maddern GJ, Wilson TG, Padbury Dougherty PJ, Goggin M. Astigmatic Seiler CM, Strasberg SM, Meakins JL, RT. Influence of resection margin change in biaxial microincisional Ashby D, Black N, Bunker J, Burton M, on survival in hepatic resections for cataract surgery with enlargement of Campbell M, Chalkidou K, Chalmers I, colorectal liver metastases. HPB. one incision: a prospective controlled de Leval M, Deeks J, Ergina PL, Grant (Oxford). 2009; 11(6):499–504. study. Clin Experiment Ophthalmol. A, Gray M, Greenhalgh R, Jenicek M, 2009; 37(3):254–261. Kehoe S, Lilford R, Littlejohns P, Loke Watt AM, Patkin M, Sinnott MJ, Black Y, Madhock R, McPherson K, Meakins RJ, Maddern GJ. Scalpel safety in the Kopecki Z, Arkell R, Powell BC, Cowin J, Rothwell P, Summerskill B, Taggart operative setting: A systematic review. AJ. Flightless I regulates hemidesmo- D, Tekkis P, Thompson M, Treasure T, Surgery. 2009 Oct 12. [Epub ahead some formation and integrin-mediated Trohler U, Vandenbroucke J. No surgical of print]. cellular adhesion and migration during innovation without evaluation: the wound repair. J Invest Dermatol. 2009; IDEAL recommendations. Lancet. 2009; Wang J, Kollias J, Marsh C, Maddern 129(8):2031–2045. 374(9695):1105–1112. G. Are males with early breast cancer treated differently from females Landers J, Goggin M. Comparison of Ng WT, Goggin M. Vitamin usage with early breast cancer in Australia refractive outcomes using immersion patterns. Ophthalmology. 2009; and New Zealand? Breast. 2009; ultrasound biomery and IOLMaster 116(4):819–820. 18(6):378–381. biometry. Clin Experiment Ophthalmol. 2009; 37(6):566–569. Perera CL, Bridgewater FH, Wang J, Kollias J, Boult M, Babidge Thavaneswaran P, Maddern GJ. Nonther- W, Zorbas HN, Roder D, Maddern Lauder C, Garcea G, Kanhere H, apeutic male circumcision: tackling G. Patterns of Surgical Treatment for Maddern GJ. Sclerosing haeman- the difficult issues. J Sex Med. 2009; Women with Breast Cancer in Relation giomas of the liver: Two cases of 6(8):2237–2243. to Age. Breast. 2009 Nov 2. [Epub mistaken identity. HPB Surgery. ahead of print]. 2009; Article ID 473591, 3 pages, Pham CT, Perera CL, Watkin DS, doi:10.1155/2009/473591. Maddern GJ. Laparoscopic ventral hernia repair: a systematic review. Surg Endosc. Leitch VD, Strudwick XL, Matthaei KI, 2009; 23:4–15. THERAPEUTICS Dent LA, Cowin AJ. IL-5-overexpressing RESEARCH CENTRE mice exhibit eosinophilia and altered Rieger NA, Lam FF. Single-incision Papers wound healing through mechanisms laparoscopically assisted colectomy using Mohamed F, Gawarammana I, involving prolonged inflammation. standard laparoscopic instrumentation. Robertson TA, Roberts MS, Palangas- Immunol Cell Biol. 2009; 87:131–140. Surg Endosc. 2009 Sep 16. [Epub ahead inghe C, Zawahir S, Jayamanne S, of print]. Kandasamy J, Eddleston M, Buckley Leopardi D, Hoggan BL, Fitridge RA, NA, Dawson AH, Roberts DM. Acute Woodruff PW, Maddern GJ. Systematic Roberts-Thomson IC, Teo E, Maddern Human Self-Poisoning with Imidacloprid review of treatments for varicose veins. GJ. Bile duct injuries associated with Compound: A Neonicotinoid Insecti- Ann Vasc Surg. 2009; 23(2):264–276. cholecystectomy. J Gastroenterol cide. PLoS ONE 2009; 4(4): e5127. Hepatol. 2009; 24(5):706–708. Ludbrook GL, Madden GJ. Doctor Roberts JA, Roberts MS, Robertson displacement: a political agenda or Roediger WEW, Cummins A, Cowled P. TA, Dalley AJ, Lipman J. Piperacillin a health care imperative? Comment. Mucosal barrier breakdown in ulcerative penetration into tissue of critically Med J Aust. 2009; 190(7):396–397. colitis: the case of nitrosothiols impairing ill patients with sepsis-bolus versus Maddern GJ. NOTES: progress or colonocytes. Gut. 2009; 58:A103. continuous administration? Crit Care marketing? ANZ J Surg. 2009; Med. 2009 Mar; 37(3):926-33. 79(5):318–319. Strickland A, Kanhere H, Fitridge R, Maddern G. Prognostic endovascular Chen X, Prow TW, Crichton ML, Maddern GJ, Karatassas A, Hensman scoring is useful for the assessment of Jenkins DW, Roberts MS, Frazer IH, C. Pain or gain: new innovations and patients with additional pathology. [Letter] Fernando GJ, Kendall MA. Dry-coated trends in hernia repair. ANZ J Surg. ANZ J Surg. 2009; 79(12):955–956. microprojection array patches for 2009; 79(11):778–780. targeted delivery of immunothera- Sturm LP, Cooter RD, Mutimer KL, peutics to the skin. J Control Release. Graham JC, Maddern GJ. A systematic 2009 Nov 3; 139(3):212-20.
TQEHresearch Research Report 2009 91 Li P, Wang GJ, Robertson T, Roberts MS. Monajjemzadeh F, Hassanzadeh D, Skin in vitro. J Pharm Sci. 2010 Feb; Liver transporters in hepatic drug disposi- Valizadeh H, Siahi-Shadbad MR, 99(2):712-8. tion: An update. Curr Drug Metab. Mojarrad JS, Robertson TA, Roberts 2009 Aug; 10(5):482-98. MS. Compatibility studies of acyclovir Fanning KF, Anissimov YG, Roberts MS. and lactose in physical mixtures and (2009) Sulphonylurea Physicochemical- Zhang Q, Grice JE, Wang GJ, Roberts commercial tablets. Eur J Pharm Pharmacokinetic Relationships in the MS. Cutaneous metabolism in Biopharm. 2009; 73(3):404-13. Pancreas and Liver. J Pharm Sci. 2009; transdermal drug delivery. Current 98(8) 2807-21. Drug Metabolism. 2009; 10:227-235. He S, Liu X, Yang Y, Huang W, Xu S, Yang S, Zhang X, Roberts MS (2009). Kaur S, Mitchell G, Roberts MS, Vitetta Dalley AJ, Lipman J, Deans R, Mechanisms of MAPK pathway L. Interventions that can reduce Venkatesh B, Rudd M, Roberts MS, mediating TGF-beta(1)/Smad signal in inappropriate prescribing in the elderly: Cross SE. Tissue accumulation of keloid fibroblasts. Br J Dermatol. 2009 A systematic review. Drugs & Aging. cephalothin in burns: A comparative September 2. [Epub ahead of print]. 2009; 26(12):1013-28. study by microdialysis of subcuta- PMID: 19772524. neous interstitial fluid cephalothin Liu X, Yang Y, Zhang X, Xu S, He S, concentrations in burn patients and Liu X, Wang JY, Khlentzos AM, Huang W, Roberts MS. Compound healthy volunteers. Antimicrob Agents Fontaine F, Nikolovski J, Goh LA, Astragalus and Salvia miltiorrhiza Chemother. 2009; 53(1)210-215. Roberts MS. Influence of perfusate extract inhibits cell invasion by composition on drug disposition in modulating transforming growth Dalley AJ, Deans R, Lipman J, the in-situ perfused rat lung. Int J factor-beta/Smad in HepG2 cell. Venkatesh B, Rudd M, Roberts MS, Pharm. 2009 Dec 1; 382(1-2):192-7. J Gastroenterol Hepatol. 2009 Sep Cross SE. Unbound Cephalothin 27. [Epub ahead of print]. PMID: Pharmacokinetics in Adult Burn Green B, Chandler S, MacDonald G, 19793165. Patients are Related to the Elapsed Elliott G, Roberts MS. Quantifying Pain Time after Injury. Antimicrob Agents Relief Following Administration Of A Xia CH, Sun JG, Wang GJ, Shang LL, Chemother. 2009; 53(12):5303-5. Novel Formulation Of Paracetamol Zhang XX, Zhang R, Peng Y, Wang XJ, (Acetaminophen). J Clin Pharmacol. Hao HP, Xie L, Roberts MS. Herb-Drug Yan J, Gong Y, She Y-M, Wang G, 2009 December 6. [Epub ahead of Interactions: In Vivo and In Vitro Effect Roberts MS, Burczynski FJ. Molecular print]. of Shenmai Injection, a Herbal Prepara- mechanism of recombinant liver fatty tion, on the Metabolic Activities of acid binding protein’s antioxidant Mutalik S, Hewavitharana AK, Shaw Hepatic Cytochrome P450 3A1/2, 2C6, activity. J Lipid Res 2009 May 28. [Epub PN, Anissimov YG, Roberts MS, 1A2, and 2E1 in Rats. Planta Med. ahead of print]. Parekh, HS. Development and valida- 2009 Sep 11. [Epub ahead of print]. tion of a reversed-phase high-perform- PMID: 19774504. Roberts JA, Kirkpatrick CMJ, Roberts ance liquid chromatographic MS, Robertson TA, Dalley AJ, Lipman method for quantification of peptide Monajjemzadeh F, Hassanzadeh D, J. Meropenem dosing in critically ill dendrimers in human skin permeation Valizadeh H, Siahi-Shadbad MR, patients with sepsis and without renal experiments. J Chromatogr B Analyt Mojarrad JS, Robertson T, Roberts MS. dysfunction – intermittent bolus vs Technol Biomed Life Sci. 2009 Nov 1; Assessment of feasibility of maillard continuous administration? Monte- 877(29):3556-62. reaction between baclofen and Carlo dosing simulations and subcuta- lactose by liquid chromatography and neous tissue distribution. J Antimicrob Anissimov YA, Roberts MS. Diffusion tandem mass spectrometry, applica- Chemother. 2009; 64(1):142-50. modelling of percutaneous absorption tion to pre formulation studies. AAPS kinetics: 4. Effects of a slow equilibra- PharmSciTech. 2009; 10(2):649-59. Park S, Ropella GEP, Kim SHJ, Roberts tion process within stratum corneum MS, Hunt CA. Computational Strategies on absorption and desorption kinetics. Book chapters Unravel and Trace How Liver Disease J Pharm Sci 2009; 98(2):772-81. Liu X, Kruger P, Roberts MS. Yearbook Changes Hepatic Drug Disposition. of Intensive Care and Emergency Computational Strategies Unravel Fanning KJ, Anissimov YG, Roberts Medicine. edit J.-L Vincent, Springer and Trace How Liver Disease Changes MS. Sulphonylurea physicochemical- Berlin 2009; P-859-869. Hepatic Drug Disposition. J Pharmacol pharmacokinetic relationships in the Exp Ther. 2009 Jan; 328(1):294-305. pancreas and liver. J Pharm Sci. 2009; 98(8):2807-21. Zhang Q, Grice JE, Li P, Jepps OG, Wang GJ, Roberts MS. Skin Solubility Grice JE, Ciotti SN, Weiner N, Determines Maximum Transepidermal Lockwood P, Cross SE, Roberts MS. Flux for Similar Size Molecules. Pharm Relative Uptake of Minoxidil into Res. 2009; 26(8):1974-85. Appendages and Stratum Corneum and Permeation through Human
TQEHresearch Research Report 2009 92 Invited Presentations at International and National Meetings
CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME
ANAESTHESIA, Department of 3rd Pan-Asian Nysora Symposium, Transverse Rectus Abdominis Myocutaneous (TRAM) flap breast V Rao Kadam Kuala Lumpur, Malaysia, February 2009 reconstruction – The use of Tranversus Abdominis Plane (TAP) block and paravertebral block – case report
CARDIOLOGY UNIT Heart Foundation Conference, Heterogeneity of L- and T-Channels in the Vasculature: an explanation C Ball, DP Wilson, Brisbane, Australia, May 2009 for the improved efficacy of combined L- and T-blockade S Turner, D Saint, JF Beltrame Heart Foundation Conference, Acute Simvastatin Treatment Attenuates Vascular Constriction via S Copley, JF Beltrame, Brisbane, Australia, May 2009 activation of Myosin Phosphatase DP Wilson Heart Foundation Conference, Acute Effects of Hydrophilic and Lipophilic Statins on Human IMA and N Ghaffari, J Edwards, Brisbane, Australia, May 2009 on Isolated Beating Heart Model JA Kennedy, JF Beltrame Heart Foundation Conference, Brisbane, Pravastatin and Microvascular Vasomotor Reactivity N Ghaffari, JA Kennedy, JF Australia, May 2009 Beltrame 6th International Meeting Intensive Cardiac Severe angina pectoris: beyond revascularisation JD Horowitz, P Pati, Care, Tel Aviv, Israel, A Sverdlov, RG Morris, October 2009 BC Sallustio, S Unger, JA Kennedy, JF Beltrame
57th Cardiac Society of Australia & New Prevalence of Coronary Slow Flow in Patients Undergoing Coronary L Jesuthasan, JF Beltrame, T Zealand, Sydney, Australia, August 2009 Angiogram in a Large Teaching Hospital Marwick European Society of Cardiology, Barcelona, Low 25-hydroxyvitamin D levels are associated with elevated plasma DTM Ngo, Spain, September 2009 ADMA and C-reactive protein concentrations: nexus with cardiovas- AL Sverdlov, JJ McNeil, cular disease JD Horowitz 57th Cardiac Society of Australia & New Impact of perhexiline therapy on left ventricular function and cardio- PK Pati, AL Sverdlov, Zealand, Sydney, August 2009 vascular events in patients with refractory congestive heart failure JD Horowitz (CHF) Heart Foundation Conference, Endothelin-1-mediated Vasoconstriction Involves Rapid Protein Kinase K Rajopadhyaya, Brisbane, Australia, May 2009 C and Sustained Rho Kinase Activation JF Beltrame, DP Wilson American Heart Association Scientific Sessions Plasma concentrations of asymmetric dimethylarginine (ADMA) AL Sverdlov, 2009, Orlando, USA, predict LV mass independent of afterload. Oral presentation at the DT Ngo, AK Nightingale, S November 2009 American Heart Association Scientific Sessions Rajendran, T Heresztyn, JD Horowitz Heart Foundation Conference, Quality of Life Outcomes in Chronic Stable Angina Patients Treated R Tavella, N Cutri, Brisbane, Australia, May 2009 with PCI or Medical Therapy JF Beltrame 57th Cardiac Society of Australia & New Plasma proteomic investigations identify novel oxidative and inflam- V Kopetz, M Penno, Zealand, Sydney, Australia, August 2009 matory proteins involved in the acute presentation of Coronary Slow P Hoffmann, Flow Patients JF Beltrame
CLINICAL PHARMACOLOGY UNIT Pharmacogenomics Cong, Hinxton, Impact of donor and recipient ABCB1 and CYP3A5 genetics on kidney JK Coller, AA Somogyi, USA, September 2009 transplant outcome BD Noll, GR Russ, PT Coates, RG Morris, BC Sallustio AACB, Brisbane, Australia, Reporting of drug concentrations: Mass or molar units? MP Doogue, SJ Bryant, RO September 2009 Fullinfaw, KF Ilett, JO Miners, RG Morris, GDR Jones ASCEPT NZ Section, Invited Plenary Lecture, Are therapeutic drug assay labs misleading clinical staff? Can we do it RG Morris Dunedin, New Zealand, September 2009 better? Improving Outcomes in Nephrology, Immunosuppressant drug monitoring RG Morris Melbourne, Australia, September 2009 ASCEPT Annual Scientific Meeting, Sydney, Pharmacogenetics of Renal Transplantation BC Sallustio Australia, December 2009 Belgium & Luxemburg Toxicology Society HPLC-MS/MS assay for the determination of Imatinib and its metabo- IS Westley Meeting, Leuven, Belgium, March 2009 lites CGP74588 concentrations in plasma
TQEHresearch Research Report 2009 93 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME ENDOCRINOLOGY UNIT 3rd International Congress on Prediabetes and Population attributable risk (PAR) of overweight and obesity on E Dal Grandea, T Gill, L Wyatt, the Metabolic Syndrome, Nice, France, chronic diseases: South Australian representative, cross-sectional data, CR Chittleborough, April 2009 2004—2006 PJ Phillips, AW Taylor 10th National Rural Health Conference Building and supporting a diabetes education workforce J Giles, K Visentin, Proceedings, Cairns, Australia, May 2009 P Phillips 3rd International Congress on Prediabetes and Development of Metabolic Syndrome affects Health-Related quality of P Phillips, K Baldock, the Metabolic Syndrome, Nice, France, life. Vol 1, Supplement 1, April 2009, A96 A Taylor April 2009 3rd International Congress on Prediabetes and Diabetes Incidence: Seven-Fold Risk among those with Metabolic A Taylor, K Baldock, the Metabolic Syndrome, Nice, France, Syndrome. Vol 1, Supplement 1, April 2009, A33 Prediabetes and the P Phillips April 2009 Metabolic Syndrome Abstract Book)
GASTROENTEROLOGY AND HEPATOLOGY UNIT Australian Gastroenterology Week, Sydney, The gut microflora of individuals with ulcerative colitis (remission or CT Christophersen, S Kang, Australia, October 2009 mild) differs from healthy individuals C McSweeney, M Morrison, I Roberts-Thomson, MA Conlon Australian Gastroenterology Week, Sydney, Aetiology of macroscopic gastritis detected during gastroscopy AM Chung, Australia, October 2009 AG Cummins Australian Gastroenterology Week, Sydney, Wnt expression during growth of the small intestine in infancy R Donato, IA Penttila, Australia, October 2009 AG Cummins Australian Gastroenterology Week, Sydney, Modulation of the intracellular redox state induces apoptosis in the JK Fauser, RN Butler, Australia, October 2009 Caco-2 cell line AG Cummins, GM Matthews, S Howarth Australian Gastroenterology Week, Sydney, The role of video capsule endoscopy in suspected coeliac disease I Lidums, Australia, October 2009 patients with positive coeliac serology AG Cummins, E Teo Australian Gastroenterology Week, Sydney, Video capsule endoscopy findings in coeliac disease after 12 months I Lidums, Australia, October 2009 on a gluten-free diet AG Cummins, E Teo Australian Gastroenterology Week, Sydney, Emu oil increases crypt depth but only minimally affects other indictors S Mashtoub, RJ Lindsay, Australia, October 2009 of colonic integrity in a rat model of colitis KA Lymn, TWV Acott, R Yazbeck, AG Cummins, RN Butler, GS Howarth 14th International Congress of Mucosal Breast milk regulates intestinal and immune development during food IA Penttila, R Grose, Immunology, Boston, USA, July 2009 challenge in rats genetically predisposed to allergy K Lymn, AG Cummins, K Tooley Australian Gastroenterology Week, Sydney, Performance and establishment of a learning curve with white light R Singh, YM Bhat, Australia, October 2009 endoscopy vs narrow band imaging in diminutive colorectal polyps PH Thurairajah, R Walmsey, M Bourke, A Moss, R Chen, P Bampton, I Roberts-Thomson, N Nguyen, M Schoeman, G Nind, G Tucker, W Tam
GYNAECOLOGY, Department of Continence Foundation of Australia, Annual The effect of vaginal topical oestrogen replacement on female sexual C Barry (Chairman, convenor, Scientific Meeting, Adelaide, Australia, function presenter) November 2009
HAEMATOLOGY AND MEDICAL ONCOLOGY, The combined Departments of HAA 2009 Annual Scientific Meeting, Paraproteinemia and Coagulation Disorders S McRae Adelaide, Australia, August 2009 AIMS 2009, Adelaide, Australia, BloodSafe: SA Transfusion Practice Improvement Program K Robinson October 2009 HAA 2009 Annual Scientific Meeting, Pre-operative Iron Deficiency Anaemia K Robinson Adelaide, Australia, August 2009 HAA 2009 Annual Scientific Meeting, Consent for Transfusion K Robinson Adelaide, Australia, August 2009
INTENSIVE CARE UNIT ACCCN Institute of Continuing Education (ICE) Infection Control in the Intensive Care Unit B Grealy conference Hobart, Australia, May 2009 ACCCN Institute of Continuing Education (ICE) MRO Surveillance and Management in ICU B Grealy conference Hobart, Australia, May 2009
TQEHresearch Research Report 2009 94 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME Australian Society of Anaesthetists National Obesity and OSD in the ICU setting SL Peake Scientific Congress, Darwin, Australia, September 2009 Australian Society of Anaesthetists National The tale of two practices; Liberal and restrictive perioperative fluid SL Peake Scientific Congress Darwin, Australia, management September 2009 Intensive Care Research Co-ordinators Interest Applying for an Intensive Care Foundation Grant SL Peake Group (IRCIG) Meeting Noosa, Australia, March 2009
MEDICINE, University of Adelaide Discipline of Pharmacy Community Forum, Adelaide, Inhaled corticosteroids and long-acting Beta2 Agonists in asthma and RE Ruffin Australia, August 2009 COPD Sydney University Nutrition Research Founda- Under-nutrition and the Older Person. Ageing At Home: Nutrition R Visvanathan tion Committee on Nutrition For Older and Other Aspects. (keynote speaker) Australians, Sydney, Australia, June 2009 International Society for zinc Biology, Zinc and NF-KB, where inflammation meets apoptosis PD Zalewski Jerusalem, November 2009 (co chair session)
NEUROLOGY UNIT Poster Australian Stroke Genetics Collaboration, Biomarker discovery for transient ischaemic attack and ischaemic M Djukic, M Lewis, 6th Asia Pacific Conference Against Stroke & stroke MA Hamilton-Bruce, Stroke Society of Australasia Annual General SA Koblar Meeting, Cairns, Australia, September 2009 University of Adelaide Faculty of Health Biomarker discovery for transient ischaemic attack and ischaemic M Djukic, M Lewis, Sciences Postgraduate Research Expo, National stroke MA Hamilton-Bruce, Wine Centre of Australia, Adelaide, South SA Koblar Australia, September 2009 Centre for Stem Cell Research Annual A biological interface for cortical microstimulation K Ellis, M Lewis, Meeting, School of Molecular and Biomedical D O’Carroll, SA Koblar Science Symposium, Adelaide, Australia, November 2009 Centre for Stem Cell Research Annual Investigation into the role of Npas4 in neurogenesis T Klaric, M Lewis, Meeting, School of Molecular and Biomedical M Whitelaw, Science Symposium, Adelaide, Australia, SA Koblar November 2009 Centre for Stem Cell Research Annual Investigation into the role of Npas4 in neurogenesis T Klaric, M Lewis, Meeting, School of Molecular and Biomed- M Whitelaw, ical Science Symposium National Centre, SA Koblar December 2009 Centre for Stem Cell Research (CSCR) Annual The therapeutic role of dental pulp stem cells in improving functional WK Leong, T Henshall, A Scientific Meeting. Adelaide, Australia, outcome following ischaemic stroke Arthur, S Gronthos, M Lewis, November 2009 SA Koblar University of Adelaide School of Molecular The therapeutic role of dental pulp stem cells in improving functional WK Leong, and Biomedical Science Research Symposium, outcome following ischaemic stroke T Henshall, A Arthur, Adelaide, Australia, December 2009 Image S Gronthos, M Lewis, competition (winner of Open Science SA Koblar category) Stroke Society of Australasia, Annual Scientific Transient Ischaemic Attack (TIA) Knowledge in General Practice: a ES Leong, MA Hamilton- Meeting, Cairns, Australia, September 2009 cross-sectional study of Western Adelaide general practitioners Bruce, C Proce, SA Koblar Platform The Queen Elizabeth Hospital Research Day, Proteomic and genomic investigations in transient ischaemic M Djukic, M Lewis, Adelaide, Australia, October 2009 attack – Pilot Study MA Hamilton-Bruce, SA Koblar University of Adelaide, Discipline of Physiology A biological interface for cortical microstimulation K Ellis Seminar Adelaide, Australia, October 2009 Victor Chang Developmental Biology Seminar T Klaric, M Lewis, Series, Bionomics Journal Club, Discipline of M Whitelaw, SA Koblar Genetics Seminar Series, November 2009 The Queen Elizabeth Hospital Research Day, Endothelial function in cerebral small vessel disease A Lam, MA Hamilton-Bruce, Adelaide, Australia, October 2009 EW Khoo, S Patel, SA Koblar, J Jannes
TQEHresearch Research Report 2009 95 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME 6th Asia Pacific Conference Against Stroke Endothelial function in cerebral small vessel disease A Lam, MA Hamilton-Bruce, & 20th Stroke Society of Australasia Annual EW Khoo, S Patel, SA Koblar, Meeting, Cairns, Queensland, J Jannes September 2009 The Queen Elizabeth Hospital Research Day, The therapeutic role of dental pulp stem cells in improving functional WK Leong, Adelaide, Australia, October 2009 outcome following ischaemic stroke T Henshall, A Arthur, S Gronthos, M Lewis, SA Koblar The Queen Elizabeth Hospital, Division of Behavioural and Psychological Symptoms of Dementia: A Case Study C Short, G Berce, Medicine Medical Round, Adelaide, Australia, from The Memory Unit K Boundy, J Phillips, May 2009 E McGrath
NUCLEAR MEDICINE UNIT Australian and New Zealand Society of Nuclear Detection and correction of different detector sensitivities in multi- L Barnden, B Crouch, Medicine Annual Scientific Meeting, Sydney, head SPECT gammacameras D Badger Australia, April 2009 Australian and New Zealand Society of Nuclear A subtraction and 3D display program for the assessment of L Barnden, D Badger Medicine Annual Scientific Meeting, Sydney, Pulmonary Embolism in SPECT V/Q scans Australia, April 2009 Australian and New Zealand Society of Nuclear Improvements to the measurement of absolute cortical bloodflow and L Barnden Medicine Annual Scientific Meeting, Sydney, its application to multi-head cameras: A feasibility study Australia, April 2009 IACFS/ME; Reno, Nevada, USA, March 2009 The severity of Chronic Fatigue Syndrome correlates with changes in L Barnden, B Crouch, brain Magnetic Resonance (MR) images R Burnet, A Mernone, R Kwiatek, P DelFante Australian and New Zealand Society of V/Q SPECT Scan With Quantitative Subtraction Using QONSUB C Chew, L Barnden, Nuclear Medicine Annual Scientific Meeting, S Unger, T Trinh Sydney, Australia, April 2009 Australian and New Zealand Society of Nuclear A SPECT study of regional cerebral blood flow in mild cognitive B Crouch, L Barnden, Medicine Annual Scientific Meeting, Sydney, impairment (MCI) R Casse, N Liau Australia, April 2009 Australian and New Zealand Society of Nuclear Pulmonary vein stenosis after RF ablation diagnosed on a V/Q scan – a R Edwards Medicine Annual Scientific Meeting, Sydney, case study Australia, April 2009 Australian and New Zealand Society of Nuclear An I-123 Iodo-dexetimide SPECT Study of Acetylcholine Neuro- E Goble, L Barnden, Medicine Annual Scientific Meeting, Sydney, receptors in Post Traumatic Stress Disorder (PTSD) R Casse Australia, April 2009 Australian and New Zealand Society of Nuclear Incidental finding of breast cancer during myocardial perfusion D Maglica Medicine Annual Scientific Meeting, Sydney, imaging – a case study Australia, April 2009 Australian and New Zealand Society of Nuclear The value of myocardial perfusion cine review in the diagnosis of a G Pandos Medicine Annual Scientific Meeting, Sydney, liver cyst – a case study Australia, April 2009
NURSING RESEARCH Alcohol, Tobacco and other drugs: Nursing, Triage: What do I do right now? J Kenny Midwifery & Aboriginal Health Worker Practicum, Adelaide, Australia, August 2009 Country Health SA Allied Health Forum, Many varieties, great blend Multiplier Effect: A model for health J Giles, K Visentin Barossa, Australia, April 2009 professional development 10th National Rural Health Conference, Cairns, Building and supporting a diabetes education workforce J Giles, K Visentin, Australia, April 2009 P Phillips Australian Diabetes Educators Association Working together on nutrition advice L Green, T Lehmann, Annual Scientific Meeting, Adelaide, Australia, T Bennett, J Giles August 2009 Australian Diabetes Educators Association Waist circumference measurement: A comparison of technique and M Hodgson, R Cox Annual Scientific Meeting, Adelaide, Australia, operator August 2009 6th International Meeting of Intensive Cardiac ICCU nursing on the doorstep: the case for nursing input into triage of AM Kucia Care.Tel Aviv, Israel.October 2009. cardiac emergencies 6th International Meeting of Intensive Cardiac Takotsubo cardiomyopathy: What causes it? How do we diagnose it? AM Kucia on behalf of the Care.Tel Aviv, Israel.October 2009. Cardiology Unit, Queen Elizabeth Hospital and Vascular Therapeutics Group
TQEHresearch Research Report 2009 96 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME Australian Diabetes Educators Association Caring for children and adolescents with type 1 diabetes in rural K Visentin, Annual Scientific Meeting, Adelaide, Australia, setting M Lambert, J Giles August 2009 Health in Transition: Researching for the Diabetes in transition: A model for building local capacity K Visentin, J Giles, future. 4th International Conference on P Phillips Community Health Nursing Research, Adelaide, Australia, August 2009 Inaugural Nephrology Educators Symposium, Presentation titled Workshops – old hat or still useful in providing C Wilden Adelaide, Australia, July 2009 professional development for nurses 57th Annual Scientific Meeting of the Cardiac Can an Acute Cardiac Assessment Nurse reduce the time spent in ED D Wright, AM Kucia Society of Australia and New Zealand, Sydney, for patients presenting with chest pain? Australia, August 2009
OTOLARYNGOLOGY, HEAD AND NECK SURGERY, Department of Functional Endoscopic Sinus Surgery Course, Frontal Sinus Anatomy, Surgical approaches, Axillary Flap, Frontal PJ Wormald Tokyo, Japan January 2009 recess, Vidian Neurectomy, Endoscopic Pituitary Surgery, CSF Leak Closure - “Bath Plug Technique ”Modified Endoscopic Lothrop (MEL) Principles, Clivus, Sphenoid, ITF 5th Jakarta International FESS (JiFESS) Course Frontal Sinus Anatomy, Surgical approaches, Axillary Flap and PJ Wormald & Workshop, Jakarta, March 2009 approached to the Frontal recess, Dacryocystorhinostomy Anatomy and technique, Vidian Neurectomy, Endoscopic Pituitary Surgery, Skull base repair, Modified Endoscopic Lothrop (MEL) Principles, Transnasal Endoscopic Iintracranial Surgery Australasian Society of Otolaryngology Head Management of sinonasal polyposis, Controversies in frontal sinus PJ Wormald & Neck Surgery, Surfers Paradise, Australia, surgery – Panel May 2009 Endoscopic Sinus Surgery Course, Winchester, Frontal Sinus Anatomy, Surgical approaches Axillary Flap, Frontal PJ Wormald United Kingdom, June 2009 recess Dacryocystorhinostomy, Anatomy and technique, Vidian Neurectomy, Endoscopic Pituitary Surgery, CSF Leak Closure - “Bath Plug Technique,”Modified Endoscopic Lothrop (MEL) Principles, Clivus, Sphenoid, ITF Panel Discussion Skull Base Course, Brisbane, Australia, Preparing the skull base for craniofacial resection (Lothrop, sphenoi- PJ Wormald June 2009 dotomies and ethmoidal ligation) 2009 Beijing Functional Endoscopic Sinus Biofilms in chronic rhinosinusitis and healing and altering healing PJ Wormald Surgery Course, Beijing, China, after sinus surgery, Endoscopic approaches for the Frontal Sinus, August 2009 Modified Lothrop and Endoscopic anterior cranial fossa surgeries, Dissection demonstration; frontal sinus and modified Lothrop 3rd Asia Pacific Rhinology Innovative Leaders Biofilms in Chronic Rhinosinusitis and healing and altering PJ Wormald (APRIL) Forum on Advanced Functional healing after sinus surgery, Endoscopic Sinus Surgery, Endoscopic Endoscopic Sinus Surgery & Endoscopic Sinus approaches for the frontal sinus, modified Lothrop and Endoscopic Surgery, Hong Kong, August 2009 Anterior Cranial Fossa Surgeries, Endoscopic Sinus Surgery Frontal sinus, Modified Lothrop, Infra-temporal Fossa; Anterior Cranial Fossa demonstration Australasian Society of Clinical Immunology Bacterial biofilms and advanced surgery PJ Wormald & Allergy - 20th Annual Scientific Meeting, Adelaide, Australia, September 2009 55th American Rhinologic Society Meeting, 5th Annual David W. Kennedy Lecture: Invited Guest speaker: The PJ Wormald San Diego USA, October 2009 Frontal Sinus, How I do it, Session on Modified Endoscopic Lothrop Procedure or Draf III Procedure American Academy of Otolaryngology Head Biofilms in Chronic Sinusitis (Mini Seminar + Instructional Course), PJ Wormald & Neck Society Meeting, San Diego USA, An Endoscopic Approach to Tumors of the Intra-temporal Fossa, October 2009 Powered Endoscopic Dacryocystorhinostomy, Improving outcomes in Functional Endosocpic Sinus surgery, SS: tips from revision surgeons Irish Otolaryngology Head & Neck Society Honoured Guest to give the “Sir William Wilde Discourse”: The PJ Wormald 50th Anniversary, Cork, Ireland, frontal sinus. Invited Guest Speaker Rhinology Plenary Session: “The October 2009 Philosophy of FESS” Recalcitrant CRS - why does well performed sinus surgery fail? Neurosurgical Society of Australasia “Pituitary Surgery: Management of complex cases and recent PJ Wormald Workshop, Melbourne, Australia, developments workshop” - Invited Guest Speaker October 2009 12th Advanced Functional Endoscopic Sinus The anatomy and endoscopic approaches to the frontal recess, PJ Wormald Surgery Course, Adelaide, Australia, Review of CT scans with reconstruction of the anatomy of the frontal November 2009 recess, Frontal recess dissection, Sphenopalatine artery ligation and Vidian neurectomy dissection, Dacryocystorhinostomy dissec- tion, Modified endoscopic Lothrop dissection, Skull base dissection, Surgical field Panel discussion Australasian Society of Otolaryngology Head Biofilms in CRS: A FISH study A Foreman & Neck Surgery, Surfers Paradise, Australia, May 2009
TQEHresearch Research Report 2009 97 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME Australasian Society of Otolaryngology Head & Biofilms and superantigens in CRS A Foreman Neck Surgery, Adelaide, Australia, August 2009 American Rhinologic Society, San Diego, CA, Characterisation of Bacterial and Fungal Biofilms in CRS A Foreman USA, October 2009 The Queen Elizabeth Hospital Research Day, Do S. aureus biofilms contribute to Chronic Rhinosinusitis A Foreman Adelaide, Australia, October 2009 pathogenesis? Surgical Research Society of Australia, Annual Do S. aureus biofilms contribute to Chronic Rhinosinusitis A Foreman Scientific Meeting, Adelaide, Australia, pathogenesis? November 2009 12th Advanced Functional Endoscopic Sinus Role of biofilms in Chronic Rhinosinusitis A Foreman Surgery Course, Adelaide, Australia, November 2009 Australasian Society of Otolaryngology Head & Impaired mucosal healing and infection associated with S.aureus J Jervis-Bardy Neck Surgery, Surfers Paradise, Australia, following endoscopic sinus surgery May 2009 European Operating Room Nurses Association, Nurse Practitioner: Bridging the Gap Down Under T Nicholls Copenhagen, Sweden, April 2009 13th Otorhinolaryngology Head & Neck Nurses Peri Operative Nurse Practitioner: ENT T Nicholls Group (OHNNG) National Conference, Gold Coast, Australia, May 2009 Medtronic ENT Perioperative Nurses Day, Premiers Scholarship: USA T Nicholls Melbourne, Australia, October 2009 12th Advanced Endoscopic Dissection Course, FESS made Functional T Nicholls Adelaide, Australia, November 2009 Australasian Society of Otolaryngology Head & Post Surgical Outcomes of Endoscopic Sinus Surgery, done for chronic D Singhal Neck Surgery, Surfers Paradise, Australia, Rhinosinusitis associated with Biofilms May 2009 American Rhinologic Society, San Diego, CA, Impact of Biofilms on outcomes of Endoscopic Sinus Surgery D Singhal USA, October 2009 Proteomics Forum Berlin, Germany, Aberrant host mucin glycosylation patterns increase bacterial biofilm LW Tan March - April 2009 formation in respiratory disease Annual Australian Society for Otolaryngology Is nasal lysozyme effective in killing fungi? LW Tan Head and Neck Surgery Conference, Gold Coast, Australia, May 2009 Qiagen, Hilden, Germany, April 2009 Increased susceptibility to bacterial biofilm associated respiratory LW Tan diseases are influenced by aberrant glycosylation patterns of host mucin glycoproteins Australasian Society of Otolaryngology Head & Efficacy of a novel chitosan gel on haemostasis following endoscopic R Valentine Neck Surgery, Surfers Paradise, Australia, sinus surgery in the sheep model of CRS May 2009 Australasian Society of Otolaryngology Head & Modulation of wound healing post endoscopic sinus surgery R Valentine Neck Surgery, Surfers Paradise, Australia, May 2009 55th American Rhinologic Society Meeting, Efficacy of a novel chitosan gel on haemostasis and wound healing R Valentine San Diego USA, October 2009 following endoscopic sinus surgery 12th Advanced Functional Endoscopic Sinus Manipulation of wound healing R Valentine Surgery Course, Adelaide, Australia, November 2009
PSYCHIATRY, University of Adelaide Discipline of Mt Lofty Psychiatry Symposium, Depression & Cardio-Vascular Disorder: Recent Work from G Schrader Adelaide, July 2009 South Australia
RENAL UNIT Dialysis and Nephrology Transplant Workshop, Cutaneous squamous cell cancer after renal transplantation: R Carroll Lorne, Australia, March 2009 management of immunosuppression Roche Symposium Adelaide, Australia, Squamous cell cancer after transplantation R Carroll Oct 2009 Transplantation Society of Australia and New High numbers of FOXP3+ T cells and poor lymphocyte proliferation R Carroll Zealand Meeting, Canberra, Australia, identifies patients at risk of developing squamous cell carcinoma after June 2009 renal transplantation American Transplant Congress Boston, USA, High Numbers of FOXP3+ T Cells and Poor Lymphocyte R Carroll May 2009 Proliferation Identifies Patients at High Risk of Developing Squamous Cell Cancer after Renal Transplantation
TQEHresearch Research Report 2009 98 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME Transplantation Society of Australia and New Symposium lecture: The Highly Sensitised Patient PT Coates Zealand Meeting, Canberra, Australia, June 2009 Roche National Transplant Symposium, Clinical significance of anti-HLA antibodies in PT Coates Melbourne, Australia, July 2009 renal transplantation Australian and New Zealand Society of Kidney transplant outcomes among the Maori and pacific peoples of M Collins Nephrology. Hobart, Australia, New Zealand September 2009 Annual CITR Meeting Miami Florida, USA, The current status of the Adelaide Islet Transplantation program C Drogemuller March 2009 Transplantation Society of Australia and New Variability of zinc transporter gene expression in isolated human islets C Drogemuller Zealand Meeting, Canberra, Australia, in particular ZIP14 and the ß-cell specific ZnT8 June 2009 International Pancreas and Islet Transcriptome analysis of isolated human pancreatic islets expression C Drogemuller Transplantation Association Venice, profiles of zinc transporter genes in particular genes in particular ZnT8 Italy, October 2009 and ZIP14, critical islet maker genes and glucose metabolic gene Australian Society for Medical Research Adenovirus-Mediated Transduction of Pancreatic Islets using Insulin- A Hughes Adelaide, Australia, June 2009 like Growth Factor-II (IGF-II) to Prevent Apoptosis Transplantation Society of Australia and New Adenovirus-mediated transduction of pancreatic islets using insulin- A Hughes Zealand Meeting, Canberra, Australia, like growth factor-II to prevent apoptosis June 2009 Australian Diabetes Society (ADS) Meeting, Transgenic expression of insulin-like growth factor-II (IGF-II) in Adelaide, Australia, August 2009 pancreatic islets to prevent apoptosis Australasian Society for Immunology, Adelaide, Investigation of cytokine-induced early apoptosis in isolated islets of A Hughes Australia, September 2009 Langerhans The University of Oxford, Weatherall Institute, Optimal Delivery of Therapeutic Genes to Pancreatic Islets A Hughes Oxford, UK, October 2009 International Pancreas and Islet Transgenic expression of insulin-growth factor-II (IGF-II) in pancreatic A Hughes Transplantation Association Venice, Italy, islets to prevent apoptosis October 2009 Transplantation Society of Australia and New Characterisation of rat endothelial progenitor cells (EPC) as a novel C Jessup Zealand Meeting, Canberra, Australia, cellular therapy to enhance the engraftment of pancreatic islets June 2009 International Pancreas and Islet Transplantation Co-transplantation of rat endothelial progenitor cells to enhance the C Jessup Association Venice, Italy, October 2009 engraftment of pancreatic islets Australian Diabetes Society (ADS) Meeting, Co-transplantation of endothelial progenitor cells to enhance the C Jessup Adelaide, Australia, August 2009 engraftment of pancreatic islets 1st International Conference on Immune Antigen presenting T-cells acquire immunomodulatory properties by R Krishnan Tolerance, Boston, USA, October 2009 contact dependent membrane fragment transfer from genetically modified dendritic cells expressing HLA-G Transplantation Society of Australia and New Generation of tolerogenic dendritic cells by the ectopic expression of R Krishnan Zealand Meeting, Canberra, Australia, the transcription factor FoxP3 in dendritic cells June 2009 Transplantation Society of Australia and New Comparative structural and phonotypical characterisation of new D Mohanasundaram Zealand Meeting, Canberra, Australia, world primate and human pancreatic islets June 2009 International Pancreas and Islet Common Marmoset monkeys – A new world primate model for D Mohanasundaram Transplantation Association Venice, Italy, diabetic research – a comparison with human pancreatic islets October 2009 Annual Australian islet study group Melbourne, A comparative study of Zinc and glucose transporters of marmoset D Mohanasundaram Australia, November 2009 and human islets Transplantation Society of Australia and New Invited Plenary Lecture: Organ donation in Australia S McDonald Zealand Meeting, Canberra, Australia, June 2009 Transplantation Society of Australia and New Living kidney donation from indigenous Australians of the Northern N Rogers Zealand Meeting, Canberra, Australia, Territory, a poor outcome for both donor and recipient June 2009 Transplantation Society of Australia and New Parameters of operational tolerance following adult living donor renal N Rogers Zealand Meeting, Canberra, Australia, transplantation June 2009 generates clinically D Rojas ץ-Australian and New Zealand Society of ‘Fast-DC’ protocol in combination with interferon Nephrology, Hobart, Australia, applicable tolerogenic dendritic cells (TOL-DC) September 2009 International Pancreas and International Rapid generation of tolerogenic dendritic cells (TOL-DC) for D Rojas Pancreas and Islet Transplantation immunomodulation in clinical islet transplantation Association Venice, Italy, October 2009
TQEHresearch Research Report 2009 99 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME International Pancreas and Islet Adenoviral mediated expression of the immunomodulatory molecule D Rojas Transplantation Association Venice, Italy, PD-L2 in human islets maintains stable in vitro islet function October 2009 Australian and New Zealand Society of Kidney Replacement Therapies are Associated with Increased Rates of S Sen Nephrology, Hobart, Australia, Hospital Separation and Mortality for Acute Cardiac Events September 2009 Australian and New Zealand Society Of In vitro Endothelial Cell Tube-Forming Capacity Reduced By Transplant S Sen Nephrology, Hobart, Australia, Sera, but Migration Increased by Haemodialysis September 2009 Transplantation Society of Australia and New A Novel Protocol for the Expansion of CD133+ Human Endothelial S Sen Zealand Meeting, Canberra, Australia, Progenitor Cells in EGM-2 Plus Cytokines June 2009 Transplantation Society of Australia and New Renal Transplantation Decreases Rates of Hospital Separation for Both S Sen Zealand Meeting, Canberra, Australia, Acute Cardiac Events and Cardiac Failure Compared to Dialysis June 2009 Australian and New Zealand Society of Bone parameter monitoring pre- and post-renal R Yu Nephrology, Hobart, Australia, transplantation September 2009
RESPIRATORY MEDICINE UNIT 9th Annual Adverse Events Management In whose interest are we managing this incident? B Smith Conference, Melbourne, Australia, April 2009 TSANZ: ASM: Darwin, Australia, Closing the Gap between Evidence & Practice B Smith March 2009 Australian Practice Nurses Association Practice Performing & Interpreting Spirometry B Smith, D Keatley Nurse Education Conference, Adelaide, Australia, September 2009
RHEUMATOLOGY UNIT ACR/ARHP Annual Scientific Meeting, Philadel- Rheumatology Telemedicine in Rural Australia (poster presentation) S Burnet, T Kelly, phia, USA, October 2009 A Marrinan, P Donohoe, T Wade 10th International Symposium on Sjögren’s Genes associated with Systemic Lupus Erythematosus (SLE) that are B Cobb, F Yiping, syndrome, Brest, France, October 2009 shared with Sjögren’s Syndrome (SS) (poster presentation) R Jonsson, A Bolstad, J Brun, M Rischmueller, S Lester, T Witte, G Illei, M Brennan, S Bowman, K Moser, J Harley, A Sawalha 10th International Symposium on Sjögren’s Possible association of Sjögren’s Syndrome (SS) with THRB, the thyroid B Cobb, F Yiping, syndrome, Brest, France, October 2009 hormone receptor, beta (poster presentation) R Jonsson, A Bolstad, J Brun, M Rischmueller, S Lester, T Witte, G Illei, M Brennan, S Bowman, K Moser, J Harley, A Sawalha 10th International Symposium on Sjögren’s Candidate genes for Sjögren’s syndrome (SS) susceptibility can be B Cobb, F Yiping, syndrome, Brest, France, October 2009 identified by genome wide scans (GWAS) with pooled DNA (oral R Jonsson, A Bolstad, presentation) J Brun, M Rischmueller, S Lester, T Witte, G Illei, M Brennan, S Bowman, K Moser, J Harley, A Sawalha ARA & NZRA in conjunction with RHPA Risk of cancer in patients with biopsy-proven giant cell arteritis: a C Hill, A Cole, (Australia) & NZHPR Combined population-based cohort study (oral presentation) M Rischmueller, Conference, Wellington, NZ, May 2009 T Dodd, M Coleman, G Tucker ARA & NZRA in conjunction with RHPA Effect of socio-economic status (SES) and musculoskeletal pain in C Hill, T Gill, (Australia) & NZHPR Combined Australia (poster presentation) E Shanahan, Conference, Wellington, NZ, May 2009 R Adams, A Taylor ARA & NZRA in conjunction with RHPA Steroid-sparing drug treatments for giant cell arteritis: a systematic C Hill, A Cole, (Australia) & NZHPR Combined Conference, review (poster presentation) S Lester, S Whittle Wellington, NZ, May 2009 ARA & NZRA in conjunction with RHPA Survival in Scleroderma (oral presentation) P Hissaria, S Lester, (Australia) & NZHPR Combined Conference, C Hill, M Ahern, Wellington, NZ, May 2009 M Smith, J Walker, P Roberts-Thomson
TQEHresearch Research Report 2009 100 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME Australian Rheumatology Association (SA TNF inhibitors and risk of serious infection in Rheumatoid Arthritis V Katikireddi, Branch) Annual Scientific and Clinical Meeting, (oral presentation) S Whittle, C Hill Adelaide, Australia, Nov 2009 ARA & NZRA in conjunction with RHPA Functional polymorphisms of the P2X7 gene influence susceptibility S Lester, K Skarratt, (Australia) & NZHPR Combined to Ro/La autoantibody-positive primary Sjögren’s syndromes (oral B Gu, S Downie-Doyle, Conference, Wellington, NZ, May 2009 presentation) J Wiley, M Rischmueller ARA & NZRA in conjunction with RHPA The HLA and autoantibody associations of a large cohort of patients V Limaye, S Lester, (Australia) & NZHPR Combined with biopsy proven idiopathic inflammatory myosisits S Cox, P Bardy, Conference, Wellington, NZ, May 2009 (oral presentation) F Roberts-Thomson ARA & NZRA in conjunction with RHPA An analysis of the Bohan and Peter criteria among patients with biopsy V Limaye, S Lester, S Cox, (Australia) & NZHPR Combined Conference, proven inflammatory myositis (oral presentation) P Roberts-Thomson, Wellington, NZ, May 2009 P Blumbergs Australian Rheumatology Association (SA Normative Hand Grip Strength; The North West Adelaide Health Study N Massey-Westropp, Branch) Annual Scientific and Clinical Meeting, (oral presentation) T Gill, A Taylor, C Hill Adelaide, Australia, November 2009 Australian Rheumatology Association (SA Suprascapular nerve block – is it safe and what do patients think of it? E Shanahan, K Shanahan, Branch) Annual Scientific and Clinical Meeting, (oral presentation) C Hill Adelaide, Australia, November 2009 ARA & NZRA in conjunction with RHPA Screening for pulmonary hypertension and interstitial lung disease in W Stevens, (Australia) & NZHPR Combined systemic sclerosis using the Australian Scleroderma Screening Program J Zochling, M Chan, Conference, Wellington, NZ, May 2009 (ASSP) Database (poster presentation) K Tymms, E Gabbay, J Sahhar, A Sturgess, C Hill, P Youssef, P Nash, S Proudman The Thoracic Society of Australia & New Assessment of cardiopulmonary complications of systemic sclerosis W Stevens, J Byron, Zealand and the Australian & New Zealand using the Australian Scleroderma Screening Program (ASS) Database F Kermeen, J Zochling, Society of Respiratory Science, Annual Scientific K Tymms, E Gabbay, Meetings, Darwin, Australia, April 2009 A Sturgess, C Hill, P Youssef, P Nash, J Sahhar, J Roddy, S Proudman on behalf of ASIG ARA & NZRA in conjunction with RHPA DAS28 and active foot synovitis: Does DAS28 underestimate disease M Wechalekar, (Australia) & NZHPR Combined activity in rheumatoid arthritis? (oral presentation) S Lester, S Proudman, Conference, Wellington, NZ, May 2009 L Cleland, S Whittle, M Rischmueller, C Hill ARA & NZRA in conjunction with RHPA Lex Parsimoniae vs Lateral Thinking (oral presentation) M Wechalekar (Australia) & NZHPR Combined Conference, Wellington, NZ, May 2009 Australian Rheumatology Association (SA Comparison of DAS28 derived from ESR or CRP in patients with M Wechalekar, E Ang, Branch) Annual Scientific and Clinical Meeting, Rheumatoid Arthritis (oral presentation) S Lester, S Burnet, Adelaide, Australia, November 2009 M Rischmueller, S Whittle, L Cleland, S Proudman, C Hill ARA & NZRA in conjunction with RHPA Steroid-sparing drug treatments for polymyalgia rheumatica: a system- S Whittle, A Cole, (Australia) & NZHPR Combined atic review (poster presentation) S Lester, C Hill Conference, Wellington, NZ, May 2009
SURGERY, University of Adelaide Discipline of European Society for Vascular Surgery Annual Should we develop a core International Curriculum for Vascular and R Fitridge, F Quigley, Scientific Meeting, Norway, September 2009 Endovascular Surgery? M Vicaretti General Surgeons Australia Trainees Day, Assessment and Principles of Management of the Diabetic Foot R Fitridge Brisbane, Australia, May 2009 Lyell McEwin Health Service Diabetes Day, Overview of Assessment and Management of the Diabetic Foot R Fitridge Adelaide, Australia, November 2009 Management of the High Risk Diabetic Foot The Diabetic Foot in Australasia R Fitridge (Workshop), Alice Springs, Australia, May 2009 Management of the High Risk Diabetic Foot Clinical and Vascular Assessment of the Diabetic Foot R Fitridge (Workshop), Alice Springs, Australia, May 2009 Management of the High Risk Diabetic Foot Overview of Managing the Diabetic Foot R Fitridge, M Hamilton, (Workshop), Alice Springs, Australia, May 2009 S Jones Management of the High Risk Diabetic Foot Revascularisation of the Diabetic Foot R Fitridge, M Hamilton (Workshop), Alice Springs, Australia, May 2009 Provincial Surgeons of Australia Annual The Diabetic Foot in Australasia R Fitridge Scientific Conference, Alice Springs, Australia, July 2009 Provincial Surgeons of Australia Annual Calf Vein Thrombosis R Fitridge, S McRae, Scientific Conference, Alice Springs, Australia, N Blest July 2009
TQEHresearch Research Report 2009 101 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME Provincial Surgeons of Australia Annual Perioperative Management of Anticoagulants and Anti-platelet Agents R Fitridge, S McRae, Scientific Conference, Alice Springs, Australia, C Gibb, K Galuszka July 2009 Provincial Surgeons of Australia Annual Vascular Assessment of the Diabetic Foot R Fitridge Scientific Conference, Alice Springs, Australia, July 2009 Provincial Surgeons of Australia Annual Revascularisation of the Diabetic Foot R Fitridge, Scientific Conference, Alice Springs, Australia, M Hamilton July 2009 Royal Australian College of Surgeons Annual A multi-centre trial to assess the ERA model: Predicting outcomes after R Fitridge Scientific Congress, Brisbane, Australia, May EVAR 2009 Royal Australian College of Surgeons Annual How do we train the future Vascular Specialist? R Fitridge Scientific Congress, Brisbane, Australia, May 2009 European Society of Cataract and Refractive Managing astigmatism with toric implants and LRIs in cataract and M Goggin Surgeons Annual Congress, Barcelona, Spain, refractive surgery: didactic course September 2009 The 24th Congress of the Asia-Pacific Academy Reproducibility in keratometry M Goggin of Ophthalmology, Bali, May 2009 Annual Paediatric Surgical Update, Women’s Masters Degree in Minimally Invasive Surgery P Hewett and Children’s Hospital, Adelaide, Australia, October 2009 International Surgical Week, Adelaide, How to mobilize the splenic flexure laparoscopically P Hewett Australia, September 2009 HTAi Policy Forum 2009 San Francisco, USA, HTA for optimization of technology utilization. What is optimal use of G Maddern February 2009 technology: the clinician’s experience International meeting for HTA-emerging Health technology assessment: the Australian experience G Maddern countries, Ankara, Turkey, March 2009 International meeting for HTA-emerging Governance and health technology assessment G Maddern countries, Ankara, Turkey, March 2009 International meeting for HTA-emerging Coordinating HTA practices worldwide G Maddern countries, Ankara, Turkey, March 2009 Health Technology Assessment Principles and Introduction to evidence based health care and HTA G Maddern Practices, Kuching, Malaysia, April 2009 Health Technology Assessment Principles and Generalising and transferability of HTA G Maddern Practices, Kuching, Malaysia, April 2009 Health Technology Assessment Principles and Knowledge transfer: challenges in putting HTA into practice G Maddern Practices, Kuching, Malaysia, April 2009 Health Technology Assessment Principles and Health technology assessment in hospital and district general hospital G Maddern Practices, Kuching, Malaysia, April 2009 settings Health Technology Assessment Principles and Model of implementation of HTA activities: the Australian experience G Maddern Practices, Kuching, Malaysia, April 2009 Health Technology Assessment Principles and Meeting decision makers’ needs G Maddern Practices, Kuching, Malaysia, April 2009 Serdang Hospital, Malaysia, April 2009 How to present your work at a meeting and how to get your G Maddern paper published Basil Hetzel Institute for Medical Research Development and assessment of novel surgical technologies and their G Maddern Seminar Series, The Queen Elizabeth Hospital, introduction into the Australian healthcare system April 2009 South Australian Nurse Practitioners Group, Medical workforce solution: Delegation or substitution? G Maddern June 2009 Medtronic Symposium, 6th Annual Meeting Rapid HTA – Inventory of current methods and practice around G Maddern HTAi, Suntec Convention Centre, Singapore, the globe. June 2009 Plenary Session, 6th Annual Meeting HTAi, Coordination of HTA activities among established HTA agencies and G Maddern Suntec Convention Centre, Singapore, programs June 2009
Medical Insurance Group Australia, Adelaide- Hypothetical: Treating adolescents – A challenge in confidentiality and G Maddern 1 August, Sydney-22 August, Melbourne-12 consent September, Barossa Valley-10 October 2009, Adelaide-21 November, Coonawarra-28 November 2009 International Surgical Week, Adelaide, Stage 4 colon cancer: How much liver resection is too much? G Maddern Australia, September 2009
TQEHresearch Research Report 2009 102 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME 33rd Annual Australasian Society of Aesthetic Audit and clinical governance satisfying the RACS CPD requirements in G Maddern Plastic Surgery Conference 2009 Sydney, private practice Australia, October 2009 The Australian Council of Healthcare Hypothetical: Working with consumers (Facilitator) G Maddern Standards, Ballarat-5 October, Adelaide- 7 October, Sydney-2 November, Gold Coast, Australia, 9 November 2009 The Australian Council of Healthcare Hypothetical: Multidisciplinary teamwork for Safety (Facilitator) G Maddern Standards, Ballarat-5 October, Adelaide- 7 October, Sydney-2 November, Gold Coast Australia, 9 November 2009 Surgical innovation: Issues around evaluation, The Australian solution G Maddern education, accreditation and reimbursement American College of Surgeons 95th Annual Clinical Congress, Chicago, Illinois, USA, October 2009 Macquarie University, Sydney, Australia, Hypothetical: The cutting edge of innovative treatments: the hazards G Maddern November 2009 of progress (Panel Member) Chinese colorectal society meeting, China, Single incision laparoscopic assisted colectomy N Rieger February 2009 ASCO 2009 Gastrointestinal Cancers Impact of the national bowel cancer screening program in Australia N Rieger, S Ananda, Symposium, San Francisco, USA, 2009 (NBCSP) utilising faecal occult blood test (FOBT) screening on the S McLaughlin, F Chen, diagnosis of colorectal cancer I Hayes, A Hunter, I Skinner, M Steel, I Jones, PF Gibbs Advanced trainee gastroenterology day, A surgeon’s approach to rectal cancer N Rieger Repatriation General Hospital, Adelaide, Australia, June 2009 Continence in the Country Symposium, Berri Faecal incontinence N Rieger Hospital, Australia, August 2009 International Surgical Week, Adelaide, Single incision laparoscopic (SIL) assisted right colectomy using N Rieger Australia, September 2009 standard laparoscopic instrumentation. (Video Presentation) Adelaide prostate cancer support group, The bowel and prostate cancer N Rieger Adelaide, Australia, September 2009 Calvary Hospital Nurse Education evening, SILS / NOTES/ Bowel preparation N Rieger Adelaide, Australia, October 2009 Continence Foundation of Australia 18th Perineal Workshop - Anatomy, Disruption and Outcomes Post N Rieger National Conference on Incontinence, Childbirth Adelaide, Australia, November 2009 British Society of Gastroenterology Annual Barrier breakdown in ulcerative colitis: the case of nitrosothiols WEW Roediger, General Meeting, Glasgow, Scotland, impairing colonocytes AG Cummins, March 2009 P Cowled From Menace to Marvel” Nitric oxide in Health Nitric oxide in intestinal barrier breakdown WEW Roediger and Disease”, University of Hertfordshire, The Biopark, Welwyn Garden City, United Kingdom, March 2009 John Radcliffe Hospital, Gastroenterology Unit, Crohn’s disease as an infection WEW Roediger Oxford, UK, March 2009 General Surgeons Australia (GSA) Trainee’s Demystifying the FRACS Part II Exam D Walsh Day, Adelaide, Australia, September 2009 International Association of Endocrine Chair: Endocrine surgery update D Walsh Surgeons postgraduate Meeting, Adelaide, Australia, September 2009 International Surgical Week 2009, Adelaide, Chair: Tailor-made breast surgery D Walsh Australia, September 2009 SA Breast Endocrine Surgical Journal Club, Highlights from the ANZBCTG meeting 2009 D Walsh Adelaide, Australia, Sept 2009
SA Familial Cancer Genetics Service and Prophylactic surgery for BRCA carriers D Walsh Women’s and Children’s Hospital, Adelaide, Australia, July 2009 TQEH Postgraduate Nurse Study Day, Adelaide, Targeted therapy in breast cancer D Walsh Australia, July 2009
TQEHresearch Research Report 2009 103 CONFERENCE TITLE & DATE TITLE OF TALK/POSTER ATTENDEE NAME ORTHOPAEDICS AND TRAUMA ANZORS (Aust and NZ Orthopaedic Research A Rationalisation of Outcome Scores for Low Back: the ODI 2.0 and V Eranki, A Fagan Society), Adelaide, Australia, October 2009 the LBOS Sherbrook Orthopaedic Meeting, Quebec, Cognitive Decline Following THR, TKR and Navigated TKR P Lewis Canada, September 2009 Sherbrook Orthopaedic Meeting, Quebec, The Avon Knee P Lewis Canada, September 2009 Sherbrook Orthopaedic Meeting, Quebec, Operative Treatment of Gluteal Tendon Repair P Lewis Canada, September 2009 Sherbrook Orthopaedic Meeting, Quebec, Re-operations after Oxford Uni Replacement P Lewis Canada, September 2009 Australian Orthopaedic Association National Operative Treatment of Gluteal Tendon Repair P Lewis Meeting, Noosa, Australia, May 2009 Australian Orthopaedic Association Abductor Dysfunction after Hip Replacement P Lewis SA Branch, Adelaide, Australia, August 2009 Australian Orthopaedic Association National Abductor Dysfunction after Hip Replacement P Lewis Meeting, Noosa, Australia, May 2009
THERAPEUTICS RESEARCH CENTRE European Pharmaceutical Sciences Meeting: Structure - Transport Relationships MS Roberts Pharmacokinetics: Spearheading advances and delivering the science’ (on the occasion of Professor Malcolm Rowland’s 70th birthday) London, UK, October 2009 University of Bath, UK, October 2009 Skin, the final frontier in drug delivery MS Roberts 12th Annual Force Health Protection Penetration of nanoparticles through human skin? MS Roberts Conference, Albuquerque, New Mexico, USA, August 2009 International Skin Pharmacology Conference, New perspectives in solute structure - skin penetration relationships MS Roberts Boston, USA August 2009 36th Annual Meeting And Exposition Of The Enhancement Strategies in Skin Penetration of Solutes and Nanoparti- MS Roberts Controlled Release Society, Copenhagen, cles: Species Differences Denmark, July 2009 4th Workshop on Advanced Multiphoton and Penetration of nanoengineered systems into human epithelia MS Roberts Fluorescence Lifetime Imaging Techniques FLIM 2009, University of Saarland, Saarbrücken, Germany, June 2009 12th Canadian Society for Pharmaceutical Recent Developments in Transdermal Drug Development MS Roberts Sciences (CSPS) Annual Symposium, Toronto, Canada June 2009 The Australian College of Dermatologists Nanotechnology in suncreens – is it safe? MS Roberts 42nd Annual Scientific Meeting, Gold Coast, Australia, May 2009 Australian Government, Department of Health Introduction to pharmacokinetics: absorption, clearance, volume of MS Roberts and Ageing, Therapeutic Goods Administration distribution, half-life, protein binding, Meeting: Nanotechnology Training Program bioavailability Discovery Centre, CSIRO, Canberra, Australia, May 2009 Australian Government, Department of Health Routes of exposure to Nanoparticles MS Roberts, and Ageing, Therapeutic Goods Administration YTM Wu Meeting: Nanotechnology Training Program Discovery Centre, CSIRO, Canberra, Australia, May 2009
TQEHresearch Research Report 2009 104 Research Support Structures
TQEHresearch Research Report 2009 105 The Basil Hetzel Institute Policy Committee
Established in 1996, the Clinical Development Research training promotion Research Centre, now the Basil Hetzel Institute In 2009 research training opportunities and (BHI) Policy Committee’s role is to provide Scholarship support were actively promoted strategic advice for the running of the BHI and through the hospital’s research Internet site to optimise the available support for research with links to key university research training programs across The Queen Elizabeth Hospital sites. (TQEH). Strategy for 2009 The Committee is comprised of senior The goals of the research support strategy representatives from: were to provide up to: “A continuing • the two universities with whom the • 7 TQEH Research Foundation Postgrad- hospital is affiliated, Adelaide University uate Research Scholarships generous level of and the University of South Australia; • 10 TQEH Research Foundation Honours funding from the • University of Adelaide academic heads Scholarships TQEH Research of departments at TQEH (Medicine and • 8 TQEH Research Foundation Vacation Surgery); Scholarships Foundation has • Allied Health allowed seven • Chair, Strategic Research Directions TQEH Research Foundation Vacation Working Group Research Scholarships continuing higher • BHI Facility Manager and Eight placements offered in TQEH research degree candidates • the scientific community settings over the 2008/2009 vacation were generously funded through the Research to be supported Professor Guy Maddern was reappointed Foundation and provided scholars with in 2009.” to the position of Director of Research in the opportunity to gain valuable research February 2005 for a five-year term. This experience in a clinical/laboratory environ- leadership position has been critical to ment. furthering the aims of research excellence and enhancing the research reputation of TQEH. TQEH Research Foundation Honours Research Scholarships Several sub–committees assist the BHI Policy Honours Scholarships continued to be Committee as required, notably the: offered at TQEH in 2009. Nine Scholarship • Research Day Organising Committee, recipients undertook projects across a range chaired by Dr Prue Cowled, University of Departments including Clinical Pharma- of Adelaide Discipline of Surgery, in the cology, Transplantation-Immunology, planning and running of the annual Surgery, Neurology and Cardiology. Research Day event. Higher Degrees • Scholarship Selection Committee, chaired by Professor Maddern, in awarding a range In 2009 sixty scholars were undertaking of scholarships funded by TQEH Research research towards Higher Degrees at TQEH. Foundation. A continuing generous level of funding • BHI Management Committee, chaired by A/ from the TQEH Research Foundation has Professor Ray Morris, Clinical Pharmacology allowed seven continuing higher degree Unit, in managing the new research facility. candidates to be supported in 2009. While seven TQEH Research Foundation Scholar- TQEH Research Secretariat undertakes a ships were available to support students range of activities to assist the Director of commencing in 2009, only three were Research in supporting, fostering and adminis- awarded as other applicants were successful tering quality research activity across TQEH. in obtaining externally funded Scholarships, Gwenda Graves and Bronwyn Lenton man the (APA, and NHMRC). Secretariat. In 2009 TQEH Research Foundation Scholar- Research Training ships provide for stipends which match the The BHI Policy Committee aims to support Australian Postgraduate Award (APA) rate, the research capacity within basic and clinical as well as a maintenance allowance for each areas through its strategy of providing a student to assist the Department in which number of scholarships at postgraduate, they are undertaking the research work. Honours and vacation levels. From 2010 Scholarships will no longer be TQEHresearch Research Report 2009 106 centrally funded as in the past, but will be tion of the great research ethos of our The Institute Management funded via the TQEH Research Foundation new building! However, because of the Committee (Pictured rear left to right): Program grants (commenced 2009), thereby limited time available for oral presentations, Dr Prue Cowled, Dr Yuliy devolving primary responsibility for selection selection was very competitive and much Chirkov, A/Prof Ray Morris, of research students to research groups. high quality research could not be included Dr Peter Zalewski, in the final oral programme. A number Dr Lor Wai Tan A record number of APA students (4) of researchers chose to present their work (Seated left to right): A/Prof Peter Coyle, commencing research at TQEH in 2009 in poster format and compete for the Ms Sandy Pickering, were awarded TQEH Research Foundation Poster Prize. Dr Andrew Holmes, Top Up Scholarships, valued at $5,000 each. Ms Gwenda Graves Other higher degree students at TQEH have The Plenary Lecture presented by Professor scholarship support from a range of funding David Vaux of La Trobe University was Absent: Dr Petra Neufing, Mr Matthew Smith, bodies, including NHMRC, the University of enthusiastically received. In a most Ms Kathryn Hudson, Adelaide (International scholarships, APA, entertaining manner, Professor Vaux Ms Darling Rojas. and Faculty ‘Divisional’ scholarships) and the challenged our knowledge of data analysis non-profit sector including Kidney Health and statistics, providing a series of “take Australia and Freemasons. home messages” to help interpret data in published papers and to help with prepara- Research Day 2009 tion of manuscripts. All those attending Research Day 2009 was held for the first agreed that they learnt some valuable time in our brand new research building! lessons! Research Day has been held for 15 years now and continues to be recognized as Sponsorship for the Day was obtained a significant annual event in the research from many sources, both University and calendar at TQEH. The long-established corporate. However our major sponsor for purpose of the Day is to provide an Research Day has for many years been The opportunity for students and those “in Queen Elizabeth Hospital Research Founda- training” to practice and develop presenta- tion and we are very grateful for this long tion skills under conditions that are typical term support. This year TQEH Research of most professional society congresses. Foundation sponsored five presentation With this experience, it is expected that prizes and we look forward to the Founda- research quality from TQEH will benefit as tion’s continued support. The Day was our researchers deliver their work to national or most successful yet, and our winners are international congresses. Prizes are awarded identified in the Award section of the report. in a number of categories for the best presentation and competition is fierce! Dr Prue Cowled, This year, the Committee was delighted Chair, Research Day Organising to receive a record 42 Abstracts, a reflec- Committee, 2009
TQEHresearch Research Report 2009 107 “The service is well Statistical Support Service, TQEH Staff The Statistical Support Service, jointly JBF Field BSc(Hons) PhD AStat used by staff and funded through the Basil Hetzel Institute students, with and the Faculty of Health Sciences at the 2009 Papers published with over 50 reports University of Adelaide, provides 10 hours J Field as co author: per week statistical consultancy to staff Chapman IM, Visvanathan R, Hammond being produced and students at the BHI and TQEH more AJ, Morley JE, Field JBF, Tai K, Belobra- during the year, generally. jdic DP, Chen RYT, Horowitz M. Effect of testosterone and a nutritional supplement, plus many The service is well used by staff and alone and in combination of hospital other shorter students, with over 50 reports being admissions in undernourished older men consultations produced during the year, plus many and women. Amer J Clin Nutr. 2009; other shorter consultations requiring lesser 89:880-9. requiring lesser assistance. assistance.” Beule A, Athanasiadis T, Athanasiadis E, The range of services has included Field J, Wormald PJ. Efficacy of different • Assisting with the design of health- techniques of sinonasal irrigation after related research; modified Lothrop procedure. Am J Rhinol • Power and sample size calculations; Allergy. 2009 Jan-Feb; 23(1):85-90. • Advising research staff and students on statistical aspects of research programs; Thwin M, Weitzel E, McMains KC, Athana- • Providing advice about cleaning and siadis T, Psaltis A, Field J, Wormald PJ. maintaining datasets and preparing data Validating the use of report-derived for analysis; Lund-McKay scores Am J Rhinol Allergy. • Providing advice about data analysis and 2009 Jan-Feb; 23(1):33-5. manuscript preparation; • Undertaking analysis of data as part of Smith ML, Bain Gregory I, Chabrel N, research projects and programs. Turner P, Carter C, Field J. Using computed tomography to assist with diagnosis of avascular necrosis complicating chronic scaphoid nonunion. J Hand Surgery. 2009;34(6):1037-43.
McLean JM, Turner PC, Bain GI, N Rezaian, Field JBF, Fogg Q: An association between lunate morphology and scaphoid- trapezium-trapezoid arthritis. J Hand Surgery. (European Volume) 2009, 34E: 778-782.
Jervis-Bardy J, Foreman A, Field J, Wormald PJ. Impaired mucosa healing and infection associated with S.aureus following endoscopic sinus surgery. Am J Rhinol. Allergy. 2009 Sep-Oct; 23(5):549-52.
Jones TE, Victor PJ, Peisach AR, Field J. Aminoglycoside clearance is a good estimate of creatinine clearance in intensive care unit patients. Anaesthesia and Intensive Care. 37(6), 944-952.
TQEHresearch Research Report 2009 108 Basil Hetzel Institute (BHI) Policy Committee
Current Members, December 2009 Prof Guy Maddern Prof Richard Ruffin Prof Justin Beilby (proxy - Prof Andrew Somogyi) Mrs Jackie Wood Prof Pat Buckley Ms Diana Brown Dr Jenny Kennedy Dr Prue Cowled Dr Ravi Krishnan A/Prof Richard D’Andrea A/Prof Ray Morris Mr Paul Flynn Ms Kathryn Hudson A/Prof Simon Koblar
Ex-officio A/Prof Robert Adams
Executive Support Ms Gwenda Graves
Basil Hetzel Management Committee Current members, December 2009 The Institute Level Representative Ground Level Mrs Sandy Pickering Level 1 Dr Prue Cowled Dr Lor Wai Tan Dr Petra Neufing Level 2 Dr Peter Zalewski Dr Yuliy Chirkov Dr Andrew Holmes Surgical Suite Mr Matthew Smith Hanson Institute A/Prof Peter Coyle Postgraduate Ms Darling Rojas Chair A/Prof Ray Morris Facility Manager Ms Kathryn Hudson
Executive Support Ms Gwenda Graves
TQEHresearch Research Report 2009 109 Facility Manager Reflections
When reflecting on all that has been The Institute Management Committee achieved in the past year, it is easy to has overseen and provided advice on become daunted by the sheer volume of the donation of over $730,000 worth of work and changes implemented in 2009. equipment by TQEH Research Foundation It has indeed been a very busy year for since moving into our new building. This researchers at The Queen Elizabeth Hospital, equipment has significantly upgraded our and there have been many exciting develop- basic laboratory infrastructure, but also ments which all correspond to make the provided some key pieces which increase Basil Hetzel Institute(BHI) a stimulating and our research capabilities, including a dynamic place to work and study. laser capture dissection microscope and Bioplex suspension array system. This large It has been fascinating to witness just how donation of equipment is in addition to the much the change in physical space has student support provided by the Research impacted positively on researcher relation- Foundation, and the significant funding via ships, collaborations and built a strong the Program Grants previously mentioned. sense of community. Also contributing The BHI researchers are extremely grateful Kathryn Hudson, to this cross disciplinary and collaborative for the continued support of the TQEH BHI Facility Manager feel is the significant funding provided by Research Foundation. the TQEH Research Foundation Program “It has been Grants. This major funding has seen the 2009 has also seen the expansion of the fascinating to reinforcing of several established collabo- Renal research group to the RAH, which rations, and the development of new is an exciting opportunity for them. It witness just how collaborations. Importantly this funding has is perhaps too soon to fully appreciate much the change in supported employment of new post doctoral just how this will affect the Institute and researchers, which has strengthened the early occupants, however, I am confident that the physical space has and mid career cohort at the BHI, which in flexibility of space and our personnel will impacted positively turn will lead to a stronger mentoring and see opportunities for current BHI groups to on researcher knowledge base for our students. The post expand and the attraction of new research doctoral researchers, led by Dr Claire Jessup, groups to The Institute. relationships, have created an “Early Career Researcher collaborations and group” and have held monthly informative Of course a move such as we have just and engaging seminars and discussion panels undertaken has provided a number of built a strong sense on topics ranging from career opportunities challenges for staff and students, both of community.” and advice, grant and fellowship writing tips adjusting to the new physical space and to journal clubs sessions. also building interpersonal and interdepart- mental relationships. As expected, change Operationally, the BHI Management management is always an emotional and Committee has a number of new initiatives testing time for some, with huge leaps which are designed to keep The Institute forward and some steps backward. The building flexible and space functionally new physical space, focus on collabora- defined. We are building on a “facility tive research and community approach to approach” to provision of infrastructure and major decisions leaves us on a very solid equipment and continue to build the sense foundation for research success in 2010. of community between researchers. I have We continue to build upon that which has been working towards creating a number already been achieved, and I will continue of centralised Institute resources, including to facilitate on behalf of the Management a centralised cryogenic store and a research Committee and researchers to create a purchasing store. The cryogenic store was productive, efficient and innovative research made possible by a significant donation of environment. the large tank and associated equipment by Professor Basil Hetzel. The creation of Kathryn Hudson the centralised cryogenic store has greatly Facility Manager reduced our personnel hours, reduced our The Institute (BHI) ongoing costs and dramatically increased the stability of our long term samples.
TQEHresearch Research Report 2009 110 2009 Awards
TQEHresearch Research Report 2009 111 Awards Research Day 2009 Award Winners
Research Day Award Winners. (Pictured rear left to right): Dr Andrew Foreman, Mr Raymond Yu, Dr Shaundeep Sen, Dr Michael Collins (Front left to right): Ms Darling Rojas, Ms Nicole Such, Ms Kanchani Rajopadhyaya
Honours Students, Basic Science “Calcium Supplementation and its Effects on Bone Loss Raymond Yu, Renal Unit TQEH. in Renal Transplant Recipients” Supervisor: A/Prof PTH Coates. (Prize sponsored by TQEH Research Foundation)
Junior Laboratory PhD students “Endothelin-1-Mediated Vasoconstriction involves rapid and sustained Kanchani Rajopadhyaya, Cardiology protein Kinase C and rho Kinase activation” Unit, TQEH. Supervisors: (Prize sponsored by TQEH Research Foundation) A/Prof JF Beltrame, Dr DP Wilson.
Senior Laboratory PhD students “Rapid generation of Clinically Applicable Tolerogenic Dendritic Cells: Darling Rojas, Renal Unit, TQEH. a Potential Cellular Therapy for Transplant Rejection” Supervisors: A/Prof PTH Coates. (Prize sponsored by TQEH Research Foundation) Dr R Krishnan,
Higher Degrees Clinical & Registrars “Do S. Aureus Biofilms contribute to CRS Pathogenesis?” Andrew Foreman, Otolaryngology, (Prize sponsored by TQEH Research Foundation) Head and Neck Surgery, TQEH. Supervisors: Prof PJ Wormald, Dr LW Tan.
Allied Health – Pharmacy “Assessment of the Suitability of Surgical Discharge Medications; Are we Nicole Such, Pharmacy Dept, TQEH. getting it right?” Supervisor: Ms S Goldsworthy. (Prize sponsored by University of South Australia)
Poster Prize “Renal Transplantation Decreases rates of Hospital Separation for Acute Shaundeep Sen, Renal Unit, TQEH. Cardiac Events but not Cardiac Failure Compared to Dialysis”. Supervisors: A/Prof SP McDonald, (Prize sponsored by TQEH Research Foundation) A/Prof PTH Coates, A/Prof JF Beltrame
Best Lay Description “Screening for Colorectal Cancer in Recipients of Kidney Transplants” Michael G Collins, Renal Unit, TQEH. (Prize sponsored by TQEH Research Foundation) Supervisor: A/Prof PTH Coates, Dr S Alexander.
TQEHresearch Research Report 2009 112 Other 2009 Award Winners
Prof PJ Wormald A/Prof Renuka Visvanathan Dr Shaundeep Sen
Haematology-Oncology Robinson K SA Health Award 2009: on behalf of the SA BloodSafe Program.
Medicine Visvanathan R Awarded Lundbeck Fellowship by Australia and New Zealand Society for Geriatric Medicine
Neurology Leong WK University of Adelaide School of Molecular and Biomedical Science, 1st prize Open Science Category
Otolaryngology, Head and Neck Surgery Foreman A Australian Society of Otolaryngology Head and Neck Surgery, Ronald Gristwood Medal for Best Registrar Presentation Valentine R American Rhinologic Society Maurice Cottle Award, Best Scientific Presentation Wormald PJ American Rhinologic Society Golden Head Mirror Award for Significant Contribution and Teaching in ENT Renal Department Carroll R Mark Cock’s Award from the TSANZ and TeamLife Transplant Australia Hughes A TSANZ Young Investigator Award Rao MM Member of the Order of Australia – Queen’s Birthday Honour. For service to medicine, particularly renal transplant surgery, as a mentor and educator, and through professional development Rao MM ‘Lifetime Achievement Award’ by the Indian Society of Organ Transplantation in recognition of his role for pioneering transplantation in India
Rojas D ANZSN Young Investigator Finalist $500
Sen S Kidney Health Australia Prize for the Best Presentation in the Field of Clinical Research Sen S TSANZ Young Investigator Award
TQEHresearch Research Report 2009 113 Mohan Rao Receives Order Of Australia Award
Associate Professor Mohan Rao, a renal difficult operations. When my colleagues transplant surgeon at TQEH was appointed in transplant surgery, who were sceptical as a Member of the Order of Australia (AM) when we introduced laparoscopic donor in the 2009 Queen’s Birthday Honours list nephrectomy at TQEH, asked for my help in for service to medicine (particularly renal establishing it in their units and when I was transplant surgery), as a mentor named an Angel by Kidney Health Australia and educator and through professional in 2006.’ development. In 2009, Mohan was also awarded a The award was announced by the Governor- ‘Lifetime Achievement Award’ by the Indian Associate Professor General of Australia with an investiture Society of Organ Transplantation in recogni- Mohan Rao ceremony held at Government House in tion of his role for pioneering transplanta- September 2009. tion in India.
Mohan came to TQEH from India in 1968 Mohan has taken long service leave prior to train as the first registrar in transplant to his retirement and will not be moving surgery under the watchful eye of Mr Peter with TQEH Renal Unit to the Royal Adelaide Knight, who performed the first successful Hospital in January 2010. He wanted to kidney transplant in Australia in March finish his career as a transplant surgeon at 1965. TQEH, where it all started.
Apart from a five year hiatus from Mohan has been appointed as a visiting 1971-1976, when he returned to India Professor to a Malaysian University in Kuala and performed the first successful renal Lumpur, where he is establishing a kidney transplant in that country and helped to transplant program and training surgeons in establish transplant units, Mohan’s career this field. has spanned over 40 years with the Renal Unit at TQEH.
‘My return to Adelaide in 1976 was because I enjoyed and benefited from my first stay in 1968, which was initiated by Professor Basil Hetzel who, at the time, was Professor of Medicine at TQEH. I chose coming to TQEH in preference to accepting a senior commonwealth Fellowship at Oxford in England.’
‘Christian Medical College in Vellore, India made me a doctor and a surgeon - TQEH made me a renal transplant surgeon. I have worked all my life in these two institutions and I am satisfied that I have made signifi- (Pictured left to right): Dr Alex Disney, cant contributions at both places.’ Prof Mohan Rao, Prof Graeme Russ
Mohan says one of his most memorable achievements in his career at TQEH was introducing the laparoscopic method of live donor nephrectomy to Australia and popularising this method which has now become the standard in almost all renal units.
‘There have also been a lot of rewarding moments at TQEH – all the successful transplants, especially the technically
TQEHresearch Research Report 2009 114 Mohan Rao Receives Order Of Australia Award Acknowledgements
The Queen Elizabeth Hospital gratefully acknowledges and thanks the following organisations for their support to medical, scientific, nursing and allied health research:
Adelaide Integrated Biosciences(AIB) Laboratories Kidney Health Australia Adelaide Microscopy Leukaemia and Lymphoma Society of USA Alzheimer’s Australia Merck Sorono Pharma Anne Marie Trimboli Trust Monash University Arthritis Australia Muriel T Gunn Foundation ASERNIPS National Breast Cancer Centre Australia & New Zealand Intensive Care Research Centre National Health & Medical Research Council (NHMRC) Australian National University National Heart Foundation of Australia Australian Neurology National Stroke Foundation Australian Red Cross Blood Service (ARCBS) Nepean Hospital Australian Research Council (ARC) Osteoporosis Australia Baker Heart Research Institute Pfizer Australia (CVL) BioInnovation SA Peter MacCallum Institute Boehringer Ingelheim Rebecca L Cooper Foundation Biomet Royal Adelaide Hospital Cancer Australia Royal Australian College of General Practitioners Cancer Council of South Australia Royal Australasian College of Surgeons Catholic Archdiocese of Sydney Sanofi CellCept Australia South Australian Department of Health Centre for Genomic Sciences Stroke SA Channel 7 Children’s Medical Research Foundation of SA Stryker Child Health Research Institute St Jude’s Research Institute, Memphis USA Child, Youth & Women’s Health Service – Familial Cancer Unit St Vincent’s Institute Melbourne Clive and Vera Ramaciotti Foundation Surgical Synergies Commonwealth Dept of Health & Aged Care The Mason Foundation Divisions of General Practice The Northern Communities Health Foundation Inc Flinders University The Queen Elizabeth Hospital Research Foundation Garnett Passe and Rodney Williams Memorial Foundation Trevor Prescott/Freemasons Society Haemophilia Foundation Women’s and Children’s Hospital Hanson Institute University of Adelaide Inner Wheel Australia University of Columbia Institute of Medical & Veterinary Science (IMVS) University of Queensland – Diamantina Institute Intensive Care Foundation University of South Australia John T Reid Charitable Trusts Walter & Eliza Hall Institute Juvenile Diabetes Research Foundation Women’s and Children’s Hospital Adelaide
TQEHresearch Research Report 2009 115 The Queen Elizabeth Hospital Research Foundation
TQEHresearch Research Report 2009 116 The Queen Elizabeth Hospital Research Foundation
The Queen Elizabeth Hospital Research BOARD DETAILS Foundation (TQEHRF) has been benefiting the South Australian community for 44 Chair years through dedicated support of world- Ms Lee Jameson – Mr Ken Milne – class medical and health research at The Managing Director, Architect, Milne Architects Pty Ltd. Queen Elizabeth Hospital (TQEH). Gray Management Group Professor Richard Ruffin – Over the past 16 years, TQEHRF has Deputy Chair Director, Division of Medicine, provided more than $15 million to research Mr John MacPhail – The Queen Elizabeth Hospital. at TQEH. Your support of TQEHRF has been Partner, Finlaysons vital to the ongoing work at The Queen Mrs Melinda OLeary – Elizabeth Hospital’s research facility, The Board members Nova Aerospace Australia Institute, including the Basil Hetzel Institute, Associate Professor John Beltrame enabling the researchers to conduct – Cardiologist, The Queen Elizabeth Ms Luciana Larkin – valuable work in the fields of cancer Hospital / Associate Professor of Partner, Tregloans Chartered research, heart and kidney disease, diabetes, Medicine Accountants asthma and other serious conditions. Mr John Hender – Mr Paul Flynn – The research staff and students at The State Manager – SA, Private Wealth CEO, The Queen Elizabeth Queen Elizabeth Hospital and The Institute – Private Clients, Perpetual Pty Ltd. Hospital Research Foundation rely heavily on TQEHRF to ensure they can maintain a reputation for quality ‘bench to beside’ research, where laboratory findings are quickly translated into numerous patient care and treatment options.
Ms Lee Jameson Mr John MacPhail A/Prof John Beltrame Mr John Hender
Mr Ken Milne Prof Richard Ruffin Mrs Melinda O’Leary Mr Paul Flynn
TQEHresearch Research Report 2009 117 Chair’s Report I am honoured to be presenting my first tickets prior to the early bird deadline. Chair report for The Queen Elizabeth It is without question the calibre of prizes on Hospital Research Foundation, and it is with offer and the exposure the lottery achieves a great deal of pride that I am able to report state-wide that increases the awareness of The a record year for the Foundation, delivering Queen Elizabeth Hospital Research Foundation just under $2 million in funds towards as a whole, and it is this exposure that assists medical research, an increase of twenty five the Foundation’s other initiatives. percent on last year’s results. Our Planned Giving is growing a very strong These fabulous results come from much base, as is the Basil Hetzel Society with over hard work, dedication and great passion 250 donors making a commitment to support Ms Lee Jameson, Chair undertaken by the staff, volunteers and world-class medical research. supporters of The Queen Elizabeth Hospital Research Foundation. The Foundation would The Research Foundation Tribute Funds are not be in the position it is today without continuing to grow as does our In Memoriam “The Institute is a the leadership and dedication shown by our Gifts, all of which would not be possible outgoing Chairman and Deputy Chairman, without the support of our staff and volunteers. physical reminder of Mr John Michell and Mr Ray McGrath. why TQEHRF exists The Research Foundation is known for being – providing funds To honour the unwavering commitment and entrepreneurial in its manner of fundraising. support shown, the board are pleased to Our Black Tie Event, this year titled “An to assist medical announce a “John Michell Early Career Fellow- Enchanting Dream under the Southern Stars”, research. The ship” and an annual “Ray McGrath Medical is a showcase event and highly attended; our Institute provides Research Program Grant” in acknowledge- Direct Marketing program continues to grow ment of the many years of support, immense and is currently undertaking improvements to state-of-the-art generosity and passion for the Foundation provide even more support to research. facilities to do such over many years by both John and Ray; they research and we are will be sadly missed. The next year will continue to be a time of change for the Foundation. We are entering very proud of our The board and I also pass on our sincere a new era, an era of challenges, of positive involvement.” appreciation to Maurice Henderson, our change and of new directions. We will be exiting Executive Director, for his time at the seeking to continue on the growth path the Foundation and we wish Maurice all the very Foundation has taken over the last five years best for the future. and to diversify in our income development initiatives. 2009 has brought about many other changes for The Queen Elizabeth Hospital Research To lead The Queen Elizabeth Hospital Research Foundation. In March 2009 we saw the Foundation through this period is our newly opening of The Queen Elizabeth Hospital’s appointed CEO, Mr Paul Flynn. Paul comes $19 million research building, The Institute, to the Foundation with a wealth of experi- including the Basil Hetzel Institute for Medical ence in both the not-for-profit sector and the Research. Housing over 120 researchers and commercial world, and he has the passion students, The Institute is a physical reminder and enthusiasm to match. The board are of why TQEHRF exists – providing funds to looking forward to working with Paul and his assist medical research. The Institute provides team as we look to grow our recent success state-of-the-art facilities to do such research and continue to achieve what the Founda- and we are very proud of our involvement. tion exists for – providing vital funds to assist Our “Research Committee” continues to medical research. provide the board with a view as to the best allocation of funds. May I take this opportunity to thank you for your support over the past year, no matter After the incredible success of our 2009 Home how large or how small, all support is greatly Lottery, which saw all 56,000 tickets selling out appreciated in whatever manner that may be. before the early bird deadline, we launched the inaugural Lifestyles Lottery. Launching Lee Jameson, Chair in August, the Lifestyles Lottery resulted in The Queen Elizabeth Hospital Research an overwhelming success, also selling out all Foundation Board
TQEHresearch Research Report 2009 118 INCOME DEVELOPMENT INITIATIVES
The lucky winners of the $1.2 million home were Ray and Maria Brandt of Flagstaff Hill.
TQEHresearch Research Report 2009 119 “The tremendous TQEHRF seeks to maintain that its contri- In Memoriam Gifts bution to world-class medical research is TQEH Research Foundation’s In Memoriam success of the supported by ethical, innovative and well Gifts program provides a special way for Home Lottery led executed income development activities. friends and family members to remember to the launch of We are ever conscious that the brilliant and and honour a loved one whilst making hard-working scientists and research staff a life changing contribution to medical the first Lifestyles rely heavily on the productivity of our work research that will benefit all Australians. Lottery later and the generosity of our community. Making a gift in memory of a loved one is a thoughtful and generous gesture which in the year, represents an everlasting personal memorial allowing Life Guardian – Planned Giving that contributes to healthier solutions for Our planned giving program, Life our community. TQEHRF to make Guardians, offers individuals the opportu- an additional nity to leave a lasting legacy to research significant by making a gift in their will. Over 750 Lotteries supporters have made this generous The Dream Big…Win Big… theme for contribution to commitment, signifying a strong base for 2009 Home Lottery was a huge success, medical research future support of vital medical research at effectively supporting much needed TQEH. medical research at TQEH. The Home this year.” Lottery produced a record sell-out with all 56,000 tickets being sold 30 days before Basil Hetzel Society the Early Bird deadline. There were more We have a number of generous donors than 3800 prizes this year, ranging from a who have left gifts of $10,000 or more to spectacular Scott Salisbury Home, luxury support world-class medical research in vehicles, worldwide holidays and entertain- their wills, and The Basil Hetzel Society was ment prizes. The lucky winners of the $1.2 developed to acknowledge these special million home were Ray and Maria Brandt of and very generous contributors. Over Flagstaff Hill. The tremendous success of the 250 donors have already kindly made this Home Lottery led to the launch of the first commitment and have been acknowledged Lifestyles Lottery later in the year, allowing as members of this special group for their TQEHRF to make an additional significant generosity and commitment to future contribution to medical research this year. generations of Australians. The inaugural Lifestyles Lottery was launched to the public on August 13th Tribute Funds and again all tickets were sold before the TQEHRF’s Tribute Funds are a positive and Early Bird deadline. The prize package was simple way for family and friends to leave a fantastic with the winner able to choose lasting legacy to a loved one. A Tribute Fund either the Scott Salisbury Wentworth Show carries the name of a loved one and in their home for its undeniable opulence…or name; TQEHRF continues to ensure that take the $1.1 million dollars in cash. Other medical research takes place to improve the amazing prizes included the Family Fun health and well being of our community. Prize package, a line-up of vehicles that gave you your ‘keys to freedom’, ‘extraordi- Family and friends are able to support the nary escapes’, and ‘extravagant extras’. lasting legacy of their loved one in a number TQEHRF has had much success since 2004 of ways, such as making contributions on with our lotteries and gives credit to the significant dates such as anniversaries and valuable partnerships we have in this birthdays, by making monthly gifts or by community with our terrific supporters, choosing to host dinners, auctions or quiz prize suppliers, media partners and all nights. service providers.
In every activity undertaken, the lasting legacy of the family member or friend is forever linked to the constant search for better health outcomes for all future generations.
TQEHresearch Research Report 2009 120 (Pictured left to right): Eddie Liew, Jing Lee, Martin Hamilton-Smith, Events Stavroula Raptis, Silvia Toop.
The Queen Elizabeth Hospital Research General Sponsors, Peter Lehmann, Wirra Foundation holds many wonderful events Wirra, Coopers, Terry Howe Printing and throughout the year to support medical Traffic Creative. We also thank our generous research into illness and disease that impact auction item donors, in-kind supporters and the lives of numerous Australians. guests.
One of the major income development The Queen Elizabeth Hospital Research activities is the Annual Black Tie Dinner. Foundation was the beneficiary of several Through the generous support of corporate other major events throughout 2009 businesses and the wider South Australian including The Advertiser/Sunday Mail community, this event provides a significant Foundation Male Famous Faces Luncheon amount of support for medical research and the American Chamber of Commerce each year. It has made a name for itself (AMCHAM) Internode Lunches held throughout Adelaide and has become one throughout the year. of the anticipated dinners of the year. We have also been a beneficiary for many The 2009 ‘An Enchanting Dream Under the community based fundraisers including the Southern Stars’ Dinner was no different Women’s Group of the Pierkos Society, Port and was about celebrating the wonders of Wakefield Golf Day and Italian Fundraiser Australia with fine food, wine and fantastic Dinner Dance. We thank our community entertainment while raising funds for vital groups for their ongoing support, passion funds to support medical research at The and devotion to TQEHRF. Queen Elizabeth Hospital. The dinner was a success, raising more than $70,000 toward research into cancer at TQEH.
One of the highlights of the night was the $100 a ticket raffle, which gave the opportunity for one lucky person to win a 1 carat round brilliant cut diamond valued at $8,500. This was kindly donated by Maria Kenda of KendaCraft Jewellery. The lucky winner was Janice Schutze and was drawn by Wayne Phillips, our MC for the evening.
Special thanks must go to our Platinum Sponsor, Nova Defence, Gold Sponsors, S.O Asher Consultants, Panurgem, Australian Construction Surveys, Scott Salisbury Homes, Channel 9 and SGIC. Thank you also to our Silver Sponsors, Charterhouse, Bank SA, SeaRay Sales, Australian Post and McGrath Real Estate. Raffle Game Sponsor, KendaCraft Jewellery,
TQEHresearch Research Report 2009 121 Development Dry July
Direct Mail In 2009 The Queen Elizabeth Hospital Direct mail is one of the many ways that Research Foundation won the fantastic we keep in contact with members of opportunity to be the beneficiary for the our community that regularly support innovative fundraising initiative, Dry July. the world-class medical research at The Institute. Dry July was founded in 2008 when three heavy drinking guys from Sydney decided to We also use Direct mail to contact those embrace sobriety for a month, get healthy members of our community who may wish and raise some money for charity. The to support medical research in a meaningful program was a huge success and signifi- way. Our regular communication informs cant funds were raised for the Prince of supporters about specific research projects Wales Hospital Foundation in Sydney. Due undertaken at The Institute and detail news to the success of Dry July in its first year, the items about individuals who have benefited program was extended nationally in 2009 directly from “bench to bedside” transla- with beneficiaries in each state. tional research at The Institute. In 2009, over $1.26 million was raised We also regularly keep in touch with nationwide for hospitals in each state. In supporters and potential donors by phone. South Australia, over $54,000 was raised We see this as an easy and effective way and will go towards improving the lives to spread the word about the important of adults living with cancer at The Queen Top: (Pictured left to right): research being conducted at The Institute. Elizabeth Hospital. Mr Phil Grove, Mr Brett Many people in the community have been MacDonald, Dr Petra inspired in this way to support the endeav- South Australian celebrity ambassadors Neufing, A/Prof Richard D’Andrea, Kristin Linke, ours of the researchers and scientists who participated in and supported Dry July Dr John Norman, Maureen at The Institute in their effort to deliver include Shaun Burgoyne, Matthew Abraham Tremaine life-changing clinical outcomes to all from 891 ABC Adelaide, Keith Conlon and Bottom: (Pictured left to Australians. A highly effective part of this Tony Pilkington from Five AA and Ryan right): Dr Ken Pittman, process is via the Key Medallion Program ‘Fitzy’ Fitzgerald from Nova 91.9 and patient Brian Page and Dry which not only supports our research TQEHRF thanks them all for their valuable July Ambassador Shaun Burgoyne endeavours but also provides a valuable key support. safety service to members of the club. The use of the funds raised through Dry There are a large group of long-time July was to be focussed largely on patient supporters of medical and health research benefits. At the time that this report went who have chosen to establish a program of to print the Oncology Department at regular giving. This provides a high level of TQEH were still in the process of finalising surety to the researchers in their ongoing how exactly the funds raised would be search for world-class medical and health used to improve the lives of patients living improvements. with cancer in the hospital. A number of options being considered include laptops with internet access for patients to keep in contact with friends and family, a flat screen plasma TV for the waiting rooms and a number of comfortable treatment chairs for patients.
TQEHresearch Research Report 2009 122 The Institute Opening Supporting Students
In March 2009, The Queen Elizabeth at TQEH Hospital’s $19 million state-of-the-art Nurturing and supporting talented students research building, The Institute, opened is a high priority for The Queen Elizabeth for business, heralding an exciting new era Hospital Research Foundation. Each year, in medical research and patient benefits in TQEHRF supports students by granting South Australia. scholarships. More than 120 researchers and students In 2009, the Research Foundation moved from the former nursing accommo- supported 12 Postgraduate students, dation building at the hospital into the 9 Honours students and four vacation striking purpose-built three-level building. scholarships. The building was officially opened and Research Day dedicated by the Health Minister The Hon The Research Foundation was again the John Hill MP on March 2nd which coincided major supporter of The Queen Elizabeth with the 50th anniversary of the opening of Hospital Research Day, the most significant the main hospital building at TQEH. annual event in the research calendar at TQEH. This event is aimed at providing an The new building represents the largest opportunity for young student researchers amount of money ever spent by the State to present their data before an audience Government on a specialist medical research under conditions which are typical of most centre. TQEHRF immediately committed national and international scientific confer- Top: (Pictured left to right): $500,000 for new research equipment Gordon & Joyce Watson, ences. Students receive awards in various to be housed in the new building for its Jerry Witkowski, John & categories, with most of the awards being Maree Mufford. commencement of operations. sponsored by The Queen Elizabeth Hospital Bottom: (Pictured left to Research Foundation. TQEHRF hosted a cocktail party to showcase right): Joanna Jensen, Prof Basil Hetzel & the new building and celebrate its opening. Research Day in 2009 was held for the Mary Jepson About 100 people, representing generous first time in the new research facility, supporters of medical research in Australia, The Institute (BHI), and the organising the scientific community and the represent- committee was delighted to receive a record atives of the Department of Health in South 42 Abstracts, a reflection of the great Australia attended the function held in the research ethos of the new building. atrium of the building.
Special guests included the Minister for Health, The Hon John Hill MP, the Minister for Science, The Hon Paul Caica MP, the Mayor of Charles Sturt, Harold Anderson, the Mayor of Port Adelaide-Enfield, Gary Johanson and Dr Basil Hetzel AC.
A generous cheque from one of TQEHRF’s largest donors Gordon Pickard was presented by his representative Ron Wall and will go towards the ongoing research at The Institute.
(Pictured rear left to right): Prof Basil Hetzel, Dr Andrew Foreman, Dr Michael Collins, Mr Raymond Yu, Dr Shaundeep Sen, Prof Guy Maddern (Front left to right): Ms Darling Rojas, Ms Nicole Such, Ms Kanchani Rajopadhyaya
TQEHresearch Research Report 2009 123 “This RAC system Allocation Of Funding the researchers. The chair of this committee is vital as it allows is required to be a member of The Queen Research Advisory Committee Elizabeth Hospital Research Foundation board money to be To ensure accountability of money spent and and is currently Professor Richard Ruffin. allocated on to ensure a transparent transfer of funds from The Queen Elizabeth Hospital Research In 2008 the RAC (constituted without conflict strong academic Foundation to researchers at The Queen of interest) chaired by Prof Rob Norman and basis and scientific Elizabeth Hospital, TQEHRF funding is gifted assisted by Prof Heddy Zola, made recommen- dations to fund five program grants within capability, and is on a competitive application basis. To ensure this application and review process is fair and The Institute/TQEH for 3-5 years. The RAC an important step equitable, TQEHRF established a Research recommendations were accepted by the board towards creating Advisory Committee (RAC) in 2007. This of directors, and grant funding commenced in committee is comprised of esteemed South early 2009. An annual review of the progress an impartial system Australian researchers and has representa- will monitor each program grant. that demonstrates tion from The Queen Elizabeth Hospital, This RAC system is vital as it allows money to consistency across Children’s Health Research Institute, Women’s and Children’s Hospital and the three South be allocated on strong academic basis and all funding by Australian Universities. scientific capability, and is an important step TQEHRF.” towards creating an impartial system that The Committee determines the best way to demonstrates consistency across all funding allocate the money donated by TQEHRF to by TQEHRF.
Funding Research Projects The following table outlines the allocation of support TQEHRF has provided to research at The Queen Elizabeth Hospital.
The Queen Elizabeth Hospital Research Foundation Inc. Distribution of Funds to Research in 2008-09
Detail of Funds $ The Institute $220,000 New research equipment $554,829 Program Grants $607,500 Commercialisation $274,678 Other Research Distribution $40,939 Targeted funds: - Breast cancer $23,641 - Cancer research $25,423 - Cardiology $26,081 - Department of Medicine $10,550 - Endocrine & Diabetes $2,756 - Intensive care $17,500 - Neurology $4,875 - ANR neurology $1,356 - Oncology / Hematology $22,779 - Renal research $7,419 - Respiratory $2,304 - Rheumatology $501 - Renal ward $9,290 - Pharmacokinetic drug study $250 - Western Palliative care $17,909 - Gastroenterology $1,860 - Clinical Pharmacology - R. Morris $5,000 - Dr. LW Tan (BioInnovation SA Commercial Development Grant) $62,420 - Research Day 2009; Posters $8,704 TOTAL funds provided towards research $1,948,564
TQEHresearch Research Report 2009 124 CREDITS
The Queen Elizabeth Hospital would like to acknowledge the contribution towards this report from the following:
Graphic design: Bridgehead Australia Pty Ltd
Printing: Finsbury Green
Photography: Basil Popowycz Ben Searcy Photography Ashley Turner The Advertiser Photography Department
Production: The Queen Elizabeth Hospital Research Foundation
CONTACTS
The Queen Elizabeth Hospital Research Secretariat 28 Woodville Road, Woodville South, South Australia 5011 P: (08) 8222 7836 F: (08) 8222 7872 E: [email protected] W: http://tqeh.sa.gov.au/public/content/default.asp?xcid=1823 The Queen Elizabeth Hospital Research Foundation, 50 Woodville Road Woodville South SA 5011 P: 82441100 | F: 82441200 | W: www.tqehresearch.com.au