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Tqehresearch 2009 Research Report TQEHresearch 2009 Research Report TQEHresearch 2009 Research Report Contents 04 DIRECTOR OF RESEARCH REPORT 06 2009 RESEARCH PUBLICATIONS IN THE SPOTLIGHT 09 ANAESTHESIA, Department of 10 CARDIOLOGY UNIT 18 CLINICAL PHARMACOLOGY UNIT 21 DERMATOLOGY UNIT 22 ENDOCRINOLOGY UNIT 24 GASTROENTEROLOGY AND HEPATOLOGY UNIT 26 GYNAECOLOGY, Department of 28 HAEMATOLOGY AND MEDICAL ONCOLOGY, The combined Departments of 34 INTENSIVE CARE UNIT 39 MEDICINE, University of Adelaide Discipline of 44 NEUROLOGY UNIT 51 NUCLEAR MEDICINE UNIT 54 NURSING RESEARCH 55 OTOLARYNGOLOGY, HEAD AND NECK SURGERY, Department of 59 PSYCHIATRY, University of Adelaide Discipline of 61 RENAL UNIT 68 RESPIRATORY MEDICINE UNIT 70 RHEUMATOLOGY UNIT 72 SURGERY, University of Adelaide Discipline of 77 THERAPEUTICS RESEARCH CENTRE, University of South Australia 80 PUBLICATIONS 93 INVITED PRESENTATIONS 105 RESEARCH SUPPORT STRUCTURES 111 AWARDS 115 ACKNOWLEDGEMENTS 116 THE QUEEN ELIZABETH HOSPITAL RESEARCH FOUNDATION TQEHresearch Research Report 2009 2 TQEHresearch Research Report 2009 3 Professor Guy Maddern Director of Research Director of Research Report The Basil Hetzel Institute 2009 began with great enthusiasm as Alongside this move towards translational for Medical Research The groups moved into The Basil Hetzel Institute research has been the development of the Queen Elizabeth Hospital building at The Queen Elizabeth Hospital. South Australian Health and Medical Research Like all new buildings, there have been the Institute on North Terrace. The Common- inevitable problems in resolving small but wealth Government has allocated $200 irritating technical glitches but, at the time million to this new capital development and of writing this report, all but one major it is envisaged that it will have a central role problem has been satisfactorily resolved and for research in South Australia with a close the groups are enjoying their new environ- relationship to its nodes, such as the Basil ment. There can be little doubt the architec- Hetzel Institute, around the major hospitals ture has greatly facilitated co-operation not on the North Terrace precinct. This and a sense of camaraderie and team work relationship needs careful oversight and across the groups. This has led to much the next few years will be critical to ensure enthusiasm and interest in joining a number that appropriate structure, relationship and of the teams based at The Queen Elizabeth co-operation is developed. The great challenge Hospital and over the next 1–2 years it will be to use successfully all the research is anticipated a number of new research infrastructure in South Australia but have groups may well relocate to the facility. a co-ordinated approach to its endeavours and the funding available to support medical The other significant change over the last research. At this stage the general direction twelve months has been to develop five being adopted is positive and providing it is significant themes within the building carefully managed, there can be little doubt in order to optimise resources and focus that medical research within South Australia the efforts of the research community at will benefit from this enormous capital the hospital. Increasingly, the focus is on injection. The problem as always is to ensure translational research. This is particularly adequate recurrent funds are available to keep appropriate as the great strength of the staffed such a large and complex vision. Basil Hetzel Institute is its very close link to patient care. There is an abundance of As we go forward into the next decade the questions that need to be answered about site at The Queen Elizabeth Hospital has the patients being treated at the hospital adequate space for a further doubling of the and using the research infrastructure to Research Institute size and efforts to obtain tackle some of these important questions funding and groups for this are now being seems logical and appropriate. actively pursued. TQEHresearch Research Report 2009 4 “There is an abundance of questions that need to be answered about the patients being treated at the hospital and using the research infrastructure to tackle some of these important questions seems logical and appropriate.” TQEHresearch Research Report 2009 5 “The great challenge 2009 Research Publications in the spotlight in Neurology is how to repair the brain Perugini M, Kok CH, Brown AL, Wilkinson The 2009 H1N1 virus is very topical and following damage CR, Salerno DG, Young SM, Diakiw SM, had a substantial effect on ICUs during from stroke, Lewis ID, Gonda TJ, D’Andrea RJ. Repres- the winter in Australia and New Zealand. sion of Gadd45alpha by activated FLT3 and This publication will assist planning for the neurodegenerative GM-CSF receptor mutants contributes to treatment of patients during the winter in diseases (such as growth, survival and blocked differentiation. the Northern Hemisphere. A/Professor Sandra Parkinson’s and Leukemia 2009; 23:729-738. Peake is a member of the study Management Committee. Alzheimer’s disease) Impact Factor: 8.6 and trauma.” The publication from Richard D’Andrea’s Arthur A, Shi S, Zannettino AC, Fujii N, group in Leukemia in 2009 describes the Gronthos S, Koblar SA. Implanted adult role of a growth regulatory gene (encoding human dental pulm stem cells induce the Growth Arrest and DNA Damage 45 endogenous axon guidance. Stem Cells 2009: alpha protein) that is down-regulated in 27(9):2229-37. Acute Myeloid Leukaemia (AML), particularly in AML’s that harbour the common FLT3 Stem Cells impact factor 7.9 mutation. In dissecting the mechanism by which leukaemic cells alter expression of this ‘Regenerative medicine is a new and exciting gene and obtain a growth advantage this field which involves stem cell biology and work has described an important change surgical transplantation to treat a myriad of that can be potentially targeted in the diseases. The great challenge in Neurology treatment of AML. Importantly this study is how to repair the brain following damage included cell line studies and studies with from stroke, neurodegenerative diseases AML patient samples validating the role of (such as Parkinson’s and Alzheimer’s disease) this pathway. These studies set the stage for and trauma. The data from this study was mouse experiments to determine the ability highly significant as it demonstrated for the of this pathway to cooperate with other first time how adult human stem cells from events that contribute to AML. the tooth produce factors which can actively rewire the nervous system. This finding has led to pre-clinical animal studies looking at ANZIC Influenza Investigators, Webb SA, how stem cell therapy may repair the brain Pettilä V, Seppelt I, Bellomo R, Bailey M, following a stroke. The work was undertaken Cooper DJ, Cretikos M, Davies AR, Finfer by the Stroke Research Programme which is a S, Harrigan PW, Hart GK, Howe B, Iredell collaboration between the laboratories at the JR, McArthur C, Mitchell I, Morrison S, Basil Hetzel Institute for Medical Research, Nichol AD, Paterson DL, Peake S, Richards TQEH, the School for Molecular and Biomed- B, Stephens D, Turner A, Yung M. Critical ical Sciences, University of Adelaide and a care services and 2009 H1N1 influenza in long-term collaborator A/Prof Stan Gronthos Australia and New Zealand. N Engl J Med. from the Division of Haematology, Hanson 2009 Nov 12; 361(20):1925-34. Institute, Adelaide.’ This publication has been published by the Foreman A, Singhal D, Psaltis AJ, Wormald New England Journal of Medicine, the top PJ. Targeted imaging modality selection for ranked journal. The investigators were able bacterial biofilms in chronic rhinosinusitis. to obtain 100% case ascertainment for all Laryngoscope 2009; Nov 30. [Epub ahead of Australia and New Zealand and calculated print] per million inhabitants, the numbers of ICU admissions, bed-days, and days of mechan- Impact Factor 1.8 ical ventilation due to infection with the 2009 H1N1 virus. Data was also collected Chronic Rhinosinusitis (CRS) is an extremely on demographic and clinical characteris- common condition, encountered regularly by tics of the patients and on treatments and all ENT surgeons. However it is a challenging outcomes. condition to manage because current TQEHresearch Research Report 2009 6 therapeutic regimes lack specificity. This is HL in a representative sample of people with “The results of this primarily because the underlying pathogen- asthma has not been reported however. In esis of this condition is poorly understood subjects with asthma identified in the 2008 research provide and therefore treatment options cannot be South Australian Health Omnibus Study, evidence-based specifically targeted against an underlying increased symptoms, functional impairment, guidelines to cause. Recently biofilms have been proposed and significant health care use were more as a potential instigator of this disease and common in people with less HL in analyses assist researchers the role they play in CRS has developed into adjusted for age, sex, and education. This in identifying one of the hottest topics in ENT research. suggests that HL is not merely acting as a Clinically this is a highly relevant area of proxy for education. Asthma itself, however, situations in which research because unlocking the pathogenesis was not increased in people with low health each technique is of CRS will eventually enable the develop- literacy, consistent with the notion that HL ment of targeted anti-biofilm treatments affects asthma management and interac- ideally suited and that can improve the outcomes of our CRS tions with health services rather than factors ensures they select patients. In the mean time our primary associated with the development of asthma. the appropriate research aim is to better understand the These findings indicate that the considera- nature and specific characteristics of bacteria tion of HL across all asthma clinical practice technique that is within the biofilms as well as outline the host and self-treatment education should be a best able to answer response to these bacterial colonies.
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