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2017HFA Congress 2017 HFA Congress Heart Failure Association 29 april - 2 may 2017 • paris • france EVIEWED R PEER- CONFERENCE CONFERENCE REPORT Late Breaking Trials Heart Failure and Diabetes Biomarkers in Acute Heart Results from the multicentre It is important to choose the right Failure RELAX-AHF-2 trial: no significant anti-diabetic in patients with acute Biomarkers become the corner- safety concerns using serelaxin. and chronic heart failure, because stone in the diagnosis and The trial showed encouraging data, not all anti-diabetics are heart- prognostication of heart failure, particularly on troponin release friendly. they are indispensable for the and the impact on worsening of daily clinical practice. heart failure in the hospital. read more on PAGE 3 read more on PAGE 8 read more on PAGE 12 Editor Prof. dr. Rudolf de Boer, University of Groningen, the Netherlands MEDIC AL PUBLISHERS Contents Letter from the Editor Interview: Prof. Frank Ruschitzka, President of the HFA COLOPHON 3 Late-Breaking Trials Editor Prof. dr. Rudolf de Boer 3 I: Focus on acute heart failure University of Groningen, the Netherlands Advisory Board Prof. dr. Hans-Peter Brunner-La Rocca 4 II: Chronic heart failure University of Maastricht, the Netherlands 6 III: Innovative and device therapies Prof. dr. Jaap W. Deckers Erasmus University Rotterdam, the Netherlands 8 Heart Failure and Diabetes – A Dangerous Liaison Editorial Manager Lisa Colson Editorial Co-ordinators Dr. Rose-Minke Schure 10 Acute Heart Failure and the Quest for the Ideal Therapy Bas Braakman, MSc. Executive Publisher Rene Draper, MSc. Medical Writer Dr. Susanne Kammerer 12 Biomarkers in Acute Heart Failure Dr. Kirsten Westphal 12 Biomarkers: an important diagnostic tool in acute heart failure Production Manager Desiree Heijl Graphic Design 12 Biomarkers in acute heart failure MOOZ grafisch ontwerp 14 Grand Debate: Vasodilators under the Spotlight All rights reserved. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of 15 Poster Sessions 2017 the publisher, except in the case of brief quotations embodied in critical reviews and certain other noncommercial uses permitted by copyright law. 15 New predictors of left ventricular hypertrophy: Insights from Copyright ©2017 Medicom Medische Uitgeverij BV an epidemiologic survey Disclaimer: 15 Similar Comorbidities in heart failure with reduced or preserved The ideas and opinions expressed in this journal or other associated publications do not necessarily reflect those of Medicom Medical ejection fraction Publishers. Although great care has been taken in compiling the content of this publication, Medicom is not responsible or liable in any way for the 16 Higher cardiovascular risk in carriers of non-O blood groups currency of the information, for any errors, omissions or inaccuracies in the original articles, or for any consequences arising from the content. Approved 16 Demographic change results in need for heart failure clinics product information should be reviewed before prescribing. The mention of any product, service, or therapy in this publication should not be construed 16 Public knowledge about heart failure is improving as an endorsement of the products mentioned. It is the responsibility of the treating physician or other health care provider, relying on independent 17 Similar biomarker profile in HFmrEF and HFrEF patients experience and knowledge of the patient, to determine drug dosages and the best treatment for the patient. Readers are advised to check 17 Interactive smartphone application improves adherence in the appropriate medical literature and the product information currently HF patients provided by the manufacturer of each drug to be administered to verify the dosage, method, and duration of administration, or contraindications. Readers are also encouraged to contact the manufacturer with questions 17 Troponin increases in amateur marathon runners about the features or limitations of any products. Medicom assumes no 18 Brain natriuretic peptide improves risk stratification in cardiac responsibility for any injury or damage to persons or property arising out of or related to any use of the material contained in this publication or to any surgery errors or omissions. 18 Discharge checklist for HF patients reduces readmission rates MEDIC AL PUBLISHERS Postal address Head Office Medicom Medical Publishers Medicom Medical Publishers PO Box 90 Faas Eliaslaan 5 Zipcode 3740 AB 3742 AR Baarn City Baarn The Netherlands Country The Netherlands Telephone +31 85 4012 560 Fax +31 85 4012 569 E-mail [email protected] ISSN 2468-8765 17:7 Letter from the Editor Prof. dr. Rudolf de Boer Dear Reader, Biography Rudolf de Boer (1972, Gouda, This years’ ESC HF congress was hosted by the City of the Netherlands) is a Clinical Cardiologist and a Full Light, Paris. The congress is one of the flagships of the Professor of (Translational) Heart Failure Association (HFA) of the European Society of Cardiology at the University Cardiology (ESC), welcoming well over 5,000 attendants. Medical Center Groningen. He studied medicine in Groningen The congress kicked off with two major trials: the and completed a post-doctoral RELAX-AHF 2 (serelaxin) and TRUE-HF (ularitide), fellowship at Harvard Medical School, Boston, USA. which were simultaneously published in the New His basic research focuses on England Journal of Medicine. Another major focus of cardiac remodeling, fibrosis, the congress was the implementation of the 2016 heart metabolic changes and failure guidelines, featuring several sessions with lively diabetes. He connects discussions. Further, the growing epidemic of heart mechanisms with clinical data failure with preserved ejection fraction was discussed, e.g. from the LifeLines study, of which he was a founding and experts from other fields such as diabetes and atrial member the scientific fibrillation discussed their importance. A growing and committee. His clinical successful track is the basic and translational track, in interests span from inherited which working mechanisms of old and new drugs, of cardiomyopathies to end-stage cardiomyopathies and other aspects of HF are addressed heart failure. in more detail. Dr. de Boer has authored and co-authored over 250 articles in peer reviewed journals and Paris was a fantastic venue, the Palais de Congrès being wrote over 10 book chapters. centrally located within walking distance of l’Arc de He was appointed a Fellow of Triomphe, les Champs-Elysées, and la Tour Eiffel. the European Society of ESC HF 2017 turned out to be a wonderful “rendez- Cardiology (ESC) in 2010, is vous with the future’’ and next years’ congress will be the current the president of the Heart Failure Working Group of in another historical and vibrant city, Vienna, with the the Dutch Society of Cardiology theme: “classical repertoire, modern instruments’’. and Board Member and Chair I sincerely hope to meet all of you again! of the Basic Section of the Heart Failure Association (HFA) With my warmest regards, of the ESC. Rudolf de Boer Cardiologist, UMC Groningen, the Netherlands Fellow of the European Society of Cardiology (FESC) Fellow of the Heart Failure Association (FHFA) HFA Board member CONFERENCE REPORT - HFA 2017 Interview with Prof. dr. Frank Ruschitzka University Hospital Zürich (Switzerland), president of the Heart Failure Association (HFA) Interview by Dr. Susanne Kammerer Heart failure is moving truly towards centre stage " within cardiology " What are the highlights of this year’s Heart Failure from over 100 countries. It's not only the size that matters, convention? the energy, the positive vibe at this congress was literally First of all, we had some exciting new trials being palpable – the rooms were packed throughout the congress. presented in the field of acute heart failure which well, in If you are looking for networking, for science, for a way, were a bit sobering, though. Thus, the RELAX-HF education, or if you want to get an update on the latest trial with 6,600 patients in acute heart failure assessing developments in heart failure, this is the place to go. Heart the hormone serelaxin was presented. Physiologically, failure is the one speciality within cardiology that is moving this hormone prepares the expecting mother for the truly towards centre stage. hemodynamic challenges of pregnancy, thus providing the rationale for testing this hormone in patients with acute Regarding acute heart failure, do you think there are any heart failure. Unfortunately, it showed us that short term new biomarkers which could allow us to identify patients infusion for 48 hours doesn't improve outcomes six months earlier? later. It is a daunting proposition to think that the short- Biomarkers remain surrogates, surrogates of outcome. term infusion would change outcomes after six months. There was to some extent a disconnection between There were some encouraging data with this drug presented, biomarkers and clinically relevant outcomes in TRUE-AHF though, particularly on troponin release and the impact on and RELAX-AHF. Indeed, serelaxin reduced troponin and worsening of heart failure in the hospital. didn’t impact the outcome. On the other hand, ularatide did We also heard the results of the TRUE-AHF trial that I was not reduce troponin levels, but was associated with lower involved in. In this trial patients were treated with ularitide, N-terminal pro-brain natriuretic peptide levels. the chemically synthesized form of the human natriuretic peptide urodilatin. Similar to RELAX-AHF, TRUE-AHF was Are there any new features integrated in this years’ neutral on the primary outcome. Interestingly, Milton congress? Packer presented results from a post hoc analysis that only We have lots of new features in this year´s meeting. For included eligible patients. In this post-hoc analysis, ularitide example, how do I translate guidelines into practice? The provided at least some symptom relief. This comes with all major hurdle in guideline implementation is that the doctors, the cautionary remarks of a post-hoc analysis, though.
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