Anti-OTUB1 Monoclonal Antibody, Clone FQS24138(C) (DCABH-6470) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Anti-OTUB1 monoclonal antibody, clone FQS24138(C) (DCABH-6470) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Rabbit monoclonal to OTUB1 Antigen Description Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128- mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of Lys-48-linked polyubiquitin chains, but not Lys-63-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a nuch lower preference compared to Lys- 48-linked ubiquitin. Immunogen Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human OTUB1 aa 50-150 (Cysteine residue). The exact sequence is proprietary.Database link: Q96FW1 Isotype IgG Source/Host Rabbit Species Reactivity Mouse, Rat, Human Clone FQS24138(C) Purity Tissue culture supernatant Conjugate Unconjugated Applications WB Positive Control MCF7, HeLa, HepG2 and 293T cell lysates. Format Liquid Size 100 μl 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Preservative None Storage Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Ship Shipped at 4°C. GENE INFORMATION Gene Name OTUB1 OTU domain, ubiquitin aldehyde binding 1 [ Homo sapiens ] Official Symbol OTUB1 Synonyms OTUB1; OTU domain, ubiquitin aldehyde binding 1; ubiquitin thioesterase OTUB1; FLJ20113; FLJ40710; otubain-1; OTU-domain Ubal-binding 1; deubiquitinating enzyme OTUB1; ubiquitin- specific protease otubain 1; ubiquitin-specific-processing protease OTUB1; OT Entrez Gene ID 55611 Protein Refseq NP_060140 UniProt ID B3KUV5 Chromosome Location 11q13.1 Function NEDD8-specific protease activity; cysteine-type peptidase activity; omega peptidase activity; peptidase activity; protein binding; ubiquitin binding; ubiquitin-specific protease activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

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Theranostics OTUB2 Stabilizes U2AF2 to Promote the Warburg Effect and Tumorigenesis Via the AKT/Mtor Signaling Pathway in Non-Sm
Theranostics 2019, Vol. 9, Issue 1 179 Ivyspring International Publisher Theranostics 2019; 9(1): 179-195. doi: 10.7150/thno.29545 Research Paper OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer Jing Li1*, Dongdong Cheng2*, Miaoxin Zhu1, Huajian Yu1, Zhen Pan2, Lei Liu1, Qin Geng1, Hongyu Pan1, Mingxia Yan1, Ming Yao1 1. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2. Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China * These authors contributed equally to this work. Corresponding author: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 25/2200, Xietu Road, Shanghai 200032, China. Tel: +86 2164183618; Fax: +86 21 64042002. Email: [email protected]; [email protected] © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. Received: 2018.08.28; Accepted: 2018.11.25; Published: 2019.01.01 Abstract Increasing evidence has confirmed that deubiquitinating enzymes play an important role in lung cancer progression. In the current study, we investigated the expression profile of deubiquitinating enzymes in non-small cell lung cancer (NSCLC) tissues and identified OTUB2 as an upregulated deubiquitinating enzyme. The role of OTUB2 in NSCLC is unknown. Methods: Quantitative, real-time PCR and Western blot were used to detect OTUB2 and U2AF2 expression in NSCLC tissues.
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