Otubain-1 (OTUB1) (1-271, His-Tag) Human Protein Product Data

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Otubain-1 (OTUB1) (1-271, His-Tag) Human Protein Product Data

OriGene Technologies, Inc. 9620 Medical Center Drive, Ste 200 Rockville, MD 20850, US Phone: +1-888-267-4436 [email protected] EU: [email protected] CN: [email protected] Product datasheet for AR09235PU-N Otubain-1 (OTUB1) (1-271, His-tag) Human Protein Product data: Product Type: Recombinant Proteins Description: Otubain-1 (OTUB1) (1-271, His-tag) human recombinant protein, 0.1 mg Species: Human Expression Host: E. coli Tag: His-tag Predicted MW: 33.4 kDa Concentration: lot specific Purity: >95% by SDS - PAGE Buffer: Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris buffer (pH 8.0) containing 10% glycerol Preparation: Liquid purified protein Protein Description: Recombinant OTUB1 protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques. Storage: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Stability: Shelf life: one year from despatch. RefSeq: NP_060140 Locus ID: 55611 UniProt ID: Q96FW1, B3KUV5 Cytogenetics: 11q13.1 Synonyms: HSPC263; OTB1; OTU1 This product is to be used for laboratory only. Not for diagnostic or therapeutic use. View online » ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 1 / 2 Otubain-1 (OTUB1) (1-271, His-tag) Human Protein – AR09235PU-N Summary: The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin- dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] Protein Families: Protease Product images: This product is to be used for laboratory only. Not for diagnostic or therapeutic use. ©2021 OriGene Technologies, Inc., 9620 Medical Center Drive, Ste 200, Rockville, MD 20850, US 2 / 2.

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Theranostics OTUB2 Stabilizes U2AF2 to Promote the Warburg Effect and Tumorigenesis Via the AKT/Mtor Signaling Pathway in Non-Sm
Theranostics 2019, Vol. 9, Issue 1 179 Ivyspring International Publisher Theranostics 2019; 9(1): 179-195. doi: 10.7150/thno.29545 Research Paper OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer Jing Li1*, Dongdong Cheng2*, Miaoxin Zhu1, Huajian Yu1, Zhen Pan2, Lei Liu1, Qin Geng1, Hongyu Pan1, Mingxia Yan1, Ming Yao1 1. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2. Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China * These authors contributed equally to this work. Corresponding author: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 25/2200, Xietu Road, Shanghai 200032, China. Tel: +86 2164183618; Fax: +86 21 64042002. Email: [email protected]; [email protected] © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. Received: 2018.08.28; Accepted: 2018.11.25; Published: 2019.01.01 Abstract Increasing evidence has confirmed that deubiquitinating enzymes play an important role in lung cancer progression. In the current study, we investigated the expression profile of deubiquitinating enzymes in non-small cell lung cancer (NSCLC) tissues and identified OTUB2 as an upregulated deubiquitinating enzyme. The role of OTUB2 in NSCLC is unknown. Methods: Quantitative, real-time PCR and Western blot were used to detect OTUB2 and U2AF2 expression in NSCLC tissues.
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Anti-OTUB1 Monoclonal Antibody, Clone FQS24138(C) (DCABH-6470) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use
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