biomolecules Article Transcriptome Analysis Identifies Doublesex and Mab-3 Related Transcription Factor (DMRT3) in Nasal Polyp Epithelial Cells of Patients Suffering from Non-Steroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease (AERD) V.S. Priyadharshini 1 , Marcos Alejandro Jiménez-Chobillon 1, Jos de Graaf 2, Raúl Porras Gutiérrez de Velasco 3, Christina Gratziou 4, Fernando Ramírez-Jiménez 1 and Luis M. Teran 1,3,* 1 Instituto Nacional de EnfermedadesRespiratorias Ismael Cosío Villegas, Calz. de Tlalpan 4502, Belisario Domínguez Secc 16, Mexico City 14080, Mexico;
[email protected] (V.S.P.);
[email protected] (M.A.J.-C.);
[email protected] (F.R.-J.) 2 Translational Oncology at Johannes Gutenberg-University Medical Center gGmbH, D-55131 Mainz, Germany;
[email protected] 3 School of Medicine, Universidad Nacional Autónoma de México, Av. Universidad 3000, Circuito Exterior S/N. Delegación Coyoacán, Mexico City 04510, Mexico;
[email protected] 4 Smoking Cessation Centre Pulmonary Department, Evgenidio Hospital, Athens University, 20 Papadiamantopoulou Street, 11528 Athens, Greece;
[email protected] * Correspondence:
[email protected] Citation: Priyadharshini, V.S.; Jiménez-Chobillon, M.A.; de Graaf, J.; Abstract: Background: Aspirin-exacerbated respiratory disease (AERD) is a syndrome characterised Porras Gutiérrez de Velasco, R.; by chronic rhinosinusitis, nasal polyps, asthma and aspirin intolerance. An imbalance of eicosanoid Gratziou, C.; Ramírez-Jiménez, F.; metabolism with anover-production of cysteinyl leukotrienes (CysLTs) has been associated with Teran, L.M. Transcriptome Analysis AERD. However, the precise mechanisms underlying AERD are unknown. Objective: To establish Identifies Doublesex and Mab-3 the transcriptome of the nasal polyp airway epithelial cells derived from AERD patients to discover Related Transcription Factor (DMRT3) gene expression patterns in this disease.