Curriculum Vitae V I C T O R W

CURRICULUM VITAE V I C T O R W. R O D W E L L E M E R I T U S P R O F E S S O R O F B I O C H E M I S T R Y

Address: Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907-1153 Telephone: (765) 494-1608; FAX (765)494-7897 [email protected] Date of Birth: Sept. 10, 1929 Marital Status: Married Citizenship: U.S.

Education

1947-51 B.S. Wilson Teachers College, Washington, DC - Chemistry 1951-52 M.S. George Washington U., Washington, DC - Biochemistry 1952-54 Univ. of Wisconsin, Madison, WI - Physiological Chemistry 1954-56 Ph.D. Univ. of Kansas, Lawrence, KS - Biochemistry 1956-58 Postdoc. Univ. of California, Berkeley, CA - Biochemistry

Research and Professional Experience

2004-present Emeritus Professor, Biochemistry, Purdue University 1965-2004 Assoc. Prof. and Professor, Biochemistry, Purdue University 1958-65 Asst. Prof., Biochemistry, Univ. of California, San Francisco Medical Center 1956-58 USPHS Postdoctoral Fellow, Biochemistry, University of California, Berkeley 1951-56 Graduate Student, George Washington U., Univ. of Wisconsin, Univ. of Kansas

Honors

Helen Hay Whitney Foundation Predoctoral Fellow, Wisconsin (1952-54) USPHS Postdoctoral Fellow, Berkeley (1956-58) Purdue Alumni Association Helping Students Learn Award" (1984) Purdue Presidential Affirmative Action Award (1985) Purdue One Brick Higher Award (2003) Purdue School of Agriculture Outstanding Graduate Educator Award (2004)

Publications

Alpen EL, Mandel HG, Rodwell VW, and PK Smith. 1951. The metabolism of 14C carboxyl salicylic acid in the dog and in man. J. Pharm. Exp. Therap. 102, 150-155. Mandel HG, Smith PK, and Rodwell, VW. 1952. A study of metabolism of 14C salicylamide in the human. J. Pharm. Exp. Therap. 106, 433-439. Rodwell VW, Towne JC, and Grisolia S. 1956. Crystalline phosphoglyceric acid mutase. Biochim. Biophys. Acta 20, 394-396. Towne JC, Rodwell VW, and Grisolia S. 1957. The microestimation, distribution, and biosynthesis of 2,3-diphosphoglyceric acid. J. Biol. Chem. 226, 777-778. Rodwell VW, Towne JC, and Grisolia S. 1957. The kinetic properties of yeast and muscle phosphoglyceric acid mutase. J. Biol. Chem. 228, 875-890. 3

Edeloch H, Rodwell VW, and Grisolia S. 1957. The molecular properties of yeast and muscle phosphoglyceric acid mutase. J. Biol. Chem. 228, 891-903. Towne J, Rodwell VW, and Grisolia S. 1958. 2,3-Diphosphoglyceric acid. Biochem. Preps. 6, 12-15. Rodwell VW, Volcani BE, Ikawa M, and Snell EE. 1958. Bacterial oxidation of vitamin B6 I. Isopyridoxal and 5-pyridoxic acid. J. Biol. Chem. 233, 1548-1554. Berg RW, Rodwell VW, and Snell EE. 1958. Bacterial oxidation of vitamin B6. III. Metabolites of pyridoxamine. J. Biol. Chem. 235, 1555-1559. Ikawa M, Rodwell VW, and Snell EE. 1960. Bacterial oxidation of vitamin B6. II. Structure of "260 Compound". J. Biol. Chem. 235, 1164-1169. Mazumder RD, Sanadi R, and Rodwell VW. 1960. Purification and properties of hog kidney succinic thiokinase. J. Biol. Chem. 235, 2546-2550. Siddiqi MA, and Rodwell VW. 1962. Bacterial metabolism of mevalonic acid. Conversion to acetoacetate. Biochem. Biophys. Res. Commun. 8, 110-113. Rao DR, and Rodwell VW. 1962. Metabolism of pipecolic acid in a Pseudomonas species. I. -Aminoadipic and glutamic acids. J. Biol. Chem. 237, 2232-2238. Basso LV, Rao DR, and Rodwell VW. 1962. Metabolism of pipecolic acid in a Pseudomonas species. II. 1-Piperideine-6-carboxylic acid and -aminoadipic acid- -semialdehyde. J. Biol. Chem. 237, 2239-2245. Figmognari GM, and Rodwell VW. 1965. Cholesterol biosynthesis: Mevalonate synthesis inhibited by bile salts. Science 147, 1038. Figmognari GM, and Rodwell VW. 1965. Substrate-competitive inhibition of bacterial HMG-CoA reductase. Biochemistry 4, 2086-2090. Calvert AF, and Rodwell VW. 1966. Metabolism of pipecolic acid in a Pseudomonas species III. L- -Aminoadipate -semialdehyde:NAD+ oxidoreductase. J. Biol. Chem. 241, 409-414. Baginsky ML, and Rodwell VW. 1966. Metabolism of pipecolic acid in a Pseudomonas species IV. Electron transport particle of Pseudomonas putida. J. Bacteriol. 92, 424-432. Baginsky ML, and Rodwell VW. 1967. Metabolism of pipecolic acid in a Pseudomonas species V. Pipecolate oxidase and dehydrogenase. J. Bacteriol. 94, 1034-1039. Siddiqi MA, and Rodwell VW. 1967. Bacterial metabolism of mevalonic acid. J. Bacteriol. 93, 207-214. Reitz MS, and Rodwell VW. 1969. -Hydroxyglutarate oxidoreductase of Pseudomonas putida. J. Bacteriol. 100, 708-714. Reitz ML, Miller DL, and Rodwell VW. 1969. Synthesis of -aminovaleramide. Anal. Biochem. 28, 269-272. Shapiro DJ, Imblum RL, and Rodwell VW. 1969. Thin-layer chromatographic assay for HMG-CoA reductase and mevalonic acid. Anal. Biochem. 31, 383-390. Shapiro DJ, and Rodwell VW. 1969. Diurnal variation and cholesterol regulation of hepatic HMG-CoA reductase activity. Biochem. Biophys. Res. Commun. 37, 867-872. Fimognari GM, and Rodwell VW. 1970. Mevalonate biosynthesis in rat liver. Lipids 5, 104-108. McNamara DJ, Quackenbush FW, and Rodwell VW. 1970. Cycloheximide and chloramphenicol: Effects of rat liver acetate metabolism. Lipids 5, 146-148. Reitz ML, and Rodwell VW. 1970. -Aminovaleramidase of Pseudomonas putida. J. Biol. Chem. 245, 3091-3096. Bensch WR, and Rodwell VW. 1970. Purification and properties of HMG-CoA reductase from Pseudomonas. J. Biol. Chem. 245, 3755-3762. Miller DL, and Rodwell VW. 1971. Metabolism of basic amino acids in Pseudomonas putida. Properties of the inducible lysine transport system. J. Biol. Chem. 246, 1765-1771. Shapiro DJ, and Rodwell VW. 1971. Regulation of hepatic HMG-CoA reductase and cholesterol synthesis. J. Biol. Chem. 246, 3210-3216. Miller DL, and Rodwell VW. 1971. Metabolism of basic amino acids in Pseudomonas putida. Intermediates in L-arginine catabolism. J. Biol. Chem. 246, 5053-5058. 4

Hartline RA, and Rodwell VW. 1971. Metabolism of pipecolic acid in a Pseudomonas species. VI. Precursors of glutamate. Arch. Biochem. Biophys. 142, 32-39. Miller DL and Rodwell VW. 1971. Inactivation of L-lysine decarboxylase by L-lysine bromomethyl ketone. Biochem. Biophys. Res. Commun. 44, 1227-1233. Fan CL, Miller DL, and Rodwell VW. 1972. Metabolism of basic amino acids in Pseudomonas putida. Transport of lysine, arginine and ornithine. J. Biol. Chem. 247, 2283-2288. Chou C-S, and Rodwell VW. 1972. Metabolism of basic amino acid in Pseudomonas putida. -Guanidinobutyrate aminohydrolase. J. Biol. Chem. 247, 4486-4490. Jacobsen GB, and Rodwell VW. 1972. A Bacillus ribonucleic acid phosphodiesterase with associated 5'-nucleotidase activity. J. Biol. Chem. 247, 5811-5817. McNamara DJ, and Rodwell VW. 1972. Regulation of "Active isoprene" biosynthesis. In E. Kun and S. Grisolia (Eds.), Biochemical Regulatory Mechanisms in Eucaryotic Cells, Wiley, New York, pp. 205-243. Rodwell VW. 1972. Cholesterol regulation of hepatic HMG-CoA reductase. In J. Ganguly and R. M. S. Smellie (Eds.), Current Trends in the Biochemistry of Lipids, Academic Press, New York, pp. 295-301. Shapiro DJ, and Rodwell VW. 1972. Fine structure of the cyclic rhythm of HMG-CoA reductase: Differential effects of cholesterol feeding and fasting. Biochemistry 11, 1042-1045. McNamara DJ, Quackenbush FW, and Rodwell VW. 1972. Regulation of hepatic HMG-CoA reductase: Developmental pattern. J. Biol. Chem. 247, 5805-5810. Rodwell VW, McNamara DJ, and Shapiro DJ. 1973. Regulation of hepatic HMG-CoA reductase. Advan. Enzymol. 38, 373-412. Imblum RL, and Rodwell VW.1974. HMG-CoA reductase and mevalonate kinase of Neurospora crassa. J. Lipid Res. 15, 211-222. Shapiro DJ, Nordstrom JL, Mitschelen JJ, Rodwell VW, and Schimke RT. 1974. Micro assay for HMG-CoA reductase in rat liver and in L-cell fibroblasts. Biochem. Biophys. Acta 370, 369-377. McNamara DJ, and Rodwell VW. 1975. Regulation of hepatic HMG-CoA reductase: In vitro inhibition by a protein present in bile. Arch. Biochem. Biophys. 168, 378-385.. Fink DJ, and Rodwell VW. 1975. Kinetics of a hollow fiber dehydrogenase reactor. Biotech. Bioeng. 17, 1029-1050. Vanderbilt AS, Gaby NS, and Rodwell VW. 1975. Intermediates and enzymes between -ketoarginine and -guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida. J. Biol. Chem. 250, 5322-5329. Fan CL, and Rodwell VW. 1975. Physiological consequences of starvation in Pseudomonas putida: Degradation of intracellular protein and loss of activity of the inducible enzymes of L-arginine catabolism. J. Bacteriol. 124, 1302-1311. Brotherton JE, Emery A, and Rodwell VW. 1976. Characterization of sand as a support for immobilized enzymes. Biotech. Bioeng. 18, 527-543. Rodwell VW, Nordstrom JL, and Mitschelen JJ. 1976. Regulation of HMG-CoA reductase. Advan. Lipid Res. 14, 1-74. Young NL, and Rodwell VW. 1977. Regulation of HMG-CoA reductase in rat leukocytes. J. Lipid Res. 18, 572-581. Ladisch MR, Emery A, and Rodwell VW. 1977. Economic implications of purification of glucose isomerase prior to immobilization. Ind. Eng. Chem. Process Dev. 16, 309-313. Nordstrom JL, Mitschelen JJ, and Rodwell VW. 1977. Interconversion of active and inactive forms of rat liver HMG-CoA reductase. J. Biol. Chem. 252, 8924-8934. Keith ML, Rodwell VW, Rogers DH, and Rudney H. 1979. In vitro phosphorylation of HMG-CoA reductase: Analysis of 32P-labelled, inactivated enzyme. Biochem. Biophys. Res. Commun. 90, 969-975. Young NL, and Rodwell VW. 1980. Regulation of rat leukocyte HMG-CoA reductase: An application of quantitative TLC to a problem of clinical significance. In J. C. Touchstone and D. Rogers (Eds.), Thin-Layer Chromatography: Quantitative and Environmental Applications, Wiley, New York, pp. 426-441. 5

Brown WE, and Rodwell VW. 1980. HMG-CoA reductase (EC 1.1.1.34). In J. Jeffery (Ed.), Dehydrogenases Requiring Nicotinamide Coenzymes, Birkkhauser Verlag, Basel, Switzerland, pp. 232-272. Hunter CF, and Rodwell VW. 1980. Regulation of vertebrate liver HMG-CoA reductase via reversible modulation of its catalytic activity. J. Lipid Res. 21, 399-405. Brotherton JE, and Rodwell VW. 1980. Reversible inactivation of horse liver aldehyde dehydrogenase by 2-hydroxyethyl disulfide. Physiol. Chem. Physics 12, 483-495. Williamson IP, and Rodwell VW. 1981. Purification of HMG-CoA by ion-exchange chromatography. J. Lipid Res. 22, 184-187. Rodwell VW, and Bensch WR. 1981. (S)-3-Hydroxy-3-methylglutaryl-CoA reductase from Pseudomonas. Methods Enzymol. 71, 480-486. Voloche M, Ladisch MR, Rodwell VW, and Tsao GT. 1981. Separation of meso and racemic 2,3-butanediol by aqueous liquid chromatography. Biotech. Bioeng. 23, 1289-1296. Harwood HJ Jr, and Rodwell VW. 1982. HMG-CoA reductase kinase: Measurement of activity by methods that preclude interference by inhibitors of HMG-CoA reductase activity or by mevalonate kinase. J. Lipid Res. 23, 754-761. Brown WE, and Rodwell VW.1983. Purification and properties of two native, high molecular weight HMG-CoA reductase phosphatases. Biochim. Biophys. Acta 751, 218-229. Keith ML, Kennelly PJ, and Rodwell VW. 1983. Evidence for multiple phosphorylation sites in rat liver HMG-CoA reductase. J. Protein Chem. 2, 209-220. Voloche M, Ladisch MR, Rodwell VW, and Tsao GT. 1983. Reduction of acetoin to 2,3-butanediol in Klebsiella pneumonia: A new model. Biotech. Bioeng. 25, 173-183. Harwood HJ Jr, Brandt KG, and Rodwell VW. 1984. HMG-CoA reductase kinase: Purification and characterization of a protein kinase with an absolute requirement for ADP as an allosteric activator. J. Biol. Chem. 259, 2810-2815. Gill JF Jr, Beach MJ, and Rodwell VW. 1984. Transport of mevalonate by Pseudomonas sp. M. J. Bacteriol. 160, 294-298. Sherban DG, Kennelly PJ, Brandt KG, and Rodwell VW. 1985. Rat liver HMG-CoA reductase: Catalysis of the reverse reaction and two "half-reactions." J. Biol. Chem. 260, 12579- 12585. Gill JF Jr, Beach MJ, and Rodwell VW. 1985. Mevalonate utilization in Pseudomonas sp. M. Purification and characterization of an inducible 3-hydroxy-3-methylglutaryl coenzyme A reductase. J. Biol. Chem. 260, 9393-9398. Henneberg R, and Rodwell VW. 1985. Rapid modulation of rat hepatocyte HMG-CoA reductase activity by cAMP and cGMP. Physiol. Chem. Physics 17, 35-40. Scher DS, and Rodwell VW. 1989. 3-Hydroxy-3-methylglutaryl coenzyme A lyase from Pseudomonas mevalonii. Biochim. Biophys. Acta 1003, 321-326. Beach MJ, and Rodwell VW. 1989. Cloning, sequencing, and overexpression of mvaA, the gene that encodes 3-hydroxy-3-methylglutaryl coenzyme A reductase of Pseudomonas mevalonii. J. Bacteriol. 171, 2994-3001. Wang Y, Beach MJ, and Rodwell VW. 1989. HMG-CoA reductase, a product of the mva operon of Pseudomonas mevalonii, is regulated at the transcriptional level. J. Bacteriol. 171, 5567-5571. Jordan-Starck TC, and Rodwell VW. 1989. Pseudomonas mevalonii HMG-CoA reductase. Characterization and chemical modification. J. Biol. Chem. 264, 17913-17918. Jordan-Starck TC, and Rodwell VW. 1989. Role of cysteine residues in Pseudomonas mevalonii HMG-CoA reductase. Site-directed mutagenesis and characterization of the mutant enzymes. J. Biol. Chem. 264, 17919-17923. Anderson DH, and Rodwell VW. 1989. Nucleotide sequence and expression in Escherichia coli of the gene for HMG-CoA lyase from Pseudomonas mevalonii. J. Bacteriol. 171, 6468- 6472. Rodwell VW, Anderson DH, Beach MJ, Gill Jr JF, Jordan-Starck TC, Scher DS, and Wang Y. 1990. Organization and regulation of the mva operon in Pseudomonas mevalonii. In S. Silver, A. M. Chakrabarty, B. Iglewski, and S. Kaplan, "Pseudomonas: 6

Biotransformations, Pathogenesis and Evolving Technology." Amer. Soc. Microbiol., Washington, D.C., 151-158. Wang Y, Darnay BG, and Rodwell VW. 1990. Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J. Biol. Chem. 265, 21634-21641. Wrensford LV, Rodwell VW, and Anderson VE. 1991. 3-Hydroxy-3-methylglutaryldithio- coenzyme A: A potent inhibitor of Pseudomonas mevalonii HMG-CoA reductase. Biochem. Med. Metab. Biol. 45, 204-208. Wang Y, and Rodwell VW. 1991. Identification of a cis-acting regulatory element of the mvaA operon of Pseudomonas mevalonii. J. Bacteriol. 173, 3803-3806. Darnay BG, Wang Y, and Rodwell VW. 1992. Identification of the catalytically important histidine of 3-hydroxy-3-methylglutaryl-coezyme A reductase. J. Biol. Chem. 267, 15064- 15070. Bischoff KM, and Rodwell VW. 1992. Biosynthesis and isolation of (S)- and (R)-3-hydroxy- 3-methylglutaryl coenzyme A. Biochem. Med. Metab. Biol. 48, 149-158. Darnay BG, and Rodwell VW. 1993. Histidine865 is the catalytically important residue of Syrian hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase. J. Biol. Chem. 268, 8429- 8435. Darnay B. G, and M. Engel. An efficient method for pouring sequencing gels. Biotechniques 6, 144. Frimpong K, Darnay BG, and Rodwell VW. 1993. Syrian hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase expressed in Escherichia coli. Production of homogeneous protein. Protein Express. Purif. 4, 337-344. Frimpong K, and Rodwell VW. 1994. The active site of hamster 3-hydroxy-3-methylglutaryl- CoA reductase residues at the subunit interface and incorporates catalytically essential acidic residues from separate polypeptides. J. Biol. Chem. 269, 1217-1221. Omkumar RB, Darnay G, and Rodwell VW. 1994. Modulation of Syrian hamster 3-hydroxy- 3-methylglutaryl-CoA reductase activity by phosphorylation. Role of Serine 871. J. Biol. Chem. 269, 6810-6814. Omkumar R, and Rodwell VW. 1994. Phosphorylation of serine 871 impairs the function of histidine865 of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase. J. Biol. Chem. 269, 16862-16868. Lawrence CM, Chi Y-I, and Rodwell VW. 1995. Crystallization of HMG-CoA reductase from Pseudomanas mevalonii. Acta Cryst. D 51, 386-389. Lawrence MC, Rodwell VW, and Stauffacher CV. 1995. The crystal structure of Pseudomonas mevalonii HMG-CoA reductase at 3.0 Å resolution. Science 268, 1758-1762. Bischoff, KM, and Rodwell VW. 1996. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii. Purification, characterization, and overexpression. J. Bacteriol. 178, 19-23. Friesen JA, Lawrence CM, Stauffacher CV, and Rodwell VW. 1996. Structural determinants of nucleotide coenzyme specificity in the distinctive dinucleotide binding fold of HMG-CoA reductase from Pseudomonas mevalonii. Biochemistry 35, 11945-11950. Bischoff K, and Rodwell VW. 1997. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase of Haloferax volcanii: Role of histidine 398 and attenuation of activity by introduction of negative charge at position 404. Protein Science 6, 156-161. Friesen JA, and Rodwell VW. 1997. Identification of elements critical for phosphorylation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by adenosine monophosphate-activated protein kinase: Protein engineering of the naturally nonphosphorylatable 3-hydroxy-3- methylglutaryl coenzyme A reductase from Pseudomonas mevalonii. Biochemistry 36, 1157-1162. Friesen JA, and Rodwell VW. 1997. Protein engineering of the HMG-CoA reductase of Pseudomonas mevalonii. Construction of mutant enzymes whose activity is regulated by phosphorylation and dephosphorylation. Biochemistry 36, 2173-2177. 7

Bochar DA., Brown JR, Doolittle WF, Klenk HP, Lam W, Schenk ME, Stauffacher CV, and. Rodwell VW. 1997. 3-Hydroxy-3-methylglutaryl coenzyme A reductase of Sulfolobus solfataricus: DNA sequence, phylogeny, expression in E. coli of the hmgA gene, and purification and kinetic characterization of the gene product. J. Bacteriol. 179, 3632-3638. Rogers KS, Rodwell VW, and Geiger P. 1997. Active form of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase. Biochem. Mol. Med. 61, 114-120. Rosenthal RS, and Rodwell VW. 1998. Purification and characterization of the heteromeric transcriptional activator of the Pseudomonas mevalonii mvaAB operon. Protein Science 7, 178-184. Bochar DA, Friesen JA, Stauffacher CV, and Rodwell VW. 1999. Biosynthesis of mevalonic acid from acetyl-CoA. Ch. 2 in D. Cane (ed.), "Isoprenoids including carotenoids and steroids." Pergamon Press. Bochar DA, Stauffacher CV, and Rodwell VW. 1999. Sequence comparisons reveal two classes of HMG-CoA reductase. Mol. Genet. Metab. 66, 122-127. Bochar DA, Tabernero L, Stauffacher CV, and Rodwell VW. 1999. Aminoethylcysteine can replace the active site lysine of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase. Biochemistry 38, 8879-8883. Tabernero LD, Bochar A, Rodwell VW, and Stauffacher CV. 1999. Substrate-induced closure of the flap domain in the ternary complex structures provides new insights into the mechanism of catalysis by HMG-CoA reductase. Proc. Natl. Acad. Sci. U.S.A. 96, 7167- 7171. Bochar DA, Stauffacher CV, and Rodwell VW. 1999. Investigation of the conserved lysines of syrian hamster-3-hydroxy-3-methylglutaryl coenzyme A reductase. Biochemistry 38, 15848-15852. Kim, D-Y, Bochar DA, Stauffacher CV, and Rodwell VW. 1999. Expression and purification of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus. Protein Expression Purif. 17, 435-441. Kim D-Y, Stauffacher CV, and Rodwell VW. 2000. Engineering of Sulfolobus solfataricus HMG-CoA reductase to a form whose activity is regulated by phosphorylation and dephosphorylation. Biochemistry 39, 2269-2275. Kim D-Y, Tabernero LV, Rodwell W, and Stauffacher CV. 2000. Structure of HMG-CoA reductase with the cholesterol lowering agent Lovastatin. Biochemistry 39, 2269-2275 Kim D-Y, Stauffacher CV, and Rodwell VW. 2000. Dual coenzyme specificity of Archaeoglobus fulgidus HMG-CoA reductase. Protein Science 9, 1226-1234. Rodwell VC, Beach MJ, Bischoff KM, Bochar DA, Darnay BG, Friesen JA, Gill JF, Hedl M, Jordan-Starck T, Kennelly PJ, Kim D-Y. and Wang Y. 2000. 3-Hydroxy-3-methylglutaryl- CoA reductase in branched-chain amino acids in Methods in Enzymology (Eds. R. A. Harris and J. R. Sokatch) Vol. 324 pp. 259-280. Wilding E, Kim D-Y, Bryant AP, Gwynn MN, Lunsford RD, McDevitt D, Myers, Jr. JE, Rosenberg M, Sylvester D, Stauffacher CV, and Rodwell VW. 2000. Essentiality, expression and characterization of the Class II HMG-CoA reductase of Staphylococcus aureus. J. Bacteriol. 182, 5147-5152. Hedl M, Sutherlin A, Wilding EI, Mazzulla M, McDevitt D, Lane P, Burgner JW II, Lehnbeuter K, Stauffacher CV, Gwynn MN, Rodwell VW. 2002. Enterococcus faecalis acetoacetyl- coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis. J. Bacteriol. 184, 2116-2122. Sutherlin A, Hedl M, Sanchez-Neri B, Burgner II JW, Stauffacher CV and Rodwell VW. 2002. Enterococcus faecalis HMG-CoA synthase, an enzyme of isopentenyl diphospate biosynthesis. J. Bacteriol. 184, 4065-4070. Rodwell VW, Hedl M, Sutherlin A, Bochar DA, Stauffacher CV and Tabernero L. 2004. HMG-CoA Reductase. X-Pharm (web based). S. Enna and D. Bylund (Eds.), Elsevier Science, Inc. http://demo.xpharm.com/demo/neuro_editorial.htm Tabernero L, Rodwell VW and Stauffacher CV. 2003. Crystal structure of a statin bound to a class II HMG-CoA reductase. J. Biol. Chem. 278, 19933-19938. 8

Hedl M and Rodwell VW. 2004. Enterococcus faecalis mevalonate kinase. Protein Science 13, 687-693. Hedl M, Tabernero L, Stauffacher CV and Rodwell VW. 2004. Class II HMG-CoA reductases. J. Bacteriol. 186, 1927-1932. Hedl M and Rodwell VW. 2004. Inhibitions of the class II HMG-CoA reductase of Pseudomonas mevalonii. Protein Science 13, 1693-1697. Sutherlin A and Rodwell VW. 2004. Multienzyme Mevalonate Pathway Bioreactor. Biotech. Bioeng. 87, 546-551. Friesen JA and Rodwell VW. 2004. The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. Genome Biol. 5, 248-252. Doun SS, Burgner JW II, Briggs SD and Rodwell VW. 2005. Enterococcus faecalis phosphomevalonate kinase. Protein Sci. 14, 1134-1139. Steussy CN, Vartia AA, Burgner JW II, Sutherlin AL, Rodwell VW, and Stauffacher CV. 2005. X-Ray crystal structures of HMG-CoA synthase from Enterococcus faecalis and a complex with its second substrate/inhibitor Acetoacetyl-CoA. Biochemistry 44, 14256- 14267. Steussy CN, Robison AD, Tetric AM, Knight JT, Rodwell VW, Stauffacher CV, and Sutherlin AL. 2006. A structural limitation on enzyme activity: The case of HMG-CoA synthase. Biochemistry 45, 14407-14414.

Textbook

Co-author, Harper’s Illustrated Biochemistry, 9th-29th editions, 1960-present