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Curriculum Vitae V I C T O R W 2 CURRICULUM VITAE V I C T O R W. R O D W E L L E M E R I T U S P R O F E S S O R O F B I O C H E M I S T R Y Address: Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907-1153 Telephone: (765) 494-1608; FAX (765)494-7897 [email protected] Date of Birth: Sept. 10, 1929 Marital Status: Married Citizenship: U.S. Education 1947-51 B.S. Wilson Teachers College, Washington, DC - Chemistry 1951-52 M.S. George Washington U., Washington, DC - Biochemistry 1952-54 Univ. of Wisconsin, Madison, WI - Physiological Chemistry 1954-56 Ph.D. Univ. of Kansas, Lawrence, KS - Biochemistry 1956-58 Postdoc. Univ. of California, Berkeley, CA - Biochemistry Research and Professional Experience 2004-present Emeritus Professor, Biochemistry, Purdue University 1965-2004 Assoc. Prof. and Professor, Biochemistry, Purdue University 1958-65 Asst. Prof., Biochemistry, Univ. of California, San Francisco Medical Center 1956-58 USPHS Postdoctoral Fellow, Biochemistry, University of California, Berkeley 1951-56 Graduate Student, George Washington U., Univ. of Wisconsin, Univ. of Kansas Honors Helen Hay Whitney Foundation Predoctoral Fellow, Wisconsin (1952-54) USPHS Postdoctoral Fellow, Berkeley (1956-58) Purdue Alumni Association Helping Students Learn Award" (1984) Purdue Presidential Affirmative Action Award (1985) Purdue One Brick Higher Award (2003) Purdue School of Agriculture Outstanding Graduate Educator Award (2004) Publications Alpen EL, Mandel HG, Rodwell VW, and PK Smith. 1951. The metabolism of 14C carboxyl salicylic acid in the dog and in man. J. Pharm. Exp. Therap. 102, 150-155. Mandel HG, Smith PK, and Rodwell, VW. 1952. A study of metabolism of 14C salicylamide in the human. J. Pharm. Exp. Therap. 106, 433-439. Rodwell VW, Towne JC, and Grisolia S. 1956. Crystalline phosphoglyceric acid mutase. Biochim. Biophys. Acta 20, 394-396. Towne JC, Rodwell VW, and Grisolia S. 1957. The microestimation, distribution, and biosynthesis of 2,3-diphosphoglyceric acid. J. Biol. Chem. 226, 777-778. Rodwell VW, Towne JC, and Grisolia S. 1957. The kinetic properties of yeast and muscle phosphoglyceric acid mutase. J. Biol. Chem. 228, 875-890. 3 Edeloch H, Rodwell VW, and Grisolia S. 1957. The molecular properties of yeast and muscle phosphoglyceric acid mutase. J. Biol. Chem. 228, 891-903. Towne J, Rodwell VW, and Grisolia S. 1958. 2,3-Diphosphoglyceric acid. Biochem. Preps. 6, 12-15. Rodwell VW, Volcani BE, Ikawa M, and Snell EE. 1958. Bacterial oxidation of vitamin B6 I. Isopyridoxal and 5-pyridoxic acid. J. Biol. Chem. 233, 1548-1554. Berg RW, Rodwell VW, and Snell EE. 1958. Bacterial oxidation of vitamin B6. III. Metabolites of pyridoxamine. J. Biol. Chem. 235, 1555-1559. Ikawa M, Rodwell VW, and Snell EE. 1960. Bacterial oxidation of vitamin B6. II. Structure of "260 Compound". J. Biol. Chem. 235, 1164-1169. Mazumder RD, Sanadi R, and Rodwell VW. 1960. Purification and properties of hog kidney succinic thiokinase. J. Biol. Chem. 235, 2546-2550. Siddiqi MA, and Rodwell VW. 1962. Bacterial metabolism of mevalonic acid. Conversion to acetoacetate. Biochem. Biophys. Res. Commun. 8, 110-113. Rao DR, and Rodwell VW. 1962. Metabolism of pipecolic acid in a Pseudomonas species. I. -Aminoadipic and glutamic acids. J. Biol. Chem. 237, 2232-2238. Basso LV, Rao DR, and Rodwell VW. 1962. Metabolism of pipecolic acid in a Pseudomonas species. II. 1-Piperideine-6-carboxylic acid and -aminoadipic acid- -semialdehyde. J. Biol. Chem. 237, 2239-2245. Figmognari GM, and Rodwell VW. 1965. Cholesterol biosynthesis: Mevalonate synthesis inhibited by bile salts. Science 147, 1038. Figmognari GM, and Rodwell VW. 1965. Substrate-competitive inhibition of bacterial HMG-CoA reductase. Biochemistry 4, 2086-2090. Calvert AF, and Rodwell VW. 1966. Metabolism of pipecolic acid in a Pseudomonas species III. L- -Aminoadipate -semialdehyde:NAD+ oxidoreductase. J. Biol. Chem. 241, 409-414. Baginsky ML, and Rodwell VW. 1966. Metabolism of pipecolic acid in a Pseudomonas species IV. Electron transport particle of Pseudomonas putida. J. Bacteriol. 92, 424-432. Baginsky ML, and Rodwell VW. 1967. Metabolism of pipecolic acid in a Pseudomonas species V. Pipecolate oxidase and dehydrogenase. J. Bacteriol. 94, 1034-1039. Siddiqi MA, and Rodwell VW. 1967. Bacterial metabolism of mevalonic acid. J. Bacteriol. 93, 207-214. Reitz MS, and Rodwell VW. 1969. -Hydroxyglutarate oxidoreductase of Pseudomonas putida. J. Bacteriol. 100, 708-714. Reitz ML, Miller DL, and Rodwell VW. 1969. Synthesis of -aminovaleramide. Anal. Biochem. 28, 269-272. Shapiro DJ, Imblum RL, and Rodwell VW. 1969. Thin-layer chromatographic assay for HMG-CoA reductase and mevalonic acid. Anal. Biochem. 31, 383-390. Shapiro DJ, and Rodwell VW. 1969. Diurnal variation and cholesterol regulation of hepatic HMG-CoA reductase activity. Biochem. Biophys. Res. Commun. 37, 867-872. Fimognari GM, and Rodwell VW. 1970. Mevalonate biosynthesis in rat liver. Lipids 5, 104-108. McNamara DJ, Quackenbush FW, and Rodwell VW. 1970. Cycloheximide and chloramphenicol: Effects of rat liver acetate metabolism. Lipids 5, 146-148. Reitz ML, and Rodwell VW. 1970. -Aminovaleramidase of Pseudomonas putida. J. Biol. Chem. 245, 3091-3096. Bensch WR, and Rodwell VW. 1970. Purification and properties of HMG-CoA reductase from Pseudomonas. J. Biol. Chem. 245, 3755-3762. Miller DL, and Rodwell VW. 1971. Metabolism of basic amino acids in Pseudomonas putida. Properties of the inducible lysine transport system. J. Biol. Chem. 246, 1765-1771. Shapiro DJ, and Rodwell VW. 1971. Regulation of hepatic HMG-CoA reductase and cholesterol synthesis. J. Biol. Chem. 246, 3210-3216. Miller DL, and Rodwell VW. 1971. Metabolism of basic amino acids in Pseudomonas putida. Intermediates in L-arginine catabolism. J. Biol. Chem. 246, 5053-5058. 4 Hartline RA, and Rodwell VW. 1971. Metabolism of pipecolic acid in a Pseudomonas species. VI. Precursors of glutamate. Arch. Biochem. Biophys. 142, 32-39. Miller DL and Rodwell VW. 1971. Inactivation of L-lysine decarboxylase by L-lysine bromomethyl ketone. Biochem. Biophys. Res. Commun. 44, 1227-1233. Fan CL, Miller DL, and Rodwell VW. 1972. Metabolism of basic amino acids in Pseudomonas putida. Transport of lysine, arginine and ornithine. J. Biol. Chem. 247, 2283-2288. Chou C-S, and Rodwell VW. 1972. Metabolism of basic amino acid in Pseudomonas putida. -Guanidinobutyrate aminohydrolase. J. Biol. Chem. 247, 4486-4490. Jacobsen GB, and Rodwell VW. 1972. A Bacillus ribonucleic acid phosphodiesterase with associated 5'-nucleotidase activity. J. Biol. Chem. 247, 5811-5817. McNamara DJ, and Rodwell VW. 1972. Regulation of "Active isoprene" biosynthesis. In E. Kun and S. Grisolia (Eds.), Biochemical Regulatory Mechanisms in Eucaryotic Cells, Wiley, New York, pp. 205-243. Rodwell VW. 1972. Cholesterol regulation of hepatic HMG-CoA reductase. In J. Ganguly and R. M. S. Smellie (Eds.), Current Trends in the Biochemistry of Lipids, Academic Press, New York, pp. 295-301. Shapiro DJ, and Rodwell VW. 1972. Fine structure of the cyclic rhythm of HMG-CoA reductase: Differential effects of cholesterol feeding and fasting. Biochemistry 11, 1042-1045. McNamara DJ, Quackenbush FW, and Rodwell VW. 1972. Regulation of hepatic HMG-CoA reductase: Developmental pattern. J. Biol. Chem. 247, 5805-5810. Rodwell VW, McNamara DJ, and Shapiro DJ. 1973. Regulation of hepatic HMG-CoA reductase. Advan. Enzymol. 38, 373-412. Imblum RL, and Rodwell VW.1974. HMG-CoA reductase and mevalonate kinase of Neurospora crassa. J. Lipid Res. 15, 211-222. Shapiro DJ, Nordstrom JL, Mitschelen JJ, Rodwell VW, and Schimke RT. 1974. Micro assay for HMG-CoA reductase in rat liver and in L-cell fibroblasts. Biochem. Biophys. Acta 370, 369-377. McNamara DJ, and Rodwell VW. 1975. Regulation of hepatic HMG-CoA reductase: In vitro inhibition by a protein present in bile. Arch. Biochem. Biophys. 168, 378-385.. Fink DJ, and Rodwell VW. 1975. Kinetics of a hollow fiber dehydrogenase reactor. Biotech. Bioeng. 17, 1029-1050. Vanderbilt AS, Gaby NS, and Rodwell VW. 1975. Intermediates and enzymes between -ketoarginine and -guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida. J. Biol. Chem. 250, 5322-5329. Fan CL, and Rodwell VW. 1975. Physiological consequences of starvation in Pseudomonas putida: Degradation of intracellular protein and loss of activity of the inducible enzymes of L-arginine catabolism. J. Bacteriol. 124, 1302-1311. Brotherton JE, Emery A, and Rodwell VW. 1976. Characterization of sand as a support for immobilized enzymes. Biotech. Bioeng. 18, 527-543. Rodwell VW, Nordstrom JL, and Mitschelen JJ. 1976. Regulation of HMG-CoA reductase. Advan. Lipid Res. 14, 1-74. Young NL, and Rodwell VW. 1977. Regulation of HMG-CoA reductase in rat leukocytes. J. Lipid Res. 18, 572-581. Ladisch MR, Emery A, and Rodwell VW. 1977. Economic implications of purification of glucose isomerase prior to immobilization. Ind. Eng. Chem. Process Dev. 16, 309-313. Nordstrom JL, Mitschelen JJ, and Rodwell VW. 1977. Interconversion of active and inactive forms of rat liver HMG-CoA reductase. J. Biol. Chem. 252, 8924-8934. Keith ML, Rodwell VW, Rogers DH, and Rudney H. 1979. In vitro phosphorylation of HMG-CoA reductase: Analysis of 32P-labelled, inactivated enzyme. Biochem. Biophys. Res. Commun. 90, 969-975. Young NL, and Rodwell VW. 1980. Regulation of rat leukocyte HMG-CoA reductase: An application of quantitative TLC to a problem of clinical significance. In J. C. Touchstone and D. Rogers (Eds.), Thin-Layer Chromatography: Quantitative and Environmental Applications, Wiley, New York, pp. 426-441. 5 Brown WE, and Rodwell VW. 1980. HMG-CoA reductase (EC 1.1.1.34). In J. Jeffery (Ed.), Dehydrogenases Requiring Nicotinamide Coenzymes, Birkkhauser Verlag, Basel, Switzerland, pp. 232-272. Hunter CF, and Rodwell VW. 1980. Regulation of vertebrate liver HMG-CoA reductase via reversible modulation of its catalytic activity. J. Lipid Res. 21, 399-405. Brotherton JE, and Rodwell VW. 1980. Reversible inactivation of horse liver aldehyde dehydrogenase by 2-hydroxyethyl disulfide. Physiol. Chem. Physics 12, 483-495.
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