Contents Vol. 75, No. 1 January 1978 .1~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

V-iv INFORMATION TO CONTRIgUTORS I~~~~~~~~~~~~~~~~~~~~~~~~ v-vi AUTHOR INDEX Review 34-39 A. S. Monin On tome global problems of geophysical fluid dynamics (gravitational differentiation/rotational pole/mantle convection) :: .p Physic.] Sciences S. ASTRONOMY 1-3 L. H. Aller and S. J. Czyzak; j:~f1 Chemical composition of gaseous nebula NGC 6302 {planetary nebulae/spectrophotometry) CHEMISTRY 4-6 Tse-.4ok Ho and George A. Olah Silane/iodine-based cleavage of-esters and ethers under' neutral condiions (ester cleavage/ether cleavage/deakylaticn/ iodotrimethylsilane/phenyltrimethylsilane-iodine)

7-11 Gilda H. Loew and S. K. Burt., Energy conformation study of Met-enkephalin^,and its D-Ala2 analogue and their resemblance to rigid opiates (opiate-like peptid-es/tyramine overlap/low-energy conformer/induced fit) '12-18 ;.LinissPauling J ..Bond angles intransition-metal tricarbonyl compounds: A test of the theory-of hybrid bond orbitals (enneacovdlence/cobalt tricarbotyls/iro.ntricarbonyls/manganese tricarbonyls/chromium'tricarbonyls) , - 16-2d. RaymondM. Fuoss -' Paired ifs: DipQlar pairs as subset of.diffusion pairs (ion pairs/association constents/electrolyte models/conductakct4&ry) ;J S1 25 * .BriwazM. Hoffman and Quentin H. Gzbson On the phtpsensitivitNf liganded,lUemoproteinvand their metal-subs,tituted analogues(metallopor phyrin/quantw.yield/ftash , hotolysis) ;-

6-g29.4~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~N. Albeding, H. Frauenfierde, and P. Hainggi > .X .- Stochastic theoryof ligand migration in biomolecules (flash photolysi§/myogiobin kinetics)

Steven P. $chmidt, and Gary Biolumin peendeof the firefly: Key s irj the formation of the electronically excited state f6r model systps '. (chemilumic/elclrelectrontrarsfer/dioxetane/fluorscence) ,GE;OPXIYSICS

.+, ,p some g l of dynamics (A Review) pole/ ntle 34-89,.'^.~some A.Monlngl~b ysical (grapitotioenalantletdifferentiation/rotational co nvection) M.A'HEMATICS '40-42 R. William Gosper, Jr. : Decision procedure hypergeometric summation (algorithm/binomial coefficient forzn/symbolic' compntat:eLfor4,idefinitelinear recurrences)" identities/dlosed 4:03-4,. RonnieLee ..> unstable cohomology casses of SLn (Z) (stable cohomology/special linear groupieanniansrre compactification/dlgebraic K4theory) Biological Seiences BIOCHEMISTRY

45-49 Lawrence E. Shaplro, Herbert H. Samuels, and Barry M. Yaffe Thyroid and gtuweocorticoid hormones synergistically control growthhormone mRNA in cultured GH1 cells (L-triiodothyronine/ cortisol/wheat gem/cellTfree translation/multihormonal control) 50-5 3. Christopher P. GrayReinhold Sommer, Christine Polke, Ewald Beck, and Heinz Schalleri -''Str-u'ture of the origin ofDN4 replication of bacteriophiage fd (initiation of DNA replication/RNA-polymeraie biNding site/ nucldotide sequence/hairpin structures in single-strAnded DNA) .. 54-58 Lois E. Greene arn Evan Eisenberg Formation of a ternary complex: Actin, 5'-adenylyl imidodiphosphate, ahd thie subfragmefits of myosin (myosin subfragment 1/ heavy Meromyosin/association constqntq/tur.bidity) 59-63;. Charles Horfncy, Simeon Wrenn, and Edgar Haber.- Affinity purification ofcardiac adenykiate cyclase: Dependence on prior hyd'rophobic resolution (guanylyl nucleotides/adenosine j-tr iphosphate resins/detergent solubilization/hydrophobic chromatography) 64-68 Gary J. Quigley, iartha M. Teeter, and Alexander Rich Structural analysis of spernxine and magnesium ion binding to yeast phepylalanine transfer RNA (molecular refinernent/hydrogeln bonding/polynucleotide folding) (Continued on inside back cover) Contents (Continued from outside back cover)

69-73 Richard Condit, Alison Cowie, Robert Kamen, and Mike Fried Transcription of a defective polyoma virus genome (viral transcription complexes/RNA-DNA hybridization) 74-78 W. Friso Van Voorthuizen, Christiane Dinsart, Richard A. Flavell, Jan J. M. De Vijlder, and Gilbert Vassart Abnormal cellular localization of thyroglobulin mRNA associated with hereditary congenital goiter and thyroglobulin deficiency (complementary DNAIpolysomes/gene expression/DNA-RNA hybridizations) 79-83 Brian S. Schaffhausen, Jonathan E. Silver, and Thomas L. Benjamin Tumor antigen(s) in cells productively infected by wild-type polyoma virus and mutant NG-18 (papovavirus/hr-t deletion! nontransforming mutant) 84-88 James R. Rasmussen and Jack L. Strominger Utilization ofa depsipeptide substrate for trapping acyl-enzyme intermediates of penicillin-sensitive D-alanine carboxypeptidases (esterase activity/rate acceleration/penicillin binding site) 89-93 George M. McCorkle, Timothy D. Leathers, and H. E. Umbarger Physical organization of the ilvEDAC genes of Escherichia coli strain K-12 (isoleucine and valine biosynthesis/restriction endonuclease mapping/heteroduplex analysis/gene expression) 94-98 Richard D Palmiter, Jean Gagnon, and Kenneth A. Walsh Ovalbumin: A secreted protein without a transient hydrophobic leader sequence ("signal hypothesis"/acetylation/NH2-terminal sequence/cell-free translation) 99-102 Mario Ascoli and David Puett Gonadotropin binding and stimulation of steroidogenesis in Leydig tumor cells (choriogonadotropin/hormone action/testicular tumor) 103-107 Joel L. Sussman and Edward N. Trifonov Possibility of nonkinked packing of DNA in chromatin (chromatin structure/DNA kinking/smooth DNA deformation) . 108-112 Rob Benne, Jeffrey Edman, Robert R. Traut, and John W. B. Hershey Phosphorylation of eukaryotic protein synthesis initiation factors (translational control/rabbit reticulocytes/cyclic AMP- independent kinase/in vitro phosphorylation/intracellular phosphorylation) 113-116 J. Myron Hood, Audree V. Fowler, and Irviig Zabin On the evolution of,-galactosidase (amino acid sequence/lac operon/dihydrofolate reductase) 117-121 L. V. Crawford, C. N. Cole, A. E. Smith, E. Paucha, P. Tegtmeyer, K. Rundell, and P. Berg Organization and expression of early genes of simian virus 40 (early deletion mutants/large-T and small-t polypeptides/spliced large-T mRNA) 122-126 Konrad Sandhoff and Bernhard Pallmann Membrane-bound neuraminidase from calf brain: Regulation of oligosialoganglioside degradation by membrane fluidity and membrane components (lipophilic and hydrophilic substrates/inhibitors/general anesthetics/fluorescence depolarization) 127-130 Nancy Lee, Carl Scandella, and Masayori Inouye Spin labeling of a cysteine residue of the Escherichia coli outer membrane lipoprotein in its membrane environment (electron spin resonance/peptidoglycan/lipoprotein mutant) 131-135 Costa P. Georgopoulos and Barbara Hohn Identification of a host protein necessary for bacteriophage morphogenesis (the groE gene product) (transducing bacteriophage X/sodium dodecyl sulfate gel electrophoresis/in vitro recombination) 136-139 Roger W. Hendrix and Lapchee Tsui Role of the host in virus assembly: Cloning of the Escherichia coli groE gene and identification of its protein product (transducing phage/in vitro recombination)

140-144 Michael D. Roper and Wesley D. Wicks --- Evidence for acceleration of the rate of elongation of tyrosine aminotransferase nascent chains by dibutyryl cyclic AMP (ribosomal transit time/H35 hepatoma cells/dexamethasone) 145-148 Kurt Pfister, Jeremias H. R. Kdgi, and Philipp Christen Syncatalytic conformational changes in aspartate aminotransferase determined by hydrogen-deuterium exchange (mechanism of enzyme action/transamination/pyridoxal 5'-phosphate/enzyme flexibility/free energy transduction in enzymes) 149-152 Richard F. Parrish, J. William Straus, Kenneth L. Polakoski, and Frederick A. Dombrose Phospholipid vesicle stimulation of proacrosin activation (acrosin/spermatozoa/lipid-protein interaction) 153-157 Santanu Dasgupta and Sankar Mitra Structure of nascent replicative form DNA of coliphage M13 (strain polA480ex/ribonucleotides/gaps) 158-161 K. A. Jacobs, V. Shen, and D. Schlessinger Coupling of lac mRNA transcription to translation in Escherichia coli cell extracts (in vitro protein synthesis/Ngene mRNA/ calcium ions/lac operon/coupling) 162-166 Eiichi Soeda, Genki Kimura, and Kin-ichiro Miura Similarity of nucleotide sequences around the origin of DNA replication in mouse polyoma virus and simian virus 40 (DNA sequencing/bacteriophage T4 DNA polymerase/DNA tumor virus) 167-171 Chung Shing Chen and Tokumasa Nakamoto Translational specificity of Bacillus stearothermophilus ribosomes (initiation/secondary structure/ribosomal affinity/mRNA site selection) 172-174 P. W. Riddles, J. de Jersey, and B. Zerner Absence of evidence for an intermediate in the deacetylation of acetylchymotrypsin (enzyme kinetics/acyl-enzyme mechanism) (Continued on page x) Contents (Continued from inside back cover)

175-179 F. Ben-Hamida and G. Beaud In vitro inhibition of protein synthesis by purified cores from vaccinia virus (reticulocyte lysate/host cell shutoff/polypeptide chain initiation block) 180-184 T. L. Blundell, S. Bedarkar, E. Rinderknecht, and R. E. Humbel Insulin-like growth factor: A model for tertiary structure accounting for its immunoreactivity and receptor binding (nonsuppressible insulin-like activity/molecular model building/evolution of insulin/amino acid sequence homology/ quaternary structure) 185-189 Walter Goodman, David A. Schooley, and Lawrence I. Gilbert Specificity of the juvenile hormone binding protein: The geometrical isomers ofjuvenile hormone I (racemates/insect hormone/ high-resolation liquid chromatography/binding site) 190-194 Pablo Valenzuela, Alejandro Venegas, Fanyela Weinberg, Robert Bishop, and William J. Rutter Structure of yeast phenylalanine-tRNA genes: An intervening DNA segment within the region coding for the tRNA (gene regulation/DNA sequence/tRNA processing) 195-199 M. Hogan, N. Dattagupta, and D. M. Crothers Transient electric dichroism of rod-like DNA molecules (restriction fragments/DNA structure/rotational relaxation/anisotropic ion flow) 200-203 Mildred Cohn and Angela Hu Isotopic (180) shift in 31p nuclear magnetic resonance applied to a study of enzyme-catalyzed phosphate-phosphate exchange and phosphate (oxygen)-water exchange reactions (ADP-Pi exchange/polynucleotide phosphorylase/site of bond cleavage/inorganic pyrophosphatase/oxygen scrambling) 204-208 Hans Trachsel and Theophil Staehelin Binding and release of eukaryotic initiation factor eIF-2 and GTP during protein synthesis initiation (phosphorylation of Met- tRNAf binding factor/GTP hydrolysis/protein synthesis control) 209-213 Raymond Kaempfer, Rivka Hollender, William R. Abrams, and Ruth Israeli Specific binding of messenger RNA and methionyl-tRNAfmet by the same initiation factor for eukaryotic protein synthesis (eukaryotic initiation factor 2/RNA affinity chromatography/mRNA-cellulose/double-stranded RNA/negative- strand RNA) 214-217 K. A. Chandrabose, E. G. Lapetina, C. J. Schmitges, M. I. Segel, and P. Cuatrecasas Action of corticosteroids in regulation of prostaglandin biosynthesis in cultured fibroblasts (cyclo-oxygenase/prostacyclin/anti- inflammation/virus transformation/lipoxygenase) 218-222 William A. Catterall and Cynthia S. Morrow Binding of saxitoxin to electrically excitable neuroblastoma cells (ion transport/scorpion toxin/batrachotoxin) 223-227 David J. M. Fuller, Craig V. Byus, and Diane Haddock Russell Specific regulation by steroid hormones of the amount of type I cyclic AMP-dependent protein kinase holoenzyme (castration/ hypophysectomy/adrenalectomy/prostrate/testosterone maintenance) 228-232 Lee E. Limbird and Robert J. Lefkowitz Agonist-induced increase in apparent ,B-adrenergic receptor size (hormone receptor/adenylate cyclase/ligand-induced molecular interconversions/guanine nucleotides) 233-237 Bik-Kwoon Tye, Janice Chien, I. R. Lehman, Bruce K. Duncan, and Huber R. Warner Uracil incorporation: A source of pulse-labeled DNA fragments in the replication of the Escherichia coli chromosome (Okazaki fragments/dUTPase/uracil N-glycosidase/discontinuous DNA replication) 238-242 Baldomero M. Olivera DNA intermediates at the Escherichia coli replication fork: Effect of dUTP (cellophane disc system/asymmetric DNA synthesis/ Okazaki pieces/uracil excision) 243-247 Cesar DeHaro, Asis Datta, and Severo Ochoa Mode of action of the hemin-controlled inhibitor of protein synthesis (protein phosphorylation/initiation factor eIF-2 kinase/ initiation factor-eIF-2 stimulating protein/ternary complex formation/40S ribosomal complex formation) - 248-251 James L. Maller, Bruce E. Kemp, and Edwin G. Krebs In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP-dependent protein kinase (Xenopus oocytes/ microinjection/protein phosphorylation/peptides) 252-255 N. Ramachandran and Roberta F. Colman Evidence for the presence of two nonidentical subunits in NAD-dependent isocitrate dehydrogenase (acrylamide gel electrophoresis/NH2-terminal amino acids/tryptic map) 256-260 Ian M. Kerr and Ronald E. Brown pppA2'p5'A2'p5'A: An inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells (cell-free systems/double-stranded RNA/low molecular weight inhibitor/oligomeric series/protein kinase) 261-265 Rockford K. Draper, Daniel Chin, and Melvin I. Simon - Diphtheria toxin has the properties of a lectin [concanavalin A/wheat germ agglutinin/cell surface receptors/ovalbumin (oligosaccharides) glycopeptide/cytotoxicity] 266-269 S. Ulitzur and J. W. Hastings Myristic acid stimulation of bacterial bioluminescence in "aldehyde" mutants (fatty acids/bacterial luminescence/Beneckea harveyi/Photobacterium fischeri) 270-274 M. D. Cole, M. Beer, Th. Koller, W. A. Strycharz, and M. Nomura Electron microscopic determination of the binding sites of ribosomal proteins S4 and S8 on 16S RNA (ribosomal protein-rRNA complex/formaldehyde fixation and denaturation) (Continued on page ix) x Contents (Continued from page x)

275-279 Phang-C. Tai, Brian J. Wallace, and Bernard D. Davis Streptomycin causes misreading of natural messenger by interacting with ribosomes after initiation (protein synthesis/phenotypic suppression/temperature-sensitive aminoacyl-tRNA synthetase/phage R17RNA translation/aminoglycosides) 280-284 Paul C. Ztamecnik and Mary L. Stephenson Inhibition ofRous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide (tridecamer deoxyribonucleotide/hybridization competitor/hybridon) 285-288 Mary L. Stephenson and Paul C. Zamecnik Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide (in vitro protein synthesis/nucleic acid hybridization/DNA nucleotidyltransferase) 289-293 Kathleen A. Presper, Manju Basu, and Subhash Basu Biosynthesis in vitro of fucose-cortaining glycosphingolipids in human neuroblastoma IMR-32 cells (5'-bromodeoxyuridine/blood group active glycosphingolipids/fucosyltransferases/galactosyltransferases) 294-297 Leonard P. Guarente and Jon Beckwith Mutant RNA polymnerase of Escherichia coli terminates transcription in strains making defective rho factor (rifampicin-resistant mutation/trp termination/rho mutations) BIOPHYSICS 298-302 J. F. Nagle and H. J. Morowitz Molecular mechanisms for proton transport in membranes (proton pump/molecular motor/praton wire/hydrogen-bonde'd chains) 303-307 Jonathan Greer and Bruce L. Bush Macromolecular shape and surface maps by solvent exclusion (molecular shape specificity/solvent accessibility/hydrophobic interactions/protein quaternary structure) 308-310 C. Huang and J. T. Mason Geometric packing constraints in egg phosphatidylcholine vesicles (inner and outer monolayers of vesicle bilayers/transmembrane asymmetry) 311-314 Roland Valdes, Jr. and Gary K. Ackers Self-association of hemoglobin ASH chains is linked to oxygenation (protein association/ligand binding/thermodynamics/ equilibrium gel permeation) 315-318 Stephen Bone, T. John Lewis, Ronald Pethig, and Albert Szent-Gydrgyi Electronic properties of some protein-methylglyoxal complexes (semiconductivity/electron spin resonance/permittivity/dielectric dispersion) CELL BIOLOGY 319-323 Kamalendu Nath, Jerry W. Shay, and Arthur'P. Bollon Relationship between dibutyryl cyclic AMP and microtubule organization in contracting heart muscle cells (primary myocyte cultures/inte'rcellular communication/cytoskeleton/colchicine) 324-328 Terry Lichtor and Godfrey S. Getz Cytoplasmic inheritance of rutamycin resistance in mouse fibroblasts (mitochondria/enucleation/cell fusion/somatic cell genetics) 329-333 Shin Lin, Diane Chang Lin, and Michael D. Flanagan Specificity of the effects of cytochalasin B on transport and motile processes (sugar transport/thymidine transport/ dihydrocytochalasin B/cell motility and morphology/cytochalasin B receptors) 334-338 Barry S. Eckert and Judith A. Snyder Combined immunofluorescence and high-voltage electron microscopy of cultured mammalian cells, using an antibody that binds to glutaraldehyde-treated tubulin (glutaraldehyde fixation/microtubules/affinity chromatography) 339-341 Robert W. Holley, Rosemary Armour, and Julia H. Baldwin Density-dependent regulation of growth of BSC-1 cells in cell culture: Control of growth by low molecular weight nutrients (epithelial cells/glucose/glutamine/initiation of DNA synthesis/wound healing experiment) 342-345 Maureen Gilmore-Hebert and Randolph Wall Immunoglobulin light chain mRNA is processed from large nuclear RNA (precursors to K mRNA/post-transcriptional cleavage/ recombinant DNA probes) 346-350 Alain R. Sarasin and Philip C. Hanawalt Carcinogens enhance survival of UV-irradiated simian virus 40 in treated monkey kidney cells: Induction of a recovery pathway? (chemical carcinogen/inducible DNA repair/UV-reactivation/carcinogen-reactivation) 351-355 John J. Castellot, Jr., Michael R. Miller, and Arthur B. Pardee Animal cells reversibly permeable to small molecules (DNA synthesis/ribonucleotide reductase/hydroxyurea/cytosine arabinosides/baby hamster kidney cells) 356-360 I. Vlodavsky, P. E. Fielding, C. J. Fielding, and D. Gospodarowicz Role of contact inhibition in the regulation of receptor-mediated uptake of low density lipoprotein in cultured vascular endothelial cells (membrane fluidity/vascular endothelium/wounding) '-361-365 Chung Nan Chang, Gunter Blobel, and Peter Model Detection of prokaryotic signal peptidase in an Escherichia coli membrane fraction: Endoproteolytic cleavage of nascent fl pre- coat protein (bacteriophage fl DNA/coupled transcription-translation system/cotrans'lational cleavage/amino- terminal sequencing of cleavage products/signal hypothesis) (Continued on page viii) ix Contents (Continued from page ix)

366-370 James Kamine, John G. Burr, and John M. Buchanan Multiple forms of sarc gene proteins from Rous sarcoma virus RNA (cell-free translation/peptide maps/two-dimensional electrophoresis/reticulocyte lysate) 371-375 Friedrich Grummt Diadenosine 5',5"'-P1,P4-tetraphosphate triggers initiation of in vitro DNA replication in baby hamster kidney cells (growth regulation/cell cycle/signal nucleotides/pleiotypic control/electron microscopy) DEVELOPMENTAL BIOLOGY 376-380 Uwe Deppe, Einhard Schierenberg, Thomas Cole, Christian Krieg, David Schmitt, Bonita Yoder, and Gunter von Ehrenstein Cell lineages of the embryo of the nematode Caenorhabditis elegans (metazoan model organism/determinate cleavage/stem cell autonomy/cell division synchrony/cell cycle clocks) ECOLOGY 381-384 Robin L. Vannote A geometric model describing a quasi-equilibrium of energy flow in populations of stream insects (growth/metabolism/ bioenergeties/temperature/Ephemeroptera) EVOLUTION 385-389 P. J. Darlington, Jr. Altruism: Its characteristics and evolution (set and group selection/kin selection/human evolution) GENETICS 390-394 Jerome C. Regier, Fotis C. Kafatos, Robert Goodfliesh, and Leroy.Hood Silkmoth chorion proteins: Sequence analysis of the products of a multigene family (protein sequences/protein homology) 395-399 George B. Johnson Structural flexibility of isozyme variants: Genetic variants in Drosophila disguised by cofactor and subunit binding (electrophoresis/polymorphism/alcohol dehydrogenase/NAD) 400-404 David Shore, Giovanni Dehd, Judith Tsipis, and Richard Goldstein Determination of capsid size by satellite bacteriophage P4 [helper-satellite virus interaction/morphogenesis/sid (size determination) mutant/capsidful of DNA/heterozygous diploid phage] 405-409 C. James Ingles Temperature-sensitive RNA polymerase II mutations in Chinese hamster ovary cells (a-amanitin resistance/nitrosoguanidine mutagenesis/cell hybridization/reversion/RNA nucleotidyltransferase) 410-414 Thomas R. Skopek, Howard L. Liber, John J. Krolewski, and William G. Thilly Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker (genetic toxicology/mutagenesis/screening assay) 415-419 Tsuyoshi Kakefuda and Hiro-aki Yamamoto Modification of DNA by benzo[ajpyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (ultimate carcinogen/binding and modification of DNA/stepwise digestion with endonuclease Si and DNase/DNA base analysis) 420-422 Shozo Yokoyama and Joseph Felsenstein A model of kin selection for an altruistic trait considered as a quantitative character (altruism/quantitative genetics/evolution/ animal behavior) 423-426 Thomas Nagylaki Random genetic drift in a dine (population genetics/selection/migration) 427-431 Carol Gross, John Hoffmann, Cathy Ward, Dayle Hager, Greg Burdick, Hillard Berger, and Richard Burgess Mutation affecting thermostability of sigma subunit of Escherichia coli RNA polymerase lies near the dnaG locus at about 66 min on the E. coli genetic map (transcription/rpoDl/RNA nucleotidyltransferase) IMMUNOLOGY 432-435 J. C. Cambier, F. S. Ligler, J. W. Uhr, J. R. Kettman, and E. S. Vitetta Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD (receptor IgD/B cells) 436-440 Karl Erik Hellstr6m and Ingegerd Hellstrom Evidence that tumor antigens enhance tumor growth in vivo by interacting with a radiosensitive (suppressor?) cell population (tumor immunity/blocking factors/Winn assays/immunological enhancement) 441-445 John H. Russell, Arthur H. Hale, Leo C. Ginns, and Herman N. Eisen Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes (major histocompatibility complex/H-2 restriction/cell surface antigens/mouse plasmacytomas) 446-450 William P. Schrader, Bernard Pollara, and Hilaire J. Meuwissen Characterization of the residual adenosine deaminating activity in thespleen of a patient with combined immunodeficiency disease and adenosine deaminase deficiency (enzyme deficiency) (Continued on page vii)

viii Contents (Continued from page viii)

MEDICAL SCIENCES 451-453 Reinhart Nissen, George J. Cardinale, and Sidney Udenfriend Increased turnover of arterial collagen in hypertensive rats (hydroxyproline) 454-458 William S. M. Wold, Jesse K. Mackey, Karl H. Brackmann, Nobuyuki Takemori, Patricia Rigden, and Maurice Green Analysis of human tumors and human malignant cell lines for BK virus-specific DNA sequences (molecular hybridization/BK virus-transformed hamster cells/human cancer) 459-463 Roderick M. Farb, Robert Dykes, and Gerald S. Lazarus Anti-epidermal-cell-surface pemphigus antibody detaches viable epidermal cells from culture plates by activation of proteinase (epithelial cell/concanavalin A/acantholysis) 464-467 E. S. Garnett, G. Firnau, P. K. H. Chan, S. Sood, and L. W. Belbeck ['8F]Fluoro-dopa, an analogue of dopa, and its use in direct external measurements of storage, degradation, and turnover of intracerebral dopamine (Parkinson disease/schizophrenia) 468-471 Kenneth S. Korach, Manfred Metzler, and John A. McLachlan Estrogenic activity in vivo and in vitro of some diethylstilbestrol metabolites and analogs (diethylstilbestrol metabolism/estrogen receptor/mouse uterus/hormonal toxicity/structure-activity) 472-476 Amos Cohen, Rochelle Hirschhorn, Sheldon D. Horowitz, Arieh Rubinstein, Stephen H. Polmar, Richard Hong, and David W. Martin, Jr. Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency (enzyme deficiency/ immunodeficiency) 477-481 David A. York, George A. Bray, and Yaichiro Yukimura An enzymatic defect in the obese (ob/ob) mouse: Loss of thyroid-induced sodium- and potassium-dependent adenosinetriphosphatase (obesity/genetic/hyperthyroid/thermogenesis) 482-485 Richard C. K. Yen, William B. Adams, Cheri Lazar, and Michael A. Becker Evidence for X-linkage of human phosphoribosylpyrophosphate synthetase (genetic mapping/dosage compensation) 486-489 Eugene Straus and Rosalyn S. Yalow Species specificity of cholecystokinin in gut and brain of several mammalian species (neuropeptides/gastrointestinal peptides/ radioimmunoassay/antibody specificity/tryptic conversion) 490-494 Samuel Hellman, Leslie E. Botnick, Eileen C. Hannon, and Roy M. Vigneulle Proliferative capacity of murine hematopoietic stem cells (serial transplantation/alkylating agents) MICROBIOLOGY 495-499 Jean Rommelaere, Douglas V. Faller, and Nancy Hopkins Characterization and mapping of RNase Ti-resistant oligonucleotides derived from the genomes of Akv and MCF murine leukemia viruses (recombination) NEUROBIOLOGY 500-504 H. Benjamin Peng and Yasuko Nakajima Membrane particle aggregates in innervated and noninnervated cultures of Xenopus embryonic muscle cells (synaptogenesis/ freeze-fracture/electron microscopy) 505-509 Timothy Lorenz and Mark Willard Subcellular fractionation of intra-axonally transported polypeptides in the rabbit visual system (NaDodSO4-polyacrylamide gel electrophoresis/autoradiography/mitochondria/plasma membrane) 510-514 Andre Sobel, Thierry Heidmann, John Hofler, and Jean-Pierre Changeux Distinct protein components from Torpedo marmorata membranes carry the acetylcholine receptor site and the binding site for local anesthetics and histrionicotoxin (acetylcholine ionophore/quinacrine fluorescence/subunit interactions) 515-519 Yuh Nung Jan and Lily Yeh Jan Genetic dissection of short-term and long-term facilitation at the Drosophila neuromuscular junction (synaptic efficacy/ neurological mutant) 520-523 S. M. Schuetze, E. F. Frank, and G. D. Fischbach Channel open time and metabolic stability of synaptic and extrasynaptic acetylcholine receptors on cultured chick myotubes (noise analysis/receptor turnover/synapse formation) 524-528 P. Robberecht, M. Deschodt-Lanckman, and J. J. Vanderhaeghen Demonstration of biological activity of brain gastrin-like peptidic material in the human: Its relationship with the COOH-terminal octapeptide of cholecystokinin (neuropeptides/gastrointestinal peptides/pancreatic amylase and adenylate cyclase/ caerulein binding/size and charge discrimination) PHYSIOLOGICAL SCIENCES 529-530 Ernest Glen Wever Sound transmission in the salamander ear (hearing/cochlear potentials/amphibia) 531-534 Yoshisuke Ozaki, Richard J. Wurtman, Rafael Alonso, and Harry J. Lynch Melatonin secretion decreases during the proestrous stage of the rat estrous cycle (norepinephrine/rhythms/chromatography/ radioimmunoassay)

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