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Abstractbandbstractband DEUTSCHE GESELLSCHAFT FÜR DGP PATHOLOGIE E.V. GOES Start 4. Juni 2020 Seit 1897 – dem Leben verpflichtet DIGITAL On-demand bis 6. September 2020 104. Jahrestagung der Deutschen Gesellschaft für Pathologie Unser Immunsystem – der Staat im Staate Joaquín Sorolla Bastida. | Una investigación o El Dr. Simarro en el Laboratorio, 1897. en el Laboratorio, Simarro o El Dr. | Una investigación Bastida. Joaquín Sorolla 00417. nº inv. | Museo Sorolla, lienzo. Óleo sobre AABSTRACTBANDBSTRACTBAND www.pathologie-kongress.com Abstractband 104. Jahrestagung der Deutschen Gesellschaft für Pathologie e.V. 4. Juni – 6. September 2020 „DGP goes digital“ Schwerpunkte der Jahrestagung ▪ Immunpathologie: Autoimmunität, Immundefizienz, Immunonkologie, intratumorale Immunreaktion, basic science ▪ Personalisierte Medizin ▪ Digitale Pathologie und Informatik in der Pathologie ▪ „A case I will never forget“ Vorsitzender der Gesellschaft Prof. Dr. med. Gustavo Baretton, Dresden Tagungspräsident Prof. Dr. med. Peter Möller, Ulm Herausgeberin, Lektorat und Copyright Deutsche Gesellschaft für Pathologie e.V. Geschäftsstelle Robert-Koch-Platz 9 10115 Berlin [email protected] Tagungsorganisation MCI Berlin [email protected] Berlin, September 2020 Inhaltsverzeichnis (Klicken Sie auf den Beitragstitel, um direkt zum ausgewählten Abstract zu gelangen.) KN Keynote Lecture: H. Rodewald (Heidelberg).................................................................................... 15 Deconvolution of hematopoiesis by fate mapping, barcoding and single cell transcriptomics DGP01 Immunpathologie I - Orthologie und Defizienz des Immunsystems ..................................... 16 The Gut: Center of Immunity- Rare inflammatory bowel diseases caused by immunodeficiencies Accelerated partial breast irradiation: Macrophage polarisation shift classification identifies high-risk tumours in early hormone receptor-positive breast cancer The Immune System of Adipose Tissue - Obesity-Associated Inflammation The thymoproteasome: a specialized form of proteasomes involved in thymic development of CD8+ T cells DGP02 Immunpathologie II - Umwelt- und Autoimmunität ................................................................. 19 Persistent T-cell-receptor beta clonotypes in refractory Coeliac Disease are stimulated by common antigens. Autoimmune enteropathy of the adult - a rare and difficult, but important differential diagnosis of chronic diarrhea Inhibition of canonical IKK/ NF-κB signaling in pancreatic stellate cells promotes development of autoimmune pancreatitis in mice Comparative analysis of the immune microenvironment in usual interstitial pneumonia and organizing pneumonia. The complement system - a hot topic not only in renal medicine DGP03 Immunpathologie III - Varia ........................................................................................................ 25 The ambiguous role of the inflammatory micromileu in solid tumors Tumour Infiltrating Lymphocytes Assessed on Haematoxylin Eosin Stained Pre-Treatment Biopsies of Oesophageal Cancer Patients Predict Benefit from Chemotherapy - Results from the UK MRC OE02 Trial Interspatial distribution of tumor and immune cells in correlation with PD-L1 in molecular subtypes of gastric cancers Phenotype, clinical relevance, and therapeutic modulation of infiltrating plasmacytoid dendritic cells in colorectal cancer Inter- and Intra-tumor Heterogeneity of the Tumor Microenvironment in Pulmonary Adenocarcinoma DGP04 A case I will never forget - on demand ..................................................................................... 30 Multiple HPV-Infections in a Deep-Seated Rectal Polyp and Perianal Condylomata Acuminata An infraorbital tumor in a 75 years old male patient CIC fusion-positive sarcoma of the spermatic cord 1 DGP05 Immunonkologie II ...................................................................................................................... 33 Categorizing Immune Cell Infiltrate of HNSCC as “hot”, “cold” or “excluded” allows prediction of overall survival CDK12 expression profile and correlation with tumor associated immune cell infiltrates in prostate cancer Tumor-microenvironment interactions in classical Hodgkin lymphoma: pathogenetic mechanisms and prognostic relevance Migration properties distinguish tumor cells of classical Hodgkin lymphoma from anaplastic large cell lymphoma cells Analysis of the microenvironment of follicular lymphoma by gene expression analysis: importance of the Th17 axis Immune cell repertoire and immune dysregulation in myelodysplastic diseases DGP06 Immunonkologie I ....................................................................................................................... 40 The role of iNKT cells for immune tolerance and tumor control Epitope quality: Changes in tumor antigen processing are leading to an immune escape. Metabolic Derangements in Colorectal Cancer Cells Induce Anti-Tumor Immunity DGP07 Immunonkologie III ..................................................................................................................... 44 High Numbers and Densities of PD1+ Germinal Center Cells in Tumor Draining Lymph Nodes of Triple Negative Breast Cancer are Associated with Lower Survival Rates Cancer testis antigens and immunotherapy: Expression of the cancer testis antigens (CTAs) PRAME, NY-ESO-1 and SSX2 in soft tissue tumors Gene expression profiling to predict long-term benefit from immune checkpoint blockade in lung cancer Assessment of PD-L1 expression in malignant salivary gland tumors by the use of established scoring criteria: tumor proportion score (TPS), combined positivity score (CPS) and immune cell (IC) infiltrate Prediction of anti-PD-1 immunotherapy response in cutaneous T cell lymphoma by highly multiplexed tissue imaging Heterogeneity of and survival prediction according to PDL1 expression in 125 lymph node positive bladder cancer patients treated surgically with curative intent The quantity of intra- and peritumoral immune cell infiltrate varies depending on the PD-L1 status in advanced bladder cancer: A comparative study of the intra- and peritumoral immunarchitecture. DGP08 Bewerbungen Promotionspreis - on demand .......................................................................... 53 The Characterisation of wtVHL Clear Cell Renal Cell Carcinoma Incidences of MYD88, CD79B, CARD11, and BTK Somatic Mutations Discriminates Large Cell Variant of Gastric Marginal Zone B-Cell Lymphoma (MZBL) from Nodal and Extranodal DLBCL An AI-based prostate diagnostic tool demonstrates high performance and identifies missed prostate cancers in France’s largest network of pathology institutes Reduced miR-196a expression enhances the sensitivity towards HOX/PBX complex inhibition by small peptides in cell lines derived from recurrent chordomas Biomarker profiles predicting a higher risk for lung metastasis in colorectal cancer 2 Proteomics uncover EphA2 overexpression in cetuximab resistant colorectal cancer cell lines as a potential novel therapeutic target Tumor-associated macrophages in classical Hodgkin lymphoma: hormetic relationship to outcome DGP09 Rising Stars - Rudolf-Virchow-Preisträger und aktuelle Habilitationen................................ 61 Histomorphological and molecularpathological prognostic factors in colorectal cancer Intratumoral heterogeneity of gastric cancer and its impact on the validation of prognostic and predictive biomarkers Predicting response and outcome after chemotherapy and new, targeted approaches in malignant pleural mesothelioma Metabolic and molecular alterations in preneoplastic clear cell lesions of the liver and the kidney in experimental and human carcinogenesis KOOP02 Hungarian-German Workshop 2020 - virtuelle Sitzung ...................................................... 66 Prehabilitation in ALPPS induced liver regeneration: insight into the molecular mechanisms and quick fix of mitochondrial dysfunction The prognostic role of HER2 gene copy number variations in immunohistochemistry-equivocal (2+) invasive breast cancer Retrospective Timing of Tissue Storage by Kinetics of Proteom Alterations – The „Proteomic Clock” Concept Reduced isolated red signal pattern of ALK FISH in lung cancer patients AG01 Gastroenteropathologie - on demand .......................................................................................... 71 Significance of tumor regression in lymph node metastases of gastroesophageal adenocarcinomas after neoadjuvant treatment Y chromosome loss is a frequent event in Barrett´s adenocarcinoma and associated with poor outcome Loss of SMAD4 in gastric cancer is associated with poor patient outcome Combined Analysis of Computed Tomography and Histology Leads to an Evolutionary Concept of Echinococcus multilocularis Infections in Humans Establishing and Evaluation of a Polymerase Chain Reaction for the Detection of Echinococcus multilocularis in Human Tissue κB-Ras/Ral GTPase signalling regulates acinar-to-ductal metaplasia during oncogenic KRas-driven pancreatic adenocarcinoma development and pancreatitis Synergy between urokinase plasminogen activator receptor (uPAR) and mutated KRAS in the progression of pancreatic cancer: implications for chemotherapy Functional role of the extracellular matrix molecule Tenascin C during pancreatic regeneration Molecular markers in pancreatic neuroendocrine tumors (PanNET): Correlation with histopathological data and prognosis. Lactate transporter (MCT4) expression in Pancreatic Microadenomas and Pancreatic
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