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Curriculum Vitae P. 1

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Curriculum Vitae P. 1 Curriculum Vitae p. 1 Name: Jakob Balslev Sørensen Title/degrees Privatdozent, Ph.D., M.Sc. Citizenship: Danish. Born: Hørsholm, Denmark on September 24th 1969. Marital status: Married to Christiane E. Sørensen, two children (4 and 8 years). Private address: Augustinerstrasse 30, 37077 Göttingen, Germany. Work address: Max-Planck-Institut für biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen, Germany. Office phone: +49 (0) 551 201 1297 Private phone: +49 (0) 551 205 2704 Fax: +49 (0) 551 201 1688 E-mail: [email protected] Education 2006 Privatdozent (December 12th 2006). Venia Legendi (“permission to teach”) in pre-clinical physiology at the Georg-August University of Göttingen. Habilitation supervisor: Prof. Dr. Diethelm Richter, Human Medicin, Göttingen University. (This is the German ‘Habilitation’). 1999 Ph.D. (September 23rd 1999). August Krogh Institute, Copenhagen University. Supervisor: Prof. Dr. Erik H. Larsen. Thesis title: Biophysical studies of ion channels. 1996 M.Sc./cand. scient. (February 14th 1996) in Biology (final and thesis note: 13, i.e. Highest Distinction), and Minor Degree in Mathematics from Copenhagen University, Denmark. 1988 Generel Certificate of Education (A-level): Marie Kruses Skole, Farum, Denmark. Work experience etc. 2009- Professor of Molecular and Cellular Neurobiology, Institute for Neuroscience and Pharmacology, Faculty of Health, Copenhagen University. 2009- Lektor (associate professor), Institute for Neuroscience and Pharmacology, Faculty of Health, Copenhagen University (from January 1st 2009). 2005-2008 Research Group Leader (current position), Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany. 2000-2005 Post-doctoral fellow, Prof. Dr. Erwin Neher, Membranbiophysik, Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany. 1999 Post-doctoral fellow, Prof. Dr. Erik H. Larsen, August Krogh Institute, Copenhagen University. 1998 Visiting scientist (for 6 months) as part of the Ph.D. thesis work with Prof. Dr. Francisco Bezanilla, Department for Anaesthesiology and Physiology, University of California Los Angeles, USA. 1996-1999 Ph.D. student at the August Krogh Institute, Copenhagen University. 1988-1996 Study of Biology (main subject) and Mathematics (minor subject) at Copenhagen University. Memberships of Ph.D. schools etc. since 2008 Faculty member of ‘Faculty of 1000’, Neuronal Signaling Mechanisms Section. since 2007 Faculty member and member of the study committee for the Ph.D. program ‘Molecular Physiology of the Brain’, Göttingen Graduate School for Neurosciences and Molecular Biosciences. since 2006 Faculty member of the International Max-Planck-Research School in the Neurosciences. since 2006 Faculty member of Georg August School of Science (GAUSS) with the right to act as Ph.D. supervisor and evaluator in the Natural Sciences Faculty, Georg August University Göttingen. since 2005 Faculty member of the NEUREST (neuroscience early stage research training) program, Göttingen. 1991-1993 Student member of the study committee (“Studienævnet”) for Biology, Copenhagen University. Research grants, stipends, awards Running research grants: 2009-2011 The Danish Medical research council, grant of € 270,000. 2009-2013 The Lundbeck foundation: Junior group leader Scholarship 2008, total of € 1.34 mio. Curriculum Vitae p. 2 (2008 Novo Nordisk Seniorforskerstipendiet 2008, total of € 765,100 over five years. The stipend has been returned to the foundation due to the overlapping grant from Lundbeckfonden). 2008-2011 “Scientist in charge” for a Marie Curie IEF FP7 stipend and an EMBO long-term fellowship, both given to Keimpe Wierda, Post.-doc. in my group since Oktober 2007. 2006-2008 Deutsche Forschungsgemeinschaft: ‘Special Research Area 523’ (SFB523), project B16: one Ph.D. student and €8000/year for three years. Total amount: approx. € 108,800. 2006-2008 Deutsche Forschungsgemeinschaft: ‘Graduate College 521’ (GRK521): one Ph.D. student and €8000/year for three years. Total amount: approx. € 64,000. Previous research grants, prices: 2005-2007 Deutsche Forschungsgemeinscaft: „The own position” SO 708/1-1&2 and €3500/year. Total amount: Approx. € 170,000. 2004-2005 ‘Scientist in charge’ for an EMBO long-term fellowship given to Jean-Sebastien Schonn. 2000 Danisch Research council for the Natural Sciences: relocation stipend. 1996 Gold medal, Copenhagen University 1994-1996 Novo Nordic Student Scholarship. Reviewer for Nature Cell Biology, PLOS Biology, EMBO Journal, Journal of Cell Biology, Journal of Neuroscience, Journal of General Physiology, Journal of Physiology, Biophysical Journal, Brain Research, American Journal of Physiology, Journal of Neurochemistry, Chemical Reviews, Proceedings of the National Academy of Sciences (USA), Homburger Forschungsförderungsprogramm (HOMFOR), Deutsche Forschungsgemeinschaft, INTAS u.a. Collaborations Prof. Thomas C. Südhof, Department of Neurosciences, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Themes: Synaptotagmin isoforms, knock-out mice. Prof. Nils Brose, Max-Planck-Institute for experimental medicine, Hermann-Rein-Str. 3, 37075 Göttingen, Germany. Themes: knock-out mice, biochemistry. Prof. Matthijs Verhage, Department of Functional Genomics, Vrije Universiteit Amsterdam, Amsterdam, Holland. Themes: Munc18-1, knock-out mice, electron microscopy. Prof. Manfred Lindau, School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA. Themes: fusion pore measurements, synaptobrevin mutations. Prof. Graham Ellis-Davies, Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, USA. Themes: calcium cages. Dr. Dirk Fasshauer, Forschungsgruppenleiter, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen. Themes: biochemical measurements of SNAREs. Prof. Reinhard Jahn, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen. Themes: biochemical measurements of SNAREs. Prof. Erwin Neher, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen. Themes: fluctuation analysis, deconvolution analysis, etc. Memberships American Physiological Society (Member since 2000). Society for Neuroscience (Member since 2002). Biophysical Society (Member since 2003). Society for General Physiologists (Member since 2004). Neurowissenschaftliche Gesellschaft (Member since 2005). Curriculum Vitae p. 3 Publications 1. Research papers 28. Cai H., Reim K., Varoqueaux F., Tapechum S., Hill K., Sørensen J.B., Brose N., and Chow R.H. (2008 – in press). Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming. Proc. Natl. Acad. Sci. (USA) 27. Fang Q., Berberian K., Gong L.W., Hafez I., Sørensen J.B., and Lindau M. (2008). The role of the C terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics. Proc. Natl. Acad. Sci. (USA) 105(40), 15388-15392. 26. Nagy G., Milosevic I., Mohrman, R., Wiederhold K., Walter A.M., and Sørensen J.B. (2008). The SNAP-25 linker as an adaptation towards fast exocytosis. Mol. Biol. Cell 19, 3769-3781. 25. Schonn J.S., Maximov A., Lao Y., Südhof T.C., and Sørensen J.B. (2008). Synaptotagmin-7 and -1 are functionally overlapping calcium sensors for exocytosis in adrenal chromaffin cells. Proc. Natl. Acad. Sci. (USA) 105, 3998-4003. 24. Maximov A., Lao Y., Li H., Chen X., Rizo J., Sørensen J.B., and Südhof T.C. (2008). Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis. Proc. Natl. Acad. Sci. (USA) 105, 3986-3991. 23. Jockusch W.J., Speidel D., Sigler A., Sørensen J.B., Varoqueaux F., Rhee J.-S, and Brose N. (2007). CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell 131, 796-808. 22. Delgado-Martinez I., Nehring R., and Sørensen J.B. (2007). Differential abilities of SNAP-25 homologues to support neuronal function. J. Neurosci. 27, 9380-9391. 21. Gulyás-Kovács A., de Wit H., Kochubey O., Milosevic I., Toonen R., Klingauf J., Verhage M., and Sørensen J.B. (2007). Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming. J. Neurosci. 27, 8676-8686. 20. Zilly F., Sørensen J.B., Jahn R., and Lang T. (2006). Munc-18-1 binding to syntaxin 1 allows for the initiation of the neuronal SNARE-zipper in native membranes. PLoS Biology Sep 26; 4(10):e330 doi:10.1371/journal.pbio.0040330. 19. Nili U., de Wit H., Gulyás-Kovács A., Toonen R.F., Sørensen J.B., Verhage M., and Ashery U. (2006). Munc18-1 phosphorylation by PKC potentiates vesicle pool replenishment in bovine chromaffin cells. Neuroscience 143, 487-500. 18. Toonen R.F., Kochubey O., de Wit H., Gulyas-Kovacs A., Konijnenburg B., Sørensen J.B., Klingauf J., and Verhage M. (2006). Dissecting docking and tethering of secretory vesicles at the target membrane. EMBO J. 25, 3725-3737. 17. Sørensen J.B., Wiederhold K., Müller E.M., Milosevic I., Nagy G., de Groot B.L., Grubmüller H., and Fasshauer D. (2006). Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles. EMBO J. 25, 955-966. 16. Nagy G., Kim J.H., Pang Z.P., Matti U., Rettig J., Sudhof T.C., Sørensen J.B. (2006). Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation. J Neurosci. 26, 632-643. Curriculum Vitae p. 4 15. Nagy G., Milosevic I., Fasshauer D., Muller E.M., de Groot B.L., Lang T., Wilson M.C., and Sørensen J.B. (2005). Alternative Splicing
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