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Table of Contents

Words of Welcome 3 Contact Information 8 Committees 9 About EFIS 11 Awards 12 EFIS Awards 13 Waived Registration Fee Grants 15 Congress Information 16 Information for Speakers and Poster Presenters 18 Program at a Glance 19 Scientific Program 24 Keynote and Plenary Lectures 28 Scientific Program by Day 31 Industry Sponsored Symposia, Sponsoring and Exhibition 82 Acknowledgements 84 Company Descriptions 86 Industry Sponsored Sessions 89 Exhibition Information 92 Virtual Social Program 93 Science Communication Workshops & Performance 93

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Words of Welcome

Welcome by the Congress President

Dear Fellow Immunologists and Colleagues, On behalf of the Turkish Society of Immunology (TSI), the Immunological Society of Serbia (ISoS) and the European Federation of Immunological Societies (EFIS) we sincerely welcome you to the th6 European Congress of Immunology (ECI 2021) which will be held virtually from Istanbul between September 1-4, 2021. We hope that all of you and your loved ones are in good health and keeping yourselves safe and sound from the devastation of the COVID-19 pandemic. Sadly, we were obliged to transform this triennial world-renowned immunology congress from a face-to- face meeting to a fully virtual format. The motto of the 6th ECI is “Opening Doors to the World of Immunology”. Anatolia has been the grassroots of many civilizations and Istanbul has stood for centuries as the main door connecting the Asian continent to Europe. We have been the proud gatekeepers of these major civilizations over centuries and are honored to nurture and preserve these World heritage sites. The 6th ECI covers all fields of modern immunology and the program outline of ECI 2021 has been specifically designed with the ‘Opening Doors to the World of Immunology” concept in mind. Throughout establishing the scientific and social program, people from immunological societies all over Europe and the rest of the world have passionately collaborated and we are appreciative of all parties’ efforts. We have much enjoyed the truly international contributions while constructing an attractive program for ECI 2021. In the wake of the COVID-19 pandemic, our Organizing Committee had to adapt the program to a fully virtual format that guarantees an event covering full spectrum of immunology-related basic and applied research with exceptional keynote and plenary sessions that feature two Nobel Laureates and a panel of internationally renowned top-notched scientists. The ECI 2021 scientific program stages more than 550 speakers from 60 countries in 106 sessions over the course of 3.5 busy days. In the opening day, two Nobel Laurates will share their lifelong scientific experiences in their opening keynote lectures. The program also offers 2 more keynote and 4 stellar plenary lectures. Sixty top-notch scientists will get the chance to share their groundbreaking research in the main scientific sessions. Fifteen immunological societies in 13 joint sessions will host 48 presentations. Several COVID-19 sessions will cover vaccine development and regulation as well as the clinical status of the pandemic. We have initiated for the first time a special session dedicated to young EFIS members. An exciting session not to be missed that was completely organized by our young immunologist fellows. Among 1535 abstracts submitted to the congress, a total of 1416 were selected by the Scientific Program Committee to be presented. This includes 339 oral presentations distributed to49 workshop sessions and highest rated 24 abstracts that were nominated for four Bright Sparks sessions.

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The poster sessions will be on show throughout the entire congress period and best poster candidates will be shortlisted and awarded as the best poster winners during the closing ceremony. The four-track scientific program aims to connect basic immunological research to clinical applications and highlight emerging fields in immunology and related medical fields. In industry sponsored sessions, companies will showcase technology platforms that “open doors” for cutting edge immunology research. Among several activities, one of the unique entertainments we have selected to offer to you is the live performance on science communication. We are certain that this unique social activity will be one of the highlights of the conference. While there were several challenges due to COVID-19 and besides much unanticipated hurdles, we sincerely enjoyed the making of the ECI 2021. We appreciate all your efforts to join our meeting and to take part in the international exchange of scientific discussions and ideas. We hope that you will enjoy ECI 2021! With best wishes, Gunnur Deniz ECI 2021 Congress President

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Welcome by the TSI President

Dear Friends and Dear Colleagues, The Turkish Society of Immunology (TSI) welcomes you to the 6th European Congress of Immunology, ECI 2021. We are honored to organize ECI 2021 together with Immunological Society of Serbia (ISoS) on behalf of the European Federation of Immunological Societies (EFIS). The TSI aims to develop and maintain the highest standards in the practice and teaching of basic and clinical immunology in Turkey, and to promote collaboration between clinical immunologists and basic scientists’ nation and worldwide. Also, the TSI shares the values of EFIS and IUIS, and participates in their activities to be a global player in immunology. In line with our aims, we consider it a privilege to organize the 6th European Congress of Immunology. In these unprecedented times, as our globalized world was turned upside down by the COVID-19 pandemic, TSI has remained strong during this period, and its members and officers have kept working hard to prepare for the upcoming ECI 2021 undaunted by the difficulties created by the pandemic. Now, TSI is looking forward to the time when the European Immunology network can again be together to listen, discuss and exchange ideas during ECI 2021. We thank you for joining us at the 6th European Congress of Immunology to enjoy and share science together! Yours faithfully, H. Barbaros Oral President TSI

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Welcome by the ISoS President Dear Colleagues and Friends, On behalf of the Immunological Society of Serbia, it is our great pleasure to welcome you to the 6th European Congress of Immunology (ECI) which is held from September 1-4, 2021. ECI 2021 is hosted by the Turkish Society of Immunology (TSI) and the Immunological Society of Serbia (ISoS), and it is a virtual meeting to ensure safety and health of the participants in the ongoing pandemic. We would like to express our gratitude and pleasure that we had the opportunity to co-organize ECI 2021 with TSI with the focus on “opening doors to the world of immunology”. The 6th ECI will cover all fields of immunology, basic and applied, and related interdisciplinary fields, and also present new discoveries in the fundamental immunology through the four-track program dedicated to ‘Cellular Immunology’, ‘Molecular Immunology’, ‘Diseases and Immune Response’ and ‘Innovative Technologies and Immunotherapies’. The scientific program includes interesting plenary sessions staged by established world-leading scientists in basic and translational immunology, symposia, oral short presentations sessions and e-poster sections in addition to joint symposia with guest societies. The state-of-the-art virtual platform will enable networking within participants and provide exposure to exciting new data from the whole immunological community. The Immunological Society of Serbia (ISoS) originates from the Yugoslav Immunological Society (YIS) founded in 1968 in Belgrade and registered in 1974. As part of YIS, ISoS carried out all the important tasks including dissemination of the scientific findings and improvement inthe teaching of immunology at several universities in Serbia. In 1969, YIS was one of the ten founding members of the International Union of Immunological Societies (IUIS) and also contributed to the establishment of the European Federation of Immunological Societies (EFIS) in 1975. After the breakup of the country (1991), YIS was located in the Federal Republic of Yugoslavia (Serbia and Montenegro) and its work was maintained through ISoS activities. In spite of the economic and political upheavals a great achievement at that time was founding the Balkan Association of Immunological Societies, which took place at the1st Balkan Congress of Immunology BAIS in Belgrade 1995. Since 2006, the name of the Society was returned to ISoS. Members of ISoS maintain scientific excellence and organize regular scientific meetings and national symposia. Appreciating this, EFIS entrusted the organization of two EFIS/EJI meetings in Belgrade toDr. Miodrag L. Lukic and ISoS (2004, 2008) and supported the organization of Belgrade conference Immunology at the Confluence of Multidisciplinary Research in 2019. The current number of ISoS members is 130 and it is continually expanding with the accession of young scientists. We will do our best to make the 6th ECI a most memorable scientific event. We look forward to meeting you virtually in September 2021! Sincerely, Nada Pejnovic President ISoS

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Welcome by the EFIS President Dear friends and colleagues, As President of the European Federation of Immunological Societies (EFIS), I am delighted to welcome you to the European Congress of Immunology 2021 (ECI 2021). The triennial European Congress of Immunology has been a pinnacle event in the calendar of European immunologists since the first congress was held in Paris back in 2006. The following congresses in Berlin, Glasgow, Vienna and Amsterdam then established it as the preeminent congress for European immunologists. The ECI 2021 was originally planned to take place in Belgrade, Serbia, jointly organized by the Turkish and Serbian Societies for Immunology. Preparations were well underway when the COVID-19 pandemic struck and it was only a few months ago that the ECI 2021 Steering Committee, in unison with the EFIS Board, grudgingly had to decide to hold the ECI 2021 as a fully virtual meeting, in view of the still ongoing pandemic and the many travel restrictions in place. It is fair to say that the run-up to the ECI 2021 has been anything but easy for the organizing teams. They did a splendid job in managing all these challenges, congratulations! On behalf of EFIS, I would like to thank those involved in the organization of the congress, in particular the Congress President, Gunnur Deniz and her team for their incredible hard work and determination for bringing together the wonderful program that we are about to enjoy. While we are sad not to be enjoying the in-person hospitality of our Serbian hosts and Turkish organizers, in terms of scientific content, the virtual program in no way disappoints! As this is the first ECI incorporating EFIS Study Groups, EFIS Task Forces, and young EFIS into the scientific program, I also encourage you to join these dedicated symposia for what are sure to be stimulating sessions. Furthermore, let’s not forget that one major positive facet of the last 1.5 years has been that immunological research has emerged from this pandemic triumphant. We can be proud of our community for those many essential contributions to SARS-CoV-2 research, treatment, testing, and vaccine development. Indeed, much of this fantastic work will be presented here at the ECI 2021. An advantage of the virtual format of the ECI 2021 is that it affords us to reach out globally, sharing our science with colleagues worldwide, a theme perfectly encapsulated by the congress slogan “opening doors to the world of immunology”. Therefore, welcome to all our first time ECI delegates! The ECI 2021 will implement a state-of-the-art virtual platform to provide participants, speakers, and industrial partners access to the scientifically stimulating program. Please take advantage of the valuable discussion and networking opportunities through various chat functions and be sure to check out the immunology village to get a full experience of the congress. EFIS is proud to concentrate on supporting the integration of early career scientists; we hope that through the provision of an unprecedented number of waived registration grants for this congress, many such researchers will benefit from presenting their research over the next few days. Finally, don’t forget to join us for the ACTERIA AND EFIS awards session to support your colleagues and friends in their great achievements! Enjoy the congress! Best wishes, Andreas Radbruch

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Contact Information Organized under the auspices of EFIS - European Federaion of Immunological Socieies www.efis.org Co-organized by TSI – Turkish Society of Immunology www.turkimmunoloji.org ISoS – Immunological Society of Serbia https://www.isos.rs

1974 Congress President TURKISH SOCIETY OF IMMUNOLOGY Prof. Dr. Gunnur Deniz Istanbul University Director of Aziz Sancar Institute of Experimental Medicine Head of Department of Immunology Past President of Turkish Society of Immunology E-mail: [email protected] Scientific Program Co-Presidents Prof. Dr. Ihsan Gursel Bilkent University, Department of Molecular Biology and Genetics, Ankara, Turkey E-mail: [email protected] Prof. Dr. Miodrag Lukic University of Kragujevac Department of Molecular Medicine Kragujevac, Serbia E-mail: [email protected]

Conference Organizer Exhibition Management & Sponsoring: Serenas International Tourism Congress Organization C.O. Başöğretmen Cad. Mor Orkide Sok. No:3 Küçükbakkalköy, Ataşehir, İstanbul, Turkey Phone: +90 216 594 58 26 E-mail: [email protected] | [email protected] ECI 2021 Congress President’s Office Ayse Askin Erten (Ms.) Phone: +90 532 2142513 E-mail: [email protected] EFIS Offices Mairi.McGrath – EFIS President’s Office E-mail: [email protected] Thomas Wiley – Coordinator E-mail: [email protected] 6th European Congress of Immunology, September 1-4, 2021 9

Committees

ECI 2021 Steering Committee Gunnur DENIZ, Congress President, TSI Marcos LOPEZ HOYOS, SEI Andreas RADBRUCH, EFIS President, Renato MONTERIO, SFI Ihsan GURSEL, ECI 2021 SPC Co-President, TSI Barbaros ORAL, TSI Djordje MILJKOVIC, LOC Co-President, ISoS Trevor OWENS, SSI Arne AKBAR, BSI Alexander ROSENKRANZ, OGAI Cezmi AKDIS, TSI Tamara SAKSIDA, ISoS Amiram ARIEL, IIS Marta SZELL, MIT Marco A. CASSATELLA, SIICA Alexandra TSIROGIANNI, HSI Thomas KAMRADT, DGFI Marieke VAN HAM, NVVI Antonio LANZAVECCHIA, SSAI Luca VANNUCCI, CIS Ed LAVELLE, ISI

Fiona CULLEY, BSI Substitute Winfried PICKL, ÖGAI Substitute Nikolaou CHRYSOULA, HSI Substitute PeterBALOGH, MIT Substitute Marie CERNA, CIS Substitute Eva Martinez CACERES , SEI Substitute

ECI 2021 Finance Committee

Winfred PICKL, EFIS Hanna JARVA, SSI Francesco ANNUNZIATO, SIICA Sylvia KNAPP, OGAI Arzu ARAL, TSI Aude MAGERUS, SFI Jordi CANO ORCHANDO, SEI Carsten WATZL, DGFI Fiona CULLEY, BSI Paul Guglielmi, SFI Substitute Mirjam HEEMSKERK, NVVI Manel Juan, SEI Substitute

ECI 2021 Scientific Program Committee

Ihsan GURSEL, ECI 2021 Co-President, TSI Wilfried ELLMEIER, TCC EUROPE Miodrag LUKIC, ECI 2021 Co-President, ISoS Dominik FILIPP & Anna SEDIVA, CIS Gunnur DENIZ, Congress President, TSI Asimina FYLAKTOU, HSI Francesco ANNUNZIATO, SIICA Luis GRAÇA, SPI Silke APPEL, SSI Ahmet GUL, TSI Mira BARDA-SAAD, IIS Peter HEERINGA, NVVI Edit BUZÁS, MIT Michael LOHOFF, DGFI Mark COLES, BSI Eva MARTINEZ CACERES, SEI

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Kingston MILLS, ISI Tolga SUTLU, TSI Nada PEJNOVIC, ISoS Andrey TCHORBANOV, BUSI Guher SARUHAN DIRESKENELI, TSI Jacek WITKOWSKI-PSI Delphine SAUCE, SFI Jürgen WITTMANN, NC RNA IMMUNE Idit SHACHAR, EUROPEAN B CELL NETWORK REGULATION Barbara SELIGER, TIMER Hannes STOCKINGER, ÖGAI Amiram ARIEL, IIS Substitute

ECI 2021 Local Organizing Committee

Gunnur DENIZ, Congress President, TSI Aleksandra POPOV ALEKSANDROV, ISoS Yildiz CAMCIOGLU, LOC Co-President, TSI Alisa GRUDEN-MOVSESIJAN, ISoS Djordje MILJKOVIC, LOC Co-President, ISoS Goran MARJANOVIĆ, ISoS Miodrag LUKIC, ECI 2021 SPC Co-President, ISoS Ivan PILIPOVIĆ, ISoS Ihsan GURSEL, ECI 2021 SPC Co-President, TSI Lazar POPOVIĆ, ISoS Cem AR, TSI Milos MARKOVIĆ, ISoS Ceren CIRACI, TSI Suzana STANISAVLJEVIC, ISoS Ayca SAYI YAZGAN, TSI Mirjana NACKA ALEKSIĆ, ISoS Dicle GUC, TSI Natasa ILIĆ, ISoS Mayda GURSEL, TSI Nemanja JOVIČIĆ, ISoS Gunes ESENDAGLI, TSI Sergej TOMIĆ, ISoS Asli GELINCIK, TSI Slavko MOJSILOVIĆ, ISoS Haner DIRESKENELI, TSI Biljana LJUJIĆ, ISoS Elif KARAKOC AYDINER, TSI Srda JANKOVIĆ, ISoS Duygu SAG, TSI Tanja DŽOPALIĆ, ISoS

EFIS BOARD 2019-2021

Andreas RADBRUCH, President Federica SALLUSTO, President-elect René A.W. VAN LIER, Past President Pablo ENGEL, Secretary General Winfried PICKL, Treasurer

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About EFIS

The European Federation of Immunological Societies (EFIS) is a non-profit umbrella organization that represents35 European immunology societies, including, as well, associations from Eurasia and the Middle-East. Every active member of any of EFIS-affiliated society is automatically considered a “member” of EFIS and can as such benefit from EFIS programs. EFIS thus acts as organization uniting nearly 14,000 individual researchers and clinicians working in the fields of immunology and allergology. The main goals of EFIS are the support of immunological research and education as well as strengthening scientific interaction amongst the members with: Supporting young scientists, e.g. through fellowships or travel grants. Supporting congresses and conferences in Europe Promoting Immunology to the general public through the Day of Immunology, and other activities: check out the interactive exhibition www.inside-immunity.org or the interactive book www. interactive-immunity.org For more information about EFIS please visit www.efis.org

EFIS on social media @efis_immunology

htps://www.facebook.com/European-Federaion-of-Immunological-Socieies- EFIS-620599097957021/

htps://www.linkedin.com/company/europeanfederaionoimmunologicalsocieies/

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Awards

ACTERIA Prizes awarded by EFIS On the recommendations of the ACTERIA Prizes selection Jury and the Fondation ACTERIA, EFIS is delighted to announce the laureates of the 2021 ACTERIA Prizes awarded by EFIS: 2021 ACTERIA Early Career Research Prize Laureate in Immunology Charlotte Scott, VIB-UGent, Center for Inflammation Research, Belgium 2021 ACTERIA Early Career Research Prize Laureate in Allergology Nicolas Guadenzio, Toulouse Institute for Infectious and Inflammatory Diseases, France The ACTERIA Prizes will be formally conferred at a specially organized session on Thursday, September 2nd, 17:15 – 18:45 CET (Hall 5) during which each of the two laureates will present her/his work. The ACTERIA Early Career Research Prizes carry a cash award of EUR 15,000. In addition, awardees automaically qualify for 3-year research grants of up to EUR 50,000 annually. EFIS/EJI Ita Askonas Award The Ita Askonas Award was established by EFIS and the European Journal of Immunology (EJI) in recognition of outstanding female group leaders in immunology who have run an independent laboratory for a minimum of four and no more than eight years. This year, the award will be conferred, Thursday, September 2nd, 17:15 – 18:45 CET (Hall 5) to Christiane Opitz, Neurology Clinic and National Center for Tumor Diseases, University Hospital of Heidelberg. 2021 marks the fifth time that the Award will be conferred.

EFIS Eastern Star Award EFIS is pleased to announce the winners of the 2021 Eastern Star Awards • Đorđe Miljković, Department of Immunology, Institute for Biological Research “Siniša Stanković”, University of Belgrade for his proposed research on the role of gut microbiota and gut immune cells in the CNS-directed autoimmunity induced in rats without the use of the complete Freund’s adjuvant • Ondřej Štěpánek, Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, for his project on the molecular basis of T-cell memory. Awards will be presented during the ACTERIA-EFIS Awards Ceremony on Thursday, September 2nd, 17:15 – 18:45 CET (Hall 5)

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EFIS Awards

EFIS-BioLegend Bright Sparks Awards With the generous support of BioLegend, EFIS is able to sponsor 24 Bright Sparks Awards during the ECI 2021. The Scientific Program Commitee selected the 24 best abstracts submitted by early career scientists. Those abstracts are presented in the „Bright Sparks“ workshops. In addition to recognition as an ECI 2021 „Bright Spark“, they will also receive a EUR 500.- cash prize. Prizes will be awarded during the Virtual Closing and Award Ceremony, Saturday, September 4th at 15:00 CET (Hall 1).

EFIS Best Poster Awards EFIS will award 24 Best Poster Presentations chosen from the posters presented during the virtual ECI 2021. The winners will receive a EUR 300.- cash prize. New for the virtual format, the Scientific Program Committee shortlisted most notable poster abstracts. The Best Poster Jury evaluated these shortlisted poster presentations, and selected poster award candidates who will be invited for BEST POSTER SESSIONS within the main program of the congress. Best Poster session chairs will then evaluate and make the final decision on winners in each session. Prizes will be awarded during the Virtual Closing and Award Ceremony, Saturday, September 4th at 15:00 CET (Hall 1).

ECI 2021 Organization Committee would like to extend their special thanks to Best Poster Jury for their contribution and time:

Akif Turna, Turkey Jacques Neefjes, The Netherlands Alessio Mazzoni, Italy Janneke Samsom, The Netherlands Ali Önder Yıldırım, Germany Marieke van Ham, The Netherlands Alisa Gruden-Movsesijan, Serbia Megan Macleod, United Kingdom Barbara Cassani, Italy Mila Kverka, Czech Republic Blanka Rihova, Czech Republic Mirjam Heemskerk, The Netherlands Ed Lavelle, Ireland Mirjana Nacka Aleksić, Serbia Esther de Jong, The Netherlands Peter Heeringa, The Netherlands Giuseppe Sciume, Italy Silva Piconese, Italy Gunnur Deniz, Turkey Suhendan Ekmekçioğlu, USA Helen McGettrick,United Kingdom Tamara Saksida, Serbia

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Isil Berat Barlan Awards The Turkish Society of Immunology (TSI), together with Professor Talal Chatila from Harvard Medical School, presents the following three awards in honor of colleague, the late Prof. Isil Berat Barlan, a distinguished physician-scientist and an educator that made invaluable contributions to the fields of Allergy and Immunology in Turkey and internationally, every year since 2016. TSI is delighted to announce the laureates of these awards for 2021:

Isil Berat Barlan Award for Women Scholars in Immunology Carolin Daniel Helmholtz Zentrum München, Germany Isil Berat Barlan Award in Primary Immunodeficiency Diseases Kaan Boztug St. Anna Children’s Cancer Research Institute, Vienna, Austria Medical University of Vienna, Austria Isil Berat Barlan Award for Young Scientists in Immunology Ioannis Kourtzelis York Biomedical Research Institute, University of York,United Kingdom Charlotte Scott VIB-UGent, Center for Inflammation Research, Belgium Isil Berat Barlan Awards will be presented virtually by Prof. Talal Chatila at the end of the Women and Men in Immunology Session on Friday, September 3rd at 18:30 CET (Hall 5)

EFIS Diversity Task Force Publication Award The award was established by EFIS Task Diversity Task Force to acknowledge a scientist from a minority group or a developing country who has been the main author of at least two SCI-indexed publications in immunology within the last five years. This prize consists of a €1000 cash award and researchers from EFIS member societies are encouraged to apply for this prestigous award. It will be presented for the first time at the 6th Congress of Immunology. EFIS Task Diversity Task Force is happy to present this year’s award to Ahmet Oguzhan Ozen from Marmara University Medical Faculty, Division of Pediatric Allergy - Immunology, during the Virtual Closing and Award Ceremony Saturday, September 4th at 15:00 CET (Hall 1)

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Waived Registration Fee Grants

ECI 2021 Organization Committee would like to extend their special thanks to the following organizations who have supported young scientists with waived registration fee grants. The European Federaion of Immunological Socieies (EFIS) has awarded 379 waived registration fee grants for young post-docs and PhD-students under 40 years of age requesting financial support to attend the virtual ECI 2021. International Union of Immunological Societies (IUIS) has awarded 11 waived registration fee grants for young post-docs and PhD-students under 40 years of age requesting financial support to attend the virtual ECI 2021. American Associaion of Immunology (AAI) has awarded 21 waived registration fee grants for their members requesting financial support to attend the virtual ECI 2021. Turkish Society of Immunology (TSI) has awarded 27 waived registration fee grants for their members requesting financial support to attend the virtual ECI 2021. The 6th European Congress of Immunology was also able to support total of 61 participants with waived registration fee grants by the educational grants provided by BD and 10x Genomics.

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Congress Information

6th European Congress of Immunology takes place virtually on virtualeci2021.com

Certificate of Attendance and Continuing Medical Education (CME) Credits Certificates of Attendance will be available to download on the platform from the kiosk named “CERTIFICATE”. This kiosk will become active on Wednesday, September 1st. The Sixth European Congress of Immunology, Online, Turkey, 01/09/2021-04/09/2021 has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with 19 European CME credits (ECMEC®s). Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 CreditsTM. Information on the process to convert EACCME® credit to AMA credit can be found at www.ama-assn.org/education/earn-credit-participation-international- activities. Live educational activities, occurring outside of Canada, recognised by the UEMS-EACCME® for ECMEC®s are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada. CME certificates can be claimed after the congress. More information on CME is available also on the platform on the “CME” kiosk. Participants, who are willing to claim CME credits, must fill out the survey on the virtual platform. After the congress, ECI Organization team will calculate the hours of credit that she/he spent in the educational activity and will issue the certificate to the participant.

Conference Language The official meeting language is English. All submitted abstracts, full papers, general correspondence and meeting sessions will also be in English. Time Zone of Scientific Program All session times mentioned in the program are CET (Central European Time). Please note you must select time zone while viewing the scientific program on the program. Information Desk You may contact our staff via chat feature on the platform. You may also click on “Info Desk” icon to reach the correct department for your questions. Online Program Planner Once you login in the virtual congress platform, you will be able to view the full scientific program and full information on all sessions, speakers and chairs. The online program enables you to view the program in your own time zone. You can also select presentations to add to your calendar in various systems (such as MS Outlook and Google calendar).

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Recording and on Demand Taking screen shots or making any other form of electronic recording during the sessions is forbidden. Recordings of the sessions (of whom gave consent) will be available on demand for all registered participants after the congress until December 31, 2021. Social Media #ECI2021 @2021ECI

@eci_2021

www.facebook.com/ECI2021

Society Village Virtual Immunological village is located in the virtual exhibition hall. National EFIS affiliated societies as well as international associations will provide a plaform for international exchange. You may visit their booth and communicate via chat or messaging features.

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Information for Speakers and Poster Presenters

Due to EACCME regulations, authors are requested to disclose possible conlicts of interest on the first slide or on the poster. Detailed information and instructions for all speakers, workshop and poster presenters are available on the www.eci2021.org and under on virtualeci2021.com

E-Poster Hall Poster sessions have always been the major scientific presentations of the meeting since the majority of congress attendees present a poster showing data and progress with their research.On the virtual congress platform, there will be an E-Poster Hall where researchers can present their posters. Interactive e-poster platform will enable poster authors to connect with the audience via messaging, comment box or chat functions.

6th European Congress of Immunology, September 1-4, 2021 19 HALL 3 Therapeutic Approaches in Rheumatology Approaches Therapeutic An Update in Immune Mechanisms and Novel in Immune Mechanisms and Novel Update An 15:00 - 20:00 HALL 2 of Clinical Phenotypesof Clinical PRE-CONGRESS EDUCATIONAL MEETINGS PRE-CONGRESS EDUCATIONAL Inborn Errors Immunity: Expanding Spectrum An Inborn Errors Program at a Glance at Program 09:15 - 17:40 Note: All times mentioned are Central European Time European are Central All times mentioned Note: HALL 1 Cytometry: Flow Advanced Taking Cytometry to the Next Dimension to Cytometry Taking 10:00 - 15:30 AUGUST 31 AUGUST

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Track 3 Track Track 3 Track Track 3 Track HALL 10 WS.T3.03 WS.T3.05 WS.T3.06 Molecular Triggers of Triggers Genetic and Inflammation Autoimmunity Environmental Environmental Mechanisms of Immune deficiencies

Track 3 Track Track 3 Track Track 1 Track HALL 9 WS.T3.01 WS.T3.02 WS.T1.06 Mechanism Inflammation Immune Response Regulation: Cellular Cellular Regulation: Allergy and Asthma Allergy Cellular Mechanism of Mechanism of Cellular

Track 4 Track Track 1 Track Session HALL 8 JS. - RSI WS.T4.05 WS.T1.09 Vaccines in Vaccines Immunotherapy Myeloid Lineage Myeloid Russian Scientists Early Stage Career Career Stage Early

Track 2 Track Track 2 Track HALL 7 WS.T2.01 modulation WS.T2.02.02 Immunology and Signaling JS. - ASI / DGFI and Transcriptional and Transcriptional Immune Regulation Immune Regulation Immune Regulaltion Intercontinental T Cell Intercontinental

Nature Track 1 Track Track 1 Track HALL 6 BP.T1.01 WS.T1.03 JS. - ESID Experiments of Experiments in Immunology: in Immunology: Innate Immunity Innate of Major Pathways of Major Pathways Human Inborn Errors Human Inborn Errors Cellular Immunology Cellular BREAK BREAK BREAK LUNCH BREAK LUNCH

Track 4 Track Track 4 Track HALL 5 JS. - JSI BS.T4.01 WS.T4.01 Vaccines and Vaccines Immunology Immunotherapies Bioinformatics and Bioinformatics Antiviral Immunity Antiviral Immunosensing and

S4.1 MS4.1 Cancer Track 4 Track Track 4 Track HALL 4 JS. - EFI signaling Visualizing Visualizing lymphocytes Mechanisms in Immunological Immunotherapy Immunogenetics of Allergic Diseases and Allergic

S3.1 MS3.1 Track 3 Track Track 3 Track HALL 3 Response JS. - EAACI Challenge of Challenge The Immune The Mucosal Immune Mucosal COVID-19 Infection COVID-19 for Allergic Patients Allergic for Note: All times mentioned are Central European Time European are Central All times mentioned Note: Immunometabolism S2.1 MS2.1 Track 2 Track Track 2 Track HALL 2 JS. - IUIS Immunity and Aging Symposium Immune System Microbiota and the Microbiota COVID Vaccines and Vaccines COVID Industry Sponsored -Immunomodulation -Immunomodulation KL3 to It to S1.1 KL.1 KL.2 MS1.1 Track 1 Track Track 1 Track HALL 1 Opening Lounge* Depletion Ceremony Single Cell Single Cell JS. - EULAR Symposium Homeostasis Influences on Influences Epithelial Cell Cell Epithelial Environmental Environmental Rheumatology Responses and Regulation T Cell JULES HOFFMANN Latest insight on B insight Latest Intestinal Immune Intestinal PETER J. RATCLIFFE PETER J. Respond to Oxygen Respond to Industry Sponsored Industry Sponsored Story of How Innate Story Innate of How Immune Cells Sense Immune Cells How Cells Sense and Cells How Danger and Respond cell effector functionscell BRIGITTA STOCKINGER BRIGITTA 11:15 12:30 10:00 11:00 13:00 14:15 14:30 17:15 15:30 16:00 17:30 17:45 18:45 20:00 11:00 11:15 09:30 10:00 12:30 13:00 14:15 16:00 14:30 15:30 17:15 17:30 17:45 19:00 SEPTEMBER 1

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Track 3 Track Track 3 Track HALL 10 WS.T3.08 WS.T3.09 Specific Immunity Regulation Regulation of Tissue Parasitic Immunology Parasitic Microbial, Fungal, and Fungal, Microbial, Maintenance and Local and Local Maintenance

Track 4 Track Track 1 Track HALL 9 WS.T4.06 WS.T1.07 and Immunotherapies T Lymphocyte Function T Lymphocyte Innovative Technologies Technologies Innovative

BREAK Track 1 Track Track 3 Track HALL 8 WS.T1.01 WS.T3.13 B Lymhocyte B Lymhocyte Neuroinflammation & Function Regulation

Track 2 Track Track 4 Track HALL 7 Allergies WS.T2.03 WS.T4.04 Therapy in Therapy Immune Response Autoimmunity and Autoimmunity Regulation: Metabolism Regulation:

Track 1 Track Track 2 Track HALL 6 BP.T2.01 BS.T1.01 Cellular Immunology Cellular Molecular Immunology BREAK BREAK LUNCH BREAK LUNCH

Awards HALL 5 Publishing ACTERIA & EFIS ACTERIA Expert’s Guide to Guide to Expert’s

S4.2 MS4.2 Track 4 Track Track 4 Track Lounge HALL 4 Symposium Symposium BSI Interactive BSI Interactive Dendritic Cells in Dendritic Cells Immune Response Industry Sponsored Immunotherapy Cancer

S3.5 MS3.2 Track 3 Track Track 3 Track Session Lounge Lounge HALL 3 Response Development Innate Immune Innate Note: All times mentioned are Central European Time European are Central All times mentioned Note: COVID-19 Vaccine Vaccine COVID-19 EJI-yEFIS Interactive EJI-yEFIS Interactive Progress in Technoology Progress in Technoology

S2.2 MS2.2 Track 2 Track Track 2 Track Session Lounge HALL 2 Cell Death in Death Cell Immunology Adaptive to Innate Industry Sponsored Progress in Technoology Progress in Technoology

PL.1 PL.2 S1.3 MS1.2 BREAK BREAK Track 1 Track Track 1 Track HALL 1 as well? Therapy and disease Symposium Symposium MARK DAVIS MARK UĞUR ŞAHIN Vacccine Inequity Vacccine Discussion Lounge: JOACHIM SCHULTZE JOACHIM Immune Responses Industry Sponsored FEDERICA SALLUSTO us for other diseases us for NK Cell Biology from Biology from NK Cell ANDREA COSSARIZZA something that helps something that Regulation of Adaptive of Adaptive Regulation President’s Symposium Symposium President’s Human T cells in health T cells Human Basic Science to Clinical Clinical Basic Science to Single Cell Omics and a Single Cell pandemic: Did we learn pandemic: Did we 10:15 10:30 11:15 11:30 12:45 14:00 13:00 13:30 14:30 15:30 17:00 17:15 18:30 18:45 09:30 10:15 10:30 11:15 11:30 13:30 12:45 13:00 14:00 14:30 15:30 17:00 17:15 18:30 SEPTEMBER 2

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Tumor Tumor Track 3 Track Track 3 Track Track 3 Track HALL 10 WS.T3.17 WS.T3.18 WS.T3.14 COVID 19 - 1 COVID microenvironment Viral Immunology 2 Viral

Track 3 Track Track 3 Track Track 3 Track HALL 9 in Cancer WS.T3.07 WS.T3.16 WS.T3.12 Mucosal ImmunityMucosal Viral Immunology 1 Viral Immune Regulation Immune Regulation

BREAK Track 1 Track Track 1 Track Track 1 Track Disease HALL 8 Function WS.T1.08 WS.T1.04 WS.T1.10 T Lymphocyte T Lymphocyte Regulation and Regulation Immune Response in Cell Lymphoid Innate

Track 1 Track Track 4 Track HALL 7 WS.T1.02 WS.T4.02 Responses Development T Cell - Adaptive Immune - Adaptive Cancer Immunotherapy Immunotherapy Cancer

Track 3 Track Track 3 Track Track 4 Track HALL 6 BP.T3.01 BP.T4.01 BS.T3.01 Responses Responses Diseases and Immune Diseases and Immune and Immunotherapies Innovative Technologies Technologies Innovative BREAK BREAK BREAK LUNCH

Cancer Track 2 Track HALL 5 JS. - SEI BS.T2.01 Ceremony Force Panel Force Translational Translational Immunology Immunotherapy in Immunotherapy Women and Men in Women The EFIS Vaccine Task Task The EFIS Vaccine Molecular Immunology Işıl Berat Barlan Awards Barlan Awards Berat Işıl

S4.3 MS4.3 Track 4 Track Track 4 Track Session HALL 4 Crosstalk JS. - ESRI Emerging Tools in Tools Emerging Immune Response New technologies in technologies New immunology research Feto-Maternal Immune Feto-Maternal Progress in Technoology Progress in Technoology

S3.3 Track 3 Track MS3.3 Track 3 Track Session HALL 3 immunology Transplantation Note: All times mentioned are Central European Time European are Central All times mentioned Note: Pearls of Russian Pearls JS. - RSI and RAACI Immunotherapy in Immunotherapy Autoimmune Diseases Autoimmune Progress in Technology Progress in Technology

S2.3 S2.4 Track 2 Track Track 2 Track HALL 2 JS. - ISAC COVID-19 COVID-19 Symposium Vaccinology Challenges in Challenges Industry Sponsored What we have learnt learnt have we What from the pandemics? from Vaccine Development Development Vaccine and Regulatory issues: Cytometry for Fighting Fighting for Cytometry BREAK S1.4 S1.5 PL. 3 JANKO JANKO Track 1 Track Track 1 Track Choices HALL 1 JS. - AAI Lounge* Symposium and disease applications yEFIS Session interactions and interactions their therapeutic their therapeutic Microbiome-host NIKOLICH-ZUGICH Health and DiseaseHealth Industry Sponsored Industry Sponsored Regulatory T Cells in T Cells Regulatory B cell differentiation differentiation B cell I Go - Navigating the I Go - Navigating Rough Seas of Career Rough Seas of Career Ages Immune System Damage, Defense and Damage, and function in health Adaptation – How the – How Adaptation Should I Stay or Should Should I Stay 10:45 11:00 12:45 13:15 13:45 14:15 14:30 15:45 16:15 18:45 17:00 19:45 17:15 18:30 09:30 10:45 11:00 12:45 13:15 13:45 14:15 14:30 15:45 18:30 16:15 18:45 17:00 17:15 SEPTEMBER 3

6th European Congress of Immunology, September 1-4, 2021 23 Track 3 Track Track 1 Track HALL 10 WORKSHOP- WORKSHOP- Technologies Technologies WORKSHOP - WORKSHOP Moleculer and Cellular Cellular Mechanisms Diseases and Innovative Diseases and Innovative

Track 3 Track Track 3 Track HALL 9 WS.T3.19 WS.T3.21 COVID 19 - 2 COVID genetic effects Inflammation and Inflammation Track 3 Track Track 3 Track HALL 8 WS.T3.15 WS.T3.20 and Tumor and Tumor COVID 19-3 COVID Microenvironment Immunoregulation Immunoregulation Track 3 Track Track 3 Track HALL 7 Tolerance WS.T3.10 WS.T3.04 Exploiting Host Exploiting Host T Cells in Atopy, in Atopy, T Cells Transplantation and Transplantation Interaction Pathogen Track 2 Track Track 1 Track HALL 6 WS.T2.05 WS.T1.05 Lymphocyte Lymphocyte Differentiation Immune Receptors Immune Regulation by by Immune Regulation BREAK BREAK LUNCH BREAK LUNCH Track 4 Track Track 2 Track HALL 5 WS.T2.06 WS.T4.03 Responses and Big Data - Innate Immune - Innate Immune Regulation Immune Regulation Cancer Immunotherapy Immunotherapy Cancer S4.4 S4.5 Track 4 Track Track 4 Track HALL 4 Analysis Cell Population Dynamics Population Perspectives in Single Perspectives - from Individuality to - from EFIS-IL: TCC_EUROPE: T EFIS-IL: TCC_EUROPE: Cells in High Dimension Cells S3.2 S3.4 Track 3 Track Track 3 Track System HALL 3 Cell Signaling Cell Note: All times mentioned are Central European Time European are Central All times mentioned Note: Aging of the Immune Aging

S2.5 Cells Track 2 Track Track 3 Track HALL 2 WS.T3.11 RNA and Epigenetic RNA and Epigenetic EFIS-IL: Non-Coding EFIS-IL: Non-Coding Regulation in Immune Regulation and Mucosa Microbiota

S1.2 KL.4 PL. 4 Track 1 Track Track 2 Track HALL 1 WS.T2.04 Ceremony EDIT BUZAS CEZMI AKDIS Cells Myeloid Epithelial Barrier Epithelial Hypothesis for the Hypothesis for the Immune Response Closing and Awards and Awards Closing Extracellular Vesicles Extracellular Vesicles Origins of Allergic and Origins of Allergic Autoimmune Diseases Regulation in Diseases Regulation in the Immune System 10:15 10:30 11:45 12:00 13:15 13:45 14:45 16:30 09:30 10:15 10:30 11:45 12:00 13:15 13:45 15:00 SEPTEMBER 4

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Scientific Program

ECI 2021 Tracks The scientific program of the ECI 2021 is structured into four tracks: Track 1: Cellular Immunology Track 2: Molecular Immunology Track 3: Diseases and Immune Responses Track 4: Innovative Technologies and Immunotherapies

How to read the presentation numbers WS.T1.03: WS stands for one of the following session types

KL: Keynote Lecture PL: Plenary Lecture MS: Main Symposium S: Symposium JS: Joint Symposium BS: Bright Spark WS: Workshop BP: Best Poster Session

WS.T1.03: T(digit) stands for one of the following tracks: Track 1: Cellular Immunology Track 2: Molecular Immunology Track 3: Diseases and Immune Responses Track 4: Innovative Technologies and Immunotherapies

WS.T1.03: 03 indicates the chronological order of sessions within the respective track Thus, WS.T1.03 indicates the third session of Track 1. Please note Track 3 has 22 sessions.

ECI 2021 Organizing Committee also included 2 additional workshop sessions with late submitted abstracts combining 2 tracks together and named them “Workshop - Molecular and Cellular Mechanisms” and “Workshop - Diseases and Innovative Technologies”. You will find them under Track 1 and Track 3.

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Invited Program

Keynote and Plenary Lectures The keynote lectures are the most prestigious sessions of the congress. There are four keynote lecturers of which two are Nobel Laureates. Keynote lectures are scheduled on opening and closing days of the congress. There are four plenary lectures whose speakers are among the most renowned in their field of expertise on the second, third and last days of the congress.

Main and Regular Symposia The symposia are part of the 4-track program and are state-of the art educational sessions in which invited speakers share their latest research findings on a given topic. There will be 10 main and 20 regular symposia sessions.

Joint Symposia Joint symposia are sessions in which the EFIS joins forces with other international scientific societies to facilitate knowledge and experience transfer and bring researchers from related disciplines and/or different continents together. It is a great networking opportunity and valuable contribution to the main scientific program. There are 15 different scientific and geographical guest societies joining ECI 2021 with 13 guest symposia.

EFIS President’s Symposium The EFIS President`s Symposium was first introduced in ECI 2018. It is organized by the current EFIS president.

Women and Men in Immunology Since 2015, ECI holds a special session entitled “Women and Men in Immunology” to discuss gender inequality issues in the immunology field and in academia in general. Upon formation of the EFIS Diversity Task Force, this year “Women and Men in Immunology” session is organized together with this task force and will focus on the impact of COVID-19 pandemic on the women immunologists. We hope to combine science, advocacy and prizes in this special session which will include a brief prize ceremony of the Işıl Berat Barlan Awards.

yEFIS – Young EFIS Task Force Symposium yEFIS session is a brand new session launching for the first time at ECI 2021. It is organized and coordinated by the yEFIS Task Force, a group working to bring together all early career scientists in the field of immunology, to build an effective network within Europe.

Expert’s Guide to Publishing This year’s Expert’s Guide to Publishing workshop, organized by Wiley will share insights on how to get published and research ethics in academia. Topics will include preparing manuscripts, peer review and understanding research ethics and integrity.

Pre-Congress Educational Meeting ECI 2021 offers courses / educational sessions on related topics. These are meetings beingof interest to the general ECI audience, scheduled on August 31st. However, participants must register in advance. More information can be found on page 26.

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Submitted Program Bright Sparks Workshops The most notable and exciting work from abstracts submitted to the congress by early career scientists are honored with an oral presentation in one of the Bright Sparks Workshops. Bright Sparks sessions are planned as live sessions. Presenters are expected to explain their work and answer questions from the audience. The awardees for the BioLegend Bright Sparks Awards will be chosen from those presentations.

Workshops The most notable and exciting work from all abstracts submitted to the congress are honored with an oral presentation in these sessions. Workshop sessions will include pre-recorded presentations with a live connection for discussion where presenters will be asked to participate real time and answer questions from the audience about their work.

Best Poster Sessions Special to the virtual ECI 2021, there will be “Best Poster Sessions” included in the main scientific program. The Scientific Program Committee shortlisted most notable poster abstracts. The Best Poster Jury evaluated these shortlisted poster presentations, and selected poster award candidates who will be invited for “Best Poster Sessions”. Similar to workshop sessions, best poster sessions also include pre-recorded presentations with a live connection for discussion.Best Poster Session chairs will then evaluate and make the final decision on winners in each session. Best Poster Awards will be chosen from those presentations.

NEW THIS YEAR – Interactive Lounge Sessions 30 or 60 minute interactive sessions are live video meeting rooms where maximum of200 participants can join in an interactive discussion on various topics. These sessions will take place in the ‘’Interactive Session Rooms’’ on the platform.

Sponsored Program Industry Sponsored Sessions Industry Sponsored Sessions are organized by the corporate sponsors of the Congress and are approved by the Scientific Program Committee. The content of the presentations are sponsor company’s responsibility. ECI Organizers does not endorse any of the content of these symposia. See detailed information on page 89.

Pre-Congress Educational Meetings Tuesday, August 31, 2021 09:15 – 17:40 Inborn Errors Immunity: An Expanding Spectrum of Clinical Phenotypes 10:00 – 15:30 Advanced Flow Cytometry: Taking Cytometry to the Next Dimension 15:00 – 20:00 An Update in Immune Mechanisms and Novel Therapeutic Approaches in Rheumatology These meetings will take place on the virtual congress platform but require separate registration.

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Scientific Satellite Meetings Satellite Symposium of the Research Focus Group Neuroendocrinoimmunology of the German Society for Immunology (AKNEI) Tuesday, August 31, 2021 / 15:00-18:30 CET Platform: Zoom This meeting takes place independent from the virtual congress platform.

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Keynote and Plenary Lectures

Wednesday, September 1, 2021 10:00 – 11:00 HALL 1

KL.1 How Cells Sense and Respond to Oxygen Depletion Peter J. RATCLIFFE, United Kingdom Chairs: Gunnur DENIZ, Turkey & Andreas RADBRUCH, Germany Sir Professor Peter J. Ratcliffe will present live and answer questions from the audience in real time.

14:30 – 15:30 HALL 1

KL.2 Story of How Innate Immune Cells Sense Danger and Respond to It Jules HOFFMAN, France Chairs: Ihsan GURSEL, Turkey & Federica SALLUSTO, Switzerland Proffesor Jules Hoffman will join live for question and answers after his pre- recorded prensentation.

19:00 – 20:00 HALL 1

KL.3 Environmental Influences on Intestinal Immune Responses and Epithelial Cell Homeostasis Brigitta STOCKINGER, United Kingdom Chairs: Mark COLES, United Kingdom & Faith OSIER, United Kingdom Professor Brigitta Stockinger will present live and answer questions from the audience in real time.

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Saturday, September 4, 2021 13:45 – 14:45 HALL 1 KL.4 Epithelial Barrier Hypothesis for the Origins of Allergic and Autoimmune Diseases Cezmi AKDIS, Switzerland Chairs: Marieke VAN HAM, The Netherlands & Miodrag LUKIC, Serbia Professor Cezmi Akdis will present live and answer questions from the audience in real time.

Thursday, September 2, 2021 09:30 – 10:15 HALL 1 PL.1 Human T Cells in Health and Disease Federica SALLUSTO, Switzerland Chairs: Silke APPEL, Norway & Pablo ENGEL, Spain Professor Federica Sallusto will present live and answer questions from the audience in real time.

10:30 – 11:15 HALL 1 PL.2 Single Cell Omics and a Pandemic: Did We Learn Something that Helps Us for Other Diseases As Well? Joachim SCHULTZE, Germany Chairs: Luca VANNUCCI, Czech Republic & Sarah TEICHMANN, United Kingdom Professor Joachim Schultze will present live and answer questions from the audience in real time

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Friday, September 3, 2021 16:15 – 17:00 HALL 1

PL.3 Damage, Defense and Adaptation – How the Immune System Ages Janko NIKOLICH-ZUGICH, USA Chairs: Djordje MILJKOVIC, Serbia & Clare BRYANT, United Kingdom Professor Janko Nikolich-Zugich will present live and answer questions from the audience in real time.

Friday, September 4, 2021 09:30 – 10:15 HALL 1

PL.4 Extracellular Vesicles in the Immune System Edit BUZAS, Hungary Chairs: Christine FALK,Germany & Marco Antonio CASSATELLA, Italy Professor Edit Buzas will present live and answer questions from the audience in real time.

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Scientific Program by Day Wednesday, September 1, 2021

Opening Ceremony 09:30 – 10:00 | HALL 1 KL.1 How Cells Sense and Respond to Oxygen Depletion 10:00 – 11:00 | HALL 1 Peter J. RATCLIFFE, United Kingdom Chairs: Gunnur DENIZ, Turkey & Andreas RADBRUCH, Germany S1.1 - Latest Insight on B Cell Effector Functions 11:15 – 12.30 | HALL1 Chairs: Marjolein van EGMOND, The Netherlands & Guher SARUHAN DIRESKENLI, Turkey Dissecting Human in vitro Plasma Cell Differentiation Routes Using Single-Cell RNA Sequencingw Marieke Van HAM, The Netherlands Regulatory Plasma Cells: Identification & Therapeutic Utilization Simon FILLATREAU, France Unravelling Novel Aspects of the Cell Biology of Plasma Cells Marion ESPELI, France S2.1 - Microbiota and the Immune System 11:15 – 12:30 | HALL 2 Chairs: Eva SVERREMARK-EKSTRÖM, Sweden & Ayca SAYI YAZGAN, Turkey The Gut Environment as An Instructor for Immune Maturation and Function Eva SVERREMARK - EKSTROM, Sweden Secretory Antibodies in the Intestinal Ecosystem Emma SLACK, Switzerland Probing Tissue Macrophage Functions Steffen JUNG, Israel S3.1 - Immunometabolism 11:15 – 12:30 | HALL 3 Chairs: Hannes STOCKINGER, Austria & Guadalupe SABIO, Spain Generating and Maintaining Tissue Resident T Cells Marc VELDHOEN, Portugal IFNß is a Novel Effector Cytokine in Resolving Inflammation and skin fibrosis Amiram ARIEL, Israel Regulatory Interaction Between Iron Homeostasis, Innate Immune Function and Infections Guenter WEISS, Austria S4.1 - Visualizing Lymphocytes Signaling 11:15 – 12:30 | HALL 4 Chairs: Balbino ALARCON, Spain & Loredana SAVEANU, France Endosomal Signaling via ITAM Coupled Immune Receptors Loredana SAVEANU, France Intracellular Traffic of Signaling Proteins: How does it Affect T Cell Activation? Claire HIVROZ, France Using Synthetic Biology to Understand Immune Signalling Erdinç SEZGİN, Sweden

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Workshop - TRACK 4 WS.T4.01 - Bioinformatics and Immunology 11:15 – 12:30 | HALL 5 Chairs: Victor GREIFF, Norway & Charlotte SCOTT, Belgium The hidden stage of V(D)J-recombination: examination of the first time discovered human TRB D1-D2 rearrangements repertoires Alexander Y Komkov, Anastasia O Smirnova, Dmitriy M Chudakov, Ilgar Z Mamedov, Russia Using Spatial Proteogenomics to create a practical cell atlas of the murine and human liver Liesbet Martens, Tinne Thoné, Bart Vanderborght, Birthe Haest, Johnny Bonnardel, Anna Bujko, Robin Browaeys, Bavo Vanneste, Tineke Vanhalewyn, Yvan Saeys, Bart Deplancke, Wouter Saelens, Hans Van Vlierberghe, Lindsey Devisscher, Martin Guilliams, Charlotte L. Scott, Belgium Personalized molecular portraits of Systemic Lupus Erythematosus patients as key for prognosis and therapeutic decisions Daniel Toro Domínguez, Raúl López Domínguez, Guillermo Barturen, Pedro Carmona Sáez, Marta Eugenia Alarcón Riquelme, Spain IgTreeZ: A toolkit for immunoglobulin gene lineage tree analysis Hadas Neuman, Ramit Mehr, Israel Single-cell RNA sequencing reveals striking heterogeneity of mononuclear phagocytes in bovine mesenteric lymph nodes G. Tuba Barut, Marco Kreuzer, Rémy Bruggmann, Artur Summerfield,Stephanie C. Talker, Switzerland Pan-cancer survey of tumour mass dormancy and underlying mutational processes Anna Julia Wiecek, Daniel Hadar Jacobson, Wojciech Lason, Maria Secrier, United Kingdom Investigating the role of multicomponent multitarget drug Tr14 in inflammation resolution using in silico perturbation experiments Suchi Smita Gupta, Matti Hoch, Moritz Kunzmann, Konstantin Cesnulevicius, David Lescheid, Myron Schultz, Olaf Wolkenhauer, Shailendra Gupta, Germany

Workshop - TRACK 1 WS.T1.03 - Innate Immunity 11:15 – 12:30 | HALL 6 Chairs: Sylvia KNAPP, Austria & Sebastian AMIGORENA, France Deciphering the role of cDC2 in Sjögren’s Syndrome: transcriptomic profile reveals an enhanced antigen uptake and altered antigen processing associated with IFN-signature Ana Lopes, Maarten Hillen, Anneline Hinrichs, Sofie Blokland, Cornelis Bekker, Aridaman Pandit, Aike Kruize, Timothy Radstake, Joel Van Roon, Netherlands Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation Jan Dudeck, Johanna Kotrba, Roland Immler, Markus Sperandio, Anne Dudeck, Germany MC-derived TNF is crucial for resolution of skin inflammation and tissue remodeling Martin Voss, Konstantinos Katsoulis Dimitriou, Anne Dudeck, Germany Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells Mihai Valache, Laura Marongiu, Francesca Mingozzi, Clara Cigni, Roberta Marzi, Marco Di Gioia, Massimiliano Garrè, Dario Parazzoli, Laura Sironi, Maddalena Collini, Reiko Sakaguchi, Takashi Morii, Mariacristina Crosti, Monica Moro, éSt phane Schurmans, Tiziano Catelani, Rany Rotem, Miriam Colombo, Stephen Shears, Davide Prosperi, Ivan Zanoni, Francesca Granucci, Italy

6th European Congress of Immunology, September 1-4, 2021 33 Wednesday, September 1, 2021

Investigating the molecular and functional interaction between human macrophages and HiPSC- derived cardiomyocytes by an in vitro arrhythmia model Arzuhan Koç, Celal Akdeniz, Esra Çağavi, Turkey Bacterial lysate enhances protective mucosal immunity via increased expression of antimicrobial peptides Giacomo Sidoti Migliore, Stefania Campana, Chiara Barberi, Claudia De Pasquale, Paola Orecchia, Giovanna Ginestra, Giuseppina Mandalari, Genny Del Zotto, Paolo Carrega, Maria Cristina Mingari, Guido Ferlazzo, Italy Inflammation induces CCR5-positive pro-NETotic neutrophils via TNFR2 signaling Friederike Neuenfeldt, Jan Christoph Schumacher, Ricardo Grieshaber Bouyer, Jüri Habicht, Jutta Schröder Braunstein, Annika Gauss, Beate Niesler, Alexander Dalpke, Matthias M. Gaida, Thomas Giese, Stefan Meuer, Yvonne Samstag, Guido Wabnitz, Germany

Workshop - TRACK 2 WS.T2.02 - Immune Regulation and Transcriptional Modulation 11:15 – 12:30 |HALL 7 Chairs: Iva Hafner BRATKOVIČ, Slovenia & Magdalena HUBER, Germany Sibling rivalry among the ZBTB transcription factor family: homo vs heterodimerization Sofia Piepoli, Umit Akkose, Liyne Noğay, Hakan Taşkiran, Nazife Tolay, Melike Gezen, Ogun Adebali, Canan Atilgan, Batu Erman, Turkey MNDA controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7 Lili Gu, David Casserly, Gareth Brady, Susan Carpenter, Katherine A Fitzgerald, Andrew G Bowie, Ireland Foxp3-specific deletion of CREB generates Th2 biased ST-2 positive regulatory T-cells with enhanced IL-10 production and suppressive capacity Kim Ohl, Sudheendra Hebbar Subramanyam, Thomas Look, Eva Verjans, Svenja Böll, Ivan Costa, Stefan Floess, Jochen Huehn, Tobias Bopp, Bart Lambrecht, Martin Zenke, Klaus Tenbrock,Germany The molecular interplay of Ets-2-Tip60 and its role in the pathogenesis of multiple sclerosis (MS) Ioanna Aggeletopoulou, Ioannis Panagoulias, Panagiota Davoulou, Constantinos Kilidireas, Athanasia Mouzaki, Greece HMGCR gene polymorphisms (rs33761740, rs3846662) and promoter DNA methylation association with serum lipids in coronary artery disease Nivas Shyamala, Krishna Reddy Nallamala, Surekha Rani Hanumanth, India Organ-specific inflammation-driven changes in the epigenetic signature of murine ILC2s Chia Wen Lu, Michael Beckstette, Anna Ntalli, Aaron Ochel, Friederike Kruse, Beate Pietzsch, Katrin Neumann, Jochen Huehn, Stefan Floess, Matthias Lochner, Germany The transcription factor BATF limits the expression of type I interferon in plasmacytoid dendritic cells Shafaqat Ali, Ritu Mann Nüttel, Regine Dress, Patrick Petzsch, Karl Ehrich Köhrer, Haifeng Chris Xu, Philipp Lang, Judith Alferink, Stefanie Scheu, Germany

6th European Congress of Immunology, September 1-4, 2021 34 Wednesday, September 1, 2021

Workshop - TRACK 4 WS.T4.05 - Vaccines in Immunotherapy 11:15 – 12:30 | HALL 8 Chairs: Kingston MILLS, Ireland & Milan RASKA, Czech Republıc Phosphonated cellulose nanocrystals potentiate Th1 polarizing capacity of monocyte-derived dendritic cells Marina Bekić, Miloš Vasiljević, Vanja Kokol, Dušan Mihajlović, Dragana Vučević, Miodrag Čolić, Sergej Tomić, Serbia Liposomal vitamin D3 and retinoic acid induce tolerogenic dendritic cells Noémi Anna Nagy, Fernando Lozano Vigario, Toni M. M. Van Capel, Rinske Sparrius, Teunis B. H. Geijtenbeek, Ronald Van Ree, Sander W. Tas, Bram Slütter, Esther C. De Jong, Netherlands Cytomegalovirus vector expressing NKG2D ligand generates superior CD8 T cell response with distinct phenotypical and functional features Marko Šustić, Maja Cokarić Brdovčak, Berislav Lisnić, Materljan Jelena, Indenbirken Daniela, Ilija Brizić, Krmpotić Astrid, Jonjić Stipan, Croatia Immunotherapy-on-chip against an experimental sepsis model Ioanna Zerva, Bakela Katerina, Athanassakis Irene, Greece Mucosal administration of polyethylenimine in formulation with SARS-SoV-2 spike elicits potent neutralising responses Lachlan Paul Deimel, Xiaochao Xue, Adam Harding, Javier Gilbert Jaramillo, Quentin James Sattentau, United Kingdom Probing the importance of valency and spatial organization of immune regulator PD-1 with DNA-based nanomaterials Jorieke Weiden, Kaltrina Paloja, Alice Comberlato, Cem Tekin, Maartje M.c. Bastings, Switzerland Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles via IL-1 and IL-18- driven Th1 and CD8 T cell responses Natalia Muñoz Wolf, Ross W. Ward, Emma Creagh, Yvonne Perrie, Ed C. Lavelle, Ireland

Workshop - TRACK 3 WS.T3.01 - Allergy and Asthma 11:15 – 12:30 | HALL 9 Chairs: Aleksandra POPOV ALEKSANDROV, Serbia & Ariel MUNITZ, Israel Oral administration of short chain fatty acids to PBMC-engrafted humanized mice prevents allergen- dependent airway and intestinal inflammation Robert Ose, Benno Weigmann, Stephan Sudowe, Detlef Schuppan, Joachim Saloga, Iris Bellinghausen, Germany Hypoxia ameliorates allergic asthma in vivo by interfering with immune cell cross-talk Mathias Hochgerner, Eva Sturm, Grazyna Kwapiszewska, Horst Olschewski, Leigh M Marsh, Austria Characterisation of allergen-specific B cell tolerance in children with cow’s milk-oral immunotherapy and natural outgrow of milk allergy Pattraporn Satitsuksanoa, Willem Van De Veen, Ge Tan, Oliver Wirz, Milena Sokolowska, Irish Chang, Kari Nadeau, Mübeccel Akdis, Switzerland In depth analysis of the bee venom allergen-specific B cell repertoire in immunotherapy-treated venom allergic individuals and naturally exposed healthy beekeepers Willem Van De Veen, Ramona A Hoh, Ji Yeun Lee, David Mirer, Monique Daanje, Mirelle Kleuskens, Hergen Spits, Scott D Boyd, Mübeccel Akdis, Switzerland

6th European Congress of Immunology, September 1-4, 2021 35 Wednesday, September 1, 2021

Asthma-associated immunological responses in RSV infections on primary human lung tissue ex vivo Mareike Ahrends, Olga Danov, Christopher Werlein, Eike Preuss, Patrick Zardo, Danny Jonigk, Sabine Wronski, Christina Hesse, Armin Braun, Katherina Sewald, Germany The major peanut allergens Ara h 1, 2, 3 and 6 are taken up by dendritic cells via different routes and receptors Charlotte Castenmiller, Brigitte Carole Keumatio Doungtsop, Sven Bruijns, Joost Smits, Ronald Van Ree, Stef Koppelman, Esther Christina De Jong, Yvette Van Kooyk,Netherlands Mast cell chymase affects the functional properties of primary human lung fibroblast: implications for asthma Xinran Zhao, Maria Lampinen, Ola Rollman, Christian Sommerhoff, Aida Paivandy, Gunnar Pejler, Sweden

Workshop - TRACK 3 WS.T3.03 - Molecular Mechanisms of Inflammation 11:15 – 12:30 | HALL 10 Chairs: Nemanja JOVICIC, Serbia & Arzu ARAL, Turkey Assessment of changes in the expression of immunomodulatory miRNAs (miR-20b, miR-155 and miR- 221) in workers occupationally exposed to Cadmium Prasenjit Mitra, Taru Goyal, Shailja Sharma, Praveen Sharma, India Anti-inflammatory effect of Crocus sativus extract evaluated in a murine model of osteoarthritis Blagovesta Boneva, Nikola Ralchev, Petya Ganova, Andrey Tchorbanov, Nikolina Mihaylova, Bulgaria Regulation of IL-36 receptor driven skin in inflammation in psoriasis Yasmina Esther Hernández Santana, Gemma Leon, Erini Giannoudaki, David St Leger, Ania M Stefanska, Hazel Lawler, Alberto Mantovani, Cecilia Garlanda, Padraic G Fallon, Patrick T Walsh, Ireland A novel role for nutrient receptors in cartilage and joint disease Lauren E. Fagan, James O. Early, Richard G. Carroll, Cathal J. Kearney, Oran D. Kennedy, Annie M. Curtis, Ireland Glycolysis is a key driver of tissue degradation and remodelling in tuberculosis Radha Asher, Daniela Kirwan, Sandra Ashton, Robert Gilman, Nitya Krishnan, Brian Robertson, Jonathan Friedland, United Kingdom Liver X receptor activation promotes intestinal repair while limiting tumorigenesis Srustidhar Das, Sara Martina Parigi, Sandra Scharaw, Xinxin Luo, Oscar Eduardo Diaz, Anna Webb, Chiara Zagami, Penelope Pelczar, Marjorie De La Fuente, Paulo Czarnewski, Francisco López Köstner, Susanne Nylén, Per Antonson, Marcela A. Hermoso, Samuel Huber, Jan Åke Gustafsson, Pekka Katajisto, Eduardo J. Villablanca, Sweden C5aR2 deficiency ameliorates inflammation in antibody transfer-experimental epidermolysis bullosa acquisita and reveals promoting of C5aR1 signaling outcomes Daniel Leonard Seiler, Marie Kleingarn, Jovan Schanzenbacher, Elvira Ehlers Jeske, Christian D Sadik, Enno Schmidt, Katja Bieber, Jörg Köhl, Ralf Ludwig, Christian Marcel Karsten, Germany

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JS - Joint Symposium with The European Alliance of Associations of Rheumatology (EULAR) Single Cell Rheumatology 13:00 – 14:15 | HALL 1 Chairs: Koen VENKEN, Belgium & Mariola KUROWSKA STOLARSKA, United Kingdom Novel Tools in Single Cell RNAseq to Unravel Immunobiology: Zooming in on Macrophage Biology Martin GUILLIAMS, Belgium Delineating Macrophage Subsets by Single Cell RNA Seq in Rheumatoid Arthritis Mariola KUROWSKA – STOLARSKA, United Kingdom Fibroblast Subsets in Arthritis Chris BUCKLEY, United Kingdom Synovial T Cells in JIA Mir-Farzin MASHREGHI, Germany

JS - Joint Symposium with The International Union of Immunological Societies (IUIS)

COVID Vaccines and Immunity 13:00 – 14:15 | HALL 2 Chairs: Ursula WIEDERMANN SCHMIDT, Austria & Ed LAVELLE, Ireland Similarities and Differences of COVID-19 Vaccines Franz X. HEINZ, Austria Covid Vaccination in the United Kingdom: from the Development to Efficiacy Evaulation of COVID Vaccines Andrew POLLARD, United Kingdom How Long will Vaccine Induced Protection Last – Are Regular Booster Necessary? Bali PULENDRAN, USA

JS - Joint Symposium with The European Academy of Allergy and Clinical Immunology – EAACI The Immune Challenge of COVID-19 Infection for Allergic Patients 13:00 – 14:15 | HALL 3 Chairs: Aslı GELINCIK, Turkey & Stefano DEL GIACCO, Italy The Immune Response to COVID-19 Infection and to COVID-19 Vaccines in Type-2 Allergic Diseases Cezmi AKDIS, Switzerland Biologicals for Allergic Diseases and Asthma, COVID-19 Infection and COVID-19 Vaccines Ioana AGACHE, Romania Allergen Immunotherapy, COVID-19 Infection and COVID-19 Vaccines Marek JUTEL, Poland

6th European Congress of Immunology, September 1-4, 2021 37 Wednesday, September 1, 2021

JS - Joint Symposium with The European Federation of Immunogenetics – EFI Immunogenetics of Cancer 13:00 – 14:15 | HALL 4 Chairs: Lotte WIETEN, The Netherlands & Mirjam HEEMSKERK, The Netherlands Immunogenetics of the MHC and NK Cell Receptors John TROWSDALE, United Kingdom Immunogenetics of Leukemia Luca VAGO, Italy Immunogenetics of Cancer Therapy Lotte WIETEN, The Netherlands

JS - Joint Symposium with The Japanese Society of Immunology – JSI Immunosensing and Antiviral Immunity 13:00 – 14:15 | HALL 5 Chairs: Osamu TAKEUCHI, Japan & Cevayir COBAN, Japan Nucleside-Sensing by Toll-like Receptor 7 and 8 Kensuke MIYAKE, Japan Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts Satoshi UEMATSU, Japan Antiviral Immunity and Its Regulation by RNA Binding Proteins Osamu TAKEUCHI, Japan

JS - Joint Symposium with the European Society of Immunodeficiencies – ESID Human Inborn Errors of Major Pathways in Immunology: Experiments of Nature 13:00 – 14:15 | HALL 6 Chairs: Isabelle MEYTS, Belgium & Yildiz CAMCIOGLU, Turkey JAK-STAT Pathway: Overview and Inborn Errors Anne PUEL, France Cytoskeleton Dynamics and Related Inborn Errors Fabio CANDOTTI, Switzerland Human Type 1 Interferonopathies Yanick CROW, United Kingdom

JS - Joint Symposium of German Society of Immunology (DGFI) & Australian and New Zealand Society of Immunology (ASI)

Intercontinental T Cell Immunology 13:00 – 14:15 | HALL 7 Chairs: Antje BLUMENTHAL, Australia & Christian KURTS, Germany

6th European Congress of Immunology, September 1-4, 2021 38 Wednesday, September 1, 2021

CD226 a Key Regulator of T Cell Funciton Tobias BALD, Germany Comprehensive 3D Imaging and Topological Mapping of Lymphatic Labyrinths in Whole Lymph Nodes Inken KELCH, New Zealand Immune Responses to Severe COVID-19 Leif Erik SANDER, Germany Targeting of Precursors of Exhausted T Cells to Improve Immunity to Chronic Viral Infections and Cancer Daniel UTZSCHNEIDER, Australia

JS - Joint Symposium with the Russian Society of Immunology – RSI Early Stage Career Russian Scientists Joint Session 13:00 – 14:15 | HALL 8 Chairs: Winfried PICKL, Austria & Hannes STOCKINGER, Austria Analysing the Molecular IgE Reactivity Profile of Russia by Microarray Technology Olga ELISYUTINA, Russia Characterization of a B Cell Epitope-Based Vaccine for Birch Pollen Allergy Igor SHILOVSKI, Russia Engineering of a Molecular Vaccine for Treatment of Cat and Dog Allergy Ksenja RIABOVA, Russia The Role of Th1 and Th2 Immunity in Rhinovirus Infections Alexandra NIKONOVA, Russia Tracing Cells Producing Allergen-Specific IgE in Allergic Patients Maria BYAZROVA, Russia Therapeutic Vaccination against Hepatitis B Inna TULAEVA, Austria

Workshop - TRACK 3 WS.T3.02 - Cellular Mechanism of Inflammation 13:00 – 14:15 | HALL 9 Chairs: Amiram ARIEL, Israel & Gaye ERTEN YURDAGUL, Turkey Determinants of susceptibility in mice infected with mouse-adapted SARS-CoV-2 Riem Gawish, Philipp Starkl, Lisabeth Pimenov, Anastasiya Hladik, Karin Lakovits, Anna Ohradanova Repic, Sylvia Knapp, Austria Neuroimmune Cardiovascular Interfaces in Atherosclerosis Sarajo Mohanta, Li Peng, Yuanfang Li, Changjun Yin, Shu Lu, Ting Sun, Lorenzo Carnevale, Marialuisa Perrotta, Jaroslav Pelisek, Benjamin Förstera, Ali Ertürl, Piotr Szczepaniak, Remco Megens, Livia Habenicht, Giuseppe D´agostino, Thomas Guzik, Peder Olofsson, Ali Ertürk, Thomas Mettenleiter, Christian Weber, Giuseppe Lembo, Daniela Carnevlae, Andreas Habenicht,Germany Infiltrating neutrophils present an aged phenotype and an altered recruitment dynamics and functionallity in chronic liver disease Silvia Ariño, Beatriz Aguilar Bravo, Mar Coll, Woo Yong Lee, Paul Kubes, Pau Sancho Bru, Spain

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CD69 expression on regulatory T cells protects from immune-mediated damage after myocardial infarction Rafael Blanco Dominguez, Hortensia De La Fuente, Cristina Rodríguez, Iker Rodriguez Arabaolaza, Raquel Sánchez Díaz, Rosa Jiménez Alejandre, Laura Martín Aguado, Fernando Alfonso, Francisco Sánchez Madrid, José Martínez González, Pilar Martín, Spain Colchicine limited secondary lung injury in an experimental rat sepsis model Mehmet Ceylan, Hüseyin Oğuz Yılmaz, Safiye Aktaş, Osman Yılmaz, Şükran Köse, Turkey Critical role of resident M2-like macrophages in healthy subcutaneous adipose tissue expansion Milica Vujičić, Isabella Broderick, Pegah Salmantabar, Ingrid Wernstedt Asterholm, Sweden The role of interleukin-6 in pathogenesis of apical periodontitis studied by flow cytometry and cell cultures Tanja Džopalić, Sergej Tomić, Marina Bekić, Dragana Vučević, Dušan Mihajlović, Mile Eraković, Miodrag Čolić, Serbia

Workshop - TRACK 3 WS.T3.05 - Genetic and Environmental Triggers of Autoimmunity 13:00 – 14:15 | HALL 10 Chairs: Anna SEDIVA, Czech Republic & Marta SZELL, Hungary Identification and mapping of distinct human lymph node stromal cell subsets by combining single cell RNA sequencing with spatial transcriptomics Cristoforo Grasso, Catarina Gago De Graça, Johanna Semmelink, Ester Remmerswaal, Perry Moerland, Lisa G. M. Van Baarsen Jongejan, Reina Mebius, Lisa Van Baarsen, Netherlands cGAS-STING-dependent interferon signalling in a mitochondrial disease Alice Lepelley, Erika Della Mina, Erika Van Nieuwenhove, Lise Waumans, Sylvie Fraitag, Gillian I Rice, Ashish Dhir, Carine Wouters, Brigitte Bader Meunier, Yanick J Crow, France Preferential induction of brain-homing T-bet+ B cells by infectious triggers in multiple sclerosis patients Jamie van Langelaar, Annet F. Wierenga-Wolf, Johnny P.A. Samijn, Liza Rijvers, Marie-José Melief, Theodora A. Siepman, Pieter A. van Doorn, Helga E. de Vries, Peter-Paul Unger, S. Marieke van Ham, Joost Smolders, Marvin M. Van Luijn, The Netherlands Lung functioning and inflammation in a mouse model of systemic juvenile idiopathic arthritis Bert Malengier Devlies, Tatjana Decaesteker, Kaat Dekoster, Arno Vanstapel, Kourosh Ahmadzadeh, Fariba Poosti, Tania Mitera, Laura Seldeslachts, Erik Verbeken, Carine Wouters, Greetje Vande Velde, Jeroen Venoirbeek, Patrick Matthys, Belgium EGR2 and EGR3 prevent uncontrolled accumulation of B1 and CD21low age-associated B cells Etienne Masle Farquhar, Timothy Peters, Christoph Weigel, Christopher Oakes, Joanne Reed, Christopher Goodnow, Australia Functional monovalency of IgG4 autoantibodies amplifies their pathogenicity in MuSK myasthenia gravis Dana L. Vergoossen, Jaap J. Plomp, Christoph Gstöttner, Yvonne E. Fillie Grijpma, Roy Augustinus, Robyn Verpalen, Manfred Wuhrer, Paul W Parren, Elena Dominguez Vega, Silvere M Van Der Maarel, Jan J Verschuuren, Maartje G Huijbers, The Netherlands Characterising the relation between genetic background and gut immune response against microbiota in a murine model of lupus María Botía Sánchez, Georgina Galicia, Marta E. Alarcón Riquelme, Spain

6th European Congress of Immunology, September 1-4, 2021 40 Wednesday, September 1, 2021

KL.2 Story of How Innate Immune Cells Sense Danger and Respond to It 14:30 – 15:30 | HALL 1 Jules HOFFMAN, France Chairs: Ihsan GURSEL, Turkey & Federica SALLUSTO, Switzerland

MS1.1 – T Cell Regulation 16:00 – 17:30 | HALL 1 Chairs: Riitta LAHESMAA, Finland & Ann AGER, United Kingdom Molecular Mechanisms of Human T Cell Differentiation Riitta LAHESMAA, Finland Control of Immune Responses by Regulatory T Cells Shimon SAKAGUCHI, Japan Origin, Effector Function, and Immunopathology Driving Potential of CD8 T Cells with or without an Exhausted Phenotype Dietmar ZEHN, Germany

MS2.1 – Immunomodulation and Aging 16:00 – 17:30 | HALL 2 Chairs: Megan MACLEOD, United Kingdom & Doron MELAMED, Israel How can We Predict Vaccine Responsiveness in Older Adults? Graham PAWELEC, Germany Altered Cellular Interaction Leading to Decreased Immunity During Ageing Arne AKBAR, United Kingdom Role of Autophagy in Immune Aging Anna Katharina SIMON, United Kingdom

MS3.1 – Mucosal Immune Response 16:00 – 17:30 | HALL 3 Chairs: Kingston MILLS, Ireland & Carolina CONSTANTIN, Romania The Role of IL-17-Secreting Tissue-Resident Memory CD4 T Cells in Protection Against Bordetella Pertussisinfection of the Nasal Mucosae Kingston MILLS, Ireland A Crystal View on Mucosal Type 2 Immunity in Asthma Bart LAMBRECHT, Belgium Gut Immune Responses: What have We Learnt from Celiac Disease? Ludvig SOLLID, Norway

MS4.1 – Immunological Mechanisms in Allergic Diseases and Immunotherapy 16:00 – 17:30 | HALL 4 Chairs: Erika JENSEN-JAROLIM, Austria & Mübeccel AKDIS, Switzerland Novel B Cell Subsets and their Role in Immune Regulation Mübeccel AKDIS, Switzerland Prophylactic Vaccination of Allergy Rudolf VALENTA, Austria Novel Insights into Mechanisms and Biomarkers of Allergen Immunotherapy Mohamed SHAMJI, United Kingdom

6th European Congress of Immunology, September 1-4, 2021 41 Wednesday, September 1, 2021

Bright Sparks Workshop - TRACK 4 BS.T4.01 - Vaccines and Immunotherapies 16:00 – 17:15 | HALL 5 Chairs: Agata MLYNSKA, Lithuania & Ihsan GURSEL, Turkey TLR9 and STING ligands encapsulated into pH sensitive liposomes protected mice against melanoma tumor growth by elevating Th-1 immune response, Banu Bayyurt Kocabas, Kubra Almacioglu, Gozde Gucluler, Esin Alpdundar Bulut, Gizem Tincer, Mayda Gursel, Ihsan Gursel, Turkey PROTAC-mediated antigen degradation: A novel strategy to enhance CTL responses against cancer Gunja Mishra, Daryl Geers, Jane Sa Voerman, Laura Mezzanotte, Christopher Schliehe, Netherlands Inefficient CAR-proximal signaling blunts antigen sensitivity Venugopal Gudipati, Julian Rydzek, Iago Doel Perez, Vasco Dos Reis Gonçalves, Lydia Scharf, Sebastian Königsberger, Elisabeth Lobner, Renate Kunert, Hermann Einsele, Hannes Stockinger, Michael Hudecek, Johannes B Huppa, Austria Genetically engineered tolerogenic dendritic cells induce Ag-specific CD8+ T cell exhaustion and Ag- specific IL-10-produding T cells and modulate Type 1 Diabetes in vivo Laura Passeri, Ilaria Marrocco, Cecilia Laudisa, Luca Cesana, Fabio Russo, Andrea Annoni, Silvia Gregori, Italy Inter-donor variability in dendritic cells capacity to respond to stimulation in vitro associates with donors gut microbiota composition Dušan Radojević, Sergej Tomić, Dušan Mihajlović, Maja Tolinački, Bojan Pavlović, Dragana Vučević, Svetlana Bojić, Nataša Golić, Miodrag Čolić, Jelena Đokić, Serbia The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination in humans Florian Wimmers, Michele Donato, Alex Kuo, Tal Ashuach, Shakti Gupta, Chunfeng Li, Mai Dvorak, Mariko Hinton Foecke, Sarah E. Chang, Thomas Hagan, Sanne E. De Jong, Holden T. Maecker, Robbert Van Der Most, Peggie Cheung, Mario Cortese, Steven E. Bosinger, Mark Davis, Nadine Rouphael, Shankar Subramaniam, Nir Yosef, Paul J. Utz, Purvesh Khatri, Bali Pulendran, United States

Best Poster Session - Track 1 BP.T1.01 - Cellular Immunology 16:00 – 17:15 | HALL 6 Chairs: Anita MILICIC,United Kingdom & Massimo LOCATI, Italy The Jury will make their nominations for the Best Poster session after pre-viewing of posters in the E-poster Hall. Therefore, the line up of Best Poster presenters will not be available until August 31st. You may view the line-up on the congress web platform once it is announced.

Workshop - TRACK 2 WS.T2.01 - Immune Regulation and Signaling 16:00 – 17:15 | HALL 7 Chairs: Rike BERBERICH-SIEBELT, Germany & Elizabeth BRINT, Ireland PGE2 signaling reprograms the cDC1 transcription factor network to promote cDC1 dysfunctionality in tumors and limit cancer immune control Felix Bayerl, Philippa Meiser, Anna Hirschberger, Sainitin Donakonda, Rupert Öllinger, Bernard Malissen, Caetano Reis E Sousa, Roland Rad, Barbara Schraml, Jan Böttcher, Germany

6th European Congress of Immunology, September 1-4, 2021 42 Wednesday, September 1, 2021

DDX3X Links NLRP11 to the regulation of type I interferon responses and NLRP3 inflammasome activation Ioannis Kienes, Sarah Bauer, Clarissa Gottschild, Nora Mirza, Jens Pfannstiel, Martina Schröder, Thomas Alexander Kufer, Germany Defining the rapid actions of glucocorticoids in the lung Fiona Leslie, Stephen Kershaw, Pauline Pfänder, Toryn Poolman, Chiara Francavilla, David Ray, Graham Cook, Laura Matthews, United Kingdom Functional T cell diversity drives differences in PD-1 signaling Anna S Tocheva, Myvizhi Selvan, Zeynep Gumus, Adam Mor, United States Characterizing the role of PLCγ2 in autoantibody-induced skin blistering Kata Petra Szilveszter, Ádám István Horváth, Lukács Sándor Lesinszki, Zsuzsanna Helyes, Attila Mócsai, Hungary Molecular mechanisms of NLRP3 inflammasome activation and its regulation Iva Hafner Bratkovič, Petra Sušjan, Pablo Pelegrin, Roman Jerala, Slovenia Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation Diego Angosto Bazarra, Ana Tapia Abellan, Cristina Alarcón Vila, Maria Carmen Baños, Iva Hafner Bratkovič, Baldomero Oliva, Pablo Pelegrín, Spain

Workshop - TRACK 1 WS.T1.09 - Myeloid Lineage 16:00 – 17:15 | HALL 8 Chairs: Joke DEN HAAN, The Netherlands & Sergej TOMIĆ, Serbia Distinct developmental pathways from blood monocytes generate human lung macrophage diversity Elza Evren, Emma Ringqvist, Kumar Parijat Tripathi, Natalie Sleiers, Inés Có Rives, Arlisa Alisjahbana, Jakob Michaëlsson, Anna Smed Sörensen, Johan Botling, Mikael C.I. Karlsson, Eduardo J. Villablanca, Tim Willinger, Sweden Dissecting the transcriptional control of airway macrophages: a key role for EGR2 Calum C Bain, Jack McCowan, Phoebe M Kirkwood, Frederic Fercoq, Wouter T’Jonck, Connar M Mawer, Richard Cunningham, Ananda S Mirchandani, Anna M Hoy, Gareth-Rhys Jones, Carsten G Hansen, Nik Hirani, Stephen J Jenkins, Sandrine Henri, Bernard Malissen, Sarah R Walmsley, David H Dockrell, Philippa TK Saunders, Leo M Carlin, United Kingdom Flagellin/TLR5 stimulate myeloid progenitors to enter lung tissue and to locally differentiate into macrophages Xin Lei, Jara Palomero, Iris De Rink, Tom De Wit, Martijn Van Baalen, Yanling Xiao, Jannie Borst, The Netherlands Targeting lipid droplet metabolism in tumor associated macrophages as a novel approach to target tumor progression Sophiya Tabassum Tahir Siddiqui, Hao Wu, Britta Siegmund, Rainer Glauben, Germany Identification and characterisation of Hofbauer cell progenitors in the first trimester human placenta Jake Thomas, Anna Appios, Xiaohui Zhao, Russell Hamilton, Ashley Moffett, Andrew Sharkey, Naomi Mcgovern, United Kingdom High-dimensional flow-cytometry and functional evaluation reveals enhanced potency of stem cell- derived dendritic cell bulk vaccination to boost T cell immunity Jesper Van Eck Van Der Sluijs, Diede Van Ens, Daan Heister, Jolanda Brummelman, Aastha Sareen, Anniek Van Der Waart, Nicolaas Schaap, Michel Kester, Marieke Griffioen, Mirjam Heemskerk, Joop Jansen, Harry Dolstra, Willemijn Hobo, The Netherlands

6th European Congress of Immunology, September 1-4, 2021 43 Wednesday, September 1, 2021

Molecular signature of conventional dendritic cell subtypes in COVID-19 disease Laura Marongiu, Giulia Protti, Fabio Facchini, Mihai Valache, Francesca Mingozzi, Valeria Ranzani, Anna Rita Putignano, Lorenzo Salviati, Valeria Bevilacqua, Serena Curti, Mariacristina Crosti, Mariella D’angiò, Laura Rachele Bettini, Andrea Biondi, Luca Nespoli, Nicolò Tamini, Nicola Clementi, Nicasio Mancini, Sergio Abrignani, Roberto Spreafico, Francesca Granucci, Italy

Workshop - TRACK 1 WS.T1.06 - Immune Response Regulation: Cellular Mechanism 16:00 – 17:15 | HALL 9 Chairs: Marcos LOPEZ HOYOS, Spain & Djordje MILJKOVIC, Serbia Role of purinergic signaling in regulating IL-1alpha mediated inflammation in chronic kidney disease Maryam Amini, Priska Jost, Janina Frisch, Stefan Schunk, Jutta Engel, Leticia Prates Roma, Thimoteus Speer, Barbara A. Niemeyer, Dalia Alansary, Germany Cell-derived vesicles present in human milk dampen innate and adaptive immune responses and enhance epithelial barrier function Marijke Zonneveld, Martijn Van Herwijnen, Marcela Fernandez Gutierrez, Alberta Giovanazzi, Anne Marit De Groot, Marije Kleinjan, Toni Van Capel, Alice Sijts, Leonie Taams, Johan Garssen, Esther De Jong, Michiel Kleerebezem, Esther Nolte ’t Hoen, Frank Redegeld, Marca Wauben, The Netherlands Mast cell secretory granules are endogenous c-type lectin receptor ligands skewing dendritic cell function towards Th2/Th17 response Johanna Kotrba, Bernd Lepenies, Anne Dudeck, Germany CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection Alaz Ozcan, Victor Collado Diaz, Cecilie Egholm, Michio Tomura, Cornelia Halin, Antonios Georgios Alexandros Kolios, Onur Boyman, Switzerland Peripheral mast cell-derived RANKL is a prerequisite for lymphocyte egress from distant lymph nodes Konstantinos Katsoulis Dimitriou, Waqar Umer, Melanie Haffner Luntzer, Hanna Edler, Kathleen Baumgart, Burkhart Schraven, Julia Fröbel, Annita Ignatius, Jan Dudeck, Anne Dudeck, Germany Enrichment of bioorthogonal antigens from dendritic cells to study antigen processing on peptide level Tyrza Van Leeuwen, Can Araman, Linda Pieper Pournara, Thomas Bakkum, Mirjam Groenewold, Ward Doelman, Bogdan Florea, Sander Van Kasteren, Herman Overkleeft,The Netherlands Autoantibodies isolated from Systemic Sclerosis patients targeting the angiotensin II type 1 and endothelin-1 type A receptor induce endothelial cell activation and pro-fibrotic cellular responses Cynthia M. Fehres, Bryan Koolmoes, Nivine W.N. Levarth, Huub J. Sijben, Laura H. Heitman, Rudmer J. Postma, Vincent Van Duinen, Anton Jan Van Zonneveld, Gabriela Riemekasten, Rene E.M. Toes, Jeska K. De Vries Bouwstra, The Netherlands

Workshop - TRACK 3 WS.T3.06 - Immune Deficiencies 16:00 – 17:15 | HALL 10 Chairs: Arpad LANYI, Hungary & Elif KARAKOC AYDINER, Turkey The imbalance of the circulating regulatory B cell subsets in patients with primary immunodeficiencies Sevil Oskay Halaçlı, Dilan Inan, Hacer Neslihan Bildik, Ayşegül Akarsu, Melike Kahveci, Begüm Özbek, Ismail Yaz, Çagman Tan, Saliha Esenboğa, Deniz Çağdaş Ayvaz, Ilhan Tezcan, Turkey

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Novel heterozygous missense mutations in NFkB1 causes immunedysregulation and immunodeficiency Manfred Anim, Natalia Dubrowinskaja, Georgios Sogkas, Ryan Ignatius Adriawan, Torsten Witte, Reinhold Ernst Schmidt, Faranz Atschekzei, Germany Warm autoimmune hemolytic anemia is associated with a regulatory T cell deficiency and a Th17 polarization Marion Ciudad, Sethi Ouandji, Claudie Cladiere, Thibault Ghesquiere, Marine Thebault, François Maurier, Thibault Maillet, Maxime Samson, Philippe Saas, Bernard Bonnotte, Sylvain Audia, France The role of DYRK1A in B cell immune responses Liat Stoler Barak, Amalie Grenov, Hadas Hezroni Bravyi, Ayelet Peres, Gur Yaari, Ziv Shulman, Israel COVID-19 in patients with primary and secondary immunodeficiencies: A single-center experience Meryem Demir, Gulhan Bogatekin, Ceyda Tunakan Dalgic, Sinem Inan, Omur Ardeniz, Turkey Second tier testing to reduce the number of non-actionable secondary findings and false positive referrals in newborn screening for severe combined immunodeficiency Maartje Blom, Ingrid Pico Knijnenburg, Sandra Imholz, Lotte Vissers, Janika Schulze, Jeannette Werner, Robbert Bredius, Mirjam Van Der Burg, The Netherlands CHAPLE disease and non-CHAPLE protein losing enteropathies: natural history and immune characteristics Merve Selcuk, Asena Pinar Sefer, Dilek Baser, Ismail Ogulur, Sevgi Bilgic Eltan, Esra Dursun, Burcu Kocamis, Nurhan Kasap, Safa Baris, Elif Karakoc Aydiner, Ahmet Oguzhan Ozen, Turkey

KL.3 Environmental Influences on Intestinal Immune 19:00 – 20:00 | HALL 1 Responses and Epithelial Cell Homeostasis Brigitta STOCKINGER, United Kingdom Chairs: Mark COLES, United Kingdom & Faith OSIER, United Kingdom

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Thursday, September 2, 2021

PL.1 Human T Cells in Health and Disease 09:30 – 10:15 | HALL 1 Federica SALLUSTO, Switzerland Chairs: Silke APPEL, Norway & Pablo ENGEL, Spain PL.2 Single Cell Omics and a Pandemic: 10:30 – 11:15 | HALL 1 Did We Learn Something that Helps Us for Other Diseases As Well? Joachim SCHULTZE, Germany Chairs: Luca VANNUCCI, Czech Republic & Sarah TEICHMANN, United Kingdom S1.3 – NK Cell Biology from Basic Science to Clinical Therapy 11:30 – 12:45 | HALL 1 Chairs: Eric VIVIER, France & Ofer MANDELBOIM, Israel Inside the Mind of a Killer Novel Insights into the Cytotoxic Mechanisms of Natural Killer Cells Carsten WATZL, Germany Suppressing the Suppressors-Intracellular Inhibitory Checkpoint Pathways as Targets for Next- Generation NK-Cell Based Therapies Mira BARDA-SAAD, Israel Harnessing Innate Immunity for Patients: From Cancer to COVID-19 Eric VIVIER, France

MS2.2 – Cell Death in Immunology 11:30 – 13:00 | HALL 2 Chairs: Anita MILICIC, United Kingdom & Arturo ZYCHLINSKY, Germany Immunogenic Cell Death: Endogenous and Exogenous Adjuvant Signals Guido KROEMER, France Elevated Type I IFN Levels Trigger NETosis in DNA Repair Deficiencies Mayda GURSEL, Turkey Extracellular Function in Immunity Arturo ZYCHLINSKY, Germany

MS3.2 – Innate Immune Response 11:30 – 13:00 | HALL 3 Chairs: Mihai NETEA, The Netherlands & Sergei NEDOSPASOV,Russia Regnase-1 as a Regulator of Metabolism and Immune Responses Akira SHIZUO, Japan Connecting Myeloid Cell Metabolism and Function David SANCHO, Spain Trained Immunity: a Memory for Innate Host Defense Mihai NETEA, The Netherlands MS4.2 – Dendritic Cells in Immune Response 11:30 – 13:00 | HALL 4 Chairs: Francesca GRANUCCI, Italy & Andrey TCHORBANOV, Bulgaria Dendritic Cells in COVID-19 and other Inflammatory Conditions Francesca GRANUCCI, Italy DC Targeted Nanovaccines for the Induction of Immunity or Tolerance Yvette VAN KOOYK, The Netherlands IL-10-Related Regulatory Cell Biology and Applications to Control Unwanted Immune Responses Silvia GREGORI, Italy

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Expert’s Guide to Publishing 11:30 – 13:00 | HALL 5 Moderator: Nadja BAKOCEVIC, Germany Preparing Your Manuscript Petter HÖGLUND, Sweden Peer Review – Tips from an Editor James DI SANTO, France Understanding Research Ethics and Integrity in Academia Sucharita KUNDU, United Kingdom

Bright Spark - TRACK 1 BS.T1.01 – Cellular Immunology 11:30 – 12:45 | HALL 6 Chairs: Tamara SAKSIDA, Serbia & Trever OWENS, Denmark The glycolysis intermediate lactate is essential for the suppressive function of human thymus-derived regulatory T cells Sander De Kivit, Mark Mensink, Esther Zaal, Ellen Schrama, Celia Berkers, Jannie Borst, The Netherlands The ability of extracellular vesicle-coating antibody light chains to bind antigenic peptides determines their immune suppressive activity Katarzyna Nazimek, Philip W. Askenase, Krzysztof Bryniarski , Poland A type 3 immunity (RORγt+) intrinsic PPARγ regulation contributes to diet-induced obesity Maroua Ferhat, Lauralie Christophe, Laura Boulange, Jean Yves Jouzeau, Gérard Eberl, David Moulin, France Maintenance of longlived memory plasma cells by contact to stromal cells through activation of PI3K/ AKT and inactivation of FoxO1/3 prevents activation of caspase 3 Rebecca Cornelis, Stefanie Hahne, Hyun Dong Chang, Andreas Radbruch, Germany Characterisation of neonatal innate lymphoid subsets reveals a novel precursor able to generate NKG2A-KIR+ NK cells Sabrina Bianca Bennstein, Sandra Weinhold, Nadine Scherenschlich, Katharina Raba, Gesine Kögler, Lutz Walter, Markus Uhrberg, Germany Phenotypic and spatial characteristics of human innate lymphoid cells revealed by highly multiplexed histology Anna Pascual Reguant, Ralf Köhler, Ronja Mothes, Sandy Bauherr, Daniela Hernández, Ralf Uecker, Karolin Holzwarth, Katja Kotsch, Maximilian Seidl, Lars Philipsen, Werner Müller, Chiara Romagnani, Raluca Niesner, Anja Hauser, Germany

Workshop - TRACK 2 WS.T2.03 - Immune Response Regulation: Metabolism 11:30 – 12:45 | HALL 7 Chairs: Sarah DIMELOE, United Kingdom & Thomas WEICHHART, Austuria The autophagy core protein ATG5 is essential to maintain intestinal RORgt+ Foxp3+ Treg cells Carlos Plaza Sirvent, Bei Zhao, Alisha Bronietzki, Marina Pils, Neda Tafrishi, Marc Schuster, Till Strowig, Ingo Schmitz, Germany Effect of glucose-transporter inhibitors on the function of Natural Killer cells Lea Katharina Boller, Slava Ziegler, Herbert Waldmann, Carsten Watzl, Germany Alveolar lipids regulate the response of alveolar macrophages to IL-4 Belen Garcia Fojeda, Carlos Montero, Carlos Minutti, Marianela Landoni, Cristina Casals, Spain

6th European Congress of Immunology, September 1-4, 2021 47 Thursday, September 2, 2021

Mitochondrial arginase-2 is essential for IL-10 mediated metabolic reprogramming of inflammatory macrophages Remsha Afzal, Jennifer K Dowling, Linden J Gearing, Mariana P Cervantes Silva, Gavin M Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel Gough, Christoph Hess, Paul J Hertzog, Claire E Mccoy, Ireland Circadian disruption increases the inflammatory response of lung fibroblasts Shannon L Cox, Richard G Carroll, Annie M Curtis, Ireland Pectic polysaccharide RG-I from bell pepper and carrot stimulates protective innate immune responses and modulates gut microbiota in humans Sue Mckay, Paul Oranje, Jari Helin, Jean Koek, Ellen Kreijveld, Pieter Van Den Abbeele, Ute Pohl, Gordana Bothe, Maria Tzoumaki, Marcela Aparicio Vergara, Annick Mercenier, Henk Schols, Ruud Albers, The Netherlands The autophagy receptor TAX1BP1 (T6BP) is a novel player in viral antigen presentation by MHC-II molecules Mathias Pereira, Clémence Richetta, Gabriela Sarango, Anita Kumari, Michael Ghosh, Lisa Bertrand, Cédric Pionneau, Morgane Le Gall, Sylvie Grégoire, Raphaël Jeger Madiot, Elina Rosoy, Mathias Faure, Audrey Esclatine, Stéphanie Graff Dubois, Stefan Stefanović, Bénédicte Manoury, Bertha Cecilia Ramirez, Arnaud Moris, France

Workshop - TRACK 1 WS.T1.01 - B Lymhocyte Regulation & Function 11:30 – 12:45 | HALL 8 Chairs: Katharina PRACHT, Germany & Ali Onder YILDIRIM, Germany Tissue-resident B cells orchestrate macrophage phenotype and function in non-lymphoid organs Ondrej Suchanek, John R Ferdinand, Sathi Wijeyesinghe, Zewen K Tuong, Simon Clare, Rachael Bashford Rogers, Anita Chandra, Krishnaa Mahbubani, Trevor Lawley, Klaus Okkenhaug, David Masopust, Menna R Clatworthy, United Kingdom Novel players in B cell antigen uptake and trafficking Dessi Malinova, United Kingdom Most isotype-switched memory B cells reside in bone marrow or spleen Marta Ferreira Gomes, René Riedel, Richard Addo, Frederik Heinrich, Gitta Anne Heinz, Jannis Kummer, Victor Greiff, Daniel Schulz, Cora Klaeden, Rebecca Cornelis, Gabriela Maria Guerra, Anja E. Hauser, Sai T. Reddy, Pawel Durek, Hyun Dong Chang, Mir Farzin Mashreghi, Andreas Radbruch, Germany Evolution of the SARS-CoV-2 specific B cell and antibody repertoires over time Nieke van der Bolt, Maria Chernigovskaya, Mathieu Claireaux, Remco Visser, Floris van Alphen, Mirjam van der Burg, Anja ten Brinke, Victor Greiff, Marit Gils, Ellen van der Schoot, The Netherlands IL-21 is a key regulator of chronic germinal centre responses in CTLA-4-deficient mice Lina Petersone, Natalie Mona Edner, Ellen Margaret Ross, Elisavet Ntavli, Yassin Awadalla Omer Mohamed Elfaki, Chunjing Wang, Lucy Sarah Kate Walker, United Kingdom Termination of CD40L signaling drives human naïve B cell differentiation into antibody-secreting cell formation Casper Marsman, Niels J.M. Verstegen, Marij Streutker, Anja Ten Brinke, Marieke Van Ham, The Netherlands The RNA-binding protein HuR is essential for maintenance of the germinal centre response Ines C. Osma Garcia, Dunja Capitan Sobrino, Mailys Mouysset, Sarah E. Bell, Manuel Lebeurrier, Martin Turner, Manuel D. Diaz Muñoz, France

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Workshop - TRACK 4 WS.T4.06 - Innovative Technologies and Immunotherapies 11:30 – 12:45 | HALL 9 Chair: Vera MARTINS, Portugal & Duygu SAG, Turkey Proteomic analysis of exosomes highlights their role in specific-signaling pathways’ modulation during Leishmania infection in macrophage Antonia Efstathiou, Dimitra K. Toubanaki, Martina Samiotaki, George Stamatakis, Evdokia Karagouni, Greece Drafting an evidence-based immune-related adverse outcome pathway of interleukin-2-induced adverse effects on human lung tissue Charline Sommer, Susann Dehmel, Vanessa Neuhaus, Christopher Werlein, Eike Preuss, Patrick Zardo, Danny Jonigk, Katherina Sewald, Armin Braun, Germany A lateral flow assay to detect neutralising antibodies against SARS-CoV-2 Thomas S Fulford, Huy Van, Nicholas A Gherardin, Shuning Zheng, Marcin Ciula, Heidi E Drummer, Samuel Redmond, Hyon-Xhi Tan, Rob J Center, Fan Li, Samantha Grimley, Bruce D Wines, Mark Hogarth, Zoe McQuilten, Kanta Subbarao, Katherine Kedzierska, Jennifer J Juno, Adam K Wheatley, Stephen J Kent, Deborah A Williamson, Damian FJ Purcell, David A Anderson, Dale I Godfrey, Australia Avidin-based Universal CAR regulatory T cells (UniCAR-Tregs): a versatile approach for future immunotherapy Jorge Gallego-Valle, Sergio Gil-Manso, Ana Pita, Esther Bernaldo-de-Quiros, Verónica Astrid Pérez Fernandez, Rocío López-Esteban, Ramón Pérez-Caballero, Carlos Pardo, Juan Miguel Gil-Jaurena, Rafael Correa-Rocha, Marjorie Pion, Spain A supported lipid bilayer platform to study the impact of bi-specific engager architecture on T cell activation Alexander Leithner, Srinath Kasturirangan, Michael L Dustin, United Kingdom Pembrolizumab drug levels and anti-drug antibodies: measurement in two real-world centres Laura Wilkins, Sarah Sasson, Anna Olsson Brown, Carol Jolly, Robert Watson, Paul Klenerman, Oliver Brain, Benjamin Fairfax, United Kingdom Single-cell metabolic profiling of macrophage polarization by fluorescence lifetime imaging microscopy (FLIM) Nuno GB Neto, Sinead O’Rourke, Mimi Zhang, Aisling Dunne, Michael G. Monaghan, Ireland

Workshop - TRACK 3 WS.T3.08 - Maintenance and Local Regulation of Tissue 11:30 – 12:45 | HALL 10 Specific Immunity Chairs: Maxim NOSENKO, Russia & Nese AKIS, Turkey Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH Michael Dudek, Percy Knolle, Sainitin Donakonda, Mathias Heikenwälder, Dominik Pfister, Pamela Filpe, Marcial Sebode, Frank Tacke, Adrien Guillot, Felix Bayerl, Philippa Meiser, Martina Anton, Susanne Roth, Melanie Laschinger, Norbert Hüser, Daniel Hartmann, Andrew Bowman, Ron Heeren, Simon Reider, Herbert Tilg, Tobias Boettler, Edward Pearce, Jan Francois Dufour, Germany The critical expansion of uterine CD8+ T cells in pregnancy is under tight homeostatic control Lilja Hardardottir, Maria Victoria Bazzano, Eva Tolosa, Petra Clara Arck, Hans Willi Mittrücker, Maria Emilia Solano, Germany

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Single cell sequencing reveals expanded cytotoxic CD4+ T cells and two states of peripheral helper T cells in synovial fluid of ACPA+ Rheumatoid Arthritis patients Alexandra Argyriou, Marc H. Wadsworth Ii, Adrian Lendvai, Stephen M. Christensen, Aase H. Hensvold, Christina Gerstner, Kellie Kravarik, Aaron Winkler, Vivianne Malmström, Karine Chemin, Sweden Innate PD-L1 limits T cell mediated adipose tissue inflammation Christian Schwartz, Andrea Deinzer, Heike C Hawerkamp, Emily Hams, Viviane Schmidt, Jasmin Bayerlein, Ole Röger, Moritz Bailer, Christian Krautz, Moustafa El Shafei, Andrew E Hogan, Donal O’shea, Padraic G Fallon, Germany Stimulation of the PD-1 pathway decreases atherosclerotic lesion development in Ldlr deficient mice Hendrika W Grievink, Robin A.f. Verwilligen, Virginia Smit, Mireia N.a. Bernabé Kleijn, Diede N. Smeets, Christoph J. Binder, Hideo Yagita, Matthijs Moerland, Johan Kuiper, Ilze Bot, Amanda C. Foks, The Netherlands Increased inflammatory parameters, chemokines and chemokine receptors in obese children Anita Spehar Uroic, Masa Filipovic, Nevena Krnic, Alan Sucur, Danka Grcevic, Croatia Human intrahepatic CD56bright NK cells display a tissue-resident transcriptional profile and enhanced ability to kill allogenic CD8+ T cells Gráinne Jameson, Cathal Harmon, Rhyla Mae Santiago, Tom Gallagher, Lydia Lynch, Mark W. Robinson, Cliona O’Farrelly, Ireland

Interactive Sessions Discussion Lounge: Vacccine Inequity 14:30 – 15:30 | ROOM 1 Speaker: Mayda GURSEL COVID-19 vaccinations started on December 2020. Since then, as of 14 July 2021, 25.4% of theworld population has received at least one dose of a COVID-19 vaccine. However, so far, only 1% of people in low- income countries have received at least one dose, demonstrating the current state of vaccine inequity. This discussion lounge will try to come up with suggestions to tackle vaccine inequity in the context of COVID-19 and possible future pandemics through a brainstorming session with interested participants.

EJI - yEFIS Lounge Session: How to Succeed in Academia 14:30 – 15:30 | ROOM 3 In this session, established European immunologists, who are also active editors of the European Journal of Immunology (EJI) will answer questions asked by young immunologists, share their career path and provide key tips on academic success. Join us for a panel discussion moderated by yEFIS members and learn about career in academia, grant applications and much more. Questions from the audience are encouraged and you will have an opportunity to directly speak to our panellists: Muzlifah HANIFFA, United Kingdom Chiara ROMAGNANI, Germany Emma SLACK, Switzerland Bart EVERT, The Netherlands

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BSI Interactive Session for ECRs 14:30 – 15:30 | ROOM 4 How to accelerate your career through engaging with journals – a British Society for Immunology session for ECRs This panel discussion will examine what scientific journals can do to support the career development of Early Career Researchers (ECRs). We will cover how ECRs can get involved in the editorial and peer review process of a scientific journal and how journals and Editors can engage with ECRs, helping them to build their skills, encouraging them to contribute as journal ambassadors and reviewers while supporting them through the process and ensuring they are recognised for their contribution. Chair: Ann AGER, United Kingdom Panelists: Tim ELLIOTT, United Kingdom Marianne BOES, The Netherlands Elizabeth MANN, United Kingdom Alysya AFFANDI, The Netherlands President’s Symposium 15:30 – 17:00 | HALL 1 Chair: Andreas RADBRUCH, Germany mRNA Vaccines and Beyond Ugur SAHIN, Turkey COVID-19 Immunology and Aging of the Immune System Andrea COSSARIZZA, Italy Human Immune System Mark DAVIS, USA

MS1.2 – Regulation of Adaptive Immune Responses 17:15 – 18:45 | HALL 1 Chairs: Ahmet GUL,Turkey & Asimina FYLAKTOU, Greece Microbiota-Derived Metabolite in the Amelioration Arthritis: Novel Role of Serotonin Metabolites in B Cells Differentiation Claudia MAURI, United Kingdom Dendritic Cell Crosstalk in CD4 T Cell Help for the Cytotoxic T Cell Response Jannie BORST, The Netherlands A Novel and Human-Specific Role for the Complosome in the Regulation of Chromatin Landscapes Claudia KEMPER, USA

S2.2 – Innate to Adaptive 17:15 – 18:30 | HALL 2 Chairs: Paloma Sanchez MATEOS, Spain & Winfried PICKL, Austria Why We Get Sick; Interactions Between the Immune and Endocrine Systems during Viral Infection Felix WENSVEEN, Croatia Antigen-Specificity in Human Immunopathologies Alexander SCHEFFOLD, Germany Loss of Innate and Adaptive Immune Regulation in Inflammatory Bowel Disease Janneke SAMSOM, The Netherlands

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S3.5 – COVID-19 Vaccine Development 17:15 – 18:30 | HALL 3 Chairs: Adrian HAYDAY, United Kingdom & Mayda GURSEL, Turkey Cell-mediated and Humoral Adaptive Immune Responses to Sars-CoV-2 S Protein in COVID-19 Patients and Vaccinated Subjects Francesco ANNUNZIATO, Italy Story of the Development of Oxford Adenovirus Vector Based Vaccine Against COVID-19 Pandemic Teresa LAMBE, United Kingdom Antibody Responses to SARS-CoV-2 Spike After Infection And Vaccination Florian KRAMMER, USA

S4.2 – Cancer Immunotherapy 17:15 – 18:30 | HALL 4 Chairs: Suhendan EKMEKCIOGLU, USA & Tanja de GRUJIL, The Netherlands Antigen-Specific Retargeting of Natural Killer Cells for Cancer Immunotherapy Tolga SUTLU, Turkey Novel Immune Checkpoint Receptors in Cancer Therapy Linde MEYAARD, The Netherlands Local Interventions with Global Impact: Targeting Tumor-Draining Lymph Nodes Tanja de GRUIJL, The Netherlands

ACTERIA & EFIS AWARDS SESSION 17:15 – 18:45 | HALL 5 Chairs: Andreas RADBRUCH, Germany & Anne HOSMALIN, France

2021 EFIS-EJI Ita Askonas Prize Laureate Tryptophan-Degrading Enzymes Represent Metabolic Immune Checkpoints That Activate The Aryl Hydrocarbon Receptor Christiane OPITZ, Germany

2021 ACTERIA Early Career Research Prize Laureate in Immunology Hepatic Macrophage Heterogeneity, Who, Why and Where? Charlotte SCOTT, Belgium

2021 ACTERIA Early Career Research Prize Laureate in Allergology Bidirectional Peripheral Neuron-Immune Interactions: A New Vision in The Understanding of Tissue Homeostasis Nicolas GUADENZIO, France

Best Poster Session - Track 2 BP.T2.01 - Molecular Immunology 17:15 – 18:30 | HALL 6 Chairs: Martina COLICCHIA, United Kingdom & Batu ERMAN, Turkey The Jury will make their nominations for the Best Poster session after pre-viewing of posters in the E-poster Hall. Therefore, the line up of Best Poster presenters will not be available until August 31st. You may view the line-up on the congress web platform once it is announced.

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Workshop - TRACK 4 WS.T4.04 - Therapy in Autoimmunity and Allergies 17:15 – 18:30 | HALL 7 Chairs: Jon LAMAN, The Netherlands & Defne BAYIK, USA Protective long-term effects of mesenchymal stromal/stem cell-based therapy in experimental colitis is mediated by induction of an innate immune memory-like response Mercedes Lopez Santalla, Rosario Hervas Salcedo, Maria Fernandez Garcia, Juan Antonio Bueren, Marina Inmaculada Garin, Spain MOG-derived Imotope™, inducing cytolytic CD4+ T cells and reducing EAE manifestations in mice, as novel antigen-specific immunotherapy for multiple sclerosis Isabelle Ote, David Walgraffe, Roxana Roohi Ahangarani, Milos Erak, Marcelle Van Mechelen, Luc Vander Elst, Vincent Carlier, Antoon Van Oosterhout, Belgium Functionalization of tolerogenic dendritic cells with iron oxide magnetic nanoparticles for their magnetic retention Andres Paris, Domingo F. Barber, Spain Immunotherapy with apitopes® blocks the immune response to S-antigen in HLA-DR transgenic mice Evelien Schurgers, Brecht Hoedemaekers, David C. Wraith, Lotta Jansson, Belgium Aromatic ketoacids represent novel therapies for inflammatory diseases through activation of the Nrf2/HO-1 pathway and suppression of pro-inflammatory responses in primary human immune cells Hannah K Fitzgerald, David G Williams, Nicole K Campbell, Paul J Barry, Sinead A O’Rourke, Nuno G Neto, Michael G Monaghan, Derek P Nolan, Aisling Dunne, Ireland Immune reconstitution after autologous hematopoietic stem cell transplantation in multiple sclerosis Josefine Ruder, Simon Obahor, Jordan Rex, Antonia Müller, Ilijas Jelcic, Roland Martin, Switzerland Selective elimination of allergen-specific B lymphocytes in chronic mouse house dust mite allergy model Nikola Ralchev, Nikolina Mihaylova, Nikola Kerekov, Andrey Tchorbanov, Bulgaria

Workshop - TRACK 3 WS.T3.13 – Neuroinflammation 17:15 – 18:30 | HALL 8 Chairs: Ahmet EKEN, Turkey & Eva MARTINEZ CACERES, Spain Eomes controls central nervous system inflammation by increasing survival of effector CD4 T cells through the regulation of mitochondrial metabolism Emeline Joulia, Michaël F Michieletto, Arantxa Agesta, Cindy Peillex, Anne Louise Le Dorze, Virginie Girault, Manuel Lebeurrier, Thierry Walzer, Jean Emmanuel Sarry, Marion Szelechowski, Anne S Dejean, France Towards the suppression of the disease-relevant brain-homing CD4+ T cell in multiple sclerosis Steven Koetzier, Jamie Van Langelaar, Katelijn Blok, Annet Wierenga Wolf, Marie José Melief, Thierry Van Den Bosch, Willem Dik, Georges Verjans, Helga De Vries, Rinze Neuteboom, Joost Smolders, Marvin Van Luijn, The Netherlands Defining the role of microglia in Relapsing-Remitting EAE Zhana Haimon, Louise Chappel Maor, Steffen Jung, Israel Oncostatin M opens the gate for T helper 17 cells during neuroinflammation Doryssa Hermans, Evelien Houben, Paulien Baeten, Baharak Hosseinkhani, Seppe Bormans, Ronald Thoelen, Elga De Vries, Niels Hellings, Bieke Broux, Belgium

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Kinin-B2 receptor signaling in neuroinflammation and innate immune response in Alzheimer’s disease Henning Ulrich, Fernanda Tibolla Viero, Micheli Mainardi Pillat , Brazil Fas/FasL contributes to HSV-1 brain infection and neuroinflammation Malgorzata Krzyzowska, Karolina Thorn, Kristina Eriksson, Sweden Circulating immune profile changes reflect memory immune responses in spinal cord injury patients Judith Fraussen, Lien Beckers, Charlotte C. Van Laake Geelen, Bart Depreitere, Jens Deckers, Dieter Peuskens, Veerle Somers, Belgium

Workshop - TRACK 1 WS.T1.07 - T Lymphocyte Function 17:15 – 18:30 | HALL 9 Chairs: Adil Doğanay DURU, The Netherlands & Michael BERGER, Israel CD8+ T cells require signal 3 from non-antigen-presenting cells for optimal clonal expansion Jun Abe, Philipp Germann, Jorge Ripoll, James Sharpe, Jens V Stein, Switzerland IL-10 engineered Dendritic cells modulate allogeneic cytotoxic CD8+ T cells response in vitro Marta Fortunato, Giada Amodio, Silvia Gregori, Italy Targeting the microtubule-network to improve CTL killing capacity in dense 3D matrices Renping Zhao, Xiangda Zhou, Essak S. Khan, Dalia Alansary, Kim S. Friedmann, Wenjuan Yang, Eva C. Schwarz, Aránzazu Del Campo, Markus Hoth, Bin Qu, Germany Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest Amijai Saragovi, Ifat Abramovich, Ibrahim Omar, Eliran Arbib, Ori Toker, Eyal Gottlieb, Michael Berger, Israel Copper homeostasis is required for T cell activation Alexandra H Mandarano, Maureen A McGargill, United States Extrinsic factors govern human MAIT cell transcriptional and functional plasticity Lucy C. Garner, Nicholas M. Provine, Paul Klenerman, United Kingdom Normality-Sensing Licenses Local T cells for Innate-like Tissue-surveillance Duncan R Mckenzie, Rosie Hart, Nourdine Bah, Dmitry S Ushakov, Regina Feederle, Adrian C Hayday, United Kingdom

Workshop - TRACK 3 WS.T3.09 - Microbial, Fungal, and Parasitic Immunology 17:15 - 18:30 | HALL 10 Chairs: Hanna JARVA, Finland & Ricardo SILVESTRA, Portugal Role of danger and microbial signals in the control of the recruitment of neutrophil subpopulations during infections Giulia Stucchi, Laura Marongiu, Irene Artuso, Alessandra Maria Martorana, Francesca Mingozzi, Ivan Orlandi, Marina Vai, Alessandra Polissi, Ivan Zanoni, Francesca Granucci, Italy Liver resident CD4 T cells in malaria infection Matthias H Enders, Lynette Beattie, Anton Cozsijnsen, Irina Caminschi, Geoffreey I Mc Fadden, Elvira Mass, Daniel Ferndandez Ruiz, William R Heath, Australia Macrophage innate training induced by IL-4 activation enhances OXPHOS driven anti-mycobacterial responses Mimmi L E Lundahl, Morgane Mitermite, Dylan G Ryan, Niamh C Williams, Ming Yang, Filipa Lebre, Aoife L Gorman, Bojan Stojkovic, Christian Frezza, Eoin M Scanlan, Luke A J O’neill, Stephen V Gordon, Ed C Lavelle, Ireland 6th European Congress of Immunology, September 1-4, 2021 54 Thursday, September 2, 2021

Trained immunity confers prolonged protection against systemic listeriosis Charlotte Théroude, Rémi Porte, Barbara Bottazzi, Irene T. Schrijver, Eleonora Ciarlo, Didier Leroy, Marta Reverté Royo, Thierry Calandra, Cecilia Garlanda, Thierry Roger, Switzerland Sepsis induces long-term reprogramming of human hematopoietic stem cells Marco De Zuani, Marcela Hortová Kohoutková, Ivana Andrejčinová, Veronika Bosaková, Veronika Tomašková, Vladimír Šrámek, Martin Helán, Jan Frič, Czech Republic Afucosylated IgG is naturally produced in response to intracellular pathogens including SARS-CoV-2 and Plasmodium falciparum but not by subunit vaccination Mads Delbo Larsen, Mary Lopez-Perez, Emmanuel Kakra Dickson, Paulina Ampomah, Nicaise Tuikue Ndam, Jan Nouta, Carolien A M Koeleman, Agnes L Hipgrave Ederveen, Benjamin Mordmüller, Ali Salanti, Morten Agertoug Nielsen, Achille Massougbodji, C. Ellen van Der Schoot, Michael F. Ofori, Manfred Wuhrer, Lars Hviid, Gestur Vidarsson, Netherlands The alternative pathway of complement and long pentraxin PTX3 form a functional axis in the immune response to Aspergillus fumigatus Raffaella Parente, Valentina Possetti, Francesca Petroni, Matteo Stravalaci, Marina Sironi, Sonia Valentino, Anthony J Day, Barbara Bottazzi, Agostinho Carvalho, Alberto Mantovani, Antonio Inforzato, Italy

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Friday, September 3, 2021

S1.4 – Regulatory T Cells in Health and Disease 09:30 - 10:45 | HALL 1 Chairs: Jelena BEZBRADICA MIRKOVIC, United Kingdom & Markus FEUERER, Germany Regulatory T Cells in Nonlymphoid Tissues in Man and Mouse Markus FEUERER, Germany Metabolic Control of Treg Expansion in Cancer Silvia PICONESE, Italy Targets of the Immune System in the IPEX Syndrome Nils LANDEGREN, Sweden

S2.3 – Challenges in Vaccinology 09:30 - 10:45 | HALL 2 Chairs: Africa González FERNANDEZ, Spain & Ursula WIEDERMANN SCHMIDT, Austria Innate and Adaptive B Cell Memory: Pros and Cons of Specialization Rita CARSETTI, Italy Novel Vaccine Adjuvant Strategies to Promote Cell Mediated Immunity Ed LAVELLE, Ireland Self-Amplifying RNA Technology; Precision Vaccines for this Pandemic and the Next Katrina POLLOCK, United Kingdom

S3.3 – Immunotherapy in Transplantation 09:30 - 10:45 | HALL 3 Chairs: Marcos LOPEZ HOYOS, Spain & Chiara ROMAGNANI, Germany Targeting Trained Immunity in Transplantation and Cancer Jordi OCHANDO, Spain The Future of Treg Therapy: From Polyclonal to Genetically Modified Tregs Giovanna LOMBARDI, United Kingdom Immunotherapy and Chimerism on Organ Transplantation Christine FALK, Germany

S4.3 – Emerging Tools in Immune Response 09:30 - 10:45 | HALL 4 Chairs: Arzu L. ARAL, Turkey & Katerina TARASSI, Greece Integrated Approaches to Decipher the TCR Signaling Network Romain RONCAGALLI, France Quantitative Tools to Investigate the Interaction of Colloidal Nanoparticles with Biology Wolfgang PARAK, Germany Analyzing the Antibody Response with Machine Learning Algorithms Ioannis THEODOROU, France

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BRIGHT SPARKS WORKSHOP - TRACK 2 BS.T2.01 - Moleculer Immunology 09:30 – 10:45 | HALL 5 Chairs: Mayda GURSEL, Turkey & Zoltan PROHASZKA, Hungary Effect of microRNA gga-let-7f on chicken macrophage functions in the context of antiviral responses Kelsey O’Dowd, Neda Barjesteh, Carl A Gagnon, Canada Distinct transcription factor networks control neutrophil-driven inflammation Zhichao Ai, Tariq Khoyratty, Ivan Ballesteros, Hayley Eames, Sara Mathie, Sandra Martín Salamanca, Lihui Wang, Erinke Van Grinsven, Andres Hidalgo, Irina Udalova, United Kingdom Protection against severe lower respiratory infections in infants by Innate Immune Training: mechanism-of-action studies Niamh M Troy, Sally Galbraith, Zahir Islam, Michael Serralha, Barbara Holt, Deborah Strickland, Peter Sly,Anthony Bosco, Patrick Holt, Australia Inhibition of drug-induced liver injury in mice using a positively-charged peptide that binds DNA Sofie Vandendriessche, Pedro Elias Marques, Thiago H.c. De Oliveira, Helena Crijns, Marfa Blanter, Sara Schuermans, Karen Yu, Paul Proost, Belgium SARS-CoV-2-induced immunity depends on cytosolic sensors Lieve E.H. van der Donk, Julia Eder, Marta Bermejo-Jambrina, Teunis B.H. Geijtenbeek, Netherlands The role of glucose transporter type 1 in plasma cells Theresa Bierling, Amelie Gumann, Karin Van Schie, Magdalena Wichert, Manuela Hauke, Jens Wittner, Wolfgang Schuh, René E. M. Toes, Hans Martin Jäck, Katharina Pracht , Germany

Best Poster Session - Track 3 BP.T3.01 - Diseases and Immune Responses 09:30 – 10:45 | HALL 6 Chairs: Vedat BULUT, Turkey & Matja RIJAVEC, Slovenia The Jury will make their nominations for the Best Poster session after pre-viewing of posters in the E-poster Hall. Therefore, the line up of Best Poster presenters will not be available until August 31st. You may view the line-up on the congress web platform once it is announced.

Workshop - TRACK 1 WS.T1.02 T Cell Development 09:30 – 10:45 | HALL 7 Chairs: Michael LOHOFF, Germany & Wilfried ELLMEIER, Austria An integrated multi-omics view on human T cell development Juliette Roels, Matthias De Decker, Enrico Gaffo, Govardhan Anande, Palaniraja Thandapani, Lena Böhme, Jolien Van Hulle, Anaïs Derveeuw, Imke Velghe, Yana Van Droogenbroeck, Tom Putteman, Alessia Buratin, Nandan Deshpande, Ashwin Unnikrishnan, Stefania Bortoluzzi, Iannis Aifantis, Pieter Van Vlierberghe, Tom Taghon, Belgium Single-cell transcriptomics reveals discrete steps in regulatory T cell development in the human thymus Florencia Morgana, Rianne Opstelten, Manon C Slot, Andrew M Scott, Bianca Blom, Ahmed Mahfouz, Derk Amsen, The Netherlands The rules of engagement of dendritic cells in thymic cooperative antigen transfer Jiří Březina, Matouš Vobořil, Dominik Filipp, Czech Republic

6th European Congress of Immunology, September 1-4, 2021 57 Friday, September 3, 2021

Functional characterisation and transcriptomic analysis of antigen-specific CD8 T memory stem cells (TSCM) generated from clonally expanded single TSCM cells in vitro Yanran Zhao, Elizabeth Keoshkerian, Hui Li, Hongyan An, Rowena A. Bull, Fabio Luciani, Andrew R. Lloyd, Australia Unique cellular sources of CXCR3 ligands direct intranodal T cell positioning and effector/stem-like memory fates following viral infection Fanny Lafouresse, Brigette C Duckworth, Verena C Wimmer, Benjamin J Brommfield, Lennard Dalit, Yannick 0 Alexandre, Amania A Sheikh, Raymond Z Qin, Carolina Alvarado, Lisa A Mielke, Marc Pellegrini, Scott N Mueller, Thomas Boudier, Kelly L Rogers, Joanna R Groom, France Relevance of Th17-specific epigenetic signature genes for Th17 differentiation and function Nesrine Marzougui Ep Essalah, Beate Pietzsch, Jana Niemz, Susanne Strahlendorff Herppich, Agnes Bonifacius, Stefan Floess, Jochen Huehn, Germany Developmental bifurcation of human T follicular regulatory cells Saumya Kumar, Valter R Fonseca, Filipa Ribeiro, Afonso Basto, Ana Agua Doce, Marta Monteiro, Dikelele Elessa, Ricardo J Miragaia, Tomas Gomes, Eliane Piaggio, Elodie Segura, Margarida Gama Carvalho, Sarah A Teichmann, Luis Graca, Portugal

Workshop - TRACK 1 WS.T1.08 - Immune Response in Disease 09:30 – 10:45 | HALL 8 Chairs: Ivana STOJANOVIC, Serbia & Güher SARUHAN DIRESKENELI, Turkey ABO-group and age are individuals factors associated with specific T-cell memory in long-term immunity after COVID-19 Sergio Gil Manso, Iria Miguens, Rocio Lopez Esteban, Diego Carbonell Muñoz, Luis Lopez, Anne Halpin, Bruce Motyka, Lori West, Rafael Correa Rocha, Marjorie Pion, Spain NKG2A and HLA-E define an additional immune checkpoint axis in bladder cancer Bérengère Salomé, John P. Sfakianos, Jorge Daza, Andrew Charap, Adam M. Farkas, Daniel Geanon, Geoffrey Kelly, Ronaldo M. De Real, Brian Lee, Kristin G. Beaumont, Sanjana Shroff, Ying Chih Wang, Yuan Shuo Wang, Li Wang, Robert P. Sebra, Pedro Romero, Rachel Brody, Mary Carrington, Peter Wiklund, Reza Mehrazin, Matthew D. Galsky, Nina Bhardwaj, Amir Horowitz, United States High dimensional analysis of the human lymph node during melanoma progression reveals shifts in myeloid content that relate to differential T cell content Anastasia Prokopi, Dorian A. Stolk, Jan Verhoeff, Sinéad M. Lougheed, Marta Lopez Gonzalez, Lotte S. Groen, Tereza Brachtlova, Rieneke Van De Ven, Juan J. Garcia Vallejo, Patrizia Stoitzner, Tanja D. De Gruijl, The Netherlands Themis1/vav1 signaling hub controls t cell pathogenicity in a mouse model of multiple sclerosis Rémi Marrocco, Isabelle Cadenat, Renaud Lesourne, Abdelhadi Saoudi, France Distinct roles of foxp3+ regulatory T cell sublineages in adipose tissue homeostasis and obesity Acelya Yilmazer Kirgin, Marie Boernert, David Voehringer, Adrian Liston, Susan Schlenner, Karsten Kretschmer, Germany Insufficient up-regulation of YB-1 leads to failed CD4+ T cell survival of patients with SLE Stefan Meltendorf, Hang Fu, Mandy Pierau, Jonathan A. Lindquist, Stephanie Fienzel, Peter R. Mertens, Steffi Gieseler Halbach, Andreas Ambach, Ulrich Thomas, Holger Lingel, Reinhard E. Voll, Monika C. Brunner Weinzierl, Germany Role of treg/Th17 imbalance at the immunity or tolerance in myasthenia gravis Ilayda Altınönder, Mustafa Kaya, Sibel P. Yentür, Hacer Durmuş Tekçe, Berker Özkan, Gülçin Yeğen, Yeşim Parman, Güher Saruhan Direskeneli, Turkey

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Workshop - TRACK 3 WS.T3.07 - Immune Regulation in Cancer 09:30 – 10:45 | HALL 9 Chairs: Cecilia GARLANDA, Italy & Cem AR, Turkey Immune profiling of soft tissue sarcoma: cellular, proteomic and transcriptomic analysis of peripheral blood Paulo Rodrigues Santos, Jani Sofia Almeida, Patrícia Couceiro, Luana Madalena Sousa, Tânia Fortes Andrade, Ruben Fonseca, Paulo Freitas Tavares, José Manuel Casanova, Manuel Santos Rosa, Portugal Combination therapy of CAR-NK-cells and anti-PD-1 antibody results in high efficacy against advanced- stage glioblastoma in a syngeneic mouse model and induces protective anti-tumor immunity in vivo Florian Strassheimer, Maja Strecker, Tijna Alekseeva, Jadranka Macas, Melanie Demes, Iris Mildenberger, Torsten Tonn6, Peter Wild, Lisa Sevenich, Yvonne Reiss, Patrick Harter, Karlheinz Plate, Winfried Wels, Joachim Steinbach, Michael Burger, Germany СD14low16highHLA-DR+ monocytes are increased in breast cancer patients with good response to neoadjuvant chemotherapy Marina Patysheva, Evgeniya Grigoryeva, Irina Larionova, Marina Stakheyeva, Christel Weiss, Natalia Tarabanovskaya, Evtina Anastasia, Nadezhda Cherdyntseva, Julia Kzhyshkowska, Russia Cytokine-producing tumor-infiltrating lymphocyte products can be effectively generated from pre-treated late stage non-small-cell lung cancer (NSCLC) lesions irrespective of location and pre- treatment regimens Rosa De Groot, Suzanne M Castenmiller, Aurélie Guislain, Egbert F Smit, Kim Monkhorst, Koen J Hartemink, John B A G Haanen, Monika C Wolkers, Netherlands Downregulation of A20 promotes immune escape of lung adenocarcinomas Monika Homolya, Andreea Corina Luca, Kristina Breitenecker, Veronika Lang, Christoph Trenk, Jaqueline Horvath, Margarita Kurnaeva, Judit Moldvay, Emilio Casanova, Herwig Moll, Austria Single cell spatial analysis reveals changes in the tissue immune landscape during initiation of colitis associated cancer in patients Matthijs Jd Baars, Neeraj Sinha, José Ter Linde, Pascalle Hemelop, Mojtaba Amini, Miangela Laclé, Bas Oldenburg, Yvonne Vercoulen, The Netherlands IL-1R8 acts as an immune checkpoint in CD8+ T cells Domenico Supino, Andrea Mariancini, Chiara Perucchini, Silvia Carnevale, Andrea Ponzetta, Roberta Carriero, Federico Colombo, Elena Magrini, Sabrina Di Marco, Anna Rigatelli, Luna Cordeiro, Martina Molgora, Sarah Mapelli, Alessia Donato, Sarah Tettamanti, Andrea Biondi, Enrico Lugli, Sebastien Jaillon, Alberto Mantovani, Cecilia Garlanda, Italy

Workshop - TRACK 3 WS.T3.17 - Viral Immunology 2 09:30 – 10:45 | HALL 10 Chairs: Esin AKTAS, Turkey & Bojan POLIC, Croatia mTOR inhibitors prevent CMV infection through the restoration of functional gamma-delta and alpha- beta T cells in kidney transplantation Hannah Kaminski, Gabriel Marseres, Nathalie Yared, Vincent Pitard, Lionel Couzi, Pierre Merville, Julie Déchanet Merville, France Type I interferon receptor-independent interferon-alpha induction upon infection with a variety of negative-strand RNA viruses Martina Anzaghe, Stefanie Kronhart, Marc A. Niles, Lena Höcker, Monica Dominguez, Georg Kochs, Zoe Waibler, Germany

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Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming Francesco Andreata, De Simone Giorgia, Bleriot Camille, Fumagalli Valeria, Laura Chiara, José Garcia- Manteiga, Di Lucia Pietro, Ficht Xenia, Guidotti Luca, Ginhoux Florent, Iannacone Matteo, Italy Dissecting the role of IFN- in antiviral CD4+ T cell fate Eleonora Sala, Marta Mangione, Eleonora Consolo, Matteo Iannacone, Mirela Kuka, Italy 훾 Obesity is associated with an altered baseline and post-vaccination influenza antibody repertoire Marwa Abd Alhadi, Lilach Friedman, Erik Karlsson, Liel Cohen Lavi, Anat Burkovitz, Stacey Schultz Cherry, Terry Noah, Samuel Weir, Lester Shulman, Melinda Beck, Tomer Hertz, Israel Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets Alexander P Bye, Willianne Hoepel, Joanne L Mitchell, Sophie Jégouic, Silvia Loureiro, Tanya Sage, Steven De Taeye, Marit Van Gils, Neline Kriek, Nichola Cooper, Ian Jones, Jeroen Den Dunnen, Jonathan M Gibbins, United Kingdom A rapid screening strategy identifies a pan-coronavirus neutralizing antibody Jun Siong Low, Josipa Jerak, Dora Pinto, Antonino Cassotta, Mathilde Foglierini, Philipp Paparoditis, David Jarrossay, Federico Mele, Daniela Vaqueirinho, Tatiana Terrot, Alessandra Franzetti Pellanda, Maira Biggiogero, Christian Garzoni, Paolo Ferrari, Alessandro Ceschi, Davide Corti, David Veesler, Antonio Lanzavecchia, Federica Sallusto, Switzerland

yEFIS Symposium 11:00 – 12:45 | HALL 1 Should I stay or should I go - navigating the rough seas of career choices Chairs: Sophie CURIO, Australia & Rami BECHARA, France Panelists: Alexandra FLEMMING, United Kingdom Kat ARNEY, United Kingdom Andreas RADBRUCH, Germany Jonas BUNIKIS, Belgium Ben BLEASDALE, United Kingdom Nilesh AMATYA, United States

The EFIS Vaccine Task Force Panel: 13:15 – 14:15 | HALL 5 Challenges and opportunities for vaccine engagement across Europe Chair: Doug BROWN, United Kingdom Co-Chair: Ursula WIEDERMANN- SCHMIDT, Austuria Panelists: Aurelija ZVIRBLIENE, Lithuania Felix WENSVEEN, Croatia Peter OPENSHAW, United Kingdom Anne SPURKLAND, Norway

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JS - Joint Symposium with the American Association of Immunologists – AAI Microbiome-Host Interactions and Their Therapeutic Applications 14:30 – 15:45 | HALL 1 Chairs: Cathryn NAGLER, USA & Thomas KAMRADT, Germany Regulation of Allergic Responses to Food By Intestinal Bacteria Cathryn NAGLER, USA Regulation of Obesity By Microbe-Immune Interactions June L. ROUND, USA Regulation of Inflammatory Diseases By The Microbiota Neil SURANA, USA

JS - Joint Symposium with the International Society on Advancement of Cytometry – ISAC Cytometry for Fighting COVID-19 14:30 – 15:45 | HALL 2 Chairs: Andreas RADBRUCH, Germany & Jonni MOORE, USA Cytometry and ISAC: A Translational Approach to COVID Attila TARNOK, Germany High Parameter Immune Analysis of COVID-19 Patients to Identify Immune Correlates of Disease and New Therapeutic Opportunities Pratip CHATTOPADHYAY, USA T-REX: Machine Learning Reveals Virus-Specific Cells in Longitudinal Immune Monitoring Cytometry Jonathan IRISHI, USA

JS - Joint Symposium with the Russian Society of Immunology – RSI and Russian Association of Allergy and Clinical Immunology – RAACI Pearls of Russian Immunology 14:30 – 15:45 | HALL 3 Chairs: Alexander KARAULOV, Russia & Rudolf VALENTA, Austria siRNA-Based Approach for Treatment of COVID-19 Musa KHAITOV, Russia The Generation and Screening of Expanded Repertoires, the Lesson of the Analysis of Big Data Alexander GABIBOV, Russia Deciphering Cytokine Functions through Technologies of Reverse Genetics Sergei NEDOSPASOV, Russia

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JS - Joint Symposium with the European Society for Reproductive Immunology – ESRI

Feto-maternal Immune Crosstalk 14:30 – 15:45 | HALL 4 Chairs: Youla VARLA-LEFTHERIOTI, Greece & Udo R. MARKERT, Germany Innate Immune Cells in Pregnancy Youla VARLA-LEFTHERIOTI & Theodora KERAMITSOGLOU, Greece Vertically Transferred Immunity in Neonates: Mothers, Mediators & Mechanisms Petra C. ARCK & Ina STELZER, Germany Placenta-Immune Cell Communication Via Extracellular Vesicles and Non-Coding RNA Udo R. MARKERT & Diana M. MORALES-PRIETO, Germany

JS - Joint Symposium with Spanish – Iberoamerican Immunology Societies

Translational Immunotherapy in Cancer 14:30 – 16:15 | HALL 5 Chairs: Juliana IDOGAYA, USA and Jordi OCHANDO, Spain Building CD137-Based Cancer Immunotherapies Ignacio MELERO, Spain Tissue-Resident Macrophages Provide a Pro-Tumorigenic Niche to Early NSCLC Cells María CASANOVA-ACEBES, Spain Antigen Targeting to Dendritic Cells as a Way to Improve Vaccine Design Silvia BEATRIZ BOSCARDIN, Brazil Unraveling T Cell Memories Against Solid Tumors Alvaro LLADSER, Chile Role of Tissue Resident Memory T Cells with Progenitor Features in the Control of Melanoma Growth Laura C BONIFAZ, Mexico The Sweet Revolution: Glycans and Glycan-Binding Proteins in Tumor Immunity, Autoimmunity and Inflammation Gabriel RABINOVICH, Argentina

BRIGHT SPARKS WORKSHOP - TRACK 3 BS.T3.01 Diseases and Immune Responses 14:30 – 15:45 | HALL 6 Chairs: Fiona CULLEY, United Kingdom & Gerhard WINGENDER, Turkey Protective role of the nucleic acid sensor STING in idiopathic pulmonary fibrosis Nicolas Riteau, Florence Savigny, Sandra Carignon, Sarah Huot Marchand, Eric Kaya, Bernhard Ryffel, Aurélie Gombault, Marc Le Bert, Isabelle Couillin, France Tumour derived microRNA-21 reprograms macrophage responses Sarah Case, Poole Sorcha, Prendeville Hannah, Holmes Emily, Hackett Emer, Dalal Almuaili, Cliona O’farrelly, Frederick Sheedy, Ireland

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High-throughput single-cell analysis revealed transcriptional response of dendritic cell subsets during SARS-CoV-2 infection Giulia Protti, Laura Marongiu, Fabio Alessandro Facchini, Mihai Valache, Francesca Mingozzi, Valeria Ranzani, Anna Rita Putignano, Lorenzo Salviati, Valeria Bevilacqua, Serena Curti, Mariacristina Crosti, Mariella D’angiò, Laura Rachele Bettini, Andrea Biondi, Luca Nespoli, Nicolò Tamini, Nicola Clementi, Nicasio Mancini, Sergio Abrignani, Roberto Spreafico, Francesca Granucci , Italy Rescue of STAT3 function in hyper-IgE syndrome using adenine base editing Andreas C Eberherr, Andre Maaske, Christine Wolf, Florian Giesert, Riccardo Berutti, Ejona Rusha, Anna Pertek, Miriam T Kastlmeier, Carola Voss, Michelle Plummer, Amina Sayed, Elisabeth Graf, Renate Effner, Thomas Volz, Micha Drukker, Tim M Strom, Thomas Meitinger, Tobias Stoeger, Alena M Buyx, Ellen D Renner, Beate Hagl , Germany TIGIT expression differentiates regulatory from inflammatory non-classical Th1-like gut-homing effector CD4+ T cells in inflammatory bowel disease patients Maud Heredia, Léa M.M. Costes, Irma Tindemans, Martine A. Aardoom, Renz C.W. Klomberg, Polychronis Kemos, Maria E. Joosse, Daniëlle H. van Haaften, Bastiaan Tuk, Frank Ruemmele, Nick Croft, Johanna C. Escher, Lissy de Ridder, Janneke N. Samsom, Netherlands Pediococcus pentosaceus derived membrane vesicles modulate inflammation by generating M2-like macrophages and myeloid-derived suppressor cells Esin Alpdundar Bulut, Banu Bayyurt Kocabas, Volkan Yazar, Gamze Aykut, Ulku Guler, Bekir Salih, Naz Surucu Yilmaz, Ihsan Cihan Ayanoglu, Muammer Merve Polat, Kamil Can Akcali, Ihsan Gürsel, Mayda Gürsel, Turkey

Workshop - TRACK 1 WS.T1.04 - Innate Lymphoid Cell 14:30 – 15:45 | HALL 8 Chairs: Carsten WATZL, Germany& Gunnur DENIZ, Turkey NKG2D ligand recognition by γδ T cells drives steatohepatitis and fibrosis in MAFLD Sonja Marinović, Maja Lenartić,t4 Marko Šestan, Inga Kavazović, Ante Benić,Karlo Mladenić, Mia Krapić, Tamara Turk Wensveen, Dora Fučkar Čupić, Ivana Mikolašević, Lidija Bilić Zulle, Adrian Hayday, Felix Martinus Wensveen, Bojan Polić, Croatia MicroRNA-142 is a critical regulator of group 2 innate lymphoid cell homeostasis and function Luke B Roberts, Geraldine M Jowett, Emily Read, Rita Berkachy, Murray E Selkirk, Umar Niazi, Nelomi Anandagoda, Chela James, Rachael Nimmo, Jane K Howard, Joana F Neves, Graham M Lord, United Kingdom Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer Jeremy Goc, Mengze Lv, Nicholas J. Bessman, Anne Laure Flamar, Sheena Sahota, Hiroaki Suzuki, Fei Teng, Gregory G. Putzel, Gerard Eberl, David R. Withers, Janelle C. Arthur, Manish A. Shah, Gregory F. Sonnenberg, United States Identification and characterisation of novel NK cell-restricted aceNK progenitors Noe Rodriguez Rodriguez, Jillian L. Barlow, Paula A. Clark, Mayuri Gogoi, Helen E. Jolin, Meera Sivasubramaniam, Luisa Pedro, Jennifer A. Walker, Morgan W. D. Heycock, Jacqueline D. Shields, Andrew N. J. Mckenzie, United Kingdom TET2/IDH mutations in myelodysplastic syndrome patients disrupts natural killer cell’s biology Maxime Boy, Valeria Bisio, Lin Pierre Zhao, Emilie Lereclus, Fabien Guidez, Christelle Retiere, Emmanuelle Clappier, Karl Balabanian, Antoine Toubert, Pierre Fenaux, Lionel Ades, Nicolas Dulphy, France

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Characterization of human innate lymphoid cell subsets in healthy lymph nodes Louise Rethacker, Maxime Boy, France Roussin, Antoine Toubert, Nicolas Dulphy, Anne Caignard, France Adaptive-like NK cell responses are composed of circulating and resident lineages Sophie Flommersfeld, Jan P. Böttcher, Jonatan Ersching, Michael Flossdorf, Philippa Meiser, Ludwig O. Pachmayr, Justin Leube, Inge Hensel, Sebastian Jarosch, Qin Zhang, M. Zeeshan Chaudhry, Immanuel Andrä, Matthias Schiemann, Dirk H. Busch, Luka Cicin Sain, Joseph C. Sun, Georg Gasteiger, Gabriel D. Victora, Thomas Höfer, Veit R. Buchholz, Simon Grassmann, Germany

Workshop - TRACK 3 WS.T3.16 - Viral Immunology 1 14:30 – 15:45 | HALL 9 Chairs: Alemka MARKOTIĆ, Croatia & Maria MONTOYA, Spain Group 1 innate lymphoid cells regulate T cell-mediated liver immunopathology by controlling local interleukin-2 availability Valeria Fumagalli, Valentina Venzin, Pietro Di Lucia, Federica Moalli, Xenia Ficht, Gioia Ambrosi, Leonardo Giustini, Francesco Andreata, Marta Grillo, Micol Rava, Christin Friedrich, Jason D. Fontenot, Philippe Bousso, Georg Gasteiger, Eric Vivier, Mirela Kuka, Luca G. Guidotti, Matteo Iannacone, Italy Highly efficient CRISPR-Cas9-mediated gene knockout in primary human B cells for functional genetic studies of Epstein-Barr virus infection Ezgi Akidil, Manuel Albanese, Alexander Buschle, Adrian Ruhle, Dagmar Pich, Oliver T Keppler, Wolfgang Hammerschmidt, Germany Hepatitis B virus negatively impacts the protective Immune crosstalk between Natural Killer and Dendritic Cells Claudia De Pasquale, Stefania Campana, Chiara Barberi, Giacomo Sidoti Migliore, Daniela Oliveri, Marika Lanza, Cristina Musolino, Giovanni Raimondo, Soldano Ferrone, Teresa Pollicino, Guido Ferlazzo, Italy Loss of skin CXCR3+ CD4+ tissue-resident T cells causes irreversible skin-confined immunodeficiency in HIV late presenters Simona Saluzzo, Ram Vinay Pandey, Laura Marie Gail, Ruth Dingelmaier Hovorka, Lisa Kleissl, Bärbel Reininger, Denise Atzmüller, Johanna Strobl, Veronique Touzeau Römer, Andrea Beer, Clement Staud, Armin Rieger, Matthias Farlik, Wolfgang Weninger, Georg Stingl, Georg Stary, Austria A two-photon imaging platform for investigating cytotoxic T lymphocyte dynamics in virus-infected explanted lungs Laura Ospina Quintero, Berislav Bosnjak, Yvonne Lueder, Christiane Ritter, Martin Messerle, Stephan Halle, Reinhold Förster, Germany CD8+ lymphocyte mediated suppression of HIV expression in CD4+ T cells Lavinia Franchitti, Ashish Arunkumar Sharma, Jack Yoon, Erick White, Zhan Zhang, Hong Wang, Maura Statzu, Abigail E Willemse, Lisa Bateganya, Guido Silvestri, Deanna Kulpa, United States IgA immune history profiles predict influenza disease in vaccinated and unvaccinated individuals Ayelet Shagal, Lilach M. Friedman, Joshua Petrie, Youyi Fong, Erik Karlsson, Emily T. Martin, Paul G, Thomas, Peter Gilbert, Arnold M. Monto, Tomer Hertz, Israel

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Workshop - TRACK 3 WS.T3.18 - COVID 19 – 1 14:30 – 15:45 | HALL 10 Chairs: Ihsan GURSEL, Turkey & Stipan JONJIC, Croatia Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019 Seppe Cambier, Mieke Metzemaekers, Marfa Blanter, Jennifer Vandooren, Ana Carolina de Carvalho, Bert Malengier-Devlies, Lore Vanderbeke, Cato Jacobs, Sofie Coenen, Alexandre Borin, Stéfanie Primon Muraro, Gabriela Fabiano de Souza, the CONTAGIOUS consortium, Pedro Elias Marques, Carine Wouters, Els Wauters, Sofie Struyf, Patrick Matthys, Ghislain Opdenakker, Rafael Elias Marques, Joost Wauters, Mieke Gouwy, Paul Proost, Belgium Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity Sara Falck Jones, Sindhu Vangeti, Meng Yu, Ryan Falck Jones, Alberto Cagigi, Isabella Badolati, Björn Österberg, Maximilian Julius Lautenbach, Eric Åhlberg, Karin Loré, Anna Färnert, Anna Smed Sörensen, Sweden Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Anna C. Aschenbrenner, Maria Mouktaroudi, Benjamin Krämer, Marie Oestreich, Nikolaos Antonakos, Melanie Nuesch-Germano, Konstantina Gkizeli, Lorenzo Bonaguro, Nico Reusch, Kevin Baßler, Maria Saridaki, Rainer Knoll, Tal Pecht, Theodore S. Kapellos, Mihai G. Netea, Joachim L. Schultze, Matthijs Kox, Monique M.B. Breteler, Jacob Nattermann, Antonia Koutsoukou, Evangelos J. Giamarellos- Bourboulis, Thomas Ulas, German COVID-19 Omics Initiative (DeCOI), Germany Infection and transmission of SARS-CoV-2 depends on heparan sulfate proteoglycans Julia Eder, Marta Bermejo Jambrina, Tanja Kaptein, John Van Hamme, Leanne Helgers, Killian Vlaming, Philip Brouwer, Alexander Vlaar, Frank Van Baarle, Marcel Spaargaren, Godelieve De Bree, Bernadien Nijmeijer, Neeltje Kootstra, Marit Van Gils, Rogier Sanders, Teunis Geijtenbeek, Netherlands Identification of SARS-CoV-2-cross-reactive resident memory CD8+ T cells in oropharyngeal lymphoid tissue Julia Niessl, Takuya Sekine, Joshua Lange, Viktoria Konya, Marianne Forkel, Jovana Maric, Anna Rao, Luca Mazzurana, Efthymia Kokkinou, Johan Fehrm, Joar Sundman, David A. Price, Emma B. Hodcroft, Richard A. Neher, Jenny Mjösberg, Danielle Friberg, Marcus Buggert, Sweden The distribution of mature and/or immature myeloid cells and their role in effective anti-viral immune responses in COVID-19 positive patients Digdem Yoyen Ermis, Fatma Dombaz, Mehmet Karacay, Onur Etgu, Muhammed Ali Kizmaz, Abdurrahman Simsek, Eren Cagan, Ali Asan, Emel Yilmaz, Esra Kazak, Ibrahim Ethem Pinar, Salih Haldun Bal, Gözde Arslan, Mert Karaca, Vildan Özkocaman, Fahir Özkalemtaş, Emin Halis Akalın, Ferah Budak, Haluk Barbaros Oral, Turkey Changes in circulating monocytes predict severity during acute COVID-19 and include chromatin modifications still detectable six months after recovery Alberto Utrero Rico, Cecilia Gonzalez Cuadrado, Marta Chivite Lacaba, Oscar Cabrera Marante, Rocio Laguna Goya, Patricia Almendro Vazquez, Carmen Diaz Pedroche, Maria Ruiz Ruigomez, Antonio Lalueza, Maria Dolores Folgueira, Enrique Vazquez, Ana Quintas, Marcos Berges Buxeda, Moises Martin Rodriguez, Ana Dopazo, Antonio Serrano Hernandez, Jose Maria Aguado, Estela Paz Artal, Spain

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PL.3 Damage, Defense and Adaptation – How the Immune System Ages Janko NIKOLICH-ZUGICH, USA 16:15 – 17:00 | HALL 1 Chairs: Djordje MILJKOVIC, Serbia & Clare BRYANT, United Kingdom S1.5 – EFIS-IL: B Cell Differentiation and Function in Health and Disease 17:15 – 18:30 | HALL 1 Chairs: Jitka FUCIKOVA, Czech – Republic & Chrysoula NIKOLAOU, Greece Molecular Mechanisms Regulating B Cell Survival in Health and Disease Idit SHACHAR, Israel Siglecs: Inhibitors of B Cell Responses and Leukemia Progression Lars NITSCHKE, Germany New Insights into Mucosal Antibody Responses Andrea CERUTTI, Spain

S2.4 – COVID-19 Vaccine Development and Regulatory Issues: 17:15 – 18:30 | HALL 2 What We Have Learnt from the Pandemics? Chairs: Stefan KAUFMANN, Germany & Selim BADUR, Turkey T Cell Responses of COVID-19 Patients Grigory EFIMOV, Russia Vaccine Development and Fair Distribution Efforts during COVID-19 Pandemic Peter HOTEZ, USA Covid Vaccines & Regulatory Issues Phil KRAUSE, USA

MS3.3 – Autoimmune Diseases 17:15 – 18:45 | HALL 3 Chairs: Renato MONTEIRO, France & Barbaros ORAL, Turkey Neuropathology of Antibody-Associated Autoimmune Diseases of the Brain Romana HOEFTBERGER, Austria T Cell-Phagocyte Crosstalk in Chronic Inflammation Burkhard BECHER, Switzerland Myeloid Cell Diversity during Neuroinflammation Marco PRINZ, Germany

MS4.3 – New Technologies in Immunology Research 17:15 – 18:45 | HALL 4 Chairs: Daniela BOSISIO, Italy & Christoph BOCK, Austria Decoding the Developing Human Immune System Muzlifah HANIFFA, United Kingdom Cell Atlas Technologies to Decipher Immunity Sarah TEICHMANN, United Kingdom Looking into the Past and Future of Cells: Single-Cell Analysis of Epigenetic Cell States in Immunology and Cancer Christoph BOCK, Austria

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Women and Men in Immunology 17:15 – 18:45 | HALL 5 Chairs: Olivera FINN, USA & Talal CHATILA, USA Dissecting Immune Response to SARS-CoV-2 Akiko IWASAKI, USA Why the COVID Pandemic Has Affected so Much Research Work among Women Paola RICCIARDI-CASTAGNOLI, Italy Isil Berat Barlan Awards Ceremony

Best Poster Session Track 4 BP.T4.01 - Innovative Technologies and Immunotherapies 17:15 – 18:30 | HALL 6 Chairs: Emin KANSU, Turkey & Marieke VAN HAM, The Netherlands The Jury will make their nominations for the Best Poster session after pre-viewing of posters in the E-poster Hall. Therefore, the line up of Best Poster presenters will not be available until August 31st. You may view the line-up on the congress web platform once it is announced. Workshop - TRACK 4 WS.T4.02 - Cancer Immunotherapy - Adaptive Immune Responses 17:15 – 18:30 | HALL 7 Chairs: Banu BAYYURT KOCABAS, Turkey & Anna Maria GEORGOUDAKI, The Netherlands Antioxidant empowerment enhances antitumor functions of HER2-specific CAR T cells Emre Balta, Nina Janzen, Henning Kirchgessner, Christian Orlik, Jie Liang, Niesler Beate, Thomas Ruppert, Yvonne Samstag, Germany Microbial short-chain fatty acids enhance CD8+ T cell-mediated cancer immunotherapy Maik Luu, Zeno Riester, Adrian Baldrich, Anne Wempe, Sophia Danhof, Thomas Nerreter, Imke E Mulder, Ulrich Steinhoff, Michael Hudecek, Alexander Visekruna, Germany Toll-like receptor ligand inclusion in GM3-containing liposomes induces potent dendritic cell maturation and T cell responses Maarten K. Nijen Twilhaar, Lucas Czentner, Joanna Grabowska, Alsya J. Affandi, Katarzyna Olesek, Rianne Bouma, Hakan Kalay, Saskia Belt, Yvette van Kooyk, Gert Storm, Joke M.M. den Haan, Netherlands Anti-tumor properties of epitope-specific vaccine in murine model of melanoma Emiliya Stoyanova, Nikolina Mihaylova, Iliyan Manoylov, Krassimira Idakieva, Andrey Tchorbanov, Bulgaria Patient-specific cellular models for Sézary syndrome immunotherapy Rebeca F Megino, Raquel G Laborda, Daniel Chacon-Arguedas, Ana V Marin, Karen Arias-Jimenez, José R Regueiro, Spain Modeling of dendritic cell vaccines for ovarian cancer immunotherapy using cell lines of different molecular profiles Agata Mlynska, Egle Zymantaite, Emilija Paberale, Jan Aleksander Krasko, Vita Pasukoniene, Lithuania Low frequency of differentiated CD3+CD27-CD28- T cells at enrollment predicts a favorable response to CAR T cell therapy in patients with DLBCL Katharina Grabmeier Pfistershammer, Nina Worel, Marion Heinz, Martina Schlager, Andreas Tanzmann, Arno Rottal, Ulrike Körmöczi, Bernhard Kratzer, Edit Porpaczy, Philipp Staber, Cathrin Skrabs, Harald Herkner, Nora Saxenhuber, Philipp Wohlfarth, Georg Hopfinger, Werner Rabitsch, Ingrid Simonitsch Klupp, Ulrich Jaeger, Winfried F Pickl, Austria

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Workshop - TRACK 1 WS.T1.10 - T Lymphocyte Regulation and Function 17:15 – 18:30 | HALL 8 Chairs: Aideen RYAN, Ireland & Tolga SUTLU, Turkey Retaining memory: virtual memory CD8+ T cells as an adaptive mechanism of the ageing immune system Mariana Borsa, Annette Oxenius, United Kingdom T cell stemness during chronic infection is maintained by only a subcompartment of TCF1+ cells Lorenz Kretschmer, Svenja Rapelius, Sebastian Jarosch, Anton Mühlbauer, Dietmar Zehn, Veit Buchholz, Germany Protein tyrosine phosphatase non-receptor type 2 and killer cell lectin-like receptor G1 regulate the generation and function of tissue-resident memory T cells in skin Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias Hans Enders, Moshe Olshansky, Brendan Russ, Claerwen Jones, David Gyorki, Stephen Turner, Marco Herold, Tony Tiganis, Sammy Bedoui, Thomas Gebhardt, Australia HDAC7 controls CD8+ T cell dependent anti-viral and anti-tumor immunity Cansu Yerinde, Jacqueline Keye, Sibel Durlanik, Inka Freise, Franziska Schmidt, Stephan Schlickeiser, Benedikt Obermayer, Marie Friedrich, Hao Wu, Désirée Kunkel, Anja Kühl, Sebastian Bauer, Andreas Thiel, Britta Siegmund, Rainer Glauben, Carl Weidinger,Germany Bryostatin exerts anti-tumor effects by reversing T cell exhaustion Manzhi Zhao, Ling Li, Caoimhe H Kiernan, Rik Ruijten, Tessa Alofs, Marjan Van Meurs, Inge Brouwers Haspels, Yvonne M Mueller, Peter D Katsikis, Netherlands Cooperation between chemotherapy and immunotherapy to enhance anti-tumour T-cell mediated immunity in oesophageal adenocarcinoma; implications for synergistic combination regimens Maria Davern, Noel E Donlon, Andrew Sheppard, Fiona O Connell, Conall Hayes, Ross King, Hugo Temperley, Jenny Moore, Christine Butler, Anshul Bhardwaj, Michael Maclean, Gillian Cotter, Narayanasamy Ravi, John V Reynolds, Stephen G Maher, Melissa J Conroy, Joanne Lysaght, Ireland Single-cell chimerism analysis and transcriptional profiling identify long-term human tissue-resident host T cells in the skin after allogeneic stem cell transplantation Gustavo Almeida, Tonio Brinkschmidt, Chang Feng Chu, Christina Zielinski, Germany

Workshop - TRACK 3 WS.T3.12 - Mucosal Immunity 17:15 – 18:30 | HALL 9 Chairs: Jelena DJOKIC, Serbia & Martin LARSEN, France GATA6 deficiency leads to epithelial barrier dysfunction and enhances susceptibility to gut inflammation Federica Laudisi, Carmine Stolfi, Gerolamo Bevivino, Claudia Maresca, Eleonora Franzè, Edoardo Troncone, Elisabetta Lolli, Daniele Pietrucci, Adelaide Teofani, Alessandro Desideri, Ivan Monteleone, Giovanni Monteleone, Italy Store-operated calcium entry controls immune cell function and activation in inflammatory bowel disease Marilena Letizia, Ulirike Kaufmann, Lorenz Gerbeth, Annegret Sand, Max Brunkhorst, Yinhu Wang, Chotima Böttcher, Stephan Schlickeiser, Camila Fernández Zapata, Desirée Kunkel, Ibdome Researchers, Britta Siegmund, Stefan Feske, Carl Weidinger, Germany Expression of the coinhibitory receptor TIGIT on memory CD4+ T cells is induced by TCR ligation and retinoic acid co-stimulation and is elicited during microbial colonization of the intestine Daniëlle M.H. Barendregt, Linda M.E. Joosse, Lisette A. van Berkel, Anne van Schoonhoven, Janneke N. Samsom, The Netherlands 6th European Congress of Immunology, September 1-4, 2021 68 Friday, September 3, 2021

Early-life vitamin A treatment rescues neonatal infection-induced long-lastingly impaired lymph node operativeness Mangge Zou, Joern Pezoldt, Jens Raila, Carolin Wiechers, Juliane Mohr, Juhao Yang, Michael Beckstette, Lianxu Hao, Aline Dupont, Mathias Hornef, Till Strowig, Petra Dersch, Andreas Mueller, Jochen Huehn, Germany Arginase 1 inhibits the resolution of colitis due to the consumption of L-arginine and the expansion of an inflammatory microbiota Jochen Mattner, Manfred Rauh, Benjamin Schmid, Arif Ekici, Arndt Hartmann, Peter Oefner, Raja Atreya, Stefan Wirtz, Christian Bogdan, Germany Identification of a disease-associated network of intestinal immune cells in treatment-naïve inflammatory bowel disease Laura F. Ouboter, Vincent Van Unen, Na Li, Tamim Abdelaal, Yvonne Kooy Winkelaar, Mette Schreurs, M. Luisa Mearin, Anne M. C. Witte, Hankje C. Escher, Andrea E. Van Der Meulen De Jong, M. Fernanda Pascutti, Frits Koning, Netherlands Immune checkpoint inhibitor-induced colitis is mediated by IL23 responsive CD90+ cytotoxic lymphocytes Jonathan Wai Pang Lo, Domenico Cozzetto, Jillian Yong Xin Sieh, James L Alexander, Jesus Miguens Blanco, Matthew Madgwick, Tamas Korcsmaros, Hiromi Kudo, Robert Goldin, Julian Marchesi, Graham M Lord, Nick Powell, United Kingdom

Workshop - TRACK 3 WS.T3.14 - Tumor microenvironment 17:15 – 18:30 | HALL 10 Chairs: Akif TURNA, Turkey & Anne CAIGNARD, France Neutrophils controlling the intestinal microbiota provide protection against colitis and colitis- associated colorectal cancer Silvia Carnevale, Andrea Ponzetta, Anna Rigatelli, Roberta Carriero, Domenico Supino, Simone Puccio, Fabio Pasqualini, Andrea Mariancini, Camilla Recordati, Claudio Tripodo, Elena Magrini, Luna Cordeiro Minute, Cecilia Garlanda, Alberto Mantovani, Sebastien Jaillon, Italy The T-cells Sweet Tooth: T-lymphocytes exposed to highly sialylated cancer associated fibroblasts present an exhausted phenotype, which can be reversed through desialylation Hannah Egan, Oliver Treacy, Niamh Leonard, Kevin Lynch, Amir Nader, Sean Hynes, Margaret Sheehan, Laurence J Egan, Thomas Ritter, John Daly, Aisling M Hogan, Michael O’Dwyer, Aideen E Ryan, Ireland Hindering triple negative breast cancer progression by targeting endogenous Interleukin-30 requires IFNγ signaling Luigi D’Antonio, Stefania Livia Ciummo, Cristiano Fieni, Scott Abrams, Zhinan Yin, Li-Fan Lu, Carlo Sorrentino, Emma Di Carlo, Italy Complementary but distinct protective roles of breast tumor-infiltrating IgG and IgA producing cells Yasmine Lounici, Coline Couillault, Justine Berthet, Vincent Alcazer, Olivia Le Saux, Ken Lo, John C Tan, Jigar Patel, Pauline Wajda, Sarah Barrin, Jonathan Lopez, Franceline Guillot, Amélie Colombe Vermorelle, Laetitia Odeyer, Isabelle Treilleux, Christophe Caux, Bertrand Dubois, France Tumor-associated macrophages heterogeneity is driven by distinct niches in breast cancer Marie Laviron, Maxime Petit, Eleonore Weber Delacroix, Alexis J Combes, Arjun Arkal Rao, Sandrine Barthelemy, Tristan Courau, David A Hume, Christophe Combadière, Matthew F Krummel, Alexandre Boissonnas, France

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Frequencies and functional properties of Innate Lymphoid Cells are altered in melanoma patients and modulated by immune checkpoints inhibitors Costanza Maria Cristiani, Carlo Sorrentino, Cinzia Garofalo, Mariaelena Capone, Luigi D’antonio, Gabriele Madonna, Domenico Mallardo, Cristiano Fieni, Marta Greco, Paolo Antonio Ascierto, Hergen Spits, Ennio Carbone, Italy Tumor-infiltrating plasmacytoid dendritic cells are associated with survival in human colon cancer Ioana Plesca, Maximilian Kießler, Ulrich Sommer, Rebekka Wehner, Friederike Wilczkowski, Luise Müller, Antje Tunger, Xixi Lai, Anke Rentsch, Kenneth Peuker, Sebastian Zeissig, Adrian M Seifert, Lena Seifert, Jürgen Weitz, Michael Bachmann, Martin Bornhäuser, Daniela Aust, Gustavo Baretton, Marc Schmitz, Germany

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Saturday, September 4, 2021

PL.4 Extracellular Vesicles in the Immune System 09:30 – 10:15 | HALL 1 Edit BUZAS, Hungary Chairs: Christine FALK,Germany & Marco Antonio CASSATELLA, Italy

S1.2 – Myeloid Cells 10:30 – 11:45 | HALL 1 Chairs: Trevor OWENS, Denmark & Ivana STOJANOVIC, Serbia Role of the Tetraspan MS4A4A Protein in Myeloid Cell Functions Massimo LOCATI, Italy The CD47-SIRP Alpha Myeloid Immune Checkpoint in Cancer Timo van den BERG, The Netherlands Hypoxia Neutrophils and Inflammation Sarah WALMSLEY, United Kingdom

S2.5 – EFIS-IL: Non-Coding RNA and Epigenetic Regulation 10:30 – 11:45 | HALL 2 in Immune Cells Chairs: Luljeta NEZIRI-AHMETAJ, Kosovo & Juergen WITTMANN, Germany MicroRNA-Mediated Regulation of Primary Human T Lymphocytes Silvia MONTICELLI, Switzerland The Macrophage Epigenome and the Control of Inflammatory Gene Expression Gioacchina NATOLI, Italy Regulation of Innate Immunity by Non-Coding RNAs Flavia BAZZONI, Italy

S3.2 – Aging of the Immune System 10:30 – 11:45 | HALL 3 Chairs: Rene VAN LIER, The Netherlands & Delphine SAUCE, France Impact of Inflammatory Status on Resilience in the Elderly Delphine SAUCE, France Role of Modified Proteodynamics in Aging of the Immune System and Its Consequences Jacek M. WITKOWSKI, Poland T Cells in Age-Related Disorders Maria MITTELBRUNN, Spain

S4.4 – Perspectives in Single Cell Analysis 10:30 – 11:45 | HALL 4 Chairs: Luis GRACA, Portugal & Muzlifah HANIFFA, United Kingdom Human Systems Immunology Petter BRODIN, Sweden Deep Immune Profiling of Exhausted and Resident T Cells by Mass Cytometry: Implications for Personalized Immunotherapy Bertram BENGSCH, Germany Deciphering the Transcriptional and Clonal Heterogeneity of Adaptive Immune Cells in Chronic Inflammation Mir-Farzin MASHREGHI, Germany

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Workshop - TRACK 2 WS.T2.06 - Immune Regulation and Big Data 10:30 – 11:45 | HALL 5 Chairs: Ahmet OZEN, Turkey & TBA BamQuery: A new proteogenomic tool to explore the immunopeptidome and validate tumor-specific antigens Maria Virginia Ruiz, Anca Apavaloaei, Qingchuan Zhao, Marie Pierre Hardy, Sebastien Lemieux, Claude Perreault, Gregory Ehx, Belgium Discovery of subtype specific markers through fuzzy logic and non-parametric approaches using Transcriptomic data in immune related Colon cancer Necla Koçhan, Emre Dayanç, Turkey Single-cell profiling of age-associated immunity in murine atherosclerosis Virginia Smit, Diede Smeets, Frank Schaftenaar, Fenne Verheijen, Laurens Bogers, Marie Depuydt, Rimke Postel, Jill De Mol, Janine Van Duijn, Robin Verwilligen, Wieke Grievink, Mireia Bernabe Kleijn, Julia Polansky, Menno De Winther, Christoph Binder, Ilze Bot, Dimitrios Tsiantoulas, Johan Kuiper, Amanda Foks, The Netherlands Identification of common metabolic markers of immune aging in Western European and African populations Ozlem Bulut, Godfrey S. Temba, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, Charlotte de Bree, Vera P. Mourits, Martin Jaeger, Jorge Dominguez-Andres, Andre J. van der Ven, Leo A.B. Joosten, Quirijn de Mast, Mihai G. Netea, Netherlands Natural human variation in multi-layered cohorts predicts the function of CRELD1: a novel regulator of immune homeostasis in mouse and human Lorenzo Bonaguro, Jonas Schulte Schrepping, Maren Köhne, Lisa Schmidleithner, Caterina Carraro, Stefanie Warnat Herresthal, Arik Horne, Rob Ter Horst, Martin Jaeger, Christine S. Falk, Yang Li, Elvira Mass, Marc Beyer, Souad Rahmouni, Michel Georges, Leo A. B. Joosten, Frank L. Van De Veerdonk, Mihai G. Netea, Kristian Händler, Sach Mukherjee, Thomas Ulas, Joachim L. Schultze, Anna C. Aschenbrenner, Germany Mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges Christos Nikolaou, Kerstin Muehle, Stephan Schlickeiser, Alberto Sada Japp, Nadine Matzmohr, Desiree Kunkel, Marco Frentsch, Andreas Thiel, Germany Multiplexed proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response Timurs Maculins, Erik Verschueren, Trent Hinkle, Patrick Chang, Cecile Chalouni, Shilpa Rao, Youngsu Kwon, Junghyun Lim, Anand Kumar Katakam, Ryan C. Kunz, Brian K. Erickson, Ting Huang, Meena Choi, Tsung Heng Tsai, Olga Vitek, Mike Reichelt, Yasin Senbabaoglu, Brent Mckenzie, John Rohde, Ivan Dikic, Donald S. Kirkpatrick, Aditya Murthy, United States

Workshop - TRACK 1 WS.T1.05 - Lymphocyte Differentiation 10:30 – 11:45 | HALL 6 Chairs: Francesca DI ROSA, Italy & Serkan BELKAYA, Turkey Temporal dissection of the T cell-intrinsic factors that maintain T follicular helper cell identity and germinal centers Dirk Baumjohann, Germany

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Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential Dakota Rogers, Heather J. Melichar, Johannes Textor, Judith N. Mandl, Canada Mobilization of tissue-resident memory CD4+ T lymphocytes and their contribution to a systemic secondary immune reaction Carla Cendón, Weijie Du, Pawel Durek, Yuk Chien Liu, Lindsay Serene, Gilles Gasparoni, Simon Reinke, Katherina Siewert, Mir Farzin Mashreghi, Kevin Thurley, Andreas Radbruch, Jun Dong, Germany Proteomic features reflecting unique properties of human thymus-derived and ex vivo regulatory T cells are not present in TGF-beta-induced regulatory T cells Mark Mensink, Sander de Kivit, Jannie Borst, Netherlands Akt modulates differentiation of CD8+ memory T cell precursor populations but is dispensable for translational regulation Gabriela Virdzekova, Anne Rogel, Thomas Bailey, Matthew Rose Zerilli, Stephen Thirdborough, Aymen Al Shamkhani, United Kingdom T regulatory cells oscillate between a TNF-producing and a TNFR2-expressing status Gloria Tucci, Marta Zagaglioni, Ilenia Pacella, Giovanna Peruzzi, Silvia Piconese, Italy Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity Yin Xiao, Musga Qureischi, Lena Dietz, Martin Vaeth, Subrahmanya D. Vallabhapurapu, Stefan Klein Hessling, Matthias Klein, Anika König, Edgar Serfling, Anja Mottok, Tobias Bopp, Andreas Rosenwald, Mathias Buttmann, Ingolf Berberich, Andreas Beilhack, Friederike Berberich Siebelt, Germany

Workshop – TRACK 3 WS.T3.04 - Exploiting Host Pathogen Interaction 10:30 – 11:45 | HALL 7 Chairs: Biljana Božić NEDELJKOVIĆ, Serbia & Babaros ORAL, Turkey The long pentraxin PTX3 at the host-pathogen interface in {Staphylococcus aureus}-dependent osteomyelitis Raffaella Parente, Valentina Possetti, Maria Lucia Schiavone, Masa Filipovic, Elisabetta Campodoni, Ciro Menale, Eleonora Palagano, Barbara Bottazzi, Monica Sandri, Anna Tampieri, Danka Grcevic, Alberto Mantovani, Antonio Inforzato, Italy Role of MHC class I-like XNC4 during mycobacterial infection in two developmental stages in {Xenopus} Matthieu Paiola, Sobhan Roy, Rhoo Kun Hyoe, Martin S. Pavelka, Erin J. Adams, Jacques Robert, United States Staphylococcus aureus-induced immunosuppression facilitates persistence during nasal colonisation Alanna M Kelly, Rachel M Mcloughlin, Ireland Prevention of Mycobacterium tuberculosis-induced neutrophil necrosis restricts bacterial proliferation and may represent a target for a host-directed therapy Tobias K Dallenga, Jacqueline Eich, Ulrich E Schaible, Germany Development and employment of a human cell-based in vitro {Mycobacterium avium} infection model to identify host-directed therapeutics as a novel treatment strategy Gül Kilinç, Anno Saris, Kees L.M.C. Franken, Tom H.M. Ottenhoff,Netherlands Neutrophil-dependent secretion of the biomarker LRG1 in Tuberculosis Julia Kutschenreuter, Jon S. Friedland, Deborah L. W. Chong, United Kingdom

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Cytomegalovirus subverts macrophage identity Sebastian Baasch, Piero Giansanti, Julia Kolter, André Riedl, Aaron James Forde, Solveig Runge, Simon Zenke, Roland Elling, Anne Halenius, Simone Brabletz, Hartmut Hengel, Bernhard Kuster, Thomas Brabletz, Luka Cicin Sain, Ramon Arens, Andreas Vlachos, Jan Rohr, Marc Stemmler, Manfred Kopf, Zsolt Ruzsics, Philipp Henneke, Germany

Workshop – TRACK 3 WS.T3.15 - Immunoregulation and Tumor microenvironment 10:30 – 11:45 | HALL 8 Chairs: Duygu SAG, Turkey & Audrey GERARD, United Kingdom Targeting PD1/PDL1 pathway by endogenous recombinant soluble PD1 Mussarat Wahid, United Kingdom Single-cell transcriptional and repertoire profiling of CD4+ TILs unveils distinct immune evasion strategies in primary and metastatic CRC Samuele Notarbartolo, Anna Rita Putignano, Raffaele Iannuzzi, Valeria Ranzani, Eugenia Galeota, Valeria Bevilacqua, Maria Lucia Sarnicola, Serena Curti, Paola Gruarin, Andrea Sartore Bianchi, Salvatore Siena, Alberto Bardelli, Massimiliano Pagani, Sergio Abrignani, Italy IL-17-producing CD8 T cells associate with poor survival in PDAC and promote carcinogenesis via induction of inflammatory cancer associated fibroblasts Felix Simon Ruben Picard, Veronika Lutz, Anna Brichkina, Anna Hupfer, Hartmann Raifer, Ho Ryun Chung, Philipp Mayer, Christian Bauer, Matthias Lauth, Matthias Gaida, Magdalena Huber, Germany Leukemic extracellular vesicles drive highly suppressive regulatory T cells by modulating mTOR and STAT5 signaling, leading to progression of myeloid leukemia Julian Swatler, Laura Turos Korgul, Marta Brewinska Olchowik, Sara De Biasi, Wioleta Dudka, Agata Kominek, Salwador Cyranowski, Jakub Mieczkowski, Elyas Mohammadi, Ewa Kozlowska, Andrea Cossarizza, Katarzyna Piwocka, Poland Alk4 disruption in Kras-induced pancreatic cancer remodels mechanical and immunologic properties of the tumor microenvironment Pia Gamradt, Sophie Bachy, Zhichong Wu, Kevin Thierry, Hector Hernandez Vargas, Richard Tomasini, Philippe Bertolino, Ana Hennino, France Depending on the tumor microenvironment, immunoproteasomes exert pro- or anti-tumorigenic effects Alexander Visekruna, Hanna Leister, Maik Luu, Ulrich Steinhoff, Germany Characterization of pre-existing and post-infectious immune responses to SARS-CoV-2 in cancer patients Tatjana Bilich, Malte Roerden, Yacine Maringer, Annika Nelde, Jonas S. Heitmann, Marissa L. Dubbelaar, Andreas Peter, Sebastian Hörber, Jens Bauer, Jonas Rieth, Marcel Wacker, Fiamma Berner, Lukas Flatz, Stefanie Held, Peter Brossart, Melanie Märklin, Philipp Wagner, Eva Erne, Reinhild Klein, Hans Georg Rammensee, Helmut R. Salih, Juliane S. Walz, Germany

Workshop - TRACK 3 WS.T3.19 - COVID 19 – 2 10:30 – 11:45 | HALL 9 Chairs: Maria NIKOLOVA, Bulgaria & Gunes ESENDAGLI, Turkey A colorimetric pseudovirus-based assay using secreted embryonic alkaline phosphatase for analysis of neutralizing activity against SARS-CoV-2 Cevriye Pamukcu, Mertkaya Aras, Elif Celik, Ebru Zeynep Ergun, Zeynep Sena Karahan, Tolga Sutlu, Turkey

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The influence of HLA genotype on the severity of COVID-19 infection Fatma Savran Oguz, Demet Kivanc, Cigdem Kekik Cinar, Hayriye Senturk Ciftci, Fatma Betul Oktelik, Murat Kose, Gunnur Deniz, Turkey The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses F. Konstantin Föhse, Busranur Geckin, Gijs J. Overheul, Josephine van de Maat, Gizem Kilic, Ozlem Bulut, Jacobien Hoogerwerf, Jaap ten Oever, Elles Simonetti, Frank L. van de Veerdonk, Leo A.B. Joosten, Bart L. Haagmans, Reinout van Crevel, Yang Li, Ronald P. van Rij, Corine GeurtsvanKessel, Marien I. de Jonge, Jorge Domínguez-Andrés, Mihai G. Netea, Netherlands Immunomodulatory effect of IgM/IgA-enriched high dose intravenous immunoglobulin therapy in COVID-19 Patients Milan Basta, Sergej Tomic, Natasa Ilic, Marina Bekic, Sofija Glamoclija, Radmila Karan, Natasa Kovacevic Kostic, Nemanja Dimic, Marko Djuric, Irina Nenadic, Marina Bobnos, Suzana Bojic, Aleksandra Ljubojevic, Duska Ignjatovic, Marija Djukanovic, Jelena Velickovic, Marija Cazic, Srdja Jankovic, Predrag Stevanovic, Ljiljana Sofronic Milosavljevic, Serbia Severe COVID-19 Is marked by a dysregulated myeloid cell compartment Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik, Kevin Baßler, Stephan Schlickeiser, Bowen Zhang, Benjamin Krämer, Tobias Krammer, Sophia Brumhard, Lorenzo Bonaguro, Elena De Domenico, Daniel Wendisch, Anna C. Aschenbrenner, Yang Li, Jacob Nattermann, Antoine Emmanuel Saliba, Leif Erik Sander, Joachim L. Schultze, Deutsche Covid 19 Omics Initiative Decoi, Germany Hyper-inflammation in severely ill COVID-19 is induced by early phase anti-SARS-CoV-2 IgG and can be specifically counteracted by FDA/EMA-approved small molecule inhibitors Chiara E. Geyer, Willianne Hoepel, Hung Jen Chen, Steven W. De Taeye, Lynn Mes, Gestur Vidarsson, Marit J. Van Gils, Menno De Winther, Jeroen Den Dunnen, Netherlands Peripheral CD39-expressing regulatory T cell subsets play an age-dependent role in the severity of COVID-19 Eren Cagan, Abdurrahman Simsek, Muhammed Ali Kizmaz, Fatma Dombaz, Gülcin Tezcan, Ali Asan, H. Ibrahim Demir, S. Haldun Bal, Digdem Yoyen Ermiş, Asli Gorek Dilektasli, Esra Kazak, E. Halis Akalin, Haluk Barbaros Oral, Ferah Budak, Turkey

Workshop - TRACK 3 WS. Diseases and Innovative Technologies 10:30 – 11:45 | HALL 10 Chairs: Ken ISHII, Japan & Sarah Doyle, Ireland The protective role of mast cells against neuroendocrine prostate cancer depends on the release of cytokines mediated by intracellular osteopontin Roberta Sulsenti, Valeria Cancila, Claudia Enriquez, Barbara Frossi, Renata Ferri, Laura Botti, Claudia Chiodoni, Carlo E Pucillo, Claudio Tripodo, Mario P Colombo, Elena Jachetti,Italy A novel monoclonal antibody (x-mAb) produced by a newly discovered lymphocyte (DE cells) identifies universal autoreactive T cells that are associated with self-related immunity Rizwan Ahmed, Zahra Omidian, Adebola Giwa, Neha Majety, Kagan Ege, Chunfa Jie, Thomas Donner, Abdel R. A. Hamad, United States Evolution of enhanced innate immune evasion in lung epithelial cells by the SARS-CoV-2 B.1.1.7 variant Lucy Thorne, Mehdi Bouhaddou, Ann Kathrin Reuschl, Lorena Zuliani Alvarez, Ben Polacco, Adrian Pelini, Jyoti Batra, Matthew V Whelan, Manisha Ummadi, Ajda Rojc, Jane Turner, Kirsten Obernier, Hannes Braberg, Ian Goodfellow, Natalia Jura, Klim Verba, Mahdad Noursadeghi, Pedro Beltrano, Danielle Swaney, Adolfo Garcia Sastre, Clare Jolly, Greg J Towers, Nevan J Krogan, United Kingdom

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3D human skin models of inflammatory skin diseases psoriasis and atopic dermatitis Jasmin Scheurer, Germany From bench to bedside – Clinical therapy with T regulatory cells Maciej Zielinski, Magdalena Zalinska, Dorota Iwaszkiewicz Grzes, Mateusz Gliwinski, Matylda Hennig, Anna Jazwinska Curyllo, Halla Kaminska, Justyna Sakowska, Anna Woloszyn Durkiewicz, Radoslaw Owczuk, Wojciech Mlynarski, Przemyslawa Jarosz Chobot, Artur Bossowski, Agnieszka Szadkowska, Janusz Siebert, Natalia Marek Trzonkowska, Malgorzata Mysliwiec, Piotr Trzonkowski, Poland Cellular response of HaCaT keratinocytes in co-culture with St. aureus in bacterial cellulose-based antibacterial wound dressings Sabriye Senem Kılıç, Sena Davran, Berna Alemdağ, Aslı Katmış, Semra Ünal, Burak Aksu, Faik Nüzhet Oktar, Turkey Novel adjuvants that promote the efficacy of R21 malaria vaccine candidate in a mouse model Soren Reinke, Joannah Ferguson, Patrice Dubois, Anita Milicic, United Kingdom

Workshop – TRACK 2 WS.T2.04 - Immune Response Regulation in Diseases 12:00 – 13:15 | HALL 1 Chairs: Danka GRCEVIC, Croatia & Christina TSIGALOU, Greece Anti-MDA5 autoantibodies in myositis patients specifically target the Helicase domains of the MDA5 protein Eveline Van Gompel, Cátia Fernandes Cerqueira, Horuluoglu Begüm, Angeles Galindo Feria, Karine Chemin, Edvard Wigren, Susanne Gräslund, Ellen De Langhe, Olivier Benveniste, Ingrid E Lundberg, Sweden Expression of neolacto-series glycosphingolipids by tumors impairs the function of low-affinity immune receptor-ligand pairs Tamara Verkerk, Antonius A. De Waard, Sophie Bliss, Sofie J. I. Koomen, Frank Buitenwerf, Tao Zhang, Carolin Gerke, Anne Halenius, Hannes Stockinger, Manfred Wuhrer, Ellen Van Der Schoot, Robbert M. Spaapen, Netherlands Small extracellular vesicles obtained from Nrp1+ T regulatory cells favor skin graft tolerance Mauricio Campos Mora, Carolina Rojas, Mónica Kurte, Felipe Gálvez Jirón, Ignacio Cárcamo, Natalia Villalón, Thilo Kaehne, Úrsula Wyneken, Karina Pino Lagos, Chile PRINS long non-coding RNA regulates IL-23 expression of keratinocytes Evelyn Kelemen, Judit Danis, Anikó Göblös, Éva Ádám, Stella Márta Sági, Zsuzsanna Bata Csörgő, Lajos Kemény, Márta Széll , Hungary Activation mechanism and secretome characterization of NLRP3 mutants associated to cryopyrin periodic syndromes Cristina Molina López, Diego Angosto Bazarra, Ana Tapia Abellán, Pablo Pelegrín, Spain Discovery of citrullination of MMP-9 in rheumatoid arthritis synovial fluid Karen Yu, Bernard Grillet, Rik Janssens, Rafaela Vaz Sousa Pereira, Estefania Ugarte Berzal, Lise Boon, Erik Martens, Pierre Fiten, Ilse Van Aelst, René Conings, Nele Berghmans, Jennifer Vandooren, Patrick Verschueren, Jo Van Damme, Paul Proost, Ghislain Opdenakker, Belgium The inflammatory nature of serum amyloid A (SAA): fact or fallacy? Sara Abouelasrar Salama, Mirre De Bondt, Mieke De Buck, Nele Berghmans, Vivian Louise Soares Oliveira, Mieke Gouwy, Sergio Oliveira, Flavio Amaral, Paul Proost, Jo Van Damme, Sofie Struyf, Belgium

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Workshop - TRACK 3 WS.T3.11 - Microbiota and Mucosa 12:00 – 13:15 | HALL 2 Chairs: Janneke SAMSOM, The Netherlands & Martin SCHWARZER, Czech Republic Dysbiosis in gut mucosa in relation to CD4 counts at cART onset and CD4 recovery Israel Olivas Martinez, Isaac Rosado Sanchez, Sergio Sobrino, Juan Antonio Cordero Varela, Miguel Genebat, Ines Herrero Fernandez, Vanesa Garrido Rodriguez, Angel Bulnes Ramos, Maria Del Mar Pozo Balado, Manuel Leal Noval, Yolanda Maria Pacheco Lopez, Spain Using multiparameter flow cytometry to understand microbiota-host crosstalk in chronic inflammatory diseases Lisa Budzinski, Toni Sempert, René Riedel, René Maier, James Cameron, Katrin Lehman, Mir Farzin Mashreghi, Ute Hoffmann, Hyun Dong Chang, Germany Fibre-associated Lachnospiraceae reduce colon tumorigenesis by modulation of the tumour-immune microenvironment Ana Santos Almeida, Tam T T Tran, Tarini S Ghosh, Celine Ribiere, Cathriona Foley, Lisa A Azevedo, Paola Pellanda, Werner Frei, Cara M Hueston, Raju Kumar, Burkhardt Flemer, Ines Sequeira, Micheal O’riordain, Fergus Shanahan, Paul W O’toole, Ireland High-protein diet and TLR9 knock out effect on the immune responses in the development of colorectal cancer Marketa Vavreckova, Alena Fajstova, Stepan Coufal, Natalie Galanova, Zuzana Stehlikova, Zuzana Jackova, Miloslav Kverka, Klara Kostovcikova, Czech Republic Potential pathogenic role for respiratory symbionts in the development of self-reactive Th17 cells Jenny Mary Mannion, Rachel Mary Mcloughlin, Stephen J Lalor, Ireland Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease Diana Elena Matei, Madhvi Menon, Dagmar Alber, Andrew Smith, Bahman Nedjat Shokouhi, Alessio Fasano, Laura Magill, Amanda Duhlin, Samuel Bitoun, Aude Gleizes, Salima Hacein Bey Abina, Jessica Manson, Elizabeth Rosser, The Abirisk Consortium, Nigel Klein, Paul Blair, Claudia Mauri, United Kingdom Clarithromycin impairs tissue-resident memory and Th17 responses to macrolide-resistant Streptococcus pneumoniae infections Marc Lindenberg, Luis Almeida, Ayesha Dhillon Labrooy, Ekkehard Siegel, Birgitta Henriques Normark, Tim Sparwasser, Germany

S3.4 – Cell Signaling 12:00 – 13:15 | HALL 3 Chairs: Sandra BEER-HAMMER, Germany & Alexandra TSIROGIANNI, Greece The Role of SLy Proteins in Immune Responses Sandra BEER-HAMMER, Germany Immunoregulatory Signal Networks and Tumor Immune Evasion Mechanisms Kjetil TASKEN, Norway The Humoral Immune Response against SARS-CoV2 Michael RETH, Germany

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S4.5 – EFIS – IL: TCC_EUROPE: T Cells in High Dimension 12:00 – 13:15 | HALL 4 from Individuality to Population Dynamics Chairs: Wilfried ELLMEIER, Austria & Lucy WALKER, United Kingdom Big Data Approach for Individualised Infection Medicine: Translating Genetic Variation into Immune Functions Yang LI, United Kingdom How Ageing Impacts the Immune Response to Vaccination Michelle LINTERMAN, United Kingdom Dissection of the Molecular Mechanisms Controlling Human T Cell Development Tom TAGHON, Belgium

Workshop - TRACK 4 WS.T4.03 - Cancer Immunotherapy - Innate Immune Responses 12:00 – 13:15 | HALL 5 Chairs: Goran MARJANOVIC, Serbia & Silke APPEL, Norway Transduction of NK cells with TYPOBP gene increases their functional activity and the NKp44 receptor expression level Maria A Streltsova, Rodion A Velichinskii, Sofya A Kust, Elena I Kovalenko, Russia Intravesical bacterial immunotherapy for bladder cancer can elicit tumor-specific immunity and relies on the capacity of the bacteria to infect and persist in the bladder Eduardo Moreo, Santiago Uranga, Carlos Martín, Nacho Aguiló, Spain Intratumoral Co-injection of the Poly I:C-derivative BO-112 and a STING Agonist Synergize to Achieve Local and Distant Anti-tumor Efficacy Maite Alvarez, Carmen Molina, Carlos E De Andrea, Myriam Fernandez Sendin, Maria Villalba, Maria Carmen Ochoa, Alvaro Teijeira, Javier Glez Vaz, Fernando Aranda, Miguel F Sanmamed, Maria E Rodriguez Ruiz, Pedro Berraondo, Marisol Quintero, Ignacio Melero, Spain NK cells release subsets of extracellular vesicles with distinct profiles and tumor-targeting abilities Yunjie Wu, Miriam A Larsen, Marit Inngjerdingen, Norway In vitro results of first in class targeted therapy in Uveal Melanoma suggest immunostimulatory capacity Sen Ma, Ruben Huis In’t Veld, Cadmus Rich, Ferry Ossendorp, Martine Jager, Netherlands Importance of antibody isotypes in antitumor immunity by monocytes using human immune tumor models Sandra Lara, Jessica C Anania, Alexander Virtanen, Viktoria Stenhammar, Sandra Kleinau, Sweden Targeting glycosaminoglycan-CCL2 interactions prevents the immunosuppressive polarization of myeloid cells and provides an anti-tumor immune response Ekaterina Pylaeva, Ilona Spyra, Elena Siakaeva, Maksim Domnich, Irem Ozel, Oliver Kanaan, Tatiana Arefieva, Maria Sidorova, Stephan Lang, Jadwiga Jablonska, Germany

Workshop - TRACK 2 WS.T2.05 - Immune Regulation by Immune Receptors 12:00 – 13:15 | HALL 6 Chairs: Dolores JARAQUEMADA, Spain & Ayça SAYI YAZGIN, Turkey Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C Julian P Vivian, Shoeib Moradi, Sanda Stankovich, Geraldine O’connor, Jamie Rossjohn, Andrew Brooks, Australia

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The structure of the marsupial γμ T cell receptor defines a third T cell lineage in vertebrates Jerome Le Nours, Kim Morrissey, Marcin Wegrecki, Praveena Thirunavukkarasu, Victoria Hansen, Komagal Sivaraman, Sam Darko, Daniel Douek, Jamie Rossjohn, Robert Miller, Australia The natural ompound Beauvericin exhibits immunostimulatory effect on dendritic cells via activating TLR4 signaling pathways Xiaoli Yang, Lisa Richter, Stefanie Scheu, Germany Signal inhibitory receptor on leukocytes-1 is an inhibitory pattern recognition receptor that recognizes bacterial and endogenous amphipathic α-helical peptides Matevž Rumpret, Helen Von Richthofen, Maarten Van Der Linden, Geertje Westerlaken, Cami Talavera Ormeño, Jos Van Strijp, Meytal Landau, Huib Ovaa, Nina Van Sorge, Linde Meyaard, Netherlands Pentraxin-3 (PTX3) circulating and synovial expression levels correlate with rheumatoid arthritis severity and tissue infiltration independently of the response to conventional treatments Marie Astrid Boutet, Alessandra Nerviani, Gloria Lliso Ribera, Roberto Leone, Marina Sironi, Rebecca Hands, Felice Rivellese, Annalisa Del Prete, Katriona Goldmann, Myles J. Lewis, Alberto Mantovani, Barbara Bottazzi, Costantino Pitzalis, France Cells deficient in membrane complement regulators as biosensors of abnormal complement deposition Rebeca F Megino, Laura R Sancho, Marta Subias, Anaïs Jimenez-Reinoso, Santiago Rodriguez de Cordoba, Pilar Sanchez-Corral, Agustin Tortajada, José R Regueiro, Edgar Fernandez-Malave, Spain DNA-PK is required for viral DNA sensing in human cells Dayana Hristova, Marisa Oliveira, Emma Wagner, Brian J Ferguson, United Kingdom

Workshop - TRACK 3 WS.T3.10 - T Cells in Atopy, Transplantation and Tolerance 12:00 – 13:15 | HALL 7 Chairs: Alexandra SIORENTA, Greece & Peter HEERINGA, The Netherlands Tolerance induction with vitamin D3, Dexamethasone or sialic acids influences maturation status and metabolic activity in human dendritic cells Joyce Lübbers, Friederike S. Gorki, Melissa S Boejharat, Sven C.m. Bruijns, Jan Van Den Bossche, Sandra J. Van Vliet, Yvette Van Kooyk,Netherlands Single cell RNA sequencing of gluten-specific CD4+ T cells reveals a novel gene expression pattern with NK-like cytotoxicity Thiruni N Adikari, Mandeep Singh, Mee Ling Munier, Raymond Louie, Jerome Samir, Varsha Balraj, Curtis Cai, Melinda Y Hardy, Jamie Ross John, Hugh Reid, Anthony D Kelleher, Jason A Tye Din, Chris Goodnow, Fabio Luciani, Australia PD-1 expressing regulatory T cells and basophils with an activating profile in infants with moderate-to- severe Atopic Dermatitis hypersensitized to food antigens Olatz Zenarruzabeitia, Agurtzane Bilbao, Raquel Pérez Garay, Alex Irurzun, Iñigo Terrén, Ane Orrantia, Gabirel Astarloa Pando, Francisco Borrego, Spain The role of DRAK2 in graft versus host disease Marygrace Duggar, Marie Wehenkel, Maureen Mcgargill, United States CD28 Superagonist TAB08-mediated activation and expansion of human regulatory T cells might protect patients from acute Graft versus Host Disease Anton Althammer, Thomas Kerkau, Alexey Matskevich, Niklas Beyersdorf, Germany

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CD160, a CD28 alternative costimulatory molecule of alloreactive CD8 T cells unable to prevent NK cell-mediated mechanisms of rejection Maria Luisa Del Rio Gonzalez, Tuan H. Nguyen, Laurent Tesson, Jean Marie Heslan, Alfonso Gutierrez Adan, Raul Fernandez Gonzalez, Julia Gutierrez Arroyo, Leo Bühler, Jose Antonio Perez Simon, Ignacio Anegon, Jose Ignacio Rodriguez Barbosa, Spain Re-circulating tissue-resident memory T cells are poised for a systemic Th2-driven host-versus-graft reaction after human allogeneic hematopoietic stem cell transplantation Johanna Strobl, Laura Marie Gail, Lisa Kleissl, Ram Vinay Pandey, Denise Atzmüller, Thomas Krausgruber, Valerie Smejkal, Julian Huber, Christoph Bock, Philipp Wohlfarth, Werner Rabitsch, Georg Stary, Austria

Workshop - TRACK 3 WS.T3.20 - COVID 19-3 12:00 – 13:15 | HALL 8 Chairs: Halis AKALIN, Turkey & Stefania BJARNARSON, Iceland Circulatory T Follicular Helper cell (cTFH) profile during SARS-CoV-2 infection Patricia Suàrez Fernández, Daniel Arroyo Sáncez, Rocío Laguna Goya, Alberto Utrero Rico, Cecilia González Cuadrado, Marta Chivite Lacaba, Patricia Almendro Vázquez, Estela Paz Artal, Spain Multi-omics analysis of the age-related effects of SARS-CoV-2 infection in rhesus macaques Jyothi N. Purushotham, Jyothi N. Purushotham, Emily Speranza, Julia R. Port, Benjamin Schwarz, Meaghan Flagg, Brandi N. Williamson, Friederike Feldmann, Lydia Roberts, Aaron Carmody, Jonathan E. Schulz, Manmeet Singh, Lizzette éP rez-Pérez, Gail Sturdevant, Atsushi Okumura, Carl Shaia, Vincent J. Munster, Emmie de Wit, United States Parallel detection of SARS-CoV-2 epitopes in convalescent COVID-19 patients reveals immunodominance and memory CD8+ T cells Jet Van Den Dijssel, Rivka De Jongh, Ruth Hagen, Niels Verstegen, Maurice Steenhuis, Wim Van Esch, Klaas Van Gisbergen, Pleun Hombrink, Anja Ten Brinke, Carolien Van De Sandt, Netherlands SARS-CoV-2-specific T cell immunity is retained 12 months post-infection and is dependent on CD4 T cells Caoimhe H. Kiernan, Melisa D. Castro Eiro, Rik Ruijten, Marjan Van Meurs, Inge Brouwers Haspels, Merel Wilmsen, Tessa Alofs, Tamara Van Wees, Yvonne M. Mueller, Peter D. Katsikis, Netherlands Differences in the SARS-COV2 IgA and IgG responses to S1, S2, RBD and N regions following a single dose of AZD1222 compared to natural infection Deshni Jayathilaka, Chandima Jeewandara, Tibutius Thanesh Pramanayagam Jayadas, Laksiri Gomes, Dinuka Guruge, Sepali Abayratne, Saubhagya Danasekara, Ruwan Wijayamuni, Graham S Ogg, Gathsaurie Neelika Malavige, Sri Lanka Deep immune phenotyping of SARS-CoV-2 specific B cell profiles after primary infection Lisan Kuijper, George Elias, Mathieu Claireaux, Mariël Duurland, Alberta Paul, Nina De Jong, Rivka De Jongh, Theo Rispens, Juan Garcia Vallejo, Niels Verstegen, Anja Ten Brinke, Marit Van Gils, Marieke Van Ham, Netherlands First-dose mRNA vaccination is sufficient to reactivate immunological memory to SARS-CoV-2 in recovered COVID-19 subjects Alessio Mazzoni, Nicoletta Di Lauria, Laura Maggi, Lorenzo Salvati, Anna Vanni, Manuela Capone, Giulia Lamacchia, Elisabetta Mantengoli, Michele Spinicci, Lorenzo Zammarchi, Seble Tekle Kiros, Arianna Rocca, Filippo Lagi, Maria Grazia Colao, Paola Parronchi, Cristina Scaletti, Lucia Turco, Francesco Liotta, Gian Maria Rossolini, Lorenzo Cosmi, Alessandro Bartoloni, Francesco Annunziato, Italy

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Workshop - TRACK 3 WS.T3.21 - Inflammation and Genetic Effects 12:00 – 13:15 | HALL 9 Chairs: Ceren CIRACI, Turkey & Aude Chatinet MAGEUS, France Hyaluronic acid in synovial fluid in inflamed joints inhibits neutrophil activation Sanne Mol, Tom Groot Kormelink, Baltus Van Der Steen, Renée Fiechter, Sander Tas, Marleen Van Der Sande, Marca Wauben, Esther De Jong, The Netherlands Prolonged neutrophil survival at necrotic sites is a fundamental feature for tissue recovery and resolution of hepatic inflammation Matheus Silvério Mattos, Mateus Eustáquio Lopes, Alan Moreira Araújo, Débora Moreira Alvarenga, Brenda Naemi Nakagaki, Kassiana Mafra Bicalho, Camila Dutra Moreira Miranda, Ariane Barros Diniz, Maísa Mota Antunes, Maria Alice Freitas Lopes, Rafael Machado Rezende, Gustavo Batista Menezes, Belgium The role of siglec-9 in ANCA-associated vasculitis Catriona Walls, Kristine Nellany, Paul Brown, Cosimo De Bari, Dana Kidder, United Kingdom Reversal clinical and immunological effects of abatacept in patients with LRBA and CTLA4 deficiencies Safa Baris, Royala Babayeva, Mehmet Cihangir Catak, Dilek Baser, Sevgi Bilgic Eltan, Gamze Akgun, Alper Bulutoglu, Ibrahim Serhat Karakus, Sefika Ilknur Kokcu Karadag, Gonca Hancioglu, Selime Oze, Ayse Senay Sasihuseyinoglu, Esra Ozek Yucel, Cigdem Aydogmus, Alisan Yildiran, Nesrin Gulez, Ferah Genel, Ayca Kiykim, Elif Karakoc Aydiner, Ahmet Ozen, Turkey TTC7A/PI4KIIIα pathway controls leukocytes’ migration Tania Gajardo, Marie Lô, Mathilde Bernard, Claire Leveau, Marie Therese El Daher, Despina Moshous, Bénédicte Neven, Alain Fischer, Gaël Ménasché, Geneviève De Saint Basile, Pablo Vargas, Fernando E. Sepulveda, France Dissecting the cellular defects that lead to activated PI3K δ Syndrome (APDS) Anthony Lau, Julia Bier, Robert Brink, Stuart Tangye, Elissa Deenick, Australia Src-family kinases in immune complex-mediated glomerulonephritis Lukács Sándor Lesinszki, Michael Robson, Attila Mócsai, Hungary

Workshop - TRACK 1 WS. Molecular and Cellular Mechanisms 12:00 – 13:15 | HALL 10 Chairs: Tolga SUTLU, Turkey & Jacques ZIMMER, Luxembourg Systems analysis reveals the unique immune system organization in the long-lived rodent Spalax Maria Metsger, Mark Izraelson, Alexey Davydov, Irina Shagina, Maria Dronina, Anna Obraztsova, Dmitry Miskevich, Ilgar Mamedov, Lilia Volchkova, Tatiana Nakonechnaya, Mikhail Shugay, Dmitry Bolotin, Dmitriy Staroverov, Georgy Sharonov, Ekaterina Kondratyuk, Elena Zagaynova, Sergey Lukyanov, Imad Shams, Olga Britanova, Dmitry Chudakov, Czech Republic Identification of a CD106+ pericyte stem cell leading to Ly6G+ cell accumulation responsible for resistance to immunotherapy in pancreatic cancer Zhichong Wu, Sophie Bachy, Xinyi Zhang, Pia Gamradt, Hernandez Vargas Hector, Ivan Mikaelian, Laurie Tonon, Roxanne Pommier, Yajie Zhao, Philippe Bertolino, Ana Hennino, France Heterotypic signaling between tumor cells and lipid-loaded macrophages drives tumor progression and resistance to therapy in cancer Michela Masetti, Roberta Carriero, Federica Portale, Giulia Marelli, Nicolò Morina, Marta Pandini, Marta Iovino, Andrea Ponzetta, Elena Magrini, Piergiuseppe Colombo, Haan Jmm Den Joke, Clelia Peano, Javier Cibella, Paolo Kunderfranco, Massimo Lazzeri, Rodolfo Hurle, Paolo Casale, Jolanda Brummelmann, Enrico Lugli, Subhankar Mukhopadhyay, Ronald Depinho, Siamon Gordon, Diletta Di Mitri, Italy 6th European Congress of Immunology, September 1-4, 2021 81 Saturday, September 4, 2021

JAK2/STAT5 signaling controls T cell polarization and development of experimental autoimmune encephalomyelitis Yingying Wei, Xiaoquan Rao, Lingli Dong, Jixin Zhong, China Metabolic fuel choices control MAIT cell functions at homeostasis and after infection Thomas Riffelmacher, Shilpi Chandra, Mallory Murray, Chantal Wientjens, Mitchell Kronenberg, United States Leveraging high-dimensional flow cytometry to assess human immune homeostasis at population- wide scale Thomas Liechti, Margaret Beddall, Sofie Van Gassen, David Novak, Thiagarajan Venkataraman, Reid Ballard, Yaser Iftikhar, Massimo Mangino, H. Benjamin Larman, Yvan Saeys, Tim Spector, Mario Roederer, United States The effect of High-Density Lipoprotein (HDL) on autophagy and mitochondrial dynamics in a monocytic cell line Simge Senay, Deniz Agirbasli, Devrim Oz Arslan, Turkey

KL.4 - Epithelial Barrier Hypothesis for The Origins of Allergic and 13:45-14:45 | HALL 1 Autoimmune Diseases Chairs : Marieke VAN HAM, The Netherlands & Miodrag LUKIC, Serbia Epithelial Barrier Hypothesis for the Origins of Allergic and Autoimmune Diseases Cezmi AKDIS, Switzerland

Closing and Awards Ceremony 15:00-16:30 | HALL 1

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Industry Sponsored Symposia, Sponsoring and Exhibition

This section contains informaion that is promotional in nature, disinct from the scientific/ educational elements of the congress.

Table of Contents Acknowledgements p. 84 Company Descriptions p. 86 Industry Sponsored Sessions p. 89 Exhibition Information p.92 Exhibitors p. 92

6th European Congress of Immunology, September 1-4, 2021 COVID-19 research Helping researchers in their work on viral threats

At Miltenyi Biotec, we stand committed to • Automated and density gradient–free helping scientists with their SARS-CoV-2 research. PBMC isolation Our optimized product selection is suited for • SARS-CoV-2–specific immune cell stimulation working with infectious materials in the most • Isolation of SARS-CoV-2–reactive immune cells efficient and safe way. • Phenotypical and functional analysis of SARS-CoV-2–specific immune cells

 miltenyibiotec.com/COVID-19

Miltenyi Biotec B.V. & Co. KG | Friedrich-Ebert-Straße 68 | 51429 Bergisch Gladbach | Germany | Phone +49 2204 8306-0 Fax +49 2204 85197 | [email protected] | www.miltenyibiotec.com Miltenyi Biotec provides products and services worldwide. Visit www.miltenyibiotec.com/local to find your nearest Miltenyi Biotec contact.

Unless otherwise specifically indicated, Miltenyi Biotec products and services are for research use only and not for therapeutic or diagnostic use. The Miltenyi Biotec logo is a registered trademark or trademark of Miltenyi Biotec and/or its affiliates in various countries worldwide. Copyright © 2021 Miltenyi Biotec and/or its affiliates. All rights reserved. 84

Acknowledgements

ECI Organizing Committee wishes to thank the following sponsors for their support of ECI 2021:

Gold Sponsor

Silver Sponsors

Bronze Sponsors

Other Sponsors

6th European Congress of Immunology, September 1-4, 2021 BD Biosciences at ECI 2021 Don’t miss our two LIVE sessions during Virtual ECI 2021 and watch the future of immunology taking shape in our discussion lounge!

Wednesday, September 1, 15.30 to 16.00 (CEST) Bifidobacteria-mediated immune system imprinting early in life Prof. Petter Brodin, Professor in Paediatric Immunology and Director of the National Mass cytometry Facility, Karolinska Insitute, Sweden.

Friday, September 3, 13.15 to 14.15 (CEST) Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states Dr. rer. nat. Simon Haas of the Max Delbruck Centre for Molecular Medicine, Berlin, Germany.

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BD and the BD Logo are trademarks of Becton, Dickinson and Company. All other trademarks are the property of their respective owners © 2021 BD and its subsidiaries. All rights reserved. BD Horizon Brilliant™ Ultraviolet dyes are for Research Use Only. Not for use in diagnostic or therapeutic procedures. 86

Company Descriptions

BD BD is one of the largest global medical technology companies in the world and is advancing the world of health by improving medical discovery, diagnostics and the delivery of care. The company develops innovative technology, services and solutions that help advance both clinical therapy for patients and clinical process for health care providers. BD and its 65,000 employees have a passion and commitment to help improve patient outcomes, improve the safety and efficiency of clinicians’ care delivery process, enable laboratory scientists to better diagnose disease and advance researchers’ capabilities to develop the next generation of diagnostics and therapeutics. BD has a presence in virtually every country and partners with organizations around the world to address some of the most challenging global health issues. BD helps customers enhance outcomes, lower costs, increase efficiencies, improve safety and expand access to health care.bd.com

Miltenyi Biotec Miltenyi Biotec is a global provider of products and services that advance biomedical research and cellular therapy. Our innovative tools support research at every level, from basic research to translational research to clinical application. Used by scientists and clinicians around the world, our technologies cover techniques of sample preparation, cell isolation, cell sorting, flow cytometry, and cell culture. Our 30 years of expertise spans research areas including immunology, stem cell biology, neuroscience, and cancer. Today, Miltenyi Biotec has about 3,000 employees in 28 countries – all dedicated to helping researchers and clinicians make a greater impact on science and health.

Thermo Fisher Scientific Thermo Fisher Scientific supplies innovative solutions for the world’s research and biotechnology industries. With applications that span the frontiers of life science and biomedical research – from cell analysis through drug discovery and large scale manufacturing – we provide a broad range of products and services including flow cytometers and cell sorters, high-quality antibody conjugates, cell viability reagents , compensation and counting beads

10x Genomics 10x Genomics was founded on the vision that this century will bring advances in biomedicine and transform the way we understand and treat disease. We build products to interrogate biological systems at a resolution and scale that matches the complexity of biology. Our rapidly expanding suite of products, which includes instruments, consumables, and software, have enabled our customers to make innovative and fundamental discoveries across multiple research areas, including cancer, immunology, and neuroscience.

Cytek Biosences Cytek Biosciences is committed to providing powerful solutions that enable scientists to rapidly and efficiently obtain deep biological insights through high quality, high parametric datasets. We are on a mission to advance cancer and cell biology research using a powerful cell analysis technique called full spectrum flow cytometry. We are satisfying long unmet needs in fields of

6th European Congress of Immunology, September 1-4, 2021 87

research such as cancer biology, immunology and genomics – and helping to advance our collective understanding and diagnosis of cancer. Our products are used at many of the world’s most renown pharmaceutical companies, CRO firms, and academic research institutions.

Beckman Coulter Beckman Coulter Life Sciences is dedicated to developing and providing advanced technologies and equipment for research and discovery to explore new treatment methods. Our products include Particle Counting and Characterization, Centrifugation, Flow Cytometry, Liquid Handling and Genomic solutions which are implemented in all major areas of Life Sciences such as biology, biochemistry, biophysics, nanotechnology and molecular biology to simplify and automate existing processes in the lab. Our vision: Advancing science through discovery – Our mission: Delivering innovative and trusted scientific solutions across the globe. For more information please visit www.beckman.com.

BioLegend BioLegend is a global trusted partner of premier research institutions, universities, industry associations, and biotech and pharmaceutical companies. Our cutting-edge, high-quality reagents and tools are developed by a team of expert scientists, giving researchers the confidence of delivering reliable and reproducible results in immunology, oncology, neuroscience, stem cells, and multiomics. From research to cure, BioLegend pushes the boundaries of innovation to enable legendary discoveries.

GSK A science-led global healthcare company with a special purpose to improve the quality of human life by helping people do more, feel better, live longer. Every day, we help improve the health of millions of people around the world by discovering, developing and manifacturing innovative medicines, vaccines and consumer healthcare products.

6th European Congress of Immunology, September 1-4, 2021

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Industry Sponsored Sessions

Wednesday, September 1, 2021 Industry Sponsored Interactive Session Discussion Lounge 15:30 – 16:00| ROOM 1 Bifidobacteria-Mediated Immune System Imprinting Early in Life Petter BRODIN, Sweden

Industry Sponsored Symposium: Beckman Coulter 17:45 – 18:45| HALL 1

Towards Simplified and Standardized Monitoring of Human Innate Lymphoid Cells using DURAClone Tubes Maciej CABANSKI, Germany

Industry Sponsored Symposium: 10x Genomics and BioLegend 17:45 – 18:45| HALL 2 Single-Cell Multi-Omics Analysis of the Immune Response in COVID-19 Emily STEPHENSON, United Kingdom Single-Cell Multi-Omics Profiling of Breast Tumors Treated with Checkpoint Immunotherapy Diether LAMBRECHTS, Belgium

Thursday, September 2, 2021

Industry Sponsored Symposium: Thermo Fisher Scientific 13:30 -14:30 | HALL 1 Immunological Advances in the Battle Against SARS Cov-2 and Cancer Andrea COSSARIZZA, Italy Antonio RIVA, United Kingdom

Progress in Technoology Session: Luminex B.V 13:30 – 14:00 | HALL 2 xMAP INTELLIFLEX – A Rich History of Enabling Groundbreaking research Ruud JORNA, The Netherlands

Progress in Technology Session: Takeda 13:30 – 14:00 | HALL 3 Moving Towards Individualising Care with Immunoglobulin Replacement Therapies in Patients with Primary Immunodeficiency Chair: Elif AYDINER KARAKOÇ, Turkey Sebnem KILIC, Turkey

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Industry Sponsored Symposium: Cytek Biosciences 13:30 – 14:30 | HALL 5 Full Spectrum Profiling (FSP™) Let You See It, Now Aurora CS Will Let You Sort It! Gil REININ Maria JAIMES Industry Sponsored Interactive Session Discussion Lounge 14:30 – 15:30| ROOM 2 Single cell transcriptional profiling is a powerful tool for studying the adaptive immune system, enabling the researcher to study 1000-100,00s of cells simultaneously resolving the gene expression on a single cell basis and studying the T and B cell receptors on immune cells. Please join us for a demonstration of the data analysis for this solution and a Q&A session. Speakers: Aydan SARAC DERDIYOK Application Scientist, 10x Genomics

Stephen HAGUE Science and Technology Advisor, 10x Genomics

Friday, September 3, 2021

Industry Sponsored Symposium: Miltenyi Biotec 13:15 – 14:15 | HALL 1 Latest Findings and Innovative Solutions in SARS-CoV-2 Research Marcello STEIN, Germany Ryan G. NATTRASS, Germany Laura MAGGI, Italy

Industry Sponsored Symposium: BD 13:15 – 14:15 | HALL 2 Novel Multimodal Single-Cell and Spatially-Resolved Technologies to Study The Complex Etiology of Hematological Cancers and Their Interaction with The Immune System Simon HAAS, Sweden

Progress in Technoology Session: Thermofisher 13:15 – 13:45 | HALL 3 Attune CytPix Flow Cytometer in Action Cora CHADICK, The Netherlands

Progress in Technoology Session: Fluidigm 13:15 – 13:45 | HALL 4 High-Throughput and Automated High-Dimensional Immune Phenotyping Roberto SPADA, Spain

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Industry Sponsored Interactive Session Career Development Lounge 18:45-19:45 | ROOM 1 Speakers Jekaterina ALEKSEJEVA Regional Marketing Manager, 10x Genomics

David MCGRANE EMEA Talent Acquisition, 10x Genomics

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Exhibition Information

The exhibition is an important component of the ECI congress, providing paricipants with an ideal plaform to network with industry partners. This year, at ECI 2021 there will be a virtual exhibition hall with virtual booths. Many booths have interactive features for participants to engage with industry partners. Exhibition area will be accessible anytime during the congress dates and also after the congress until December 31, 2021.

Exhibitors The following companies are exhibiting at the virtual ECI 2021 (as per August 20, 2021) 10x Genomics Inc. Agilent Technologies Beckman Coulter Beckton Dickinson BioLegend Cytek Biosciences Fluidigm KDBIO Luminex B.V. Miltenyi Biotec Quanterix Stemcell Technologies Takeda

Immunological Village American Association of Immunologists (AAI) Austrian Society for Allergology and Immunology (ÖGAI) British Society for Immunology (BSI) Dutch Society for Immunology (NVVI) European Federation of Immunological Societies (EFIS) Georgian Association of Allergology and Clinical Immunology (GAACI) German Society for Immunology (DGFI) Immunological Society of Serbia (ISoS) International Union of Immunological Societies (IUIS) Irish Society for Immunology (ISI) Italian Society of Immunology (SIICA) Turkish Society of Immunology (TSI) yEFIS Task Force

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Virtual Social Program Science Communication Workshops & Performance ECI 2021 is offering a unique event as part of the virtual social program. 2-day interactive science communication workshop ends with a live performance by the award winning science communicator, Dr. Dmitry Kopelyanskiy and a competition on Friday evening.

Scicom-W: Science Communication Workshops Wednesday, September 1, 2021 / 17:15 CET Thursday, September 2, 2021 / 18:30 CET Scicom-W is an intensive two-hour long session introducing novel methods to communicate complicated scientific topics to a wide range of audience regardless of their educational background. Three main aspects of science communication will be at the focus of the workshop: Time management, Structure of storytelling and Rules of capturing attention. The participants will be provided with the state-of-the-art scientific literature addressing these challenges. More importantly each participant will be able to practice the method of choice and discuss the outcome with the trainer and the other participants during the workshop in order to find the most fitting approach to their personality and aims.

Live Performance and Science Communication Competition Friday, September 3 / 20:00 CET Scicom-5mins is carried out with one moderator, five volunteer speakers, and active participation of the audience. In addition, a well-known science communication celebrity will also deliver a talk for kick-off. Each speaker is introduced by the moderator and has 5 minutes to give a talk without using any PowerPoint tools. The talks should give “necessary” amount of information to the audience and provoke their curiosity. Afterwards the audience asks questions to the speakers. The questions are evaluated by the speakers according to the criteria given below. The most sceptic question (Sherlock award) The most obvious question (Captain Obvious award) The most show-off question (Sheldon Cooper award) Ig Nobel question (Sponsor-Winner award for the question that make people laugh, and then make them think)

Science-Com Science-Com is an online event combining an interactive science communication workshop (Scicom-W) and live performance (Scicom-5mins) prepared by the “ScicomHD” team based in Heidelberg, Germany (www.scicomhd.com)

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scicomHD Trainer for ECI 2021: Dr. Veli Vural Uslu (www.scicomHD.com) Dr. Uslu graduated from Bilkent University, Ankara, Turkey as the top-ranking student. He finished his PhD on developmental genetics at EMBL-Heidelberg with the prestigious Darwin- Trust Prize. He took a postdoc position at Uni-Heidelberg in plant physiology department as a long term EMBO-Fellow. Currently, he is a Project leader at AgroScience GmbH in Germany and lectures at Uni-Heidelberg. He has first author publications in reputable journals like Nature and Nature Genetics. He is the founder and the director of Heidelberg Science Theater since 2015. He founded theater-based science communication training initiative “ScicomHD” in 2018 and since then he has been offering workshops and events for graduate students and researchers all around Europe, particularly in Germany. In 2018, Dr. Uslu became the national winner of the biggest science communication competition worldwide -FameLab- in Germany, and as the representative of Germany he came runner up in the international Famelab 2018 competition.

Wine Lounge: Discover Turkish Wines Only 7000 years young Thursday, September 2, 2021 / 19:30 CET Uncorking Turkish Wines (Virtually) Where it all began: We are pleased to invite you to grab your favorite wine and join us for a tasteful conversation about Turkish Wines. Our speaker, Sibel Kutman Oral, will gladly answer questions from the audience. Sibel Kutman Oral was born in 1975 in Istanbul. After completing her high school education at Robert College, she studied Modern Dance and Business Marketing at Wesleyan University in the USA. She then completed Wine Post Production and Degustation education at New York University. Upon her return to Turkey, she worked as Marketing Director in Doluca Winery between 1998 and 2008, and since2008 has been serving as a board member at Doluca Winery.

6th European Congress of Immunology, September 1-4, 2021